You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameMiconazole
Accession NumberDB01110  (APRD01115)
TypeSmall Molecule
GroupsApproved, Investigational, Vet Approved
DescriptionAn imidazole antifungal agent that is used topically and by intravenous infusion. [PubChem]
Structure
Thumb
Synonyms
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
Daktarin iv
Miconazole
Monistat iv (tn)
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
OravigTablet50 mg/1BuccalPraelia Pharmaceuticals Inc2012-11-012015-12-29Us
OravigTablet50 mg/1BuccalMidatech Pharma Us, Inc.2010-04-16Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Miconazole NitrateSuppository200 mg/1VaginalActavis Pharma, Inc.2002-09-03Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
3m Cavilon AntifungalCream2 g/1000gTopical3 M Health Care2010-11-30Not applicableUs
7 Day VaginalCream2 g/100gTopicalCardinal Health2009-03-16Not applicableUs
Aloe Vesta AntifungalOintment20 mg/gTopicalConva Tec, Inc.1997-10-03Not applicableUs
Aloe Vesta Clear AntifungalOintment2 g/100gTopicalConvatec Inc.2013-12-20Not applicableUs
Aloe Vesta Clear Antifungal 141gOintment2.82 g/141gTopicalGuest Packaging Llc.2016-06-09Not applicableUs
Aloe Vesta Clear Antifungal 56gOintment1.12 g/56gTopicalGuest Packaging Llc.2016-06-09Not applicableUs
Anti-fungalCream.02 g/gTopicalUniversal Distribution Center LLC2015-04-15Not applicableUs
AntifungalCream20 mg/gTopicalActavis Pharma, Inc.2007-05-01Not applicableUs
AntifungalCream20 mg/gTopicalPSS World Medical, Inc.2012-09-05Not applicableUs
AntifungalCream20 mg/gTopicalPreferred Pharmaceuticals Inc.2016-08-25Not applicableUs
Antifungal Skin Care CvsKitProduct Quest Mfg.2016-04-14Not applicableUs
Athlet Foot Well At WalgreensPowder2 g/100mLTopicalWalgreens2015-04-15Not applicableUs
Athletes FootSpray2 g/100gTopicalWalgreen Company2005-06-09Not applicableUs
Athletes FootSpray2 g/100gTopicalWalgreen Company2005-06-09Not applicableUs
Athletes Foot SpraySpray2 g/100gTopicalCVS Pharmacy2006-03-02Not applicableUs
AzolenTincture20 mg/mLTopicalStratus Pharmaceuticals, Inc.2011-12-01Not applicableUs
Baza AntifungalCream20 mg/gTopicalColoplast Manufacturing US, LLC2009-06-15Not applicableUs
Bf-micozoCream20 mg/gTopicalBright Future Pharmaceuticals Factory2011-03-08Not applicableUs
Budpak Antifungal Miconazole NitrateCream.02 g/gTopicalBudpak Inc.2013-11-29Not applicableUs
Care One Miconazole 1KitAmerican Sales Company2010-11-19Not applicableUs
Care One Miconazole 3KitAmerican Sales Company2004-07-27Not applicableUs
Care One Miconazole 7Cream2 g/100gVaginalAmerican Sales Company1999-10-11Not applicableUs
Careone Miconazole 3KitAmerican Sales Company2016-10-17Not applicableUs
Careone Miconazole 3KitAmerican Sales Company2014-04-13Not applicableUs
Carrington AntifungalCream20 mg/gTopicalMedline Industries, Inc.2007-01-01Not applicableUs
Clearly ConfidentCream20 mg/gTopicalGaneden Biotech, Inc.2013-12-17Not applicableUs
ConazolSpray20 mg/gTopicalMarcas Usa Llc2014-06-25Not applicableUs
ConazolCream20 mg/gTopicalMarcas Usa Llc2014-08-01Not applicableUs
Critic Aid Clear AFOintment20 mg/gTopicalColoplast Manufacturing US, LLC2009-06-15Not applicableUs
DermagungalCream.02 g/100gTopicalDerma Rite Industries, Llc2005-12-12Not applicableUs
DesenexPowder2 g/100gTopicalNovartis Consumer Health, Inc.2009-08-03Not applicableUs
DG Health MiconazoleCream2 g/100gVaginalDolgencorp, LLC2010-01-17Not applicableUs
Dg Health Miconazole 3KitDolgencorp Inc2010-02-22Not applicableUs
Dynarex Antifungal PowderPowder20 mg/gTopicalDynarex Corporation2016-05-19Not applicableUs
Elta TrivaseCream20 g/1000gTopicalSwiss American Products2002-04-30Not applicableUs
Equaline Athletes FootSpray2 g/100gTopicalSupervalu Inc2004-09-11Not applicableUs
Equaline Miconazole 1KitSupervalu Inc2010-06-11Not applicableUs
Equaline Miconazole 1KitSupervalu Inc2010-06-11Not applicableUs
Equaline Miconazole 3KitSupervalu Inc2012-01-16Not applicableUs
Equaline Miconazole 3KitSupervalu Inc2006-03-16Not applicableUs
Equaline Miconazole 7Cream2 g/100gVaginalSupervalu Inc2004-11-10Not applicableUs
Equate Athletes FootSpray2 g/100gTopicalWal Mart Stores Inc2011-09-18Not applicableUs
Equate Miconazole 1KitWal Mart Stores Inc2013-08-12Not applicableUs
Equate Miconazole 1KitWal Mart Stores Inc2010-06-09Not applicableUs
Exchange Select Miconazole 1KitArmy & Air Force Exchange Service2016-03-25Not applicableUs
Family Wellness Miconazole 3KitFamily Dollar Services Inc2013-03-29Not applicableUs
Femmesil Creme Maximum StrengthCream2 g/100gTopicalAidance Skincare & Topical Solutions, LLC2012-09-07Not applicableUs
Femmesil Maximum StrengthOintment2 g/100gTopicalAidance Skincare & Topical Solutions, LLC2012-09-07Not applicableUs
Foot SilkaPowder2 g/100mLTopicalGenomma Lab2016-02-25Not applicableUs
Fungoid TinctureTincture20 mg/mLTopicalPedinol Pharmacal, Inc.1994-01-01Not applicableUs
Fungoid Tincture Treatment KitKitPedinol Pharmacal, Inc.1994-01-01Not applicableUs
Genrx Daily Defense AntifungalCream20 mg/mLTopicalPure Tek Corporation2013-01-08Not applicableUs
Genrx Daily Defense AntifungalPowder20 mg/gTopicalPure Tek Corporation2013-01-08Not applicableUs
Good Neighbor Pharmacy Miconazole 1KitAmerisource Bergen2010-06-11Not applicableUs
Good Neighbor Pharmacy Miconazole 3KitAmerisource Bergen2012-09-04Not applicableUs
Good Neighbor Pharmacy Miconazole 7Cream2 g/100gVaginalAmerisource Bergen1999-10-11Not applicableUs
Good Neighbor Pharmacy Miconazole NitrateKitAmerisource Bergen2000-05-02Not applicableUs
Good Sense Miconazole 1KitL. Perrigo Company2010-06-29Not applicableUs
Good Sense Miconazole 3KitL. Perrigo Company2007-04-02Not applicableUs
Good Sense Miconazole 3KitL Perrigo Company2000-02-25Not applicableUs
Good Sense Miconazole 7Cream2 g/100gVaginalL Perrigo Company1999-07-30Not applicableUs
Good Sense Miconazole 7Cream2 g/100gVaginalL. Perrigo Company2000-02-22Not applicableUs
Green TetterineOintment2 g/100gTopicalS.S.S. Company1994-07-31Not applicableUs
Harris Teeter Miconazole 3KitHarris Teeter, LLC2015-11-21Not applicableUs
Harris Teeter Miconazole 7Cream2 g/100gVaginalHarris Teeter, LLC2015-11-21Not applicableUs
Healthy Accents Miconazole 3KitDZA Brands LLC2008-04-01Not applicableUs
Healthy Accents Miconazole 7Cream2 g/100gVaginalDZA Brands LLC2008-03-03Not applicableUs
Healthy Accents Miconazole 7Cream2 g/100gVaginalDZA Brands LLC2014-12-03Not applicableUs
Hongo KillerAerosol, spray.2 g/10gTopicalEfficient Laboratories Inc2004-10-01Not applicableUs
Image Essentials Miconazole TreatmentKitKmart Corporation2015-02-24Not applicableUs
