Phenethyl Isothiocyanate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Phenethyl Isothiocyanate
Accession Number
DB12695
Type
Small Molecule
Groups
Investigational
Description

Phenethyl Isothiocyanate has been used in trials studying the prevention and treatment of Leukemia, Lung Cancer, Tobacco Use Disorder, and Lymphoproliferative Disorders.

Structure
Thumb
Synonyms
Not Available
External IDs
FEMA NO. 4014 / NSC-87868
Categories
UNII
6U7TFK75KV
CAS number
2257-09-2
Weight
Average: 163.239
Monoisotopic: 163.045569983
Chemical Formula
C9H9NS
InChI Key
IZJDOKYDEWTZSO-UHFFFAOYSA-N
InChI
InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2
IUPAC Name
(2-isothiocyanatoethyl)benzene
SMILES
S=C=NCCC1=CC=CC=C1

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UActin, aortic smooth muscleNot AvailableHuman
UActin, cytoplasmic 1Not AvailableHuman
UATP synthase subunit beta, mitochondrialNot AvailableHuman
UATP synthase subunit e, mitochondrialNot AvailableHuman
UATP synthase subunit g, mitochondrialNot AvailableHuman
UCytochrome b5 type BNot AvailableHuman
UDiablo homolog, mitochondrialNot AvailableHuman
UF-box only protein 41Not AvailableHuman
UHeterogeneous nuclear ribonucleoprotein FNot AvailableHuman
UHeterogeneous nuclear ribonucleoprotein KNot AvailableHuman
UHeat shock 70 kDa protein 4Not AvailableHuman
UHeat shock protein beta-1Not AvailableHuman
U10 kDa heat shock protein, mitochondrialNot AvailableHuman
UHeat shock protein 105 kDaNot AvailableHuman
UNADH-ubiquinone oxidoreductase chain 1Not AvailableHuman
UNuclear migration protein nudCNot AvailableHuman
UPappalysin-1Not AvailableHuman
UProteasome subunit alpha type-3Not AvailableHuman
U26S protease regulatory subunit 6ANot AvailableHuman
URan-specific GTPase-activating proteinNot AvailableHuman
UProtein S100-A10Not AvailableHuman
USplicing factor 3A subunit 3Not AvailableHuman
USWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1Not AvailableHuman
USuccinyl-CoA ligase [GDP-forming] subunit beta, mitochondrialNot AvailableHuman
UTumor protein D54Not AvailableHuman
UTropomyosin alpha-1 chainNot AvailableHuman
UTropomyosin alpha-3 chainNot AvailableHuman
UTropomyosin alpha-4 chainNot AvailableHuman
UTubulin alpha-1A chainNot AvailableHuman
UTubulin alpha-3C/D chainNot AvailableHuman
UTubulin alpha-4A chainNot AvailableHuman
UTubulin beta-1 chainNot AvailableHuman
UTubulin beta-2A chainNot AvailableHuman
UTubulin beta-3 chainNot AvailableHuman
UTubulin beta-4B chainNot AvailableHuman
UThioredoxinNot AvailableHuman
UUbiquitin carboxyl-terminal hydrolase isozyme L1Not AvailableHuman
UUbiquitin carboxyl-terminal hydrolase 14Not AvailableHuman
UTransitional endoplasmic reticulum ATPaseNot AvailableHuman
UVimentinNot AvailableHuman
U14-3-3 protein beta/alphaNot AvailableHuman
U14-3-3 protein epsilonNot AvailableHuman
U14-3-3 protein etaNot AvailableHuman
U14-3-3 protein thetaNot AvailableHuman
U14-3-3 protein zeta/deltaNot AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Phenethyl Isothiocyanate.Approved
AcetyldigoxinAcetyldigoxin may decrease the cardiotoxic activities of Phenethyl Isothiocyanate.Experimental
BevacizumabBevacizumab may increase the cardiotoxic activities of Phenethyl Isothiocyanate.Approved, Investigational
CabazitaxelThe risk or severity of adverse effects can be increased when Cabazitaxel is combined with Phenethyl Isothiocyanate.Approved
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Phenethyl Isothiocyanate.Approved, Investigational
CymarinCymarin may decrease the cardiotoxic activities of Phenethyl Isothiocyanate.Experimental
DeslanosideDeslanoside may decrease the cardiotoxic activities of Phenethyl Isothiocyanate.Approved
DigitoxinDigitoxin may decrease the cardiotoxic activities of Phenethyl Isothiocyanate.Approved, Investigational
DigoxinDigoxin may decrease the cardiotoxic activities of Phenethyl Isothiocyanate.Approved
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Phenethyl Isothiocyanate.Approved, Investigational
GitoformateGitoformate may decrease the cardiotoxic activities of Phenethyl Isothiocyanate.Experimental
Lanatoside CLanatoside C may decrease the cardiotoxic activities of Phenethyl Isothiocyanate.Experimental
MetildigoxinMetildigoxin may decrease the cardiotoxic activities of Phenethyl Isothiocyanate.Experimental
OleandrinOleandrin may decrease the cardiotoxic activities of Phenethyl Isothiocyanate.Experimental, Investigational
OuabainOuabain may decrease the cardiotoxic activities of Phenethyl Isothiocyanate.Approved
PaclitaxelThe risk or severity of adverse effects can be increased when Paclitaxel is combined with Phenethyl Isothiocyanate.Approved, Vet Approved
PeruvosidePeruvoside may decrease the cardiotoxic activities of Phenethyl Isothiocyanate.Experimental
ProscillaridinProscillaridin may decrease the cardiotoxic activities of Phenethyl Isothiocyanate.Experimental
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Phenethyl Isothiocyanate.Approved, Investigational
Food Interactions
Not Available

