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Identification
NameChlorphenamine
Accession NumberDB01114  (APRD00001, DB09440)
TypeSmall Molecule
GroupsApproved
DescriptionA histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem]
Structure
Thumb
Synonyms
1-(p-chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine
2-[p-chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine
3-(p-chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
Chlorophenylpyridamine
Chlorphenamin
Chlorphenaminum
Chlorpheniramine
Chlorpheniramine polistirex
Chlorpheniraminum
Clorfenamina
Clorfeniramina
γ-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine
γ-(4-chlorophenyl)-γ-(2-pyridyl)propyldimethylamine
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Chlorpheniramine Maleate Injection USPLiquid10 mgIntramuscular; Intravenous; SubcutaneousOmega Laboratories LtdNot applicableNot applicableCanada
Chlortripolon Inj 10mg/mlLiquid10 mgIntramuscular; Intravenous; SubcutaneousSchering Plough Canada Inc1953-12-311999-08-04Canada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
4 Hour Allergy ReliefTablet4 mg/1OralBetter Living Brands, Llc1992-12-19Not applicableUs
Aller-chlorSyrup2 mg/5mLOralRugby Laboratories2014-03-20Not applicableUs
Aller-chlorSyrup2 mg/5mLOralRugby Laboratories, Inc.2003-01-17Not applicableUs
Aller-chlorTablet4 mg/1OralRugby Laboratories1992-12-19Not applicableUs
Aller-chlorTablet4 mg/1OralLake Erie Medical DBA Quality Care Products LLC1992-12-19Not applicableUs
AllergyTablet4 mg/1OralH E B1994-10-12Not applicableUs
AllergyTablet4 mg/1OralCardinal Health1992-12-19Not applicableUs
AllergyTablet4 mg/1OralSUPERVALU INC.1992-12-19Not applicableUs
AllergyTablet4 mg/1OralREMEDYREPACK INC.2009-02-26Not applicableUs
AllergyTablet4 mg/1OralMajor Pharmaceuticals1992-12-19Not applicableUs
AllergyTablet4 mg/1OralKroger Company1987-07-15Not applicableUs
AllergyTablet4 mg/1OralA S Medication Solutions Llc1992-12-19Not applicableUs
AllergyTablet4 mg/1OralHy Vee Inc1991-07-30Not applicableUs
AllergyTablet4 mg/1OralAllegiant Health2014-12-15Not applicableUs
AllergyTablet4 mg/1OralMc Kesson (Sunmark)1992-12-19Not applicableUs
AllergyTablet4 mg/1OralAidarex Pharmaceuticals LLC1992-12-19Not applicableUs
AllergyTablet4 mg/1OralA S Medication Solutions Llc1992-12-19Not applicableUs
Allergy NiteTablet4 mgOralBayer Inc Consumer CareNot applicableNot applicableCanada
Allergy ReliefTablet, coated4 mg/1OralTop Care2016-11-01Not applicableUs
Allergy ReliefTablet4 mg/1OralMc Kesson (Health Mart)1992-12-19Not applicableUs
Allergy ReliefTablet4 mg/1OralGeri Care Pharmaceutical Corp2004-09-01Not applicableUs
Allergy ReliefTablet4 mg/1OralHarmon Store Inc.1992-12-19Not applicableUs
Allergy ReliefTablet4 mg/1OralFamily Dollar Services Inc1992-12-192019-07-08Us
Allergy ReliefTablet4 mg/1OralKroger Company1987-07-15Not applicableUs
Allergy ReliefTablet4 mg/1OralHy Vee Inc2016-09-29Not applicableUs
Allergy ReliefTablet4 mg/1OralKareway Product, Inc.2011-08-18Not applicableUs
Allergy ReliefTablet, coated4 mg/1OralDiscount Drug Mart2014-05-19Not applicableUs
Allergy ReliefTablet4 mg/1OralCVS Pharmacy1987-07-15Not applicableUs
Allergy ReliefTablet4 mg/1OralChain Drug Consortium1992-12-19Not applicableUs
Allergy ReliefTablet, coated4 mg/1OralChain Drug Marketing Association2014-10-01Not applicableUs
Allergy ReliefTablet4 mg/1OralRite Aid1992-12-19Not applicableUs
Allergy Relief 4 HourTablet4 mg/1OralWin Co Foods, Llc1992-12-19Not applicableUs
Allergy TimeTablet4 mg/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Allergy TimeTablet4 mg/1OralREMEDYREPACK INC.2014-04-29Not applicableUs
Allergy TimeTablet4 mg/1OralTIME CAP LABS INC2011-02-08Not applicableUs
AllergyniteTablet4 mg/1OralBayer Health Care Llc2016-04-15Not applicableUs
Anti AllergyTablet4 mg/1OralAdvance Pharmaceutical Inc.2002-01-09Not applicableUs
Careone Allergy ReliefTablet4 mg/1OralAmerican Sales Company2004-05-18Not applicableUs
Chlor-allergy 4-hourTablet4 mg/1OralGREAT LAKES WHOLESALE, MARKETING, & SALES, INC.1992-12-19Not applicableUs
Chlor-trimeton 12 HourTablet, extended release12 mg/1OralSchering Plough Health Care Products2010-01-04Not applicableUs
Chlor-trimeton 4hourTablet4 mg/1OralMSD Consumer Care, Inc.1975-12-31Not applicableUs
Chlor-tripolonTablet4 mgOralBayer Inc Consumer Care1988-12-31Not applicableCanada
Chlor-tripolon 12 HourTablet, extended release12 mgOralBayer Inc Consumer Care1988-12-31Not applicableCanada
Chlor-tripolon Night Time Allergy ReliefTablet12 mgOralSchering Plough Canada IncNot applicableNot applicableCanada
Chlorphen SRTablet, film coated, extended release12 mg/1OralGm Pharmaceuticals2010-06-15Not applicableUs
ChlorpheniramineTablet4 mg/1OralL&R Distributors, Inc.1992-12-19Not applicableUs
Chlorpheniramine MaleateTablet4 mg/1OralContract Pharmacy Services Pa2010-08-30Not applicableUs
Chlorpheniramine MaleateTablet, film coated, extended release12 mg/1OralKvk Tech, Inc.2010-06-15Not applicableUs
Chlorpheniramine MaleateTablet4 mg/1OralRugby Laboratories Inc.2000-05-30Not applicableUs
Chlorpheniramine MaleateTablet4 mg/1OralDIRECT RX2014-01-01Not applicableUs
Chlorpheniramine MaleateTablet4 mg/1OralSDA Laboratories, Inc.2010-05-19Not applicableUs
Chlorpheniramine MaleateTablet4 mg/1OralClinical Solutions Wholesale2000-05-30Not applicableUs
Chlorpheniramine MaleateTablet4 mg/1Oralbryant ranch prepack2000-05-30Not applicableUs
Chlorpheniramine MaleateTablet4 mg/1OralContract Pharmacy Services Pa2011-01-10Not applicableUs
Chlorpheniramine MaleateTablet, film coated, extended release12 mg/1OralCARDINAL HEALTH, INC.2010-12-20Not applicableUs
Chlorpheniramine MaleateTablet4 mg/1OralContract Pharmacal Corp2001-01-24Not applicableUs
Chlorpheniramine MaleateTablet4 mg/1OralContract Pharmacy Services Pa2010-08-25Not applicableUs
Chlorpheniramine Maleate 4 mgTablet4 mg/1OralReliable 1 Laboratories Llc2015-11-01Not applicableUs
Chlorpheniramine Maleate 4 mgTablet4 mg/1OralREMEDYREPACK INC.2016-11-08Not applicableUs
Chlorpheniramine Maleate 4mg TabletTablet4 mgOralJamp Pharma Corporation2005-02-25Not applicableCanada
Chlorpheniramine Maleate Tab 4mgTablet4 mgOralEverest Pharmaceuticals Ltd.1979-12-311999-07-14Canada
Chlorpheniramine Maleate Tab 4mgTablet4 mgOralBionatal Drug Co1979-12-311999-07-14Canada
Chlorpheniramine Tablets, 4 mgTablet4 mgOralLogan Pharmaceuticals Inc.Not applicableNot applicableCanada
ChlortabTablet4 mg/1OralWestern Family Foods Inc2007-05-22Not applicableUs
ChlortabsTablet4 mg/1OralWal Mart Stores Inc1992-12-19Not applicableUs
Chlortripolon Syr 2.5mg/5mlSyrup2.5 mgOralSchering Plough Canada Inc1951-12-312007-08-03Canada
Clear Choice Allergy ReliefTablet4 mg/1OralAthlete's Needs Inc2012-08-23Not applicableUs
Complete Allergy Relief 4-hourTablet, coated4 mg/1OralSMART SENSE (Kmart)2015-06-30Not applicableUs
Cvshealth Childrens Allergy Relief PopsLozenge2 mg/1OralCVS Pharmacy, Inc.2015-10-13Not applicableUs
Ed ChlorpedLiquid2 mL/mLOralEDWARDS PHARMACEUTICALS, INC.2011-04-28Not applicableUs
Ed Chlorped JrLiquid2 mg/5mLOralEDWARDS PHARMACEUTICALS, INC.2011-03-04Not applicableUs
Ed-chlortanTablet, coated4 mg/1OralEDWARDS PHARMACEUTICALS, INC.2011-06-07Not applicableUs
Equaline AllergyTablet4 mg/1OralSupervalu Inc2004-08-30Not applicableUs
Good Neighbor Pharmacy AllergyTablet4 mg/1OralAmerisource Bergen1989-07-15Not applicableUs
Good Sense AllergyTablet4 mg/1OralL Perrigo Company1991-07-29Not applicableUs
Good Sense Allergy ReliefTablet4 mg/1OralL. Perrigo Company2016-09-29Not applicableUs
Good Sense Allergy Relief 4 HourTablet4 mg/1OralL. Perrigo Company1991-07-29Not applicableUs
Haben HerbCapsule1.25 mg/1OralBeverly Hills Holdings Co,. Ltd.2014-08-27Not applicableUs
Health Mart Allergy ReliefTablet4 mg/1OralMc Kesson2012-01-18Not applicableUs
Histalon Tab 4mgTablet4 mgOralIcn Canada Ltd.1962-12-311998-08-13Canada
Medique ChlorphenTablet4 mg/1OralUnifirst First Aid Corporation2011-10-01Not applicableUs
Novo-pheniramTablet4 mgOralTeva Canada Limited1967-12-31Not applicableCanada
Sun Mark Allergy AntihistamineTablet4 mg/1OralMc Kesson2003-09-19Not applicableUs
Sunmark Allergy ReliefTablet4 mg/1OralMcKesson2016-07-13Not applicableUs
Teldrin Allergy ReliefTablet4 mg/1OralGemini Pharmaceuticals, Inc.2010-07-05Not applicableUs
Topcare AllergyTablet4 mg/1OralTopco Associates LLC1995-10-06Not applicableUs
Topcare Allergy Relief 4 HourTablet4 mg/1OralTopco Associates LLC1995-10-06Not applicableUs
Wal-finateTablet4 mg/1OralWalgreen Company1992-12-19Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Chlorpheniramine MaleateTablet4 mg/1OralCardinal Health2011-06-06Not applicableUs
International Brands
NameCompany
Chlo-AmineNot Available
Chlor-TrimetonSchering-Plough
ClofeniraminaNot Available
HaynonNot Available
PiritonGlaxoSmithKline
Brand mixtures
NameLabellerIngredients
999 Cold RemedyChina Resources Sanjiu Medical & Pharmaceutical Co Ltd
999 Cold Remedy GranularChina Resources Sanjiu Medical & Pharmaceutical Co Ltd
999 Ganmaoling ColdKingsway
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, Phenylephrine HydrochlorideAAA Pharmaceutical, Inc.