Image Essentials Miconazole TreatmentKitKmart Corporation2015-08-20Not applicableUs
Image Essentials Miconazole TreatmentKitKmart Corporation2015-02-04Not applicableUs
Image Essentials Miconazole TreatmentKitKmart Corporation2014-12-03Not applicableUs
Image Essentials Miconazole TreatmentKitKmart Corporation2015-08-20Not applicableUs
Kaiser Permanente Miconazole NitrateCream20 mg/gTopicalKAISER FOUNDATION HOSPITALS1991-10-01Not applicableUs
Kendall AntifungalCream2 g/100gTopicalCOVIDIEN INC.2011-04-14Not applicableUs
Lagicam AntifungalCream40 mg/gVaginalGenomma Lab Usa, Inc.2005-03-02Not applicableUs
Leader MedicatedPowder1.42 g/71gTopicalCardinal Health Inc.2010-10-31Not applicableUs
Leader MedicatedAerosol, spray2.6 g/130gTopicalCardinal Health Inc.2010-03-15Not applicableUs
Leader Miconazole 1KitCardinal Health2011-01-19Not applicableUs
Lotrimin AF AntifungalSpray20 mg/gTopicalBayer HealthCare LLC1993-09-01Not applicableUs
Lotrimin AntifungalPowder20 mg/gTopicalBayer Health Care Llc1993-09-01Not applicableUs
Lotrimin AntifungalAerosol, powder20 mg/gTopicalBayer Health Care Llc1993-09-01Not applicableUs
Lotrimin AntifungalAerosol, powder20 mg/gTopicalBayer Healthcare1993-09-01Not applicableUs
Lotrimin AntifungalAerosol, powder20 mg/gTopicalBayer HealthCare LLC1993-09-01Not applicableUs
Macerrx WebCream2 g/100gTopicalClinical Therapeutic Solutions2013-06-06Not applicableUs
MakesenseCream2 g/100gTopicalCherry Hill Sales Co2014-07-15Not applicableUs
Medicated Anti-fungal MiconazoleLiquid2 g/100gTopicalAmerican Spraytech, Llc2010-06-02Not applicableUs
Meijer Miconazole 3Cream40 mg/gVaginalMeijer Distribution Inc2005-03-02Not applicableUs
MicatinCream20 mg/gTopicalWell Spring Pharmaceutical Corporation2009-06-24Not applicableUs
Micatin Cream - 2%Cream2 %TopicalWellspring Pharmaceutical Canada Corp1974-12-31Not applicableCanada
Micatin Powder Spray - Unscented 2%Aerosol2 %TopicalWellspring Pharmaceutical Canada Corp1997-06-16Not applicableCanada
MiconazoleCream20 mg/gTopicalKinray, Inc.2013-03-21Not applicableUs
MiconazoleCream20 mg/gTopicalGalentic Pharma (India) Priva Te Limited2013-07-18Not applicableUs
MiconazoleCream2 g/100gTopicalChain Drug Consortium, LLC2009-05-15Not applicableUs
Miconazole 1KitKroger Company2013-07-23Not applicableUs
Miconazole 1KitRite Aid Corporation2010-06-16Not applicableUs
Miconazole 1KitCVS Pharmacy2010-06-08Not applicableUs
Miconazole 1KitMeijer Distribution Inc2010-06-09Not applicableUs
Miconazole 1KitWalgreen Company2010-06-10Not applicableUs
Miconazole 1KitMeijer Distribution Inc2010-06-11Not applicableUs
Miconazole 1KitWalgreen Company2010-06-08Not applicableUs
Miconazole 1KitWestern Family Foods Inc2011-07-11Not applicableUs
Miconazole 1KitH E B2010-06-07Not applicableUs
Miconazole 1KitHy Vee Inc2010-06-13Not applicableUs
Miconazole 1KitWalgreen Company2011-12-15Not applicableUs
Miconazole 1KitSafeway2010-08-30Not applicableUs
Miconazole 1KitKroger Company2010-06-08Not applicableUs
Miconazole 1KitH E B2010-06-07Not applicableUs
Miconazole 1KitHy Vee Inc2010-06-13Not applicableUs
Miconazole 1KitRite Aid Corporation2010-06-09Not applicableUs
Miconazole 1KitMeijer Distribution Inc2010-06-09Not applicableUs
Miconazole 1 Feminine CareKitRite Aid Corporation2010-06-09Not applicableUs
Miconazole 1 Yeast Infection ReliefKitCVS Pharmacy2010-06-08Not applicableUs
Miconazole 3KitWestern Family Foods Inc2005-01-21Not applicableUs
Miconazole 3KitWalgreen Company2004-07-19Not applicableUs
Miconazole 3KitKroger Company2000-02-23Not applicableUs
Miconazole 3KitCVS Pharmacy2014-02-28Not applicableUs
Miconazole 3Cream40 mg/gVaginalShopko Stores Operating Co., LLC2005-03-02Not applicableUs
Miconazole 3KitRite Aid Corporation2014-02-12Not applicableUs
Miconazole 3KitKroger Company2004-08-17Not applicableUs
Miconazole 3KitH E B2006-03-14Not applicableUs
Miconazole 3KitWalgreen Company2005-07-08Not applicableUs
Miconazole 3KitWalgreen Company2005-07-01Not applicableUs
Miconazole 3KitHy Vee Inc2009-07-01Not applicableUs
Miconazole 3KitMeijer Distribution Inc2016-10-12Not applicableUs
Miconazole 3KitRite Aid Corporation2006-08-18Not applicableUs
Miconazole 3KitMeijer Distribution Inc2000-02-04Not applicableUs
Miconazole 3KitWalgreen Company2006-09-06Not applicableUs
Miconazole 3 Combination PackKitChain Drug Consortium, LLC2003-09-11Not applicableUs
Miconazole 3 Combination PackKitWakefern Food Corporation2007-05-29Not applicableUs
Miconazole 3 Combination PackKitVaginalCardinal Health2001-02-02Not applicableUs
Miconazole 3 Combination PackKitVaginalMajor Pharmaceuticals2002-12-02Not applicableUs
Miconazole 3 Combination PackKitRite Aid2001-03-01Not applicableUs
Miconazole 3 Combination PackKitCVS Pharmacy2001-03-01Not applicableUs
Miconazole 3 Combination PackKitFred's Inc.2009-06-09Not applicableUs
Miconazole 3 Combination PackKitVaginalCardinal Health2002-12-02Not applicableUs
Miconazole 3 Combination PackKitWal Mart Stores, Inc.2007-06-11Not applicableUs
Miconazole 3 DayKitPublix Super Markets Inc2009-06-26Not applicableUs
Miconazole 3 Day Ovule Treatment 400mgSuppository400 mgVaginalVita Health Products Inc1996-12-31Not applicableCanada
Miconazole 7Suppository100 mg/1VaginalMc Kesson2011-12-09Not applicableUs
Miconazole 7Cream2 g/100gVaginalWestern Family Foods Inc2011-08-10Not applicableUs
Miconazole 7Cream2 g/100gVaginalMeijer Distribution Inc2000-02-04Not applicableUs
Miconazole 7Cream2 g/100gVaginalCVS Pharmacy2009-09-15Not applicableUs
Miconazole 7Cream2 g/100gVaginalRexall2010-07-01Not applicableUs
Miconazole 7Cream2 g/100gVaginalActavis Pharma, Inc.2011-09-16Not applicableUs
Miconazole 7Cream2 g/100gVaginalSafeway1999-09-08Not applicableUs
Miconazole 7Cream2 g/100gVaginalH E B2006-01-09Not applicableUs
Miconazole 7Cream2 g/100gVaginalWalgreen Company2000-12-01Not applicableUs
Miconazole 7Cream2 g/100gVaginalExchange Select2002-07-12Not applicableUs
Miconazole 7Cream2 g/100gVaginalHy Vee Inc2000-02-15Not applicableUs
Miconazole 7Suppository100 mg/1VaginalActavis Pharma, Inc.1993-11-19Not applicableUs
Miconazole 7Cream2 mg/100gVaginalShopko Stores Operating Co., LLC1997-01-13Not applicableUs
Miconazole 7Cream2 g/100gVaginalChain Drug Marketing Association Inc.2010-07-01Not applicableUs
Miconazole 7Cream2 g/100gVaginalFamily Dollar Services Inc.2006-06-06Not applicableUs
Miconazole 7Cream2 g/100gVaginalChain Drug Consortium, LLC2003-09-11Not applicableUs
Miconazole 7Cream20 mg/gVaginalPreferred Pharmaceuticals, Inc.2012-07-27Not applicableUs