References

General References
Not Available
External Links
Human Metabolome Database
HMDB38445
PubChem Compound
16741
PubChem Substance
347828896
ChemSpider
15870
BindingDB
50240850
ChEBI
351346
ChEMBL
CHEMBL151649

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedPreventionLung Cancers1
1WithdrawnTreatmentLeukemias / Lymphoproliferative Disorders1
2Unknown StatusPreventionLung Cancers / Tobacco Use Disorders1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0277 mg/mLALOGPS
logP3.41ALOGPS
logP3.08ChemAxon
logS-3.8ALOGPS
pKa (Strongest Basic)-3.1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area12.36 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity50.7 m3·mol-1ChemAxon
Polarizability18.1 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-0lxx-9600000000-1487c40cb717ac50d540
GC-MS Spectrum - EI-BGC-MSsplash10-0006-9300000000-dce10ef46bd36fa88995
Mass Spectrum (Electron Ionization)MSsplash10-0006-9400000000-89e2793dff2133a5d196
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Not Available
Direct Parent
Benzene and substituted derivatives
Alternative Parents
Isothiocyanates / Propargyl-type 1,3-dipolar organic compounds / Organopnictogen compounds / Organonitrogen compounds / Hydrocarbon derivatives
Substituents
Monocyclic benzene moiety / Isothiocyanate / Organic 1,3-dipolar compound / Propargyl-type 1,3-dipolar organic compound / Organic nitrogen compound / Organopnictogen compound / Hydrocarbon derivative / Organosulfur compound / Organonitrogen compound / Aromatic homomonocyclic compound
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
isothiocyanate (CHEBI:351346)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Protein kinase binding
Specific Function
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Gene Name
ACTA2
Uniprot ID
P62736
Uniprot Name
Actin, aortic smooth muscle
Molecular Weight
42008.57 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Tat protein binding
Specific Function
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Gene Name
ACTB
Uniprot ID
P60709
Uniprot Name
Actin, cytoplasmic 1
Molecular Weight
41736.37 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Transporter activity
Specific Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport comp...
Gene Name
ATP5B
Uniprot ID
P06576
Uniprot Name
ATP synthase subunit beta, mitochondrial
Molecular Weight
56559.42 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
Specific Function
Hydrogen ion transmembrane transporter activity
Gene Name
ATP5I
Uniprot ID
P56385
Uniprot Name
ATP synthase subunit e, mitochondrial
Molecular Weight
7933.11 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
Specific Function
Hydrogen ion transmembrane transporter activity
Gene Name
ATP5L
Uniprot ID
O75964
Uniprot Name
ATP synthase subunit g, mitochondrial
Molecular Weight
11428.4 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.
Gene Name
CYB5B
Uniprot ID
O43169
Uniprot Name
Cytochrome b5 type B
Molecular Weight
16332.005 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Specific Function
Not Available
Gene Name
DIABLO
Uniprot ID
Q9NR28
Uniprot Name
Diablo homolog, mitochondrial
Molecular Weight
27130.58 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Specific Function
Ubiquitin-protein transferase activity
Gene Name
FBXO41
Uniprot ID
Q8TF61
Uniprot Name
F-box only protein 41
Molecular Weight
94495.26 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.
Specific Function
Rna binding
Gene Name
HNRNPF
Uniprot ID
P52597
Uniprot Name
Heterogeneous nuclear ribonucleoprotein F
Molecular Weight
45671.61 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
Specific Function
Cadherin binding
Gene Name
HNRNPK
Uniprot ID
P61978
Uniprot Name
Heterogeneous nuclear ribonucleoprotein K
Molecular Weight
50975.81 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Atp binding
Gene Name
HSPA4
Uniprot ID
P34932
Uniprot Name
Heat shock 70 kDa protein 4
Molecular Weight
