Displaying drugs 126 - 150 of 14998 in total
Sorafenib
Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular carcinoma, sorafenib is also...
Approved
Investigational
Matched Synonyms: … N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea ... 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide …
Matched Iupac: … 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide …
Matched Description: … [A255852] First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ... Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. ... targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in …
Matched Categories: … UGT1A9 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Iupac: … 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide …
Matched Description: … [A255852] First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ... Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. ... targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in …
Matched Categories: … UGT1A9 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Entrectinib
Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positive solid tumors. Entrectinib's...
Approved
Investigational
Matched Synonyms: … N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide …
Matched Iupac: … N-{5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl}-4-(4-methylpiperazin-1-yl)-2-[(oxan-4-yl)amino]benzamide …
Matched Description: … [L8081] It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic ... non-small cell lung cancer and NTRK gene fusion positive solid tumors. ... Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Iupac: … N-{5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl}-4-(4-methylpiperazin-1-yl)-2-[(oxan-4-yl)amino]benzamide …
Matched Description: … [L8081] It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic ... non-small cell lung cancer and NTRK gene fusion positive solid tumors. ... Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Fenofibrate
Fenofibrate is a fibric acid derivative like clofibrate and gemfibrozil. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591]
Fenofibrate was granted FDA approval on 31 December 1993.
Approved
Matched Synonyms: … Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate ... 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester ... Isopropyl (4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl)propionate …
Matched Iupac: … propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate …
Matched Description: … Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. …
Matched Iupac: … propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate …
Matched Description: … Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. …
Chlorpheniramine
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine.
Approved
Matched Synonyms: … γ-(4-chlorophenyl)-γ-(2-pyridyl)propyldimethylamine ... γ-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine …
Matched Iupac: … [3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl]dimethylamine …
Matched Description: … A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. ... It has also been used in veterinary applications. …
Matched Mixtures name: … PRINDEX NEO ... Neo Tuss Syr ... Neo DM DROPS DM …
Matched Products: … AXCEL CHLORPHENIRAMINE-4 SYRUP 4 mg/5 ml ... คลอเฟน 4 ... SELMETOR 4 …
Matched Iupac: … [3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl]dimethylamine …
Matched Description: … A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. ... It has also been used in veterinary applications. …
Matched Mixtures name: … PRINDEX NEO ... Neo Tuss Syr ... Neo DM DROPS DM …
Matched Products: … AXCEL CHLORPHENIRAMINE-4 SYRUP 4 mg/5 ml ... คลอเฟน 4 ... SELMETOR 4 …
Phenprocoumon
Coumarin derivative that acts as a long-acting oral anticoagulant.
Approved
Investigational
Matched Synonyms: … 3-(1-Phenylpropyl)-4-hydroxycoumarin ... 3-(1'-Phenyl-propyl)-4-oxycoumarin ... 3-(alpha-Ethylbenzyl)-4-hydroxycoumarin …
Matched Iupac: … 4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one …
Matched Description: … Coumarin derivative that acts as a long-acting oral anticoagulant. …
Matched Categories: … 4-Hydroxycoumarins ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Iupac: … 4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one …
Matched Description: … Coumarin derivative that acts as a long-acting oral anticoagulant. …
Matched Categories: … 4-Hydroxycoumarins ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Pancrelipase amylase
Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands. The amylases are enzymes that help in the chemical process of digestion by hydrolizing starch into more available saccharide forms. The pancrelipase amylase is a...
Approved
Matched Synonyms: … Amylase A …
Matched Description: … Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases ... [L2509] The amylases are enzymes that help in the chemical process of digestion by hydrolizing starch ... [L2512] The pancrelipase mixture, including pancrelipase amylase, was developed by Ortho-McNeil-Janssen …
Matched Mixtures name: … Cotazym Ecs 4 ... Pancrease Mt 4 …
Matched Description: … Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases ... [L2509] The amylases are enzymes that help in the chemical process of digestion by hydrolizing starch ... [L2512] The pancrelipase mixture, including pancrelipase amylase, was developed by Ortho-McNeil-Janssen …
Matched Mixtures name: … Cotazym Ecs 4 ... Pancrease Mt 4 …
Mafenide
Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns. In 1998, mafenide acetate was approved under the FDA’s accelerated approval regulations. In November 2022, the use of mafenide acetate (powder...