Miconazole 7Cream2 g/100gVaginalKroger Company1999-04-28Not applicableUs
Miconazole 7Cream2 g/100gVaginalFred's Inc.2009-06-09Not applicableUs
Miconazole 7Cream2 g/100gVaginalRite Aid2001-03-01Not applicableUs
Miconazole 7Cream2 g/100gVaginalWal Mart Stores, Inc.2008-03-03Not applicableUs
Miconazole 7Cream2 g/100gVaginalKroger Company2002-07-15Not applicableUs
Miconazole 7Cream2 g/100gVaginalWestern Family Foods Inc1999-10-08Not applicableUs
Miconazole 7Cream2 g/100gVaginalMajor Pharmaceuticals2009-04-21Not applicableUs
Miconazole 7Cream2 g/100gVaginalCardinal Health (Leader)2014-05-31Not applicableUs
Miconazole 7Cream2 g/100gVaginalREMEDYREPACK INC.2016-10-06Not applicableUs
Miconazole 7Cream2 g/100gVaginalCVS Pharmacy1999-09-02Not applicableUs
Miconazole 7 - Crm Vag 2%Cream2 %VaginalTechnilab Pharma Inc.1996-11-042005-08-05Canada
Miconazole NitrateAerosol, spray3 g/150gTopicalMeijer Distribution Inc2012-04-13Not applicableUs
Miconazole NitrateSuppository100 ug/1VaginalRebel Distributors Corp1997-04-30Not applicableUs
Miconazole NitrateCream20 mg/gVaginalTaro Pharmaceuticals U.S.A., Inc.1997-01-13Not applicableUs
Miconazole NitrateCream20 mg/gVaginalPreferred Pharmaceuticals Inc.2016-02-01Not applicableUs
Miconazole NitrateAerosol, powder2.6 g/130gTopicalCVS Pharmacy2014-01-01Not applicableUs
Miconazole NitrateAerosol, spray3 g/150gTopicalCVS Pharmacy2014-01-01Not applicableUs
Miconazole NitrateAerosol, powder2.6 g/130gTopicalPremier Brands of America Inc.2013-01-01Not applicableUs
Miconazole NitrateCream20 mg/gTopicalPreferred Pharmaceuticals, Inc.2014-09-02Not applicableUs
Miconazole NitratePowder1.42 g/71gTopicalAmerisource Bergen Drug Corporation2012-01-10Not applicableUs
Miconazole NitratePowder1.42 g/71gTopicalHarmon Store Inc.2014-01-27Not applicableUs
Miconazole NitrateCream20 mg/gTopicalRebel Distributors Corp2003-09-01Not applicableUs
Miconazole NitrateCream40 mg/gVaginalTaro Pharmaceuticals U.S.A., Inc.2005-03-02Not applicableUs
Miconazole NitrateCream20 mg/gTopicalPhysicians Total Care, Inc.2012-03-20Not applicableUs
Miconazole NitrateSuppository100 ug/1VaginalG&W Laboratories, Inc.1997-04-30Not applicableUs
Miconazole NitratePowder1.42 g/71gTopicalCVS Pharmacy2014-01-01Not applicableUs
Miconazole NitrateCream20 mg/gVaginalRebel Distributors Corp2008-01-01Not applicableUs
Miconazole NitrateAerosol, spray2.6 g/130gTopicalTopco Associates LLC2012-01-03Not applicableUs
Miconazole NitrateCream20 mg/gTopicalQualitest Pharmaceuticals2003-09-012017-03-31Us
Miconazole NitrateAerosol, powder2.6 g/130gTopicalPremier Brands of America Inc.2013-01-01Not applicableUs
Miconazole NitrateAerosol, spray3 g/150gTopicalHarmon Store Inc.2012-01-17Not applicableUs
Miconazole NitrateAerosol, spray1.3 g/131gTopicalCVS Pharmacy2014-01-01Not applicableUs
Miconazole NitrateAerosol, powder2.6 g/130gTopicalWal Mart Stores, Inc.2014-02-25Not applicableUs
Miconazole NitratePowder1.42 g/71gTopicalPremier Brands of America Inc.2013-01-01Not applicableUs
Miconazole NitrateCream20 mg/gVaginalG&W Laboratories, Inc.1996-02-22Not applicableUs
Miconazole NitrateAerosol, spray1.3 g/131gTopicalDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2013-05-13Not applicableUs
Miconazole NitrateAerosol, spray3 g/150gTopicalChain Drug Consortium, LLC2010-01-05Not applicableUs
Miconazole NitrateCream20 mg/gTopicalTaro Pharmaceuticals U.S.A., Inc.1991-10-01Not applicableUs
Miconazole NitratePowder1.42 g/71gTopicalTopco Associates LLC2014-10-31Not applicableUs
Miconazole NitratePowder1.42 g/71gTopicalCVS Pharmacy2014-01-01Not applicableUs
Miconazole NitrateAerosol, spray3 g/150gTopicalPremier Brands of America Inc.2013-01-01Not applicableUs
Miconazole NitratePowder1.42 g/71gTopicalCVS Pharmacy2012-01-04Not applicableUs
Miconazole NitratePowder1.42 g/71gTopicalChain Drug Consortium, LLC2011-06-10Not applicableUs
Miconazole NitrateSpray3 g/150gTopicalWalgreens Company2010-05-18Not applicableUs
Miconazole NitrateCream20 mg/gVaginalCentral Texas Community Health Centers1996-02-22Not applicableUs
Miconazole Nitrate 2% Cream AntifungalCream2 g/100gTopicalTrifecta Pharmaceuticals Usa Llc2016-03-22Not applicableUs
Miconazole Nitrate Vaginal Cream 2%Cream2 %VaginalVita Health Products Inc2003-03-13Not applicableCanada
Miconazole Nitrate Vaginal Cream USP, 2%Cream2 %VaginalTaro Pharmaceuticals Inc1997-08-12Not applicableCanada
MiconoleCream20 mg/gTopicalOption Labs2013-10-15Not applicableUs
MicozoleCream2 %VaginalTaro Pharmaceuticals Inc1997-08-11Not applicableCanada
Micro-guard (af)Powder20 mg/gTopicalColoplast Manufacturing US, LLC2009-06-15Not applicableUs
Molecular AF Molecular CreamCream.3 g/14gTopicalRenu Laboratories, Inc.2015-03-31Not applicableUs
Monazole 7 - Crm 20mg/gCream20 mgVaginalTechnilab Pharma Inc.1997-01-212001-09-05Canada
Monistat 1 Combination PackKitInsight Pharmaceuticals2001-06-29Not applicableUs
Monistat 1 Combination PackKitInsight Pharmaceuticals2001-06-29Not applicableUs
Monistat 1 Combination Pack Triple ActionKitInsight Pharmaceuticals2001-06-29Not applicableUs
Monistat 1 Vaginal OvuleSuppository1200 mgVaginalInsight Pharmaceuticals LLC1999-02-26Not applicableCanada
Monistat 3 3-day Pre-filled ApplicatorsCream40 mg/gVaginalInsight Pharmaceuticals1998-03-30Not applicableUs
Monistat 3 Combination PackKitMc Neil Ppc, Inc.2009-12-102016-11-10Us
Monistat 3 Combination PackKitInsight Pharmaceuticals1996-04-16Not applicableUs
Monistat 3 Combination PackKitInsight Pharmaceuticals2009-12-10Not applicableUs
Monistat 3 Combination PackKitPhysicians Total Care, Inc.2012-03-27Not applicableUs
Monistat 3 Combination PackKitMc Neil Ppc, Inc.2009-12-102016-11-10Us
Monistat 3 Combination Pack 3 Ovule InsertsKitInsight Pharmaceuticals1996-04-16Not applicableUs
Monistat 3 Combination Pack Triple ActionKitInsight Pharmaceuticals1996-04-16Not applicableUs
Monistat 3 Vaginal CreamCream4 %VaginalInsight Pharmaceuticals LLC2001-10-10Not applicableCanada
Monistat 3 Vaginal OvulesInsert400 mgVaginalInsight Pharmaceuticals LLC1981-12-31Not applicableCanada
Monistat 7 7-day Disposable ApplicatorsCream20 mg/gVaginalInsight Pharmaceuticals2010-04-15Not applicableUs
Monistat 7 Combination Pack 7-day Pre-filled ApplicatorsKitMc Neil Ppc, Inc.2011-10-152016-10-13Us
Monistat 7 Combination Pack 7-day Pre-filled ApplicatorsKitInsight Pharmaceuticals1993-04-26Not applicableUs
Monistat 7 Combination Pack Triple ActionKitInsight Pharmaceuticals1993-04-26Not applicableUs
Monistat 7 Combination Pack Triple ActionKitMc Neil, Ppc, Inc.2010-04-102016-10-13Us