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine HydrochlorideAAA Pharmaceutical, Inc.
Acti PEP & L Development, LLC
Actifed PEMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Actifed PE PlusMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Adult Flu and Cough SanafluGrandall Distributing Co., Inc.
Advil Allergy and Congestion ReliefNavajo Manufacturing Company Inc.
Advil Allergy SinusPfizer Consumer Healthcare
Advil Cold & Sinus Convenience PackPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Cold and Sinus NighttimePfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Cold and Sinus PlusPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Alka Seltzer Plus ColdNavajo Manufacturing Company Inc.
Alka-seltzer PlusLil' Drug Store Products, Inc
Alka-seltzer Plus Cold and CoughBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Cold and Cough FormulaBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Cold Formula (cherry Burst)Bayer Health Care Consumer Care
Alka-seltzer Plus Cold Formula (orange Zest)Bayer Health Care Consumer Care
Alka-seltzer Plus Cold Medicine Sparkling OriginalBayer Health Care Consumer Care
Alka-seltzer Plus Fast Crystals Packs Cold FormulaBayer Health Care Llc, Consumer Care
Alka-seltzer Plus Fast Packs Cold and Flu FormulaBayer Corporation Consumer Care Division
Alka-seltzer Plus Flu FormulaBayer Corporation Consumer Care Division
Alka-seltzer Plus Severe Cold and Flu FormulaBayer Health Care Llc Consumer Care
Alka-seltzer Plus Severe Sinus and ColdBayer Health Care Consumer Care
Alka-seltzer Plus-D Multi-symptom Sinus and ColdBayer Health Care Llc, Consumer Care
Allerest PEInsight Pharmaceuticals
AllerfedL&R Distributors, Inc.
Allerfed Cold and AllergyChain Drug Marketing Association Inc
Allerfed Cold and Allergy PEWestern Family Foods, Inc.
Allergie Extra FortTherapharma Inc.
AllergyL. Perrigo Company
Allergy + Sinus Relief Extra Strength TabletsPharmetics (2011) Inc
Allergy + Sinus Relief Extra Strength Tablets PEPharmetics (2011) Inc
Allergy + Sinus Relief Regular CapletsPharmetics (2011) Inc
Allergy and Pain Relief Multi-symptomWin Co Foods, Llc
Allergy and Sinus PE Maximum StrengthMeijer
Allergy and Sinus Relief Extra StrengthJamp Pharma Corporation
Allergy and Stuffy NoseAccudial Pharmaceutical, Inc.
Allergy Multi SymptomKroger Company
Allergy Multi-symptomAmerican Sales Company
Allergy Mutli-symptomArmy and Air Force Exchange Service
Allergy Pain ReliefHy Vee Inc
Allergy ReliefKroger Company
Allergy Relief Multi-symptomDolgencorp, LLC
Allergy Relief MultisymptomSelect Corporation
Allergy Sinus MedicationLil' Drug Store Products Inc
Allergy Sinus Medication - CapletWestcan Pharmaceuticals Ltd.
Allergy Sinus PEPublix Super Markets Inc
Allergy Sinus PE Pain ReliefPublix Super Markets Inc
Allpanto SSAMSUNG PHARM IND. CO., LTD.
Altilan ClAlternative Pharmacal Corporation
Ana-kitMiles Canada Inc. Pharmaceutical Division
Ana-kit (2mg/tab Orl, 1mg/ml Liq Sc Im)Hollister Stier Laboratories Llc
Anakit Insect Sting Treatment KitHollister Stier, Unit Pharm, Division Of Miles Canada Inc.
Aphedrid Cold and AllergyArmy and Air Force Exchange Service
Atuss DS Tannate SuspensionAtley Pharmaceuticals, Inc.
Bactimicina Childrens Cough and ColdDLC Laboratories, Inc.
Baczol Cold MedicineLex Inc
Balamine DM SyrupBallay Pharmaceuticals, Inc.
Bc Sinus Congestion and PainMedtech Products Inc.
Benylin 1 Nightime With MenthactinMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin A-D-AH Extra Strength CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin A-D-AH Regular Strength CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin All-IN-one Cold & Flu NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin All-IN-one Cold and Flu Night Extra Strength SyrupMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Cold & Sinus PlusMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Cold and Sinus NightMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin D-AH for ChildrenMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin DM-D-AH Chewables for ChildrenMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin DM-D-AH for ChildrenMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Extra Strength All-IN-one Cold and Flu NightimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Extra Strength Mucus & Phlegm Plus Cold Relief NightMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin for Children All-IN-one Cold & FeverMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin for Children All-IN-one Cold and FeverMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin for Children Cough Stuffy and Runny NoseMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Bio-B KidsAdvanced Generic Corporation
Bio-rytussAdvanced Generic Corporation
Bronchodex D CapProdemdis Enr.
Broncochem Cold and Flu CapletsLabotorio Magnachem International Srl
Broncochem Cold and Flu TeaLaboratorio Magnachem International Srl
Broncochem Expectorant IILaboratorio Magnachem International Srl
BronkidsPortal Pharmaceutical
Buckley's Complete Extra Strength Cough, Cold and Flu NightThe Buckley's Company
Calmadol PlusGrandall Distributing Co., Inc.
CapcofCapital Pharmaceutical, Llc
Carbaphen ChGil Pharmaceutical Corp
Carbaphen Ped ChGil Pharmaceutical Corp
Care One Cold and AllergyAmerican Sales Company
Care One Cold Head CongestionAmerican Sales Company
Care One Cold Multi SymptomAmerican Sales Company
Care One SinusAmerican Sales Company
Care One Sinus and Allergy PEAmerican Sales Company
Careone Sinus Plus HeadacheAmerican Sales Company
CarepantoSAMSUNG PHARM IND. CO., LTD.
Children's Advil Cold & Flu Multi-symptomPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Children's Coltalin Fruit Flavor Chewable Cold TabletsFortune Pharmacal Co. Ltd.
Children's Nicold MedicineTanta Pharmaceuticals Inc
Children's Nyquil LiquidProcter & Gamble Inc
Children's Tylenol ColdMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold and CoughMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold Chewable TabletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold LiquidMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold Liquid With DMMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold SuspensionMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Complete Cold, Cough & FeverMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cough and Runny NoseMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Childrens ColtalinFortune Pharmacal Company Limited
Childrens Dimetapp Long Acting Cough Plus ColdRichmond Division of Wyeth
Childrens Dimetapp Multisymptom Cold and FluRichmond Division of Wyeth
Childrens Flu ReliefCVS Pharmacy
Childrens Multi Symptom Fever and ColdKroger Company
Childrens Multi-symptom Cold Plus Dye-freeQUALITY CHOICE (Chain Drug Marketing Association)
Childrens Plus ColdWalgreens
Childrens Plus Cold GrapeCVS
Childrens Plus Cough and Runny NoseMajor Pharmaceuticals
Childrens Plus FluWalgreens
Childrens Plus Flu With PECVS
Childrens Plus Multi Symptom ColdRite Aid Corporation
Childrens Plus Multi Symptom Cold Dye FreeAmerisource Bergen (Good Neighbor Pharmacy) 46122
Childrens Plus Multi-symptom Cold Grape With PERite Aid
Childrens Plus Multi-symptom Grape With PEBest Choice
Childrens Plus Multi-symptom With PEKinray, Inc
Childrens Robitussin Cough and Cold Long-actingRichmond Division of Wyeth
Childrens Robitussin Nighttime Cough Long-acting DMRichmond Division of Wyeth
Chlor Tripolon Decongest SyrSchering Plough Canada Inc
Chlor-tripolon Day and NightSchering Plough Canada Inc
Chlor-tripolon Decon Ext Str Repetabs 12Schering Plough Canada Inc
Chlorpheniramine Maleate, Phenylephrine HydrochlorideAAA Pharmaceutical, Inc.