Approved
Vet approved
Withdrawn
Matched Synonyms: … 4-Homosufanilamide ... 4-(aminomethyl)benzenesulfonamide …
Matched Iupac: … 4-(aminomethyl)benzene-1-sulfonamide …
Matched Description: … It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep ... In November 2022, the use of mafenide acetate (powder for 5% topical solution) was withdrawn by the FDA ... Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. …
Matched Iupac: … 4-(aminomethyl)benzene-1-sulfonamide …
Matched Description: … It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep ... In November 2022, the use of mafenide acetate (powder for 5% topical solution) was withdrawn by the FDA ... Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. …
Dobutamine
A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.
Approved
Matched Synonyms: … 4-{2-[3-(4-Hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol ... (±)-4-(2-((3-(p-hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol ... 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenylethylamine …
Matched Iupac: … 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol …
Matched Description: … It is proposed as a cardiotonic after myocardial infarction or open heart surgery. ... A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or …
Matched Mixtures name: … Dobutamine Hydrochloride in Dextrose …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Dobutamine in Dextrose ... Dobutamine Hydrochloride in Dextrose …
Matched Iupac: … 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol …
Matched Description: … It is proposed as a cardiotonic after myocardial infarction or open heart surgery. ... A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or …
Matched Mixtures name: … Dobutamine Hydrochloride in Dextrose …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Dobutamine in Dextrose ... Dobutamine Hydrochloride in Dextrose …
Elacestrant
Elacestrant is a non-steroidal small molecule and an estrogen receptor (ER) antagonist.[A256838,L44918] In January 2023, it was approved by the FDA for the treatment of ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer.[L44918,L44948] It received a similar approval in the EU in September 2023. Elacestrant binds to estrogen receptor-alpha (ERα)...
Approved
Investigational
Matched Synonyms: … (2R)-2-(2-(ethyl-((4-(2-(ethylamino)ethyl)phenyl)methyl)amino)-4-methoxy-phenyl)tetralin-6-ol ... (6R)-6-(2-(ethyl((4-(2- (ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)- 5,6,7,8-tetrahydronaphthalen ... 2-naphthalenol, 6-(2-(ethyl((4-(2-(ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydro …
Matched Iupac: … (6R)-6-{2-[ethyl({4-[2-(ethylamino)ethyl]phenyl}methyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen …
Matched Description: … [A256838,L44918] In January 2023, it was approved by the FDA for the treatment of ER-positive, HER2-negative ... [L44918,L44948] It received a similar approval in the EU in September 2023. ... Elacestrant is a non-steroidal small molecule and an estrogen receptor (ER) antagonist. …
Matched Iupac: … (6R)-6-{2-[ethyl({4-[2-(ethylamino)ethyl]phenyl}methyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen …
Matched Description: … [A256838,L44918] In January 2023, it was approved by the FDA for the treatment of ER-positive, HER2-negative ... [L44918,L44948] It received a similar approval in the EU in September 2023. ... Elacestrant is a non-steroidal small molecule and an estrogen receptor (ER) antagonist. …
Mequinol
Mequinol is a phenol used in various applications. It is used as an inhibitor for acrylic monomers and acrylonitirles, as a stabilizer for chlorinated hydrocarbons and ethyl cellulose, as an ultraviolet inhibitor, as a chemical intermediate in the manufacture of antioxidants, pharmaceuticals, plasticizers, and dyestuffs . It is found as...
