Miconazole - DrugBank

ID Pharmacology Interactions References Trials Economics Properties Spectra Taxonomy

Targets (15)Enzymes (10)Transporters (1)

Targets (15)Enzymes (10)Transporters (1)Biointeractions (20)

Identification

Name

Miconazole

Accession Number

DB01110 (APRD01115)

Type

Small Molecule

Groups

Approved, Investigational, Vet Approved

Description

An imidazole antifungal agent that is used topically and by intravenous infusion. [PubChem]

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole

1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole

Daktarin iv

Miconazole

Monistat iv (tn)

External IDs

Not Available

Product Ingredients

Ingredient	UNII	CAS	InChI Key	Details
Miconazole nitrate	VW4H1CYW1K	22832-87-7	MCCACAIVAXEFAL-UHFFFAOYSA-N	Details

Approved Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Oravig	Tablet	50 mg/1	Buccal	Praelia Pharmaceuticals Inc	2012-11-01	2015-12-29	US
Oravig	Tablet	50 mg/1	Buccal	Midatech Pharma Us, Inc.	2010-04-16	Not applicable	US

Approved Generic Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Miconazole Nitrate	Suppository	200 mg/1	Vaginal	Actavis Pharma Company	2002-09-03	Not applicable	US

Approved Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
3m Cavilon Antifungal	Cream	2 g/1000g	Topical	3 M Pharmaceuticals	2010-11-30	Not applicable	US
7 Day Vaginal	Cream	2 g/100g	Topical	Cardinal Health	2009-03-16	Not applicable	US
Aloe Vesta Antifungal	Ointment	20 mg/g	Topical	Convatec Inc.	1997-10-03	Not applicable	US
Aloe Vesta Clear Antifungal	Ointment	2 g/100g	Topical	Convatec Inc.	2013-12-20	Not applicable	US
Aloe Vesta Clear Antifungal 141g	Ointment	2.82 g/141g	Topical	Guest Packaging Llc.	2016-06-09	Not applicable	US
Aloe Vesta Clear Antifungal 56g	Ointment	1.12 g/56g	Topical	Guest Packaging Llc.	2016-06-09	Not applicable	US
Anti-fungal	Cream	.02 g/g	Topical	Universal Distribution Center LLC	2015-04-15	Not applicable	US
Antifungal	Cream	20 mg/g	Topical	A S Medication Solutions	2007-05-01	2017-06-20	US
Antifungal	Cream	20 mg/g	Topical	A S Medication Solutions	2007-05-01	2017-06-20	US
Antifungal	Cream	20 mg/g	Topical	Actavis Pharma Company	2007-05-01	Not applicable	US
Antifungal	Cream	20 mg/g	Topical	Preferreed Pharmaceuticals Inc.	2016-08-25	Not applicable	US
Antifungal	Cream	20 mg/g	Topical	PSS World Medical, Inc.	2012-09-05	Not applicable	US
Antifungal	Cream	2 mg/100mL	Topical	Mc Kesson	2017-05-26	Not applicable	US
Antifungal Body	Cream	2 mg/100mL	Topical	Mc Kesson	2017-06-01	Not applicable	US
Antifungal Skin Care Cvs	Kit			Product Quest Mfg.	2016-04-14	2016-12-13	US
Athlet Foot Well At Walgreens	Powder	2 g/100mL	Topical	Walgreens	2015-04-15	Not applicable	US
Athletes Foot	Spray	2 g/100g	Topical	Walgreen	2005-06-09	Not applicable	US
Athletes Foot	Spray	2 g/100g	Topical	Walgreen	2005-06-09	Not applicable	US
Athletes Foot Spray	Spray	2 g/100g	Topical	Cvs Health	2006-03-02	Not applicable	US
Azolen	Tincture	20 mg/mL	Topical	Stratus Pharmaceuticals	2011-12-01	Not applicable	US
Baza Antifungal	Cream	20 mg/g	Topical	Coloplast Corp.	2009-06-15	Not applicable	US
Bf-micozo	Cream	20 mg/g	Topical	Bright Future Pharmaceuticals Factory	2011-03-08	Not applicable	US
Budpak Antifungal Miconazole Nitrate	Cream	.02 g/g	Topical	Budpak Inc.	2013-11-29	Not applicable	US
Care One Miconazole 1	Kit			American Sales Company	2010-11-19	Not applicable	US
Care One Miconazole 3	Kit			American Sales Company	2004-07-27	Not applicable	US
Care One Miconazole 7	Cream	2 g/100g	Vaginal	American Sales Company	1999-10-11	Not applicable	US
Careone Miconazole 3	Kit			American Sales Company	2014-04-13	Not applicable	US
Careone Miconazole 3	Kit			American Sales Company	2016-10-17	Not applicable	US
Carrington Antifungal	Cream	20 mg/g	Topical	Medline Industries	2007-01-01	Not applicable	US
Clearly Confident	Cream	20 mg/g	Topical	Ganeden Biotech, Inc.	2013-12-17	Not applicable	US
Conazol	Cream	20 mg/g	Topical	Marcas Usa Llc	2014-08-01	Not applicable	US
Conazol	Spray	20 mg/g	Topical	Marcas Usa Llc	2014-06-25	Not applicable	US
Critic Aid Clear AF	Ointment	20 mg/g	Topical	Coloplast Corp.	2009-06-15	Not applicable	US
Db Antifungal Foot	Cream	20 mg/g	Topical	The Magni Group Inc	2017-04-27	Not applicable	US
Dermagungal	Cream	.02 g/100g	Topical	Dermarite Industries, Llc	2005-12-12	Not applicable	US
Desenex	Powder	2 g/100g	Topical	Novartis	2009-08-03	Not applicable	US
DG Health Miconazole	Cream	2 g/100g	Vaginal	Dolgencorp	2010-01-17	Not applicable	US
Dg Health Miconazole 3	Kit			Dolgencorp	2010-02-22	Not applicable	US
Dynarex Antifungal Powder	Powder	20 mg/g	Topical	Dynarex Corporation	2016-05-19	Not applicable	US
Elta Trivase	Cream	20 g/1000g	Topical	Swiss American Products	2002-04-30	Not applicable	US
Equaline Athletes Foot	Spray	2 g/100g	Topical	Supervalu	2004-09-11	Not applicable	US
Equaline Miconazole 1	Kit			Supervalu	2010-06-11	Not applicable	US
Equaline Miconazole 1	Kit			Supervalu	2010-06-11	Not applicable	US
Equaline Miconazole 3	Kit			Supervalu	2012-01-16	Not applicable	US
Equaline Miconazole 3	Kit			Supervalu	2006-03-16	Not applicable	US
Equaline Miconazole 7	Cream	2 g/100g	Vaginal	Supervalu	2004-11-10	Not applicable	US
Equate Athletes Foot	Spray	2 g/100g	Topical	Walmart Stores	2011-09-18	Not applicable	US
Equate Miconazole 1	Kit			Walmart Stores	2013-08-12	Not applicable	US
Equate Miconazole 1	Kit			Walmart Stores	2010-06-09	Not applicable	US
Exchange Select Miconazole 1	Kit			Army + Air Force Exchange Service	2016-03-25	Not applicable	US
Family Wellness Miconazole 3	Kit			Family Dollar Services	2013-03-29	Not applicable	US
Femmesil Creme Maximum Strength	Cream	2 g/100g	Topical	Aidance Skincare & Topical Solutions, LLC	2012-09-07	Not applicable	US
Femmesil Maximum Strength	Ointment	2 g/100g	Topical	Aidance Skincare & Topical Solutions, LLC	2012-09-07	Not applicable	US
Foot Silka	Powder	2 g/100mL	Topical	Genomma Lab	2016-02-25	Not applicable	US
Fungoid Tincture	Tincture	20 mg/mL	Topical	Pedinol Pharmacal, Inc.	1994-01-01	Not applicable	US
Fungoid Tincture Treatment Kit	Kit			Pedinol Pharmacal, Inc.	1994-01-01	Not applicable	US
Genrx Daily Defense Antifungal	Cream	20 mg/mL	Topical	Pure Tek Corporation	2013-01-08	Not applicable	US
Genrx Daily Defense Antifungal	Powder	20 mg/g	Topical	Pure Tek Corporation	2013-01-08	Not applicable	US
Good Neighbor Pharmacy Athletes Foot Relief	Spray	2 g/100g	Topical	Amerisource Bergen	2017-04-03	Not applicable	US
Good Neighbor Pharmacy Athletes Foot Relief Antifungal	Spray	20 mg/g	Topical	Formulated Solutions, Llc	2017-01-20	Not applicable	US
Good Neighbor Pharmacy Jock Itch Relief	Spray	2 g/100g	Topical	Amerisource Bergen	2017-04-06	Not applicable	US
Good Neighbor Pharmacy Jock Itch Relief Antifungal	Spray	20 mg/g	Topical	Formulated Solutions, Llc	2017-02-09	Not applicable	US
Good Neighbor Pharmacy Miconazole 1	Kit			Amerisource Bergen	2010-06-11	Not applicable	US
Good Neighbor Pharmacy Miconazole 3	Kit			Amerisource Bergen	2012-09-04	Not applicable	US
Good Neighbor Pharmacy Miconazole 7	Cream	2 g/100g	Vaginal	Amerisource Bergen	1999-10-11	Not applicable	US
Good Neighbor Pharmacy Miconazole Nitrate	Kit			Amerisource Bergen	2000-05-02	Not applicable	US
Good Sense Miconazole 1	Kit			L. Perrigo Company	2010-06-29	Not applicable	US
Good Sense Miconazole 3	Kit			L. Perrigo Company	2007-04-02	Not applicable	US
Good Sense Miconazole 3	Kit			L. Perrigo Company	2000-02-25	Not applicable	US
Good Sense Miconazole 7	Cream	2 g/100g	Vaginal	L. Perrigo Company	2000-02-22	Not applicable	US
Good Sense Miconazole 7	Cream	2 g/100g	Vaginal	L. Perrigo Company	1999-07-30	Not applicable	US
Green Tetterine	Ointment	2 g/100g	Topical	S.S.S. Company	1994-07-31	Not applicable	US
Harris Teeter Miconazole 3	Kit			Harris Teeter	2015-11-21	Not applicable	US
Harris Teeter Miconazole 7	Cream	2 g/100g	Vaginal	Harris Teeter	2015-11-21	Not applicable	US
Healthy Accents Miconazole 3	Kit			Dza Brands,	2008-04-01	Not applicable	US
Healthy Accents Miconazole 7	Cream	2 g/100g	Vaginal	Dza Brands,	2008-03-03	Not applicable	US
Healthy Accents Miconazole 7	Cream	2 g/100g	Vaginal	Dza Brands,	2014-12-03	Not applicable	US
Hongo Killer	Aerosol, spray	.2 g/10g	Topical	Efficient Laboratories, Inc.	2004-10-01	Not applicable	US
Image Essentials Miconazole Treatment	Kit			Kmart Corporation	2015-02-04	Not applicable	US
Image Essentials Miconazole Treatment	Kit			Kmart Corporation	2014-12-03	Not applicable	US
Image Essentials Miconazole Treatment	Kit			Kmart Corporation	2015-08-20	Not applicable	US
Image Essentials Miconazole Treatment	Kit			Kmart Corporation	2015-02-24	Not applicable	US
Image Essentials Miconazole Treatment	Kit			Kmart Corporation	2015-08-20	Not applicable	US
Jock Itch Relief	Spray	2 g/100g	Topical	Meijer Distribution	2017-03-29	Not applicable	US
Kaiser Permanente Miconazole Nitrate	Cream	20 mg/g	Topical	Kaiser Foundations Hospitals	1991-10-01	Not applicable	US
Kendall Antifungal	Cream	2 g/100g	Topical	Covidien	2011-04-14	Not applicable	US
Lagicam Antifungal	Cream	40 mg/g	Vaginal	Genomma Lab	2005-03-02	Not applicable	US
Leader Medicated	Powder	1.42 g/71g	Topical	Cardinal Health	2010-10-31	Not applicable	US
Leader Medicated	Aerosol, spray	2.6 g/130g	Topical	Cardinal Health	2010-03-15	Not applicable	US
Leader Miconazole 1	Kit			Cardinal Health	2011-01-19	Not applicable	US
Lotrimin AF Antifungal	Spray	20 mg/g	Topical	Bayer	1993-09-01	Not applicable	US
Lotrimin Antifungal	Aerosol, powder	20 mg/g	Topical	Bayer	1993-09-01	Not applicable	US
Lotrimin Antifungal	Aerosol, powder	20 mg/g	Topical	Bayer Healthcare Llc.	1993-09-01	Not applicable	US
Lotrimin Antifungal	Powder	20 mg/g	Topical	Bayer	1993-09-01	Not applicable	US
Lotrimin Antifungal	Aerosol, powder	20 mg/g	Topical	Bayer	1993-09-01	Not applicable	US
Macerrx Web	Cream	2 g/100g	Topical	Clinical Therapeutic Solutions	2013-06-06	Not applicable	US
Makesense	Cream	2 g/100g	Topical	Cherry Hill Sales Co	2014-07-15	Not applicable	US