Codar ArRespa Pharmaceuticals, Inc.
Codeine and Chlorpheniramine Maleate ERNexgen Pharma, Inc.
ColdHy Vee Inc
Cold & CoughPharma Strides Canada Corporation
Cold & Cough Extra StrengthPharma Strides Canada Corporation
Cold & Stuffy NoseAccudial Pharmaceutical Inc
Cold + Sinus Daytime Cold + Sinus NighttimeVita Health Products Inc
Cold + Sinus NighttimeVita Health Products Inc
Cold + Sinus PlusVita Health Products Inc
Cold and AllergyMeijer Distribution Inc
Cold and Allergy Maximum StrengthDolgencorp, Inc. (DOLLAR GENERAL & REXALL)
Cold and Allergy PEKroger Company
Cold and Allergy ReliefRite Aid
Cold and Cough High Blood PressureVALUE MERCHANDISERS COMPANY, INC.
Cold and FluRite Aid
Cold and Flu BPL&R Distributors, Inc.
Cold and Flu HbpWOONSOCKET PRESCRIPTION CENTER,INCORPORATED
Cold and Flu Nighttime Relief Syrup Extra StrengthPharmetics (2011) Inc
Cold and Flu Relief Hbp Maximum Strength Multi-symptomRite Aid
Cold and Nasal Congestion Relief Nighttime Extra StrengthPharmetics (2011) Inc
Cold and Sinus PlusMarcan Pharmaceuticals Inc
Cold Decongestant Long Acting CapNovopharm Limited
Cold Formula Daytime Nighttime, Non-aspirin, Multi-symptomGreenbrier International, Inc.
Cold Head CongestionHannaford Brothers Company
Cold Head Congestion Daytime / NighttimeAAA Pharmaceutical, Inc.
Cold Head Congestion Night TimeDolgencorp, LLC
Cold Head Congestion NighttimeAmerican Sales Company
Cold MedicationVita Health Products Inc
Cold Medication Extra Strength Night TimePharmascience Inc
Cold Medication Reg Strength N TabProdemdis Enr.
Cold Medication Regular Nighttime TabletsPharmetics (2011) Inc
Cold Medication Regular Nighttime Tablets PEPharmetics (2011) Inc
Cold Medicine XL-3 for ChildrenSelder, S.A. de C.V.
Cold Medicine Xl3Selder, S.A. de C.V.
Cold Multi Symptom Daytime NighttimeChain Drug Marketing Association
Cold Multi Symptom NighttimeChain Drug Marketing Association
Cold Multi Symptom ReliefVita Health Products Inc
Cold Multi-symptomL&R Distributors, Inc.
Cold Multi-symptom Daytime and NighttimeGood Sense
Cold Multi-symptom Daytime NighttimeAAA Pharmaceutical, Inc.
Cold Multi-symptom Night-timeAllegiant Health
Cold Multi-symptom NighttimeAmerican Sales Company
Cold Multi-symptom, Daytime / NighttimeWalgreen Company
Cold PEHy Vee Inc
Cold ReliefMeijer Distribution Inc
Cold Relief Duo PackPharmetics (2011) Inc
Cold Relief Multi SymptomMeijer Distribution Inc
Cold Relief Multi-symptomTop Care
Cold Relief Nightime TabletJamp Pharma Corporation
Cold Remedy Gan Mao LingInternational Nature Nutraceuticals
Cold Remedy SoothingInternational Nature Nutraceuticals
Cold,sore Throat Pain & Cough Ultra StrengthThe Winning Combination Inc.
Cold/flu Multi-symptom Relief Daytime/nighttimeDolgencorp, LLC
Coldaside ColdTanta Pharmaceuticals Inc
Coldaside Cold & Flu Extra StrengthTanta Pharmaceuticals Inc
Coldaside Cough & ColdTanta Pharmaceuticals Inc
ColtalinFortune Pharmacal Company Limited
Coltalin Cold & Allergy TabletsFortune Pharmacal Co. Ltd.
Coltalin-DMFortune Pharmacal Company Limited
CompleteVita Health Products Inc
Complete Allergy and Sinus Multi SymptomGREAT LAKES WHOLESALE, MARKETING, & SALES, INC.
Complete One Cold and Flu Nightime Extra Strength LiquidTanta Pharmaceuticals Inc
Comtrex Cough and Cold Day/nightDr. Reddy's Laboratories Inc.
Comtrex Maximum Strength Day / Night Severe Cold and SinusNovartis Consumer Health, Inc.
Conrx Allergy SinusEagle Distributors,Inc
Conrx Allergy Sinus Multi-symptomsEagle Distributors,Inc.
Contac Cold and Flu Maximum StrengthMeda Consumer Healthcare Inc.
Contac Cold and Flu NightMeda Consumer Healthcare Inc.
Contac Cold CapsulesSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Contac Cold Extra Strength CapsulesSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Contac Cold Nasal Congestion-nighttimeGlaxosmithkline Consumer Healthcare Inc.
Contac Cough Cold and Flu CapletsSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Contac Night Cough SyrupGlaxosmithkline Consumer Healthcare Inc.
Contact C SrcSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
CopantoSAMSUNG PHARM IND. CO., LTD.
Coricidin Cold & FluBayer Inc Consumer Care
Coricidin Cold & Flu Extra StrengthBayer Inc Consumer Care
Coricidin Cold & Flu Multi-symptomBayer Inc Consumer Care
Coricidin Cough & ColdBayer Inc Consumer Care
Coricidin D Flu, Nasal and SinusSchering Plough Healthcare Products Canada, A Division Of Schering Canada Inc.
Coricidin D Long Acting TabSchering Plough Canada Inc
Coricidin D TabSchering Plough Canada Inc
Coricidin Hbp Cold and FluMSD Consumer Care, Inc.
Coricidin Hbp Cough and Cold Cough Suppressant, AntihistamineMSD Consumer Care, Inc.
Coricidin Hbp Day and NightMSD Consumer Care, Inc.
Coricidin Hbp Maximum Strength FluMSD Consumer Care, Inc.
Coricidin Sinus Headache TabSchering Plough Canada Inc
Coricidin TabSchering Plough Canada Inc
Corsym SuspensionCiba Self Medication
Cough & ColdAccudial Pharmaceutical Inc
Cough and ColdMajor Pharmaceuticals
Cough and Cold HbpArmy and Air Force Exchange Service
Cough and Cold Hbp Decongestant-freeL.N.K. International, Inc.
Cough and Cold Relief HbpSUPERVALU INC.
Cough and Cold Xl3 XtraProgela, S.A. De C.V.
Cough and Runny Nose Childrens PlusTOP CARE (Topco Associates LLC)
Cough, Cold & Flu Super StrengthThe Winning Combination Inc.
Counteract Sinus and AllergyMelaleuca Of Canada Inc.
Dallergy DropsLaser Pharmaceuticals, LLC
Day & Night Combo PackThe Winning Combination Inc.
Daytime Cold, Nighttime Cold Multi-symptomSUPERVALU INC.
De-chlor DMCypress Pharmaceutical, Inc.
Defensol DMenper Distributors, Inc.
Defensol D (multi Symptom Effervescent Tablets)Menper Distributors Inc.
Dg Health Allergy Multi SymptomDolgencorp, LLC
Dg Health Cold and AllergyDolgencorp Inc
Dg Health Cold Head CongestionDolgencorp, LLC
Dg Health Cold Multi Symptom Nite TimeDolgencorp Inc
Dg Health Sinus Congestion and PainDolgencorp, LLC
Dimetapp Nighttime Cold Extra Strength CapletsPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Dimetapp Nighttime Cold TabletsWyeth Consumer Healthcare Inc.
Dometuss-DADomel Laboratories
Dometuss-NRDomel Laboratories
DonatussinLaser Pharmaceuticals, LLC
Donatussin DM Drops DMLaser Pharmaceuticals, LLC
Dristan CapsulesWhitehall Robins Inc.
Dristan Cold MultisymptomPfizer Consumer Healthcare
Dristan Extra Strength CapletsPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Dristan TabletsPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
DrymaxJay Mac Pharmaceuticals Llc
Drymax AFJay Mac Pharmaceuticals
Ed A-histEDWARDS PHARMACEUTICALS, INC.
Ed A-hist DMEDWARDS PHARMACEUTICALS, INC.
Ed Chlorped DEDWARDS PHARMACEUTICALS, INC.
Ed-A-hist DMEDWARDS PHARMACEUTICALS, INC.
Effervescent Cold ReliefCardinal Health, Inc
Endacof CLarken Laboratories, Inc.
Entre-SBrookstone Pharmaceuticals, Inc.
Equaline Childrens ColdSupervalu Inc
Equaline Daytime and Nighttime ColdSupervalu Inc
Equaline Nighttime Cold Multi SymptomSupervalu Inc
Extra Strength Allergy and Sinus ReliefPendopharm Division Of De Pharmascience Inc
Extra Strength Allergy Plus Sinus ReliefKsl Pharmaceuticals
Extra Strength Allergy Sinus MedicationStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Extra Strength Cold Medication Night Time ReliefGenvion Corporation
Extra Strength Cold Medication Nighttime ReliefVita Health Products Inc
Extra Strength Cold Medication Nighttime RlfStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Extra Strength Contac C - SrcSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Extra Strength Day and Night Cold MedicationPendopharm Division Of De Pharmascience Inc
Extra Strength Neocitran Flu NightNovartis Consumer Health Canada Inc.
Extra Strength Neocitran Total NightNovartis Consumer Health Canada Inc.
