Advanced Filter

Filter by Group

Filter by Market Availability

Clear
Displaying drugs 101 - 125 of 190 in total

Hydrocortisone probutate

Approved
Vet approved
Matched Iupac: … (1R,3aS,3bS,9aR,9bS,10S,11aS)-10-hydroxy-9a,11a-dimethyl-7-oxo-1-[2-(propanoyloxy)acetyl]-1H,2H,3H,3aH ... ,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl butanoate …
Matched Categories: … Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists ... Cytochrome P-450 Substrates ... Cytochrome P-450 CYP2C8 Inducers ... Cytochrome P-450 CYP3A Inducers …

Etrasimod

Etrasimod is a synthetic next-generation selective Sphingosine 1-phosphate (S1P) receptor modulator that targets the S1P1,4,5 with no detectable activity on S1P2 and S1P3 receptors. S1P receptors are membrane-derived lysophospholipid signaling molecules that are involved in the sequestration of circulating peripheral lymphocytes in lymph nodes. Therefore, S1P receptor modulators like etrasimod...
Approved
Matched Iupac: … 2-[(3R)-7-{[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy}-1H,2H,3H,4H-cyclopenta[b]indol-3-yl]acetic …
Matched Description: … targets the S1P1,4,5 with no detectable activity on S1P2 and S1P3 receptors ... Etrasimod is a synthetic next-generation selective Sphingosine 1-phosphate (S1P) receptor modulator that ... , with a 32% and 26% remission rate observed in UC 52 and UC 12 trials respectively. …
Matched Salts cas: … 1206123-97-8 …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Cytochrome P-450 Substrates ... Cytochrome P-450 CYP2C19 Substrates ... Cytochrome P-450 CYP2C8 Substrates ... Cytochrome P-450 CYP3A Substrates …

Bamlanivimab

Bamlanivimab (LY-CoV555, also known as LY3819253), is a synthetic monoclonal antibody (mAb) derived from one of the first blood samples in the United States from a patient who recovered from COVID-19.[A224039, L15311, L15316] Bamlanivimab is a neutralizing IgG1κ mAb directed against the SARS-CoV-2 spike (S) protein, which is described to...
Approved
Investigational
Matched Description: … [L20979] Based on phase 2 clinical trial (BLAZE-1) interim results, bamlanivimab was granted Emergency ... [A224039, L15311, L15316] Bamlanivimab is a neutralizing IgG1κ mAb directed against the SARS-CoV-2 spike ... [A224044, L20974] It is set to enter phase 3 clinical trials. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Tebentafusp

Tebentafusp is a gp100 peptide-HLA-directed CD3 T cell engager. It is a bispecific, fusion protein and first-in-class drug of immune-mobilizing monoclonal T cell receptors against cancer (ImmTACs), a recently developed cancer immunotherapy with a novel mechanism of action. ImmTACs bind to target cancer cells that express a specific antigen of...
Approved
Investigational
Matched Description: … ImmTACs bind to target cancer cells that express a specific antigen of interest and recruit cytotoxic ... [L39995] It is a bispecific, fusion protein and first-in-class drug of immune-mobilizing monoclonal T ... [A244815,A244910] Uveal melanoma is a rare ocular tumour with often poor prognosis and limited treatment …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Basiliximab

A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell...
Approved
Investigational
Matched Description: … agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known ... engineered to express plasmids containing the human heavy and light chain constant region genes and ... A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Interleukin-2 Receptor Antagonist ... Interleukin-2 Receptor Blocking Antibody ... Interleukin 2 Receptor-directed Antibody Interactions …
Matched Products: … SIMULECT 20 MG İNFÜZYON VEYA ENJEKSİYONLUK ÇÖZELTİ İÇİN TOZ VE ÇÖZÜCÜ, 1 ADET …

Tremelimumab

Tremelimumab, formerly known as ticilimumab, is a fully human IgG2 monoclonal antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). CTLA-4 is a cell surface receptor expressed on activated T cells to act as a negative regulator for T cells. By binding to CTLA-4, tremelimumab enhances T cell-mediated killing of tumours...
Approved
Investigational
Matched Description: … cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). ... Tremelimumab, formerly known as ticilimumab, is a fully human IgG2 monoclonal antibody directed against ... CTLA-4 is a cell surface receptor expressed on activated T cells to act as a negative regulator for T …
Matched Categories: … CTLA-4-directed Blocking Antibody ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Ustekinumab

Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic disease-modifying anti-rheumatic drug (bDMARDs) that...
Approved
Investigational
Matched Description: … Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin( ... [A187349] It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice ... [A187349] It is a targeted biologic disease-modifying anti-rheumatic drug (bDMARDs) that is used in the …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Skin and Mucous Membrane Agents ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Stelara Solution for Injection in Pre-Filled Syringe 90 mg/1 mL …

Zanubrutinib

Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long-term survival. BTK...
Approved
Investigational
Matched Iupac: … (7S)-2-(4-phenoxyphenyl)-7-[1-(prop-2-enoyl)piperidin-4-yl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxamide …
Matched Description: … [L39025] In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended ... and proliferation of malignant B cells. ... trial whose tumour is entirely or partially destroyed by a drug. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Antineoplastic and Immunomodulating Agents ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Belimumab

Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. BLyS levels are often elevated in immunodeficient and autoimmune disorders, such as systemic lupus erythematosus (SLE).[A251495, L42705] By binding to...
Approved
Matched Description: … Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte ... stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. ... It is produced by recombinant DNA technology in a murine cell (NS0) expression system. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … BENLYSTIA SC ... BENLYSTA 200 MG / 1 ML ... BENLYSTA SUBCUTÁNEO 200 MG / 1 ML …

Omidubicel

Omidubicel is a nicotinamide-modified allogeneic hematopoietic progenitor cell therapy derived from cord blood used as an allogeneic stem cell donor source. Umbilical blood cord cells are expanded ex-vivo and nicotinamide (a form of vitamin B3) is used as an active agent in the culture system to inhibit the differentiation and...
Approved
Investigational
Matched Description: … of high-grade human leukocyte antigen (HLA)-matching. ... Umbilical blood cord cells are expanded _ex-vivo_ and [nicotinamide] (a form of vitamin B3) is used as ... and older with blood cancers planned for umbilical cord blood transplantation following a myeloablative …

Ofatumumab

Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however, the antigen is...
Approved
Matched Description: … It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic ... works by recognizing antigens that are expressed on the tumour cells in certain cancers; however, the antigen ... has a higher affinity towards CD20. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … İNFÜZYONLUK ÇÖZELTİ KONSATRESİ İÇEREN FLAKON (3 ADET) ... İNFÜZYONLUK ÇÖZELTİ KONSATRESİ İÇEREN FLAKON (1 ADET) ... Jemvy 20 mg/0,4 mL Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Kalem, 1 ADET …

Axalimogene filolisbac

Axalimogene filolisbac is under investigation in clinical trial NCT02853604 (Study of ADXS11-001 in Subjects With High Risk Locally Advanced Cervical Cancer).
Investigational
Matched Synonyms: … Live, attenuated listeria monocytogenes bacteria, expressing human papilloma virus type 16-e7 tumor antigen …

Covid-19 Coronavirus Artificial Antigen Presenting Cell Vaccine

Through analysis of potential immunogenic targets of the SARS-Cov2 genome, a synthetic ‘minigene’ was developed using domains of viral structural proteins and a polyprotein protease. Specifically, the COVID-19 infection relies on the binding of the Spike protein to an ACEII receptor, and with the described approach, the vaccine uses these...
Investigational
Matched Synonyms: … artificial antigen -Pathogen-specific vaccine …
Matched Name: … Covid-19 Coronavirus Artificial Antigen Presenting Cell Vaccine …
Matched Description: … developed using domains of viral structural proteins and a polyprotein protease. ... As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials ... approach, the vaccine uses these engineered minigenes to express viral proteins, modify artificial antigen …

Ocaratuzumab

Ocaratuzumab is a humanized monoclonal antibody directed against CD20. It is being investigated for cancers and autoimmune disorders.
Investigational
Matched Synonyms: … surface antigen Leu-16, membrane-spanning 4-domains subfamily A member 1)) ... Immunoglobulin G1, anti-(human B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1, Bp35, leukocyte …
Matched Description: … It is being investigated for cancers and autoimmune disorders. ... Ocaratuzumab is a humanized monoclonal antibody directed against CD20. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

WU-CART-007

WU-CART-007 consists of allogeneic, fratricide-resistant genetically modified T cells transduced with a 2nd generation 4-1BB-CD3z chimeric antigen receptor targeting human CD7.
Investigational
Matched Synonyms: … chimeric antigen receptor targeting human CD7 ... an allogeneic, fratricide-resistant genetically modified T cell transduced with a 2nd generation 4-1BB-CD3z …
Matched Description: … 2nd generation 4-1BB-CD3z chimeric antigen receptor targeting human CD7. ... WU-CART-007 consists of allogeneic, fratricide-resistant genetically modified T cells transduced with a …

Zanolimumab

Zanolimumab is a fully human monoclonal antibody directed against CD4.
Investigational
Matched Synonyms: … IMMUNOGLOBULIN, ANTI-(HUMAN CD4 ANTIGEN) (HUMAN MONOCLONAL 6G5 HEAVY CHAIN), DISULPHIDE WITH HUMAN MONOCLONAL …
Matched Description: … Zanolimumab is a fully human monoclonal antibody directed against CD4. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Baloramotide

Investigational
Matched Synonyms: … Cancer testis antigen ny-eso-1 (recombinant human) ... Glycyl-l-prolyl-human cancer/testis antigen 1 (autoimmunogenic cancer/testis antigen ny-eso-1, l antigen ... family member 2 (lage-2), cancer/testis antigen 6.1, ct6.1) …

