Chlorphenamine - DrugBank

ID Pharmacology Interactions References Trials Economics Properties Spectra Taxonomy

Targets (4)Enzymes (4)Transporters (2)

Targets (4)Enzymes (4)Transporters (2)Biointeractions (11)

Identification

Name

Chlorphenamine

Accession Number

DB01114 (APRD00001, DB09440)

Type

Small Molecule

Groups

Approved

Description

A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem]

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

1-(p-chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane

1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine

2-[p-chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine

3-(p-chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine

Chlorophenylpyridamine

Chlorphenamin

Chlorphenaminum

Chlorpheniramine

Chlorpheniramine polistirex

Chlorpheniraminum

Clorfenamina

Clorfeniramina

γ-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine

γ-(4-chlorophenyl)-γ-(2-pyridyl)propyldimethylamine

External IDs

Not Available

Product Ingredients

Ingredient	UNII	CAS	InChI Key	Details
Chlorpheniramine gluconate	79YPK3BAIT	25387-68-2	OCMSTKFGYJZBIY-IFWQJVLJSA-N	Details
Chlorpheniramine hydrochloride	5S6VUP419V	56343-98-7	NOXNCSQBTYNMHD-UHFFFAOYSA-N	Details
Chlorpheniramine maleate	V1Q0O9OJ9Z	113-92-8	DBAKFASWICGISY-BTJKTKAUSA-N	Details
Chlorpheniramine tannate	72JT935YTT	1405-56-7	KOOFUFFGNZKXFG-HBNMXAOGSA-N	Details

Product Images

Approved Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Chlorpheniramine Maleate Injection USP	Liquid	10 mg	Intramuscular; Intravenous; Subcutaneous	Omega Laboratories Ltd	Not applicable	Not applicable	Canada
Chlortripolon Inj 10mg/ml	Liquid	10 mg	Intramuscular; Intravenous; Subcutaneous	Schering Plough	1953-12-31	1999-08-04	Canada

Approved Generic Prescription Products

Not Available

Approved Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
4 Hour Allergy Relief	Tablet	4 mg/1	Oral	Better Living Brands	1992-12-19	Not applicable	US
Aller-chlor	Syrup	2 mg/5mL	Oral	Rugby	2014-03-20	Not applicable	US
Aller-chlor	Tablet	4 mg/1	Oral	A S Medication Solutions	1992-12-19	2017-06-20	US
Aller-chlor	Tablet	4 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	1992-12-19	Not applicable	US
Aller-chlor	Tablet	4 mg/1	Oral	Rugby	1992-12-19	Not applicable	US
Aller-Chlor	Syrup	2 mg/5mL	Oral	Rugby	2003-01-17	Not applicable	US
Allergy	Tablet	4 mg/1	Oral	Remedy Repack	2009-02-26	Not applicable	US
Allergy	Tablet	4 mg/1	Oral	Aidarex Pharmaceuticals LLC	1992-12-19	Not applicable	US
Allergy	Tablet	4 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2017-04-24	Not applicable	US
Allergy	Tablet	4 mg/1	Oral	Kroger	1987-07-15	Not applicable	US
Allergy	Tablet	4 mg/1	Oral	Allegiant Health	2014-12-15	Not applicable	US
Allergy	Tablet	4 mg/1	Oral	Hyvee	1991-07-30	Not applicable	US
Allergy	Tablet	4 mg/1	Oral	Sunmark (Mckesson)	1992-12-19	Not applicable	US
Allergy	Tablet	4 mg/1	Oral	A S Medication Solutions	1992-12-19	2017-06-20	US
Allergy	Tablet	4 mg/1	Oral	Major	1992-12-19	Not applicable	US
Allergy	Tablet	4 mg/1	Oral	H.E.B.	1994-10-12	Not applicable	US
Allergy	Tablet	4 mg/1	Oral	Supervalu	1992-12-19	Not applicable	US
Allergy	Tablet	4 mg/1	Oral	A S Medication Solutions	1992-12-19	2017-06-20	US
Allergy	Tablet	4 mg/1	Oral	Cardinal Health	1992-12-19	Not applicable	US
Allergy Nite	Tablet	4 mg	Oral	Bayer Inc Consumer Care	Not applicable	Not applicable	Canada
Allergy Relief	Tablet	4 mg/1	Oral	Kroger	1987-07-15	Not applicable	US
Allergy Relief	Tablet	4 mg/1	Oral	Cvs Health	1987-07-15	Not applicable	US
Allergy Relief	Tablet, coated	4 mg/1	Oral	Chain Drug Marketing Association	2014-10-01	Not applicable	US
Allergy Relief	Tablet	4 mg/1	Oral	Mc Kesson (Health Mart)	1992-12-19	Not applicable	US
Allergy Relief	Tablet	4 mg/1	Oral	Gericare Pharmaceuticals	2004-09-01	Not applicable	US
Allergy Relief	Tablet	4 mg/1	Oral	Rite Aid	1992-12-19	Not applicable	US
Allergy Relief	Tablet	4 mg/1	Oral	Chain Drug Consortium	1992-12-19	Not applicable	US
Allergy Relief	Tablet, coated	4 mg/1	Oral	Discount Drug Mart	2014-05-19	Not applicable	US
Allergy Relief	Tablet	4 mg/1	Oral	Hyvee	2016-09-29	Not applicable	US
Allergy Relief	Tablet	4 mg/1	Oral	Harmon Store Inc.	1992-12-19	Not applicable	US
Allergy Relief	Tablet, film coated, extended release	12 mg/1	Oral	Cvs Health	2010-06-15	Not applicable	US
Allergy Relief	Tablet	4 mg/1	Oral	Kareway Product, Inc.	2011-08-18	Not applicable	US
Allergy Relief	Tablet, coated	4 mg/1	Oral	Top Care	2016-11-01	Not applicable	US
Allergy Relief	Tablet	4 mg/1	Oral	Family Dollar Services	1992-12-19	2019-07-08	US
Allergy Relief 4 Hour	Tablet	4 mg/1	Oral	Win Co Foods, Llc,	1992-12-19	Not applicable	US
Allergy Relief 4 Hour	Tablet	4 mg/1	Oral	Cardinal Health	1992-12-19	Not applicable	US
Allergy Time	Tablet	4 mg/1	Oral	State of Florida DOH Central Pharmacy	2013-01-01	Not applicable	US
Allergy Time	Tablet	4 mg/1	Oral	Remedy Repack	2014-04-29	Not applicable	US
Allergy Time	Tablet	4 mg/1	Oral	Time Cap Laboratories	2011-02-08	Not applicable	US
AllergyNite	Tablet	4 mg/1	Oral	Bayer	2016-04-15	2017-01-27	US
Anti Allergy	Tablet	4 mg/1	Oral	Advance Pharmaceutical Inc.	2002-01-09	Not applicable	US
Careone Allergy Relief	Tablet	4 mg/1	Oral	American Sales Company	2004-05-18	Not applicable	US
Chlor-Allergy 4-Hour	Tablet	4 mg/1	Oral	Great Lakes Wholesale, Marketing, and Sales, Inc.	1992-12-19	Not applicable	US
Chlor-Trimeton 12 Hour	Tablet, extended release	12 mg/1	Oral	Schering Plough	2010-01-04	Not applicable	US
Chlor-Trimeton 4Hour	Tablet	4 mg/1	Oral	Bayer Health Care Llc.	1975-12-31	Not applicable	US
Chlor-tripolon	Tablet	4 mg	Oral	Bayer Inc Consumer Care	1988-12-31	Not applicable	Canada
Chlor-tripolon 12 Hour	Tablet, extended release	12 mg	Oral	Bayer Inc Consumer Care	1988-12-31	Not applicable	Canada
Chlor-tripolon Night Time Allergy Relief	Tablet	12 mg	Oral	Schering Plough	Not applicable	Not applicable	Canada
Chlorphen SR	Tablet, film coated, extended release	12 mg/1	Oral	Gm Pharmaceuticals	2010-06-15	Not applicable	US
Chlorphen-12	Tablet, film coated, extended release	12 mg/1	Oral	Kvk Tech,Inc	2010-06-15	Not applicable	US
Chlorpheniramine	Tablet	4 mg/1	Oral	L&R Distributors, Inc.	1992-12-19	Not applicable	US
Chlorpheniramine Maleate	Tablet	4 mg/1	Oral	Contract Pharmacy Services Pa	2010-08-30	Not applicable	US
Chlorpheniramine Maleate	Tablet	4 mg/1	Oral	Contract Pharmacal Corporation	2001-01-24	Not applicable	US
Chlorpheniramine Maleate	Tablet, film coated, extended release	12 mg/1	Oral	Cardinal Health	2010-12-20	Not applicable	US
Chlorpheniramine Maleate	Tablet	4 mg/1	Oral	Contract Pharmacy Services Pa	2010-08-25	Not applicable	US
Chlorpheniramine Maleate	Tablet	4 mg/1	Oral	Directrx	2014-01-01	Not applicable	US
Chlorpheniramine Maleate	Tablet	4 mg/1	Oral	Sda Laboratories	2010-05-19	Not applicable	US
Chlorpheniramine Maleate	Tablet	4 mg/1	Oral	Clinical Solutions Wholsesale	2000-05-30	2017-07-03	US
Chlorpheniramine Maleate	Tablet	4 mg/1	Oral	bryant ranch prepack	2000-05-30	Not applicable	US
Chlorpheniramine Maleate	Tablet	4 mg/1	Oral	Rugby	2000-05-30	Not applicable	US
Chlorpheniramine maleate	Tablet	4 mg/1	Oral	Contract Pharmacy Services Pa	2011-01-10	Not applicable	US
Chlorpheniramine Maleate 4 mg	Tablet	4 mg/1	Oral	Remedy Repack	2016-11-08	Not applicable	US
Chlorpheniramine Maleate 4 mg	Tablet	4 mg/1	Oral	Reliable 1 Laboratories	2015-11-01	Not applicable	US
Chlorpheniramine Maleate 4mg Tablet	Tablet	4 mg	Oral	Jamp Pharma Corporation	2005-02-25	Not applicable	Canada
Chlorpheniramine Maleate Tab 4mg	Tablet	4 mg	Oral	Bionatal Drug Co	1979-12-31	1999-07-14	Canada
Chlorpheniramine Maleate Tab 4mg	Tablet	4 mg	Oral	Everest Pharmaceuticals Ltd.	1979-12-31	1999-07-14	Canada
Chlorpheniramine Tablets, 4 mg	Tablet	4 mg	Oral	Logan Pharmaceuticals Inc.	Not applicable	Not applicable	Canada
Chlortab	Tablet	4 mg/1	Oral	Western Family Foods	2007-05-22	Not applicable	US
ChlorTabs	Tablet	4 mg/1	Oral	Walmart Stores	1992-12-19	Not applicable	US
Chlortripolon Syr 2.5mg/5ml	Syrup	2.5 mg	Oral	Schering Plough	1951-12-31	2007-08-03	Canada
Clear Choice Allergy Relief	Tablet	4 mg/1	Oral	Athlete's Needs	2012-08-23	Not applicable	US
Complete Allergy Relief 4-Hour	Tablet, coated	4 mg/1	Oral	SMART SENSE (Kmart)	2015-06-30	Not applicable	US
CVSHealth Childrens Allergy Relief Pops	Lozenge	2 mg/1	Oral	Cvs Health	2015-10-13	Not applicable	US
Ed Chlorped	Liquid	2 mL/mL	Oral	Edwards Pharmaceuticals, Inc	2011-04-28	Not applicable	US
Ed Chlorped Jr	Liquid	2 mg/5mL	Oral	Edwards Pharmaceuticals, Inc	2011-03-04	Not applicable	US
Ed-chlortan	Tablet, coated	4 mg/1	Oral	Edwards Pharmaceuticals, Inc	2011-06-07	Not applicable	US
Equaline Allergy	Tablet	4 mg/1	Oral	Supervalu	2004-08-30	Not applicable	US
Good Neighbor Pharmacy Allergy	Tablet	4 mg/1	Oral	Amerisource Bergen	1989-07-15	Not applicable	US
Good Sense Allergy	Tablet	4 mg/1	Oral	L. Perrigo Company	1991-07-29	Not applicable	US
Good Sense Allergy Relief	Tablet	4 mg/1	Oral	L. Perrigo Company	2016-09-29	Not applicable	US
Good Sense Allergy Relief 4 Hour	Tablet	4 mg/1	Oral	L. Perrigo Company	1991-07-29	Not applicable	US
Haben Herb	Capsule	1.25 mg/1	Oral	Beverly Hills Holdings Co,. Ltd.	2014-08-27	Not applicable	US
Health Mart Allergy Relief	Tablet	4 mg/1	Oral	Mc Kesson	2012-01-18	Not applicable	US
Histalon Tab 4mg	Tablet	4 mg	Oral	Icn Pharmaceuticals	1962-12-31	1998-08-13	Canada
Medique Chlorphen	Tablet	4 mg/1	Oral	Unifirst First Aid	2011-10-01	Not applicable	US
Novo-pheniram	Tablet	4 mg	Oral	Teva	1967-12-31	Not applicable	Canada
Sun Mark Allergy Antihistamine	Tablet	4 mg/1	Oral	Mc Kesson	2003-09-19	Not applicable	US
Sunmark allergy relief	Tablet	4 mg/1	Oral	Mc Kesson	2016-07-13	Not applicable	US
Teldrin Allergy Relief	Tablet	4 mg/1	Oral	Gemini Pharmaceuticals, Inc.	2010-07-05	Not applicable	US
Topcare Allergy	Tablet	4 mg/1	Oral	Topco Associates	1995-10-06	Not applicable	US
Topcare Allergy Relief 4 Hour	Tablet	4 mg/1	Oral	Topco Associates	1995-10-06	2017-09-01	US
Wal-Finate	Tablet	4 mg/1	Oral	Walgreen	1992-12-19	Not applicable	US

Unapproved/Other Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Chlorpheniramine Maleate	Tablet	4 mg/1	Oral	Cardinal Health	2011-06-06	Not applicable	US

International Brands

Name	Company
Chlo-Amine	Not Available
Chlor-Trimeton	Schering-Plough
Clofeniramina	Not Available
Haynon	Not Available
Piriton	GlaxoSmithKline