Medicated Anti-fungal Miconazole	Liquid	2 g/100g	Topical	American Spraytech, Llc	2010-06-02	Not applicable	US
Meijer Jock Itch Relief Antifungal	Spray	20 mg/g	Topical	Formulated Solutions, Llc	2017-01-20	Not applicable	US
Meijer Miconazole 3	Cream	40 mg/g	Vaginal	Meijer Distribution	2005-03-02	Not applicable	US
Micatin	Cream	20 mg/g	Topical	Well Spring Pharmaceutical Corporation	2009-06-24	Not applicable	US
Micatin Cream - 2%	Cream	2 %	Topical	Well Spring Pharmaceutical Corporation	1974-12-31	Not applicable	Canada
Micatin Powder Spray - Unscented 2%	Aerosol	2 %	Topical	Well Spring Pharmaceutical Corporation	1997-06-16	Not applicable	Canada
Miconazole	Cream	20 mg/g	Topical	Kinray	2013-03-21	Not applicable	US
Miconazole	Cream	2 g/100g	Topical	Chain Drug Consortium	2009-05-15	Not applicable	US
Miconazole	Cream	20 mg/g	Topical	Galentic Pharma (India) Private Limited	2013-07-18	Not applicable	US
Miconazole 1	Kit			Meijer Distribution	2010-06-11	Not applicable	US
Miconazole 1	Kit			Cvs Health	2010-06-08	Not applicable	US
Miconazole 1	Kit			Walgreen	2011-12-15	Not applicable	US
Miconazole 1	Kit			Safeway	2010-08-30	Not applicable	US
Miconazole 1	Kit			Meijer Distribution	2010-06-09	Not applicable	US
Miconazole 1	Kit			Rite Aid	2010-06-16	Not applicable	US
Miconazole 1	Kit			Kroger	2010-06-08	Not applicable	US
Miconazole 1	Kit			Hyvee	2010-06-13	Not applicable	US
Miconazole 1	Kit			Western Family Foods	2011-07-11	Not applicable	US
Miconazole 1	Kit			Walgreen	2010-06-10	Not applicable	US
Miconazole 1	Kit			Kroger	2013-07-23	Not applicable	US
Miconazole 1	Kit			H.E.B.	2010-06-07	Not applicable	US
Miconazole 1	Kit			H.E.B.	2010-06-07	Not applicable	US
Miconazole 1	Kit			Meijer Distribution	2010-06-09	Not applicable	US
Miconazole 1	Kit			Walgreen	2010-06-08	Not applicable	US
Miconazole 1	Kit			Rite Aid	2010-06-09	Not applicable	US
Miconazole 1	Kit			Hyvee	2010-06-13	Not applicable	US
Miconazole 1 Feminine Care	Kit			Rite Aid	2010-06-09	Not applicable	US
Miconazole 1 Yeast Infection Relief	Kit			Cvs Health	2010-06-08	Not applicable	US
Miconazole 3	Kit			Meijer Distribution	2016-10-12	Not applicable	US
Miconazole 3	Kit			Walgreen	2005-07-08	Not applicable	US
Miconazole 3	Kit			Walgreen	2006-09-06	Not applicable	US
Miconazole 3	Kit			Walgreen	2004-07-19	Not applicable	US
Miconazole 3	Kit			Kroger	2004-08-17	Not applicable	US
Miconazole 3	Kit			Rite Aid	2014-02-12	Not applicable	US
Miconazole 3	Kit			H.E.B.	2006-03-14	Not applicable	US
Miconazole 3	Kit			Walgreen	2005-07-01	Not applicable	US
Miconazole 3	Kit			Kroger	2000-02-23	Not applicable	US
Miconazole 3	Kit			Rite Aid	2006-08-18	Not applicable	US
Miconazole 3	Cream	40 mg/g	Vaginal	Shopko Stores Operating	2005-03-02	Not applicable	US
Miconazole 3	Kit			Hyvee	2009-07-01	Not applicable	US
Miconazole 3	Kit			Cvs Health	2014-02-28	Not applicable	US
Miconazole 3	Kit		Topical; Vaginal	Cvs Health	1996-04-16	Not applicable	US
Miconazole 3	Kit			Meijer Distribution	2000-02-04	Not applicable	US
Miconazole 3	Kit			Western Family Foods	2005-01-21	Not applicable	US
Miconazole 3 Combination Pack	Kit		Vaginal	Cardinal Health	2002-12-02	Not applicable	US
Miconazole 3 Combination Pack	Kit			Fred's	2009-06-09	Not applicable	US
Miconazole 3 Combination Pack	Kit			Walmart Stores	2007-06-11	Not applicable	US
Miconazole 3 Combination Pack	Kit			Rite Aid	2001-03-01	Not applicable	US
Miconazole 3 Combination Pack	Kit		Vaginal	Cardinal Health	2001-02-02	Not applicable	US
Miconazole 3 Combination Pack	Kit			Cvs Health	2001-03-01	Not applicable	US
Miconazole 3 Combination Pack	Kit			Chain Drug Consortium	2003-09-11	Not applicable	US
Miconazole 3 Combination Pack	Kit			Wakfern Food Corporation	2007-05-29	Not applicable	US
Miconazole 3 Combination Pack	Kit		Vaginal	Major	2002-12-02	Not applicable	US
Miconazole 3 Day	Kit			Publix Supermarkets, Inc.	2009-06-26	Not applicable	US
Miconazole 3 Day Ovule Treatment 400mg	Suppository	400 mg	Vaginal	Vita Health Products Inc	1996-12-31	Not applicable	Canada
Miconazole 7	Suppository	100 mg/1	Vaginal	Mc Kesson	2011-12-09	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Western Family Foods	1999-10-08	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Safeway	1999-09-08	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Actavis Pharma Company	2011-09-16	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Kroger	1999-04-28	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Hyvee	2000-02-15	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Meijer Distribution	2000-02-04	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Fred's	2009-06-09	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Exchange Select	2002-07-12	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Walmart Stores	2008-03-03	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Major	2009-04-21	Not applicable	US
Miconazole 7	Cream	2 mg/100g	Vaginal	Shopko Stores Operating	1997-01-13	Not applicable	US
Miconazole 7	Suppository	100 mg/1	Vaginal	Actavis Pharma Company	1993-11-19	Not applicable	US
Miconazole 7	Cream	20 mg/g	Vaginal	Preferreed Pharmaceuticals Inc.	2012-07-27	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Western Family Foods	2011-08-10	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Walgreen	2000-12-01	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Rite Aid	2001-03-01	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Remedy Repack	2016-10-06	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	A S Medication Solutions	2009-04-21	2017-06-20	US
Miconazole 7	Cream	2 g/100g	Vaginal	Cvs Health	1999-09-02	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	H.E.B.	2006-01-09	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Cvs Health	2009-09-15	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Cardinal Health (Leader)	2014-05-31	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Family Dollar Services	2006-06-06	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Chain Drug Consortium	2003-09-11	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Kroger	2002-07-15	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Chain Drug Marketing Association	2010-07-01	Not applicable	US
Miconazole 7	Cream	2 g/100g	Vaginal	Rexall	2010-07-01	Not applicable	US
Miconazole 7 - Crm Vag 2%	Cream	2 %	Vaginal	Technilab Pharma Inc.	1996-11-04	2005-08-05	Canada
Miconazole Nitrate	Cream	20 mg/g	Vaginal	A S Medication Solutions	1996-02-22	2017-06-20	US
Miconazole Nitrate	Powder	1.42 g/71g	Topical	Chain Drug Consortium	2011-06-10	Not applicable	US
Miconazole Nitrate	Aerosol, spray	3 g/150g	Topical	Premier Brands of America Inc.	2013-01-01	Not applicable	US
Miconazole Nitrate	Aerosol, powder	2.6 g/130g	Topical	Cvs Health	2014-01-01	Not applicable	US
Miconazole Nitrate	Aerosol, spray	3 g/150g	Topical	Harmon Store Inc.	2012-01-17	Not applicable	US
Miconazole Nitrate	Powder	1.42 g/71g	Topical	Amerisource Bergen Drug Corportaion	2012-01-10	Not applicable	US
Miconazole Nitrate	Aerosol, spray	3 g/150g	Topical	Chain Drug Consortium	2010-01-05	Not applicable	US
Miconazole Nitrate	Aerosol, spray	2.6 g/130g	Topical	Topco Associates	2012-01-03	Not applicable	US
Miconazole Nitrate	Cream	20 mg/g	Topical	Rebel Distributors	2003-09-01	Not applicable	US
Miconazole Nitrate	Aerosol, spray	1.3 g/131g	Topical	Dolgencorp, Inc. (Dollar General & Rexall)	2013-05-13	Not applicable	US
Miconazole Nitrate	Cream	20 mg/g	Topical	Physicians Total Care, Inc.	2012-03-20	Not applicable	US
Miconazole Nitrate	Powder	1.42 g/71g	Topical	Cvs Health	2014-01-01	Not applicable	US
Miconazole Nitrate	Aerosol, powder	2.6 g/130g	Topical	Walmart Stores	2014-02-25	Not applicable	US
Miconazole Nitrate	Cream	20 mg/g	Topical	A S Medication Solutions	2003-09-01	2017-03-31	US
Miconazole Nitrate	Spray	3 g/150g	Topical	Walgreens	2010-05-18	Not applicable	US
Miconazole Nitrate	Powder	1.42 g/71g	Topical	Cvs Health	2012-01-04	Not applicable	US
Miconazole Nitrate	Powder	1.42 g/71g	Topical	Harmon Store Inc.	2017-04-15	Not applicable	US
Miconazole Nitrate	Cream	20 mg/g	Vaginal	Taro Pharmaceuticals U.S.A., Inc.	1997-01-13	Not applicable	US
Miconazole Nitrate	Aerosol, spray	3 g/150g	Topical	Meijer Distribution	2012-04-13	Not applicable	US
Miconazole Nitrate	Cream	20 mg/g	Topical	A S Medication Solutions	1991-10-01	2017-06-20	US
Miconazole Nitrate	Aerosol, powder	2.6 g/130g	Topical	Premier Brands of America Inc.	2013-01-01	Not applicable	US
Miconazole Nitrate	Cream	20 mg/g	Vaginal	Rebel Distributors	2008-01-01	Not applicable	US
Miconazole Nitrate	Suppository	100 ug/1	Vaginal	Gw Pharmaceuticals Ltd.	1997-04-30	Not applicable	US
Miconazole Nitrate	Cream	20 mg/g	Vaginal	Preferreed Pharmaceuticals Inc.	2016-02-01	Not applicable	US
Miconazole Nitrate	Aerosol, powder	2.6 g/130g	Topical	Cvs Health	2017-05-22	Not applicable	US
Miconazole Nitrate	Aerosol, spray	3 g/150g	Topical	Cvs Health	2014-01-01	Not applicable	US
Miconazole Nitrate	Cream	20 mg/g	Topical	Preferreed Pharmaceuticals Inc.	2014-09-02	Not applicable	US
Miconazole Nitrate	Cream	40 mg/g	Vaginal	Taro Pharmaceuticals U.S.A., Inc.	2005-03-02	Not applicable	US
Miconazole Nitrate	Powder	1.42 g/71g	Topical	Meijer Distribution	2012-03-06	Not applicable	US
Miconazole Nitrate	Powder	1.42 g/71g	Topical	Premier Brands of America Inc.	2013-01-01	Not applicable	US
Miconazole Nitrate	Powder	1.42 g/71g	Topical	Harmon Store Inc.	2014-01-27	Not applicable	US
Miconazole Nitrate	Suppository	100 ug/1	Vaginal	Rebel Distributors	1997-04-30	Not applicable	US
Miconazole Nitrate	Cream	20 mg/g	Topical	Qualitest	2003-09-01	2017-03-31	US
Miconazole Nitrate	Aerosol, powder	2.6 g/130g	Topical	Premier Brands of America Inc.	2013-01-01	Not applicable	US
Miconazole Nitrate	Aerosol, spray	1.3 g/130g	Topical	Cvs Health	2017-06-10	Not applicable	US
Miconazole Nitrate	Aerosol, spray	1.3 g/131g	Topical	Cvs Health	2014-01-01	Not applicable	US
Miconazole Nitrate	Cream	20 mg/g	Vaginal	Gw Pharmaceuticals Ltd.	1996-02-22	Not applicable	US
