Hephaestin
Details
- Name
- Hephaestin
- Synonyms
- 1.-.-.-
- KIAA0698
- Gene Name
- HEPH
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049450|Hephaestin MESGHLLWALLFMQSLWPQLTDGATRVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASS FLKSDKNRIGGTYKKTIYKEYKDDSYTDEVAQPAWLGFLGPVLQAEVGDVILIHLKNFAT RPYTIHPHGVFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPAC LTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWH LNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNE IDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQAL YKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKS SSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPF SMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYF SAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAA MLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMF QGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPG HQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSR YKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHG VLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPL AICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLE SNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRAD VVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITKETE KAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQRKLR RNRRSILDDSFKLLSFKQ
- Number of residues
- 1158
- Molecular Weight
- 130447.755
- Theoretical pI
- Not Available
- GO Classification
- Functionscopper ion binding / ferrous iron binding / ferroxidase activityProcessescellular iron ion homeostasis / copper ion transport / iron ion transportComponentsbasolateral plasma membrane / integral component of membrane / intracellular / perinuclear region of cytoplasm / plasma membrane
- General Function
- Ferroxidase activity
- Specific Function
- May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.
- Pfam Domain Function
- Transmembrane Regions
- 1111-1131
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0049451|Hephaestin (HEPH) ATGTGGGCCATGGAGTCAGGCCACCTCCTCTGGGCTCTGCTGTTCATGCAGTCCTTGTGG CCTCAACTGACTGATGGAGCCACTCGAGTCTACTACCTGGGCATCCGGGATGTGCAGTGG AACTATGCTCCCAAGGGAAGAAATGTCATCACGAACCAGCCTCTGGACAGTGACATAGTG GCTTCCAGCTTCTTAAAGTCTGACAAGAACCGGATAGGGGGAACCTACAAGAAGACCATC TATAAAGAATACAAGGATGACTCATACACAGATGAAGTGGCCCAGCCTGCCTGGTTGGGC TTCCTGGGGCCAGTGTTGCAGGCTGAAGTGGGGGATGTCATTCTTATTCACCTGAAGAAT TTTGCCACTCGTCCCTATACCATCCACCCTCATGGTGTCTTCTACGAGAAGGACTCTGAA GGTTCCCTATACCCAGATGGCTCCTCTGGGCCACTGAAAGCTGATGACTCTGTTCCCCCG GGGGGCAGCCATATCTACAACTGGACCATTCCAGAAGGCCATGCACCCACCGATGCTGAC CCAGCGTGCCTCACCTGGATCTACCATTCTCATGTAGATGCTCCACGAGACATTGCAACT GGCCTAATTGGGCCTCTCATCACCTGTAAAAGAGGAGCCCTGGATGGGAACTCCCCTCCT CAACGCCAGGATGTAGACCATGATTTCTTCCTCCTCTTCAGTGTGGTAGATGAGAACCTC AGCTGGCATCTCAATGAGAACATTGCCACTTACTGCTCAGATCCTGCTTCAGTGGACAAA GAAGATGAGACATTTCAGGAGAGCAATAGGATGCATGCAATCAATGGCTTTGTTTTTGGG