Brand mixtures

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
999 Cold Remedy	Acetaminophen Chlorphenamine	Capsule	Oral	China Resources Sanjiu Medical & Pharmaceutical Co., Ltd.	2003-07-03	Not applicable	US
999 Cold Remedy Granular	Acetaminophen Chlorphenamine	Granule	Oral	China Resources Sanjiu Medical & Pharmaceutical Co., Ltd.	2003-07-03	Not applicable	US
999 Ganmaoling Cold	Acetaminophen Caffeine Chlorphenamine	Capsule	Oral	Kingsway	2012-07-30	Not applicable	US
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, coated	Oral	AAA Pharmaceutical, Inc.	2012-12-28	Not applicable	US
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hydrochloride	Acetaminophen Chlorphenamine Phenylephrine	Tablet, coated	Oral	AAA Pharmaceutical, Inc.	2012-12-28	Not applicable	US
Acti PE	Chlorphenamine Phenylephrine	Tablet	Oral	P & L Development, LLC	2015-02-28	Not applicable	US
Actifed PE	Chlorphenamine Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Actifed PE Plus	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Advil Allergy and Congestion Relief	Chlorphenamine Ibuprofen Phenylephrine	Tablet	Oral	Navajo Manuracturing Company	2016-09-16	Not applicable	US
Advil Allergy Sinus	Chlorphenamine Ibuprofen Pseudoephedrine	Tablet, coated	Oral	Pfizer	2002-12-20	Not applicable	US
Advil Cold & Sinus Convenience Pack	Chlorphenamine Ibuprofen Ibuprofen Pseudoephedrine Pseudoephedrine	Kit; Tablet	Oral	Pfizer Laboratories Div Pfizer Inc.	2014-11-27	Not applicable	Canada
Advil Cold and Sinus Nighttime	Chlorphenamine Ibuprofen Pseudoephedrine	Tablet	Oral	Pfizer Laboratories Div Pfizer Inc.	2006-08-04	Not applicable	Canada
Advil Cold and Sinus Plus	Chlorphenamine Ibuprofen Pseudoephedrine	Tablet	Oral	Pfizer Laboratories Div Pfizer Inc.	2004-08-02	Not applicable	Canada
Alka Seltzer Plus Cold	Acetylsalicylic acid Chlorphenamine Phenylephrine	Tablet	Oral	Navajo Manuracturing Company	2016-09-17	Not applicable	US
Alka-Seltzer Plus	Acetylsalicylic acid Chlorphenamine Phenylephrine	Tablet, effervescent	Oral	Lil' Drug Store Products, Inc.	2000-01-01	Not applicable	US
Alka-Seltzer Plus Cold and Cough	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Capsule, liquid filled	Oral	Bayer Health Care Llc, Consumer Care	2011-06-01	Not applicable	US
Alka-Seltzer Plus Cold and Cough Formula	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Capsule, liquid filled	Oral	Bayer Health Care Llc.	2013-10-30	2019-04-30	US
Alka-Seltzer Plus Cold Formula (Cherry Burst)	Acetylsalicylic acid Chlorphenamine Phenylephrine	Tablet, effervescent	Oral	Bayer	2008-04-10	Not applicable	US
Alka-Seltzer Plus Cold Formula (Orange Zest)	Acetylsalicylic acid Chlorphenamine Phenylephrine	Tablet, effervescent	Oral	Bayer	2008-04-10	Not applicable	US
Alka-Seltzer Plus Cold Medicine Sparkling Original	Acetylsalicylic acid Chlorphenamine Phenylephrine	Tablet, effervescent	Oral	Bayer	2008-04-10	Not applicable	US
Alka-Seltzer Plus Cold Orange Zest	Acetylsalicylic acid Chlorphenamine Phenylephrine	Tablet, effervescent	Oral	Bayer Health Care Llc.	2017-07-15	Not applicable	US
Alka-Seltzer Plus Cold Sparkling Original	Acetylsalicylic acid Chlorphenamine Phenylephrine	Tablet, effervescent	Oral	Bayer Health Care Llc.	2017-07-03	Not applicable	US
Alka-Seltzer Plus Fast Crystals Packs Cold Formula	Acetaminophen Chlorphenamine Phenylephrine	Granule, effervescent	Oral	Bayer Health Care Llc, Consumer Care	2009-07-10	Not applicable	US
Alka-Seltzer Plus Fast Packs Cold and Flu Formula	Acetaminophen Chlorphenamine Phenylephrine	Granule, effervescent	Oral	Bayer	2010-08-01	Not applicable	US
Alka-Seltzer Plus Flu Formula	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, effervescent	Oral	Bayer	2010-08-01	Not applicable	US
Alka-Seltzer Plus Maximum Strength Cold and Cough	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Capsule, liquid filled	Oral	Bayer Health Care Llc.	2017-06-16	Not applicable	US
Alka-Seltzer Plus Maximum Strength Cold and Cough Liquid Gels with Cool Menthol Flavor Liquid Gels	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Capsule, liquid filled	Oral	Bayer Health Care Llc.	2017-06-19	Not applicable	US
Alka-Seltzer Plus Multi-Symptom Cold and Cough	Acetylsalicylic acid Chlorphenamine Dextromethorphan Phenylephrine	Tablet, effervescent	Oral	Bayer Health Care Llc.	2017-07-15	Not applicable	US
Alka-Seltzer Plus Severe Cold and Flu	Acetylsalicylic acid Chlorphenamine Dextromethorphan Phenylephrine	Tablet, effervescent	Oral	Bayer Health Care Llc.	2017-07-03	Not applicable	US
Alka-Seltzer Plus Severe Cold And Flu Formula	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Granule, effervescent	Oral	Bayer Health Care Llc, Consumer Care	2012-07-02	Not applicable	US
Alka-Seltzer Plus Severe Sinus and Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Powder, for solution	Oral	Bayer	2014-04-17	Not applicable	US
Alka-Seltzer Plus-D Multi-Symptom Sinus and Cold	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Capsule, liquid filled	Oral	Bayer Health Care Llc, Consumer Care	2013-08-01	2017-08-19	US
Allerest PE	Chlorphenamine Phenylephrine	Tablet	Oral	Insight Pharmaceuticals	2009-07-31	Not applicable	US
Allerfed	Chlorphenamine Phenylephrine	Tablet	Oral	Salado Sales, Inc.	2005-07-22	Not applicable	US
Allerfed Cold and Allergy	Chlorphenamine Phenylephrine	Tablet	Oral	Chain Drug Marketing Association	2005-07-22	Not applicable	US
Allerfed Cold and Allergy PE	Chlorphenamine Phenylephrine	Tablet	Oral	Western Family Foods	2010-07-05	Not applicable	US
Allergie Extra Fort	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Therapharma Inc.	Not applicable	Not applicable	Canada
Allergy	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	L. Perrigo Company	2014-03-20	Not applicable	US
Allergy + Sinus Relief Extra Strength Tablets	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Pharmetics (2011) Inc.	2004-08-17	Not applicable	Canada
Allergy + Sinus Relief Extra Strength Tablets PE	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Allergy + Sinus Relief Regular Caplets	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Allergy and Pain Relief Multi-Symptom	Acetaminophen Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Win Co Foods, Llc,	2005-06-28	Not applicable	US
Allergy and Sinus PE Maximum Strength	Chlorphenamine Phenylephrine	Tablet	Oral	Meijer Distribution	2005-06-09	Not applicable	US
Allergy and Sinus Relief Extra Strength	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Jamp Pharma Corporation	Not applicable	Not applicable	Canada
Allergy and Stuffy Nose	Chlorphenamine Phenylephrine	Liquid	Oral	Accudial Pharmaceutical, Inc.	2009-11-11	Not applicable	US
Allergy Multi Symptom	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Kroger	2006-08-21	Not applicable	US
Allergy Multi-Symptom	Acetaminophen Chlorphenamine Phenylephrine	Tablet, coated	Oral	American Sales Company	2011-08-01	Not applicable	US
Allergy Pain Relief	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Hyvee	2006-02-04	Not applicable	US
Allergy Relief	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Kroger	2014-01-28	Not applicable	US
Allergy Relief Multi-Symptom	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Dolgencorp	2008-03-17	Not applicable	US
Allergy Relief Multisymptom	Acetaminophen Chlorphenamine Phenylephrine	Tablet, coated	Oral	Select Corporation	2012-10-15	Not applicable	US
Allergy Sinus Medication	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Lil' Drug Store Products, Inc.	2013-11-12	Not applicable	Canada
Allergy Sinus Medication - Caplet	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Westcan Pharmaceuticals Ltd.	1996-10-11	2002-07-31	Canada
allergy sinus PE	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Publix Supermarkets, Inc.	2014-10-29	Not applicable	US
Allergy Sinus PE Pain Relief	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Publix Supermarkets, Inc.	2006-07-12	Not applicable	US
Allpanto S	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	SAMSUNG PHARM IND. CO., LTD.	2012-03-01	2017-04-14	US
Altilan CL	Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Alternative Pharmacal Corporation	2015-03-01	Not applicable	US
Ana-kit	Chlorphenamine Epinephrine	Liquid; Tablet	Intramuscular; Oral; Subcutaneous	Miles Inc. Pharmaceutical Division	1995-12-31	1998-09-25	Canada
Ana-kit (2mg/tab Orl, 1mg/ml Liq Sc Im)	Chlorphenamine Epinephrine	Liquid; Tablet	Intramuscular; Oral; Subcutaneous	Hollister Stier Laboratories Llc	1997-05-13	2002-09-05	Canada
Anakit Insect Sting Treatment Kit	Chlorphenamine Epinephrine	Liquid; Tablet	Oral; Parenteral	Hollister Stier, Unit Pharm, Division Of Miles Canada Inc.	1964-12-31	1998-09-25	Canada
Aphedrid Cold and Allergy	Chlorphenamine Phenylephrine	Tablet	Oral	Army + Air Force Exchange Service	2002-07-22	Not applicable	US
Atuss DS Tannate Suspension	Chlorphenamine Dextromethorphan Pseudoephedrine	Suspension	Oral	Atley Pharmaceuticals	2006-11-21	2017-08-29	US
Bactimicina Childrens Cough and Cold	Chlorphenamine Dextromethorphan	Liquid	Oral	DLC Laboratories, Inc.	2009-10-23	Not applicable	US
Baczol Cold Medicine	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Lex Inc	2013-02-04	Not applicable	US
Balamine DM Syrup	Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Ballay Pharmaceuticals, Inc.	2013-04-23	Not applicable	US
Bc Sinus Congestion and Pain	Acetaminophen Chlorphenamine Phenylephrine	Powder	Oral	Medtech Laboratories, Inc.	2016-03-01	Not applicable	US
Benylin 1 Nightime With Menthactin	Acetaminophen Chlorphenamine Dextromethorphan Guaifenesin Menthol	Liquid	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Benylin A-D-AH Extra Strength Caplets	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Benylin A-D-AH Regular Strength Caplets	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Benylin All-IN-one Cold & Flu Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Capsule	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Benylin All-IN-one Cold and Flu Night Extra Strength Syrup	Acetaminophen Chlorphenamine Dextromethorphan Guaifenesin Pseudoephedrine	Syrup	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2005-09-23	Not applicable	Canada
Benylin Cold & Sinus Plus	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2006-08-16	Not applicable	Canada
Benylin Cold and Sinus Night	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2008-09-01	Not applicable	Canada
Benylin D-AH for Children	Chlorphenamine Pseudoephedrine	Syrup	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Benylin DM-D-AH Chewables for Children	Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet, chewable	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Benylin DM-D-AH for Children	Chlorphenamine Dextromethorphan Pseudoephedrine	Syrup	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Benylin Extra Strength All-IN-one Cold and Flu Nightime	Acetaminophen Chlorphenamine Dextromethorphan Guaifenesin Phenylephrine	Syrup	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Benylin Extra Strength Mucus & Phlegm Plus Cold Relief Night	Acetaminophen Chlorphenamine Dextromethorphan Guaifenesin Pseudoephedrine	Syrup	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2011-08-08	Not applicable	Canada
Benylin for Children All-IN-one Cold & Fever	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Suspension	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2008-09-01	Not applicable	Canada
Benylin for Children All-IN-one Cold and Fever	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet, chewable	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2010-09-07	2016-01-22	Canada
Benylin for Children Cough Stuffy and Runny Nose	Chlorphenamine Dextromethorphan Pseudoephedrine	Syrup	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Bio-B Kids	Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Advanced Generic Corporation	2009-10-01	Not applicable	US
Bio-rytuss	Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Advanced Generic Corporation	2012-08-01	Not applicable	US
Bronchodex D Cap	Chlorphenamine Pheniramine Phenylpropanolamine	Capsule, extended release	Oral	Prodemdis Enr.	1981-12-31	2001-04-26	Canada
Broncochem Allergy Control	Chlorphenamine Phenylephrine	Syrup	Oral	Laboratorio Magnachem International Srl	2017-04-01	Not applicable	US
Broncochem Cold and Flu Caplets	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, coated	Oral	Labotorio Magnachem International Srl	2010-01-01	Not applicable	US
Broncochem Cold and Flu Tea	Acetaminophen Chlorphenamine	Granule, for solution	Oral	Laboratorio Magnachem International Srl	2013-09-01	Not applicable	US
Broncochem Expectorant II	Acetaminophen Chlorphenamine Dextromethorphan Guaifenesin Phenylephrine	Syrup	Oral	Laboratorio Magnachem International Srl	2010-01-01	Not applicable	US
Broncochem Kids Allergy Control	Chlorphenamine Dextromethorphan	Syrup	Oral	Laboratorio Magancehm International Srl	2017-05-01	Not applicable	US
Bronkids	Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Portal Pharmaceutical	2007-04-03	Not applicable	US
Buckley's Complete Extra Strength Cough, Cold and Flu Night	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	The Buckley's Company	2000-08-08	Not applicable	Canada
Calmadol Plus	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Topical	Grandall Distributing Co., Inc.	2016-06-16	Not applicable	US
CapCof	Chlorphenamine Codeine Phenylephrine	Liquid	Oral	Capital Pharmaceutical	2010-10-08	Not applicable	US
Carbaphen CH	Chlorphenamine Clofedanol Phenylephrine	Suspension	Oral	Gil Pharmaceutical Corp	2011-12-29	Not applicable	US
Carbaphen Ped CH	Chlorphenamine Clofedanol Phenylephrine	Suspension	Oral	Gil Pharmaceutical Corp	2012-03-29	Not applicable	US
Care One Cold and Allergy	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	American Sales Company	2006-09-21	Not applicable	US
Care One Cold Head Congestion	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	American Sales Company	2007-07-18	Not applicable	US
Care One Cold Multi Symptom	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	American Sales Company	2007-06-26	Not applicable	US
Care One Sinus and Allergy PE	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	American Sales Company	2006-12-12	Not applicable	US
CareOne Sinus Plus Headache	Acetaminophen Chlorphenamine Phenylephrine	Kit		American Sales Company	2016-09-21	Not applicable	US
Carepanto	Chlorphenamine Dextromethorphan	Tablet	Oral	SAMSUNG PHARM IND. CO., LTD.	2012-03-01	2017-04-14	US
Children's Advil Cold & Flu Multi-symptom	Chlorphenamine Ibuprofen Pseudoephedrine	Suspension	Oral	Pfizer Laboratories Div Pfizer Inc.	2010-01-26	Not applicable	Canada
Children's Coltalin Fruit Flavor Chewable Cold Tablets	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Fortune Pharmacal Company Limited	2002-01-09	Not applicable	Canada
Children's Nicold Medicine	Chlorphenamine Dextromethorphan Pseudoephedrine	Liquid	Oral	Tanta Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Children's Nyquil Liquid	Chlorphenamine Dextromethorphan Pseudoephedrine	Liquid	Oral	Procter And Gamble	1993-12-31	2006-07-25	Canada
Children's Tylenol Cold	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Children's Tylenol Cold and Cough	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Suspension	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1997-08-12	Not applicable	Canada
Children's Tylenol Cold Chewable Tablets	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1987-12-31	2016-01-22	Canada
Children's Tylenol Cold Liquid	Acetaminophen Chlorphenamine Pseudoephedrine	Liquid	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1987-12-31	1998-08-10	Canada
Children's Tylenol Cold Liquid With DM	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Liquid	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1990-12-31	1998-08-10	Canada
Children's Tylenol Cold Suspension	Acetaminophen Chlorphenamine Pseudoephedrine	Suspension	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1997-08-11	Not applicable	Canada
Children's Tylenol Complete Cold, Cough & Fever	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Suspension	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2012-08-31	Not applicable	Canada
Children's Tylenol Cough and Runny Nose	Acetaminophen Chlorphenamine Dextromethorphan	Suspension	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2007-06-21	2016-01-22	Canada
Childrens Coltalin	Acetaminophen Chlorphenamine Phenylephrine	Tablet, chewable	Oral	Fortune Pharmacal Company Limited	2004-03-01	Not applicable	US
Childrens Dimetapp Long Acting Cough Plus Cold	Chlorphenamine Dextromethorphan	Liquid	Oral	Richmond Division of Wyeth	2005-03-04	Not applicable	US
Childrens Dimetapp Multisymptom Cold and Flu	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Richmond Division of Wyeth	2010-10-04	2017-08-15	US
Childrens Flu Relief	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Cvs Health	2015-05-31	Not applicable	US
Childrens Multi Symptom Fever and Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Kroger	2015-06-23	Not applicable	US
Childrens Multi-Symptom Cold Plus Dye-Free	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Quality Choice (Chain Drug Marketing Association, Inc.)	2015-05-31	Not applicable	US
Childrens Plus Cold	Acetaminophen Chlorphenamine Phenylephrine	Suspension	Oral	Walgreens	2015-03-31	Not applicable	US
Childrens Plus Cold Grape	Acetaminophen Chlorphenamine Phenylephrine	Suspension	Oral	Cvs Health	2009-08-13	2017-05-11	US
Childrens Plus Cough and Runny Nose	Acetaminophen Chlorphenamine Dextromethorphan	Suspension	Oral	Major	2009-01-07	2017-06-20	US
Childrens Plus Flu	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Walgreens	2015-03-31	Not applicable	US
Childrens Plus Flu with PE	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Cvs Health	2009-09-14	2017-05-11	US
Childrens Plus Multi Symptom Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Select Brand Dist.	2013-05-10	Not applicable	US
Childrens Plus Multi Symptom Cold Dye Free	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Amerisource Bergen (Good Neighbor Pharmacy) 46122	2015-08-31	Not applicable	US
Childrens Plus Multi-Symptom Cold Grape with PE	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Good Neighbor Pharmacy	2012-01-01	Not applicable	US
Childrens Plus Multi-Symptom Grape with PE	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Best Choice	2009-03-03	2017-04-14	US
Childrens Plus Multi-Symptom with PE	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Kinray	2009-06-03	2017-08-02	US
Childrens Robitussin Cough and Cold Long-acting	Chlorphenamine Dextromethorphan	Liquid	Oral	Richmond Division of Wyeth	2004-01-01	Not applicable	US
Childrens Robitussin Nighttime Cough Long-Acting DM	Chlorphenamine Dextromethorphan	Solution	Oral	Richmond Division of Wyeth	2014-07-01	Not applicable	US
Childrens TYLENOL COLD plus COUGH plus RUNNY NOSE	Acetaminophen Chlorphenamine Dextromethorphan	Suspension	Oral	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	2017-06-26	Not applicable	US
Childrens TYLENOL COLD Plus FLU	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	2017-06-26	Not applicable	US
childrens Wal Tussin Cough and Cold	Chlorphenamine Dextromethorphan	Liquid	Oral	Walgreen	2017-08-30	Not applicable	US
Chlor Tripolon Decongest Syr	Chlorphenamine Phenylpropanolamine	Syrup	Oral	Schering Plough	1981-12-31	2000-07-11	Canada
Chlor-tripolon Day and Night	Chlorphenamine Chlorphenamine	Kit; Tablet; Tablet, extended release	Oral	Schering Plough	2007-11-05	2014-07-31	Canada
Chlor-tripolon Decon Ext Str Repetabs 12	Chlorphenamine Pseudoephedrine	Tablet, extended release	Oral	Schering Plough	1983-12-31	2006-08-01	Canada
Chlorpheniramine Maleate, Phenylephrine Hydrochloride	Chlorphenamine Phenylephrine	Tablet, coated	Oral	AAA Pharmaceutical, Inc.	2012-12-22	Not applicable	US
Codar AR	Chlorphenamine Codeine	Liquid	Oral	Respa Pharmaceuticals	2011-06-20	Not applicable	US
Codeine and Chlorpheniramine Maleate ER	Chlorphenamine Codeine	Tablet, extended release	Oral	Nexgen Pharma, Inc.	2015-09-01	Not applicable	US
Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Hyvee	2007-09-24	Not applicable	US
Cold & Cough	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Capsule	Oral	Strides Pharma Inc	Not applicable	Not applicable	Canada
Cold & Cough Extra Strength	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Capsule	Oral	Strides Pharma Inc	Not applicable	Not applicable	Canada
Cold & Stuffy Nose	Chlorphenamine Phenylephrine	Liquid	Oral	Accudial Pharmaceutical, Inc.	2010-01-11	Not applicable	Canada
Cold + Sinus Daytime Cold + Sinus Nighttime	Chlorphenamine Ibuprofen Ibuprofen Pseudoephedrine Pseudoephedrine	Kit; Tablet	Oral	Vita Health Products Inc	2014-05-23	Not applicable	Canada
Cold + Sinus Nighttime	Chlorphenamine Ibuprofen Pseudoephedrine	Tablet	Oral	Vita Health Products Inc	2015-01-01	Not applicable	Canada
Cold + Sinus Plus	Chlorphenamine Ibuprofen Pseudoephedrine	Tablet	Oral	Vita Health Products Inc	2011-04-19	Not applicable	Canada
Cold and Allergy	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Meijer Distribution	2006-09-13	Not applicable	US
Cold and Allergy Maximum Strength	Chlorphenamine Phenylephrine	Tablet	Oral	Dolgencorp, Inc. (Dollar General & Rexall)	2013-04-30	Not applicable	US
Cold and Allergy PE	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Kroger	2006-08-31	Not applicable	US
Cold and Allergy Relief	Chlorphenamine Phenylephrine	Tablet	Oral	Rite Aid	2002-07-22	Not applicable	US
Cold and Cough	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Capsule, liquid filled	Oral	Pura Cap Pharmaceutical Llc.	2017-04-06	Not applicable	US
Cold and Cough High Blood Pressure	Chlorphenamine Dextromethorphan	Tablet	Oral	Value Merchandisers	2003-05-03	Not applicable	US
Cold and Flu	Acetaminophen Chlorphenamine	Tablet, coated	Oral	Rite Aid	2005-05-31	Not applicable	US
Cold and Flu BP	Acetaminophen Chlorphenamine	Tablet, coated	Oral	L&R Distributors, Inc.	2005-05-31	Not applicable	US
Cold and Flu Daytime Severe, Nighttime Severe	Acetaminophen Chlorphenamine Dextromethorphan Guaifenesin Phenylephrine	Kit		Walgreen	2005-08-04	Not applicable	US
Cold and Flu HBP	Acetaminophen Chlorphenamine	Tablet, coated	Oral	Woonsocket Prescription Center, Incorporated	2005-05-31	Not applicable	US
Cold and Flu Nighttime Relief Syrup Extra Strength	Acetaminophen Chlorphenamine Dextromethorphan Guaifenesin Pseudoephedrine	Syrup	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Cold and Flu Relief Hbp Maximum Strength Multi-symptom	Acetaminophen Chlorphenamine Dextromethorphan	Tablet, film coated	Oral	Rite Aid	2005-06-01	Not applicable	US
Cold and Flu Severe Day Time / Night Time	Acetaminophen Chlorphenamine Dextromethorphan Guaifenesin Phenylephrine	Kit		Dolgencorp	2005-08-04	Not applicable	US
Cold and Nasal Congestion Relief Nighttime Extra Strength	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Cold and Sinus Plus	Chlorphenamine Ibuprofen Pseudoephedrine	Tablet	Oral	Marcan Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Cold Decongestant Long Acting Cap	Chlorphenamine Pheniramine Phenylpropanolamine	Capsule, extended release	Oral	Novopharm Limited	1969-12-31	2001-04-12	Canada
Cold Formula Daytime Nighttime, Non-Aspirin, Multi-Symptom	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Greenbrier International, Inc.	2005-07-21	Not applicable	US
Cold Head Congestion	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Hannaford Brothers Company	2007-12-11	Not applicable	US
Cold Head Congestion Daytime / Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		AAA Pharmaceutical, Inc.	2012-12-28	Not applicable	US
Cold Head Congestion Night Time	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Dolgencorp	2005-07-21	Not applicable	US
Cold Head Congestion Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, coated	Oral	American Sales Company	2011-06-01	Not applicable	US
Cold Medication	Acetaminophen Acetaminophen Chlorphenamine Dextromethorphan Dextromethorphan Pseudoephedrine Pseudoephedrine	Kit; Tablet	Oral	Vita Health Products Inc	2012-06-28	Not applicable	Canada
Cold Medication Extra Strength Night Time	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Pharmascience Inc	1996-09-19	2016-10-28	Canada
Cold Medication Reg Strength N Tab	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Prodemdis Enr.	1996-09-19	2010-07-15	Canada
Cold Medication Regular Nighttime Tablets	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Cold Medication Regular Nighttime Tablets PE	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Cold Medicine	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Selder, S.A. de C.V.	2011-11-15	Not applicable	US
Cold Medicine XL-3 for Children	Acetaminophen Chlorphenamine Phenylephrine	Tablet, chewable	Oral	Selder, S.A. de C.V.	2011-11-15	Not applicable	US
Cold Medicine XL3	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Selder, S.A. de C.V.	2011-11-15	Not applicable	US
Cold Medicine XL3 FORTE	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Selder, S.A. de C.V.	2017-08-01	Not applicable	US
Cold Multi Symptom Daytime Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Chain Drug Marketing Association	2013-03-06	Not applicable	US
Cold Multi Symptom Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, coated	Oral	Chain Drug Marketing Association	2009-11-13	Not applicable	US
Cold Multi Symptom Relief	Acetaminophen Acetaminophen Chlorphenamine Dextromethorphan Dextromethorphan Phenylephrine Phenylephrine	Kit; Tablet	Oral	Vita Health Products Inc	Not applicable	Not applicable	Canada
Cold Multi-Symptom	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit	Oral	L&R Distributors, Inc.	2005-07-21	Not applicable	US
Cold Multi-Symptom Daytime and Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Good Sense	2011-12-31	Not applicable	US
Cold Multi-Symptom Daytime Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		AAA Pharmaceutical, Inc.	2012-12-28	Not applicable	US
Cold Multi-Symptom Night-time	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Allegiant Health	2014-12-23	Not applicable	US
Cold Multi-Symptom Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, coated	Oral	American Sales Company	2011-06-01	Not applicable	US
Cold MULTI-SYMPTOM, DAYTIME / NIGHTTIME	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Walgreen	2005-07-21	Not applicable	US
Cold PE	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Hyvee	2007-05-27	Not applicable	US
Cold Relief	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Meijer Distribution	2007-11-09	Not applicable	US
Cold Relief Duo Pack	Acetaminophen Acetaminophen Chlorphenamine Dextromethorphan Dextromethorphan Pseudoephedrine Pseudoephedrine	Kit; Tablet	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Cold Relief Multi Symptom	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Meijer Distribution	2007-08-31	Not applicable	US
Cold Relief Multi-Symptom	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Top Care	2011-10-01	Not applicable	US
Cold Relief Multi-Symptom, Daytime, Nighttime, Non-drowsy	Acetaminophen Chlorphenamine Dextromethorphan Guaifenesin Phenylephrine	Kit		Family Dollar Services	2005-08-04	Not applicable	US
Cold Relief Nightime Tablet	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Jamp Pharma Corporation	2004-06-29	Not applicable	Canada