Monistat 7 Sup Vag 100mgSuppository100 mgVaginalMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1978-12-312005-07-22Canada
Monistat 7 Vaginal CreamCream2 %VaginalInsight Pharmaceuticals LLC1978-12-31Not applicableCanada
Monistat 7 With Reusable ApplicatorCream20 mg/gVaginalInsight Pharmaceuticals1993-04-26Not applicableUs
Monistat Derm CreamCream2 %TopicalInsight Pharmaceuticals LLC1980-12-31Not applicableCanada
Nail MdCream200 mg/mgTopicalOmg Medical Group, Llc2013-02-14Not applicableUs
Novana Antifungal Barrier With MiconazoleCream.02 mL/mLTopicalNovana Medical, Llc2012-04-04Not applicableUs
Premier Value Miconazole 3Cream40 mg/gVaginalChain Drug Consortium2005-03-02Not applicableUs
Previsense Antifungal Moisture Barrier With Protease TechnologyCream2 g/100gTopicalMolnlycke Health Care2016-04-01Not applicableUs
Quality Choice 3 Day VaginalCream40 mg/gVaginalChain Drug Marketing Association2005-03-02Not applicableUs
Remedy AntifungalPowder2 g/100gTopicalMedline Industries, Inc.2012-11-19Not applicableUs
Remedy AntifungalPowder2 g/100gTopicalMedline Industries, Inc.2012-11-19Not applicableUs
Remedy Antifungal Targeted TreatmentPowder20 mg/gTopicalMedline Industries, Inc.2007-01-01Not applicableUs
Remedy Antifungal With OlivamineCream2 g/100gTopicalMedline Industries, Inc.2007-01-01Not applicableUs
Remedy With PhytoplexOintment2 g/100gTopicalMedline Industries Inc.2016-04-11Not applicableUs
Remedy With Phytoplex Antifungal ClearOintment2 g/100gTopicalMedline Industries Inc.2011-08-012018-12-31Us
Rexall Miconazole 3KitDolgencorp Inc2010-12-14Not applicableUs
Secura Antifungal Extra ThickCream20 mg/gTopicalSmith & Nephew Medical Ltd2003-08-01Not applicableUs
Secura Antifungal Extra ThickCream20 mg/gTopicalSmith & Nephew, Inc.2003-08-012018-06-30Us
Secura Antifungal GreaselessCream20 mg/gTopicalSmith & Nephew Medical Ltd2003-08-01Not applicableUs
Secura Antifungal GreaselessCream20 mg/gTopicalSmith & Nephew, Inc.2003-08-012018-06-30Us
Selan AntifungalCream2 g/100gTopicalPj Noyes Co. Inc.2003-11-05Not applicableUs
Signature Care Athletes FootSpray2 g/100gTopicalSafeway2015-10-09Not applicableUs
Signature Care Miconazole 1KitSafeway2015-09-28Not applicableUs
Signature Care Miconazole 3KitSafeway2015-10-06Not applicableUs
Signature Care Miconazole 3KitSafeway2015-12-09Not applicableUs
Signature Care Miconazole 7Cream2 g/100gVaginalSafeway2015-11-03Not applicableUs
Skin Protector With Breathable BarrierCream2 g/100gTopicalDiversified Manufacturing Corp2016-05-04Not applicableUs
Smart Sense 3 Day TreatmentKitKmart Corporation2011-05-25Not applicableUs
Smart Sense 3 Day Treatment Vaginal AntifungalKitKmart Corporation2011-05-16Not applicableUs
Smart Sense 7 Day TreatmentCream2 g/100gVaginalKmart Corporation2011-02-10Not applicableUs
Smart Sense Miconazole 1KitKmart Corporation2016-08-18Not applicableUs
Smart Sense Miconazole 1KitKmart Corporation2010-06-16Not applicableUs
Smart Sense Miconazole 1KitKmart Corporation2016-08-17Not applicableUs
Smart Sense Miconazole 1KitKmart Corporation2010-06-15Not applicableUs
Smart Sense Miconazole 1KitKmart Corporation2010-06-15Not applicableUs
Smart Sense Miconazole 3KitKmart Corporation2016-08-18Not applicableUs
Smart Sense Miconazole 3KitKmart Corporation2016-06-29Not applicableUs
Smart Sense Miconazole 7Cream2 g/100gVaginalKmart Corporation2016-06-24Not applicableUs
Soothe and Cool TreatCream20 mg/100gTopicalMedline Industries, Inc.2007-01-01Not applicableUs
Sunmark AntifungalCream20 mg/gTopicalMc Kesson1991-10-01Not applicableUs
Sunmark Miconazole 3KitMc Kesson2004-07-20Not applicableUs
Sunmark Miconazole 3KitMc Kesson2003-09-05Not applicableUs
Sunmark Miconazole 3KitMc Kesson2003-09-05Not applicableUs
Sunmark Miconazole 7Cream2 g/100gVaginalMc Kesson2003-11-25Not applicableUs
Sunmark Miconazole 7Cream2 g/100gVaginalMc Kesson2003-07-31Not applicableUs
Terrasil Rapid-relief VaginalKitAidance Skincare & Topical Solutions, LLC2014-04-18Not applicableUs
Thera Antifungal BodyPowder20 mg/gTopicalMc Kesson Medical Surgical Inc.2011-09-01Not applicableUs
Tineacide AntifungalCream.7 g/35gTopicalBlaine Labs Inc.2013-06-01Not applicableUs
Ting Spray PowderAerosol, powder2.56 g/128gTopicalInsight Pharmaceuticals2009-07-16Not applicableUs
Topcare Miconazole 1KitTopco Associates LLC2010-06-15Not applicableUs
Topcare Miconazole 1KitTopco Associates LLC2010-06-17Not applicableUs
Topcare Miconazole 3 Combination PackKitTopco Associates LLC2000-05-10Not applicableUs
Topcare Miconazole 3 Combination PackKitTopco Associates LLC2004-11-17Not applicableUs
Topcare Miconazole 3 Yeast Infection ReliefCream40 mg/gVaginalTopco Associates LLC2005-03-02Not applicableUs
Topcare Miconazole 7Cream2 g/100gVaginalTopco Associates LLC2000-02-29Not applicableUs
Touchless Care AntifungalSpray2 g/100gTopicalCrawford Healthcare, Inc.2014-12-29Not applicableUs
Triple Paste-AFOintment2 g/100gTopicalSummers Laboratories Inc2013-10-30Not applicableUs
Up and Up Jock Itch ReliefSpray2 g/100gTopicalTarget Corporation2013-09-25Not applicableUs
Up and Up MiconazoleKitTarget Corporation2010-07-08Not applicableUs
Up and Up Miconazole 1KitTarget Corporation2010-09-03Not applicableUs
Up and Up Miconazole 3KitTarget Corporation2009-08-17Not applicableUs
Up and Up Miconazole 3KitTarget Corporation2009-08-12Not applicableUs
Up and Up Miconazole 7Cream2 g/100gVaginalTarget Corporation2009-08-26Not applicableUs
Vagistat-3KitNovartis Consumer Health, Inc.2000-02-25Not applicableUs
Vite20Liquid.3 mg/15mLTopicalBlaine Labs Inc.2016-04-01Not applicableUs
Welmedix Homecare Pro 2-IN-1 Antifungal and Skin ProtectantOintment2 g/100gTopicalThe Akshay Wellness Group, Inc.2013-04-012016-10-13Us
White TetterineOintment2 g/100gTopicalS.S.S. Company1995-02-28Not applicableUs
ZeasorbPowder20.6 mg/gTopicalStiefel Laboratories Inc2011-03-14Not applicableUs
ZeasorbPowder20.6 mg/gTopicalStiefel Laboratories Inc2011-03-14Not applicableUs
Zeasorb AFPowder20.6 mg/gTopicalPhysicians Total Care, Inc.2008-03-31Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
DaktarinNot Available
DecocortNot Available
Femizol-MNot Available
Gyno-DaktarinNot Available
MiconazexNot Available
MonistatNot Available
Monistat-DermNot Available
Zeasorb-AFNot Available
ZimycanNot Available
Brand mixtures
NameLabellerIngredients
DermasanaOmg Medical Group, Llc
Monicure ComboInsight Pharmaceuticals LLC
Monistat 1 Combination PackInsight Pharmaceuticals LLC
Monistat 3 Dual-pakInsight Pharmaceuticals LLC
Monistat 7 Dual-pakInsight Pharmaceuticals LLC
Rash Relief AntifungalTouchless Care Concepts LLC
VusionPrestium Pharma, Inc.
