30S ribosomal protein S4

Details

Name
30S ribosomal protein S4
Synonyms
  • rps4
Gene Name
rpsD
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Amino acid sequence
>lcl|BSEQ0012931|30S ribosomal protein S4
MGRYIGPVCRLCRREGVKLYLKGERCYSPKCAMERRPYPPGQHGQKRARRPSDYAVRLRE
KQKLRRIYGISERQFRNLFEEASKKKGVTGSVFLGLLESRLDNVVYRLGFAVSRRQARQL
VRHGHITVNGRRVDLPSYRVRPGDEIAVAEKSRNLELIRQNLEAMKGRKVGPWLSLDVEG
MKGKFLRLPDREDLALPVNEQLVIEFYSR
Number of residues
209
Molecular Weight
24324.11
Theoretical pI
11.04
GO Classification
Functions
metal ion binding / rRNA binding / structural constituent of ribosome
Processes
translation
Components
small ribosomal subunit
General Function
Structural constituent of ribosome
Specific Function
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the body and platform of the 30S subunit. Binds mRNA in the 70S ribosome, positioning it for translation.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0012932|30S ribosomal protein S4 (rpsD)
ATGGGTCGTTACATTGGTCCAGTTTGCCGTCTTTGCCGCCGGGAAGGCGTGAAGCTCTAC
CTCAAGGGGGAGCGGTGCTACAGCCCCAAGTGCGCCATGGAGCGCCGCCCCTACCCCCCT
GGGCAGCACGGGCAGAAGCGGGCGCGCCGCCCCTCCGACTACGCGGTGCGGCTTAGGGAG
AAGCAGAAGCTCCGCCGGATCTACGGCATCTCCGAGCGCCAGTTCCGCAACCTGTTTGAG
GAGGCGAGCAAGAAGAAGGGCGTCACGGGCTCCGTCTTCCTGGGGCTTTTGGAGTCCCGT
CTGGACAACGTGGTCTACCGGCTGGGCTTCGCCGTAAGCCGCCGCCAGGCCCGCCAGCTG
GTGCGCCACGGGCACATCACCGTGAACGGGCGCCGGGTGGACCTCCCCTCCTACCGGGTC
CGGCCCGGGGACGAGATCGCCGTGGCCGAGAAGAGCCGCAACCTCGAGCTCATCCGCCAG
AACCTCGAGGCCATGAAGGGCCGGAAGGTGGGCCCCTGGCTCTCCCTGGACGTGGAGGGC
ATGAAGGGCAAGTTCCTCCGCCTGCCCGACCGGGAGGACCTGGCCCTGCCCGTGAACGAG
CAGCTGGTGATCGAGTTCTACTCCAGGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP80373
UniProtKB Entry NameRS4_THET8
GenBank Protein ID4519419
GenBank Gene IDAB024328
General References
  1. Wada T, Yamazaki T, Kuramitsu S, Kyogoku Y: Cloning of the RNA polymerase alpha subunit gene from Thermus thermophilus HB8 and characterization of the protein. J Biochem. 1999 Jan;125(1):143-50. [Article]
  2. Tsiboli P, Herfurth E, Choli T: Purification and characterization of the 30S ribosomal proteins from the bacterium Thermus thermophilus. Eur J Biochem. 1994 Nov 15;226(1):169-77. [Article]
  3. Suh MJ, Hamburg DM, Gregory ST, Dahlberg AE, Limbach PA: Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry. Proteomics. 2005 Dec;5(18):4818-31. [Article]
  4. Clemons WM Jr, May JL, Wimberly BT, McCutcheon JP, Capel MS, Ramakrishnan V: Structure of a bacterial 30S ribosomal subunit at 5.5 A resolution. Nature. 1999 Aug 26;400(6747):833-40. doi: 10.1038/23631. [Article]
  5. Wimberly BT, Brodersen DE, Clemons WM Jr, Morgan-Warren RJ, Carter AP, Vonrhein C, Hartsch T, Ramakrishnan V: Structure of the 30S ribosomal subunit. Nature. 2000 Sep 21;407(6802):327-39. [Article]
  6. Schluenzen F, Tocilj A, Zarivach R, Harms J, Gluehmann M, Janell D, Bashan A, Bartels H, Agmon I, Franceschi F, Yonath A: Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution. Cell. 2000 Sep 1;102(5):615-23. [Article]
  7. Brodersen DE, Clemons WM Jr, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V: The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell. 2000 Dec 22;103(7):1143-54. [Article]
  8. Carter AP, Clemons WM, Brodersen DE, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V: Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8. [Article]
  9. Yusupova GZ, Yusupov MM, Cate JH, Noller HF: The path of messenger RNA through the ribosome. Cell. 2001 Jul 27;106(2):233-41. [Article]
  10. Pioletti M, Schlunzen F, Harms J, Zarivach R, Gluhmann M, Avila H, Bashan A, Bartels H, Auerbach T, Jacobi C, Hartsch T, Yonath A, Franceschi F: Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3. EMBO J. 2001 Apr 17;20(8):1829-39. [Article]
  11. Carter AP, Clemons WM Jr, Brodersen DE, Morgan-Warren RJ, Hartsch T, Wimberly BT, Ramakrishnan V: Crystal structure of an initiation factor bound to the 30S ribosomal subunit. Science. 2001 Jan 19;291(5503):498-501. [Article]
  12. Yusupov MM, Yusupova GZ, Baucom A, Lieberman K, Earnest TN, Cate JH, Noller HF: Crystal structure of the ribosome at 5.5 A resolution. Science. 2001 May 4;292(5518):883-96. Epub 2001 Mar 29. [Article]
  13. Ogle JM, Brodersen DE, Clemons WM Jr, Tarry MJ, Carter AP, Ramakrishnan V: Recognition of cognate transfer RNA by the 30S ribosomal subunit. Science. 2001 May 4;292(5518):897-902. [Article]
  14. Brodersen DE, Clemons WM Jr, Carter AP, Wimberly BT, Ramakrishnan V: Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 S RNA. J Mol Biol. 2002 Feb 22;316(3):725-68. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB081852-METHYLTHIO-N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATEexperimentalunknownDetails