Displaying drugs 2976 - 3000 of 3002 in total
Natalizumab
Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA reintroduced the drug to the...
Approved
Investigational
Matched Synonyms: … Anti-alpha4 integrin …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Olanzapine
Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug interactions. Olanzapine very closely resembles clozapine and only differs by...
Approved
Investigational
Matched Description: … [A177011] Olanzapine very closely resembles [clozapine] and only differs by two additional methyl groups ... and the absence of a chloride moiety. ... [A176996] The second-generation antipsychotics were introduced in the 90s and quickly gained traction …
Matched Mixtures name: … Olanzapine and Fluoxetine ... Olanzapine and Fluoxetine ... Olanzapine and Fluoxetine …
Matched Categories: … olanzapine and samidorphan ... Diazepines, Oxazepines, Thiazepines and Oxepines ... Adrenergic alpha-Antagonists ... Adrenergic alpha-1 Receptor Antagonists …
Matched Products: … AS-PINEKS 15 MG AĞIZDA DAĞILABILIR TABLET , TABLET, 28 ADET ... AS-PINEKS 20 MG AĞIZDA DAĞILABILIR TABLET , TABLET, 28 ADET ... AS-PINEKS 5 MG AĞIZDA DAĞILABILIR TABLET , TABLET, 28 ADET …
Matched Mixtures name: … Olanzapine and Fluoxetine ... Olanzapine and Fluoxetine ... Olanzapine and Fluoxetine …
Matched Categories: … olanzapine and samidorphan ... Diazepines, Oxazepines, Thiazepines and Oxepines ... Adrenergic alpha-Antagonists ... Adrenergic alpha-1 Receptor Antagonists …
Matched Products: … AS-PINEKS 15 MG AĞIZDA DAĞILABILIR TABLET , TABLET, 28 ADET ... AS-PINEKS 20 MG AĞIZDA DAĞILABILIR TABLET , TABLET, 28 ADET ... AS-PINEKS 5 MG AĞIZDA DAĞILABILIR TABLET , TABLET, 28 ADET …
4-O-(4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Beta-D-Lyxo-Hexopyranosyl)-Alpha-D-Erythro-Hexopyranose
Experimental
Matched Name: … -Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Beta-D-Lyxo-Hexopyranosyl)-Alpha-D-Erythro-Hexopyranose …
Betaine
Betaine is a methyl group donor that functions in the normal metabolic cycle of methionine. It is a naturally occurring choline derivative commonly ingested through diet, with a role in regulating cellular hydration and maintaining cell function.[A252235,A252240] Homocystinuria is an inherited disorder that leads to the accumulation of homocysteine in...
Approved
Investigational
Nutraceutical
Matched Synonyms: … Acidol …
Matched Description: … in plasma and urine. ... occurring choline derivative commonly ingested through diet, with a role in regulating cellular hydration and ... levels, patients can be treated with vitamin B6 ([pyridoxine]), vitamin B12 ([cobalamin]), [folate] and …
Matched Mixtures name: … Glutamic Acid Pepsin and Betaine Tablets ... Betaine HCl and Pepsin ... Rocky Mountain Multiple Vit and Min Mega Tab …
Matched Categories: … Amino Acids and Derivatives ... Alimentary Tract and Metabolism ... Acid Preparations …
Matched Description: … in plasma and urine. ... occurring choline derivative commonly ingested through diet, with a role in regulating cellular hydration and ... levels, patients can be treated with vitamin B6 ([pyridoxine]), vitamin B12 ([cobalamin]), [folate] and …
Matched Mixtures name: … Glutamic Acid Pepsin and Betaine Tablets ... Betaine HCl and Pepsin ... Rocky Mountain Multiple Vit and Min Mega Tab …
Matched Categories: … Amino Acids and Derivatives ... Alimentary Tract and Metabolism ... Acid Preparations …
Candesartan cilexetil
Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is administered orally as the prodrug, candesartan cilexetil, which is rapidly converted to its active metabolite, candesartan, during absorption in the gastrointestinal tract. Candesartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone...