Cold Remedy Gan Mao Ling	Acetaminophen Caffeine Chlorphenamine	Tablet	Oral	International Nature Nutraceuticals	2003-07-28	Not applicable	US
Cold Remedy Soothing	Acetaminophen Chlorphenamine	Tablet	Oral	International Nature Nutraceuticals	1987-02-24	Not applicable	US
Cold,sore Throat Pain & Cough Ultra Strength	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder, for solution	Oral	The Winning Combination Inc.	Not applicable	Not applicable	Canada
Cold/Flu Multi-Symptom Relief Daytime/Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Dolgencorp	2008-03-29	Not applicable	US
Coldaside Cold	Acetaminophen Chlorphenamine	Tablet	Oral	Tanta Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Coldaside Cold & Flu Extra Strength	Acetaminophen Chlorphenamine Dextromethorphan	Tablet	Oral	Tanta Pharmaceuticals Inc	2009-01-01	Not applicable	Canada
Coldaside Cough & Cold	Chlorphenamine Dextromethorphan	Tablet	Oral	Tanta Pharmaceuticals Inc	2009-01-01	Not applicable	Canada
Coltalin	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Fortune Pharmacal Company Limited	2004-03-01	Not applicable	US
Coltalin Cold & Allergy Tablets	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Fortune Pharmacal Company Limited	2002-01-09	Not applicable	Canada
Coltalin-DM	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Fortune Pharmacal Company Limited	2004-03-01	Not applicable	US
Complete	Acetaminophen Acetaminophen Chlorphenamine Dextromethorphan Dextromethorphan Pseudoephedrine Pseudoephedrine	Kit; Tablet	Oral	Vita Health Products Inc	2015-05-01	Not applicable	Canada
Complete Allergy and Sinus Multi Symptom	Acetaminophen Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Great Lakes Wholesale, Marketing, and Sales, Inc.	2006-05-30	Not applicable	US
Complete One Cold and Flu Nightime Extra Strength Liquid	Acetaminophen Chlorphenamine Dextromethorphan Guaifenesin Pseudoephedrine	Liquid	Oral	Tanta Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Comtrex Cough and Cold Day/Night	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Dr Reddy's Laboratories	2013-08-01	Not applicable	US
Comtrex Maximum Strength Day / Night Severe Cold and Sinus	Acetaminophen Chlorphenamine Phenylephrine	Kit		Novartis	2010-07-01	Not applicable	US
ConRx Allergy Sinus	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Eagle Distributors,Inc.	2013-02-15	Not applicable	US
ConRx Allergy Sinus Multi-Symptoms	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Eagle Distributors,Inc.	2012-07-11	Not applicable	US
Contac Cold and Flu Maximum Strength	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Meda Pharmaceuticals Ltd	2011-07-15	Not applicable	US
Contac Cold and Flu Night	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Meda Pharmaceuticals Ltd	2014-07-01	Not applicable	US
Contac Cold Capsules	Chlorphenamine Phenylpropanolamine	Capsule, extended release	Oral	Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.	1997-07-08	2000-11-06	Canada
Contac Cold Extra Strength Capsules	Chlorphenamine Phenylpropanolamine	Capsule, extended release	Oral	Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.	1997-07-08	2000-11-06	Canada
Contac Cold Nasal Congestion-nighttime	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Glaxosmithkline Inc	2004-06-30	2008-08-01	Canada
Contac Cough Cold and Flu Caplets	Acetaminophen Chlorphenamine Dextromethorphan Phenylpropanolamine	Tablet	Oral	Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.	1994-12-31	2000-11-06	Canada
Contac Night Cough Syrup	Acetaminophen Chlorphenamine Dextromethorphan	Syrup	Oral	Glaxosmithkline Inc	2006-08-31	2009-07-28	Canada
Contact C Src	Chlorphenamine Phenylpropanolamine	Capsule, extended release	Oral	Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.	1991-12-31	1997-08-15	Canada
Copanto	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	SAMSUNG PHARM IND. CO., LTD.	2012-03-01	2017-04-14	US
Coricidin Cold & Flu	Acetaminophen Chlorphenamine	Tablet	Oral	Bayer Inc Consumer Care	2004-01-12	Not applicable	Canada
Coricidin Cold & Flu Extra Strength	Acetaminophen Chlorphenamine Dextromethorphan	Tablet	Oral	Bayer Inc Consumer Care	2004-01-12	Not applicable	Canada
Coricidin Cold & Flu Multi-symptom	Acetaminophen Chlorphenamine Dextromethorphan	Tablet	Oral	Bayer Inc Consumer Care	Not applicable	Not applicable	Canada
Coricidin Cough & Cold	Chlorphenamine Dextromethorphan	Tablet	Oral	Bayer Inc Consumer Care	2004-01-12	Not applicable	Canada
Coricidin D Flu, Nasal and Sinus	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Schering Plough Healthcare Products Canada, A Division Of Schering Canada Inc.	Not applicable	Not applicable	Canada
Coricidin D Long Acting Tab	Chlorphenamine Phenylpropanolamine	Tablet, extended release	Oral	Schering Plough	1985-12-31	2001-04-02	Canada
Coricidin D Tab	Acetylsalicylic acid Chlorphenamine Phenylpropanolamine	Tablet	Oral	Schering Plough	1981-12-31	2001-04-02	Canada
Coricidin HBP Cold and Flu	Acetaminophen Chlorphenamine	Tablet, film coated	Oral	Bayer Health Care Llc.	2013-10-01	Not applicable	US
Coricidin HBP Cough and Cold Cough Suppressant, Antihistamine	Chlorphenamine Dextromethorphan	Tablet, film coated	Oral	Bayer Health Care Llc.	2013-05-01	Not applicable	US
Coricidin HBP Day and Night	Acetaminophen Chlorphenamine Dextromethorphan Guaifenesin	Kit		Bayer Health Care Llc.	2009-08-28	Not applicable	US
Coricidin HBP Maximum Strength Flu	Acetaminophen Chlorphenamine Dextromethorphan	Tablet, film coated	Oral	Msd Consumer Care Inc.	2000-08-31	Not applicable	US
Coricidin Sinus Headache Tab	Acetaminophen Chlorphenamine Phenylpropanolamine	Tablet	Oral	Schering Plough	1993-12-31	2001-04-02	Canada
Coricidin Tab	Acetylsalicylic acid Chlorphenamine	Tablet	Oral	Schering Plough	1981-12-31	2003-07-14	Canada
Corsym Suspension	Chlorphenamine Phenylpropanolamine	Suspension	Oral	Ciba Self Medication	1994-04-21	1998-07-06	Canada
Cough & Cold	Chlorphenamine Dextromethorphan	Liquid	Oral	Accudial Pharmaceutical, Inc.	2010-01-11	Not applicable	Canada
Cough and Cold	Chlorphenamine Dextromethorphan	Liquid	Oral	Accudial Pharmaceutical, Inc.	2009-11-25	Not applicable	US
Cough and Cold HBP	Chlorphenamine Dextromethorphan	Tablet, sugar coated	Oral	Dolgencorp	2003-05-03	Not applicable	US
Cough and Cold HBP Decongestant-free	Chlorphenamine Dextromethorphan	Tablet, sugar coated	Oral	Lnk International, Inc.	2003-05-03	Not applicable	US
Cough and Cold plus	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Capsule, liquid filled	Oral	Humanwell Pura Cap Pharmaceutical (Wuhan), Ltd.	2017-03-24	Not applicable	US
Cough and Cold Relief HBP	Chlorphenamine Dextromethorphan	Tablet, sugar coated	Oral	Bedrock Brands, Llc	2003-05-03	2019-07-08	US
Cough and Cold XL3 Xtra	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Capsule, liquid filled	Oral	Progela, S.A. De C.V.	2013-03-01	Not applicable	US
Cough and Runny Nose Childrens Plus	Acetaminophen Chlorphenamine Dextromethorphan	Suspension	Oral	Topcare (Topco Associates Llc)	2015-12-31	Not applicable	US
Cough, Cold & Flu Super Strength	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder, for solution	Oral	The Winning Combination Inc.	Not applicable	Not applicable	Canada
Counteract Sinus and Allergy	Acetaminophen Chlorphenamine Phenylpropanolamine	Tablet	Oral	Melaleuca, Inc.	1997-09-26	2000-12-15	Canada
Dallergy DROPS	Chlorphenamine Phenylephrine	Liquid	Oral	Laser Pharmaceuticals Llc	2014-02-01	Not applicable	US
Day & Night Combo Pack	Acetaminophen Acetaminophen Chlorphenamine Dextromethorphan Dextromethorphan Phenylephrine Pseudoephedrine	Kit; Powder, for solution	Oral	The Winning Combination Inc.	Not applicable	Not applicable	Canada
Daytime Cold, Nighttime Cold multi-symptom	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Supervalu	2005-07-21	Not applicable	US
De-Chlor DM	Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Cypress Pharmaceuticals, Inc.	2011-07-09	Not applicable	US
Defensol D	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Menper Distributors	2012-02-21	Not applicable	US
Defensol D (Multi Symptom Effervescent Tablets)	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, effervescent	Oral	Menper Distributors	2015-12-01	Not applicable	US
DG health allergy multi symptom	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Dolgencorp	2010-01-29	Not applicable	US
DG Health Cold and Allergy	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Dolgencorp	2010-02-26	Not applicable	US
DG Health Cold Head Congestion	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Dolgencorp	2010-02-22	Not applicable	US
DG Health cold multi symptom nite time	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Dolgencorp	2009-10-05	Not applicable	US
Dg Health Sinus Congestion and Pain	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Dolgencorp	2010-01-11	Not applicable	US
Dimetapp Nighttime Cold Extra Strength Caplets	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Pfizer Laboratories Div Pfizer Inc.	2001-01-23	Not applicable	Canada
Dimetapp Nighttime Cold Tablets	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Wyeth Ltd.	2001-01-23	2006-07-24	Canada
Dometuss-DA	Chlorphenamine Phenylephrine	Liquid	Oral	Domel Laboratories	2016-01-21	Not applicable	US
Dometuss-NR	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Domel Laboratories	2016-01-21	Not applicable	US
Donatussin	Chlorphenamine Dextromethorphan Phenylephrine	Syrup	Oral	Laser Pharmaceuticals Llc	2014-02-19	Not applicable	US
Donatussin DM Drops DM	Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Laser Pharmaceuticals Llc	2005-12-20	Not applicable	US
Dristan Capsules	Acetylsalicylic acid Caffeine Chlorphenamine Phenylpropanolamine	Capsule	Oral	Whitehall Robins Inc.	1993-12-31	1999-08-04	Canada
Dristan Cold Multisymptom	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Pfizer	2005-05-05	Not applicable	US
Dristan Extra Strength Caplets	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Pfizer Laboratories Div Pfizer Inc.	1994-12-31	Not applicable	Canada
Dristan Tablets	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Pfizer Laboratories Div Pfizer Inc.	1994-12-31	Not applicable	Canada
DryMax	Chlorphenamine Methscopolamine Pseudoephedrine	Syrup	Oral	Jay Mac Pharmaceuticals	2010-01-18	2016-10-13	US
DryMax AF	Chlorphenamine Clofedanol Pseudoephedrine	Syrup	Oral	Jay Mac Pharmaceuticals	2011-09-23	2016-10-13	US
Ed A-hist	Chlorphenamine Phenylephrine	Liquid	Oral	Edwards Pharmaceuticals, Inc	2011-01-11	Not applicable	US
Ed A-hist DM	Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Edwards Pharmaceuticals, Inc	2012-09-11	Not applicable	US
Ed Chlorped D	Chlorphenamine Phenylephrine	Liquid	Oral	Edwards Pharmaceuticals, Inc	2011-06-01	Not applicable	US
Ed-A-hist DM	Chlorphenamine Dextromethorphan Phenylephrine	Tablet, coated	Oral	Edwards Pharmaceuticals, Inc	2014-10-27	Not applicable	US
Effervescent Cold Relief	Acetylsalicylic acid Chlorphenamine Phenylephrine	Tablet, effervescent	Oral	Cardinal Health	2010-07-01	Not applicable	US
Effervescent Orange Cold Relief	Acetylsalicylic acid Chlorphenamine Phenylephrine	Tablet, effervescent	Oral	Cvs Health	2017-03-10	Not applicable	US
EndaCof C	Chlorphenamine Codeine	Liquid	Oral	Larken Laboratories, Inc.	2009-05-25	2015-12-29	US
Entre-S	Chlorphenamine Dextromethorphan Pseudoephedrine	Syrup	Oral	Brookstone Pharmaceuticals, Inc.	2009-12-15	2016-12-09	US
Equaline Childrens Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Supervalu	2012-08-29	Not applicable	US
Equaline Daytime and Nighttime Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Supervalu	2009-09-03	Not applicable	US
Equaline nighttime cold multi symptom	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Supervalu	2007-09-19	Not applicable	US
Extra Fast Coltalin	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Fortune Pharmacal Company Limited	2017-04-04	Not applicable	US
Extra Strength Allergy and Sinus Relief	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Pendopharm Division Of De Pharmascience Inc	2002-02-15	2014-02-10	Canada
Extra Strength Allergy Plus Sinus Relief	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Ksl Pharmaceuticals	1995-12-31	2002-07-31	Canada
Extra Strength Allergy Sinus Medication	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.	1995-12-31	2005-07-20	Canada
Extra Strength Cold Medication Night Time Relief	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Genvion Corporation	2016-04-12	Not applicable	Canada
Extra Strength Cold Medication Nighttime Relief	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Vita Health Products Inc	1995-12-31	Not applicable	Canada
Extra Strength Cold Medication Nighttime Rlf	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.	1995-12-31	2006-07-31	Canada
Extra Strength Contac C - Src	Chlorphenamine Phenylpropanolamine	Capsule, extended release	Oral	Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.	1995-12-31	1997-08-15	Canada
Extra Strength Day and Night Cold Medication	Acetaminophen Acetaminophen Chlorphenamine Dextromethorphan Dextromethorphan Pseudoephedrine Pseudoephedrine	Kit; Tablet	Oral	Pendopharm Division Of De Pharmascience Inc	Not applicable	Not applicable	Canada
Extra Strength Neocitran Flu Night	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Kit; Powder	Oral	Novartis	1997-11-11	2016-08-02	Canada
Extra Strength Neocitran Total Night	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder, for solution	Oral	Novartis	2005-08-08	2016-08-02	Canada
Extra Strength Nighttime Cold Relief	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Pendopharm Division Of De Pharmascience Inc	2002-02-08	2016-10-25	Canada
Extra Strength Nighttime Cold Relief PE	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Vita Health Products Inc	2010-03-31	2014-07-28	Canada
Extra Strength Nighttime Cold Relief-caplet	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Ksl Pharmaceuticals	1995-12-31	2002-07-31	Canada
Extra Strength Nighttime Flu PE	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Vita Health Products Inc	2010-03-31	2014-07-28	Canada
Extra Strength Tylenol Allergy	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2006-07-24	2016-01-22	Canada
Extra Strength Tylenol Allergy Sinus Caplets	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1993-12-31	2016-01-22	Canada
Extra Strength Tylenol Cold & Sinus Nighttime	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2010-08-11	Not applicable	Canada
Extra Strength Tylenol Cold and Flu Powder	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder, for solution	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1991-12-31	2004-07-22	Canada
Extra Strength Tylenol Cold Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2006-07-24	Not applicable	Canada
Extra Strength Tylenol Cold Nighttime Caplet	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1987-12-31	2016-08-05	Canada
Extra Strength Tylenol Complete Cold, Cough & Flu Plus Mucus Relief Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Guaifenesin Pseudoephedrine	Syrup	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2011-08-08	Not applicable	Canada
Extra Strength Tylenol Flu Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2006-07-24	Not applicable	Canada
Extra Strength Tylenol Sinus Nighttime	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2006-07-24	Not applicable	Canada
Extra Strength Tylenol Sinus Pain and Congestion Nighttime	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2005-08-23	2016-01-22	Canada
Family Wellness Effervescent Cold Relief Orange	Acetylsalicylic acid Chlorphenamine Phenylephrine	Tablet, effervescent	Oral	Family Dollar Services	2011-09-15	Not applicable	US
Family Wellness Effervescent Cold Relief Original	Acetylsalicylic acid Chlorphenamine Phenylephrine	Tablet, effervescent	Oral	Family Dollar Services	2011-09-15	Not applicable	US
Flu BP Maximum Strength	Acetaminophen Chlorphenamine Dextromethorphan	Tablet, film coated	Oral	L&R Distributors, Inc.	2005-06-01	Not applicable	US
Flu HBP	Acetaminophen Chlorphenamine Dextromethorphan	Tablet, film coated	Oral	Cvs Health	2005-06-01	Not applicable	US
Flu HBP Maximum Strength	Acetaminophen Chlorphenamine Dextromethorphan	Tablet, film coated	Oral	Cardinal Health	2005-06-01	Not applicable	US
Flu HBP Maxium Strength	Acetaminophen Chlorphenamine Dextromethorphan	Tablet, film coated	Oral	Chain Drug Marketing Association	2005-06-01	Not applicable	US
Flu Multi Symptom Relief	Acetaminophen Acetaminophen Chlorphenamine Dextromethorphan Dextromethorphan Phenylephrine Phenylephrine	Kit; Tablet	Oral	Vita Health Products Inc	Not applicable	Not applicable	Canada
Flu Relief Childrens	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Topcare (Topco Associates Llc)	2015-07-31	Not applicable	US
Fluact	Chlorphenamine Phenylephrine	Capsule	Oral	Pharmaline Incorporated	Not applicable	Not applicable	Canada
Formule 115 DM	Chlorphenamine Dextromethorphan Pseudoephedrine	Syrup	Oral	Frega Inc.	1982-12-31	2007-07-09	Canada
Fulton Street Market Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Access Business Group	2010-08-11	Not applicable	US
Ganmaoling 999	Acetaminophen Caffeine Chlorphenamine	Granule	Oral	Kingsway Trading	2012-06-30	Not applicable	US
Gencontuss	Chlorphenamine Dextromethorphan Phenylephrine	Solution	Oral	Kramer Novis.	2015-06-08	Not applicable	US
Good Neighbor Pharmacy Allergy Multi Symptom	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Amerisource Bergen	2006-12-12	Not applicable	US
Good Neighbor Pharmacy Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Amerisource Bergen	2008-10-06	Not applicable	US
Good Neighbor Pharmacy Cold and Allergy PE	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Amerisource Bergen	2006-11-21	Not applicable	US
Good Neighbor Pharmacy Cold Head Congestion	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Amerisource Bergen	2007-07-19	Not applicable	US
Good Neighbor Pharmacy Cold Plus Multi Symptom	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Amerisource Bergen	2008-09-02	Not applicable	US
Good Neighbor Pharmacy Sinus	Acetaminophen Chlorphenamine Phenylephrine	Kit		Amerisource Bergen	2008-09-02	Not applicable	US
Good Neighbor Pharmacy Sinus and Allergy PE	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Amerisource Bergen	2006-11-20	Not applicable	US
Good Neighbor Pharmacy Sinus Congestion and Pain	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Amerisource Bergen	2008-08-25	Not applicable	US
Good Sense Allergy Multi Symptom	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	L. Perrigo Company	2005-10-06	Not applicable	US
Good Sense Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	L. Perrigo Company	2010-09-01	Not applicable	US
Good Sense Cold and Allergy	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	L. Perrigo Company	2006-10-11	Not applicable	US
Good Sense Sinus and Allergy PE	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	L. Perrigo Company	2006-11-28	Not applicable	US
Grippalin & C Tab	Acetaminophen Chlorphenamine Vitamin C	Tablet	Oral	Distributions Multi Pro Inc.	1988-12-31	2000-08-02	Canada
Grippe Extra Fort Nuit	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Therapharma Inc.	Not applicable	Not applicable	Canada
Hanshinnocol	Acetaminophen Chlorphenamine Dextromethorphan	Liquid	Oral	Han Kook Shin Yak Pharmaceutical Co., Ltd.	2015-06-30	Not applicable	US
Head Congestion	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Meijer Distribution	2009-08-05	Not applicable	US
Head Congestion Cold Relief	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Woonsocket Prescription Center, Incorporated	2005-07-21	Not applicable	US
Head Congestion Daytime and Nighttime Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Supervalu	2005-07-21	Not applicable	US
Healthy Accents Allergy Multi Symptom	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Dza Brands,	2008-04-01	Not applicable	US
Healthy Accents Childrens Multi Symptom Fever and Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Dza Brands,	2015-10-22	Not applicable	US
Healthy Accents Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Dza Brands,	2008-03-10	Not applicable	US
Healthy Accents Cold Head Congestion	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Dza Brands,	2008-02-04	Not applicable	US
Healthy Accents Multi Symptom Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Dza Brands,	2011-06-06	Not applicable	US
Healthy Accents Sinus	Acetaminophen Chlorphenamine Phenylephrine	Kit		Dza Brands,	2008-03-10	Not applicable	US
High Blood Pressure Cold and Flu	Acetaminophen Chlorphenamine	Tablet, coated	Oral	Bedrock Brands, Llc	2005-05-31	Not applicable	US
Hot Lemon Night Time Total Extra Strength	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Hot Lemon Relief for Sore Throat and Cough Extra Strength	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder	Oral	Jamp Pharma Corporation	Not applicable	Not applicable	Canada
Hot Lemon Relief for Symptoms Of Cough, Cold and Flu	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder	Oral	Patheon Laboratories	Not applicable	Not applicable	Canada
Hot Lemon Relief for Symptoms Of Cough, Cold and Flu Extra Strength	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder	Oral	Pharmetics (2011) Inc.	2004-02-13	Not applicable	Canada
hybrid CF	Acetaminophen Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Hybrid Rx Llc	2010-02-03	Not applicable	US
Hydrocodone Bitartrate and Chlorpheniramine Maleate	Chlorphenamine Hydrocodone	Solution	Oral	Acella Pharmaceuticals, LLC	2017-06-14	Not applicable	US
Hydrocodone Bitartrate and Chlorpheniramine Maleate Solution	Chlorphenamine Hydrocodone	Solution	Oral	Tris Pharma, Inc.	2015-03-01	2016-11-30	US
Hydrocodone Bitartrate Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride	Chlorphenamine Hydrocodone Pseudoephedrine	Solution	Oral	Bio Pharm, Inc.	2017-05-16	Not applicable	US
Hydrocodone Bitartrate, Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride	Chlorphenamine Hydrocodone Pseudoephedrine	Solution	Oral	Paddock Laboratories, Inc.	2014-08-26	Not applicable	US
Hydrocodone Bitartrate, Chlorpheniramine Maleate, and Pseudoephedrine HCl	Chlorphenamine Hydrocodone Pseudoephedrine	Solution	Oral	Cypress Pharmaceuticals, Inc.	2014-01-09	Not applicable	US
Hydrocodone Bitartrate, Chlorpheniramine Maleate, and Pseudoephedrine Hydrochloride Oral Solution	Chlorphenamine Hydrocodone Pseudoephedrine	Solution	Oral	Tris Pharma, Inc.	2015-01-04	2016-11-30	US
Hydrocodone Polistirex and Chlorpheniramine Polisitrex	Chlorphenamine Hydrocodone	Suspension, extended release	Oral	Atlantic Biologicals Corps.	2012-08-16	Not applicable	US
Hydrocodone Polistirex and Chlorpheniramine Polistirex	Chlorphenamine Hydrocodone	Suspension, extended release	Oral	Neos Therapeutics, Lp	2014-10-23	Not applicable	US
Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended-Release	Chlorphenamine Hydrocodone	Suspension, extended release	Oral	Aristos Phamaceuticals, Inc.	2012-06-29	2016-10-13	US
Hydrocodone Polistirex and Chlorpheniramine Polistirex Pennkinetic	Chlorphenamine Hydrocodone	Suspension, extended release	Oral	Kremers Urban	1987-12-31	Not applicable	US
Infants Tylenol Cold Suspension Drops	Acetaminophen Chlorphenamine Pseudoephedrine	Suspension	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1997-08-11	2007-11-05	Canada
Jack & Jill Children's Formula Cough Liquid	Chlorphenamine Dextromethorphan	Liquid	Oral	The Buckley's Company	1990-12-31	2016-08-02	Canada
Jack & Jill Complete	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Syrup	Oral	The Buckley's Company	Not applicable	Not applicable	Canada
Jack & Jill Cough and Cold	Chlorphenamine Dextromethorphan Pseudoephedrine	Liquid	Oral	The Buckley's Company	2001-09-04	2013-09-04	Canada
Jack & Jill Cough, Cold & Flu Junior Strength Tablets	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	The Buckley's Company	2001-10-12	2011-07-26	Canada
Junior Strength Cold DM - Tablet	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Vita Health Products Inc	1996-10-11	2009-08-06	Canada
Junior Strength Tylenol Cold and Cough	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet, chewable	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1991-12-31	2016-01-22	Canada
Junior Strength Tylenol Complete Cold, Cough & Fever	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet, chewable	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2011-10-19	2016-01-22	Canada
Kgs Allergy Soothing	Acetaminophen Chlorphenamine	Capsule, delayed release pellets	Oral	Kingsway	2014-01-30	Not applicable	US
Kidkare cough/cold	Chlorphenamine Dextromethorphan Pseudoephedrine	Liquid	Oral	Rugby	2011-01-13	Not applicable	US
Kirkland Signature Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Costco Wholesale	2010-12-02	Not applicable	US
Leader Allergy Multi Symptom	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Cardinal Health	2006-01-18	Not applicable	US
Leader Cold and Allergy	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Cardinal Health	2006-11-22	Not applicable	US
Leader Cold Head Congestion	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Cardinal Health	2007-11-15	Not applicable	US
Leader Sinus and Allergy PE	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Cardinal Health	2006-10-19	Not applicable	US
Lexuss 210	Chlorphenamine Codeine	Liquid	Oral	Centurion Labs	2009-04-15	2017-08-17	US
Lil Drug Store Allergy Sinus Relief	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Lil' Drug Store Products, Inc.	2011-02-08	Not applicable	US
LoHist D	Chlorphenamine Pseudoephedrine	Liquid	Oral	Larken Laboratories, Inc.	2003-09-15	Not applicable	US
M-end DM	Chlorphenamine Dextromethorphan Pseudoephedrine	Liquid	Oral	R. A. Mc Neil Company	2008-11-13	2017-02-07	US
Madame Pearl's Cough Syrup	Chlorphenamine Dextromethorphan Ephedrine Guaifenesin	Syrup	Oral	Wing Quon Enterprises Ltd.	Not applicable	Not applicable	Canada
Maux De Gorge Et De LA Toux Extra-fort	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder	Oral	Pharmalab Inc.	Not applicable	Not applicable	Canada
Maximum Strength Allergy Sinus	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Walgreen	1999-10-01	Not applicable	US
Maximum Strength Flu	Acetaminophen Chlorphenamine Dextromethorphan	Tablet, film coated	Oral	Rite Aid	2005-06-01	Not applicable	US
Maximum Strength Flu HBP	Acetaminophen Chlorphenamine Dextromethorphan	Tablet, film coated	Oral	Dolgencorp	2005-06-01	2016-02-18	US
Medicament Pour Le Rhume, Nuit	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Laboratoire Riva Inc	Not applicable	Not applicable	Canada
Medique Medicidin D	Acetaminophen Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Unifirst First Aid	2008-12-30	Not applicable	US
Medique Onset Forte	Acetaminophen Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Unifirst First Aid	2008-12-30	2016-01-01	US
Members Mark Allergy	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Sam's West, Inc	2006-08-15	Not applicable	US
Metreton Tab	Chlorphenamine Prednisone Vitamin C	Tablet	Oral	Schering Plough	1956-12-31	2007-08-03	Canada
Multi Symptom Cold Childrens	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Kroger	2008-08-11	Not applicable	US
Multi Symptom Cold Childrens Plus	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Quality Choice (Chain Drug Marketing Association, Inc.)	2015-09-30	Not applicable	US
