Displaying drugs 1401 - 1414 of 1414 in total
Xylazine
Xylazine is a clonidine analog used as a non-opioid tranquilizer in veterinary medicine and as an emetic, especially in cats.[A9095,L42675,A251420] It acts as an agonist at α2 adrenoceptors; however, its affinity is lower than the one reported for other α2 adrenergic receptor agonists such as detomidine and medetomidine. Xylazine is...
Vet approved
Matched Iupac: … N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine …
Matched Description: … [A32545] Xylazine is not approved for human use and requires a veterinary licence for its purchase and ... [L42675] Xylazine is sometimes used as an adulterant and combined with opioids and recreational drugs ... [A9096] The use of xylazine can lead to hypotension and bradycardia[A9092,A9093], and when combined with …
Matched Categories: … Hypnotics and Sedatives ... Heterocyclic Compounds, 1-Ring ... Adrenergic alpha-2 Receptor Agonists …
Matched Description: … [A32545] Xylazine is not approved for human use and requires a veterinary licence for its purchase and ... [L42675] Xylazine is sometimes used as an adulterant and combined with opioids and recreational drugs ... [A9096] The use of xylazine can lead to hypotension and bradycardia[A9092,A9093], and when combined with …
Matched Categories: … Hypnotics and Sedatives ... Heterocyclic Compounds, 1-Ring ... Adrenergic alpha-2 Receptor Agonists …
Velusetrag
Velusetrag has been used in trials studying the treatment of Gastroparesis and Alzheimer's Disease. It is a highly selective serotonin receptor agonist effective in patients with chronic constipation. It is being developed by Theravance. Velusetrag was discovered by Theravance through the application of its multivalent drug design in a research...
Investigational
Matched Iupac: … 2-oxo-1-(propan-2-yl)-1,2-dihydroquinoline-3-carboxamide ... N-[(1R,3R,5S)-8-[(2R)-2-hydroxy-3-(N-methylmethanesulfonamido)propyl]-8-azabicyclo[3.2.1]octan-3-yl]- …
Matched Description: … Velusetrag has been used in trials studying the treatment of Gastroparesis and Alzheimer's Disease. …
Matched Description: … Velusetrag has been used in trials studying the treatment of Gastroparesis and Alzheimer's Disease. …
Sufugolix
Investigational
Matched Iupac: … 1-[4-(5-{[benzyl(methyl)amino]methyl}-1-[(2,6-difluorophenyl)methyl]-2,4-dioxo-3-phenyl-1H,2H,3H,4H-thieno …
Nabiximols
Nabiximols (tradename Sativex®) is a whole plant extract from the Cannabis species Cannabis sativa L. that has been purified into the active components CBD (cannabidiol) and THC (delta-9-tetrahydrocannabinol). For trademark purposes, purified CBD is branded as Nabidiolex®, while THC is purified as the product Tetrabinex®. Sativex® is available in a...
Investigational
Matched Iupac: … (prop-1-en-2-yl)cyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol ... (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6H,6aH,7H,8H,10aH-benzo[c]isochromen-1-ol; 2-[(1R,6R)-3-methyl-6- …
Matched Description: … (CB1R) and Cannabinoid-2 (CB2R) receptors. ... resin of the marijuana plant, both of which interact with the cannabinoid receptors found in the human ... Sativex® is available in a 1:1 formulation of THC:CBD as an oro-mucosal pump spray used for treatment …
Matched Categories: … Cannabinoids and similars …
Matched Description: … (CB1R) and Cannabinoid-2 (CB2R) receptors. ... resin of the marijuana plant, both of which interact with the cannabinoid receptors found in the human ... Sativex® is available in a 1:1 formulation of THC:CBD as an oro-mucosal pump spray used for treatment …
Matched Categories: … Cannabinoids and similars …
Morniflumate
Morniflumate is a non-steroidal anti-inflammatory drug with antipyretic properties. It is the morpholinoethyl ester of niflumic acid . In one study, post morniflumate ingestion, physical examination and clinical symptoms of those with bronchitis showed improvement .
Experimental
Matched Iupac: … 2-(morpholin-4-yl)ethyl 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylate …
Matched Description: … In one study, post morniflumate ingestion, physical examination and clinical symptoms of those with bronchitis …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Matched Description: … In one study, post morniflumate ingestion, physical examination and clinical symptoms of those with bronchitis …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Rimiducid
Rimiducid is a lipid-permeable tacrolimus analogue and a protein dimerizer. It was designed to overcome limitations of current cellular immunotherapies used for cancer and other blood disorders by enhancing the control of the immune cell activity and function. When administered via chemically-inducible dimerization (CID) technologies, rimiducid binds to switch proteins...
Investigational
Matched Iupac: … (1R)-3-(3,4-dimethoxyphenyl)-1-[3-({[2-(2-{3-[(1R)-3-(3,4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl ... )-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate ... )butanoyl]piperidine-2-carbonyloxy]propyl]phenoxy}acetamido)ethyl]carbamoyl}methoxy)phenyl]propyl (2S …
Matched Description: … Rimiducid is a lipid-permeable tacrolimus analogue and a protein dimerizer. ... blood disorders by enhancing the control of the immune cell activity and function. ... It was designed to overcome limitations of current cellular immunotherapies used for cancer and other …
Matched Description: … Rimiducid is a lipid-permeable tacrolimus analogue and a protein dimerizer. ... blood disorders by enhancing the control of the immune cell activity and function. ... It was designed to overcome limitations of current cellular immunotherapies used for cancer and other …
MMDA
MMDA, or 3-methoxy-4,5-methylenedioxyamphetamine, is a member of the amphetamine drug class with stimulant and psychedelic properties. It also acts as an entheogen and an entactogen. MMDA bears resemblance to the psychopharmacologically active essential oils elemicin and myristicin found in nutmeg. The effects of MMDA includes feelings of euphoria and warmth,...
