Solute carrier family 2, facilitated glucose transporter member 8
Details
- Name
- Solute carrier family 2, facilitated glucose transporter member 8
- Synonyms
- Glucose transporter type 8
- Glucose transporter type X1
- GLUT-8
- GLUT8
- GLUTX1
- Gene Name
- SLC2A8
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0013546|Solute carrier family 2, facilitated glucose transporter member 8 MTPEDPEETQPLLGPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPP APRLDDAAASWFGAVVTLGAAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDV WMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVLE WRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLWGSEQGWEDPPIGAE QSFHLALLRQPGIYKPFIIGVSLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGV IQVLFTAVAALIMDRAGRRLLLVLSGVVMVFSTSAFGAYFKLTQGGPGNSSHVAISAPVS AQPVDASVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLM AFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKTLEQITAHFEGR
- Number of residues
- 477
- Molecular Weight
- 50818.54
- Theoretical pI
- Not Available
- GO Classification
- Functionsglucose binding / glucose transmembrane transporter activityProcessescarbohydrate metabolic process / glucose transmembrane transport / glucose transport / insulin receptor signaling pathway / male meiosis I / response to hypoxia / transmembrane transportComponentscytoplasmic vesicle membrane / integral component of plasma membrane / lysosomal membrane / plasma membrane / synaptic vesicle
- General Function
- Glucose transmembrane transporter activity
- Specific Function
- Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity).
- Pfam Domain Function
- Sugar_tr (PF00083)
- Transmembrane Regions
- 26-46 71-91 97-117 128-148 157-177 183-203 257-277 293-313 320-340 368-388 405-425 439-459
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0013547|Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) ATGACGCCCGAGGACCCAGAGGAAACCCAGCCGCTTCTGGGGCCTCCTGGCGGCAGCGCG CCCCGCGGCCGCCGCGTCTTCCTCGCCGCCTTCGCCGCTGCCCTGGGCCCACTCAGCTTC GGCTTCGCGCTCGGCTACAGCTCCCCGGCCATCCCTAGCCTGCAGCGCGCCGCGCCCCCG GCCCCGCGCCTGGACGACGCCGCCGCCTCCTGGTTCGGGGCTGTCGTGACCCTGGGTGCC GCGGCGGGGGGAGTGCTGGGCGGCTGGCTGGTGGACCGCGCCGGGCGCAAGCTGAGCCTC TTGCTGTGCTCCGTGCCCTTCGTGGCCGGCTTTGCCGTCATCACCGCGGCCCAGGACGTG TGGATGCTGCTGGGGGGCCGCCTCCTCACCGGCCTGGCCTGCGGTGTTGCCTCCCTAGTG GCCCCGGTCTACATCTCCGAAATCGCCTACCCAGCAGTCCGGGGGTTGCTCGGCTCCTGT GTGCAGCTAATGGTCGTCGTCGGCATCCTCCTGGCCTACCTGGCAGGCTGGGTGCTGGAG TGGCGCTGGCTGGCTGTGCTGGGCTGCGTGCCCCCCTCCCTCATGCTGCTTCTCATGTGC TTCATGCCCGAGACCCCGCGCTTCCTGCTGACTCAGCACAGGCGCCAGGAGGCCATGGCC GCCCTGCGGTTCCTGTGGGGCTCCGAGCAGGGCTGGGAAGACCCCCCCATCGGGGCTGAG CAGAGCTTTCACCTGGCCCTGCTGCGGCAGCCCGGCATCTACAAGCCCTTCATCATCGGC GTCTCCCTGATGGCCTTCCAGCAGCTGTCGGGGGTCAACGCCGTCATGTTCTATGCAGAG ACCATCTTTGAAGAGGCCAAGTTCAAGGACAGCAGCCTGGCCTCGGTCGTCGTGGGTGTC ATCCAGGTGCTGTTCACAGCTGTGGCGGCTCTCATCATGGACAGAGCAGGGCGGAGGCTG CTCCTGGTCTTGTCAGGTGTGGTCATGGTGTTCAGCACGAGTGCCTTCGGCGCCTACTTC AAGCTGACCCAGGGTGGCCCTGGCAACTCCTCGCACGTGGCCATCTCGGCGCCTGTCTCT GCACAGCCTGTTGATGCCAGCGTGGGGCTGGCCTGGCTGGCCGTGGGCAGCATGTGCCTC TTCATCGCCGGAGGTCCTCAGGCCCTATGGAGCCTTCTGGCTTGCCTCCGCTTTCTGCAT CTTCAGTGTCCTTTTCACTTTGTTCTGTGTCCCTGA
- Chromosome Location
- 9
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9NY64 UniProtKB Entry Name GTR8_HUMAN HGNC ID HGNC:13812 - General References
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- Ibberson M, Uldry M, Thorens B: GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. J Biol Chem. 2000 Feb 18;275(7):4607-12. [Article]
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