Extra Strength Nighttime Cold ReliefPendopharm Division Of De Pharmascience Inc
Extra Strength Nighttime Cold Relief PEVita Health Products Inc
Extra Strength Nighttime Cold Relief-capletKsl Pharmaceuticals
Extra Strength Nighttime Flu PEVita Health Products Inc
Extra Strength Tylenol AllergyMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Allergy Sinus CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Cold & Sinus NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Cold and Flu PowderMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Cold NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Cold Nighttime CapletMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Complete Cold, Cough & Flu Plus Mucus Relief NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Flu NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Sinus NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Sinus Pain and Congestion NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Flu Bp Maximum StrengthL&R Distributors, Inc.
Flu HbpWALGREEN CO.
Flu Hbp Maxium StrengthChain Drug Marketing Association Inc
Flu Multi Symptom ReliefVita Health Products Inc
Flu Relief ChildrensTOP CARE (Topco Associates LLC)
FluactPharmaline Incorporated
Formule 115 DMFrega Inc.
Fulton Street Market ColdAccess Business Group LLC
Ganmaoling 999Kingsway Trading
GencontussKramer Novis
Good Neighbor Pharmacy Allergy Multi SymptomAmerisource Bergen
Good Neighbor Pharmacy ColdAmerisource Bergen
Good Neighbor Pharmacy Cold and Allergy PEAmerisource Bergen
Good Neighbor Pharmacy Cold Head CongestionAmerisource Bergen
Good Neighbor Pharmacy Cold Plus Multi SymptomAmerisource Bergen
Good Neighbor Pharmacy SinusAmerisource Bergen
Good Neighbor Pharmacy Sinus and Allergy PEAmerisource Bergen
Good Neighbor Pharmacy Sinus Congestion and PainAmerisource Bergen
Good Sense Allergy Multi SymptomL. Perrigo Company
Good Sense ColdL Perrigo Company
Good Sense Cold and AllergyL Perrigo Company
Good Sense Sinus and Allergy PEL Perrigo Company
Grippalin & C TabDistributions Multi Pro Inc.
Grippe Extra Fort NuitTherapharma Inc.
HanshinnocolHan Kook Shin Yak Pharmaceutical Co., Ltd.
Head CongestionMeijer Distribution Inc
Head Congestion Cold ReliefWoonsocket Prescription Center, Incorporated
Head Congestion Daytime and Nighttime ColdSUPERVALU INC.
Healthy Accents Allergy Multi SymptomDZA Brands LLC
Healthy Accents Childrens Multi Symptom Fever and ColdDZA Brands LLC
Healthy Accents ColdDZA Brands LLC
Healthy Accents Cold Head CongestionDZA Brands LLC
Healthy Accents Multi Symptom ColdDZA Brands LLC
Healthy Accents SinusDZA Brands LLC
High Blood Pressure Cold and FluBedrock Brands, Llc
Hot Lemon Night Time Total Extra StrengthPharmetics (2011) Inc
Hot Lemon Relief for Sore Throat and Cough Extra StrengthJamp Pharma Corporation
Hot Lemon Relief for Symptoms Of Cough, Cold and FluPatheon Laboratories
Hot Lemon Relief for Symptoms Of Cough, Cold and Flu Extra StrengthPharmetics (2011) Inc
Hybrid CFHybrid Rx Llc
Hydrocodone Bitartrate and Chlorpheniramine Maleate SolutionTris Pharma Inc
Hydrocodone Bitartrate, Chlorpheniramine Maleate and Pseudoephedrine HydrochloridePaddock Laboratories, LLC
Hydrocodone Bitartrate, Chlorpheniramine Maleate, and Pseudoephedrine HClCypress Pharmaceutical, Inc.
Hydrocodone Bitartrate, Chlorpheniramine Maleate, and Pseudoephedrine Hydrochloride Oral SolutionTris Pharma Inc
Hydrocodone Polistirex and Chlorpheniramine PolisitrexAtlantic Biologicals Corps
Hydrocodone Polistirex and Chlorpheniramine PolistirexPhysicians Total Care, Inc.
Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended-releaseAristos Phamaceuticals, Inc.
Hydrocodone Polistirex and Chlorpheniramine Polistirex PennkineticAtlantic Biologicals Corps
Infants Tylenol Cold Suspension DropsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Jack & Jill Children's Formula Cough LiquidThe Buckley's Company
Jack & Jill CompleteThe Buckley's Company
Jack & Jill Cough and ColdThe Buckley's Company
Jack & Jill Cough, Cold & Flu Junior Strength TabletsThe Buckley's Company
Junior Strength Cold DM - TabletVita Health Products Inc
Junior Strength Tylenol Cold and CoughMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Junior Strength Tylenol Complete Cold, Cough & FeverMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Kgs Allergy SoothingKingsway
Kidkare Cough/coldRugby Laboratories, Inc.
Kirkland Signature ColdCostco Wholesale Company
Leader Allergy Multi SymptomCardinal Health
Leader Cold and AllergyCardinal Health
Leader Cold Head CongestionCardinal Health
Leader Sinus and Allergy PECardinal Health
Lexuss 210Centurion Labs
Lil Drug Store Allergy Sinus ReliefLil' Drug Store Products, Inc.
Lohist DLarken Laboratories, Inc.
M-end DMR.A. Mc Neil Company
Madame Pearl's Cough SyrupWing Quon Enterprises Ltd.
Maux De Gorge Et De LA Toux Extra-fortPharmalab Inc.
Maximum Strength Allergy SinusWALGREEN CO.
Maximum Strength FluRite Aid
Maximum Strength Flu HbpDolgencorp, LLC
Medicament Pour Le Rhume, NuitLaboratoire Riva Inc
Medique Medicidin DUnifirst First Aid Corporation
Medique Onset ForteUnifirst First Aid Corporation
Members Mark AllergySam's West Inc
Metreton TabSchering Plough Canada Inc
Multi Symptom Cold ChildrensKroger Company
Multi Symptom Cold Childrens PlusQUALITY CHOICE (Chain Drug Marketing Association)
Multi Symptom Cold Plus ChildrensWestern Family Foods Inc
Multi Symptom Cold Plus Childrens Pain ReliefHy Vee Inc
Multi Symptom Cold Relief ChildrensCVS Pharmacy
Multi Symptom Fever and Cold ChildrensHy Vee Inc
Multi Sympton Cold Day NightKareway Product, Inc.
Multi-symptom AllergyWalgreen Company
Multi-symptom ColdValu Merchandisers Company
Multi-symptom Cold ReliefWOONSOCKET PRESCRIPTION CENTER,INCORPORATED
Multi-symptom Cold Relief Daytime, NighttimeTarget Corporation
Nasal + Sinus Cold FormulaVita Health Products Inc
Neo DM Drops DMLaser Pharmaceuticals, LLC
Neo Tuss SyrNeolab Inc
Neocitran Cough & Cold SyrupNovartis Consumer Health Canada Inc.
Neocitran Ultra Strength Total Flu NightGlaxosmithkline Consumer Healthcare Inc.
Night Time Cold Multi-symptomDolgencorp, LLC
Night Time Sinus Congestion and PainKroger Company
Night Time Total Extra StrengthPharmetics (2011) Inc
Nighttime ColdPublix Super Markets Inc
Nighttime Cold and Flu Relief Alcohol FreeCVS Pharmacy
Nighttime Cold Head CongestionFRED'S, INC.
Nighttime Cold Relief Extra Strength TabletsPharmetics (2011) Inc
Nighttime Cold Relief Extra Strength Tablets PEPharmetics (2011) Inc
Nighttime Extra Strength Contac Cold & Sore ThroatValeant Canada Lp Valeant Canada S.E.C.
Nighttime Extra Strength Contac Complete Cough, Cold & FluValeant Canada Lp/valeant Canada s.e.c.
Nighttime Extra Strength Contac Complete Cough, Cold & Flu Plus Vitamin CGlaxosmithkline Consumer Healthcare Inc.
Nighttime Multi-symptom ColdWALGREEN CO.
Nighttime Regular Strength Contac Cold Nasal CongestionGlaxosmithkline Consumer Healthcare Inc.
Nighttime Total Super StrengthThe Winning Combination Inc.
Nite Time (children's)Perrigo International
Nitetime Cold Relief Extra StrengthJamp Pharma Corporation
Nohist DMLarken Laboratories, Inc.
Nohist LqLarken Laboratories, Inc.
Norel AdUs Pharmaceutical Corporation
Norelcs CsUs Pharmaceutical Corporation
Once-A-day Benylin Cold CapKv Pharmaceutical Company
Ornade AF LiquidSmithkline Beecham Pharma Division Of Smithkline Beecham Inc
Ornade AF Spansule SrcSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Ornade DM 10 LiqSmithkline Beecham Pharma Division Of Smithkline Beecham Inc
Ornade DM 15 LiqSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Ornade DM 30 LiqSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Ornade Expectorant Cough FormulaSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Ornade LiquidSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Ornade Spansule SrcSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Otis Clapp ValihistUnifirst First Aid Corporation
Pain & Fever + ColdAccudial Pharmaceutical Inc
Pain & Fever + Cold & CoughAccudial Pharmaceutical Inc
Pain Relief PlusMeijer Distribution Inc
Pain Reliever Fever ReducerVelocity Pharma
Pancold SKafus Co., Ltd
Panto ASAMSUNG PHARM IND. CO., LTD.
Panto FluSAMSUNG PHARM IND. CO., LTD.
Pedia ReliefMajor Pharmaceuticals, Inc
Pediacare Childrens Plus Cough and Runny NoseBlacksmith Brands, Inc.
Pediacare Childrens Plus FluBlacksmith Brands, Inc.
Pediacare Childrens Plus Multisymptom ColdBlacksmith Brands, Inc.
Pediatric Cough and Cold MedicineSilarx Pharmaceuticals, Inc
Pentuss SrsRhone Poulenc Rorer Canada Inc.