Asunercept

Asunercept is under investigation in clinical trial NCT02853565 (A Study of CAN008 for Newly Diagnosed Glioblastoma Multiforme).
Investigational
Matched Synonyms: … FAS ANTIGEN (HUMAN EXTRACELLULAR DOMAIN FRAGMENT) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN FC FRAGMENT …
Matched Description: … Asunercept is under investigation in clinical trial NCT02853565 (A Study of CAN008 for Newly Diagnosed …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Seviprotimut-L

Seviprotimut-L is under investigation in clinical trial NCT01546571 (Study of a Melanoma Vaccine in Stage Iib, Iic, and III Melanoma Patients).
Investigational
Matched Synonyms: … Human polyvalent shedded antigen vaccine …
Matched Description: … Iib, Iic, and III Melanoma Patients). ... Seviprotimut-L is under investigation in clinical trial NCT01546571 (Study of a Melanoma Vaccine in Stage …

Xaluritamig

Xaluritamig is a novel humanized bispecific T cell recruiting antibody cross-reactive to human and nonhuman primate STEAP1 and CD3.
Investigational
Matched Synonyms: … epithelial antigen of the prostate 1, STEAP1 metalloreductase) and anti-[Homo sapiens CD3, bispecific ... anti-(human CD3 antigen) (human-Mus muscul ... clone 2F3.013 N67Q γ1-chain) fusion protein with peptide linker (GGGGS)2 fusion protein with immunoglobulin …
Matched Description: … Xaluritamig is a novel humanized bispecific T cell recruiting antibody cross-reactive to human and nonhuman ... primate STEAP1 and CD3. …

Rozrolimupab

Rozrolimupab is a recombinant polyclonal antibody consisting of 25 different anti-Rhesus D (RhD) antibodies to replace existing anti-RhD hyperimmune immunoglobulins for the treatment of Idiopathic Thrombocytopenic Purpura (ITP) and the prevention of Hemolytic Disease of Newborns (HDN).
Investigational
Matched Synonyms: … Recombinant human antigen-specific polyclonal antibody (pAb) against RhD antigen expressed in Chinese …
Matched Description: … Rozrolimupab is a recombinant polyclonal antibody consisting of 25 different anti-Rhesus D (RhD) antibodies ... anti-RhD hyperimmune immunoglobulins for the treatment of Idiopathic Thrombocytopenic Purpura (ITP) and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Lemzoparlimab

Lemzoparlimab is under investigation in clinical trial NCT04912063 (Study to Evaluate Adverse Events and Movement of Lemzoparlimab in Body When Used Intravenously (IV) With Azacitidine Subcutaneously or IV and Venetoclax Orally in Participants With Acute Myeloid Leukemia and With Azacitidine With or Without Venetoclax in Participants With Myelodysplastic Syndrome).
Investigational
Matched Synonyms: … Immunoglobulin g4(228-proline), anti-(human cd47 antigen) (human monoclonal tj011133 .gamma.4-chain), ... disulfide with human monoclonal tj011133 .kappa. …
Matched Description: … Lemzoparlimab is under investigation in clinical trial NCT04912063 (Study to Evaluate Adverse Events and ... Movement of Lemzoparlimab in Body When Used Intravenously (IV) With Azacitidine Subcutaneously or IV and ... Venetoclax Orally in Participants With Acute Myeloid Leukemia and With Azacitidine With or Without Venetoclax …

Timolumab

Timolumab is a recombinant, fully-human, IgG4 immunoglobulin with antigen-binding specificity for human vascular adhesion protein-1 (VAP-1).
Investigational
Matched Synonyms: … recombinant, fully-human, IgG4 immunoglobulin with antigen-binding specificity for human vascular adhesion ... protein-1 (VAP-1) …
Matched Description: … Timolumab is a recombinant, fully-human, IgG4 immunoglobulin with antigen-binding specificity for human ... vascular adhesion protein-1 (VAP-1). …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Exbivirumab

Exbivirumab is an investigational monoclonal antibody. It is one of the active ingredients in HepeX-B, a drug product containing two human monoclonal antibodies to the hepatitis B virus (HBV) surface antigen.
Investigational
Matched Synonyms: … Immunoglobulin g, anti-(hepatitis b surface antigen) (human monoclonal 19.79.5 heavy chain), disulfide ... with human monoclonal 19.79.5 .lambda. chain, dimer …
Matched Description: … It is one of the active ingredients in HepeX-B, a drug product containing two human monoclonal antibodies ... to the hepatitis B virus (HBV) surface antigen. …

Otlertuzumab

Otlertuzumab is under investigation in clinical trial NCT01188681 (Safety and Efficacy Study of TRU-016 Plus Bendamustine vs. Bendamustine in Relapsed Chronic Lymphocytic Leukemia).
Investigational
Matched Synonyms: … Immunoglobulin, anti-(human cd antigen cd37) (synthetic human-mus musculus fragment tru-016), dimer …
Matched Description: … Otlertuzumab is under investigation in clinical trial NCT01188681 (Safety and Efficacy Study of TRU-016 …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Displaying drugs 101 - 125 of 190 in total