Approved
Matched Description: … RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and ... an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and ... Candesartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and …
Matched Mixtures name: … Zinda-candesartan/hydrochlorothiazide ... Zinda-candesartan/hydrochlorothiazide ... Candesartan Cilexetil and Hydrochlorothiazide …
Matched Categories: … Angiotensin II Antagonists and Diuretics …
Matched Products: … Zinda-candesartan …
Matched Mixtures name: … Zinda-candesartan/hydrochlorothiazide ... Zinda-candesartan/hydrochlorothiazide ... Candesartan Cilexetil and Hydrochlorothiazide …
Matched Categories: … Angiotensin II Antagonists and Diuretics …
Matched Products: … Zinda-candesartan …
H3B-8800
H3B-8800 is a novel spliceosome inhibitor developed by H3 Biomedicine . It offers the benefit of preferentially killing spliceosome-mutant cancer cells whereas other splicesome inhibitors, such as the pladienolide analogue E7107, show no such preferential targeting . H3B-8800 was granted orphan drug status by the FDA in August 2017 and...
Investigational
Matched Synonyms: … 1-PIPERAZINECARBOXYLIC ACID, 4-METHYL-, (2S,3S,4E,6S,7R,10R)-7,10-DIHYDROXY-3,7-DIMETHYL-2-((1E,3E,5R …
Matched Description: … of acute myelogenous leukemia and chronic myelomonocytic leukemia [L2551]. ... H3B-8800 was granted orphan drug status by the FDA in August 2017 and is in clinical trials for the treatment …
Matched Description: … of acute myelogenous leukemia and chronic myelomonocytic leukemia [L2551]. ... H3B-8800 was granted orphan drug status by the FDA in August 2017 and is in clinical trials for the treatment …
Cinrebafusp alfa
Investigational
Matched Synonyms: … ) (HUMAN-MUS MUSCULUS MONOCLONAL PRS-343 .GAMMA.4-CHAIN) FUSION PROTEIN PEPTIDE (SYNTHETIC 15-AMINO ACID …
7-((Carboxy(4-Hydroxyphenyl)Acetyl)Amino)-7-Methoxy-(3-((1-Methyl-1h-Tetrazol-5-Yl)Thio)Methyl)-8-Oxo-5-Oxa-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
Experimental
Matched Name: … Methoxy-(3-((1-Methyl-1h-Tetrazol-5-Yl)Thio)Methyl)-8-Oxo-5-Oxa-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid …
Matched Iupac: … methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Iupac: … methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
4-{[(2R,3S,4R,5S)-4-(4-Chloro-2-Fluoro-Phenyl)-3-(3-Chloro-2-Fluoro-Phenyl)-4-Cyano-5-(2,2-Dimethyl-Propyl)-Pyrrolidine-2-Carbonyl]-Amino}-3-Methoxy-Benzoic Acid
Experimental
Matched Name: … Chloro-2-Fluoro-Phenyl)-4-Cyano-5-(2,2-Dimethyl-Propyl)-Pyrrolidine-2-Carbonyl]-Amino}-3-Methoxy-Benzoic Acid …
Citalopram
Citalopram is an antidepressant belonging to the class of selective serotonin-reuptake inhibitors (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] Citalopram enhances serotonergic transmission through the...
Approved
Matched Description: … [A261316,A14720] Specifically, it has a very minimal effect on dopamine and norepinephrine transportation ... It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing ... and virtually no affinity for muscarinic, histaminergic, or GABAergic receptors. …
Matched Products: … RICAP …
Matched Products: … RICAP …
(4aS,4bR,10bS,12aS)-12a-methyl-1,3-dioxo-2-(pyridin-3-ylmethyl)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinolin-8-yl sulfamate
Experimental
Matched Name: … dioxo-2-(pyridin-3-ylmethyl)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinolin-8-yl sulfamate …
Matched Iupac: … 2-[(pyridin-3-yl)methyl]-1H,2H,3H,4H,4aH,4bH,5H,6H,10bH,11H,12H,12aH-naphtho[2,1-f]isoquinolin-8-yl sulfamate …
Matched Iupac: … 2-[(pyridin-3-yl)methyl]-1H,2H,3H,4H,4aH,4bH,5H,6H,10bH,11H,12H,12aH-naphtho[2,1-f]isoquinolin-8-yl sulfamate …
(4S)-5-[[(2S)-1-[[(2S)-1-Amino-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-4-benzamido-5-oxopentanoic acid
Experimental
Matched Name: … yl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-4-benzamido-5-oxopentanoic acid …
Matched Iupac: … ethyl]carbamoyl}-2-{4-[difluoro(phosphono)methyl]phenyl}ethyl]carbamoyl}-4-(phenylformamido)butanoic acid …
Matched Iupac: … ethyl]carbamoyl}-2-{4-[difluoro(phosphono)methyl]phenyl}ethyl]carbamoyl}-4-(phenylformamido)butanoic acid …
Dactinomycin
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin...