Phenylhistine DhQualitest Pharmaceuticals
Physicianscare Allergy Multi-symptom ReliefAcme United Corporation
Plus Multi Symptom Cold Childrens Pain ReliefHannaford Brothers Company
Poly Hist PdPoly Pharmaceuticals, Inc.
Poly-tussin DMPoly Pharmaceuticals, Inc.
Prime's Sore Throat, Cough and Colds CapsulesPrime Health Ltd.
Pseudoephedrine PlusContract Pharmacal Corp
Quality Choice Effervescent Cold Relief PlusChain Drug Marketing Association
R-tannaPd Rx Pharmaceuticals, Inc.
R-tanna Pediatric SuspensionPrasco Laboratories
Rapid Release Multi-symptom Allergy ReliefWal Mart Stores Inc
Reg.str.cold Medic.(night Time Relief)capletWestcan Pharmaceuticals Ltd.
Regular Strength Tylenol Cold and Flu PowderMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Regular Strength Tylenol Cold NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Regular Strength Tylenol Cold Nighttime CapletMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Relief-PENor Med
Relievol Allergy Sinus Caplets Extra StrengthTanta Pharmaceuticals Inc
Rescon DMCapellon Pharmaceuticals, LLC
Rhume Extra Fort NuitTherapharma Inc.
Robitussin Peak Cold Nighttime Nasal ReliefRichmond Division of Wyeth
Robitussin Total Cough, Cold & Flu Extra StrengthPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Rx Act Sinus and Allergy PEH E B
Rycontuss Cherry FlavorOkendpharma, Inc.
Sanatos Cold Multi-symptomPharmadel LLC
Scot-tussin DM Maximum Strength Cough Suppressant and Cold ReliefIri Sys, Llc
Scot-tussin DM Sf Maximum Strength Cough ColdScot Tussin Pharmacal Co., Inc.
Shoprite AllergyWakefern Food Corporation
Shoprite Childrens Multi Symptom Cold ReliefWakefern Food Corporation
Sildec PE DMRebel Distributors Corp
Sine Off Sinus/cold MedicineGemini Pharmaceuticals, Inc.
Sine-off Allergy TabSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
SinusHy Vee Inc
Sinus and AllergyTOP CARE (Topco Associates LLC)
Sinus and Allergy Maximum StrengthWestern Family Foods Inc
Sinus and Allergy PEBetter Living Brands, Llc
Sinus and Allergy PE Maximum StrengthKroger Company
Sinus and Allergy Regular StrengthPharmetics (2011) Inc
Sinus and Allergy Releif PEP And L Development Of New York Corporation (Ready In Case)
Sinus and Allergy ReliefBetter Living Brands, Llc
Sinus and Allergy Relief PERite Aid
Sinus Congestion and PainMeijer Distribution Inc
Sinus Congestion and Pain Daytime NighttimeAAA Pharmaceutical, Inc.
Sinus Congestion and Pain Daytime/nighttimeWalgreen Company
Sinus Congestion and Pain NighttimeFRED'S, INC.
Sinus Extra Fort NuitTherapharma Inc.
Sinus Nighttime Extra Strength CapletsPharmetics (2011) Inc
Sinus Pain and CongestionCVS Pharmacy
Sinus Pain and Congestion NighttimeCVS Pharmacy
Sinus PE Plus Allergy Maximum StrengthCVS Pharmacy
Sinus Plus Allergy PE Maximum StrengthSUPERVALU INC.
Sinus Plus Headache Daytime and NighttimeGood Sense
Sinus ReliefWestern Family Foods Inc
Sinus Relief Congestion and Pain - Daytime and NighttimeAmeri Source Bergen
Sinus Relief Congestion and Pain NighttimeAmeri Source Bergen
Sinus Ultra Strength TabletJamp Pharma Corporation
Sinusales Extra Fort NuitProdemdis Enr.
Sinutab Extra Strength TabletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Sinutab PE Extra StrengthMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Sinutab PE NightimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Sinutab Regular Strength TabletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Sinutab With Codeine TabletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Smart Sense Childrens Multi Symptom Cold ReliefKmart Corporation
Smart Sense Multi Symptom ColdKmart Corporation
Smart Sense Multi Symptom Fever and Cold ChildrensKmart Corporation
Sohmed Allergy SinusSOHM Inc.
Sore Throat & Cough Ultra StrengthPharmascience Inc
StonaSato Pharmaceutical Co., Ltd.
Stona for ChildrenSato Pharmaceutical Co., Ltd.
Stona-SSato Pharmaceutical Co., Ltd.
StonarhiniSato Pharmaceutical Co., Ltd.
Sudafed Sinus & AllergyMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
SudogestMajor Pharmaceuticals
Sunmark Allergy Multi SymptomMc Kesson
Sunmark ColdMc Kesson
Sunmark Cold and AllergyMc Kesson
Sunmark Sinus and Allergy PE Maximum StrengthMc Kesson
Suphedrine PEWal Mart Stores Inc
Suphedrine PE Sinus Plus AllergyArmy and Air Force Exchange Service
Tabcin 500Salimex, S.A.
Theraflu Flu Cold and Cough MedicineSandoz Canada Inc
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Topcare Allergy Multi SymptomTopco Associates LLC
Topcare ColdTopco Associates LLC
Topcare Cold and AllergyTopco Associates LLC
Topcare Cold Head Congestion NighttimeTopco Associates LLC
Topcare Cold Nighttime Multi SymptomTopco Associates LLC
Topcare Sinus and Allergy PE Maximum StrengthTopco Associates LLC
Topcare Sinus Congestion and PainTopco Associates LLC
Total FluPharmetics (2011) Inc
Toux Rhume Et Grippe (extra-fort)Prodemdis Enr.
Triaminic Childrens Cold and AllergyNovartis Consumer Health, Inc.
Triaminic Cold & Nighttime CoughNovartis Consumer Health Canada Inc.
Triaminic Cold and AllergyNovartis Consumer Health Canada Inc.
Triaminic Cold and Allergy SyrupNovartis Consumer Health Canada Inc.
Triaminic Cold and CoughNovartis Consumer Health Canada Inc.
Triaminic Cold Cough and FeverNovartis Consumer Health Canada Inc.
Triaminic DM Expectorant SyrNovartis Consumer Health Canada Inc.
Triaminic Expectorant SyrNovartis Consumer Health Canada Inc.
Triaminic Multi-symptom FeverNovartis Consumer Health, Inc.
Triaminic Multi-symptom Fever and ColdNovartis Consumer Health, Inc.
Triaminic Softchews Cold and AllergyNovartis Consumer Health Canada Inc.
Triaminic Softchews Cough and ColdNovartis Consumer Health Canada Inc.
Triaminic Total Cold With Cough & Fever ReliefNovartis Consumer Health Canada Inc.
Triaminicol DM SyrupNovartis Consumer Health Canada Inc.
Tricode ArRespa Pharmaceuticals, Inc.
TussicapsECR Pharmaceuticals
Tussilyn DMLes Laboratoires Vachon Inc.
Tussionex PennkineticUnither Manufacturing, LLC
Tylenol AllergyMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Tylenol Cold Nightime Rapid ReleaseMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Tylenol Cold Plus Flu Severe Day/nightJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division
Tylenol Complete Cold, Cough & Flu NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Tylenol Flu NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Tylenol Sinus NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Up and Up Cold ReliefTarget Corporation
VasofrinicLaboratoires Trianon Inc
Vasofrinic DhLaboratoires Trianon Inc
Vasofrinic Plus SiropLaboratoires Trianon Inc
Vasofrinic SiropLaboratoires Trianon Inc
Vicks Alcohol Free Nyquil Cold and Flu Nighttime ReliefThe Procter & Gamble Manufacturing Company
Vicks Children's Nyquil Cold & Cough Multi-symptom ReliefProcter & Gamble Inc
Vicks Childrens Nyquil Cold and Cough Multi-symptom ReliefThe Procter & Gamble Manufacturing Company
Vicks Custom Care Cough & Cold PMProcter & Gamble Inc
Vicks Formula 44m LiqProcter & Gamble Inc
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Vicks Pediatric Formula 44m LiqProcter & Gamble Inc
VituzHawthorn Pharmaceuticals, Inc.
Wal-finate DWalgreen Company
Wal-phedWalgreen Company
Wal-phed PE Maximum StrengthWalgreen Company
Winco Foods Effervescent Cold ReliefWin Co Foods, Llc
Xl3 XtraTeresa Cecena Dba Genesis
YinchiaoTianjin Zhongxin Pharmaceutical Group Corp Ltd Longshunrong Pharmaceutical Factory
Z-tuss AcMagna Pharmaceuticals, Inc.
Zodryl Ac 25Coda Dose, Inc.
Zodryl Ac 30Coda Dose, Inc.
Zodryl Ac 40Coda Dose, Inc.
Zodryl Ac 50Coda Dose, Inc.
Zodryl Ac 60Coda Dose, Inc.
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Salts
Name/CASStructureProperties
Chlorpheniramine hydrochloride
56343-98-7
Thumb
  • InChI Key: NOXNCSQBTYNMHD-UHFFFAOYSA-N
  • Monoisotopic Mass: 310.1003541
  • Average Mass: 311.25
DBSALT001894
Chlorpheniramine maleate
113-92-8
Thumb
  • InChI Key: DBAKFASWICGISY-BTJKTKAUSA-N
  • Monoisotopic Mass: 390.1346349
  • Average Mass: 390.86
DBSALT000987
Chlorpheniramine tannate
1405-56-7
Thumb
  • InChI Key: KOOFUFFGNZKXFG-HBNMXAOGSA-N
  • Monoisotopic Mass: 1974.2966505
  • Average Mass: 1976.0
DBSALT001556
Categories
UNII3U6IO1965U
CAS number132-22-9
WeightAverage: 274.788
Monoisotopic: 274.123676325
Chemical FormulaC16H19ClN2
InChI KeySOYKEARSMXGVTM-UHFFFAOYSA-N
InChI
InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
IUPAC Name
[3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl]dimethylamine
SMILES
CN(C)CCC(C1=CC=C(Cl)C=C1)C1=CC=CC=N1
Pharmacology
IndicationFor the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.