Multi Symptom Cold Plus Childrens	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Western Family Foods	2008-12-10	Not applicable	US
Multi Symptom Cold Plus Childrens Pain Relief	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Hyvee	2008-08-25	Not applicable	US
Multi Symptom Cold Relief Childrens	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Cvs Health	2009-03-11	Not applicable	US
Multi Symptom Fever and Cold Childrens	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Hyvee	2015-09-16	Not applicable	US
Multi Sympton Cold Day Night	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Kareway Product, Inc.	2012-05-01	Not applicable	US
Multi-Symptom Allergy	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Walgreen	2008-03-17	Not applicable	US
Multi-Symptom Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Value Merchandisers	2005-07-21	Not applicable	US
Multi-Symptom Cold Relief	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Capsule, liquid filled	Oral	Woonsocket Prescription Center, Incorporated	2008-03-29	2015-12-29	US
Multi-Symptom Cold Relief Daytime, Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Target Corporation.	2005-07-21	2018-11-04	US
Nasal + Sinus Cold Formula	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Vita Health Products Inc	1999-06-24	2010-07-14	Canada
Neo DM DROPS DM	Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Laser Pharmaceuticals Llc	2006-10-06	Not applicable	US
Neo Tuss Syr	Chlorphenamine Dextromethorphan Guaifenesin Phenylephrine Sodium Citrate	Syrup	Oral	Neolab Inc	1979-12-31	2007-07-27	Canada
Neocitran Cough & Cold Syrup	Chlorphenamine Dextromethorphan Pseudoephedrine	Syrup	Oral	Novartis	2004-07-30	2007-07-18	Canada
Neocitran Ultra Strength Total Flu Night	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder	Oral	Glaxosmithkline Inc	1998-08-28	Not applicable	Canada
Night Time Cold Multi-Symptom	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Dolgencorp	2005-07-21	Not applicable	US
Night Time Sinus Congestion and Pain	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Kroger	2011-07-31	Not applicable	US
Night Time Total Extra Strength	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder	Oral	Pharmetics (2011) Inc.	2010-12-08	Not applicable	Canada
Nighttime Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Publix Supermarkets, Inc.	2007-12-03	Not applicable	US
Nighttime Cold and Flu Relief Alcohol Free	Acetaminophen Chlorphenamine Dextromethorphan	Liquid	Oral	Cvs Health	2016-07-05	Not applicable	US
Nighttime Cold Head Congestion	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Fred's	2005-07-21	2017-09-29	US
Nighttime Cold Relief Extra Strength Tablets	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Pharmetics (2011) Inc.	2004-08-25	Not applicable	Canada
Nighttime Cold Relief Extra Strength Tablets PE	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Nighttime Extra Strength Contac Cold & Sore Throat	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Valeant Canada Lp Valeant Canada S.E.C.	2007-07-03	Not applicable	Canada
Nighttime Extra Strength Contac Complete Cough, Cold & Flu	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Valeant Canada Lp Valeant Canada S.E.C.	2006-08-31	Not applicable	Canada
Nighttime Extra Strength Contac Complete Cough, Cold & Flu Plus Vitamin C	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine Vitamin C	Tablet	Oral	Glaxosmithkline Inc	Not applicable	Not applicable	Canada
Nighttime Multi-Symptom Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Capsule	Oral	Walgreen	2005-07-21	Not applicable	US
Nighttime Regular Strength Contac Cold Nasal Congestion	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Glaxosmithkline Inc	2006-08-31	2008-08-01	Canada
Nighttime Total Super Strength	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder, for solution	Oral	The Winning Combination Inc.	Not applicable	Not applicable	Canada
Nite Time (children's)	Chlorphenamine Dextromethorphan Pseudoephedrine	Liquid	Oral	Perrigo International	1999-06-18	2007-04-16	Canada
Nitetime Cold Relief Extra Strength	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Jamp Pharma Corporation	Not applicable	Not applicable	Canada
NoHist DM	Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Larken Laboratories, Inc.	2011-01-06	Not applicable	US
NoHist LQ	Chlorphenamine Phenylephrine	Liquid	Oral	Larken Laboratories, Inc.	2011-01-06	Not applicable	US
Norel AD	Acetaminophen Chlorphenamine Phenylephrine	Tablet, multilayer	Oral	Us Pharmaceutical Corporation	2012-04-27	Not applicable	US
NorelCS CS	Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Us Pharmaceutical Corporation	2012-08-01	Not applicable	US
Once-A-day Benylin Cold Cap	Chlorphenamine Pseudoephedrine	Capsule, extended release	Oral	Kv Pharmaceutical Company	1990-12-31	2002-04-29	Canada
Ornade AF Liquid	Chlorphenamine Phenylpropanolamine	Liquid	Oral	Smithkline Beecham Pharma Division Of Smithkline Beecham Inc	1993-12-31	1997-08-15	Canada
Ornade AF Spansule Src	Chlorphenamine Phenylpropanolamine	Capsule, extended release	Oral	Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.	1965-12-31	2000-11-06	Canada
Ornade DM 10 Liq	Chlorphenamine Dextromethorphan Phenylpropanolamine	Liquid	Oral	Smithkline Beecham Pharma Division Of Smithkline Beecham Inc	1993-12-31	1997-08-15	Canada
Ornade DM 15 Liq	Chlorphenamine Dextromethorphan Phenylpropanolamine	Liquid	Oral	Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.	1965-12-31	1997-08-15	Canada
Ornade DM 30 Liq	Chlorphenamine Dextromethorphan Phenylpropanolamine	Liquid	Oral	Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.	1994-12-31	1997-08-15	Canada
Ornade Expectorant Cough Formula	Chlorphenamine Guaifenesin Phenylpropanolamine	Liquid	Oral	Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.	1994-12-31	1997-08-15	Canada
Ornade Liquid	Chlorphenamine Phenylpropanolamine	Liquid	Oral	Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.	1965-12-31	1997-08-15	Canada
Ornade Spansule Src	Chlorphenamine Phenylpropanolamine	Capsule, extended release	Oral	Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.	1995-12-31	2000-11-06	Canada
Otis Clapp Valihist	Acetaminophen Chlorphenamine Phenylephrine	Tablet, coated	Oral	Unifirst First Aid	2012-03-19	Not applicable	US
Pain & Fever + Cold	Acetaminophen Chlorphenamine Pseudoephedrine	Suspension	Oral	Accudial Pharmaceutical, Inc.	2012-10-01	Not applicable	Canada
Pain & Fever + Cold & Cough	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Suspension	Oral	Accudial Pharmaceutical, Inc.	2012-10-01	Not applicable	Canada
Pain Relief Plus	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Meijer Distribution	2008-08-01	Not applicable	US
Pain Reliever Fever Reducer	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, effervescent	Oral	Velocity Pharma	2014-08-15	Not applicable	US
Panto A	Acetaminophen Chlorphenamine Guaifenesin	Liquid	Oral	SAMSUNG PHARM IND. CO., LTD.	2012-03-01	2017-04-14	US
Panto Flu	Chlorphenamine Dextromethorphan	Powder	Oral	SAMSUNG PHARM IND. CO., LTD.	2012-12-01	2017-04-14	US
Pedia Relief	Chlorphenamine Dextromethorphan Pseudoephedrine	Liquid	Oral	Major	1997-01-05	Not applicable	US
PediaCare Childrens Plus Cough and Runny Nose	Acetaminophen Chlorphenamine Dextromethorphan	Liquid	Oral	Blacksmith Brands, Inc.	2010-07-09	Not applicable	US
PediaCare Childrens Plus Flu	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Prestige Brands Holdings, Inc.	2010-07-09	2017-07-01	US
PediaCare Childrens Plus Multisymptom Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Prestige Brands Holdings, Inc.	2010-07-09	2018-02-28	US
PediaCare Multi Symptom Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Strides Pharma Inc	2010-07-09	Not applicable	US
PediaCare Plus Multisymptom Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	MOBERG PHARMA NORTH AMERICA LLC	2010-07-09	Not applicable	US
Pediacare-Cough-RunnyNose	Acetaminophen Chlorphenamine Dextromethorphan	Liquid	Oral	Strides Pharma Inc	2010-07-09	Not applicable	US
Pediatric Cough and Cold Medicine	Chlorphenamine Dextromethorphan Pseudoephedrine	Liquid	Oral	Silarx Pharmaceuticals, Inc.	1997-01-05	Not applicable	US
Pentuss Srs	Chlorphenamine Codeine	Syrup	Oral	Rhone Poulenc Rorer	1984-12-31	1999-08-12	Canada
Phenylhistine DH	Chlorphenamine Codeine Pseudoephedrine	Liquid	Oral	Qualitest	1996-10-01	2018-04-30	US
Physicians Care Allergy Plus	Acetaminophen Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Acme United Corporation	2011-12-23	Not applicable	US
PhysiciansCare Allergy Multi-Symptom Relief	Acetaminophen Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Acme United Corporation	2011-12-23	Not applicable	US
Plus Multi Symptom Cold Childrens Pain Relief	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Hannaford Brothers Company	2008-10-29	Not applicable	US
Poly Hist Pd	Chlorphenamine Mepyramine Phenylephrine	Liquid	Oral	Poly Pharmaceuticals	2004-08-05	2017-08-29	US
Poly-tussin DM	Chlorphenamine Dextromethorphan Phenylephrine	Syrup	Oral	Poly Pharmaceuticals	2005-10-21	2016-12-31	US
Prime's Sore Throat, Cough and Colds Capsules	Acetaminophen Chlorphenamine Dextromethorphan Guaifenesin Pseudoephedrine	Capsule	Oral	Prime Packaging, Inc.	Not applicable	Not applicable	Canada
Pseudoephedrine Plus	Chlorphenamine Pseudoephedrine	Tablet	Oral	Contract Pharmacal Corporation	2001-02-20	Not applicable	US
Quality Choice Effervescent Cold Relief Plus	Acetylsalicylic acid Chlorphenamine Phenylephrine	Tablet, effervescent	Oral	Chain Drug Marketing Association	2014-01-01	Not applicable	US
R-Tanna	Chlorphenamine Phenylephrine	Tablet	Oral	Pd Rx Pharmaceuticals, Inc.	2005-10-19	2016-12-21	US
R-Tanna Pediatric Suspension	Chlorphenamine Phenylephrine	Suspension	Oral	Prasco, Laboratories	2010-02-03	2016-10-13	US
Rapid Release Multi-Symptom Allergy Relief	Acetaminophen Chlorphenamine Phenylephrine	Capsule, gelatin coated	Oral	Walmart Stores	2008-03-17	Not applicable	US
Reg.str.cold Medic.(night Time Relief)caplet	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Westcan Pharmaceuticals Ltd.	1995-12-31	2002-07-31	Canada
Regular Strength Tylenol Cold and Flu Powder	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder, for solution	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1991-12-31	2000-07-24	Canada
Regular Strength Tylenol Cold Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2006-07-24	Not applicable	Canada
Regular Strength Tylenol Cold Nighttime Caplet	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1987-12-31	2016-08-05	Canada
Relief-PE	Acetaminophen Chlorphenamine Phenylephrine	Tablet, coated	Oral	Nor Med	2012-04-16	Not applicable	US
Relievol Allergy Sinus Caplets Extra Strength	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Tanta Pharmaceuticals Inc	2000-05-29	Not applicable	Canada
Rescon DM	Chlorphenamine Dextromethorphan Pseudoephedrine	Liquid	Oral	Capellon Pharmaceuticals, LLC	1999-01-01	Not applicable	US
Rhume Extra Fort Nuit	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Therapharma Inc.	Not applicable	Not applicable	Canada
Robitussin Peak Cold Nighttime Nasal Relief	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Richmond Division of Wyeth	2011-06-06	Not applicable	US
Robitussin Total Cough, Cold & Flu Extra Strength	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Liquid	Oral	Pfizer Laboratories Div Pfizer Inc.	2008-08-20	Not applicable	Canada
Rx Act sinus and allergy PE	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	H.E.B.	2010-05-21	Not applicable	US
Rycontuss Cherry Flavor	Chlorphenamine Dextromethorphan Phenylephrine	Liquid	Oral	Okendpharma, Inc.	2011-05-31	Not applicable	US
Sanaflu Xtra	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Capsule, gelatin coated	Oral	Grandall Distributing Co., Inc.	2015-04-30	Not applicable	US
SanaTos COLD Multi-Symptom	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Pharmadel LLC	2013-03-25	2017-01-18	US
Scot-Tussin DM Maximum Strength Cough Suppressant and Cold Relief	Chlorphenamine Dextromethorphan	Liquid	Oral	Iri Sys, Llc	2016-01-01	Not applicable	US
Scot-Tussin DM SF Maximum Strength Cough Cold	Chlorphenamine Dextromethorphan	Liquid	Oral	Scot Tussin Pharmacal Co., Inc.	1983-09-28	Not applicable	US
ShopRite Allergy	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Wakfern Food Corporation	2013-07-17	Not applicable	US
ShopRite Childrens Multi Symptom Cold Relief	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Wakfern Food Corporation	2013-08-14	Not applicable	US
Sildec PE DM	Chlorphenamine Dextromethorphan Phenylephrine	Syrup	Oral	Rebel Distributors	2010-03-31	Not applicable	US
Sine Off Sinus/cold Medicine	Acetaminophen Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Gemini Pharmaceuticals, Inc.	2010-07-05	Not applicable	US
Sine-off Allergy Tab	Acetaminophen Chlorphenamine Phenylpropanolamine	Tablet	Oral	Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.	1993-12-31	2000-11-06	Canada
Sinus	Acetaminophen Chlorphenamine Phenylephrine	Kit		Hyvee	2007-10-01	Not applicable	US
Sinus and Allergy	Chlorphenamine Phenylephrine	Tablet	Oral	Topcare (Topco Associates Llc)	2014-05-30	Not applicable	US
Sinus and Allergy Maximum Strength	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Western Family Foods	2007-03-30	Not applicable	US
Sinus and Allergy PE	Chlorphenamine Phenylephrine	Tablet	Oral	Better Living Brands	2005-06-09	2016-05-09	US
Sinus and Allergy PE Maximum Strength	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Kroger	2007-04-06	Not applicable	US
Sinus and Allergy Regular Strength	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Sinus and Allergy Releif PE	Chlorphenamine Phenylephrine	Tablet	Oral	P And L Development Of New York Corporation (Ready In Case)	2014-02-28	Not applicable	US
Sinus and Allergy Relief	Chlorphenamine Phenylephrine	Tablet	Oral	Better Living Brands	2005-06-09	Not applicable	US
Sinus and Allergy Relief PE	Chlorphenamine Phenylephrine	Tablet	Oral	Rite Aid	2005-06-09	Not applicable	US
Sinus Congestion and Pain	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Meijer Distribution	2007-08-31	Not applicable	US
Sinus Congestion and Pain Daytime Nighttime	Acetaminophen Chlorphenamine Phenylephrine	Kit		AAA Pharmaceutical, Inc.	2012-12-28	Not applicable	US
Sinus Congestion and Pain Daytime/Nighttime	Acetaminophen Chlorphenamine Phenylephrine	Kit		Walgreen	2005-07-26	2019-08-08	US
Sinus Congestion and Pain Nighttime	Acetaminophen Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Fred's	2005-06-28	Not applicable	US
Sinus Extra Fort Nuit	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Therapharma Inc.	Not applicable	Not applicable	Canada
Sinus Nighttime Extra Strength Caplets	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Sinus Pain and Congestion	Acetaminophen Chlorphenamine Phenylephrine	Kit		Cvs Health	2005-07-26	Not applicable	US
Sinus Pain and Congestion Nighttime	Acetaminophen Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Cvs Health	2005-06-28	2019-07-08	US
Sinus PE plus Allergy Maximum Strength	Chlorphenamine Phenylephrine	Tablet	Oral	Cvs Health	2005-06-09	Not applicable	US
sinus plus allergy PE maximum strength	Chlorphenamine Phenylephrine	Tablet	Oral	Supervalu	2005-06-09	Not applicable	US
Sinus plus Headache Daytime and Nighttime	Acetaminophen Chlorphenamine Phenylephrine	Kit		Good Sense	2011-12-31	Not applicable	US
Sinus Relief	Acetaminophen Chlorphenamine Phenylephrine	Kit		Western Family Foods	2007-06-05	Not applicable	US
Sinus Relief Congestion and Pain - Daytime and Nighttime	Acetaminophen Chlorphenamine Phenylephrine	Kit		Amerisource Bergen	2011-10-28	Not applicable	US
Sinus Relief Congestion and Pain Nighttime	Acetaminophen Chlorphenamine Phenylephrine	Tablet, coated	Oral	Amerisource Bergen	2011-10-28	Not applicable	US
Sinus Ultra Strength Tablet	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Jamp Pharma Corporation	2005-01-31	2008-09-28	Canada
Sinusales Extra Fort Nuit	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Prodemdis Enr.	Not applicable	Not applicable	Canada
Sinutab Extra Strength Tablets	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1986-12-31	Not applicable	Canada
Sinutab PE Extra Strength	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Sinutab PE Nightime	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Sinutab Regular Strength Tablets	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1991-12-31	2017-01-27	Canada
Sinutab With Codeine Tablets	Acetaminophen Chlorphenamine Codeine Pseudoephedrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1991-12-31	2015-08-06	Canada
Smart Sense Childrens Multi Symptom Cold Relief	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Kmart Corporation	2014-02-27	Not applicable	US
Smart Sense Multi Symptom Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Kmart Corporation	2010-12-29	Not applicable	US
Smart Sense Multi Symptom Fever and Cold Childrens	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Kmart Corporation	2015-10-23	Not applicable	US
Smart Sense sinus plus headache	Acetaminophen Chlorphenamine Phenylephrine	Kit		Kmart Corporation	2017-06-05	Not applicable	US
SohMed Allergy Sinus	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	SOHM Inc.	2013-08-25	Not applicable	US
Sore Throat & Cough Ultra Strength	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder, for solution	Oral	Pharmascience Inc	2001-03-01	2016-10-28	Canada
Stona	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Sato Pharmaceutical	2004-09-29	Not applicable	US
Stona for Children	Acetaminophen Chlorphenamine Dextromethorphan	Syrup	Oral	Sato Pharmaceutical	2001-01-03	Not applicable	US
Stona-S	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Capsule	Oral	Sato Pharmaceutical	2004-09-27	Not applicable	US
Stonarhini	Chlorphenamine Phenylephrine	Tablet	Oral	Sato Pharmaceutical	2001-11-16	Not applicable	US
Sudafed Sinus & Allergy	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Sudafed Sinus Complete	Acetaminophen Chlorphenamine Pseudoephedrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
SudoGest	Chlorphenamine Pseudoephedrine	Tablet	Oral	Major	1992-12-16	Not applicable	US
Sunmark Allergy Multi Symptom	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Mc Kesson	2005-12-06	Not applicable	US
sunmark Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Mc Kesson	2009-04-01	Not applicable	US
Sunmark Cold and Allergy	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Mc Kesson	2006-09-22	Not applicable	US
Sunmark Sinus and Allergy PE Maximum Strength	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Mc Kesson	2006-09-25	Not applicable	US
Suphedrine PE	Chlorphenamine Phenylephrine	Tablet	Oral	Walmart Stores	2005-06-09	Not applicable	US
Suphedrine PE Sinus plus Allergy	Chlorphenamine Phenylephrine	Tablet	Oral	Army + Air Force Exchange Service	2005-06-09	Not applicable	US
Tabcin 500	Acetylsalicylic acid Chlorphenamine Phenylephrine	Tablet, effervescent	Oral	Salimex, S.A.	2013-08-21	Not applicable	US
Theraflu Flu Cold and Cough Medicine	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder	Oral	Sandoz	1992-12-31	1998-08-12	Canada
Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, coated	Oral	Novartis	2009-09-02	2017-04-14	US
Top Value Effervescent Cold Relief	Acetylsalicylic acid Chlorphenamine Phenylephrine	Tablet, effervescent	Oral	Tower Laboratories Ltd	2010-07-01	Not applicable	US
Topcare Allergy Multi Symptom	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Topco Associates	2005-12-09	Not applicable	US
Topcare Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Topco Associates	2008-01-18	2016-11-08	US
Topcare Cold and Allergy	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Topco Associates	2006-09-12	Not applicable	US
Topcare Cold Head Congestion Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Topco Associates	2007-07-19	Not applicable	US
TopCare Cold NightTime Multi Symptom	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet, film coated	Oral	Topco Associates	2007-12-04	Not applicable	US
TopCare Sinus and Allergy PE Maximum Strength	Chlorphenamine Phenylephrine	Tablet, film coated	Oral	Topco Associates	2006-09-29	Not applicable	US
Topcare Sinus Congestion and Pain	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Topco Associates	2009-03-23	Not applicable	US
Total Flu	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine Vitamin C	Powder, for solution	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Toux Rhume Et Grippe (extra-fort)	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Powder	Oral	Prodemdis Enr.	Not applicable	Not applicable	Canada
Triaminic Childrens Cold and Allergy	Chlorphenamine Phenylephrine	Syrup	Oral	Novartis	2008-09-26	2016-10-13	US
Triaminic Cold & Nighttime Cough	Chlorphenamine Dextromethorphan Pseudoephedrine	Syrup	Oral	Novartis	1991-12-31	2016-08-02	Canada
Triaminic Cold and Allergy	Chlorphenamine Pseudoephedrine	Syrup	Oral	Novartis	2001-07-16	2010-06-21	Canada
Triaminic Cold and Allergy Syrup	Chlorphenamine Phenylpropanolamine	Syrup	Oral	Novartis	1991-12-31	2001-04-06	Canada
Triaminic Cold and Cough	Chlorphenamine Dextromethorphan Pseudoephedrine	Syrup	Oral	Novartis	2001-07-21	2016-08-02	Canada
Triaminic Cold Cough and Fever	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Liquid	Oral	Novartis	1999-08-03	2016-08-02	Canada
Triaminic DM Expectorant Syr	Chlorphenamine Dextromethorphan Guaifenesin Pseudoephedrine	Syrup	Oral	Novartis	1995-12-31	2001-07-30	Canada
Triaminic Expectorant Syr	Chlorphenamine Guaifenesin Pseudoephedrine	Syrup	Oral	Novartis	1995-12-31	2001-07-30	Canada
Triaminic Multi-Symptom Fever	Acetaminophen Chlorphenamine Dextromethorphan	Syrup	Oral	Novartis	2012-09-27	2016-10-13	US
Triaminic Multi-Symptom Fever and Cold	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Suspension	Oral	Glaxo Smith Kline Consumer Healthcare Holdings (Us) Llc	2013-09-30	Not applicable	US
Triaminic Softchews Cold and Allergy	Chlorphenamine Pseudoephedrine	Tablet	Oral	Novartis	2000-08-23	2016-08-02	Canada
Triaminic Softchews Cough and Cold	Chlorphenamine Dextromethorphan Pseudoephedrine	Tablet	Oral	Novartis	2000-08-23	2016-08-02	Canada
Triaminic Total Cold With Cough & Fever Relief	Acetaminophen Chlorphenamine Dextromethorphan	Liquid	Oral	Novartis	Not applicable	Not applicable	Canada
Triaminicol DM Syrup	Chlorphenamine Dextromethorphan Pseudoephedrine	Syrup	Oral	Novartis	1995-12-31	2001-07-30	Canada
Tricode AR	Chlorphenamine Codeine Pseudoephedrine	Liquid	Oral	Respa Pharmaceuticals	2011-06-20	Not applicable	US
TussiCaps	Chlorphenamine Hydrocodone	Capsule, extended release	Oral	ECR Pharmaceuticals Co., Inc.	2011-09-02	Not applicable	US
Tussilyn DM	Chlorphenamine Dextromethorphan Pseudoephedrine	Syrup	Oral	Les Laboratoires Vachon Inc.	1982-12-31	2007-07-12	Canada
Tussionex Pennkinetic	Chlorphenamine Hydrocodone	Suspension, extended release	Oral	Unither Pharmaceuticals	1987-12-31	Not applicable	US
Tuzistra XR	Chlorphenamine Codeine	Suspension, extended release	Oral	Vernalis Therapeutics, Inc.	2015-05-31	Not applicable	US
Tylenol Allergy	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Tylenol Cold Nightime Rapid Release	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2009-08-04	2016-08-05	Canada
Tylenol Cold Plus Flu Severe Day/night	Acetaminophen Chlorphenamine Dextromethorphan Guaifenesin Phenylephrine	Kit		Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	2016-07-18	Not applicable	US
Tylenol Complete Cold, Cough & Flu Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Capsule	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Tylenol Flu Nighttime	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Tylenol Sinus Nighttime	Acetaminophen Chlorphenamine Phenylephrine	Tablet	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Up and Up Cold Relief	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Kit		Target Corporation.	2009-07-31	Not applicable	US
Vasofrinic	Chlorphenamine Pseudoephedrine	Tablet	Oral	Laboratoires Trianon Inc	1972-12-31	2017-03-10	Canada
Vasofrinic Dh	Chlorphenamine Hydrocodone Pseudoephedrine	Syrup	Oral	Laboratoires Trianon Inc	1979-12-31	2017-03-10	Canada
Vasofrinic Plus Sirop	Chlorphenamine Dextromethorphan Guaifenesin Pseudoephedrine	Syrup	Oral	Laboratoires Trianon Inc	1972-12-31	2017-03-10	Canada
Vasofrinic Sirop	Chlorphenamine Pseudoephedrine	Syrup	Oral	Laboratoires Trianon Inc	1973-12-31	2017-03-10	Canada
Vicks Alcohol Free NyQuil Cold and Flu Nighttime Relief	Acetaminophen Chlorphenamine Dextromethorphan	Liquid	Oral	Procter And Gamble	2010-06-01	Not applicable	US
Vicks Children's Nyquil Cold & Cough Multi-symptom Relief	Chlorphenamine Dextromethorphan	Liquid	Oral	Procter And Gamble	2006-07-21	Not applicable	Canada
Vicks Childrens NyQuil Cold and Cough Multi-Symptom Relief	Chlorphenamine Dextromethorphan	Solution	Oral	Procter And Gamble	2011-06-22	Not applicable	US
Vicks Custom Care Cough & Cold PM	Acetaminophen Chlorphenamine Dextromethorphan	Liquid	Oral	Procter And Gamble	2009-07-23	Not applicable	Canada
Vicks Formula 44 Nighttime Cough and Cold	Acetaminophen Chlorphenamine Dextromethorphan	Liquid	Oral	Procter And Gamble	2017-07-11	Not applicable	US
Vicks Formula 44m Liq	Acetaminophen Chlorphenamine Dextromethorphan Pseudoephedrine	Liquid	Oral	Procter And Gamble	1992-12-31	Not applicable	Canada
Vicks NyQuil Cold and Flu Nighttime Relief and Vicks Childrens NyQuil Cold and Cough	Acetaminophen Chlorphenamine Dextromethorphan Doxylamine	Kit		Procter And Gamble	2012-07-23	2016-11-01	US
Vicks Pediatric Formula 44m Liq	Chlorphenamine Dextromethorphan Pseudoephedrine	Liquid	Oral	Procter And Gamble	1992-12-31	Not applicable	Canada
Vituz	Chlorphenamine Hydrocodone	Solution	Oral	Hawthorn Pharmaceuticals, Inc.	2013-04-01	Not applicable	US
Wal-Finate D	Chlorphenamine Pseudoephedrine	Tablet	Oral	Walgreen	2001-05-21	Not applicable	US
Wal-phed	Chlorphenamine Pseudoephedrine	Tablet	Oral	Walgreen	1992-12-16	Not applicable	US
Wal-Phed PE Maximum Strength	Chlorphenamine Phenylephrine	Tablet	Oral	Walgreen	2005-06-09	Not applicable	US
WinCo Foods Effervescent Cold Relief	Acetylsalicylic acid Chlorphenamine Phenylephrine	Tablet, effervescent	Oral	Win Co Foods, Llc,	2015-01-01	Not applicable	US
Xl3 Xtra	Acetaminophen Chlorphenamine Dextromethorphan Phenylephrine	Capsule, liquid filled	Oral	Teresa Cecena Dba Genesis	2015-08-07	Not applicable	US
Yinchiao	Acetaminophen Chlorphenamine	Tablet, coated	Oral	Tianjin Zhongxin Pharmaceutical Group Corp Ltd Longshunrong Pharmaceutical Factory	2001-07-17	Not applicable	US
Z-tuss Ac	Chlorphenamine Codeine	Liquid	Oral	Magna Pharmaceuticals	2011-01-11	2017-02-07	US
Zodryl AC 25	Chlorphenamine Codeine	Suspension	Oral	Coda Dose, Inc.	2009-08-24	Not applicable	US
Zodryl AC 30	Chlorphenamine Codeine	Suspension	Oral	Coda Dose, Inc.	2009-08-24	Not applicable	US
Zodryl AC 40	Chlorphenamine Codeine	Suspension	Oral	Coda Dose, Inc.	2009-08-24	Not applicable	US
Zodryl AC 50	Chlorphenamine Codeine	Suspension	Oral	Coda Dose, Inc.	2009-08-24	Not applicable	US
Zodryl AC 60	Chlorphenamine Codeine	Suspension	Oral	Coda Dose, Inc.	2009-08-24	Not applicable	US
Zodryl AC 80	Chlorphenamine Codeine	Suspension	Oral	Coda Dose, Inc.	2009-08-24	Not applicable	US
Zutripro	Chlorphenamine Hydrocodone Pseudoephedrine	Solution	Oral	Hawthorn Pharmaceuticals, Inc.	2011-06-08	Not applicable	US