Salts
Name/CASStructureProperties
Miconazole nitrate
22832-87-7
Thumb
  • InChI Key: MCCACAIVAXEFAL-UHFFFAOYSA-N
  • Monoisotopic Mass: 476.9816668
  • Average Mass: 479.14
DBSALT001242
Categories
UNII7NNO0D7S5M
CAS number22916-47-8
WeightAverage: 416.129
Monoisotopic: 413.986023908
Chemical FormulaC18H14Cl4N2O
InChI KeyBYBLEWFAAKGYCD-UHFFFAOYSA-N
InChI
InChI=1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2
IUPAC Name
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
SMILES
ClC1=CC(Cl)=C(COC(CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=C1
Pharmacology
IndicationFor topical application in the treatment of tinea pedis (athlete’s foot), tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis (moniliasis), and in the treatment of tinea versicolor.
Structured Indications
PharmacodynamicsMiconazole is an anti-fungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). It is used either on the skin or in the vagina for fungal infections. Miconazole was approved by the FDA in 1974. Miconazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.
Mechanism of actionMiconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
TargetKindPharmacological actionActionsOrganismUniProt ID
Lanosterol 14-alpha demethylaseProteinyes
inhibitor
YeastP10613 details
Nitric oxide synthase, endothelialProteinunknown
inhibitor
HumanP29474 details
Nitric oxide synthase, inducibleProteinunknown
inhibitor
HumanP35228 details
Calcium-activated potassium channel subunit alpha-1Proteinunknown
inhibitor
HumanQ12791 details
Calcium-activated potassium channel subunit beta-1Proteinunknown
inhibitor
HumanQ16558 details
Calcium-activated potassium channel subunit beta-2Proteinunknown
inhibitor
HumanQ9Y691 details
Calcium-activated potassium channel subunit beta-3Proteinunknown
inhibitor
HumanQ9NPA1 details
Calcium-activated potassium channel subunit beta-4Proteinunknown
inhibitor
HumanQ86W47 details
Intermediate conductance calcium-activated potassium channel protein 4Proteinunknown
inhibitor
HumanO15554 details
Small conductance calcium-activated potassium channel protein 1Proteinunknown
inhibitor
HumanQ92952 details
Small conductance calcium-activated potassium channel protein 2Proteinunknown
inhibitor
HumanQ9H2S1 details
Small conductance calcium-activated potassium channel protein 3Proteinunknown
inhibitor
HumanQ9UGI6 details
Potassium voltage-gated channel subfamily H member 2Proteinunknown
inhibitor
HumanQ12809 details
Potassium voltage-gated channel subfamily H member 6Proteinunknown
inhibitor
HumanQ9H252 details
Potassium voltage-gated channel subfamily H member 7Proteinunknown
inhibitor
HumanQ9NS40 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityOral, mouse: LD50 = 3800 mg/kg; Oral, rat: LD50 = 3 gm/kg. Ingestion of the amounts of the components contained in a tube of cream are unlikely to produce overdosage and toxic effects.
Affected organisms
  • Fungi, yeast and protozoans
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Miconazole.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Miconazole.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Miconazole.Approved
AcetohexamideMiconazole may increase the hypoglycemic activities of Acetohexamide.Withdrawn
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Miconazole.Approved, Vet Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Miconazole.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Miconazole.Experimental
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Miconazole.Approved, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Miconazole.Approved, Investigational
AmiodaroneThe metabolism of Miconazole can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Miconazole.Approved
AmlodipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Amlodipine.Approved
Amphotericin BThe therapeutic efficacy of Amphotericin B can be decreased when used in combination with Miconazole.Approved, Investigational
AmrinoneThe risk or severity of adverse effects can be increased when Miconazole is combined with Amrinone.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Miconazole.Approved
AprepitantThe serum concentration of Miconazole can be increased when it is combined with Aprepitant.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Miconazole.Approved, Investigational
ArtesunateThe serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Miconazole resulting in a loss in efficacy.Approved
AtazanavirThe metabolism of Miconazole can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Miconazole.Approved
AtomoxetineThe metabolism of Miconazole can be decreased when combined with Atomoxetine.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Miconazole.Approved, Investigational
AzelnidipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Azelnidipine.Approved
AzimilideThe risk or severity of adverse effects can be increased when Miconazole is combined with Azimilide.Investigational
BarnidipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Barnidipine.Approved
BenidipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Benidipine.Approved
BepridilThe risk or severity of adverse effects can be increased when Miconazole is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Miconazole.Approved, Vet Approved
BexaroteneThe serum concentration of Miconazole can be decreased when it is combined with Bexarotene.Approved, Investigational
BoceprevirThe metabolism of Miconazole can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Miconazole can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Miconazole can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Miconazole.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Miconazole.Approved
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Miconazole.Approved, Investigational
BuspironeThe metabolism of Buspirone can be decreased when combined with Miconazole.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Miconazole.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Miconazole.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Miconazole.Approved
CaiThe risk or severity of adverse effects can be increased when Miconazole is combined with Cai.Investigational
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Miconazole.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Miconazole.Approved
CarbamazepineThe metabolism of Miconazole can be increased when combined with Carbamazepine.Approved, Investigational
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Miconazole.Approved
CeritinibThe serum concentration of Miconazole can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Miconazole.Withdrawn
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Miconazole.Approved, Vet Approved
ChlorpropamideMiconazole may increase the hypoglycemic activities of Chlorpropamide.Approved
CilnidipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Cilnidipine.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Miconazole.Approved
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Miconazole.Approved
CinnarizineThe risk or severity of adverse effects can be increased when Miconazole is combined with Cinnarizine.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Miconazole.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Miconazole.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Miconazole.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Miconazole.Approved
ClarithromycinThe metabolism of Miconazole can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Miconazole can be decreased when combined with Clemastine.Approved
ClevidipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Clevidipine.Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Miconazole.Approved, Illicit
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Miconazole.Approved, Investigational
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Miconazole.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Miconazole.Approved, Nutraceutical
ClotrimazoleThe metabolism of Miconazole can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Miconazole.Approved
CobicistatThe metabolism of Miconazole can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Miconazole.Approved
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Miconazole.Approved
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Miconazole.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Miconazole.Approved
CrizotinibThe metabolism of Miconazole can be decreased when combined with Crizotinib.Approved
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Miconazole.Approved, Investigational, Vet Approved
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Miconazole.Approved
DabrafenibThe serum concentration of Miconazole can be decreased when it is combined with Dabrafenib.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Miconazole.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Miconazole.Approved
DarodipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Darodipine.Experimental
DarunavirThe metabolism of Miconazole can be decreased when combined with Darunavir.Approved
DasatinibThe serum concentration of Miconazole can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Miconazole.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Miconazole.Approved
DeferasiroxThe serum concentration of Miconazole can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Miconazole can be decreased when combined with Delavirdine.Approved
DexamethasoneThe serum concentration of Miconazole can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Miconazole.Approved, Illicit, Vet Approved
DicoumarolThe serum concentration of Dicoumarol can be increased when it is combined with Miconazole.Approved
DidanosineDidanosine can cause a decrease in the absorption of Miconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Miconazole.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Miconazole.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Miconazole.Approved
DihydroergotamineThe metabolism of Miconazole can be decreased when combined with Dihydroergotamine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Miconazole.Illicit
DiltiazemThe risk or severity of adverse effects can be increased when Miconazole is combined with Diltiazem.Approved
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Miconazole.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Miconazole.Approved, Investigational
DofetilideThe metabolism of Dofetilide can be decreased when combined with Miconazole.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
DotarizineThe risk or severity of adverse effects can be increased when Miconazole is combined with Dotarizine.Investigational
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Miconazole.Approved, Investigational
DoxycyclineThe metabolism of Miconazole can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronedaroneThe metabolism of Miconazole can be decreased when combined with Dronedarone.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Miconazole.Approved