Miconazole Nitrate	Cream	20 mg/g	Vaginal	Central Texas Community Health Centers	1996-02-22	Not applicable	US
Miconazole Nitrate	Cream	20 mg/g	Topical	Taro Pharmaceuticals U.S.A., Inc.	1991-10-01	Not applicable	US
Miconazole Nitrate	Powder	1.42 g/71g	Topical	Cvs Health	2017-04-03	Not applicable	US
Miconazole Nitrate	Powder	1.42 g/71g	Topical	Cvs Health	2014-01-01	Not applicable	US
Miconazole Nitrate 2% Cream Antifungal	Cream	2 g/100g	Topical	Trifecta Pharmaceuticals Usa, Llc.	2016-03-22	Not applicable	US
Miconazole Nitrate Vaginal Cream 2%	Cream	2 %	Vaginal	Vita Health Products Inc	2003-03-13	Not applicable	Canada
Miconazole Nitrate Vaginal Cream USP, 2%	Cream	2 %	Vaginal	Taro Pharmaceuticals, Inc.	1997-08-12	Not applicable	Canada
Miconole	Cream	20 mg/g	Topical	Option Labs	2013-10-15	Not applicable	US
Micozole	Cream	2 %	Vaginal	Taro Pharmaceuticals, Inc.	1997-08-11	Not applicable	Canada
Micro-guard (af)	Powder	20 mg/g	Topical	Coloplast Corp.	2009-06-15	Not applicable	US
Molecular AF Molecular Cream	Cream	.3 g/14g	Topical	Renu Laboratories, Inc.	2015-03-31	Not applicable	US
Monazole 7 - Crm 20mg/g	Cream	20 mg	Vaginal	Technilab Pharma Inc.	1997-01-21	2001-09-05	Canada
Monistat 1 Combination Pack	Kit			Insight Pharmaceuticals	2001-06-29	Not applicable	US
Monistat 1 Combination Pack	Kit			Insight Pharmaceuticals	2001-06-29	Not applicable	US
Monistat 1 Combination Pack Triple Action	Kit			Insight Pharmaceuticals	2001-06-29	Not applicable	US
Monistat 1 Vaginal Ovule	Suppository	1200 mg	Vaginal	Insight Pharmaceuticals	1999-02-26	Not applicable	Canada
Monistat 3 3-day Pre-filled Applicators	Cream	40 mg/g	Vaginal	Insight Pharmaceuticals	1998-03-30	Not applicable	US
Monistat 3 Combination Pack	Kit			Insight Pharmaceuticals	2009-12-10	Not applicable	US
Monistat 3 Combination Pack	Kit			Insight Pharmaceuticals	1996-04-16	Not applicable	US
Monistat 3 Combination Pack	Kit			Mc Neil, Ppc, Inc.	2009-12-10	2016-11-10	US
Monistat 3 Combination Pack	Kit			Physicians Total Care, Inc.	2012-03-27	Not applicable	US
Monistat 3 Combination Pack	Kit			Mc Neil, Ppc, Inc.	2009-12-10	2016-11-10	US
Monistat 3 Combination Pack 3 Ovule Inserts	Kit			Insight Pharmaceuticals	1996-04-16	Not applicable	US
Monistat 3 Combination Pack Triple Action	Kit			Insight Pharmaceuticals	1996-04-16	Not applicable	US
Monistat 3 Vaginal Cream	Cream	4 %	Vaginal	Insight Pharmaceuticals	2001-10-10	Not applicable	Canada
Monistat 3 Vaginal Ovules	Insert	400 mg	Vaginal	Insight Pharmaceuticals	1981-12-31	Not applicable	Canada
Monistat 7 7-day Disposable Applicators	Cream	20 mg/g	Vaginal	Insight Pharmaceuticals	2010-04-15	Not applicable	US
Monistat 7 Combination Pack 7-day Pre-filled Applicators	Kit			Mc Neil, Ppc, Inc.	2011-10-15	2016-10-13	US
Monistat 7 Combination Pack 7-day Pre-filled Applicators	Kit			Insight Pharmaceuticals	1993-04-26	Not applicable	US
Monistat 7 Combination Pack Triple Action	Kit			Mc Neil, Ppc, Inc.	2010-04-10	2016-10-13	US
Monistat 7 Combination Pack Triple Action	Kit			Insight Pharmaceuticals	1993-04-26	Not applicable	US
Monistat 7 Sup Vag 100mg	Suppository	100 mg	Vaginal	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1978-12-31	2005-07-22	Canada
Monistat 7 Vaginal Cream	Cream	2 %	Vaginal	Insight Pharmaceuticals	1978-12-31	Not applicable	Canada
Monistat 7 With Reusable Applicator	Cream	20 mg/g	Vaginal	Insight Pharmaceuticals	1993-04-26	Not applicable	US
Monistat Derm Cream	Cream	2 %	Topical	Insight Pharmaceuticals	1980-12-31	Not applicable	Canada
Nail Md	Cream	200 mg/mg	Topical	Omg Medical Group, Llc	2013-02-14	Not applicable	US
Novana Antifungal Barrier With Miconazole	Cream	.02 mL/mL	Topical	Novana Medical, Llc	2012-04-04	Not applicable	US
Premier Value Miconazole 3	Cream	40 mg/g	Vaginal	Pharmacy Vlaue Alliance Llc	2005-03-02	Not applicable	US
Previsense Antifungal Moisture Barrier With Protease Technology	Cream	2 g/100g	Topical	Molnlycke Ltd.	2016-04-01	Not applicable	US
Quality Choice 3 Day Vaginal	Cream	40 mg/g	Vaginal	Chain Drug Marketing Association	2005-03-02	Not applicable	US
Remedy Antifungal	Powder	2 g/100g	Topical	Medline Industries	2012-11-19	Not applicable	US
Remedy Antifungal	Powder	2 g/100g	Topical	Medline Industries	2012-11-19	Not applicable	US
Remedy Antifungal Targeted Treatment	Powder	20 mg/g	Topical	Medline Industries	2007-01-01	Not applicable	US
Remedy Antifungal With Olivamine	Cream	2 g/100g	Topical	Medline Industries	2007-01-01	Not applicable	US
Remedy With Phytoplex	Ointment	2 g/100g	Topical	Medline Industries	2016-04-11	Not applicable	US
Remedy With Phytoplex Antifungal Clear	Ointment	2 g/100g	Topical	Medline Industries	2011-08-01	2018-12-31	US
Rexall Miconazole 3	Kit			Dolgencorp	2010-12-14	Not applicable	US
Secura Antifungal Extra Thick	Cream	20 mg/g	Topical	Smith & Nephew, Inc.	2003-08-01	2018-06-30	US
Secura Antifungal Extra Thick	Cream	20 mg/g	Topical	Smith & Nephew, Medical Ltd	2003-08-01	Not applicable	US
Secura Antifungal Greaseless	Cream	20 mg/g	Topical	Smith & Nephew, Inc.	2003-08-01	2018-06-30	US
Secura Antifungal Greaseless	Cream	20 mg/g	Topical	Smith & Nephew, Medical Ltd	2003-08-01	Not applicable	US
Selan Antifungal	Cream	2 g/100g	Topical	Pj Noyes Co. Inc.	2003-11-05	Not applicable	US
Signature Care Athletes Foot	Spray	2 g/100g	Topical	Safeway	2015-10-09	Not applicable	US
Signature Care Athletes Foot	Spray	20 mg/g	Topical	Formulated Solutions, Llc	2017-01-20	Not applicable	US
Signature Care Miconazole 1	Kit			Safeway	2015-09-28	Not applicable	US
Signature Care Miconazole 3	Kit			Safeway	2015-10-06	Not applicable	US
Signature Care Miconazole 3	Kit			Safeway	2015-12-09	Not applicable	US
Signature Care Miconazole 7	Cream	2 g/100g	Vaginal	Safeway	2015-11-03	Not applicable	US
Skin Protector With Breathable Barrier	Cream	2 g/100g	Topical	Diversified Manufacturing Corp	2016-05-04	Not applicable	US
Smart Sense 3 Day Treatment	Kit			Kmart Corporation	2011-05-25	Not applicable	US
Smart Sense 3 Day Treatment Vaginal Antifungal	Kit			Kmart Corporation	2011-05-16	Not applicable	US
Smart Sense 7 Day Treatment	Cream	2 g/100g	Vaginal	Kmart Corporation	2011-02-10	Not applicable	US
Smart Sense Miconazole 1	Kit			Kmart Corporation	2010-06-15	Not applicable	US
Smart Sense Miconazole 1	Kit			Kmart Corporation	2010-06-15	Not applicable	US
Smart Sense Miconazole 1	Kit			Kmart Corporation	2016-08-18	Not applicable	US
Smart Sense Miconazole 1	Kit			Kmart Corporation	2010-06-16	Not applicable	US
Smart Sense Miconazole 1	Kit			Kmart Corporation	2016-08-17	Not applicable	US
Smart Sense Miconazole 3	Kit			Kmart Corporation	2016-08-18	Not applicable	US
Smart Sense Miconazole 3	Kit			Kmart Corporation	2016-06-29	Not applicable	US
Smart Sense Miconazole 7	Cream	2 g/100g	Vaginal	Kmart Corporation	2016-06-24	Not applicable	US
Soothe and Cool Treat	Cream	20 mg/100g	Topical	Medline Industries	2007-01-01	Not applicable	US
Sunmark Antifungal	Cream	20 mg/g	Topical	Mc Kesson	1991-10-01	Not applicable	US
Sunmark Antifungal	Cream	20 mg/g	Topical	A S Medication Solutions	1991-10-01	2017-06-20	US
Sunmark Miconazole 3	Kit			Mc Kesson	2004-07-20	Not applicable	US
Sunmark Miconazole 3	Kit			Mc Kesson	2003-09-05	Not applicable	US
Sunmark Miconazole 3	Kit			Mc Kesson	2003-09-05	Not applicable	US
Sunmark Miconazole 7	Cream	2 g/100g	Vaginal	Mc Kesson	2003-11-25	Not applicable	US
Sunmark Miconazole 7	Cream	2 g/100g	Vaginal	Mc Kesson	2003-07-31	Not applicable	US
Terrasil Rapid-relief Vaginal	Kit			Aidance Skincare & Topical Solutions, LLC	2014-04-18	Not applicable	US
Thera Antifungal Body	Powder	20 mg/g	Topical	Mckesson Medical Surgical	2011-09-01	Not applicable	US
Tineacide Antifungal	Cream	.7 g/35g	Topical	Blaine Labs Inc.	2013-06-01	Not applicable	US
Ting Spray Powder	Aerosol, powder	2.56 g/128g	Topical	Insight Pharmaceuticals	2009-07-16	Not applicable	US
Topcare Miconazole 1	Kit			Topco Associates	2010-06-17	Not applicable	US
Topcare Miconazole 1	Kit			Topco Associates	2010-06-15	Not applicable	US
Topcare Miconazole 3 Combination Pack	Kit			Topco Associates	2000-05-10	Not applicable	US
Topcare Miconazole 3 Combination Pack	Kit			Topco Associates	2004-11-17	Not applicable	US
Topcare Miconazole 3 Yeast Infection Relief	Cream	40 mg/g	Vaginal	Topco Associates	2005-03-02	Not applicable	US
Topcare Miconazole 7	Cream	2 g/100g	Vaginal	Topco Associates	2000-02-29	Not applicable	US
Touchless Care Antifungal	Spray	2 g/100g	Topical	Crawford Healthcare, Inc.	2017-02-28	Not applicable	US
Touchless Care Antifungal	Spray	2 g/100g	Topical	Crawford Healthcare, Inc.	2014-12-29	Not applicable	US
Triple Paste-AF	Ointment	2 g/100g	Topical	Summers Laboratories	2013-10-30	Not applicable	US
Up and Up Jock Itch Relief	Spray	2 g/100g	Topical	Target Corporation.	2013-09-25	Not applicable	US
Up and Up Miconazole	Kit			Target Corporation.	2010-07-08	Not applicable	US
Up and Up Miconazole 1	Kit			Target Corporation.	2010-09-03	Not applicable	US
Up and Up Miconazole 1	Kit			Target Corporation.	2017-01-25	Not applicable	US
Up and Up Miconazole 3	Kit			Target Corporation.	2009-08-17	Not applicable	US
Up and Up Miconazole 3	Kit			Target Corporation.	2009-08-12	Not applicable	US
Up and Up Miconazole 7	Cream	2 g/100g	Vaginal	Target Corporation.	2009-08-26	Not applicable	US
Vagistat-3	Kit			Novartis	2000-02-25	Not applicable	US
Vite20	Liquid	.3 mg/15mL	Topical	Blaine Labs Inc.	2016-04-01	Not applicable	US
Walgreens Medicated Antifungal Athletes Foot	Spray	20 mg/g	Topical	Formulated Solutions, Llc	2017-01-23	Not applicable	US
Welmedix Homecare Pro 2-IN-1 Antifungal and Skin Protectant	Ointment	2 g/100g	Topical	The Akshay Wellness Group, Inc.	2013-04-01	2016-10-13	US
White Tetterine	Ointment	2 g/100g	Topical	S.S.S. Company	1995-02-28	Not applicable	US
Zeasorb	Powder	20.6 mg/g	Topical	Stiefel Laboratories, Inc.	2011-03-14	Not applicable	US
Zeasorb	Powder	20.6 mg/g	Topical	Stiefel Laboratories, Inc.	2011-03-14	Not applicable	US
Zeasorb AF	Powder	20.6 mg/g	Topical	Physicians Total Care, Inc.	2008-03-31	Not applicable	US

