Potassium voltage-gated channel subfamily V member 1
Details
- Name
- Potassium voltage-gated channel subfamily V member 1
- Synonyms
- Neuronal potassium channel alpha subunit HNKA
- Voltage-gated potassium channel subunit Kv8.1
- Gene Name
- KCNV1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052269|Potassium voltage-gated channel subfamily V member 1 MPSSGRALLDSPLDSGSLTSLDSSVFCSEGEGEPLALGDCFTVNVGGSRFVLSQQALSCF PHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYFFDRSSQAFRYVLHYYRTG RLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKKDTEDQESQHES EQDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVVVSIINMALMSAELSWLDLQ LLEILEYVCISWFTGEFVLRFLCVRDRCRFLRKVPNIIDLLAILPFYITLLVESLSGSQT TQELENVGRIVQVLRLLRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIF STVEYFAEQSIPDTTFTSVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVL ALPIAIINDRFSACYFTLKLKEAAVRQREALKKLTKNIATDSYISVNLRDVYARSIMEML RLKGRERASTRSSGGDDFWF
- Number of residues
- 500
- Molecular Weight
- 56303.305
- Theoretical pI
- Not Available
- GO Classification
- Functionsion channel inhibitor activity / potassium channel regulator activity / voltage-gated potassium channel activityProcessespotassium ion transmembrane transport / potassium ion transport / protein homooligomerization / regulation of ion transmembrane transportComponentsintegral component of membrane / integral component of plasma membrane / plasma membrane / voltage-gated potassium channel complex
- General Function
- Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.
- Specific Function
- Ion channel inhibitor activity
- Pfam Domain Function
- Transmembrane Regions
- 211-231 239-259 277-297 310-331 346-366 407-427
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052270|Potassium voltage-gated channel subfamily V member 1 (KCNV1) ATGCCTTCCAGCGGCAGAGCGCTGCTGGACTCGCCGCTGGACAGCGGCTCCCTGACCTCC CTGGACTCTAGTGTCTTCTGCAGCGAGGGTGAAGGGGAGCCCTTGGCGCTCGGGGACTGC TTCACGGTCAACGTGGGCGGCAGCCGCTTCGTGCTCTCGCAGCAGGCGCTGTCCTGCTTC CCGCACACGCGCCTTGGCAAGCTGGCCGTGGTGGTGGCTTCCTACCGCCGCCCCGGGGCC CTGGCCGCCGTGCCCAGCCCTCTGGAGCTTTGCGACGATGCCAACCCCGTGGACAACGAG TACTTCTTCGACCGCAGCTCGCAGGCGTTCCGATATGTCCTGCACTACTACCGCACCGGC CGCCTGCATGTCATGGAGCAGCTGTGCGCGCTCTCCTTCCTGCAGGAGATCCAGTACTGG GGCATCGATGAGCTCAGCATCGATTCCTGCTGCAGGGACAGATACTTCAGAAGGAAAGAG CTGAGTGAAACTTTAGACTTCAAGAAGGACACAGAAGACCAGGAAAGTCAACATGAGAGT GAACAGGACTTCTCCCAAGGACCTTGTCCCACTGTTCGCCAGAAGCTCTGGAATATCCTG GAGAAACCTGGATCTTCCACAGCTGCCCGTATCTTTGGCGTCATCTCCATTATCTTCGTG GTGGTGTCCATCATTAACATGGCCCTGATGTCAGCTGAGTTAAGCTGGCTGGACCTGCAG CTGCTGGAAATCCTGGAGTATGTGTGCATTAGCTGGTTCACCGGGGAGTTTGTCCTCCGC TTCCTGTGTGTGCGGGACAGGTGTCGCTTCCTAAGAAAGGTGCCAAACATCATAGACCTC CTTGCCATCTTGCCCTTCTACATCACTCTTCTGGTAGAGAGCCTAAGTGGGAGCCAGACC ACGCAGGAGCTGGAGAACGTGGGGCGCATTGTCCAGGTGTTGAGGCTGCTCAGGGCTCTG CGCATGCTAAAGCTGGGCAGACATTCCACAGGATTACGCTCCCTTGGGATGACAATCACC CAGTGTTACGAAGAAGTCGGCCTACTGCTCCTATTTCTATCCGTGGGAATCTCTATATTT TCAACTGTAGAATACTTTGCTGAGCAAAGCATTCCTGACACAACCTTCACAAGTGTCCCT TGTGCATGGTGGTGGGCCACCACCTCTATGACTACTGTGGGATATGGGGACATTAGACCA GACACCACCACAGGCAAAATCGTGGCCTTCATGTGTATATTATCGGGAATTCTTGTCTTG GCCTTGCCTATTGCTATTATTAACGATCGCTTCTCTGCTTGCTACTTCACCTTGAAACTC AAGGAAGCAGCTGTTAGACAGCGTGAAGCCCTAAAGAAGCTTACCAAGAATATAGCCACT GACTCATATATCAGTGTTAACTTGAGAGATGTCTATGCCCGGAGTATCATGGAGATGCTG CGACTGAAAGGCAGAGAAAGAGCAAGTACTAGGAGCAGCGGGGGAGATGATTTCTGGTTT TGA
- Chromosome Location
- 8
- Locus
- 8q23.2
- External Identifiers
Resource Link UniProtKB ID Q6PIU1 UniProtKB Entry Name KCNV1_HUMAN HGNC ID HGNC:18861 - General References
- Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattei MG, Lazdunski M: Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. EMBO J. 1996 Jul 1;15(13):3322-31. [Article]
- Sano A, Mikami M, Nakamura M, Ueno S, Tanabe H, Kaneko S: Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy. Epilepsia. 2002;43 Suppl 9:26-31. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Salinas M, de Weille J, Guillemare E, Lazdunski M, Hugnot JP: Modes of regulation of shab K+ channel activity by the Kv8.1 subunit. J Biol Chem. 1997 Mar 28;272(13):8774-80. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00228 Enflurane approved, investigational, vet_approved unknown inhibitoractivator Details DB01069 Promethazine approved, investigational unknown inducer Details DB01110 Miconazole approved, investigational, vet_approved unknown inhibitor Details