EfavirenzThe serum concentration of Miconazole can be decreased when it is combined with Efavirenz.Approved, Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Efonidipine.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Miconazole.Approved, Investigational
EnzalutamideThe serum concentration of Miconazole can be decreased when it is combined with Enzalutamide.Approved
EperisoneThe risk or severity of adverse effects can be increased when Miconazole is combined with Eperisone.Approved, Investigational
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Miconazole.Approved, Investigational
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Miconazole.Approved, Investigational
ErythromycinThe metabolism of Miconazole can be decreased when combined with Erythromycin.Approved, Vet Approved
Eslicarbazepine acetateThe serum concentration of Miconazole can be decreased when it is combined with Eslicarbazepine acetate.Approved
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Miconazole.Approved, Vet Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Miconazole.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Miconazole.Approved
Ethyl biscoumacetateThe serum concentration of Ethyl biscoumacetate can be increased when it is combined with Miconazole.Withdrawn
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Miconazole.Approved
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Miconazole.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Miconazole.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Miconazole.Approved
FelodipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Felodipine.Approved, Investigational
FendilineThe risk or severity of adverse effects can be increased when Miconazole is combined with Fendiline.Withdrawn
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Miconazole.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Miconazole.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Miconazole.Approved
FluconazoleThe metabolism of Miconazole can be decreased when combined with Fluconazole.Approved
FluindioneThe serum concentration of Fluindione can be increased when it is combined with Miconazole.Investigational
FlunarizineThe risk or severity of adverse effects can be increased when Miconazole is combined with Flunarizine.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Miconazole.Approved
FluvoxamineThe metabolism of Miconazole can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Miconazole can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Miconazole can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Miconazole can be decreased when it is combined with Fosphenytoin.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Miconazole.Approved
Fusidic AcidThe serum concentration of Miconazole can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Miconazole is combined with Gabapentin.Approved, Investigational
GallopamilThe risk or severity of adverse effects can be increased when Miconazole is combined with Gallopamil.Investigational
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Miconazole.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Miconazole.Approved
GlibornurideMiconazole may increase the hypoglycemic activities of Glibornuride.Withdrawn
GliclazideMiconazole may increase the hypoglycemic activities of Gliclazide.Approved
GlimepirideMiconazole may increase the hypoglycemic activities of Glimepiride.Approved
GlipizideMiconazole may increase the hypoglycemic activities of Glipizide.Approved
GliquidoneMiconazole may increase the hypoglycemic activities of Gliquidone.Approved
GlisoxepideMiconazole may increase the hypoglycemic activities of Glisoxepide.Approved
GlyburideMiconazole may increase the hypoglycemic activities of Glyburide.Approved
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Miconazole.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Miconazole.Withdrawn
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Miconazole.Approved
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Miconazole.Approved, Vet Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Miconazole.Approved
IdelalisibThe serum concentration of Miconazole can be increased when it is combined with Idelalisib.Approved
ImatinibThe metabolism of Miconazole can be decreased when combined with Imatinib.Approved
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Miconazole.Approved
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Miconazole.Approved
IndinavirThe metabolism of Miconazole can be decreased when combined with Indinavir.Approved
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Miconazole.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Miconazole.Approved, Investigational
IsavuconazoniumThe metabolism of Miconazole can be decreased when combined with Isavuconazonium.Approved, Investigational
IsradipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Isradipine.Approved
ItraconazoleThe metabolism of Miconazole can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Miconazole can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Miconazole.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Miconazole.Approved
KetoconazoleThe metabolism of Miconazole can be decreased when combined with Ketoconazole.Approved, Investigational
LacidipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Lacidipine.Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Miconazole.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Miconazole is combined with Lamotrigine.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Miconazole.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Miconazole.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Miconazole.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Miconazole.Approved
LercanidipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Lercanidipine.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Miconazole.Approved, Investigational
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Miconazole.Approved, Investigational
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Miconazole.Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Miconazole.Approved
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Miconazole.Approved
LopinavirThe metabolism of Miconazole can be decreased when combined with Lopinavir.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Miconazole.Approved
LovastatinThe metabolism of Miconazole can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Miconazole can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Miconazole can be increased when combined with Lumacaftor.Approved
Magnesium SulfateThe risk or severity of adverse effects can be increased when Miconazole is combined with Magnesium Sulfate.Approved, Vet Approved
ManidipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Manidipine.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Miconazole.Approved, Investigational
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Miconazole.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Miconazole.Approved, Vet Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Miconazole.Approved, Investigational
MibefradilThe risk or severity of adverse effects can be increased when Miconazole is combined with Mibefradil.Withdrawn
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Miconazole.Approved, Illicit
MifepristoneThe serum concentration of Miconazole can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Miconazole.Approved
MitotaneThe serum concentration of Miconazole can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Miconazole.Approved, Investigational
ModafinilThe serum concentration of Miconazole can be decreased when it is combined with Modafinil.Approved, Investigational
MorphineThe serum concentration of Morphine can be increased when it is combined with Miconazole.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Miconazole.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Miconazole.Approved
NafcillinThe serum concentration of Miconazole can be decreased when it is combined with Nafcillin.Approved
NaftopidilThe risk or severity of adverse effects can be increased when Miconazole is combined with Naftopidil.Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Miconazole.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Miconazole.Approved, Vet Approved
NefazodoneThe metabolism of Miconazole can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Miconazole can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Miconazole can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Miconazole can be increased when combined with Nevirapine.Approved
NicardipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Nicardipine.Approved
NifedipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Nifedipine.Approved
NiguldipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Niguldipine.Experimental
NilotinibThe metabolism of Miconazole can be decreased when combined with Nilotinib.Approved, Investigational
NiludipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Niludipine.Experimental
NilvadipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Nilvadipine.Approved
NimesulideThe risk or severity of adverse effects can be increased when Miconazole is combined with Nimesulide.Approved, Withdrawn
NimodipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Nimodipine.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Miconazole.Approved
NisoldipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Nisoldipine.Approved
NitrendipineThe risk or severity of adverse effects can be increased when Miconazole is combined with Nitrendipine.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Miconazole.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Miconazole.Approved, Investigational
OlaparibThe metabolism of Miconazole can be decreased when combined with Olaparib.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Miconazole.Approved
OsimertinibThe serum concentration of Miconazole can be increased when it is combined with Osimertinib.Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Miconazole.Approved, Vet Approved
PalbociclibThe serum concentration of Miconazole can be increased when it is combined with Palbociclib.Approved
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Miconazole.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Miconazole.Approved
PentobarbitalThe metabolism of Miconazole can be increased when combined with Pentobarbital.Approved, Vet Approved
PerhexilineThe risk or severity of adverse effects can be increased when Miconazole is combined with Perhexiline.Approved
PhenindioneThe serum concentration of Phenindione can be increased when it is combined with Miconazole.Approved
PhenobarbitalThe metabolism of Miconazole can be increased when combined with Phenobarbital.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Miconazole.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Miconazole.Approved, Vet Approved
PimozideMiconazole may increase the arrhythmogenic activities of Pimozide.Approved