Unapproved/Other Products

Not Available

International Brands

Name	Company
Daktarin	Not Available
Decocort	Not Available
Femizol-M	Not Available
Gyno-Daktarin	Not Available
Miconazex	Not Available
Monistat	Not Available
Monistat-Derm	Not Available
Zeasorb-AF	Not Available
Zimycan	Not Available

Brand mixtures

Name	Labeller	Ingredients
Dermasana	Omg Medical Group, Llc	Miconazole Triclosan
Monicure Combo	Insight Pharmaceuticals	Fluconazole Miconazole
Monistat 1 Combination Pack	Insight Pharmaceuticals	Miconazole Miconazole
Monistat 3 Dual-pak	Insight Pharmaceuticals	Miconazole Miconazole
Monistat 7 Dual-pak	Insight Pharmaceuticals	Miconazole Miconazole
Rash Relief Antifungal	Touchless Care Concepts LLC	Dimethicone Miconazole Zinc oxide
Vusion	Prestium Pharma, Inc.	Miconazole Petrolatum Zinc oxide

Categories

UNII

7NNO0D7S5M

CAS number

22916-47-8

Weight

Average: 416.129
Monoisotopic: 413.986023908

Chemical Formula

C₁₈H₁₄Cl₄N₂O

InChI Key

BYBLEWFAAKGYCD-UHFFFAOYSA-N

InChI

InChI=1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2

IUPAC Name

1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole

SMILES

ClC1=CC(Cl)=C(COC(CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=C1

Pharmacology

Indication

For topical application in the treatment of tinea pedis (athlete’s foot), tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis (moniliasis), and in the treatment of tinea versicolor.

Structured Indications

Pharmacodynamics

Miconazole is an anti-fungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). It is used either on the skin or in the vagina for fungal infections. Miconazole was approved by the FDA in 1974. Miconazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.

Mechanism of action

Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

Target	Kind	Pharmacological action	Actions	Organism	UniProt ID
Lanosterol 14-alpha demethylase	Protein	yes	inhibitor	Yeast	P10613	details
Nitric oxide synthase, endothelial	Protein	unknown	inhibitor	Human	P29474	details
Nitric oxide synthase, inducible	Protein	unknown	inhibitor	Human	P35228	details
Calcium-activated potassium channel subunit alpha-1	Protein	unknown	inhibitor	Human	Q12791	details
Calcium-activated potassium channel subunit beta-1	Protein	unknown	inhibitor	Human	Q16558	details
Calcium-activated potassium channel subunit beta-2	Protein	unknown	inhibitor	Human	Q9Y691	details
Calcium-activated potassium channel subunit beta-3	Protein	unknown	inhibitor	Human	Q9NPA1	details
Calcium-activated potassium channel subunit beta-4	Protein	unknown	inhibitor	Human	Q86W47	details
Intermediate conductance calcium-activated potassium channel protein 4	Protein	unknown	inhibitor	Human	O15554	details
Small conductance calcium-activated potassium channel protein 1	Protein	unknown	inhibitor	Human	Q92952	details
Small conductance calcium-activated potassium channel protein 2	Protein	unknown	inhibitor	Human	Q9H2S1	details
Small conductance calcium-activated potassium channel protein 3	Protein	unknown	inhibitor	Human	Q9UGI6	details
Potassium voltage-gated channel subfamily H member 2	Protein	unknown	inhibitor	Human	Q12809	details
Potassium voltage-gated channel subfamily H member 6	Protein	unknown	inhibitor	Human	Q9H252	details
Potassium voltage-gated channel subfamily H member 7	Protein	unknown	inhibitor	Human	Q9NS40	details

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half life

Not Available

Clearance

Not Available

Toxicity

Oral, mouse: LD₅₀ = 3800 mg/kg; Oral, rat: LD₅₀ = 3 gm/kg. Ingestion of the amounts of the components contained in a tube of cream are unlikely to produce overdosage and toxic effects.