Structured Indications
PharmacodynamicsIn allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Mechanism of actionChlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
TargetKindPharmacological actionActionsOrganismUniProt ID
Histamine H1 receptorProteinyes
antagonist
HumanP35367 details
Sodium-dependent serotonin transporterProteinunknown
inhibitor
HumanP31645 details
Sodium-dependent noradrenaline transporterProteinunknown
inhibitor
HumanP23975 details
Sodium-dependent dopamine transporterProteinunknown
inhibitor
HumanQ01959 details
Related Articles
AbsorptionWell absorbed in the gastrointestinal tract.
Volume of distributionNot Available
Protein binding72%
Metabolism

Primarily hepatic via Cytochrome P450 (CYP450) enzymes.

Route of eliminationNot Available
Half life21-27 hours
ClearanceNot Available
ToxicityOral LD50 (rat): 306 mg/kg; Oral LD50 (mice): 130 mg/kg; Oral LD50 (guinea pig): 198 mg/kg [Registry of Toxic Effects of Chemical Substances. Ed. D. Sweet, US Dept. of Health & Human Services: Cincinatti, 2010.] Also a mild reproductive toxin to women of childbearing age.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with 1,1,1,2 Tetrafluoroethane.Investigational
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Chlorphenamine.Experimental, Illicit
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may decrease the sedative activities of Chlorphenamine.Experimental, Illicit
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Chlorphenamine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Chlorphenamine.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Chlorphenamine.Experimental
AbirateroneThe serum concentration of Chlorphenamine can be increased when it is combined with Abiraterone.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Chlorphenamine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Chlorphenamine.Approved
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Chlorphenamine.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Chlorphenamine.Approved, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Chlorphenamine.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Chlorphenamine.Approved, Illicit
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Chlorphenamine.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chlorphenamine.Approved, Illicit, Investigational
AmiodaroneThe metabolism of Chlorphenamine can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Chlorphenamine.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Chlorphenamine.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Chlorphenamine.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Chlorphenamine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Chlorphenamine.Experimental
AmphetamineAmphetamine may decrease the sedative activities of Chlorphenamine.Approved, Illicit
AprepitantThe serum concentration of Chlorphenamine can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Chlorphenamine.Approved, Investigational
ArtemetherThe metabolism of Chlorphenamine can be decreased when combined with Artemether.Approved
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Chlorphenamine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Chlorphenamine.Approved
AtazanavirThe metabolism of Chlorphenamine can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Chlorphenamine can be decreased when combined with Atomoxetine.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Chlorphenamine.Vet Approved
AzelastineChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Chlorphenamine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Chlorphenamine.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Chlorphenamine.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Chlorphenamine.Approved
BenzphetamineBenzphetamine may decrease the sedative activities of Chlorphenamine.Approved, Illicit
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Chlorphenamine.Approved
Benzylpenicilloyl PolylysineChlorphenamine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.Approved
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Chlorphenamine.Approved
BetaxololThe metabolism of Chlorphenamine can be decreased when combined with Betaxolol.Approved
BexaroteneThe serum concentration of Chlorphenamine can be decreased when it is combined with Bexarotene.Approved, Investigational
BoceprevirThe metabolism of Chlorphenamine can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Chlorphenamine can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Chlorphenamine can be decreased when it is combined with Bosentan.Approved, Investigational
BrexpiprazoleThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Brimonidine is combined with Chlorphenamine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Chlorphenamine.Approved, Illicit
BrompheniramineThe risk or severity of adverse effects can be increased when Brompheniramine is combined with Chlorphenamine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Chlorphenamine.Approved, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chlorphenamine.Approved, Investigational
BuprenorphineChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Chlorphenamine can be decreased when combined with Bupropion.Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Chlorphenamine.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Chlorphenamine.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Chlorphenamine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Chlorphenamine.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Chlorphenamine.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Chlorphenamine.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Chlorphenamine.Approved, Illicit, Vet Approved
CarbamazepineThe metabolism of Chlorphenamine can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Carbinoxamine is combined with Chlorphenamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorphenamine.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Chlorphenamine.Approved
CelecoxibThe metabolism of Chlorphenamine can be decreased when combined with Celecoxib.Approved, Investigational
CeritinibThe serum concentration of Chlorphenamine can be increased when it is combined with Ceritinib.Approved
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Chlorphenamine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Chlorphenamine.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chlorphenamine.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Chlorphenamine.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Chlorphenamine.Approved
ChloroquineThe metabolism of Chlorphenamine can be decreased when combined with Chloroquine.Approved, Vet Approved
ChlorphentermineChlorphentermine may decrease the sedative activities of Chlorphenamine.Illicit, Withdrawn
ChlorpromazineThe metabolism of Chlorphenamine can be decreased when combined with Chlorpromazine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Chlorphenamine.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Chlorphenamine.Approved
CholecalciferolThe metabolism of Chlorphenamine can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CimetidineThe metabolism of Chlorphenamine can be decreased when combined with Cimetidine.Approved
CinacalcetThe metabolism of Chlorphenamine can be decreased when combined with Cinacalcet.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Chlorphenamine.Approved, Vet Approved
CitalopramThe metabolism of Chlorphenamine can be decreased when combined with Citalopram.Approved
ClarithromycinThe metabolism of Chlorphenamine can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Chlorphenamine can be decreased when combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Clidinium is combined with Chlorphenamine.Approved
ClobazamThe metabolism of Chlorphenamine can be decreased when combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Chlorphenamine.Investigational
ClomipramineThe metabolism of Chlorphenamine can be decreased when combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Clonazepam is combined with Chlorphenamine.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Chlorphenamine.Approved
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Chlorphenamine.Approved, Illicit
ClotrimazoleThe metabolism of Chlorphenamine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Chlorphenamine can be decreased when combined with Clozapine.Approved
CobicistatThe serum concentration of Chlorphenamine can be increased when it is combined with Cobicistat.Approved
CocaineThe metabolism of Chlorphenamine can be decreased when combined with Cocaine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Chlorphenamine.Approved, Illicit
ConivaptanThe serum concentration of Chlorphenamine can be increased when it is combined with Conivaptan.Approved, Investigational
CrizotinibThe metabolism of Chlorphenamine can be decreased when combined with Crizotinib.Approved
CyclizineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Chlorphenamine.Approved
CyclosporineThe metabolism of Chlorphenamine can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Chlorphenamine.Approved
DabrafenibThe serum concentration of Chlorphenamine can be decreased when it is combined with Dabrafenib.Approved
DantroleneThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Chlorphenamine.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Dapoxetine.Investigational
DarifenacinThe metabolism of Chlorphenamine can be decreased when combined with Darifenacin.Approved, Investigational
DarunavirThe serum concentration of Chlorphenamine can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Chlorphenamine can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of Chlorphenamine can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Chlorphenamine can be decreased when combined with Delavirdine.Approved
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Chlorphenamine.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Chlorphenamine.Approved
DesipramineThe metabolism of Chlorphenamine can be decreased when combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Chlorphenamine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Chlorphenamine.Vet Approved
DexamethasoneThe serum concentration of Chlorphenamine can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Chlorphenamine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Chlorphenamine.Approved, Vet Approved
DextroamphetamineDextroamphetamine may decrease the sedative activities of Chlorphenamine.Approved, Illicit
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Chlorphenamine.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Chlorphenamine.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Chlorphenamine.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Chlorphenamine.Approved, Illicit, Vet Approved
DiethylpropionDiethylpropion may decrease the sedative activities of Chlorphenamine.Approved, Illicit
DifenoxinThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Chlorphenamine.Approved, Illicit
DihydroergotamineThe metabolism of Chlorphenamine can be decreased when combined with Dihydroergotamine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Chlorphenamine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Chlorphenamine.Experimental, Illicit
DiltiazemThe metabolism of Chlorphenamine can be decreased when combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Chlorphenamine.Approved
DiphenhydramineThe metabolism of Chlorphenamine can be decreased when combined with Diphenhydramine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Chlorphenamine.Approved, Illicit
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Chlorphenamine.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Doxepin.Approved
DoxycyclineThe metabolism of Chlorphenamine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Chlorphenamine.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.Approved, Illicit
DronedaroneThe metabolism of Chlorphenamine can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Chlorphenamine.Experimental, Illicit
DuloxetineThe metabolism of Chlorphenamine can be decreased when combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Chlorphenamine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Chlorphenamine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Chlorphenamine.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Ecopipam.Investigational
EfavirenzThe serum concentration of Chlorphenamine can be decreased when it is combined with Efavirenz.Approved, Investigational
EliglustatThe metabolism of Chlorphenamine can be decreased when combined with Eliglustat.Approved
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Chlorphenamine.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Chlorphenamine.Approved, Investigational
EnzalutamideThe serum concentration of Chlorphenamine can be decreased when it is combined with Enzalutamide.Approved
ErythromycinThe metabolism of Chlorphenamine can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Chlorphenamine can be decreased when it is combined with Eslicarbazepine acetate.Approved
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Chlorphenamine.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Chlorphenamine.Approved
EthanolChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Chlorphenamine.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Ethosuximide is combined with Chlorphenamine.Approved
EthotoinThe risk or severity of adverse effects can be increased when Ethotoin is combined with Chlorphenamine.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Chlorphenamine.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Chlorphenamine.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Chlorphenamine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Chlorphenamine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Chlorphenamine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Chlorphenamine.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Chlorphenamine.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Chlorphenamine.Illicit, Vet Approved
EtravirineThe serum concentration of Chlorphenamine can be decreased when it is combined with Etravirine.Approved
EzogabineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Felbamate is combined with Chlorphenamine.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Chlorphenamine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Chlorphenamine.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Chlorphenamine.Approved
FexofenadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Chlorphenamine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Flibanserin.Approved
FluconazoleThe metabolism of Chlorphenamine can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Chlorphenamine.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Chlorphenamine.Approved, Illicit
FluoxetineThe metabolism of Chlorphenamine can be decreased when combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Chlorphenamine.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Chlorphenamine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Chlorphenamine.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Chlorphenamine.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Chlorphenamine.Approved
FluvoxamineThe metabolism of Chlorphenamine can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Chlorphenamine can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Chlorphenamine can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Chlorphenamine.Approved
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Chlorphenamine.Approved, Illicit
Fusidic AcidThe serum concentration of Chlorphenamine can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Chlorphenamine.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Chlorphenamine.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Chlorphenamine.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Guanfacine is combined with Chlorphenamine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Chlorphenamine.Approved, Illicit, Withdrawn
HaloperidolThe metabolism of Chlorphenamine can be decreased when combined with Haloperidol.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Chlorphenamine.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Chlorphenamine.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Chlorphenamine.Approved
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Chlorphenamine.Approved, Investigational
HydrocodoneChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Chlorphenamine.Approved, Illicit
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may decrease the sedative activities of Chlorphenamine.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.Approved