Approved
Investigational
Matched Synonyms: … DILACTONE ACTINOMYCIN D ACID …
Matched Description: … It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances ... Nucleic Acid Synthesis Inhibitors …
Matched Description: … It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances ... Nucleic Acid Synthesis Inhibitors …
(E)-(S)-4-[(S)-4-METHYL-2-((S)-3-METHYL-2{(S)-2-[(5-METHYL-ISOXAZOLE-3- CARBONYL)-AMINO]-PROPIONYLAMINO}-BUTYRYLAMINO)-PENTANOYLAMINO]-5-((S)-2- OXO-PYRROLIDIN-3-YL)-PENT-2-ENOIC ACID ETHYL ESTER
Experimental
Matched Name: … CARBONYL)-AMINO]-PROPIONYLAMINO}-BUTYRYLAMINO)-PENTANOYLAMINO]-5-((S)-2- OXO-PYRROLIDIN-3-YL)-PENT-2-ENOIC ACID …
(E)-(4S,6S)-8-METHYL-6-((S)-3-METHYL-2-{(S)-2-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-PROPIONYLAMINO}-BUTYRYLAMINO)-5-OXO-4-((R)-2-OXO-PYRROLIDIN-3-YLMETHYL)-NON-2-ENOIC ACID BENZYL ESTER
Experimental
Matched Name: … CARBONYL)-AMINO]-PROPIONYLAMINO}-BUTYRYLAMINO)-5-OXO-4-((R)-2-OXO-PYRROLIDIN-3-YLMETHYL)-NON-2-ENOIC ACID …
(E)-(4S,6S)-6-((S)-2-{(S)-2-[(FURAN-2-CARBONYL)-AMINO]-3-METHYL-BUTYRYLAMINO}-3-METHYL-BUTYRYLAMINO)-8-METHYL-5-OXO-4-((R)-2-OXO-PYRROLIDIN-3-YLMETHYL)-NON-2-ENOIC ACID ETHYL ESTER
Experimental
Matched Name: … METHYL-BUTYRYLAMINO}-3-METHYL-BUTYRYLAMINO)-8-METHYL-5-OXO-4-((R)-2-OXO-PYRROLIDIN-3-YLMETHYL)-NON-2-ENOIC ACID …
N-[4-([(2-Amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid
Experimental
Matched Name: … carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid …
Matched Iupac: … -5-[(phosphonooxy)methyl]oxolan-2-yl]-1H-imidazol-5-yl}prop-2-enamido]phenyl}formamido)pentanedioic acid …
Matched Iupac: … -5-[(phosphonooxy)methyl]oxolan-2-yl]-1H-imidazol-5-yl}prop-2-enamido]phenyl}formamido)pentanedioic acid …
Tadalafil
Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibitors...
Approved
Investigational
Matched Description: … that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and ... [L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. ... In contrast to other PDE5 inhibitors like [sildenafil], tadalafil has greater selectivity for PDE5 and …
Matched Categories: … 5-alpha Reductase Inhibitors ... Genito Urinary System and Sex Hormones ... ambrisentan and tadalafil ... tamsulosin and tadalafil ... finasteride and tadalafil …
Matched Products: … BIOPEN® 20 MG TABLETAS RECUBIERTAS …
Matched Categories: … 5-alpha Reductase Inhibitors ... Genito Urinary System and Sex Hormones ... ambrisentan and tadalafil ... tamsulosin and tadalafil ... finasteride and tadalafil …
Matched Products: … BIOPEN® 20 MG TABLETAS RECUBIERTAS …
4-[[(2S)-1-[[6-[(1-Amino-1-oxo-3-sulfanylpropan-2-yl)amino]-6-oxohexyl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[[2-[4-[difluoro(phosphono)methyl]phenyl]acetyl]amino]-4-oxobutanoic acid
Experimental
Matched Name: … phenyl]-1-oxopropan-2-yl]amino]-3-[[2-[4-[difluoro(phosphono)methyl]phenyl]acetyl]amino]-4-oxobutanoic acid …
Matched Iupac: … phosphono)methyl]phenyl}ethyl]carbamoyl}-3-(2-{4-[difluoro(phosphono)methyl]phenyl}acetamido)propanoic acid …
Matched Iupac: … phosphono)methyl]phenyl}ethyl]carbamoyl}-3-(2-{4-[difluoro(phosphono)methyl]phenyl}acetamido)propanoic acid …
ST-101
ST-101 is a small peptide antagonist of C/EBPβ and T-type calcium channel activator. ST101 has been used in trials studying the treatment of Essential Tremor and Alzheimer's Disease.