Affected organisms

Fungi, yeast and protozoans

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

Drug	Interaction	Drug group
Acebutolol	The serum concentration of Acebutolol can be increased when it is combined with Miconazole.	Approved
Acenocoumarol	The serum concentration of Acenocoumarol can be increased when it is combined with Miconazole.	Approved
Acetaminophen	The serum concentration of Acetaminophen can be increased when it is combined with Miconazole.	Approved
Acetohexamide	Miconazole may increase the hypoglycemic activities of Acetohexamide.	Withdrawn
Acetylsalicylic acid	The serum concentration of Acetylsalicylic acid can be increased when it is combined with Miconazole.	Approved, Vet Approved
Afatinib	The serum concentration of Afatinib can be increased when it is combined with Miconazole.	Approved
Aldosterone	The serum concentration of Aldosterone can be increased when it is combined with Miconazole.	Experimental
Alitretinoin	The serum concentration of Alitretinoin can be increased when it is combined with Miconazole.	Approved, Investigational
Ambrisentan	The serum concentration of Ambrisentan can be increased when it is combined with Miconazole.	Approved, Investigational
Amiodarone	The metabolism of Miconazole can be decreased when combined with Amiodarone.	Approved, Investigational
Amitriptyline	The serum concentration of Amitriptyline can be increased when it is combined with Miconazole.	Approved
Amlodipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Amlodipine.	Approved
Amphotericin B	The therapeutic efficacy of Amphotericin B can be decreased when used in combination with Miconazole.	Approved, Investigational
Amrinone	The risk or severity of adverse effects can be increased when Miconazole is combined with Amrinone.	Approved
Apixaban	The serum concentration of Apixaban can be increased when it is combined with Miconazole.	Approved
Aprepitant	The serum concentration of Miconazole can be increased when it is combined with Aprepitant.	Approved, Investigational
Arsenic trioxide	The serum concentration of Arsenic trioxide can be increased when it is combined with Miconazole.	Approved, Investigational
Artesunate	The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Miconazole resulting in a loss in efficacy.	Approved
Atazanavir	The metabolism of Miconazole can be decreased when combined with Atazanavir.	Approved, Investigational
Atenolol	The serum concentration of Atenolol can be increased when it is combined with Miconazole.	Approved
Atomoxetine	The metabolism of Miconazole can be decreased when combined with Atomoxetine.	Approved
Axitinib	The serum concentration of Axitinib can be increased when it is combined with Miconazole.	Approved, Investigational
Azelnidipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Azelnidipine.	Approved
Azimilide	The risk or severity of adverse effects can be increased when Miconazole is combined with Azimilide.	Investigational
Barnidipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Barnidipine.	Approved
Benidipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Benidipine.	Approved
Bepridil	The risk or severity of adverse effects can be increased when Miconazole is combined with Bepridil.	Approved, Withdrawn
Betamethasone	The serum concentration of Betamethasone can be increased when it is combined with Miconazole.	Approved, Vet Approved
Bexarotene	The serum concentration of Miconazole can be decreased when it is combined with Bexarotene.	Approved, Investigational
Boceprevir	The metabolism of Miconazole can be decreased when combined with Boceprevir.	Approved, Investigational
Bortezomib	The metabolism of Miconazole can be decreased when combined with Bortezomib.	Approved, Investigational
Bosentan	The serum concentration of Miconazole can be decreased when it is combined with Bosentan.	Approved, Investigational
Bosutinib	The serum concentration of Bosutinib can be increased when it is combined with Miconazole.	Approved
Brentuximab vedotin	The serum concentration of Brentuximab vedotin can be increased when it is combined with Miconazole.	Approved
Bromocriptine	The serum concentration of Bromocriptine can be increased when it is combined with Miconazole.	Approved, Investigational
Buspirone	The metabolism of Buspirone can be decreased when combined with Miconazole.	Approved, Investigational
Busulfan	The serum concentration of Busulfan can be increased when it is combined with Miconazole.	Approved, Investigational
Cabazitaxel	The serum concentration of Cabazitaxel can be increased when it is combined with Miconazole.	Approved
Caffeine	The serum concentration of Caffeine can be increased when it is combined with Miconazole.	Approved
Camptothecin	The serum concentration of Camptothecin can be increased when it is combined with Miconazole.	Experimental
Canagliflozin	The serum concentration of Canagliflozin can be increased when it is combined with Miconazole.	Approved
Carbamazepine	The metabolism of Miconazole can be increased when combined with Carbamazepine.	Approved, Investigational
Carfilzomib	The serum concentration of Carfilzomib can be increased when it is combined with Miconazole.	Approved
Ceritinib	The serum concentration of Miconazole can be increased when it is combined with Ceritinib.	Approved
Cerivastatin	The serum concentration of Cerivastatin can be increased when it is combined with Miconazole.	Withdrawn
Chlorpromazine	The serum concentration of Chlorpromazine can be increased when it is combined with Miconazole.	Approved, Vet Approved
Chlorpropamide	Miconazole may increase the hypoglycemic activities of Chlorpropamide.	Approved
Cilnidipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Cilnidipine.	Approved
Cilostazol	The serum concentration of Cilostazol can be increased when it is combined with Miconazole.	Approved
Cimetidine	The serum concentration of Cimetidine can be increased when it is combined with Miconazole.	Approved
Cinnarizine	The risk or severity of adverse effects can be increased when Miconazole is combined with Cinnarizine.	Approved
Ciprofloxacin	The serum concentration of Ciprofloxacin can be increased when it is combined with Miconazole.	Approved, Investigational
Cisapride	The serum concentration of Cisapride can be increased when it is combined with Miconazole.	Approved, Investigational, Withdrawn
Cisplatin	The serum concentration of Cisplatin can be increased when it is combined with Miconazole.	Approved
Citalopram	The serum concentration of Citalopram can be increased when it is combined with Miconazole.	Approved
Clarithromycin	The metabolism of Miconazole can be decreased when combined with Clarithromycin.	Approved
Clemastine	The metabolism of Miconazole can be decreased when combined with Clemastine.	Approved
Clevidipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Clevidipine.	Approved
Clobazam	The serum concentration of Clobazam can be increased when it is combined with Miconazole.	Approved, Illicit
Clomifene	The serum concentration of Clomifene can be increased when it is combined with Miconazole.	Approved, Investigational
Clonidine	The serum concentration of Clonidine can be increased when it is combined with Miconazole.	Approved
Clopidogrel	The serum concentration of Clopidogrel can be increased when it is combined with Miconazole.	Approved, Nutraceutical
Clotrimazole	The metabolism of Miconazole can be decreased when combined with Clotrimazole.	Approved, Vet Approved
Clozapine	The serum concentration of Clozapine can be increased when it is combined with Miconazole.	Approved
Cobicistat	The metabolism of Miconazole can be decreased when combined with Cobicistat.	Approved
Cobimetinib	The serum concentration of Cobimetinib can be increased when it is combined with Miconazole.	Approved
Colchicine	The serum concentration of Colchicine can be increased when it is combined with Miconazole.	Approved
Conivaptan	The metabolism of Conivaptan can be decreased when combined with Miconazole.	Approved, Investigational
Conjugated estrogens	The serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Miconazole.	Approved
Crizotinib	The metabolism of Miconazole can be decreased when combined with Crizotinib.	Approved
Cyclosporine	The metabolism of Cyclosporine can be decreased when combined with Miconazole.	Approved, Investigational, Vet Approved
Dabigatran etexilate	The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Miconazole.	Approved
Dabrafenib	The serum concentration of Miconazole can be decreased when it is combined with Dabrafenib.	Approved
Dactinomycin	The serum concentration of Dactinomycin can be increased when it is combined with Miconazole.	Approved
Dapagliflozin	The serum concentration of Dapagliflozin can be increased when it is combined with Miconazole.	Approved
Darodipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Darodipine.	Experimental
Darunavir	The metabolism of Miconazole can be decreased when combined with Darunavir.	Approved
Dasatinib	The serum concentration of Miconazole can be increased when it is combined with Dasatinib.	Approved, Investigational
Daunorubicin	The serum concentration of Daunorubicin can be increased when it is combined with Miconazole.	Approved
Debrisoquin	The serum concentration of Debrisoquin can be increased when it is combined with Miconazole.	Approved
Deferasirox	The serum concentration of Miconazole can be decreased when it is combined with Deferasirox.	Approved, Investigational
Delavirdine	The metabolism of Miconazole can be decreased when combined with Delavirdine.	Approved
Dexamethasone	The serum concentration of Miconazole can be decreased when it is combined with Dexamethasone.	Approved, Investigational, Vet Approved
Diazepam	The serum concentration of Diazepam can be increased when it is combined with Miconazole.	Approved, Illicit, Vet Approved
Dicoumarol	The serum concentration of Dicoumarol can be increased when it is combined with Miconazole.	Approved
Didanosine	Didanosine can cause a decrease in the absorption of Miconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved
Diethylstilbestrol	The serum concentration of Diethylstilbestrol can be increased when it is combined with Miconazole.	Approved
Digitoxin	The serum concentration of Digitoxin can be increased when it is combined with Miconazole.	Approved
Digoxin	The serum concentration of Digoxin can be increased when it is combined with Miconazole.	Approved
Dihydroergotamine	The metabolism of Miconazole can be decreased when combined with Dihydroergotamine.	Approved
Dihydrotestosterone	The serum concentration of Dihydrotestosterone can be increased when it is combined with Miconazole.	Illicit
Diltiazem	The risk or severity of adverse effects can be increased when Miconazole is combined with Diltiazem.	Approved
Dipyridamole	The serum concentration of Dipyridamole can be increased when it is combined with Miconazole.	Approved
Docetaxel	The metabolism of Docetaxel can be decreased when combined with Miconazole.	Approved, Investigational
Dofetilide	The metabolism of Dofetilide can be decreased when combined with Miconazole.	Approved
Domperidone	The serum concentration of Domperidone can be increased when it is combined with Miconazole.	Approved, Investigational, Vet Approved
Doxorubicin	The serum concentration of Doxorubicin can be increased when it is combined with Miconazole.	Approved, Investigational
Doxycycline	The metabolism of Miconazole can be decreased when combined with Doxycycline.	Approved, Investigational, Vet Approved
Dronedarone	The metabolism of Miconazole can be decreased when combined with Dronedarone.	Approved
Edoxaban	The serum concentration of Edoxaban can be increased when it is combined with Miconazole.	Approved
Efavirenz	The serum concentration of Miconazole can be decreased when it is combined with Efavirenz.	Approved, Investigational
Efonidipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Efonidipine.	Approved
Eletriptan	The serum concentration of Eletriptan can be increased when it is combined with Miconazole.	Approved, Investigational