IdelalisibThe serum concentration of Chlorphenamine can be increased when it is combined with Idelalisib.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Iloperidone.Approved
ImatinibThe metabolism of Chlorphenamine can be decreased when combined with Imatinib.Approved
ImipramineThe metabolism of Chlorphenamine can be decreased when combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Indalpine.Investigational, Withdrawn
IndinavirThe metabolism of Chlorphenamine can be decreased when combined with Indinavir.Approved
IsavuconazoniumThe metabolism of Chlorphenamine can be decreased when combined with Isavuconazonium.Approved, Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Chlorphenamine.Approved, Vet Approved
IsoniazidThe metabolism of Chlorphenamine can be decreased when combined with Isoniazid.Approved
IsradipineThe metabolism of Chlorphenamine can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Chlorphenamine can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Chlorphenamine can be increased when it is combined with Ivacaftor.Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Chlorphenamine.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Chlorphenamine.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Chlorphenamine.Approved
KetoconazoleThe metabolism of Chlorphenamine can be decreased when combined with Ketoconazole.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Chlorphenamine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Chlorphenamine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Chlorphenamine.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Chlorphenamine.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chlorphenamine.Approved, Vet Approved
LisdexamfetamineLisdexamfetamine may decrease the sedative activities of Chlorphenamine.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Chlorphenamine.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Chlorphenamine.Illicit
LopinavirThe metabolism of Chlorphenamine can be decreased when combined with Lopinavir.Approved
LoratadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Chlorphenamine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlorphenamine.Approved
LorcaserinThe metabolism of Chlorphenamine can be decreased when combined with Lorcaserin.Approved
LovastatinThe metabolism of Chlorphenamine can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Chlorphenamine.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Chlorphenamine.Investigational
LuliconazoleThe serum concentration of Chlorphenamine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Chlorphenamine can be increased when combined with Lumacaftor.Approved
LumefantrineThe metabolism of Chlorphenamine can be decreased when combined with Lumefantrine.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Chlorphenamine.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Chlorphenamine.Approved
MeclizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Chlorphenamine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Chlorphenamine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Chlorphenamine.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Chlorphenamine.Approved
MephedroneMephedrone may decrease the sedative activities of Chlorphenamine.Investigational
MephentermineMephentermine may decrease the sedative activities of Chlorphenamine.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Chlorphenamine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Chlorphenamine.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Chlorphenamine.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Chlorphenamine.Approved
MethadoneThe metabolism of Chlorphenamine can be decreased when combined with Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chlorphenamine.Approved, Illicit
MethamphetamineMethamphetamine may decrease the sedative activities of Chlorphenamine.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Chlorphenamine.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Chlorphenamine.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Chlorphenamine.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Chlorphenamine.Approved
MethotrimeprazineChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Chlorphenamine.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Methsuximide.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Chlorphenamine.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Chlorphenamine.Approved, Investigational
MetyrosineChlorphenamine may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Chlorphenamine.Approved, Illicit
MifepristoneThe serum concentration of Chlorphenamine can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.Approved, Investigational
MirabegronThe metabolism of Chlorphenamine can be decreased when combined with Mirabegron.Approved
MirtazapineChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of Chlorphenamine can be decreased when it is combined with Mitotane.Approved
MMDAMMDA may decrease the sedative activities of Chlorphenamine.Experimental, Illicit
ModafinilThe serum concentration of Chlorphenamine can be decreased when it is combined with Modafinil.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Chlorphenamine.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Chlorphenamine.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.Approved, Investigational
NafcillinThe serum concentration of Chlorphenamine can be decreased when it is combined with Nafcillin.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Chlorphenamine.Approved
NefazodoneThe metabolism of Chlorphenamine can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Chlorphenamine can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Chlorphenamine can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Chlorphenamine can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Chlorphenamine can be decreased when combined with Nicardipine.Approved
NilotinibThe metabolism of Chlorphenamine can be decreased when combined with Nilotinib.Approved, Investigational
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Chlorphenamine.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Chlorphenamine.Approved, Vet Approved
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Chlorphenamine.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Chlorphenamine.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Chlorphenamine.Approved, Investigational
OlaparibThe metabolism of Chlorphenamine can be decreased when combined with Olaparib.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Chlorphenamine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Chlorphenamine.Approved
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Chlorphenamine.Approved, Illicit
OrphenadrineChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Chlorphenamine.Investigational
OsimertinibThe serum concentration of Chlorphenamine can be increased when it is combined with Osimertinib.Approved
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Chlorphenamine.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Chlorphenamine.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Chlorphenamine.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chlorphenamine.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Chlorphenamine.Approved, Investigational, Vet Approved
PalbociclibThe serum concentration of Chlorphenamine can be increased when it is combined with Palbociclib.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Chlorphenamine.Approved
PanobinostatThe serum concentration of Chlorphenamine can be increased when it is combined with Panobinostat.Approved, Investigational
ParaldehydeChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe metabolism of Chlorphenamine can be decreased when combined with Paroxetine.Approved, Investigational
Peginterferon alfa-2bThe serum concentration of Chlorphenamine can be decreased when it is combined with Peginterferon alfa-2b.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Chlorphenamine.Approved, Vet Approved
PentobarbitalThe metabolism of Chlorphenamine can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.Approved
PerazineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Chlorphenamine.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Chlorphenamine.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Chlorphenamine.Approved
PhenobarbitalThe metabolism of Chlorphenamine can be increased when combined with Phenobarbital.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Chlorphenamine.Approved
PhenterminePhentermine may decrease the sedative activities of Chlorphenamine.Approved, Illicit
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Chlorphenamine.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Chlorphenamine.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Chlorphenamine.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Pomalidomide.Approved
PosaconazoleThe metabolism of Chlorphenamine can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexoleChlorphenamine may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Chlorphenamine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Chlorphenamine.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlorphenamine.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Chlorphenamine.Approved
PrimidoneThe metabolism of Chlorphenamine can be increased when combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Chlorphenamine.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Chlorphenamine.Approved, Vet Approved
PromazineThe metabolism of Chlorphenamine can be decreased when combined with Promazine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Chlorphenamine.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Chlorphenamine.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Chlorphenamine.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Chlorphenamine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Chlorphenamine.Approved
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Chlorphenamine.Investigational
PseudoephedrinePseudoephedrine may decrease the sedative activities of Chlorphenamine.Approved
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Chlorphenamine.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Chlorphenamine.Approved
QuinidineThe metabolism of Chlorphenamine can be decreased when combined with Quinidine.Approved
QuinineThe metabolism of Chlorphenamine can be decreased when combined with Quinine.Approved
RacloprideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Ramelteon is combined with Chlorphenamine.Approved, Investigational
RanolazineThe metabolism of Chlorphenamine can be decreased when combined with Ranolazine.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Chlorphenamine.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Chlorphenamine.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Chlorphenamine.Approved
RifabutinThe metabolism of Chlorphenamine can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Chlorphenamine can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Chlorphenamine can be increased when combined with Rifapentine.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Chlorphenamine.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Ritanserin.Investigational
RitobegronRitobegron may decrease the sedative activities of Chlorphenamine.Investigational
RitonavirThe metabolism of Chlorphenamine can be decreased when combined with Ritonavir.Approved, Investigational
RolapitantThe metabolism of Chlorphenamine can be decreased when combined with Rolapitant.Approved
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Chlorphenamine.Vet Approved
RopiniroleChlorphenamine may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Chlorphenamine.Approved
RotigotineChlorphenamine may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Chlorphenamine.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Chlorphenamine.Experimental
Sage 547The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Sage 547.Investigational
SaquinavirThe metabolism of Chlorphenamine can be decreased when combined with Saquinavir.Approved, Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Chlorphenamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Chlorphenamine.Approved, Vet Approved
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Chlorphenamine.Approved, Withdrawn
SertralineThe metabolism of Chlorphenamine can be decreased when combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Chlorphenamine.Approved, Vet Approved
SildenafilThe metabolism of Chlorphenamine can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Chlorphenamine can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Chlorphenamine can be increased when it is combined with Simeprevir.Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.Approved
St. John's WortThe serum concentration of Chlorphenamine can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Chlorphenamine can be increased when it is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Chlorphenamine.Approved, Investigational
SulfisoxazoleThe metabolism of Chlorphenamine can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Chlorphenamine.Approved
SuvorexantChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Tasimelteon.Approved
TelaprevirThe metabolism of Chlorphenamine can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Chlorphenamine can be decreased when combined with Telithromycin.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Chlorphenamine.Approved
TerbinafineThe metabolism of Chlorphenamine can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Chlorphenamine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Chlorphenamine.Investigational
ThalidomideChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Chlorphenamine.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Chlorphenamine.Approved, Vet Approved
ThioridazineChlorphenamine may increase the arrhythmogenic activities of Thioridazine.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Chlorphenamine.Approved
TiagabineThe risk or severity of adverse effects can be increased when Tiagabine is combined with Chlorphenamine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Tiapride.Investigational
TiclopidineThe metabolism of Chlorphenamine can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Chlorphenamine.Vet Approved
TipranavirThe metabolism of Chlorphenamine can be decreased when combined with Tipranavir.Approved, Investigational
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Chlorphenamine.Approved
TocilizumabThe serum concentration of Chlorphenamine can be decreased when it is combined with Tocilizumab.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Chlorphenamine.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Chlorphenamine.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Chlorphenamine.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Chlorphenamine.Experimental
TranylcypromineThe metabolism of Chlorphenamine can be decreased when combined with Tranylcypromine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Chlorphenamine.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Chlorphenamine.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Chlorphenamine.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Chlorphenamine.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Chlorphenamine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Chlorphenamine.Approved
Uc1010The risk or severity of adverse effects can be increased when Chlorphenamine is combined with Uc1010.Investigational
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Chlorphenamine.Approved, Investigational
VenlafaxineThe metabolism of Chlorphenamine can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Chlorphenamine can be decreased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Vigabatrin is combined with Chlorphenamine.Approved
VoriconazoleThe metabolism of Chlorphenamine can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Chlorphenamine.Approved
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Chlorphenamine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Chlorphenamine.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Chlorphenamine is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Chlorphenamine can be decreased when combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Chlorphenamine.Vet Approved
ZolpidemChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Zonisamide is combined with Chlorphenamine.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Chlorphenamine.Approved
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Chlorphenamine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Chlorphenamine.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Take with food.