PinaveriumThe risk or severity of adverse effects can be increased when Miconazole is combined with Pinaverium.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Miconazole.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Miconazole.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Miconazole.Approved
PosaconazoleThe metabolism of Miconazole can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Miconazole.Approved
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Miconazole.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Miconazole.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Miconazole.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Miconazole is combined with Pregabalin.Approved, Illicit, Investigational
PrenylamineThe risk or severity of adverse effects can be increased when Miconazole is combined with Prenylamine.Withdrawn
PrimidoneThe metabolism of Miconazole can be increased when combined with Primidone.Approved, Vet Approved
ProgesteroneThe therapeutic efficacy of Progesterone can be decreased when used in combination with Miconazole.Approved, Vet Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Miconazole.Approved, Investigational
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Miconazole.Approved
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Miconazole.Approved
QuinidineThe metabolism of Quinidine can be decreased when combined with Miconazole.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Miconazole.Approved
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Miconazole.Approved
RanolazineThe metabolism of Ranolazine can be decreased when combined with Miconazole.Approved, Investigational
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Miconazole.Approved
RifabutinThe metabolism of Miconazole can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Miconazole can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Miconazole can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Miconazole.Approved, Investigational
RisedronateThe risk or severity of adverse effects can be increased when Miconazole is combined with Risedronate.Approved, Investigational
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Miconazole.Approved, Investigational
RitonavirThe metabolism of Miconazole can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Miconazole.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Miconazole.Approved, Investigational
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Miconazole.Approved, Vet Approved
SaquinavirThe metabolism of Miconazole can be decreased when combined with Saquinavir.Approved, Investigational
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Miconazole.Approved
SildenafilThe metabolism of Miconazole can be decreased when combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Miconazole.Approved
SiltuximabThe serum concentration of Miconazole can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Miconazole can be increased when it is combined with Simeprevir.Approved
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Miconazole.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Miconazole.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Miconazole.Approved
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Miconazole.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Miconazole.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Miconazole.Experimental
St. John's WortThe serum concentration of Miconazole can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Miconazole can be increased when it is combined with Stiripentol.Approved
SucralfateSucralfate can cause a decrease in the absorption of Miconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SulfisoxazoleThe metabolism of Miconazole can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Miconazole.Approved, Investigational
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Miconazole.Approved, Investigational
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Miconazole.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Miconazole.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Miconazole.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Miconazole.Approved
TelaprevirThe metabolism of Miconazole can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Miconazole can be decreased when combined with Telithromycin.Approved
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Miconazole.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Miconazole.Approved
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Miconazole.Approved
TiclopidineThe metabolism of Miconazole can be decreased when combined with Ticlopidine.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Miconazole.Approved
TocilizumabThe serum concentration of Miconazole can be decreased when it is combined with Tocilizumab.Approved
TolazamideMiconazole may increase the hypoglycemic activities of Tolazamide.Approved
TolbutamideMiconazole may increase the hypoglycemic activities of Tolbutamide.Approved
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Miconazole is combined with Tolfenamic Acid.Approved
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Miconazole.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Miconazole.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Miconazole.Approved, Investigational
TranilastThe risk or severity of adverse effects can be increased when Miconazole is combined with Tranilast.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Miconazole.Approved
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Miconazole.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Miconazole.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Miconazole.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Miconazole.Approved
VenlafaxineThe metabolism of Miconazole can be decreased when combined with Venlafaxine.Approved
VerapamilThe risk or severity of adverse effects can be increased when Miconazole is combined with Verapamil.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Miconazole.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Miconazole.Approved, Investigational
VinpocetineThe risk or severity of adverse effects can be increased when Miconazole is combined with Vinpocetine.Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Miconazole.Approved
VoriconazoleThe metabolism of Miconazole can be decreased when combined with Voriconazole.Approved, Investigational
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Miconazole.Approved
XylometazolineThe risk or severity of adverse effects can be increased when Miconazole is combined with Xylometazoline.Approved
ZiconotideThe risk or severity of adverse effects can be increased when Miconazole is combined with Ziconotide.Approved
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Miconazole.Approved
ZiprasidoneThe metabolism of Miconazole can be decreased when combined with Ziprasidone.Approved
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Miconazole.Approved
Food InteractionsNot Available
References
Synthesis Reference

DrugSyn.org

US3717655
General ReferencesNot Available
External Links
ATC CodesA01AB09D01AC02J02AB01A07AC01G01AF04S02AA13D01AC52
AHFS Codes
  • 84:04.08.08
PDB EntriesNot Available
FDA labelDownload (650 KB)
MSDSDownload (73.7 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9735
Blood Brain Barrier+0.9823
Caco-2 permeable+0.6096
P-glycoprotein substrateNon-substrate0.545
P-glycoprotein inhibitor INon-inhibitor0.7958
P-glycoprotein inhibitor IIInhibitor0.8387
Renal organic cation transporterInhibitor0.6806
CYP450 2C9 substrateNon-substrate0.8407
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.7017
CYP450 1A2 substrateInhibitor0.9472
CYP450 2C9 inhibitorInhibitor0.939
CYP450 2D6 inhibitorInhibitor0.9413
CYP450 2C19 inhibitorInhibitor0.9591
CYP450 3A4 inhibitorInhibitor0.8861
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9961
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.853
BiodegradationNot ready biodegradable0.9933
Rat acute toxicity2.8478 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.5
hERG inhibition (predictor II)Inhibitor0.8505
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
CreamTopical2 g/1000g
OintmentTopical2.82 g/141g
OintmentTopical1.12 g/56g
PowderTopical2 g/100mL
SprayTopical2 g/100g
CreamTopical.02 g/g
SprayTopical20 mg/g
OintmentTopical20 mg/g
CreamTopical.02 g/100g
CreamTopical
PowderTopical2 g/100g
CreamTopical20 g/1000g
Kit
TinctureTopical20 mg/mL
CreamTopical20 mg/mL
Aerosol, sprayTopical.2 g/10g
CreamTopical20 mg/g
PowderTopical1.42 g/71g
Aerosol, powderTopical20 mg/g
LiquidTopical2 g/100g
CreamTopical2 %
AerosolTopical2 %
KitVaginal
SuppositoryVaginal400 mg
CreamVaginal2 g/100g
CreamVaginal2 mg/100g
SuppositoryVaginal100 mg/1
Aerosol, powderTopical2.6 g/130g
Aerosol, sprayTopical1.3 g/131g
Aerosol, sprayTopical2.6 g/130g
Aerosol, sprayTopical3 g/150g
CreamVaginal20 mg/g
SprayTopical3 g/150g
SuppositoryVaginal100 ug/1
SuppositoryVaginal200 mg/1
PowderTopical20 mg/g
CreamTopical.3 g/14g
CreamVaginal20 mg
Capsule; cream; kitOral; Topical
SuppositoryVaginal1200 mg
Cream; insertTopical; Vaginal
CreamVaginal4 %
InsertVaginal400 mg
Cream; suppositoryTopical; Vaginal
SuppositoryVaginal100 mg
CreamVaginal2 %
CreamTopical200 mg/mg
CreamTopical.02 mL/mL
TabletBuccal50 mg/1
LiquidTopical
CreamTopical2 g/100g
CreamTopical20 mg/100g
CreamTopical.7 g/35g
Aerosol, powderTopical2.56 g/128g
CreamVaginal40 mg/g
OintmentTopical2 g/100g
Kit
LiquidTopical.3 mg/15mL
OintmentTopical
PowderTopical20.6 mg/g
Prices
Unit descriptionCostUnit
Vusion 0.25-15-81.35% Ointment 50 gm Tube284.34USD tube
Miconazole 3 3 200 mg Suppository Box51.2USD box
Monistat-Derm 2% Cream 28.35 gm Tube41.99USD tube
Monistat-Derm 2% Cream 15 gm Tube32.0USD tube
Monistat 1 combination pack16.81USD each
Monistat 7 combination pack15.96USD each
Miconazole Nitrate 2% Cream 28 gm Tube12.99USD tube
Miconazole powder4.59USD g
Monistat 1 6.5% ointment3.6USD g
Miconazole nitrate powder3.55USD g
Vusion ointment3.17USD g
Monistat-derm 2% cream1.11USD g
Miconazole nitrate 2% cream0.19USD g
CVS Pharmacy miconazole 7 cream0.18USD g
Miconazole 7 cream0.15USD g
Antifungal 2% cream0.1USD g
Micatin 2% aerosol spray0.05USD g
Lotrimin af 2% liquid spray0.04USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5514698 No1994-03-212014-03-21Us
US6153635 No2000-11-282020-11-28Us
US6916485 No2002-09-112022-09-11Us
US7651698 No2002-09-112022-09-11Us
US8147852 No2008-03-302028-03-30Us
US8518442 No2002-09-112022-09-11Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point159-163 °CNot Available
water solubility1g/100mL (20 °C)Not Available
logP6.1Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000763 mg/mLALOGPS
logP5.86ALOGPS
logP5.96ChemAxon
logS-5.7ALOGPS
pKa (Strongest Basic)6.77ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area27.05 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity103.07 m3·mol-1ChemAxon
Polarizability39.54 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-0bt9-4900000000-3f143064c2acde7e15a4View in MoNA
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzylethers. These are aromatic ethers with the general formula ROCR' (R = alkyl, aryl; R'=benzene).