94330.225 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Ubiquitin binding
Specific Function
Involved in stress resistance and actin organization.
Gene Name
HSPB1
Uniprot ID
P04792
Uniprot Name
Heat shock protein beta-1
Molecular Weight
22782.3 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:7912672, PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable).
Specific Function
Atp binding
Gene Name
HSPE1
Uniprot ID
P61604
Uniprot Name
10 kDa heat shock protein, mitochondrial
Molecular Weight
10931.645 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).
Specific Function
Adenyl-nucleotide exchange factor activity
Gene Name
HSPH1
Uniprot ID
Q92598
Uniprot Name
Heat shock protein 105 kDa
Molecular Weight
96864.305 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Nadh dehydrogenase (ubiquinone) activity
Specific Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the tra...
Gene Name
MT-ND1
Uniprot ID
P03886
Uniprot Name
NADH-ubiquinone oxidoreductase chain 1
Molecular Weight
35660.055 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
Specific Function
Cadherin binding
Gene Name
NUDC
Uniprot ID
Q9Y266
Uniprot Name
Nuclear migration protein nudC
Molecular Weight
38242.7 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Specific Function
Metalloendopeptidase activity
Gene Name
PAPPA
Uniprot ID
Q13219
Uniprot Name
Pappalysin-1
Molecular Weight
180971.11 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Threonine-type endopeptidase activity
Specific Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly ...
Gene Name
PSMA3
Uniprot ID
P25788
Uniprot Name
Proteasome subunit alpha type-3
Molecular Weight
28432.97 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Specific Function
Atp binding
Gene Name
PSMC3
Uniprot ID
P17980
Uniprot Name
26S protease regulatory subunit 6A
Molecular Weight
49203.11 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.
Specific Function
Cadherin binding
Gene Name
RANBP1
Uniprot ID
P43487
Uniprot Name
Ran-specific GTPase-activating protein
Molecular Weight
23309.92 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
Specific Function
Calcium ion binding
Gene Name
S100A10
Uniprot ID
P60903
Uniprot Name
Protein S100-A10
Molecular Weight
11203.06 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
Specific Function
Rna binding
Gene Name
SF3A3
Uniprot ID
Q12874
Uniprot Name
Splicing factor 3A subunit 3
Molecular Weight
58848.42 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.
Specific Function
Chromatin binding
Gene Name
SMARCE1
Uniprot ID
Q969G3
Uniprot Name
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Molecular Weight
46649.09 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Succinate-coa ligase (gdp-forming) activity
Specific Function
Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA.
Gene Name
SUCLG2
Uniprot ID
Q96I99
Uniprot Name
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
Molecular Weight
46510.215 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Protein heterodimerization activity
Gene Name
TPD52L2
Uniprot ID
O43399
Uniprot Name
Tumor protein D54
Molecular Weight
22237.535 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Specific Function
Actin binding
Gene Name
TPM1
Uniprot ID
P09493
Uniprot Name
Tropomyosin alpha-1 chain
Molecular Weight
32708.175 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Specific Function
Actin filament binding
Gene Name
TPM3
Uniprot ID
P06753
Uniprot Name
Tropomyosin alpha-3 chain
Molecular Weight
32949.61 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.
Specific Function
Actin filament binding
Gene Name
TPM4
Uniprot ID
P67936
Uniprot Name
Tropomyosin alpha-4 chain
Molecular Weight
28521.535 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Specific Function
Gtp binding
Gene Name
TUBA1A
Uniprot ID
Q71U36
Uniprot Name
Tubulin alpha-1A chain
Molecular Weight
50135.25 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Structural constituent of cytoskeleton