Categories

UNII

3U6IO1965U

CAS number

132-22-9

Weight

Average: 274.788
Monoisotopic: 274.123676325

Chemical Formula

C₁₆H₁₉ClN₂

InChI Key

SOYKEARSMXGVTM-UHFFFAOYSA-N

InChI

InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3

IUPAC Name

[3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl]dimethylamine

SMILES

CN(C)CCC(C1=CC=C(Cl)C=C1)C1=CC=CC=N1

Pharmacology

Indication

For the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.

Structured Indications

Pharmacodynamics

In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H₁-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H₁-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

Mechanism of action

Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

Target	Kind	Pharmacological action	Actions	Organism	UniProt ID
Histamine H1 receptor	Protein	yes	antagonist	Human	P35367	details
Sodium-dependent serotonin transporter	Protein	unknown	inhibitor	Human	P31645	details
Sodium-dependent noradrenaline transporter	Protein	unknown	inhibitor	Human	P23975	details
Sodium-dependent dopamine transporter	Protein	unknown	inhibitor	Human	Q01959	details

Absorption

Well absorbed in the gastrointestinal tract.

Volume of distribution

Not Available

Protein binding

72%

Metabolism

Primarily hepatic via Cytochrome P450 (CYP450) enzymes.

Route of elimination

Not Available

Half life

21-27 hours

Clearance

Not Available

Toxicity

Oral LD50 (rat): 306 mg/kg; Oral LD50 (mice): 130 mg/kg; Oral LD50 (guinea pig): 198 mg/kg [Registry of Toxic Effects of Chemical Substances. Ed. D. Sweet, US Dept. of Health & Human Services: Cincinatti, 2010.] Also a mild reproductive toxin to women of childbearing age.