Enzalutamide	The serum concentration of Miconazole can be decreased when it is combined with Enzalutamide.	Approved
Eperisone	The risk or severity of adverse effects can be increased when Miconazole is combined with Eperisone.	Approved, Investigational
Epinastine	The serum concentration of Epinastine can be increased when it is combined with Miconazole.	Approved, Investigational
Erlotinib	The serum concentration of Erlotinib can be increased when it is combined with Miconazole.	Approved, Investigational
Erythromycin	The metabolism of Miconazole can be decreased when combined with Erythromycin.	Approved, Vet Approved
Eslicarbazepine acetate	The serum concentration of Miconazole can be decreased when it is combined with Eslicarbazepine acetate.	Approved
Estradiol	The serum concentration of Estradiol can be increased when it is combined with Miconazole.	Approved, Investigational, Vet Approved
Estriol	The serum concentration of Estriol can be increased when it is combined with Miconazole.	Approved, Vet Approved
Estrone	The serum concentration of Estrone can be increased when it is combined with Miconazole.	Approved
Ethinyl Estradiol	The serum concentration of Ethinyl Estradiol can be increased when it is combined with Miconazole.	Approved
Ethyl biscoumacetate	The serum concentration of Ethyl biscoumacetate can be increased when it is combined with Miconazole.	Withdrawn
Etoposide	The serum concentration of Etoposide can be increased when it is combined with Miconazole.	Approved
Etravirine	The serum concentration of Etravirine can be increased when it is combined with Miconazole.	Approved
Everolimus	The serum concentration of Everolimus can be increased when it is combined with Miconazole.	Approved
Ezetimibe	The serum concentration of Ezetimibe can be increased when it is combined with Miconazole.	Approved
Felodipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Felodipine.	Approved, Investigational
Fendiline	The risk or severity of adverse effects can be increased when Miconazole is combined with Fendiline.	Withdrawn
Fesoterodine	The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Miconazole.	Approved
Fexofenadine	The serum concentration of Fexofenadine can be increased when it is combined with Miconazole.	Approved
Fidaxomicin	The serum concentration of Fidaxomicin can be increased when it is combined with Miconazole.	Approved
Fluconazole	The metabolism of Miconazole can be decreased when combined with Fluconazole.	Approved
Flunarizine	The risk or severity of adverse effects can be increased when Miconazole is combined with Flunarizine.	Approved
Fluticasone furoate	The serum concentration of Fluticasone furoate can be increased when it is combined with Miconazole.	Approved
Fluvoxamine	The metabolism of Miconazole can be decreased when combined with Fluvoxamine.	Approved, Investigational
Fosamprenavir	The metabolism of Miconazole can be decreased when combined with Fosamprenavir.	Approved
Fosaprepitant	The serum concentration of Miconazole can be increased when it is combined with Fosaprepitant.	Approved
Fosphenytoin	The serum concentration of Miconazole can be decreased when it is combined with Fosphenytoin.	Approved
Fosphenytoin	The serum concentration of Fosphenytoin can be increased when it is combined with Miconazole.	Approved
Fusidic Acid	The serum concentration of Miconazole can be increased when it is combined with Fusidic Acid.	Approved
Gabapentin	The risk or severity of adverse effects can be increased when Miconazole is combined with Gabapentin.	Approved, Investigational
Gefitinib	The serum concentration of Gefitinib can be increased when it is combined with Miconazole.	Approved, Investigational
Gemcitabine	The serum concentration of Gemcitabine can be increased when it is combined with Miconazole.	Approved
Glibornuride	Miconazole may increase the hypoglycemic activities of Glibornuride.	Withdrawn
Gliclazide	Miconazole may increase the hypoglycemic activities of Gliclazide.	Approved
Glimepiride	Miconazole may increase the hypoglycemic activities of Glimepiride.	Approved
Glipizide	Miconazole may increase the hypoglycemic activities of Glipizide.	Approved
Gliquidone	Miconazole may increase the hypoglycemic activities of Gliquidone.	Approved
Glisoxepide	Miconazole may increase the hypoglycemic activities of Glisoxepide.	Approved
Glyburide	Miconazole may increase the hypoglycemic activities of Glyburide.	Approved
Grazoprevir	The serum concentration of Grazoprevir can be increased when it is combined with Miconazole.	Approved
Grepafloxacin	The serum concentration of Grepafloxacin can be increased when it is combined with Miconazole.	Withdrawn
Haloperidol	The serum concentration of Haloperidol can be increased when it is combined with Miconazole.	Approved
Hydrocortisone	The serum concentration of Hydrocortisone can be increased when it is combined with Miconazole.	Approved, Vet Approved
Ibuprofen	The serum concentration of Ibuprofen can be increased when it is combined with Miconazole.	Approved
Idelalisib	The serum concentration of Miconazole can be increased when it is combined with Idelalisib.	Approved
Imatinib	The metabolism of Miconazole can be decreased when combined with Imatinib.	Approved
Imipramine	The serum concentration of Imipramine can be increased when it is combined with Miconazole.	Approved
Indacaterol	The serum concentration of Indacaterol can be increased when it is combined with Miconazole.	Approved
Indinavir	The metabolism of Miconazole can be decreased when combined with Indinavir.	Approved
Indomethacin	The serum concentration of Indomethacin can be increased when it is combined with Miconazole.	Approved, Investigational
Irinotecan	The serum concentration of Irinotecan can be increased when it is combined with Miconazole.	Approved, Investigational
Isavuconazonium	The metabolism of Miconazole can be decreased when combined with Isavuconazonium.	Approved, Investigational
Isradipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Isradipine.	Approved
Itraconazole	The metabolism of Miconazole can be decreased when combined with Itraconazole.	Approved, Investigational
Ivacaftor	The serum concentration of Miconazole can be increased when it is combined with Ivacaftor.	Approved
Ivermectin	The serum concentration of Ivermectin can be increased when it is combined with Miconazole.	Approved, Vet Approved
Ketazolam	The serum concentration of Ketazolam can be increased when it is combined with Miconazole.	Approved
Ketoconazole	The metabolism of Miconazole can be decreased when combined with Ketoconazole.	Approved, Investigational
Lacidipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Lacidipine.	Approved
Lamivudine	The serum concentration of Lamivudine can be increased when it is combined with Miconazole.	Approved, Investigational
Lamotrigine	The risk or severity of adverse effects can be increased when Miconazole is combined with Lamotrigine.	Approved, Investigational
Lansoprazole	The serum concentration of Lansoprazole can be increased when it is combined with Miconazole.	Approved, Investigational
Ledipasvir	The serum concentration of Ledipasvir can be increased when it is combined with Miconazole.	Approved
Lenalidomide	The serum concentration of Lenalidomide can be increased when it is combined with Miconazole.	Approved
Lenvatinib	The serum concentration of Lenvatinib can be increased when it is combined with Miconazole.	Approved
Lercanidipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Lercanidipine.	Approved, Investigational
Levetiracetam	The serum concentration of Levetiracetam can be increased when it is combined with Miconazole.	Approved, Investigational
Levofloxacin	The serum concentration of Levofloxacin can be increased when it is combined with Miconazole.	Approved, Investigational
Levomilnacipran	The serum concentration of Levomilnacipran can be increased when it is combined with Miconazole.	Approved
Linagliptin	The serum concentration of Linagliptin can be increased when it is combined with Miconazole.	Approved
Loperamide	The serum concentration of Loperamide can be increased when it is combined with Miconazole.	Approved
Lopinavir	The metabolism of Miconazole can be decreased when combined with Lopinavir.	Approved
Losartan	The metabolism of Losartan can be decreased when combined with Miconazole.	Approved
Lovastatin	The metabolism of Miconazole can be decreased when combined with Lovastatin.	Approved, Investigational
Luliconazole	The serum concentration of Miconazole can be increased when it is combined with Luliconazole.	Approved
Lumacaftor	The metabolism of Miconazole can be increased when combined with Lumacaftor.	Approved
Magnesium Sulfate	The risk or severity of adverse effects can be increased when Miconazole is combined with Magnesium Sulfate.	Approved, Vet Approved
Manidipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Manidipine.	Approved
Mannitol	The serum concentration of Mannitol can be increased when it is combined with Miconazole.	Approved, Investigational
Methotrexate	The serum concentration of Methotrexate can be increased when it is combined with Miconazole.	Approved
Methylprednisolone	The serum concentration of Methylprednisolone can be increased when it is combined with Miconazole.	Approved, Vet Approved
Metoprolol	The serum concentration of Metoprolol can be increased when it is combined with Miconazole.	Approved, Investigational
Mibefradil	The risk or severity of adverse effects can be increased when Miconazole is combined with Mibefradil.	Withdrawn
Midazolam	The serum concentration of Midazolam can be increased when it is combined with Miconazole.	Approved, Illicit
Mifepristone	The serum concentration of Miconazole can be increased when it is combined with Mifepristone.	Approved, Investigational
Mirabegron	The serum concentration of Mirabegron can be increased when it is combined with Miconazole.	Approved
Mitotane	The serum concentration of Miconazole can be decreased when it is combined with Mitotane.	Approved
Mitoxantrone	The serum concentration of Mitoxantrone can be increased when it is combined with Miconazole.	Approved, Investigational
Modafinil	The serum concentration of Miconazole can be decreased when it is combined with Modafinil.	Approved, Investigational
Morphine	The serum concentration of Morphine can be increased when it is combined with Miconazole.	Approved, Investigational
Mycophenolate mofetil	The serum concentration of Mycophenolate mofetil can be increased when it is combined with Miconazole.	Approved, Investigational
Nadolol	The serum concentration of Nadolol can be increased when it is combined with Miconazole.	Approved
Nafcillin	The serum concentration of Miconazole can be decreased when it is combined with Nafcillin.	Approved
Naloxegol	The serum concentration of Naloxegol can be increased when it is combined with Miconazole.	Approved
Naloxone	The serum concentration of Naloxone can be increased when it is combined with Miconazole.	Approved, Vet Approved
Nefazodone	The metabolism of Miconazole can be decreased when combined with Nefazodone.	Approved, Withdrawn
Nelfinavir	The metabolism of Miconazole can be decreased when combined with Nelfinavir.	Approved
Netupitant	The serum concentration of Miconazole can be increased when it is combined with Netupitant.	Approved
Nevirapine	The metabolism of Miconazole can be increased when combined with Nevirapine.	Approved
Nicardipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Nicardipine.	Approved
Nifedipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Nifedipine.	Approved
Niguldipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Niguldipine.	Experimental
Nilotinib	The metabolism of Miconazole can be decreased when combined with Nilotinib.	Approved, Investigational
Niludipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Niludipine.	Experimental
Nilvadipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Nilvadipine.	Approved
Nimesulide	The risk or severity of adverse effects can be increased when Miconazole is combined with Nimesulide.	Approved, Withdrawn
Nimodipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Nimodipine.	Approved