Approved
Matched Synonyms: … 4-Methoxyphenol …
Matched Iupac: … 4-methoxyphenol …
Matched Description: … Mequinol is a phenol used in various applications. ... and ethyl cellulose, as an ultraviolet inhibitor, as a chemical intermediate in the manufacture of antioxidants ... It is used as an inhibitor for acrylic monomers and acrylonitirles, as a stabilizer for chlorinated hydrocarbons …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Iupac: … 4-methoxyphenol …
Matched Description: … Mequinol is a phenol used in various applications. ... and ethyl cellulose, as an ultraviolet inhibitor, as a chemical intermediate in the manufacture of antioxidants ... It is used as an inhibitor for acrylic monomers and acrylonitirles, as a stabilizer for chlorinated hydrocarbons …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Diethylamino hydroxybenzoyl hexyl benzoate
Diethylamino hydroxybenzoyl hexyl benzoate is a UV filter with high absorption in the UV-A range. Minimizing the overexposure of human skin to ultraviolet radiation that may lead to acute and chronic photodamage, diethylamino hydroxybenzoyl hexyl benzoate is an oil-soluble UV filter that may be incorporated in the oil phase of...
Approved
Matched International brands: … Uvinul A Plus …
Matched Synonyms: … Hexyl 2-(4-(diethylamino)-2-hydroxybenzoyl)benzoate …
Matched Iupac: … hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate …
Matched Description: … Diethylamino hydroxybenzoyl hexyl benzoate is a UV filter with high absorption in the UV-A range. ... It has a chemical structure similar to the classical benxophoenone drug class, and displays good photostability ... Diethylamino hydroxybenzoyl hexyl benzoate was approved in Europe in 2005, and is also marketed in the …
Matched Mixtures name: … D-one By Tamdoan Bb Light ... D-one By Tamdoan Bb Medium ... D-one By Tamdoan Sunscreen 50 …
Matched Synonyms: … Hexyl 2-(4-(diethylamino)-2-hydroxybenzoyl)benzoate …
Matched Iupac: … hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate …
Matched Description: … Diethylamino hydroxybenzoyl hexyl benzoate is a UV filter with high absorption in the UV-A range. ... It has a chemical structure similar to the classical benxophoenone drug class, and displays good photostability ... Diethylamino hydroxybenzoyl hexyl benzoate was approved in Europe in 2005, and is also marketed in the …
Matched Mixtures name: … D-one By Tamdoan Bb Light ... D-one By Tamdoan Bb Medium ... D-one By Tamdoan Sunscreen 50 …
Venetoclax
Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types...
Approved
Investigational
Matched Synonyms: … 4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro ... 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro ... 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-(3-nitro …
Matched Iupac: … 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(3-nitro-4-{[(oxan- ... 4-yl)methyl]amino}benzenesulfonyl)-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzamide …
Matched Description: … Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. ... A new indication was approved in 2018 for the treatment patients with chronic lymphocytic leukemia (CLL ... Previously, this drug was indicated only for patients with 17p gene deletion [F2130]. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Iupac: … 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(3-nitro-4-{[(oxan- ... 4-yl)methyl]amino}benzenesulfonyl)-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzamide …
Matched Description: … Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. ... A new indication was approved in 2018 for the treatment patients with chronic lymphocytic leukemia (CLL ... Previously, this drug was indicated only for patients with 17p gene deletion [F2130]. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Rofecoxib
Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 )...
Approved
Investigational
Withdrawn
Matched Synonyms: … 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone ... 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone …
Matched Iupac: … 4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one …
Matched Description: … Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and ... Rofecoxib is a solid. This compound belongs to the stilbenes. ... These are organic compounds containing a 1,2-diphenylethylene moiety. …
Matched Iupac: … 4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one …
Matched Description: … Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and ... Rofecoxib is a solid. This compound belongs to the stilbenes. ... These are organic compounds containing a 1,2-diphenylethylene moiety. …
Aztreonam
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
Approved
Matched Synonyms: … (Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino ... 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl) -2- {[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino} -2- oxoethylidene …
Matched Iupac: … -4-oxoazetidine-1-sulfonate ... (2S,3S)-3-[(2Z)-2-(2-azaniumyl-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetamido]-2-methyl …
Matched Description: … It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges ... It may cause a superinfection with gram-positive organisms. ... A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. …
Matched Salts cas: … 827611-49-4 …
Matched Products: … AZBIOS® 1G POLVO PARA RECONSTITUIR A SOLUCION INYECTABLE ... AZTREONAM 1G POLVO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE …
Matched Iupac: … -4-oxoazetidine-1-sulfonate ... (2S,3S)-3-[(2Z)-2-(2-azaniumyl-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetamido]-2-methyl …
Matched Description: … It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges ... It may cause a superinfection with gram-positive organisms. ... A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. …
Matched Salts cas: … 827611-49-4 …
Matched Products: … AZBIOS® 1G POLVO PARA RECONSTITUIR A SOLUCION INYECTABLE ... AZTREONAM 1G POLVO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE …
Olaparib
Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Olaparib...