Affected organisms

Humans and other mammals

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

Drug	Interaction	Drug group
2,5-Dimethoxy-4-ethylamphetamine	2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Chlorphenamine.	Experimental, Illicit
3,4-Methylenedioxyamphetamine	3,4-Methylenedioxyamphetamine may decrease the sedative activities of Chlorphenamine.	Experimental, Illicit
3,4-Methylenedioxymethamphetamine	3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Chlorphenamine.	Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine	4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Chlorphenamine.	Experimental, Illicit
7-Nitroindazole	The risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Chlorphenamine.	Experimental
Abiraterone	The serum concentration of Chlorphenamine can be increased when it is combined with Abiraterone.	Approved
Acepromazine	The risk or severity of adverse effects can be increased when Acepromazine is combined with Chlorphenamine.	Approved, Vet Approved
Aceprometazine	The risk or severity of adverse effects can be increased when Aceprometazine is combined with Chlorphenamine.	Approved
Adipiplon	The risk or severity of adverse effects can be increased when adipiplon is combined with Chlorphenamine.	Investigational
Agomelatine	The risk or severity of adverse effects can be increased when Agomelatine is combined with Chlorphenamine.	Approved, Investigational
Alfaxalone	The risk or severity of adverse effects can be increased when Alfaxalone is combined with Chlorphenamine.	Vet Approved
Alfentanil	The risk or severity of adverse effects can be increased when Alfentanil is combined with Chlorphenamine.	Approved, Illicit
Allopregnanolone	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Sage 547.	Investigational
Alphacetylmethadol	The risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Chlorphenamine.	Experimental, Illicit
Alprazolam	The risk or severity of adverse effects can be increased when Alprazolam is combined with Chlorphenamine.	Approved, Illicit, Investigational
Amiodarone	The metabolism of Chlorphenamine can be decreased when combined with Amiodarone.	Approved, Investigational
Amisulpride	The risk or severity of adverse effects can be increased when Amisulpride is combined with Chlorphenamine.	Approved, Investigational
Amitriptyline	The risk or severity of adverse effects can be increased when Amitriptyline is combined with Chlorphenamine.	Approved
Amobarbital	The risk or severity of adverse effects can be increased when Amobarbital is combined with Chlorphenamine.	Approved, Illicit
Amoxapine	The risk or severity of adverse effects can be increased when Amoxapine is combined with Chlorphenamine.	Approved
Amperozide	The risk or severity of adverse effects can be increased when Amperozide is combined with Chlorphenamine.	Experimental
Amphetamine	Amphetamine may decrease the sedative activities of Chlorphenamine.	Approved, Illicit
Aprepitant	The serum concentration of Chlorphenamine can be increased when it is combined with Aprepitant.	Approved, Investigational
Aripiprazole	The serum concentration of Aripiprazole can be increased when it is combined with Chlorphenamine.	Approved, Investigational
Artemether	The metabolism of Chlorphenamine can be decreased when combined with Artemether.	Approved
Articaine	The risk or severity of adverse effects can be increased when Articaine is combined with Chlorphenamine.	Approved
Asenapine	The risk or severity of adverse effects can be increased when Asenapine is combined with Chlorphenamine.	Approved
Atazanavir	The metabolism of Chlorphenamine can be decreased when combined with Atazanavir.	Approved, Investigational
Atomoxetine	The metabolism of Chlorphenamine can be decreased when combined with Atomoxetine.	Approved
Azaperone	The risk or severity of adverse effects can be increased when Azaperone is combined with Chlorphenamine.	Vet Approved
Azelastine	Chlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.	Approved
Azelastine	The risk or severity of adverse effects can be increased when Azelastine is combined with Chlorphenamine.	Approved
Baclofen	The risk or severity of adverse effects can be increased when Baclofen is combined with Chlorphenamine.	Approved
Barbital	The risk or severity of adverse effects can be increased when Barbital is combined with Chlorphenamine.	Illicit
Benperidol	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Benperidol.	Investigational
Benzocaine	The risk or severity of adverse effects can be increased when Benzocaine is combined with Chlorphenamine.	Approved
Benzphetamine	Benzphetamine may decrease the sedative activities of Chlorphenamine.	Approved, Illicit
Benzyl alcohol	The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Chlorphenamine.	Approved
Benzylpenicilloyl Polylysine	Chlorphenamine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.	Approved
Betahistine	The therapeutic efficacy of Betahistine can be decreased when used in combination with Chlorphenamine.	Approved
Betaxolol	The metabolism of Chlorphenamine can be decreased when combined with Betaxolol.	Approved
Bexarotene	The serum concentration of Chlorphenamine can be decreased when it is combined with Bexarotene.	Approved, Investigational
Boceprevir	The metabolism of Chlorphenamine can be decreased when combined with Boceprevir.	Withdrawn
Bortezomib	The metabolism of Chlorphenamine can be decreased when combined with Bortezomib.	Approved, Investigational
Bosentan	The serum concentration of Chlorphenamine can be decreased when it is combined with Bosentan.	Approved, Investigational
Brexpiprazole	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Brexpiprazole.	Approved
Brimonidine	The risk or severity of adverse effects can be increased when Brimonidine is combined with Chlorphenamine.	Approved
Brimonidine	Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.	Approved
Bromazepam	The risk or severity of adverse effects can be increased when Bromazepam is combined with Chlorphenamine.	Approved, Illicit
Brompheniramine	The risk or severity of adverse effects can be increased when Brompheniramine is combined with Chlorphenamine.	Approved
Brotizolam	The risk or severity of adverse effects can be increased when Brotizolam is combined with Chlorphenamine.	Approved, Withdrawn
Bupivacaine	The risk or severity of adverse effects can be increased when Bupivacaine is combined with Chlorphenamine.	Approved, Investigational
Buprenorphine	Chlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.	Approved, Illicit, Investigational, Vet Approved
Bupropion	The metabolism of Chlorphenamine can be decreased when combined with Bupropion.	Approved
Buspirone	The risk or severity of adverse effects can be increased when Buspirone is combined with Chlorphenamine.	Approved, Investigational
Butabarbital	The risk or severity of adverse effects can be increased when Butabarbital is combined with Chlorphenamine.	Approved, Illicit
Butacaine	The risk or severity of adverse effects can be increased when Butacaine is combined with Chlorphenamine.	Vet Approved
Butalbital	The risk or severity of adverse effects can be increased when Butalbital is combined with Chlorphenamine.	Approved, Illicit
Butamben	The risk or severity of adverse effects can be increased when Butamben is combined with Chlorphenamine.	Approved
Butethal	The risk or severity of adverse effects can be increased when Butethal is combined with Chlorphenamine.	Approved, Illicit
Butorphanol	The risk or severity of adverse effects can be increased when Butorphanol is combined with Chlorphenamine.	Approved, Illicit, Vet Approved
Carbamazepine	The metabolism of Chlorphenamine can be increased when combined with Carbamazepine.	Approved, Investigational
Carbinoxamine	The risk or severity of adverse effects can be increased when Carbinoxamine is combined with Chlorphenamine.	Approved
Carfentanil	The risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorphenamine.	Illicit, Vet Approved
Carisoprodol	The risk or severity of adverse effects can be increased when Carisoprodol is combined with Chlorphenamine.	Approved
Celecoxib	The metabolism of Chlorphenamine can be decreased when combined with Celecoxib.	Approved, Investigational
Ceritinib	The serum concentration of Chlorphenamine can be increased when it is combined with Ceritinib.	Approved
Cetirizine	The risk or severity of adverse effects can be increased when Cetirizine is combined with Chlorphenamine.	Approved
Chloral hydrate	The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Chlorphenamine.	Approved, Illicit, Vet Approved
Chlordiazepoxide	The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chlorphenamine.	Approved, Illicit
Chlormezanone	The risk or severity of adverse effects can be increased when Chlormezanone is combined with Chlorphenamine.	Approved, Withdrawn
Chloroprocaine	The risk or severity of adverse effects can be increased when Chloroprocaine is combined with Chlorphenamine.	Approved
Chloroquine	The metabolism of Chlorphenamine can be decreased when combined with Chloroquine.	Approved, Vet Approved
Chlorphentermine	Chlorphentermine may decrease the sedative activities of Chlorphenamine.	Illicit, Withdrawn
Chlorpromazine	The metabolism of Chlorphenamine can be decreased when combined with Chlorpromazine.	Approved, Vet Approved
Chlorprothixene	The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Chlorphenamine.	Approved, Withdrawn
Chlorzoxazone	The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Chlorphenamine.	Approved
Cholecalciferol	The metabolism of Chlorphenamine can be decreased when combined with Cholecalciferol.	Approved, Nutraceutical
Cimetidine	The metabolism of Chlorphenamine can be decreased when combined with Cimetidine.	Approved
Cinacalcet	The metabolism of Chlorphenamine can be decreased when combined with Cinacalcet.	Approved
Cinchocaine	The risk or severity of adverse effects can be increased when Cinchocaine is combined with Chlorphenamine.	Approved, Vet Approved
Citalopram	The metabolism of Chlorphenamine can be decreased when combined with Citalopram.	Approved
Clarithromycin	The metabolism of Chlorphenamine can be decreased when combined with Clarithromycin.	Approved
Clemastine	The metabolism of Chlorphenamine can be decreased when combined with Clemastine.	Approved
Clidinium	The risk or severity of adverse effects can be increased when Clidinium is combined with Chlorphenamine.	Approved
Clobazam	The metabolism of Chlorphenamine can be decreased when combined with Clobazam.	Approved, Illicit
clomethiazole	The risk or severity of adverse effects can be increased when clomethiazole is combined with Chlorphenamine.	Investigational
Clomipramine	The metabolism of Chlorphenamine can be decreased when combined with Clomipramine.	Approved, Vet Approved
Clonazepam	The risk or severity of adverse effects can be increased when Clonazepam is combined with Chlorphenamine.	Approved, Illicit
Clonidine	The risk or severity of adverse effects can be increased when Clonidine is combined with Chlorphenamine.	Approved
Clorazepate	The risk or severity of adverse effects can be increased when Clorazepate is combined with Chlorphenamine.	Approved, Illicit
Clotrimazole	The metabolism of Chlorphenamine can be decreased when combined with Clotrimazole.	Approved, Vet Approved
Clozapine	The metabolism of Chlorphenamine can be decreased when combined with Clozapine.	Approved
Cobicistat	The serum concentration of Chlorphenamine can be increased when it is combined with Cobicistat.	Approved
Cocaine	The metabolism of Chlorphenamine can be decreased when combined with Cocaine.	Approved, Illicit
Codeine	The risk or severity of adverse effects can be increased when Codeine is combined with Chlorphenamine.	Approved, Illicit
Conivaptan	The serum concentration of Chlorphenamine can be increased when it is combined with Conivaptan.	Approved, Investigational
Crizotinib	The metabolism of Chlorphenamine can be decreased when combined with Crizotinib.	Approved
Cyclizine	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Cyclizine.	Approved
Cyclobenzaprine	The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Chlorphenamine.	Approved
Cyclosporine	The metabolism of Chlorphenamine can be decreased when combined with Cyclosporine.	Approved, Investigational, Vet Approved
Cyproheptadine	The risk or severity of adverse effects can be increased when Cyproheptadine is combined with Chlorphenamine.	Approved
Dabrafenib	The serum concentration of Chlorphenamine can be decreased when it is combined with Dabrafenib.	Approved
Dantrolene	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Dantrolene.	Approved
Dapiprazole	The risk or severity of adverse effects can be increased when Dapiprazole is combined with Chlorphenamine.	Approved
Dapoxetine	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Dapoxetine.	Investigational
Darifenacin	The metabolism of Chlorphenamine can be decreased when combined with Darifenacin.	Approved, Investigational
Darunavir	The serum concentration of Chlorphenamine can be increased when it is combined with Darunavir.	Approved
Dasatinib	The serum concentration of Chlorphenamine can be increased when it is combined with Dasatinib.	Approved, Investigational
Deferasirox	The serum concentration of Chlorphenamine can be decreased when it is combined with Deferasirox.	Approved, Investigational
Delavirdine	The metabolism of Chlorphenamine can be decreased when combined with Delavirdine.	Approved
Deramciclane	The risk or severity of adverse effects can be increased when deramciclane is combined with Chlorphenamine.	Investigational
Desflurane	The risk or severity of adverse effects can be increased when Desflurane is combined with Chlorphenamine.	Approved
Desipramine	The metabolism of Chlorphenamine can be decreased when combined with Desipramine.	Approved
Desloratadine	The risk or severity of adverse effects can be increased when Desloratadine is combined with Chlorphenamine.	Approved, Investigational
Desvenlafaxine	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Desvenlafaxine.	Approved
Detomidine	The risk or severity of adverse effects can be increased when Detomidine is combined with Chlorphenamine.	Vet Approved
Dexamethasone	The serum concentration of Chlorphenamine can be decreased when it is combined with Dexamethasone.	Approved, Investigational, Vet Approved
Dexbrompheniramine	The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Chlorphenamine.	Approved
Dexmedetomidine	The risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Chlorphenamine.	Approved, Vet Approved
Dextroamphetamine	Dextroamphetamine may decrease the sedative activities of Chlorphenamine.	Approved, Illicit
Dextromoramide	The risk or severity of adverse effects can be increased when Dextromoramide is combined with Chlorphenamine.	Experimental, Illicit
Dextropropoxyphene	The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Chlorphenamine.	Approved, Illicit, Withdrawn
Dezocine	The risk or severity of adverse effects can be increased when Dezocine is combined with Chlorphenamine.	Approved
Diazepam	The risk or severity of adverse effects can be increased when Diazepam is combined with Chlorphenamine.	Approved, Illicit, Vet Approved
Diethylpropion	Diethylpropion may decrease the sedative activities of Chlorphenamine.	Approved, Illicit
Difenoxin	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Difenoxin.	Approved, Illicit
Dihydrocodeine	The risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Chlorphenamine.	Approved, Illicit
Dihydroergotamine	The metabolism of Chlorphenamine can be decreased when combined with Dihydroergotamine.	Approved
Dihydroetorphine	The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Chlorphenamine.	Experimental, Illicit
Dihydromorphine	The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Chlorphenamine.	Experimental, Illicit
Diltiazem	The metabolism of Chlorphenamine can be decreased when combined with Diltiazem.	Approved
Dimenhydrinate	The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Chlorphenamine.	Approved
Diphenhydramine	The metabolism of Chlorphenamine can be decreased when combined with Diphenhydramine.	Approved
Diphenoxylate	The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Chlorphenamine.	Approved, Illicit
Doramectin	The risk or severity of adverse effects can be increased when Doramectin is combined with Chlorphenamine.	Vet Approved
Doxepin	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Doxepin.	Approved
Doxycycline	The metabolism of Chlorphenamine can be decreased when combined with Doxycycline.	Approved, Investigational, Vet Approved
Doxylamine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.	Approved, Vet Approved
DPDPE	The risk or severity of adverse effects can be increased when DPDPE is combined with Chlorphenamine.	Investigational
Dronabinol	Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.	Approved, Illicit
Dronedarone	The metabolism of Chlorphenamine can be decreased when combined with Dronedarone.	Approved
Droperidol	Droperidol may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.	Approved, Vet Approved
Drotebanol	The risk or severity of adverse effects can be increased when Drotebanol is combined with Chlorphenamine.	Experimental, Illicit
Duloxetine	The metabolism of Chlorphenamine can be decreased when combined with Duloxetine.	Approved
Dyclonine	The risk or severity of adverse effects can be increased when Dyclonine is combined with Chlorphenamine.	Approved
Ecgonine	The risk or severity of adverse effects can be increased when Ecgonine is combined with Chlorphenamine.	Experimental, Illicit
Ecopipam	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Ecopipam.	Investigational
Efavirenz	The serum concentration of Chlorphenamine can be decreased when it is combined with Efavirenz.	Approved, Investigational
Eliglustat	The metabolism of Chlorphenamine can be decreased when combined with Eliglustat.	Approved
Eltanolone	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Pregnanolone.	Investigational
Enflurane	The risk or severity of adverse effects can be increased when Enflurane is combined with Chlorphenamine.	Approved, Vet Approved
Entacapone	The risk or severity of adverse effects can be increased when Entacapone is combined with Chlorphenamine.	Approved, Investigational
Enzalutamide	The serum concentration of Chlorphenamine can be decreased when it is combined with Enzalutamide.	Approved
Erythromycin	The metabolism of Chlorphenamine can be decreased when combined with Erythromycin.	Approved, Vet Approved
Escitalopram	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Escitalopram.	Approved, Investigational
Eslicarbazepine acetate	The serum concentration of Chlorphenamine can be decreased when it is combined with Eslicarbazepine acetate.	Approved
Estazolam	The risk or severity of adverse effects can be increased when Estazolam is combined with Chlorphenamine.	Approved, Illicit
Eszopiclone	The risk or severity of adverse effects can be increased when Eszopiclone is combined with Chlorphenamine.	Approved
Ethanol	Chlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.	Approved
Ethchlorvynol	The risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Chlorphenamine.	Approved, Illicit, Withdrawn
Ethosuximide	The risk or severity of adverse effects can be increased when Ethosuximide is combined with Chlorphenamine.	Approved
Ethotoin	The risk or severity of adverse effects can be increased when Ethotoin is combined with Chlorphenamine.	Approved
Ethyl carbamate	The risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Chlorphenamine.	Withdrawn
Ethyl loflazepate	The risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Chlorphenamine.	Approved, Illicit
Ethylmorphine	The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Chlorphenamine.	Approved, Illicit
Etidocaine	The risk or severity of adverse effects can be increased when Etidocaine is combined with Chlorphenamine.	Approved
Etifoxine	The risk or severity of adverse effects can be increased when Etifoxine is combined with Chlorphenamine.	Withdrawn
Etizolam	The risk or severity of adverse effects can be increased when Etizolam is combined with Chlorphenamine.	Approved
Etomidate	The risk or severity of adverse effects can be increased when Etomidate is combined with Chlorphenamine.	Approved
Etoperidone	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Etoperidone.	Approved
Etorphine	The risk or severity of adverse effects can be increased when Etorphine is combined with Chlorphenamine.	Illicit, Vet Approved
Etravirine	The serum concentration of Chlorphenamine can be decreased when it is combined with Etravirine.	Approved
Ezogabine	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Ezogabine.	Approved
Felbamate	The risk or severity of adverse effects can be increased when Felbamate is combined with Chlorphenamine.	Approved
Fencamfamine	The risk or severity of adverse effects can be increased when Fencamfamine is combined with Chlorphenamine.	Approved, Illicit, Withdrawn
Fentanyl	The risk or severity of adverse effects can be increased when Fentanyl is combined with Chlorphenamine.	Approved, Illicit, Investigational, Vet Approved
Fesoterodine	The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Chlorphenamine.	Approved
Fexofenadine	The risk or severity of adverse effects can be increased when Fexofenadine is combined with Chlorphenamine.	Approved
Flibanserin	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Flibanserin.	Approved
Fluconazole	The metabolism of Chlorphenamine can be decreased when combined with Fluconazole.	Approved
Fludiazepam	The risk or severity of adverse effects can be increased when Fludiazepam is combined with Chlorphenamine.	Approved, Illicit
Flunarizine	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Flunarizine.	Approved
Flunitrazepam	The risk or severity of adverse effects can be increased when Flunitrazepam is combined with Chlorphenamine.	Approved, Illicit
Fluoxetine	The metabolism of Chlorphenamine can be decreased when combined with Fluoxetine.	Approved, Vet Approved
Flupentixol	The risk or severity of adverse effects can be increased when Flupentixol is combined with Chlorphenamine.	Approved, Withdrawn
Fluphenazine	The risk or severity of adverse effects can be increased when Fluphenazine is combined with Chlorphenamine.	Approved
Flurazepam	The risk or severity of adverse effects can be increased when Flurazepam is combined with Chlorphenamine.	Approved, Illicit
Fluspirilene	The risk or severity of adverse effects can be increased when Fluspirilene is combined with Chlorphenamine.	Approved
Fluticasone propionate	The risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Chlorphenamine.	Approved
Fluvoxamine	The metabolism of Chlorphenamine can be decreased when combined with Fluvoxamine.	Approved, Investigational
Fosamprenavir	The metabolism of Chlorphenamine can be decreased when combined with Fosamprenavir.	Approved
Fosaprepitant	The serum concentration of Chlorphenamine can be increased when it is combined with Fosaprepitant.	Approved
Fosphenytoin	The serum concentration of Fosphenytoin can be increased when it is combined with Chlorphenamine.	Approved
Fospropofol	The risk or severity of adverse effects can be increased when Fospropofol is combined with Chlorphenamine.	Approved, Illicit
Fusidic Acid	The serum concentration of Chlorphenamine can be increased when it is combined with Fusidic Acid.	Approved
Gabapentin	The risk or severity of adverse effects can be increased when Gabapentin is combined with Chlorphenamine.	Approved, Investigational
Gabapentin Enacarbil	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with gabapentin enacarbil.	Approved
Gamma Hydroxybutyric Acid	The risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Chlorphenamine.	Approved, Illicit
Gepirone	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Gepirone.	Investigational
Glutethimide	The risk or severity of adverse effects can be increased when Glutethimide is combined with Chlorphenamine.	Approved, Illicit
Guanfacine	The risk or severity of adverse effects can be increased when Guanfacine is combined with Chlorphenamine.	Approved, Investigational
Halazepam	The risk or severity of adverse effects can be increased when Halazepam is combined with Chlorphenamine.	Approved, Illicit, Withdrawn
Haloperidol	The metabolism of Chlorphenamine can be decreased when combined with Haloperidol.	Approved
Halothane	The risk or severity of adverse effects can be increased when Halothane is combined with Chlorphenamine.	Approved, Vet Approved
Heroin	The risk or severity of adverse effects can be increased when Heroin is combined with Chlorphenamine.	Approved, Illicit
Hexobarbital	The risk or severity of adverse effects can be increased when Hexobarbital is combined with Chlorphenamine.	Approved
Hyaluronidase	The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Chlorphenamine.	Approved, Investigational
Hydrocodone	Chlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.	Approved, Illicit
Hydromorphone	The risk or severity of adverse effects can be increased when Hydromorphone is combined with Chlorphenamine.	Approved, Illicit
Hydroxyamphetamine	Hydroxyamphetamine hydrobromide may decrease the sedative activities of Chlorphenamine.	Approved
Hydroxyzine	Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.	Approved
Idelalisib	The serum concentration of Chlorphenamine can be increased when it is combined with Idelalisib.	Approved
Iloperidone	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Iloperidone.	Approved
Imatinib	The metabolism of Chlorphenamine can be decreased when combined with Imatinib.	Approved
Imipramine	The metabolism of Chlorphenamine can be decreased when combined with Imipramine.	Approved
Indalpine	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Indalpine.	Investigational, Withdrawn
Indinavir	The metabolism of Chlorphenamine can be decreased when combined with Indinavir.	Approved
Isavuconazonium	The metabolism of Chlorphenamine can be decreased when combined with Isavuconazonium.	Approved, Investigational
Isoflurane	The risk or severity of adverse effects can be increased when Isoflurane is combined with Chlorphenamine.	Approved, Vet Approved
Isoniazid	The metabolism of Chlorphenamine can be decreased when combined with Isoniazid.	Approved
