Cytochrome c

Details

Name
Cytochrome c
Synonyms
  • CYC
Gene Name
CYCS
Organism
Humans
Amino acid sequence
>lcl|BSEQ0010707|Cytochrome c
MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIW
GEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE
Number of residues
105
Molecular Weight
11748.69
Theoretical pI
10.16
GO Classification
Functions
electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity / heme binding / metal ion binding
Processes
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c / apoptotic process / ATP synthesis coupled electron transport / cellular metabolic process / cellular respiration / gene expression / intrinsic apoptotic signaling pathway / mitochondrial electron transport, cytochrome c to oxygen / mitochondrial electron transport, ubiquinol to cytochrome c / mitochondrion organization / organelle organization / programmed cell death / protein dephosphorylation / respiratory electron transport chain / response to reactive oxygen species / small molecule metabolic process / transcription initiation from RNA polymerase II promoter
Components
cytosol / mitochondrial inner membrane / mitochondrial intermembrane space / mitochondrion / nucleus / protein phosphatase type 2A complex / respiratory chain
General Function
Metal ion binding
Specific Function
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Mitochondrion intermembrane space
Gene sequence
>lcl|BSEQ0010708|Cytochrome c (CYCS)
ATGGGTGATGTTGAGAAAGGCAAGAAGATTTTTATTATGAAGTGTTCCCAGTGCCACACC
GTTGAAAAGGGAGGCAAGCACAAGACTGGGCCAAATCTCCATGGTCTCTTTGGGCGGAAG
ACAGGTCAGGCCCCTGGATACTCTTACACAGCCGCCAATAAGAACAAAGGCATCATCTGG
GGAGAGGATACACTGATGGAGTATTTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAA
ATGATCTTTGTCGGCATTAAGAAGAAGGAAGAAAGGGCAGACTTAATAGCTTATCTCAAA
AAAGCTACTAATGAGTAA
Chromosome Location
7
Locus
7p15.2
External Identifiers
ResourceLink
UniProtKB IDP99999
UniProtKB Entry NameCYC_HUMAN
GenBank Protein ID181242
GenBank Gene IDM22877
GenAtlas IDCYCS
HGNC IDHGNC:19986
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01017Minocyclineapproved, investigationalunknownnegative modulatorDetails
DB02110Protoporphyrin Ix Containing CoexperimentalunknownDetails
DB03934Protoporphyrin Ix Containing ZnexperimentalunknownDetails
DB03317Heme CexperimentalunknownDetails
DB03366Imidazoleexperimental, investigationalunknownDetails
DB03977N-TrimethyllysineexperimentalunknownDetails
DB04249Zinc Substituted Heme CexperimentalunknownDetails
DB11638Artenimolexperimental, investigationalunknownligandDetails