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Displaying drugs 1076 - 1095 of 1095 in total

Paclitaxel

Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as...
Approved
Vet approved
Matched Synonyms: … Taxol A ... ABI-007 COMPONENT PACLITAXEL …
Matched Description: … It is available as an intravenous solution for injection and the newer formulation contains albumin-bound ... Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in ... Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... paclitaxel and encequidar ... Antineoplastic and Immunomodulating Agents ... BSEP/ABCB11 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index …
Matched Products: … Aj-paclitaxel ... Apo-paclitaxel Injectable …

Amlodipine

Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities...
Approved
Matched International brands: … Atecard-AM …
Matched Description: … associated with a lower incidence of myocardial depression and cardiac conduction abnormalities than ... Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), ... Amlodipine is commonly used in the treatment of high blood pressure and angina. …
Matched Mixtures name: … AMLODIPINE and VALSARTAN ... Amlodipine and Valsartan ... Amlodipine and Valsartan …
Matched Categories: … ACE Inhibitors and Calcium Channel Blockers ... losartan and amlodipine ... nebivolol and amlodipine ... aliskiren and amlodipine ... ramipril and amlodipine …
Matched Products: … A-B VASK 5 ... A-B VASK 10 ... AMLODIPINA AWP …

(2S,3S)-3-AMINO-4-(3,3-DIFLUOROPYRROLIDIN-1-YL)-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YLCYCLOHEXYL)BUTANAMIDE

Experimental
Matched Name: … (2S,3S)-3-AMINO-4-(3,3-DIFLUOROPYRROLIDIN-1-YL)-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN …
Matched Iupac: … 2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[(1r,4S)-4-{[1,2,4]triazolo[1,5-a] …

Irinotecan

Irinotecan is a topoisomerase inhibitor used for chemotherapy. It is a water-soluble analogue of camptothecin, which is extracted from the Chinese tree Camptotheca acuminate. The bis-piperidine side chain in the structure of irinotecan bestows enhanced water solubility. As an anticancer drug, irinotecan was first commercially available in Japan in 1994...
Approved
Investigational
Matched Description: … Both irinotecan and SN-38 mediate antitumor activity by forming a complex with topoisomerase I and blocking ... various cancers such as lung, cervical and ovarian cancer. ... This leads to the arrest of the cell cycle in the S-G2 phase and cancer cell death.[A263376] …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... UGT1A1 Substrates with a Narrow Therapeutic Index ... UGT1A9 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index …
Matched Products: … DARITEX-A …

Pantoprazole

Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zollinger-Ellison (ZE) Syndrome. It can also be...
Approved
Matched Description: … B12, and an increased risk of developing hypomagnesemia and hypocalcemia which may contribute to osteoporosis ... and bone fractures later in life. ... rapid discontinuation of PPIs such as pantoprazole may cause a rebound effect and a short term increase …
Matched Categories: … Alimentary Tract and Metabolism ... pantoprazole, amoxicillin and clarithromycin ... pantoprazole, amoxicillin, clarithromycin and metronidazole ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) ... Drugs that are Mainly Renally Excreted …
Matched Products: … Ag-pantoprazole ... Apo-pantoprazole ... Act Pantoprazole …

Rosuvastatin

Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications...
Approved
Matched Description: … to as "bad cholesterol"), and very low-density lipoprotein (VLDL). ... and for people with a moderate to high risk of development of CVD, such as those with Type 2 Diabetes ... the statin class of medications, which are used to lower the risk of cardiovascular disease and manage …
Matched Mixtures name: … Rosuvastatin and Ezetimibe ... Rosuvastatin and Ezetimibe ... Rosuvastatin and Ezetimibe …
Matched Categories: … Alimentary Tract and Metabolism ... rosuvastatin and ramipril ... rosuvastatin and valsartan ... rosuvastatin and ezetimibe ... rosuvastatin and amlodipine …
Matched Products: … Ag-rosuvastatin ... Apo-rosuvastatin ... Ach-rosuvastatin …

RWJ-800088

RWJ-800088 is a synthetic PEGylated thrombopoietin (TPO) mimetic (TPOm) peptide with no sequence homology to endogenous TPO.
Investigational
Matched Synonyms: … a synthetic PEGylated thrombopoietin (TPO) mimetic (TPOm) peptide with no sequence homology to endogenous …
Matched Description: … RWJ-800088 is a synthetic PEGylated thrombopoietin (TPO) mimetic (TPOm) peptide with no sequence homology …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Palopegteriparatide

Palopegteriparatide is a mPEG conjugated parathyroid hormone 1-34.
Investigational
Matched Synonyms: … Human parathyroid hormone (PTH) synthetic peptide fragment (1-34), conjugated at the N-terminal amino ... group via a cleavable linker to O-methylpolyethylene glycol (2 x 20 kDa mPEG); 2-methylalanyl-(1-34) …
Matched Description: … Palopegteriparatide is a mPEG conjugated parathyroid hormone 1-34. …
Matched Categories: … Sex Hormones and Insulins ... Parathyroid Hormones and Analogues …

Rivastigmine

Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
Approved
Investigational
Matched Description: … Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase ... Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Apo-rivastigmine ... Act Rivastigmine Patch 5 ... RIVASTIGMIN AL 3MG HART …