Approved
Matched Synonyms: … 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one …
Matched Iupac: … 4-{[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorophenyl]methyl}-1,2-dihydrophthalazin-1-one …
Matched Description: … by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell ... [L41100, L40908, L43792] It was first approved by the FDA and EU in December 2014,[A246020] and by Health ... Canada in April 2016. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …
Matched Iupac: … 4-{[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorophenyl]methyl}-1,2-dihydrophthalazin-1-one …
Matched Description: … by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell ... [L41100, L40908, L43792] It was first approved by the FDA and EU in December 2014,[A246020] and by Health ... Canada in April 2016. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …
Cromoglicic acid
A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.
Approved
Matched Synonyms: … 5-[3-(2-carboxy-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylic acid …
Matched Iupac: … 5-{3-[(2-carboxy-4-oxo-4H-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylic acid …
Matched Description: … A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells ... It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect …
Matched Products: … NAZOTRAL SOLUCION 4 % ... Vistacrom Eye Ointment 4% ... OPHARCROM SOLUCION NASAL 4% …
Matched Iupac: … 5-{3-[(2-carboxy-4-oxo-4H-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylic acid …
Matched Description: … A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells ... It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect …
Matched Products: … NAZOTRAL SOLUCION 4 % ... Vistacrom Eye Ointment 4% ... OPHARCROM SOLUCION NASAL 4% …
Zavegepant
Zavegepant (BHV-3500) is a calcitonin gene-related peptide (CGRP) receptor antagonist. CGRP is released from sensory nerves and acts as a strong vasodilator, and thanks to these properties, it is involved in pain pathways. CGRP receptors are expressed in the central and peripheral nervous system; however, CGRP does not cross the...
Approved
Investigational
Matched Synonyms: … )-2-(4-(1-methyl-4-piperidinyl)-1-piperazinyl)-2-oxoethyl)- ... 1-piperidinecarboxamide, 4-(1,2-dihydro-2-oxo-3-quinolinyl)-n-((1r)-1-((7-methyl-1h-indazol-5-yl)methyl …
Matched Iupac: … N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl]-4 …
Matched Description: … Zavegepant (BHV-3500) is a calcitonin gene-related peptide (CGRP) receptor antagonist. ... In migraine, CGRP innervates pain-producing meningeal blood vessels and is released by trigeminal nerve ... Zavegepant is a third-generation CGRP receptor antagonist that is small in size and highly soluble. …
Matched Categories: … Calcitonin Gene-Related Peptide (CGRP) Antagonists ... Calcitonin Gene-Related Peptide Receptor Antagonists ... Receptors, Calcitonin Gene-Related Peptide, antagonists & inhibitors …
Matched Iupac: … N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl]-4 …
Matched Description: … Zavegepant (BHV-3500) is a calcitonin gene-related peptide (CGRP) receptor antagonist. ... In migraine, CGRP innervates pain-producing meningeal blood vessels and is released by trigeminal nerve ... Zavegepant is a third-generation CGRP receptor antagonist that is small in size and highly soluble. …
Matched Categories: … Calcitonin Gene-Related Peptide (CGRP) Antagonists ... Calcitonin Gene-Related Peptide Receptor Antagonists ... Receptors, Calcitonin Gene-Related Peptide, antagonists & inhibitors …
Aminobenzoic acid
A member of the vitamin B complex. It used to be common in sunscreening agents until found to also be a sensitizer. The potassium salt is used therapeutically in fibrotic skin disorders.