AATTTACCTGAGCTGAACATGTGTGCACAGAAACGTGTGGCCTGGCACTTGTTTGGCATG GGCAATGAAATTGATGTCCACACAGCATTTTTCCATGGACAGATGCTGACTACCCGTGGA CACCACACTGATGTGGCTAACATCTTTCCAGCCACCTTTGTGACTGCTGAGATGGTGCCC TGGGAACCTGGTACCTGGTTAATTAGCTGCCAAGTGAACAGTCACTTTCGAGATGGCATG CAGGCACTCTACAAGGTCAAGTCTTGCTCCATGGCCCCTCCTGTGGACCTGCTCACAGGC AAAGTTCGACAGTACTTCATTGAGGCCCATGAGATTCAATGGGACTATGGCCCGATGGGG CATGATGGGAGTACTGGGAAGAATTTGAGAGAGCCAGGCAGTATCTCAGATAAGTTTTTC CAGAAGAGCTCCAGCCGAATTGGGGGCACTTACTGGAAAGTGCGATATGAAGCCTTTCAA GATGAGACATTCCAAGAGAAGATGCATTTGGAGGAAGATAGGCATCTTGGAATCCTGGGG CCAGTGATCCGGGCTGAGGTGGGTGACACCATTCAGGTGGTCTTCTACAACCGTGCCTCC CAGCCATTCAGCATGCAGCCCCATGGGGTCTTTTATGAGAAAGACTATGAAGGCACTGTG TACAATGATGGCTCATCTTACCCTGGCTTGGTTGCCAAGCCCTTTGAGAAAGTAACATAC CGCTGGACAGTCCCCCCTCATGCCGGTCCCACTGCTCAGGATCCTGCTTGTCTCACTTGG ATGTACTTCTCTGCTGCAGATCCCATAAGAGACACAAATTCTGGCCTGGTGGGCCCGCTG CTGGTGTGCAGGGCTGGTGCCTTGGGTGCAGATGGCAAGCAGAAAGGGGTGGATAAAGAA TTCTTTCTTCTCTTCACTGTGTTGGATGAGAACAAGAGCTGGTACAGCAATGCCAATCAA GCAGCTGCTATGTTGGATTTCCGACTGCTTTCAGAGGATATTGAGGGCTTCCAAGACTCC AATCGGATGCATGCCATTAATGGGTTTCTGTTCTCTAACCTGCCCAGGCTGGACATGTGC AAGGGTGACACAGTGGCCTGGCACCTGCTCGGCCTGGGCACAGAGACTGATGTGCATGGA GTCATGTTCCAGGGCAACACTGTGCAGCTTCAGGGCATGAGGAAGGGTGCAGCTATGCTC TTTCCTCATACCTTTGTCATGGCCATCATGCAGCCTGACAACCTTGGGACATTTGAGATT TATTGCCAGGCAGGCAGCCATCGAGAAGCAGGGATGAGGGCAATCTATAATGTCTCCCAG TGTCCTGGCCACCAAGCCACCCCTCGCCAACGCTACCAAGCTGCAAGAATCTACTATATC ATGGCAGAAGAAGTAGAGTGGGACTATTGCCCTGACCGGAGCTGGGAACGGGAATGGCAC AACCAGTCTGAGAAGGACAGTTATGGTTACATTTTCCTGAGCAACAAGGATGGGCTCCTG GGTTCCAGATACAAGAAAGCTGTATTCAGGGAATACACTGATGGTACATTCAGGATCCCT CGGCCAAGGACTGGACCAGAAGAACACTTGGGAATCTTGGGTCCACTTATCAAAGGTGAA GTTGGTGATATCCTGACTGTGGTATTCAAGAATAATGCCAGCCGCCCCTACTCTGTGCAT GCTCATGGAGTGCTAGAATCTACTACTGTCTGGCCACTGGCTGCTGAGCCTGGTGAGGTG GTCACTTATCAGTGGAACATCCCAGAGAGGTCTGGCCCTGGGCCCAATGACTCTGCTTGT GTTTCCTGGATCTATTATTCTGCAGTGGATCCCATCAAGGACATGTATAGTGGCCTGGTG GGGCCCTTGGCTATCTGCCAAAAGGGCATCCTGGAGCCCCATGGAGGACGGAGTGACATG GATCGGGAATTTGCATTGTTGTTCTTGATTTTTGATGAAAATAAGTCTTGGTATTTGGAG GAAAATGTGGCAACCCATGGGTCCCAGGATCCAGGCAGTATTAACCTACAGGATGAAACT TTCTTGGAGAGCAATAAAATGCATGCAATCAATGGGAAACTCTATGCCAACCTTAGGGGT CTTACCATGTACCAAGGAGAACGAGTGGCCTGGTACATGCTGGCCATGGGCCAAGATGTG GATCTACACACCATCCACTTTCATGCAGAGAGCTTCCTCTATCGGAATGGCGAGAACTAC CGGGCAGATGTGGTGGATCTGTTCCCAGGGACTTTTGAGGTTGTGGAGATGGTGGCCAGC AACCCTGGGACATGGCTGATGCACTGCCATGTGACTGACCATGTCCATGCTGGCATGGAG ACCCTCTTCACTGTTTTTTCTCGAACAGAACACTTAAGCCCTCTCACCGTCATCACCAAA GAGACTGAAAAAGTGCCCCCCAGAGACATTGAAGAAGGCAATGTGAAGATGCTGGGCATG CAGATCCCCATAAAGAATGTTGAGATGCTGGCCTCTGTTTTGGTTGCCATTAGTGTCACC CTTCTGCTCGTTGTTCTGGCTCTTGGTGGAGTGGTTTGGTACCAACATCGACAGAGAAAG CTACGACGCAATAGGAGGTCCATCCTGGATGACAGCTTCAAGCTTCTGTCTTTCAAACAG TAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9BQS7 UniProtKB Entry Name HEPH_HUMAN HGNC ID HGNC:4866 - General References
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