Irbesartan

Irbesartan is an angiotensin receptor blocker (ARB) indicated to treat hypertension or diabetic nephropathy.[L7456,L7459] It can also be used as part of a combination product with hydrochlorothiazide for patients not well controlled or not expected to be well controlled on monotherapy. Unlike angiotensin converting enzyme inhibitors, ARBs are not associated...
Approved
Investigational
Matched Description: … Irbesartan is an angiotensin receptor blocker (ARB) indicated to treat hypertension or diabetic nephropathy ... [L7459] Unlike angiotensin converting enzyme inhibitors, ARBs are not associated with a dry cough. ... [L7456,L7459] It can also be used as part of a combination product with [hydrochlorothiazide] for patients …
Matched Mixtures name: … Irbesartan and Hydrochlorothiazide ... Irbesartan and Hydrochlorothiazide ... Irbesartan and Hydrochlorothiazide …
Matched Categories: … irbesartan and diuretics ... irbesartan and amlodipine ... Angiotensin II receptor blockers (ARBs) and diuretics ... irbesartan, amlodipine and hydrochlorothiazide ... Angiotensin II receptor blockers (ARBs) and calcium channel blockers …
Matched Products: … N/A ... Ag-irbesartan ... Act Irbesartan …

Olezarsen

Olezarsen is an antisense oligonucleotide targeting messenger RNA for apolipoprotein C-III (APOC3).
Investigational
Matched Synonyms: … ALL-P-AMBO-5'-O-(((6-(5-((TRIS(3-(6-(2-ACETAMIDO-2-DEOXY-.BETA. ... O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RU-M5C-T-T-G-T-M5C-M5C-A-G-M5C …
Matched Description: … Olezarsen is an antisense oligonucleotide targeting messenger RNA for apolipoprotein C-III (APOC3). …

Anvatabart opadotin

Investigational
Matched Synonyms: … two engineered sites via a stable ... Arx-788 (anti-her2 mab paf- mmaf toxin oxime conjugate) ... kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody; conjugated at …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Gabapentin

Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) that was first approved for use in the United States in 1993. It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to treat neuropathic...
Approved
Investigational
Matched Description: … a relatively benign adverse effect profile, wide therapeutic index, and lack of appreciable metabolism ... It is structurally and functionally related to another GABA derivative, [pregabalin]. ... [A14097,A186179] Gabapentin has some stark advantages as compared with other anti-epileptics, such as …
Matched Categories: … Gabapentin and Prodrugs ... Amino Acids, Peptides, and Proteins …
Matched Products: … GABAPENTIN AWP ... Ag-gabapentin ... Apo-gabapentin …

Nemvaleukin alfa

Investigational
Matched Synonyms: … Fusion protein comprised of a circularly-permuted interleukin-2 (IL-2) with the extracellular domain …

Sildenafil

In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to...
Approved
Investigational
Matched Description: … it to grow in size and become erect and rigid [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614 ... and effective treatment for erectile dysfunction and since its formal approval for medical use in the ... , sildenafil is currently available generically and even as a non-prescription over the counter medication …
Matched Products: … SILDENAFIL AL ... SILDENAFIL ABC ... Ag-sildenafil …

Acyclovir

Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Acyclovir was granted FDA...
Approved
Matched Description: … Acyclovir is generally used first line in the treatment of these viruses and some products are indicated ... , herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. ... for patients as young as 6 years old. …
Matched Categories: … Acyclovir and prodrug ... Nucleosides and Nucleotides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors ... Drugs that are Mainly Renally Excreted …
Matched Products: … ACY ... Apo-acyclovir ... ACICLOVIR ABC …

Methotrexate

Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such...
Approved
Matched Description: … breast cancer and non-Hodgkin's lymphoma. ... Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and ... [A180322] This inhibition leads to suppression of inflammation as well as prevention of cell division …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Drugs that are Mainly Renally Excreted ... OAT3/SLC22A8 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Products: … AC-VONDA ... Apo-methotrexate ... Ach-methotrexate …

Tadalafil

Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibitors...
Approved
Investigational
Matched Description: … (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy. ... [L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. ... In contrast to other PDE5 inhibitors like [sildenafil], tadalafil has greater selectivity for PDE5 and …
Matched Categories: … tamsulosin and tadalafil ... macitentan and tadalafil ... ambrisentan and tadalafil ... finasteride and tadalafil ... Genito Urinary System and Sex Hormones …
Matched Products: … N/A ... TADALAFIL ABC ... Ag-tadalafil …

Pramipexole

Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a non-ergot dopamine agonist drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement) . It was first approved by the FDA in 1997 . Parkinson's Disease is...
Approved
Investigational
Matched Description: … such as tremor, rigidity, and bradykinesia (slow movement) [A176867]. ... Parkinson's Disease is one of the most common neurodegenerative disorders and causes a high level of ... Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). …
Matched Categories: … Drugs that are Mainly Renally Excreted …
Matched Products: … Apo-pramipexole ... Act Pramipexole ... Ava-pramipexole …

Quetiapine

Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high...
Approved
Matched Description: … as [clozapine] and [olanzapine]. ... in schizophrenia, major depression, and bipolar disorder. ... [L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects …
Matched Categories: … Diazepines, Oxazepines, Thiazepines and Oxepines ... Drugs that are Mainly Renally Excreted …
Matched Products: … TIM ASF XR ... Ag-quetiapine ... Apo-quetiapine …
Displaying drugs 1076 - 1095 of 1095 in total