Approved
Experimental
Matched Synonyms: … 4-Carboxyaniline ... 4-aminobenzoic acid ... 1-Amino-4-carboxybenzene …
Matched Iupac: … 4-aminobenzoic acid …
Matched Description: … It used to be common in sunscreening agents until found to also be a sensitizer. ... A member of the vitamin B complex. ... The potassium salt is used therapeutically in fibrotic skin disorders. …
Matched Categories: … 4-Aminobenzoic Acid …
Matched Iupac: … 4-aminobenzoic acid …
Matched Description: … It used to be common in sunscreening agents until found to also be a sensitizer. ... A member of the vitamin B complex. ... The potassium salt is used therapeutically in fibrotic skin disorders. …
Matched Categories: … 4-Aminobenzoic Acid …
Enzacamene
Commonly known as 4-methylbenzylidene-camphor (4-MBC), enzacamene is a camphor derivative and an organic chemical UV-B filter. It is used in cosmetic products such as sunscreen to provide skin protection against UV rays. While its effects on the human reproductive system as an endocrine disruptor are being investigated, its use in...
Approved
Matched Synonyms: … 4-MBC ... 4-methylbenzylidene camphor ... 3-(4-methylbenzylidene)camphor …
Matched Iupac: … (3E)-1,7,7-trimethyl-3-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-2-one …
Matched Description: … Commonly known as 4-methylbenzylidene-camphor (4-MBC), enzacamene is a camphor derivative and an organic ... over-the-counter and cosmetic products is approved by Health Canada. ... It is used in cosmetic products such as sunscreen to provide skin protection against UV rays. …
Matched Mixtures name: … Outback 2-in-1 Insect Repellent and Protective Sunscreen …
Matched Iupac: … (3E)-1,7,7-trimethyl-3-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-2-one …
Matched Description: … Commonly known as 4-methylbenzylidene-camphor (4-MBC), enzacamene is a camphor derivative and an organic ... over-the-counter and cosmetic products is approved by Health Canada. ... It is used in cosmetic products such as sunscreen to provide skin protection against UV rays. …
Matched Mixtures name: … Outback 2-in-1 Insect Repellent and Protective Sunscreen …
Hexaminolevulinate
Hexaminolevulinate is an optical imaging drug. In solution form it is instilled intravesically for use with photodynamic blue light cystoscopy as an adjunct to white light cystoscopy. On May 28, 2010, the U.S. Food and Drug Administration (FDA) granted approval for hexaminolevulinate hydrochloride (Cysview for Intravesical Solution, Photocure ASA), as...
Approved
Matched Synonyms: … 4-Hexyloxycarbonyl-2-oxobutylammoniumchloride ... Hexyl 5-amino-4-oxopentanoate hydrochloride ... Hexyl(5-amino-4-oxopentanoat)-hydrochlorid …
Matched Iupac: … hexyl 5-amino-4-oxopentanoate …
Matched Description: … Hexaminolevulinate is manufactured under the brand Cysview® by Photocure ASA. ... invasive papillary cancer of the bladder for patients suspected or known to have lesion(s) on the basis of a ... In Europe, Hexaminolevulinate is marketed under the brand Hexvix®. …
Matched Iupac: … hexyl 5-amino-4-oxopentanoate …
Matched Description: … Hexaminolevulinate is manufactured under the brand Cysview® by Photocure ASA. ... invasive papillary cancer of the bladder for patients suspected or known to have lesion(s) on the basis of a ... In Europe, Hexaminolevulinate is marketed under the brand Hexvix®. …
Mycophenolate mofetil
Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as Cyclosporine and corticosteroids to prevent organ rejection after hepatic, renal, and cardiac transplants. It is...