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzylethers
Direct ParentBenzylethers
Alternative Parents
Substituents
  • Benzylether
  • 1,3-dichlorobenzene
  • Halobenzene
  • Chlorobenzene
  • N-substituted imidazole
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Imidazole
  • Azole
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Dialkyl ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Yeast
Pharmacological action
yes
Actions
inhibitor
General Function:
Sterol 14-demethylase activity
Specific Function:
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name:
ERG11
Uniprot ID:
P10613
Molecular Weight:
60674.965 Da
References
  1. White TC, Marr KA, Bowden RA: Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin Microbiol Rev. 1998 Apr;11(2):382-402. [PubMed:9564569 ]
  2. Ghannoum MA, Rice LB: Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin Microbiol Rev. 1999 Oct;12(4):501-17. [PubMed:10515900 ]
  3. Edlind T, Smith L, Henry K, Katiyar S, Nickels J: Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling. Mol Microbiol. 2002 Oct;46(1):257-68. [PubMed:12366848 ]
  4. Georgopapadakou NH, Walsh TJ: Antifungal agents: chemotherapeutic targets and immunologic strategies. Antimicrob Agents Chemother. 1996 Feb;40(2):279-91. [PubMed:8834867 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Tetrahydrobiopterin binding
Specific Function:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by ...
Gene Name:
NOS3
Uniprot ID:
P29474
Molecular Weight:
133287.62 Da
References
  1. Wolff DJ, Datto GA, Samatovicz RA: The dual mode of inhibition of calmodulin-dependent nitric-oxide synthase by antifungal imidazole agents. J Biol Chem. 1993 May 5;268(13):9430-6. [PubMed:7683652 ]
  2. Bogle RG, Whitley GS, Soo SC, Johnstone AP, Vallance P: Effect of anti-fungal imidazoles on mRNA levels and enzyme activity of inducible nitric oxide synthase. Br J Pharmacol. 1994 Apr;111(4):1257-61. [PubMed:7518297 ]
  3. Sennequier N, Wolan D, Stuehr DJ: Antifungal imidazoles block assembly of inducible NO synthase into an active dimer. J Biol Chem. 1999 Jan 8;274(2):930-8. [PubMed:9873034 ]
  4. Dudek RR, Conforto A, Pinto V, Wildhirt S, Suzuki H: Inhibition of endothelial nitric oxide synthase by cytochrome P-450 reductase inhibitors. Proc Soc Exp Biol Med. 1995 May;209(1):60-4. [PubMed:7536941 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Tetrahydrobiopterin binding
Specific Function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-n...
Gene Name:
NOS2
Uniprot ID:
P35228
Molecular Weight:
131116.3 Da
References
  1. Wolff DJ, Datto GA, Samatovicz RA: The dual mode of inhibition of calmodulin-dependent nitric-oxide synthase by antifungal imidazole agents. J Biol Chem. 1993 May 5;268(13):9430-6. [PubMed:7683652 ]
  2. Bogle RG, Whitley GS, Soo SC, Johnstone AP, Vallance P: Effect of anti-fungal imidazoles on mRNA levels and enzyme activity of inducible nitric oxide synthase. Br J Pharmacol. 1994 Apr;111(4):1257-61. [PubMed:7518297 ]
  3. Sennequier N, Wolan D, Stuehr DJ: Antifungal imidazoles block assembly of inducible NO synthase into an active dimer. J Biol Chem. 1999 Jan 8;274(2):930-8. [PubMed:9873034 ]
  4. Dudek RR, Conforto A, Pinto V, Wildhirt S, Suzuki H: Inhibition of endothelial nitric oxide synthase by cytochrome P-450 reductase inhibitors. Proc Soc Exp Biol Med. 1995 May;209(1):60-4. [PubMed:7536941 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated potassium channel activity
Specific Function:
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key ...
Gene Name:
KCNMA1
Uniprot ID:
Q12791
Molecular Weight:
137558.115 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Potassium channel regulator activity
Specific Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivati...
Gene Name:
KCNMB1
Uniprot ID:
Q16558
Molecular Weight:
21797.27 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Potassium channel regulator activity
Specific Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 n...
Gene Name:
KCNMB2
Uniprot ID:
Q9Y691
Molecular Weight:
27129.37 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Potassium channel regulator activity
Specific Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inac...
Gene Name:
KCNMB3
Uniprot ID:
Q9NPA1
Molecular Weight:
31603.26 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Potassium channel regulator activity
Specific Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel o...
Gene Name:
KCNMB4
Uniprot ID:
Q86W47
Molecular Weight:
23948.465 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Protein phosphatase binding
Specific Function:
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMe...
Gene Name:
KCNN4
Uniprot ID:
O15554
Molecular Weight:
47695.12 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Small conductance calcium-activated potassium channel activity
Specific Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).
Gene Name:
KCNN1
Uniprot ID:
Q92952
Molecular Weight:
59986.87 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Small conductance calcium-activated potassium channel activity
Specific Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Gene Name:
KCNN2
Uniprot ID:
Q9H2S1
Molecular Weight:
63759.03 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Small conductance calcium-activated potassium channel activity
Specific Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Gene Name:
KCNN3
Uniprot ID:
Q9UGI6
Molecular Weight:
82025.305 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Specific Function:
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are r...
Gene Name:
KCNH2
Uniprot ID:
Q12809
Molecular Weight:
126653.52 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Kikuchi K, Nagatomo T, Abe H, Kawakami K, Duff HJ, Makielski JC, January CT, Nakashima Y: Blockade of HERG cardiac K+ current by antifungal drug miconazole. Br J Pharmacol. 2005 Mar;144(6):840-8. [PubMed:15778703 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated potassium channel activity
Specific Function:
Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly.
Gene Name:
KCNH6
Uniprot ID:
Q9H252
Molecular Weight:
109923.705 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Kikuchi K, Nagatomo T, Abe H, Kawakami K, Duff HJ, Makielski JC, January CT, Nakashima Y: Blockade of HERG cardiac K+ current by antifungal drug miconazole. Br J Pharmacol. 2005 Mar;144(6):840-8. [PubMed:15778703 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated potassium channel activity
Specific Function:
Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.
Gene Name:
KCNH7
Uniprot ID:
Q9NS40
Molecular Weight:
134998.525 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Kikuchi K, Nagatomo T, Abe H, Kawakami K, Duff HJ, Makielski JC, January CT, Nakashima Y: Blockade of HERG cardiac K+ current by antifungal drug miconazole. Br J Pharmacol. 2005 Mar;144(6):840-8. [PubMed:15778703 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Sakaeda T, Iwaki K, Kakumoto M, Nishikawa M, Niwa T, Jin JS, Nakamura T, Nishiguchi K, Okamura N, Okumura K: Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs. J Pharm Pharmacol. 2005 Jun;57(6):759-64. [PubMed:15969931 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid 11-beta-monooxygenase activity
Specific Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Gene Name:
CYP11B1
Uniprot ID:
P15538
Molecular Weight:
57572.44 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Gene Name:
CYP19A1
Uniprot ID:
P11511
Molecular Weight:
57882.48 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. [PubMed:11961113 ]
  2. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
  3. Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. [PubMed:12235267 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on December 09, 2016 02:39