References
Synthesis Reference

Anil M. Salpekar, John Johnson, “Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom.” U.S. Patent US4631284, issued April, 1975.

US4631284
General References
  1. MSDS [Link]
External Links
ATC CodesR06AB54R06AB04
AHFS Codes
  • 04:04.20
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (72.8 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9754
Blood Brain Barrier+0.962
Caco-2 permeable+0.8749
P-glycoprotein substrateSubstrate0.6136
P-glycoprotein inhibitor INon-inhibitor0.8782
P-glycoprotein inhibitor IINon-inhibitor0.9376
Renal organic cation transporterInhibitor0.7916
CYP450 2C9 substrateNon-substrate0.8026
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateSubstrate0.6472
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9096
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.9023
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7501
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.9183
BiodegradationNot ready biodegradable1.0
Rat acute toxicity3.3361 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8702
hERG inhibition (predictor II)Inhibitor0.7145
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
GranuleOral
Capsule, gelatin coatedOral
Capsule, liquid filledOral
Tablet, effervescentOral
Granule, effervescentOral
Powder, for solutionOral
SyrupOral2 mg/5mL
Liquid; tabletIntramuscular; Oral; Subcutaneous
Liquid; tabletOral; Parenteral
Granule, for solutionOral
LiquidTopical
Tablet, chewableOral
LiquidOral
SolutionOral
Tablet, extended releaseOral12 mg/1
Tablet, extended releaseOral12 mg
Kit; tablet; tablet, extended releaseOral
TabletOral12 mg
Tablet, film coated, extended releaseOral12 mg/1
LiquidIntramuscular; Intravenous; Subcutaneous10 mg
SyrupOral2.5 mg
Tablet, extended releaseOral
Kit; tabletOral
KitOral
Kit
Tablet, sugar coatedOral
LozengeOral2 mg/1
Kit; powder, for solutionOral
LiquidOral2 mL/mL
LiquidOral2 mg/5mL
Tablet, coatedOral4 mg/1
Kit; powderOral
TabletOral4 mg/1
Tablet, film coatedOral
CapsuleOral1.25 mg/1
Suspension, extended releaseOral
Capsule, delayed release pelletsOral
CapsuleOral
Tablet, multilayerOral
TabletOral4 mg
PowderOral
TabletOral
Tablet, coatedOral
SyrupOral
SuspensionOral
Capsule, extended releaseOral
Prices
Unit descriptionCostUnit
Ahist 12 mg tablet1.1USD tablet
Myci chlor-tan 8 mg caplet0.75USD caplet
Chlorpheniramine powder0.67USD g
Chlor-trimeton allergy0.31USD each
Chlor-trimeton 8 mg repetab0.24USD tablet
Aller-chlor 4 mg tablet0.06USD tablet
Pediacare allergy solution0.05USD ml
Allergy 4 mg tablet0.04USD tablet
Chlorpheniramine 4 mg tablet0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6248363 No1999-11-232019-11-23Us
US6383471 No1999-04-062019-04-06Us
US7863287 No2007-02-282027-02-28Us
US8062667 No2009-03-292029-03-29Us
US8790700 No2007-03-152027-03-15Us
US9066942 No2012-01-032032-01-03Us
US9107921 No2012-01-032032-01-03Us
Properties
StateLiquid
Experimental Properties
PropertyValueSource
boiling point142 °CNot Available
water solubility5500 mg/L (at 37 °C)BEILSTEIN
logP3.38HANSCH,C ET AL. (1995)
pKa9.13 (at 25 °C)PERRIN,DD (1965)
Predicted Properties
PropertyValueSource
Water Solubility0.0519 mg/mLALOGPS
logP3.74ALOGPS
logP3.58ChemAxon
logS-3.7ALOGPS
pKa (Strongest Basic)9.47ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area16.13 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity80.85 m3·mol-1ChemAxon
Polarizability30.82 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-01b9-3900000000-ea4ccfd2afe05f49fc7aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-004i-0090000000-9e46eb080de95d4f8f8eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-014i-1920000000-d2d2acf559d9070a1d47View in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (Unknown) , Positivesplash10-0zfr-6190000000-2ca3230cde716588805eView in MoNA
MSMass Spectrum (Electron Ionization)splash10-0zfr-6490000000-8e58cd1c686f23a7dac6View in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as pheniramines. These are compounds containing a pheniramine moiety, which is structurally characterized by the presence of a 2-benzylpyridine linked to an dimethyl(propyl)amine to form a dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine skeleton.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPyridines and derivatives
Sub ClassPheniramines
Direct ParentPheniramines
Alternative Parents
Substituents
  • Pheniramine
  • Phenylpropylamine
  • Aralkylamine
  • Halobenzene
  • Chlorobenzene
  • Benzenoid
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Tagawa M, Kano M, Okamura N, Higuchi M, Matsuda M, Mizuki Y, Arai H, Iwata R, Fujii T, Komemushi S, Ido T, Itoh M, Sasaki H, Watanabe T, Yanai K: Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine. Br J Clin Pharmacol. 2001 Nov;52(5):501-9. [PubMed:11736858 ]
  3. Salata JJ, Jurkiewicz NK, Wallace AA, Stupienski RF 3rd, Guinosso PJ Jr, Lynch JJ Jr: Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine. Circ Res. 1995 Jan;76(1):110-9. [PubMed:8001268 ]
  4. Hasenohrl RU, Kuhlen A, Frisch C, Galosi R, Brandao ML, Huston JP: Comparison of intra-accumbens injection of histamine with histamine H1-receptor antagonist chlorpheniramine in effects on reinforcement and memory parameters. Behav Brain Res. 2001 Oct 15;124(2):203-11. [PubMed:11640974 ]
  5. Yasuda SU, Wellstein A, Likhari P, Barbey JT, Woosley RL: Chlorpheniramine plasma concentration and histamine H1-receptor occupancy. Clin Pharmacol Ther. 1995 Aug;58(2):210-20. [PubMed:7648771 ]
  6. Nicholson AN, Pascoe PA, Turner C, Ganellin CR, Greengrass PM, Casy AF, Mercer AD: Sedation and histamine H1-receptor antagonism: studies in man with the enantiomers of chlorpheniramine and dimethindene. Br J Pharmacol. 1991 Sep;104(1):270-6. [PubMed:1686208 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Serotonin:sodium symporter activity
Specific Function:
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin an...
Gene Name:
SLC6A4
Uniprot ID:
P31645
Molecular Weight:
70324.165 Da
References
  1. Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. [PubMed:9537821 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Norepinephrine:sodium symporter activity
Specific Function:
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A2
Uniprot ID:
P23975
Molecular Weight:
69331.42 Da
References
  1. Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. [PubMed:9537821 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Monoamine transmembrane transporter activity
Specific Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A3
Uniprot ID:
Q01959
Molecular Weight:
68494.255 Da
References
  1. Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. [PubMed:9537821 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Hamelin BA, Bouayad A, Drolet B, Gravel A, Turgeon J: In vitro characterization of cytochrome P450 2D6 inhibition by classic histamine H1 receptor antagonists. Drug Metab Dispos. 1998 Jun;26(6):536-9. [PubMed:9616188 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Quaternary ammonium group transmembrane transporter activity
Specific Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:
SLC22A2
Uniprot ID:
O15244
Molecular Weight:
62579.99 Da
References
  1. Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. [PubMed:11758759 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular Weight:
61153.345 Da
References
  1. Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. [PubMed:11758759 ]
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Drug created on June 13, 2005 07:24 / Updated on December 09, 2016 02:40