Isradipine	The metabolism of Chlorphenamine can be decreased when combined with Isradipine.	Approved
Itraconazole	The metabolism of Chlorphenamine can be decreased when combined with Itraconazole.	Approved, Investigational
Ivacaftor	The serum concentration of Chlorphenamine can be increased when it is combined with Ivacaftor.	Approved
Ketamine	The risk or severity of adverse effects can be increased when Ketamine is combined with Chlorphenamine.	Approved, Vet Approved
Ketazolam	The risk or severity of adverse effects can be increased when Ketazolam is combined with Chlorphenamine.	Approved
Ketobemidone	The risk or severity of adverse effects can be increased when Ketobemidone is combined with Chlorphenamine.	Approved
Ketoconazole	The metabolism of Chlorphenamine can be decreased when combined with Ketoconazole.	Approved, Investigational
Lamotrigine	The risk or severity of adverse effects can be increased when Lamotrigine is combined with Chlorphenamine.	Approved, Investigational
Levetiracetam	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Levetiracetam.	Approved, Investigational
Levobupivacaine	The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Chlorphenamine.	Approved
Levocabastine	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Levocabastine.	Approved
Levocetirizine	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Levocetirizine.	Approved
Levodopa	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Levodopa.	Approved
Levomethadyl Acetate	The risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Chlorphenamine.	Approved
Levomilnacipran	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Levomilnacipran.	Approved
Levorphanol	The risk or severity of adverse effects can be increased when Levorphanol is combined with Chlorphenamine.	Approved
Lidocaine	The risk or severity of adverse effects can be increased when Lidocaine is combined with Chlorphenamine.	Approved, Vet Approved
Lisdexamfetamine	Lisdexamfetamine may decrease the sedative activities of Chlorphenamine.	Approved, Investigational
Lithium	The risk or severity of adverse effects can be increased when Lithium is combined with Chlorphenamine.	Approved
Lofentanil	The risk or severity of adverse effects can be increased when Lofentanil is combined with Chlorphenamine.	Illicit
Lopinavir	The metabolism of Chlorphenamine can be decreased when combined with Lopinavir.	Approved
Loratadine	The risk or severity of adverse effects can be increased when Loratadine is combined with Chlorphenamine.	Approved
Lorazepam	The risk or severity of adverse effects can be increased when Lorazepam is combined with Chlorphenamine.	Approved
Lorcaserin	The metabolism of Chlorphenamine can be decreased when combined with Lorcaserin.	Approved
Lovastatin	The metabolism of Chlorphenamine can be decreased when combined with Lovastatin.	Approved, Investigational
Loxapine	The risk or severity of adverse effects can be increased when Loxapine is combined with Chlorphenamine.	Approved
Luliconazole	The serum concentration of Chlorphenamine can be increased when it is combined with Luliconazole.	Approved
Lumacaftor	The metabolism of Chlorphenamine can be increased when combined with Lumacaftor.	Approved
Lumefantrine	The metabolism of Chlorphenamine can be decreased when combined with Lumefantrine.	Approved
Lurasidone	The risk or severity of adverse effects can be increased when Lurasidone is combined with Chlorphenamine.	Approved
Magnesium Sulfate	Magnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.	Approved, Vet Approved
Maprotiline	The risk or severity of adverse effects can be increased when Maprotiline is combined with Chlorphenamine.	Approved
Meclizine	The risk or severity of adverse effects can be increased when Meclizine is combined with Chlorphenamine.	Approved
Medetomidine	The risk or severity of adverse effects can be increased when Medetomidine is combined with Chlorphenamine.	Vet Approved
Melatonin	The risk or severity of adverse effects can be increased when Melatonin is combined with Chlorphenamine.	Approved, Nutraceutical, Vet Approved
Melperone	The risk or severity of adverse effects can be increased when Melperone is combined with Chlorphenamine.	Approved
Mephedrone	Mephedrone may decrease the sedative activities of Chlorphenamine.	Investigational
Mephentermine	Mephentermine may decrease the sedative activities of Chlorphenamine.	Approved
Mepivacaine	The risk or severity of adverse effects can be increased when Mepivacaine is combined with Chlorphenamine.	Approved, Vet Approved
Meprobamate	The risk or severity of adverse effects can be increased when Meprobamate is combined with Chlorphenamine.	Approved, Illicit
Mesoridazine	The risk or severity of adverse effects can be increased when Mesoridazine is combined with Chlorphenamine.	Approved
Metaxalone	The risk or severity of adverse effects can be increased when Metaxalone is combined with Chlorphenamine.	Approved
Methadone	The metabolism of Chlorphenamine can be decreased when combined with Methadone.	Approved
Methadyl Acetate	The risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chlorphenamine.	Approved, Illicit
Methamphetamine	Methamphetamine may decrease the sedative activities of Chlorphenamine.	Approved, Illicit
Methapyrilene	The risk or severity of adverse effects can be increased when Methapyrilene is combined with Chlorphenamine.	Withdrawn
Methaqualone	The risk or severity of adverse effects can be increased when Methaqualone is combined with Chlorphenamine.	Illicit, Withdrawn
Methocarbamol	The risk or severity of adverse effects can be increased when Methocarbamol is combined with Chlorphenamine.	Approved, Vet Approved
Methohexital	The risk or severity of adverse effects can be increased when Methohexital is combined with Chlorphenamine.	Approved
Methotrimeprazine	Chlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.	Approved
Methoxyflurane	The risk or severity of adverse effects can be increased when Methoxyflurane is combined with Chlorphenamine.	Approved, Vet Approved
Methsuximide	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Methsuximide.	Approved
Methylecgonine	The risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Chlorphenamine.	Experimental
Methylphenobarbital	The risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Chlorphenamine.	Approved
Metoprolol	The serum concentration of Metoprolol can be increased when it is combined with Chlorphenamine.	Approved, Investigational
Metyrosine	Chlorphenamine may increase the sedative activities of Metyrosine.	Approved
Midazolam	The risk or severity of adverse effects can be increased when Midazolam is combined with Chlorphenamine.	Approved, Illicit
Mifepristone	The serum concentration of Chlorphenamine can be increased when it is combined with Mifepristone.	Approved, Investigational
Milnacipran	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Milnacipran.	Approved
Minocycline	Minocycline may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.	Approved, Investigational
Mirabegron	The metabolism of Chlorphenamine can be decreased when combined with Mirabegron.	Approved
Mirtazapine	Chlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.	Approved
Mitotane	The serum concentration of Chlorphenamine can be decreased when it is combined with Mitotane.	Approved
MMDA	MMDA may decrease the sedative activities of Chlorphenamine.	Experimental, Illicit
Modafinil	The serum concentration of Chlorphenamine can be decreased when it is combined with Modafinil.	Approved, Investigational
Molindone	The risk or severity of adverse effects can be increased when Molindone is combined with Chlorphenamine.	Approved
Morphine	The risk or severity of adverse effects can be increased when Morphine is combined with Chlorphenamine.	Approved, Investigational
Nabilone	Nabilone may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.	Approved, Investigational
Nafcillin	The serum concentration of Chlorphenamine can be decreased when it is combined with Nafcillin.	Approved
Nalbuphine	The risk or severity of adverse effects can be increased when Nalbuphine is combined with Chlorphenamine.	Approved
Nefazodone	The metabolism of Chlorphenamine can be decreased when combined with Nefazodone.	Approved, Withdrawn
Nelfinavir	The metabolism of Chlorphenamine can be decreased when combined with Nelfinavir.	Approved
Netupitant	The serum concentration of Chlorphenamine can be increased when it is combined with Netupitant.	Approved
Nevirapine	The metabolism of Chlorphenamine can be increased when combined with Nevirapine.	Approved
Nicardipine	The metabolism of Chlorphenamine can be decreased when combined with Nicardipine.	Approved
Nilotinib	The metabolism of Chlorphenamine can be decreased when combined with Nilotinib.	Approved, Investigational
Nitrazepam	The risk or severity of adverse effects can be increased when Nitrazepam is combined with Chlorphenamine.	Approved
Nitrous oxide	The risk or severity of adverse effects can be increased when Nitrous oxide is combined with Chlorphenamine.	Approved, Vet Approved
Norflurane	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with 1,1,1,2 Tetrafluoroethane.	Investigational
Normethadone	The risk or severity of adverse effects can be increased when Normethadone is combined with Chlorphenamine.	Approved, Illicit
Nortriptyline	The risk or severity of adverse effects can be increased when Nortriptyline is combined with Chlorphenamine.	Approved
Olanzapine	The risk or severity of adverse effects can be increased when Olanzapine is combined with Chlorphenamine.	Approved, Investigational
Olaparib	The metabolism of Chlorphenamine can be decreased when combined with Olaparib.	Approved
Olopatadine	The risk or severity of adverse effects can be increased when Olopatadine is combined with Chlorphenamine.	Approved
Ondansetron	The risk or severity of adverse effects can be increased when Ondansetron is combined with Chlorphenamine.	Approved
Opium	The risk or severity of adverse effects can be increased when Opium is combined with Chlorphenamine.	Approved, Illicit
Orphenadrine	Chlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.	Approved
Osanetant	The risk or severity of adverse effects can be increased when Osanetant is combined with Chlorphenamine.	Investigational
Osimertinib	The serum concentration of Chlorphenamine can be increased when it is combined with Osimertinib.	Approved
Oxazepam	The risk or severity of adverse effects can be increased when Oxazepam is combined with Chlorphenamine.	Approved
Oxethazaine	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Oxetacaine.	Investigational
Oxprenolol	The risk or severity of adverse effects can be increased when Oxprenolol is combined with Chlorphenamine.	Approved
Oxybuprocaine	The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Chlorphenamine.	Approved
Oxycodone	The risk or severity of adverse effects can be increased when Oxycodone is combined with Chlorphenamine.	Approved, Illicit, Investigational
Oxymorphone	The risk or severity of adverse effects can be increased when Oxymorphone is combined with Chlorphenamine.	Approved, Investigational, Vet Approved
Palbociclib	The serum concentration of Chlorphenamine can be increased when it is combined with Palbociclib.	Approved
Paliperidone	The risk or severity of adverse effects can be increased when Paliperidone is combined with Chlorphenamine.	Approved
Panobinostat	The serum concentration of Chlorphenamine can be increased when it is combined with Panobinostat.	Approved, Investigational
Paraldehyde	Chlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.	Approved
Paroxetine	The metabolism of Chlorphenamine can be decreased when combined with Paroxetine.	Approved, Investigational
Peginterferon alfa-2b	The serum concentration of Chlorphenamine can be decreased when it is combined with Peginterferon alfa-2b.	Approved
Pentazocine	The risk or severity of adverse effects can be increased when Pentazocine is combined with Chlorphenamine.	Approved, Vet Approved
Pentobarbital	The metabolism of Chlorphenamine can be increased when combined with Pentobarbital.	Approved, Vet Approved
Perampanel	Perampanel may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.	Approved
Perazine	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Perazine.	Investigational
Perospirone	The risk or severity of adverse effects can be increased when Perospirone is combined with Chlorphenamine.	Approved
Perphenazine	The risk or severity of adverse effects can be increased when Perphenazine is combined with Chlorphenamine.	Approved
Pethidine	The risk or severity of adverse effects can be increased when Pethidine is combined with Chlorphenamine.	Approved
Phenobarbital	The metabolism of Chlorphenamine can be increased when combined with Phenobarbital.	Approved
Phenoxyethanol	The risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Chlorphenamine.	Approved
Phentermine	Phentermine may decrease the sedative activities of Chlorphenamine.	Approved, Illicit
Phenytoin	The serum concentration of Phenytoin can be increased when it is combined with Chlorphenamine.	Approved, Vet Approved
Pimozide	The risk or severity of adverse effects can be increased when Pimozide is combined with Chlorphenamine.	Approved
Pipamperone	The risk or severity of adverse effects can be increased when Pipamperone is combined with Chlorphenamine.	Approved
Pipotiazine	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Pipotiazine.	Approved
Piritramide	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Piritramide.	Investigational
Pizotifen	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Pizotifen.	Approved
Pomalidomide	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Pomalidomide.	Approved
Posaconazole	The metabolism of Chlorphenamine can be decreased when combined with Posaconazole.	Approved, Investigational, Vet Approved
Pramipexole	Chlorphenamine may increase the sedative activities of Pramipexole.	Approved, Investigational
Pramocaine	The risk or severity of adverse effects can be increased when Pramocaine is combined with Chlorphenamine.	Approved
Prazepam	The risk or severity of adverse effects can be increased when Prazepam is combined with Chlorphenamine.	Approved, Illicit
Pregabalin	The risk or severity of adverse effects can be increased when Pregabalin is combined with Chlorphenamine.	Approved, Illicit, Investigational
Prilocaine	The risk or severity of adverse effects can be increased when Prilocaine is combined with Chlorphenamine.	Approved
Primidone	The metabolism of Chlorphenamine can be increased when combined with Primidone.	Approved, Vet Approved
Procaine	The risk or severity of adverse effects can be increased when Procaine is combined with Chlorphenamine.	Approved, Investigational, Vet Approved
Prochlorperazine	The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Chlorphenamine.	Approved, Vet Approved
Promazine	The metabolism of Chlorphenamine can be decreased when combined with Promazine.	Approved, Vet Approved
Promethazine	The risk or severity of adverse effects can be increased when Promethazine is combined with Chlorphenamine.	Approved
Proparacaine	The risk or severity of adverse effects can be increased when Proparacaine is combined with Chlorphenamine.	Approved, Vet Approved
Propofol	The risk or severity of adverse effects can be increased when Propofol is combined with Chlorphenamine.	Approved, Investigational, Vet Approved
Propoxycaine	The risk or severity of adverse effects can be increased when Propoxycaine is combined with Chlorphenamine.	Approved
Protriptyline	The risk or severity of adverse effects can be increased when Protriptyline is combined with Chlorphenamine.	Approved
PSD502	The risk or severity of adverse effects can be increased when PSD502 is combined with Chlorphenamine.	Investigational
Pseudoephedrine	Pseudoephedrine may decrease the sedative activities of Chlorphenamine.	Approved
Quazepam	The risk or severity of adverse effects can be increased when Quazepam is combined with Chlorphenamine.	Approved, Illicit
Quetiapine	The risk or severity of adverse effects can be increased when Quetiapine is combined with Chlorphenamine.	Approved
Quinidine	The metabolism of Chlorphenamine can be decreased when combined with Quinidine.	Approved
Quinine	The metabolism of Chlorphenamine can be decreased when combined with Quinine.	Approved
Raclopride	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Raclopride.	Investigational
Ramelteon	The risk or severity of adverse effects can be increased when Ramelteon is combined with Chlorphenamine.	Approved, Investigational
Ranolazine	The metabolism of Chlorphenamine can be decreased when combined with Ranolazine.	Approved, Investigational
Remifentanil	The risk or severity of adverse effects can be increased when Remifentanil is combined with Chlorphenamine.	Approved
Remoxipride	The risk or severity of adverse effects can be increased when Remoxipride is combined with Chlorphenamine.	Approved, Withdrawn
Reserpine	The risk or severity of adverse effects can be increased when Reserpine is combined with Chlorphenamine.	Approved
Rifabutin	The metabolism of Chlorphenamine can be increased when combined with Rifabutin.	Approved
Rifampicin	The metabolism of Chlorphenamine can be increased when combined with Rifampicin.	Approved
Rifapentine	The metabolism of Chlorphenamine can be increased when combined with Rifapentine.	Approved
Risperidone	The risk or severity of adverse effects can be increased when Risperidone is combined with Chlorphenamine.	Approved, Investigational
Ritanserin	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Ritanserin.	Investigational
Ritobegron	Ritobegron may decrease the sedative activities of Chlorphenamine.	Investigational
Ritonavir	The metabolism of Chlorphenamine can be decreased when combined with Ritonavir.	Approved, Investigational
Rolapitant	The metabolism of Chlorphenamine can be decreased when combined with Rolapitant.	Approved
Romifidine	The risk or severity of adverse effects can be increased when Romifidine is combined with Chlorphenamine.	Vet Approved
Ropinirole	Chlorphenamine may increase the sedative activities of Ropinirole.	Approved, Investigational
Ropivacaine	The risk or severity of adverse effects can be increased when Ropivacaine is combined with Chlorphenamine.	Approved
Rotigotine	Chlorphenamine may increase the sedative activities of Rotigotine.	Approved
Rufinamide	The risk or severity of adverse effects can be increased when Rufinamide is combined with Chlorphenamine.	Approved
Saquinavir	The metabolism of Chlorphenamine can be decreased when combined with Saquinavir.	Approved, Investigational
Scopolamine	The risk or severity of adverse effects can be increased when Scopolamine is combined with Chlorphenamine.	Approved
Secobarbital	The risk or severity of adverse effects can be increased when Secobarbital is combined with Chlorphenamine.	Approved, Vet Approved
Sepranolone	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Uc1010.	Investigational
Sertindole	The risk or severity of adverse effects can be increased when Sertindole is combined with Chlorphenamine.	Approved, Withdrawn
Sertraline	The metabolism of Chlorphenamine can be decreased when combined with Sertraline.	Approved
Sevoflurane	The risk or severity of adverse effects can be increased when Sevoflurane is combined with Chlorphenamine.	Approved, Vet Approved
Sildenafil	The metabolism of Chlorphenamine can be decreased when combined with Sildenafil.	Approved, Investigational
Siltuximab	The serum concentration of Chlorphenamine can be decreased when it is combined with Siltuximab.	Approved
Simeprevir	The serum concentration of Chlorphenamine can be increased when it is combined with Simeprevir.	Approved
Sodium oxybate	Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.	Approved
St. John's Wort	The serum concentration of Chlorphenamine can be decreased when it is combined with St. John's Wort.	Nutraceutical
Stiripentol	The serum concentration of Chlorphenamine can be increased when it is combined with Stiripentol.	Approved
Sufentanil	The risk or severity of adverse effects can be increased when Sufentanil is combined with Chlorphenamine.	Approved, Investigational
Sulfisoxazole	The metabolism of Chlorphenamine can be decreased when combined with Sulfisoxazole.	Approved, Vet Approved
Sulpiride	The risk or severity of adverse effects can be increased when Sulpiride is combined with Chlorphenamine.	Approved
Suvorexant	Chlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.	Approved
Tandospirone	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Tandospirone.	Investigational
Tapentadol	Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.	Approved
Tasimelteon	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Tasimelteon.	Approved
Telaprevir	The metabolism of Chlorphenamine can be decreased when combined with Telaprevir.	Withdrawn
Telithromycin	The metabolism of Chlorphenamine can be decreased when combined with Telithromycin.	Approved
Temazepam	The risk or severity of adverse effects can be increased when Temazepam is combined with Chlorphenamine.	Approved
Terbinafine	The metabolism of Chlorphenamine can be decreased when combined with Terbinafine.	Approved, Investigational, Vet Approved
Tetrabenazine	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Tetrabenazine.	Approved
Tetracaine	The risk or severity of adverse effects can be increased when Tetracaine is combined with Chlorphenamine.	Approved, Vet Approved
Tetrodotoxin	The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Chlorphenamine.	Investigational
Thalidomide	Chlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.	Approved, Investigational, Withdrawn
Thiamylal	The risk or severity of adverse effects can be increased when Thiamylal is combined with Chlorphenamine.	Approved, Vet Approved
Thiopental	The risk or severity of adverse effects can be increased when Thiopental is combined with Chlorphenamine.	Approved, Vet Approved
Thioridazine	Chlorphenamine may increase the arrhythmogenic activities of Thioridazine.	Withdrawn
Thiothixene	The risk or severity of adverse effects can be increased when Thiothixene is combined with Chlorphenamine.	Approved
Tiagabine	The risk or severity of adverse effects can be increased when Tiagabine is combined with Chlorphenamine.	Approved
Tiapride	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Tiapride.	Approved, Investigational
Ticlopidine	The metabolism of Chlorphenamine can be decreased when combined with Ticlopidine.	Approved
Tiletamine	The risk or severity of adverse effects can be increased when Tiletamine is combined with Chlorphenamine.	Vet Approved
Tipranavir	The metabolism of Chlorphenamine can be decreased when combined with Tipranavir.	Approved, Investigational
Tizanidine	The risk or severity of adverse effects can be increased when Tizanidine is combined with Chlorphenamine.	Approved
Tocilizumab	The serum concentration of Chlorphenamine can be decreased when it is combined with Tocilizumab.	Approved
Tolcapone	The risk or severity of adverse effects can be increased when Tolcapone is combined with Chlorphenamine.	Approved, Withdrawn
Topiramate	The risk or severity of adverse effects can be increased when Topiramate is combined with Chlorphenamine.	Approved
Tramadol	The risk or severity of adverse effects can be increased when Tramadol is combined with Chlorphenamine.	Approved, Investigational
Trans-2-Phenylcyclopropylamine	The risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Chlorphenamine.	Experimental
Tranylcypromine	The metabolism of Chlorphenamine can be decreased when combined with Tranylcypromine.	Approved
Trazodone	The risk or severity of adverse effects can be increased when Trazodone is combined with Chlorphenamine.	Approved, Investigational
Triazolam	The risk or severity of adverse effects can be increased when Triazolam is combined with Chlorphenamine.	Approved
Trifluoperazine	The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Chlorphenamine.	Approved
Triflupromazine	The risk or severity of adverse effects can be increased when Triflupromazine is combined with Chlorphenamine.	Approved, Vet Approved
Trimipramine	The risk or severity of adverse effects can be increased when Trimipramine is combined with Chlorphenamine.	Approved
Triprolidine	The risk or severity of adverse effects can be increased when Triprolidine is combined with Chlorphenamine.	Approved
Valproic Acid	The risk or severity of adverse effects can be increased when Valproic Acid is combined with Chlorphenamine.	Approved, Investigational
Venlafaxine	The metabolism of Chlorphenamine can be decreased when combined with Venlafaxine.	Approved
Verapamil	The metabolism of Chlorphenamine can be decreased when combined with Verapamil.	Approved
Vigabatrin	The risk or severity of adverse effects can be increased when Vigabatrin is combined with Chlorphenamine.	Approved
Voriconazole	The metabolism of Chlorphenamine can be decreased when combined with Voriconazole.	Approved, Investigational
Vortioxetine	The risk or severity of adverse effects can be increased when Vortioxetine is combined with Chlorphenamine.	Approved
Xylazine	The risk or severity of adverse effects can be increased when Xylazine is combined with Chlorphenamine.	Vet Approved
Zaleplon	The risk or severity of adverse effects can be increased when Zaleplon is combined with Chlorphenamine.	Approved, Illicit, Investigational
Ziconotide	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Ziconotide.	Approved
Zimelidine	The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Zimelidine.	Withdrawn
Ziprasidone	The metabolism of Chlorphenamine can be decreased when combined with Ziprasidone.	Approved
Zolazepam	The risk or severity of adverse effects can be increased when Zolazepam is combined with Chlorphenamine.	Vet Approved
Zolpidem	Chlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.	Approved
Zonisamide	The risk or severity of adverse effects can be increased when Zonisamide is combined with Chlorphenamine.	Approved, Investigational
Zopiclone	The risk or severity of adverse effects can be increased when Zopiclone is combined with Chlorphenamine.	Approved
Zotepine	The risk or severity of adverse effects can be increased when Zotepine is combined with Chlorphenamine.	Approved
Zuclopenthixol	The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Chlorphenamine.	Approved, Investigational