Experimental
Illicit
Matched Iupac: … 1-(7-methoxy-2H-1,3-benzodioxol-5-yl)propan-2-amine …
Matched Description: … It also acts as an entheogen and an entactogen. ... or 3-methoxy-4,5-methylenedioxyamphetamine, is a member of the amphetamine drug class with stimulant and ... The effects of MMDA includes feelings of euphoria and warmth, as well as realistic closed-eye visuals …
Matched Description: … It also acts as an entheogen and an entactogen. ... or 3-methoxy-4,5-methylenedioxyamphetamine, is a member of the amphetamine drug class with stimulant and ... The effects of MMDA includes feelings of euphoria and warmth, as well as realistic closed-eye visuals …
Covid-19 Coronavirus Artificial Antigen Presenting Cell Vaccine
Through analysis of potential immunogenic targets of the SARS-Cov2 genome, a synthetic ‘minigene’ was developed using domains of viral structural proteins and a polyprotein protease. Specifically, the COVID-19 infection relies on the binding of the Spike protein to an ACEII receptor, and with the described approach, the vaccine uses these...
Investigational
Matched Description: … As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials ... the SARS-Cov2 genome, a synthetic ‘minigene’ was developed using domains of viral structural proteins and ... Specifically, the COVID-19 infection relies on the binding of the Spike protein to an ACEII receptor, and …
Abivertinib
Abivertinib is a tyrosine kinase inhibitor targeted against mutant forms of both human epidermal growth factor receptor (EGFR) and Bruton's tyrosine kinase (BTK). It has been investigated for use in the treatment of non-small cell lung cancer (NSCLC) and B-cell malignancies. In binding to and inhibiting EGFR and BTK receptors,...
Investigational
Matched Iupac: … N-{3-[(2-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl ... }prop-2-enamide …
Matched Description: … Abivertinib is a tyrosine kinase inhibitor targeted against mutant forms of both human epidermal growth ... In binding to and inhibiting EGFR and BTK receptors, abivertinib exerts immunomodulatory effects by preventing ... factor receptor (EGFR) and Bruton's tyrosine kinase (BTK). …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … Abivertinib is a tyrosine kinase inhibitor targeted against mutant forms of both human epidermal growth ... In binding to and inhibiting EGFR and BTK receptors, abivertinib exerts immunomodulatory effects by preventing ... factor receptor (EGFR) and Bruton's tyrosine kinase (BTK). …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
UB-612
The UB-612 COVID-19 vaccine was developed by United Biomedical Inc Asia in Taipei as the first COVID-19 “multi-tope” protein-peptide vaccine made up of eight rationally designed components . The vaccine incorporates a strong S1-RBD component linked to a single chain fragment region (sFC) of a human IgG1, which facilitates cell...
Investigational
Matched Description: … vaccine incorporates a strong S1-RBD component linked to a single chain fragment region (sFC) of a human ... rats, toxicity studies have so far shown favourable safety for this vaccine[L30653, L30658], Phase 1 ... It was able to reduce viral load and prevent COVID-19 infection in a mouse challenge model and in rhesus …
Ezatiostat
Ezatiostat is investigated in clinical trials for treating myelodysplastic syndrome. This compound belongs to the peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen...
Investigational
Matched Iupac: … ethyl (2S)-2-amino-4-{[(1R)-2-(benzylsulfanyl)-1-{[(1R)-2-ethoxy-2-oxo-1-phenylethyl]carbamoyl}ethyl] …
Matched Description: … Ezatiostat has myelostimulant activity in preclinical rodent models and human bone marrow cultures, and ... Ezatiostat is a small molecule drug that is an analog inhibitor of glutathione S-transferase P1-1. ... differentiates granulocytes and monocytes in HL60 cells. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … Ezatiostat has myelostimulant activity in preclinical rodent models and human bone marrow cultures, and ... Ezatiostat is a small molecule drug that is an analog inhibitor of glutathione S-transferase P1-1. ... differentiates granulocytes and monocytes in HL60 cells. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Droloxifene
Droloxifene, a derivative of the triphenylethylene drug tamoxifen, is a novel selective estrogen receptor modulator (SERM). Droloxifene also exhibits more rapid pharmacokinetics, reaching peak concentrations and being eliminated much more rapidly than tamoxifen. Its higher affinity to the estrogen receptor, higher anti-estrogenic to estrogenic ratio, more effective inhibition of cell...
Investigational
Matched Iupac: … 3-[(1E)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol …
Matched Description: … over tamoxifen in the treatment of human breast cancer. ... Droloxifene appears active and tolerable. ... Droloxifene may have an effect on bone and breast tissue because it induces apoptosis. …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Description: … over tamoxifen in the treatment of human breast cancer. ... Droloxifene appears active and tolerable. ... Droloxifene may have an effect on bone and breast tissue because it induces apoptosis. …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
VPM1002
The bacille Calmette-Guérin (BCG) vaccine protects against severe extrapulmonary forms of tuberculosis (TB) but does not adequately protect against pulmonary TB -- the most prevalent form of TB. This recombinant BCG, VPM1002, has been created in response and investigated for preventing pulmonary TB in newborns and TB recurrence in adults...
Investigational
Matched Description: … As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials ... TB in newborns and TB recurrence in adults through post-exposure immunization. ... This recombinant BCG, VPM1002, has been created in response and investigated for preventing pulmonary …
Rivabazumab pegol
Rivabazumab pegol is being investigated as a treatment of Pseudomonas aeruginosa lung infections in patients with cystic fibrosis.
Investigational
Displaying drugs 1401 - 1414 of 1414 in total