Approved
Investigational
Matched Synonyms: … 2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate …
Matched Iupac: … -4-enoate ... 2-(morpholin-4-yl)ethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex …
Matched Description: … rejection in 1995. ... [L7363] It is marketed by Roche Pharmaceuticals and was granted FDA approval for the prophylaxis of transplant ... as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). …
Matched Salts cas: … 116680-01-4 …
Matched Products: … CELLCEPT 500 MG IV İNFÜZYONLUK ÇÖZELTİ İÇİN TOZ, 4 ADET …
Matched Iupac: … -4-enoate ... 2-(morpholin-4-yl)ethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex …
Matched Description: … rejection in 1995. ... [L7363] It is marketed by Roche Pharmaceuticals and was granted FDA approval for the prophylaxis of transplant ... as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). …
Matched Salts cas: … 116680-01-4 …
Matched Products: … CELLCEPT 500 MG IV İNFÜZYONLUK ÇÖZELTİ İÇİN TOZ, 4 ADET …
Conivaptan
Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2).
Approved
Investigational
Matched Synonyms: … 4'-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilide …
Matched Iupac: … N-(4-{4-methyl-3,5,9-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),2(6),3,10,12-pentaene-9-carbonyl}phenyl …
Matched Description: … It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate ... Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Products: … Vaprisol Dextrose In Plastic Container …
Matched Iupac: … N-(4-{4-methyl-3,5,9-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),2(6),3,10,12-pentaene-9-carbonyl}phenyl …
Matched Description: … It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate ... Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Products: … Vaprisol Dextrose In Plastic Container …
Loncastuximab tesirine
Relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL) are a therapeutic challenge for patients who have undergone prior systemic therapies with limited success. Prognosis is poor and more effective therapies are needed to treat relapsed/refractory cases and improve survival. On April 23 2021, the Food and Drug Administration granted accelerated...
Approved
Investigational
Matched Synonyms: … Humanized monoclonal immunoglobulin G1 antibody directed against human CD19 conjugated to SG3199 through A …
Matched Description: … Zylonta also received approval in the EU on December 22, 2022. ... Relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL) are a therapeutic challenge for patients ... [L45206] This therapy was developed by ADC Therapeutics and its accelerated approval for relapsed or …
Matched Description: … Zylonta also received approval in the EU on December 22, 2022. ... Relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL) are a therapeutic challenge for patients ... [L45206] This therapy was developed by ADC Therapeutics and its accelerated approval for relapsed or …
Alfentanil
A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Approved
Illicit
Matched Synonyms: … N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide …
Matched Iupac: … N-{1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl}-N-phenylpropanamide …
Matched Description: … A short-acting opioid anesthetic and analgesic derivative of fentanyl. …
Matched Iupac: … N-{1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl}-N-phenylpropanamide …
Matched Description: … A short-acting opioid anesthetic and analgesic derivative of fentanyl. …
Caspofungin
Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal...
Approved
Matched Synonyms: … -4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline ... (4R,5S)-5-((2-Aminoethyl)amino)-N(sup 2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans …
Matched Iupac: … ,21S,24S,25S)-3-[(1R)-3-amino-1-hydroxypropyl]-21-[(2-aminoethyl)amino]-6-[(1S,2S)-1,2-dihydroxy-2-(4- …
Matched Description: … Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug ... class called the echinocandins, as coined by Merck & Co., Inc. ... It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan …
Matched Products: … CASPOFUNGINA 50 MG/VIAL POLVO PARA RECONSTITUIR A SOLUCION INYECTABLE ... CASPOVITAE® 50 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE ... CASPOVITAE ® 70 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE …
Matched Iupac: … ,21S,24S,25S)-3-[(1R)-3-amino-1-hydroxypropyl]-21-[(2-aminoethyl)amino]-6-[(1S,2S)-1,2-dihydroxy-2-(4- …
Matched Description: … Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug ... class called the echinocandins, as coined by Merck & Co., Inc. ... It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan …
Matched Products: … CASPOFUNGINA 50 MG/VIAL POLVO PARA RECONSTITUIR A SOLUCION INYECTABLE ... CASPOVITAE® 50 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE ... CASPOVITAE ® 70 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE …
Displaying drugs 126 - 150 of 14998 in total