Ferritin light chain

Details

Name
Ferritin light chain
Synonyms
  • Ferritin L subunit
Gene Name
FTL
Organism
Humans
Amino acid sequence
>lcl|BSEQ0036948|Ferritin light chain
MSSQIRQNYSTDVEAAVNSLVNLYLQASYTYLSLGFYFDRDDVALEGVSHFFRELAEEKR
EGYERLLKMQNQRGGRALFQDIKKPAEDEWGKTPDAMKAAMALEKKLNQALLDLHALGSA
RTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHRLGGPEAGLGEYLFERLTLKHD
Number of residues
175
Molecular Weight
20019.49
Theoretical pI
5.59
GO Classification
Functions
ferric iron binding / identical protein binding / iron ion binding
Processes
cellular iron ion homeostasis / iron ion homeostasis / iron ion transport / membrane organization / post-Golgi vesicle-mediated transport / receptor-mediated endocytosis / transmembrane transport
Components
cytosol / extracellular exosome / intracellular ferritin complex / membrane
General Function
Iron ion binding
Specific Function
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0016009|Ferritin light chain (FTL)
ATGAGCTCCCAGATTCGTCAGAATTATTCCACCGACGTGGAGGCAGCCGTCAACAGCCTG
GTCAATTTGTACCTGCAGGCCTCCTACACCTACCTCTCTCTGGGCTTCTATTTCGACCGC
GATGATGTGGCTCTGGAAGGCGTGAGCCACTTCTTCCGCGAATTGGCCGAGGAGAAGCGC
GAGGGCTACGAGCGTCTCCTGAAGATGCAAAACCAGCGTGGCGGCCGCGCTCTCTTCCAG
GACATCAAGAAGCCAGCTGAAGATGAGTGGGGTAAAACCCCAGACGCCATGAAAGCTGCC
ATGGCCCTGGAGAAAAAGCTGAACCAGGCCCTTTTGGATCTTCATGCCCTGGGTTCTGCC
CGCACGGACCCCCATCTCTGTGACTTCCTGGAGACTCACTTCCTAGATGAGGAAGTGAAG
CTTATCAAGAAGATGGGTGACCACCTGACCAACCTCCACAGGCTGGGTGGCCCGGAGGCT
GGGCTGGGCGAGTATCTCTTCGAAAGGCTCACTCTCAAGCACGACTAA
Chromosome Location
19
Locus
19q13.3-q13.4
External Identifiers
ResourceLink
UniProtKB IDP02792
UniProtKB Entry NameFRIL_HUMAN
GenBank Protein ID182514
GenBank Gene IDM11147
GenAtlas IDFTL
HGNC IDHGNC:3999
General References
  1. Boyd D, Vecoli C, Belcher DM, Jain SK, Drysdale JW: Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones. J Biol Chem. 1985 Sep 25;260(21):11755-61. [PubMed:3840162]
  2. Dorner MH, Salfeld J, Will H, Leibold EA, Vass JK, Munro HN: Structure of human ferritin light subunit messenger RNA: comparison with heavy subunit message and functional implications. Proc Natl Acad Sci U S A. 1985 May;82(10):3139-43. [PubMed:3858810]
  3. Santoro C, Marone M, Ferrone M, Costanzo F, Colombo M, Minganti C, Cortese R, Silengo L: Cloning of the gene coding for human L apoferritin. Nucleic Acids Res. 1986 Apr 11;14(7):2863-76. [PubMed:3754330]
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  8. Chou CC, Gatti RA, Fuller ML, Concannon P, Wong A, Chada S, Davis RC, Salser WA: Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro. Mol Cell Biol. 1986 Feb;6(2):566-73. [PubMed:3023856]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00893Iron Dextranapproved, vet_approvedyesotherDetails
DB02285ProtoporphyrinexperimentalunknownDetails
DB06784Gallium citrate Ga 67approvedyessubstrateDetails
DB09517Sodium ferric gluconate complexapprovedyesbindingDetails
DB09147Ferric pyrophosphateexperimentalyesbinderDetails
DB13995Ferric pyrophosphate citrateapproved, investigationalyesbinderDetails
DB06215Ferumoxytolapproved, investigationalyesstorageDetails
DB13257Ferrous sulfate anhydrousapprovedyesstorageDetails