Nintedanib	The serum concentration of Nintedanib can be increased when it is combined with Miconazole.	Approved
Nisoldipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Nisoldipine.	Approved
Nitrendipine	The risk or severity of adverse effects can be increased when Miconazole is combined with Nitrendipine.	Approved
Nizatidine	The serum concentration of Nizatidine can be increased when it is combined with Miconazole.	Approved
Olanzapine	The serum concentration of Olanzapine can be increased when it is combined with Miconazole.	Approved, Investigational
Olaparib	The metabolism of Miconazole can be decreased when combined with Olaparib.	Approved
Ombitasvir	The serum concentration of Ombitasvir can be increased when it is combined with Miconazole.	Approved
Osimertinib	The serum concentration of Miconazole can be increased when it is combined with Osimertinib.	Approved
Paclitaxel	The serum concentration of Paclitaxel can be increased when it is combined with Miconazole.	Approved, Vet Approved
Palbociclib	The serum concentration of Miconazole can be increased when it is combined with Palbociclib.	Approved
Panobinostat	The serum concentration of Panobinostat can be increased when it is combined with Miconazole.	Approved, Investigational
Pazopanib	The serum concentration of Pazopanib can be increased when it is combined with Miconazole.	Approved
Pentobarbital	The metabolism of Miconazole can be increased when combined with Pentobarbital.	Approved, Vet Approved
Perhexiline	The risk or severity of adverse effects can be increased when Miconazole is combined with Perhexiline.	Approved
Phenindione	The serum concentration of Phenindione can be increased when it is combined with Miconazole.	Approved
Phenobarbital	The metabolism of Miconazole can be increased when combined with Phenobarbital.	Approved
Phenprocoumon	The serum concentration of Phenprocoumon can be increased when it is combined with Miconazole.	Approved
Phenytoin	The serum concentration of Phenytoin can be increased when it is combined with Miconazole.	Approved, Vet Approved
Pimozide	Miconazole may increase the arrhythmogenic activities of Pimozide.	Approved
Pinaverium	The risk or severity of adverse effects can be increased when Miconazole is combined with Pinaverium.	Approved
Pitavastatin	The serum concentration of Pitavastatin can be increased when it is combined with Miconazole.	Approved
Pomalidomide	The serum concentration of Pomalidomide can be increased when it is combined with Miconazole.	Approved
Ponatinib	The serum concentration of Ponatinib can be increased when it is combined with Miconazole.	Approved
Posaconazole	The metabolism of Miconazole can be decreased when combined with Posaconazole.	Approved, Investigational, Vet Approved
Pravastatin	The serum concentration of Pravastatin can be increased when it is combined with Miconazole.	Approved
Prazosin	The serum concentration of Prazosin can be increased when it is combined with Miconazole.	Approved
Prednisolone	The serum concentration of Prednisolone can be increased when it is combined with Miconazole.	Approved, Vet Approved
Prednisone	The serum concentration of Prednisone can be increased when it is combined with Miconazole.	Approved, Vet Approved
Pregabalin	The risk or severity of adverse effects can be increased when Miconazole is combined with Pregabalin.	Approved, Illicit, Investigational
Prenylamine	The risk or severity of adverse effects can be increased when Miconazole is combined with Prenylamine.	Withdrawn
Primidone	The metabolism of Miconazole can be increased when combined with Primidone.	Approved, Vet Approved
Progesterone	The therapeutic efficacy of Progesterone can be decreased when used in combination with Miconazole.	Approved, Vet Approved
Propranolol	The serum concentration of Propranolol can be increased when it is combined with Miconazole.	Approved, Investigational
Prucalopride	The serum concentration of Prucalopride can be increased when it is combined with Miconazole.	Approved
Quetiapine	The serum concentration of Quetiapine can be increased when it is combined with Miconazole.	Approved
Quinidine	The metabolism of Quinidine can be decreased when combined with Miconazole.	Approved
Quinine	The serum concentration of Quinine can be increased when it is combined with Miconazole.	Approved
Ranitidine	The serum concentration of Ranitidine can be increased when it is combined with Miconazole.	Approved
Ranolazine	The metabolism of Ranolazine can be decreased when combined with Miconazole.	Approved, Investigational
Reserpine	The serum concentration of Reserpine can be increased when it is combined with Miconazole.	Approved
Rifabutin	The metabolism of Miconazole can be increased when combined with Rifabutin.	Approved
Rifampicin	The metabolism of Miconazole can be increased when combined with Rifampicin.	Approved
Rifapentine	The metabolism of Miconazole can be increased when combined with Rifapentine.	Approved
Rifaximin	The serum concentration of Rifaximin can be increased when it is combined with Miconazole.	Approved, Investigational
Risedronate	The risk or severity of adverse effects can be increased when Miconazole is combined with Risedronate.	Approved, Investigational
Risperidone	The serum concentration of Risperidone can be increased when it is combined with Miconazole.	Approved, Investigational
Ritonavir	The metabolism of Miconazole can be decreased when combined with Ritonavir.	Approved, Investigational
Rivaroxaban	The serum concentration of Rivaroxaban can be increased when it is combined with Miconazole.	Approved
Romidepsin	The serum concentration of Romidepsin can be increased when it is combined with Miconazole.	Approved, Investigational
Salicylic acid	The serum concentration of Salicylic acid can be increased when it is combined with Miconazole.	Approved, Vet Approved
Saquinavir	The metabolism of Miconazole can be decreased when combined with Saquinavir.	Approved, Investigational
Selexipag	The serum concentration of Selexipag can be increased when it is combined with Miconazole.	Approved
Sildenafil	The metabolism of Miconazole can be decreased when combined with Sildenafil.	Approved, Investigational
Silodosin	The serum concentration of Silodosin can be increased when it is combined with Miconazole.	Approved
Siltuximab	The serum concentration of Miconazole can be decreased when it is combined with Siltuximab.	Approved
Simeprevir	The serum concentration of Miconazole can be increased when it is combined with Simeprevir.	Approved
Sitagliptin	The serum concentration of Sitagliptin can be increased when it is combined with Miconazole.	Approved, Investigational
Sofosbuvir	The serum concentration of Sofosbuvir can be increased when it is combined with Miconazole.	Approved
Solifenacin	The metabolism of Solifenacin can be decreased when combined with Miconazole.	Approved
Sorafenib	The serum concentration of Sorafenib can be increased when it is combined with Miconazole.	Approved, Investigational
Sparfloxacin	The serum concentration of Sparfloxacin can be increased when it is combined with Miconazole.	Approved
Sphingosine	The serum concentration of Sphingosine can be increased when it is combined with Miconazole.	Experimental
St. John's Wort	The serum concentration of Miconazole can be decreased when it is combined with St. John's Wort.	Nutraceutical
Stiripentol	The serum concentration of Miconazole can be increased when it is combined with Stiripentol.	Approved
Sucralfate	Sucralfate can cause a decrease in the absorption of Miconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved
Sulfisoxazole	The metabolism of Miconazole can be decreased when combined with Sulfisoxazole.	Approved, Vet Approved
Sunitinib	The metabolism of Sunitinib can be decreased when combined with Miconazole.	Approved, Investigational
Tacrolimus	The metabolism of Tacrolimus can be decreased when combined with Miconazole.	Approved, Investigational
Tacrolimus	The serum concentration of Tacrolimus can be increased when it is combined with Miconazole.	Approved, Investigational
Tamoxifen	The serum concentration of Tamoxifen can be increased when it is combined with Miconazole.	Approved
Taurocholic Acid	The serum concentration of Taurocholic Acid can be increased when it is combined with Miconazole.	Experimental
Technetium Tc-99m sestamibi	The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Miconazole.	Approved
Telaprevir	The metabolism of Miconazole can be decreased when combined with Telaprevir.	Withdrawn
Telithromycin	The metabolism of Miconazole can be decreased when combined with Telithromycin.	Approved
Temsirolimus	The serum concentration of Temsirolimus can be increased when it is combined with Miconazole.	Approved
Thioridazine	The serum concentration of Thioridazine can be increased when it is combined with Miconazole.	Withdrawn
Ticagrelor	The serum concentration of Ticagrelor can be increased when it is combined with Miconazole.	Approved
Ticlopidine	The metabolism of Miconazole can be decreased when combined with Ticlopidine.	Approved
Timolol	The serum concentration of Timolol can be increased when it is combined with Miconazole.	Approved
Tocilizumab	The serum concentration of Miconazole can be decreased when it is combined with Tocilizumab.	Approved
Tolazamide	Miconazole may increase the hypoglycemic activities of Tolazamide.	Approved
Tolbutamide	Miconazole may increase the hypoglycemic activities of Tolbutamide.	Approved
Tolfenamic Acid	The risk or severity of adverse effects can be increased when Miconazole is combined with Tolfenamic Acid.	Approved
Tolvaptan	The serum concentration of Tolvaptan can be increased when it is combined with Miconazole.	Approved
Topotecan	The serum concentration of Topotecan can be increased when it is combined with Miconazole.	Approved, Investigational
Toremifene	The serum concentration of Toremifene can be increased when it is combined with Miconazole.	Approved, Investigational
Tranilast	The risk or severity of adverse effects can be increased when Miconazole is combined with Tranilast.	Approved, Investigational
Trastuzumab emtansine	The serum concentration of Trastuzumab emtansine can be increased when it is combined with Miconazole.	Approved
Ulipristal	The serum concentration of Ulipristal can be increased when it is combined with Miconazole.	Approved
Umeclidinium	The serum concentration of Umeclidinium can be increased when it is combined with Miconazole.	Approved
Vecuronium	The serum concentration of Vecuronium can be increased when it is combined with Miconazole.	Approved
Venetoclax	The serum concentration of Venetoclax can be increased when it is combined with Miconazole.	Approved
Venlafaxine	The metabolism of Miconazole can be decreased when combined with Venlafaxine.	Approved
Verapamil	The risk or severity of adverse effects can be increased when Miconazole is combined with Verapamil.	Approved
Vinblastine	The serum concentration of Vinblastine can be increased when it is combined with Miconazole.	Approved
Vincristine	The serum concentration of Vincristine can be increased when it is combined with Miconazole.	Approved, Investigational
Vismodegib	The serum concentration of Vismodegib can be increased when it is combined with Miconazole.	Approved
Voriconazole	The metabolism of Miconazole can be decreased when combined with Voriconazole.	Approved, Investigational
Warfarin	The serum concentration of Warfarin can be increased when it is combined with Miconazole.	Approved
Xylometazoline	The risk or severity of adverse effects can be increased when Miconazole is combined with Xylometazoline.	Approved
Ziconotide	The risk or severity of adverse effects can be increased when Miconazole is combined with Ziconotide.	Approved
Zidovudine	The serum concentration of Zidovudine can be increased when it is combined with Miconazole.	Approved
Ziprasidone	The metabolism of Miconazole can be decreased when combined with Ziprasidone.	Approved
Zolpidem	The serum concentration of Zolpidem can be increased when it is combined with Miconazole.	Approved