Specific Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Gene Name
TUBA3C
Uniprot ID
Q13748
Uniprot Name
Tubulin alpha-3C/D chain
Molecular Weight
49959.145 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Structural constituent of cytoskeleton
Specific Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Gene Name
TUBA4A
Uniprot ID
P68366
Uniprot Name
Tubulin alpha-4A chain
Molecular Weight
49923.995 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Structural constituent of cytoskeleton
Specific Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Gene Name
TUBB1
Uniprot ID
Q9H4B7
Uniprot Name
Tubulin beta-1 chain
Molecular Weight
50326.56 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Structural constituent of cytoskeleton
Specific Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Gene Name
TUBB2A
Uniprot ID
Q13885
Uniprot Name
Tubulin beta-2A chain
Molecular Weight
49906.67 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Structural constituent of cytoskeleton
Specific Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a criti...
Gene Name
TUBB3
Uniprot ID
Q13509
Uniprot Name
Tubulin beta-3 chain
Molecular Weight
50432.355 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Unfolded protein binding
Specific Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Gene Name
TUBB4B
Uniprot ID
P68371
Uniprot Name
Tubulin beta-4B chain
Molecular Weight
49830.72 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Protein disulfide oxidoreductase activity
Specific Function
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversib...
Gene Name
TXN
Uniprot ID
P10599
Uniprot Name
Thioredoxin
Molecular Weight
11737.42 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Ubiquitin-specific protease activity
Specific Function
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at t...
Gene Name
UCHL1
Uniprot ID
P09936
Uniprot Name
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Molecular Weight
24824.17 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
Specific Function
Cysteine-type endopeptidase activity
Gene Name
USP14
Uniprot ID
P54578
Uniprot Name
Ubiquitin carboxyl-terminal hydrolase 14
Molecular Weight
56068.665 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Not Available
Gene Name
VCP
Uniprot ID
P55072
Uniprot Name
Transitional endoplasmic reticulum ATPase
Molecular Weight
89320.885 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Structural constituent of eye lens
Specific Function
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, eit...
Gene Name
VIM
Uniprot ID
P08670
Uniprot Name
Vimentin
Molecular Weight
53651.165 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
Specific Function
Cadherin binding
Gene Name
YWHAB
Uniprot ID
P31946
Uniprot Name
14-3-3 protein beta/alpha
Molecular Weight
28082.165 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Ubiquitin protein ligase binding
Specific Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine o...
Gene Name
YWHAE
Uniprot ID
P62258
Uniprot Name
14-3-3 protein epsilon
Molecular Weight
29173.58 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Specific Function
Actin binding
Gene Name
YWHAH
Uniprot ID
Q04917
Uniprot Name
14-3-3 protein eta
Molecular Weight
28218.445 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Specific Function
14-3-3 protein binding
Gene Name
YWHAQ
Uniprot ID
P27348
Uniprot Name
14-3-3 protein theta
Molecular Weight
27763.93 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Ubiquitin protein ligase binding
Specific Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine o...
Gene Name
YWHAZ
Uniprot ID
P63104
Uniprot Name
14-3-3 protein zeta/delta
Molecular Weight
27744.84 Da
References
  1. Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL: Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26. [PubMed:21838287]

Drug created on October 20, 2016 17:39 / Updated on November 09, 2017 05:11