Food Interactions

Avoid alcohol.
Take with food.

References

Synthesis Reference

Anil M. Salpekar, John Johnson, "Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom." U.S. Patent US4631284, issued April, 1975.

US4631284

General References

MSDS [Link]

External Links

Resource	Link
Human Metabolome Database (HMDB)	HMDB01944
KEGG Drug	D07398
KEGG Compound	C06905
PubChem Compound	2725
PubChem Substance	46508253
ChemSpider	2624
BindingDB	35938
ChEBI	52010
ChEMBL	CHEMBL505
Therapeutic Targets Database	DAP000336
PharmGKB	PA448960
IUPHAR	1213
Guide to Pharmacology	1213
Drug Product Database	10259
RxList	http://www.rxlist.com/cgi/generic/chlorpheniramine.htm
Drugs.com	http://www.drugs.com/cdi/chlorpheniramine.html
Wikipedia	Chlorpheniramine

ATC Codes

R06AB54 — Chlorphenamine, combinations

R06AB04 — Chlorphenamine

AHFS Codes

04:04.20

PDB Entries

Not Available

FDA label

Not Available

MSDS

Download (72.8 KB)

Clinical Trials

Phase	Status	Purpose	Conditions	Count
1	Completed	Treatment	Healthy Volunteers	4
2	Completed	Treatment	Allergic Reactions	1
2	Terminated	Treatment	Allergic Rhinitis (AR)	1
2	Unknown Status	Treatment	Rhinitis, Seasonal, Allergic	1
3	Not Yet Recruiting	Treatment	Flu Symptoms	1
3	Unknown Status	Treatment	Acute Rhinitis / Flu-like Syndromes	1
3	Withdrawn	Treatment	Acute Rhinitis	1
4	Unknown Status	Treatment	Vitiligo	1
Not Available	Completed	Basic Science	Hypovolaemia / Temperature Change, Body	1
Not Available	Unknown Status	Prevention	Poisoning	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Amend
Anip Acquisition Co.
A-S Medication Solutions LLC
Breckenridge Pharmaceuticals
C.O. Truxton Inc.
Cardinal Health
Consolidated Midland Corp.
Contract Pharm
Cypress Pharmaceutical Inc.
Deltex Pharmaceuticals Inc.
Direct Dispensing Inc.
Dispensing Solutions
Edwards Pharmaceuticals
Hi Tech Pharmacal Co. Inc.
Iopharm Laboratories Inc.
Ivax Pharmaceuticals
Kowa Pharmaceuticals America Inc.
Kraft Pharmaceutical Co. Inc.
Larken Laboratories Inc.
Liberty Pharmaceuticals
Magna Pharmaceuticals
Major Pharmaceuticals
Mallinckrodt Inc.
McNeil Laboratories
Meda AB
Misemer Pharmaceuticals Inc.
Mismer Pharmace
Nucare Pharmaceuticals Inc.
PD-Rx Pharmaceuticals Inc.
Pecos Pharmaceutical Inc.
Perrigo Co.
Physicians Total Care Inc.
Prepackage Specialists
Provident Pharmaceuticals LLC
Qualitest
Rico Pharmacal
River's Edge Pharmaceuticals
Rugby Laboratories
S&P Healthcare
Schering-Plough Inc.
Time-Cap Labs
Tya Pharmaceuticals
Watson Pharmaceuticals
Wockhardt Ltd.

Dosage forms

Form	Route	Strength
Granule	Oral
Capsule, liquid filled	Oral
Tablet, effervescent	Oral
Granule, effervescent	Oral
Powder, for solution	Oral
Syrup	Oral	2 mg/5mL
Liquid; tablet	Intramuscular; Oral; Subcutaneous
Liquid; tablet	Oral; Parenteral
Granule, for solution	Oral
Liquid	Topical
Tablet, chewable	Oral
Liquid	Oral
Solution	Oral
Tablet, extended release	Oral	12 mg/1
Tablet, extended release	Oral	12 mg
Kit; tablet; tablet, extended release	Oral
Tablet	Oral	12 mg
Tablet, film coated, extended release	Oral	12 mg/1
Liquid	Intramuscular; Intravenous; Subcutaneous	10 mg
Syrup	Oral	2.5 mg
Kit; tablet	Oral
Kit	Oral
Kit
Tablet, extended release	Oral
Tablet, sugar coated	Oral
Lozenge	Oral	2 mg/1
Kit; powder, for solution	Oral
Liquid	Oral	2 mL/mL
Liquid	Oral	2 mg/5mL
Tablet, coated	Oral	4 mg/1
Kit; powder	Oral
Tablet	Oral	4 mg/1
Suspension	Oral
Tablet, film coated	Oral
Capsule	Oral	1.25 mg/1
Suspension, extended release	Oral
Capsule, delayed release pellets	Oral
Capsule	Oral
Tablet, multilayer	Oral
Tablet	Oral	4 mg
Powder	Oral
Capsule, gelatin coated	Oral
Tablet	Oral
Tablet, coated	Oral
Syrup	Oral
Capsule, extended release	Oral

Prices

Unit description	Cost	Unit
Ahist 12 mg tablet	1.1USD	tablet
Myci chlor-tan 8 mg caplet	0.75USD	caplet
Chlorpheniramine powder	0.67USD	g
Chlor-trimeton allergy	0.31USD	each
Chlor-trimeton 8 mg repetab	0.24USD	tablet
Aller-chlor 4 mg tablet	0.06USD	tablet
Pediacare allergy solution	0.05USD	ml
Allergy 4 mg tablet	0.04USD	tablet
Chlorpheniramine 4 mg tablet	0.02USD	tablet

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US7863287	No	2007-02-28	2027-02-28	US
US8062667	No	2009-03-29	2029-03-29	US
US8790700	No	2007-03-15	2027-03-15	US
US9066942	No	2012-01-03	2032-01-03	US
US6383471	No	1999-04-06	2019-04-06	US
US6248363	No	1999-11-23	2019-11-23	US
US9107921	No	2012-01-03	2032-01-03	US

Properties

State

Liquid

Experimental Properties

Property	Value	Source
boiling point (°C)	142 °C	Not Available
water solubility	5500 mg/L (at 37 °C)	BEILSTEIN
logP	3.38	HANSCH,C ET AL. (1995)
pKa	9.13 (at 25 °C)	PERRIN,DD (1965)

Predicted Properties

Property	Value	Source
Water Solubility	0.0519 mg/mL	ALOGPS
logP	3.74	ALOGPS
logP	3.58	ChemAxon
logS	-3.7	ALOGPS
pKa (Strongest Basic)	9.47	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	16.13 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	80.85 m³·mol^-1	ChemAxon
Polarizability	30.82 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	+	0.9754
Blood Brain Barrier	+	0.962
Caco-2 permeable	+	0.8749
P-glycoprotein substrate	Substrate	0.6136
P-glycoprotein inhibitor I	Non-inhibitor	0.8782
P-glycoprotein inhibitor II	Non-inhibitor	0.9376
Renal organic cation transporter	Inhibitor	0.7916
CYP450 2C9 substrate	Non-substrate	0.8026
CYP450 2D6 substrate	Substrate	0.8919
CYP450 3A4 substrate	Substrate	0.6472
CYP450 1A2 substrate	Non-inhibitor	0.9046
CYP450 2C9 inhibitor	Non-inhibitor	0.9096
CYP450 2D6 inhibitor	Inhibitor	0.8932
CYP450 2C19 inhibitor	Non-inhibitor	0.9025
CYP450 3A4 inhibitor	Non-inhibitor	0.9023
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.7501
Ames test	Non AMES toxic	0.9132
Carcinogenicity	Non-carcinogens	0.9183
Biodegradation	Not ready biodegradable	1.0
Rat acute toxicity	3.3361 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.8702
hERG inhibition (predictor II)	Inhibitor	0.7145

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum Type	Description	Splash Key
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS	Not Available
GC-MS	GC-MS Spectrum - EI-B	splash10-0zfr-6290000000-2ca3230cde716588805e	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)	splash10-01b9-3900000000-ea4ccfd2afe05f49fc7a	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)	splash10-004i-0090000000-9e46eb080de95d4f8f8e	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)	splash10-014i-1920000000-d2d2acf559d9070a1d47	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - EI-B (Unknown) , Positive	splash10-0zfr-6190000000-2ca3230cde716588805e	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-qTof , Positive	Not Available
LC-MS/MS	LC-MS/MS Spectrum - , positive	splash10-001i-0290000000-03651b7b90a1745fdf23	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - , positive	splash10-0uy0-0960000000-1f750af75fe542c6c06f	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available
MS	Mass Spectrum (Electron Ionization)	splash10-0zfr-6490000000-8e58cd1c686f23a7dac6	View in MoNA
1D NMR	1H NMR Spectrum	Not Available
2D NMR	[1H,13C] 2D NMR Spectrum	Not Available

Taxonomy

Description

This compound belongs to the class of organic compounds known as pheniramines. These are compounds containing a pheniramine moiety, which is structurally characterized by the presence of a 2-benzylpyridine linked to an dimethyl(propyl)amine to form a dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine skeleton.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Pyridines and derivatives

Sub Class

Pheniramines

Direct Parent

Pheniramines

Alternative Parents

Chlorobenzenes / Aralkylamines / Aryl chlorides / Heteroaromatic compounds / Trialkylamines / Azacyclic compounds / Organopnictogen compounds / Organochlorides / Hydrocarbon derivatives

Substituents

Pheniramine / Chlorobenzene / Halobenzene / Aralkylamine / Aryl chloride / Benzenoid / Monocyclic benzene moiety / Aryl halide / Heteroaromatic compound / Tertiary aliphatic amine

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

tertiary amino compound, pyridines, monochlorobenzenes (CHEBI:52010 )

Targets

Details

1. Histamine H1 receptor

Kind: Protein
Organism: Human
Pharmacological action: yes
Actions: antagonist

General Function:: Histamine receptor activity
Specific Function:: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:: HRH1
Uniprot ID:: P35367
Uniprot Name:: Histamine H1 receptor
Molecular Weight:: 55783.61 Da

References

Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Tagawa M, Kano M, Okamura N, Higuchi M, Matsuda M, Mizuki Y, Arai H, Iwata R, Fujii T, Komemushi S, Ido T, Itoh M, Sasaki H, Watanabe T, Yanai K: Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine. Br J Clin Pharmacol. 2001 Nov;52(5):501-9. [PubMed:11736858 ]
Salata JJ, Jurkiewicz NK, Wallace AA, Stupienski RF 3rd, Guinosso PJ Jr, Lynch JJ Jr: Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine. Circ Res. 1995 Jan;76(1):110-9. [PubMed:8001268 ]
Hasenohrl RU, Kuhlen A, Frisch C, Galosi R, Brandao ML, Huston JP: Comparison of intra-accumbens injection of histamine with histamine H1-receptor antagonist chlorpheniramine in effects on reinforcement and memory parameters. Behav Brain Res. 2001 Oct 15;124(2):203-11. [PubMed:11640974 ]
Yasuda SU, Wellstein A, Likhari P, Barbey JT, Woosley RL: Chlorpheniramine plasma concentration and histamine H1-receptor occupancy. Clin Pharmacol Ther. 1995 Aug;58(2):210-20. [PubMed:7648771 ]
Nicholson AN, Pascoe PA, Turner C, Ganellin CR, Greengrass PM, Casy AF, Mercer AD: Sedation and histamine H1-receptor antagonism: studies in man with the enantiomers of chlorpheniramine and dimethindene. Br J Pharmacol. 1991 Sep;104(1):270-6. [PubMed:1686208 ]

Details

2. Sodium-dependent serotonin transporter

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitor

General Function:: Serotonin:sodium symporter activity
Specific Function:: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin an...
Gene Name:: SLC6A4
Uniprot ID:: P31645
Uniprot Name:: Sodium-dependent serotonin transporter
Molecular Weight:: 70324.165 Da

References

Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. [PubMed:9537821 ]

Details

3. Sodium-dependent noradrenaline transporter

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitor

General Function:: Norepinephrine:sodium symporter activity
Specific Function:: Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:: SLC6A2
Uniprot ID:: P23975
Uniprot Name:: Sodium-dependent noradrenaline transporter
Molecular Weight:: 69331.42 Da

References

Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. [PubMed:9537821 ]

Details

4. Sodium-dependent dopamine transporter

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitor

General Function:: Monoamine transmembrane transporter activity
Specific Function:: Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:: SLC6A3
Uniprot ID:: Q01959
Uniprot Name:: Sodium-dependent dopamine transporter
Molecular Weight:: 68494.255 Da

References

Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. [PubMed:9537821 ]

Enzymes

Details

1. Cytochrome P450 3A4

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Vitamin d3 25-hydroxylase activity
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:: CYP3A4
Uniprot ID:: P08684
Uniprot Name:: Cytochrome P450 3A4
Molecular Weight:: 57342.67 Da

References

Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Details

2. Cytochrome P450 2D6

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrateinhibitor

General Function:: Steroid hydroxylase activity
Specific Function:: Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:: CYP2D6
Uniprot ID:: P10635
Uniprot Name:: Cytochrome P450 2D6
Molecular Weight:: 55768.94 Da

References

Hamelin BA, Bouayad A, Drolet B, Gravel A, Turgeon J: In vitro characterization of cytochrome P450 2D6 inhibition by classic histamine H1 receptor antagonists. Drug Metab Dispos. 1998 Jun;26(6):536-9. [PubMed:9616188 ]
Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Details

3. Cytochrome P450 3A5

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Oxygen binding
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:: CYP3A5
Uniprot ID:: P20815
Uniprot Name:: Cytochrome P450 3A5
Molecular Weight:: 57108.065 Da

References

Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Details

4. Cytochrome P450 3A7

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Oxygen binding
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:: CYP3A7
Uniprot ID:: P24462
Uniprot Name:: Cytochrome P450 3A7
Molecular Weight:: 57525.03 Da

References

Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Transporters

Details

1. Solute carrier family 22 member 2

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitor

General Function:: Quaternary ammonium group transmembrane transporter activity
Specific Function:: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:: SLC22A2
Uniprot ID:: O15244
Uniprot Name:: Solute carrier family 22 member 2
Molecular Weight:: 62579.99 Da

References

Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. [PubMed:11758759 ]

Details

2. Solute carrier family 22 member 1

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitor

General Function:: Secondary active organic cation transmembrane transporter activity
Specific Function:: Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:: SLC22A1
Uniprot ID:: O15245
Uniprot Name:: Solute carrier family 22 member 1
Molecular Weight:: 61153.345 Da

References

Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. [PubMed:11758759 ]

Drug created on June 13, 2005 07:24 / Updated on September 01, 2017 10:36

Structure for DB01114 (Chlorphenamine)

Targets

References

References

References

References

Enzymes

References

References

References

References

Transporters

References

References