SEC14-like protein 3

Details

Name
SEC14-like protein 3
Synonyms
  • TAP2
  • Tocopherol-associated protein 2
Gene Name
SEC14L3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0000675|SEC14-like protein 3
MSGRVGDLSPKQAETLAKFRENVQDVLPALPNPDDYFLLRWLRARNFDLQKSEALLRKYM
EFRKTMDIDHILDWQPPEVIQKYMPGGLCGYDRDGCPVWYDIIGPLDPKGLLFSVTKQDL
LKTKMRDCERILHECDLQTERLGKKIETIVMIFDCEGLGLKHFWKPLVEVYQEFFGLLEE
NYPETLKFMLIVKATKLFPVGYNLMKPFLSEDTRRKIIVLGNNWKEGLLKLISPEELPAQ
FGGTLTDPDGNPKCLTKINYGGEIPKSMYVRDQVKTQYEHSVQINRGSSHQVEYEILFPG
CVLRWQFSSDGADIGFGVFLKTKMGERQRAGEMTDVLPSQRYNAHMVPEDGNLTCSEAGV
YVLRFDNTYSFVHAKKVSFTVEVLLPDEGMQKYDKELTPV
Number of residues
400
Molecular Weight
46047.835
Theoretical pI
5.97
GO Classification
Functions
lipid binding / transporter activity
Components
extracellular exosome / integral component of membrane / intracellular
General Function
Transporter activity
Specific Function
Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0010254|SEC14-like protein 3 (SEC14L3)
ATGGTGATCCAGAAGTACATGCCTGGGGGCCTGTGTGGCTATGACCGTGATGGCTGCCCC
GTGTGGTATGACATCATTGGGCCACTTGATCCCAAGGGGTTGCTCTTCTCAGTCACCAAG
CAGGACCTGCTCAAGACCAAGATGAGGGACTGTGAGCGCATCCTGCATGAGTGTGACCTG
CAGACAGAGAGGCTAGGGAAGAAGATTGAGACCATCGTGATGATATTTGACTGTGAGGGC
CTGGGACTGAAACACTTCTGGAAACCTCTGGTAGAAGTGTACCAGGAGTTCTTTGGCCTC
CTTGAAGAGAATTACCCAGAGACCCTGAAGTTCATGCTCATCGTGAAAGCTACCAAACTG
TTCCCTGTGGGCTACAACCTCATGAAGCCATTCCTGAGTGAGGACACTCGCAGGAAAATT
ATTGTGTTGGGAAATAACTGGAAGGAAGGTTTGCTGAAACTCATCAGTCCTGAGGAACTG
CCTGCCCAGTTTGGGGGCACCCTGACTGACCCAGATGGGAACCCCAAATGTTTAACCAAG
ATTAACTATGGCGGGGAGATCCCCAAGTCCATGTACGTGCGGGACCAGGTGAAGACTCAG
TACGAGCACTCGGTGCAGATCAACCGCGGCTCATCACACCAAGTGGAATACGAGATCCTA
TTTCCAGGCTGCGTTCTCAGGTGGCAGTTCTCATCTGATGGTGCGGACATCGGCTTCGGA
GTTTTCCTGAAGACCAAGATGGGGGAGCGACAGCGGGCAGGGGAGATGACAGATGTTCTA
CCCAGCCAGCGCTATAACGCCCACATGGTGCCCGAGGATGGGAACCTCACCTGCTCAGAG
GCCGGCGTCTATGTCCTACGCTTCGACAACACCTATAGCTTTGTCCACGCCAAGAAGGTC
AGCTTCACAGTGGAGGTCCTGCTCCCTGACGAGGGCATGCAGAAATATGATAAGGAGCTC
ACCCCTGTCTAG
Chromosome Location
22
Locus
22q12.2
External Identifiers
ResourceLink
UniProtKB IDQ9UDX4
UniProtKB Entry NameS14L3_HUMAN
GenBank Protein ID27803382
GenBank Gene IDAY158086
GenAtlas IDSEC14L3
HGNC IDHGNC:18655
General References
  1. Kempna P, Zingg JM, Ricciarelli R, Hierl M, Saxena S, Azzi A: Cloning of novel human SEC14p-like proteins: ligand binding and functional properties. Free Radic Biol Med. 2003 Jun 1;34(11):1458-72. [PubMed:12757856]
  2. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. [PubMed:10591208]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00163Vitamin Eapproved, nutraceutical, vet_approvedunknownDetails
DB14001alpha-Tocopherol succinateapproved, nutraceutical, vet_approvedunknownDetails
DB14002D-alpha-Tocopherol acetateapproved, nutraceutical, vet_approvedunknownDetails
DB11251Tocopherolapproved, investigationalnosubstrateDetails
DB14003alpha-Tocopherol acetateapprovednosubstrateDetails
DB11635TocofersolanapprovednosubstrateDetails
DB00163Vitamin Eapproved, nutraceutical, vet_approvedunknowncarrierDetails