Food Interactions

Not Available

References

Synthesis Reference

"DrugSyn.org":http://www.drugsyn.org/Miconazole.htm

US3717655

General References

Not Available

External Links

Resource	Link
Human Metabolome Database (HMDB)	HMDB15242
KEGG Drug	D00882
KEGG Compound	C08070
PubChem Compound	4189
PubChem Substance	46506017
ChemSpider	4044
BindingDB	31772
ChEBI	82892
ChEMBL	CHEMBL91
Therapeutic Targets Database	DAP000154
PharmGKB	PA450494
IUPHAR	2449
Guide to Pharmacology	2449
Drug Product Database	2373
RxList	http://www.rxlist.com/cgi/generic2/micon.htm
Drugs.com	http://www.drugs.com/cdi/miconazole-cream.html
PDRhealth	http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/mon1273.shtml
Wikipedia	Miconazole

ATC Codes

A01AB09

D01AC02

J02AB01

A07AC01

S02AA13

G01AF04

D01AC52

AHFS Codes

84:04.08.08

PDB Entries

Not Available

FDA label

Download (650 KB)

MSDS

Download (73.7 KB)

Clinical Trials

Phase	Status	Purpose	Conditions	Count
0	Completed	Treatment	Intertrigo	1
1	Completed	Diagnostic	Endometriosis	1
1	Completed	Prevention	HIV Disease	1
1	Completed	Treatment	Autoimmune Diseases / Disseminated or Multiple Sclerosis Nos / Disseminated Sclerosis / Multiple Sclerosis, Acute Relapsing / Multiple Sclerosis, Chronic Progressive / Multiple Sclerosis, Primary Progressive	1
1	Completed	Treatment	Healthy Volunteers	1
2, 3	Not Yet Recruiting	Treatment	Infections, Fungal	1
2, 3	Not Yet Recruiting	Treatment	Candidiasis infection	1
3	Completed	Treatment	Oral Candidiasis / Stomatitis, Denture	1
4	Completed	Not Available	Health / Vulvovaginal Candidiasis	1
4	Completed	Treatment	Diaper Rash	1
4	Recruiting	Treatment	Bacterial Vaginosis (BV) / Candidiasis infection	1
4	Unknown Status	Treatment	Melasma	1
4	Unknown Status	Treatment	Onychomycosis	1
Not Available	Completed	Not Available	Bacterial Vaginosis (BV) / Trichomonal Vaginitis / Vaginal Candidiasis	1
Not Available	Completed	Basic Science	Healthy Volunteers	1
Not Available	No Longer Available	Not Available	Diabetes, Diabetes Mellitus Type 1	1
Not Available	Unknown Status	Treatment	Onychomycosis	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Actavis Group
Advanced Pharmaceutical Services Inc.
Barr Pharmaceuticals
CVS Pharmacy
Dispensing Solutions
Diversified Healthcare Services Inc.
Draxis Specialty Pharmaceuticals Inc.
Ivax Pharmaceuticals
Johnson & Johnson Healthcare
Kaiser Foundation Hospital
Medisca Inc.
Ortho Mcneil Janssen Pharmaceutical Inc.
Orthopedics Advanced Care
Par Pharmaceuticals
Perrigo Co.
Pharmacia Inc.
Pharmedix
Physicians Total Care Inc.
Prescript Pharmaceuticals
Schering-Plough Inc.
Southwood Pharmaceuticals

Dosage forms

Form	Route	Strength
Cream	Topical	2 g/1000g
Ointment	Topical	2.82 g/141g
Ointment	Topical	1.12 g/56g
Cream	Topical	2 mg/100mL
Powder	Topical	2 g/100mL
Spray	Topical	2 g/100g
Cream	Topical	.02 g/g
Spray	Topical	20 mg/g
Ointment	Topical	20 mg/g
Cream	Topical	.02 g/100g
Cream	Topical
Powder	Topical	2 g/100g
Cream	Topical	20 g/1000g
Kit
Tincture	Topical	20 mg/mL
Cream	Topical	20 mg/mL
Aerosol, spray	Topical	.2 g/10g
Cream	Topical	20 mg/g
Powder	Topical	1.42 g/71g
Aerosol, powder	Topical	20 mg/g
Liquid	Topical	2 g/100g
Cream	Topical	2 %
Aerosol	Topical	2 %
Kit	Topical; Vaginal
Kit	Vaginal
Suppository	Vaginal	400 mg
Cream	Vaginal	2 g/100g
Cream	Vaginal	2 mg/100g
Suppository	Vaginal	100 mg/1
Aerosol, powder	Topical	2.6 g/130g
Aerosol, spray	Topical	1.3 g/130g
Aerosol, spray	Topical	1.3 g/131g
Aerosol, spray	Topical	2.6 g/130g
Aerosol, spray	Topical	3 g/150g
Cream	Vaginal	20 mg/g
Spray	Topical	3 g/150g
Suppository	Vaginal	100 ug/1
Suppository	Vaginal	200 mg/1
Powder	Topical	20 mg/g
Cream	Topical	.3 g/14g
Cream	Vaginal	20 mg
Capsule; cream; kit	Oral; Topical
Suppository	Vaginal	1200 mg
Cream; insert	Topical; Vaginal
Cream	Vaginal	4 %
Insert	Vaginal	400 mg
Cream; suppository	Topical; Vaginal
Suppository	Vaginal	100 mg
Cream	Vaginal	2 %
Cream	Topical	200 mg/mg
Cream	Topical	.02 mL/mL
Tablet	Buccal	50 mg/1
Liquid	Topical
Cream	Topical	2 g/100g
Cream	Topical	20 mg/100g
Cream	Topical	.7 g/35g
Aerosol, powder	Topical	2.56 g/128g
Cream	Vaginal	40 mg/g
Ointment	Topical	2 g/100g
Kit
Liquid	Topical	.3 mg/15mL
Ointment	Topical
Powder	Topical	20.6 mg/g

Prices

Unit description	Cost	Unit
Vusion 0.25-15-81.35% Ointment 50 gm Tube	284.34USD	tube
Miconazole 3 3 200 mg Suppository Box	51.2USD	box
Monistat-Derm 2% Cream 28.35 gm Tube	41.99USD	tube
Monistat-Derm 2% Cream 15 gm Tube	32.0USD	tube
Monistat 1 combination pack	16.81USD	each
Monistat 7 combination pack	15.96USD	each
Miconazole Nitrate 2% Cream 28 gm Tube	12.99USD	tube
Miconazole powder	4.59USD	g
Monistat 1 6.5% ointment	3.6USD	g
Miconazole nitrate powder	3.55USD	g
Vusion ointment	3.17USD	g
Monistat-derm 2% cream	1.11USD	g
Miconazole nitrate 2% cream	0.19USD	g
CVS Pharmacy miconazole 7 cream	0.18USD	g
Miconazole 7 cream	0.15USD	g
Antifungal 2% cream	0.1USD	g
Micatin 2% aerosol spray	0.05USD	g
Lotrimin af 2% liquid spray	0.04USD	g

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US5514698	No	1994-03-21	2014-03-21	US
US6153635	No	2000-11-28	2020-11-28	US
US6916485	No	2002-09-11	2022-09-11	US
US7651698	No	2002-09-11	2022-09-11	US
US8147852	No	2008-03-30	2028-03-30	US
US8518442	No	2002-09-11	2022-09-11	US

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	159-163 °C	Not Available
water solubility	1g/100mL (20 °C)	Not Available
logP	6.1	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.000763 mg/mL	ALOGPS
logP	5.86	ALOGPS
logP	5.96	ChemAxon
logS	-5.7	ALOGPS
pKa (Strongest Basic)	6.77	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	27.05 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	103.07 m³·mol^-1	ChemAxon
Polarizability	39.54 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	+	0.9735
Blood Brain Barrier	+	0.9823
Caco-2 permeable	+	0.6096
P-glycoprotein substrate	Non-substrate	0.545
P-glycoprotein inhibitor I	Non-inhibitor	0.7958
P-glycoprotein inhibitor II	Inhibitor	0.8387
Renal organic cation transporter	Inhibitor	0.6806
CYP450 2C9 substrate	Non-substrate	0.8407
CYP450 2D6 substrate	Non-substrate	0.9116
CYP450 3A4 substrate	Non-substrate	0.7017
CYP450 1A2 substrate	Inhibitor	0.9472
CYP450 2C9 inhibitor	Inhibitor	0.939
CYP450 2D6 inhibitor	Inhibitor	0.9413
CYP450 2C19 inhibitor	Inhibitor	0.9591
CYP450 3A4 inhibitor	Inhibitor	0.8861
CYP450 inhibitory promiscuity	High CYP Inhibitory Promiscuity	0.9961
Ames test	Non AMES toxic	0.9133
Carcinogenicity	Non-carcinogens	0.853
Biodegradation	Not ready biodegradable	0.9933
Rat acute toxicity	2.8478 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.5
hERG inhibition (predictor II)	Inhibitor	0.8505

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum Type	Description	Splash Key
LC-MS/MS	LC-MS/MS Spectrum - , positive	splash10-02t9-0501900000-40f5928152d84e02deef	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - , positive	splash10-0bt9-2900000000-1921b08c2de7bbf0624d	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-0bt9-0900500000-1a5805da9606edbe7e9a	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available
MS	Mass Spectrum (Electron Ionization)	splash10-0bt9-4900000000-3f143064c2acde7e15a4	View in MoNA

Taxonomy

Description

This compound belongs to the class of organic compounds known as benzylethers. These are aromatic ethers with the general formula ROCR' (R = alkyl, aryl; R'=benzene).

Kingdom

Organic compounds

Super Class

Benzenoids

Class

Benzene and substituted derivatives

Sub Class

Benzylethers

Direct Parent

Benzylethers

Alternative Parents

Dichlorobenzenes / N-substituted imidazoles / Aryl chlorides / Heteroaromatic compounds / Dialkyl ethers / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds / Organochlorides / Hydrocarbon derivatives

Substituents

Benzylether / 1,3-dichlorobenzene / Chlorobenzene / Halobenzene / Aryl chloride / Aryl halide / N-substituted imidazole / Imidazole / Azole / Heteroaromatic compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

imidazoles, ether, dichlorobenzene (CHEBI:82892 ) / a small molecule (CPD-4501 )

Get DrugBank to go!

Structure for DB01110 (Miconazole)

Targets

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