Investigational
Matched Synonyms: … ST-101 (D-AMINO ACID PEPTIDE) …
Matched Description: … ST-101 is a small peptide antagonist of C/EBPβ and T-type calcium channel activator. ... ST101 has been used in trials studying the treatment of Essential Tremor and Alzheimer's Disease. …
Matched Description: … ST-101 is a small peptide antagonist of C/EBPβ and T-type calcium channel activator. ... ST101 has been used in trials studying the treatment of Essential Tremor and Alzheimer's Disease. …
(2S)-2-({4-[(2S)-1-(2-Amino-4-oxo-1,4-dihydro-6-quinazolinyl)-3-{[2-({(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]tetrahydro-2-furanyl}amino)-2-oxoethyl]amino}-2-hydroxy-2-propanyl]benzoyl}ami no)pentanedioic acid
Experimental
Matched Name: … methyl]tetrahydro-2-furanyl}amino)-2-oxoethyl]amino}-2-hydroxy-2-propanyl]benzoyl}ami no)pentanedioic acid …
Matched Iupac: … phosphonooxy)methyl]oxolan-2-yl]carbamoyl}methyl)amino]-2-hydroxypropan-2-yl]phenyl}formamido)pentanedioic acid …
Matched Iupac: … phosphonooxy)methyl]oxolan-2-yl]carbamoyl}methyl)amino]-2-hydroxypropan-2-yl]phenyl}formamido)pentanedioic acid …
Metformin
Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173]
Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "insulin sensitizer", leading to a decrease in insulin...
Approved
Matched Description: … Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management ... It is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and ... [A36559]
Metformin was first approved in Canada in 1972,[A36552] and received subsequent FDA approval …
Matched Mixtures name: … Glipizide and Metformin Hydrochloride ... Glipizide and Metformin Hydrochloride ... Glipizide and Metformin Hydrochloride …
Matched Categories: … Alimentary Tract and Metabolism ... metformin and ertugliflozin ... metformin and sulfonylureas ... metformin and gemigliptin ... metformin and linagliptin …
Matched Products: … BIODID …
Matched Mixtures name: … Glipizide and Metformin Hydrochloride ... Glipizide and Metformin Hydrochloride ... Glipizide and Metformin Hydrochloride …
Matched Categories: … Alimentary Tract and Metabolism ... metformin and ertugliflozin ... metformin and sulfonylureas ... metformin and gemigliptin ... metformin and linagliptin …
Matched Products: … BIODID …
3-(alpha-D-galactopyranosyloxy)-N-(3-{4-[3-({2-[(3-{4-[3-({[3-(hexopyranosyloxy)-5-nitrophenyl]carbonyl}amino)propyl]piperazin-1-yl}propyl)amino]-3,4-dioxocyclobut-1-en-1-yl}amino)propyl]piperazin-1-yl}propyl)-5-nitrobenzamide
Experimental
Matched Name: … 3-(alpha-D-galactopyranosyloxy)-N-(3-{4-[3-({2-[(3-{4-[3-({[3-(hexopyranosyloxy)-5-nitrophenyl]carbonyl …
Quetiapine
Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high...
Approved
Matched Description: … as [clozapine] and [olanzapine]. ... , quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and ... [L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects …
Matched Categories: … Diazepines, Oxazepines, Thiazepines and Oxepines ... Adrenergic alpha-Antagonists ... Adrenergic alpha-1 Receptor Antagonists …
Matched Products: … Q-PIN ... Q-PIN XR …
Matched Categories: … Diazepines, Oxazepines, Thiazepines and Oxepines ... Adrenergic alpha-Antagonists ... Adrenergic alpha-1 Receptor Antagonists …
Matched Products: … Q-PIN ... Q-PIN XR …
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-2-O-{2-[(piperidin-3-ylmethyl)amino]ethyl}-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
Experimental
Matched Name: … 2-[(piperidin-3-ylmethyl)amino]ethyl}-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside …
Displaying drugs 2976 - 3000 of 3002 in total