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Identification
NameNatalizumab
Accession NumberDB00108  (BTD00083, BIOD00083)
TypeBiotech
GroupsApproved, Investigational
DescriptionHumanized IgG4k monoclonal antibody produced in murine myeloma cells. Natalizumab contains human framework regions and the complementarity-determining regions of a murine antibody that binds to a4-integrin. Natalizumab was voluntarily withdrawn from U.S. market because of risk of Progressive multifocal leukoencephalopathy (PML). It was returned to market July, 2006.
Protein structureDb00108
Related Articles
Protein chemical formulaNot Available
Protein average weightNot Available
SequencesNot Available
Synonyms
Anti-alpha4 integrin
Anti-VLA4
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
TysabriInjection300 mg/15mLIntravenousElan Pharmaceuticals, Inc.2004-11-232016-06-30Us
TysabriSolution300 mgIntravenousBiogen Canada Inc2006-11-21Not applicableCanada
TysabriInjection300 mg/15mLIntravenousBiogen Inc.2004-11-23Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII3JB47N2Q2P
CAS number189261-10-7
Pharmacology
IndicationFor treatment of multiple sclerosis.
Structured Indications
PharmacodynamicsIn multiple sclerosis, lesions are believed to occur when activated inflammatory cells, including T-lymphocytes, cross the blood-brain barrier (BBB). Leukocyte migration across the BBB involves interaction between adhesion molecules on inflammatory cells, and their counter-receptors present on endothelial cells of the vessel wall. The clinical effect of natalizumab in multiple sclerosis may be a secondary result of its blockade of the molecular interaction of a 4b 1-integrin expressed by inflammatory cells with VCAM-1 on vascular endothelial cells, and with CS-1 and/or osteopontin expressed by parenchymal cells in the brain. α4-integrin is required for white blood cells to move into organs, therefore, natalizumab prevents these immune cells from crossing blood vessel walls to reach affected organs thereby decreasing inflamation.
Mechanism of actionBinds to the α4-subunit of α4b 1 and α4b 7 integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the α4-mediated adhesion of leukocytes to their counter-receptor(s).
TargetKindPharmacological actionActionsOrganismUniProt ID
Integrin alpha-4Proteinyes
antibody
HumanP13612 details
Low affinity immunoglobulin gamma Fc region receptor III-BProteinunknownNot AvailableHumanO75015 details
Complement C1r subcomponentProteinunknownNot AvailableHumanP00736 details
Complement C1q subcomponent subunit AProteinunknownNot AvailableHumanP02745 details
Complement C1q subcomponent subunit BProteinunknownNot AvailableHumanP02746 details
Complement C1q subcomponent subunit CProteinunknownNot AvailableHumanP02747 details
Low affinity immunoglobulin gamma Fc region receptor III-AProteinunknownNot AvailableHumanP08637 details
High affinity immunoglobulin gamma Fc receptor IProteinunknownNot AvailableHumanP12314 details
Low affinity immunoglobulin gamma Fc region receptor II-aProteinunknownNot AvailableHumanP12318 details
Low affinity immunoglobulin gamma Fc region receptor II-bProteinunknownNot AvailableHumanP31994 details
Low affinity immunoglobulin gamma Fc region receptor II-cProteinunknownNot AvailableHumanP31995 details
Intercellular adhesion molecule 1ProteinunknownNot AvailableHumanP05362 details
Related Articles
AbsorptionNot Available
Volume of distribution
  • 5.7 ± 1.9 L [Multiple Sclerosis (MS) Patients]
  • 5.2 ± 2.8 L [Crohn’s Disease (CD) Patients]
Protein bindingNot Available
Metabolism

Most likely removed by opsonization via the reticuloendothelial system when bound to leukocytes.

Route of eliminationNot Available
Half life11 ± 4 days
Clearance
  • 16 +/- 5 mL/hour [patients with MS who did not have PML receiving the repeat IV administration of a 300 mg dose]
  • 22 +/- 22 mL/hour [Patients with Crohn’s Disease receiving the repeat IV administration of a 300 mg dose]
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
2-MethoxyethanolThe risk or severity of adverse effects can be increased when 2-Methoxyethanol is combined with Natalizumab.Experimental
9-(2-phosphonylmethoxyethyl)-2,6-diaminopurineThe risk or severity of adverse effects can be increased when 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine is combined with Natalizumab.Investigational
AbataceptThe risk or severity of adverse effects can be increased when Abatacept is combined with Natalizumab.Approved
abetimusThe risk or severity of adverse effects can be increased when abetimus is combined with Natalizumab.Investigational
ABR-215757The risk or severity of adverse effects can be increased when ABR-215757 is combined with Natalizumab.Investigational
ActeosideThe risk or severity of adverse effects can be increased when Acteoside is combined with Natalizumab.Investigational
AdalimumabThe risk or severity of adverse effects can be increased when Adalimumab is combined with Natalizumab.Approved
Adefovir DipivoxilThe risk or severity of adverse effects can be increased when Adefovir Dipivoxil is combined with Natalizumab.Approved, Investigational
AfelimomabThe risk or severity of adverse effects can be increased when Afelimomab is combined with Natalizumab.Investigational
AlefaceptThe risk or severity of adverse effects can be increased when Alefacept is combined with Natalizumab.Approved, Withdrawn
AlemtuzumabThe risk or severity of adverse effects can be increased when Alemtuzumab is combined with Natalizumab.Approved, Investigational
alicaforsenThe risk or severity of adverse effects can be increased when alicaforsen is combined with Natalizumab.Investigational
ALT-110The risk or severity of adverse effects can be increased when Natalizumab is combined with ALT-110.Investigational
AltretamineThe risk or severity of adverse effects can be increased when Altretamine is combined with Natalizumab.Approved
Amg 827The risk or severity of adverse effects can be increased when Amg 827 is combined with Natalizumab.Investigational
AmsacrineThe risk or severity of adverse effects can be increased when Amsacrine is combined with Natalizumab.Approved
AnakinraThe risk or severity of adverse effects can be increased when Anakinra is combined with Natalizumab.Approved
Anti-thymocyte Globulin (Rabbit)The risk or severity of adverse effects can be increased when Anti-thymocyte Globulin (Rabbit) is combined with Natalizumab.Approved
ApremilastThe risk or severity of adverse effects can be increased when Apremilast is combined with Natalizumab.Approved, Investigational
AzacitidineThe risk or severity of adverse effects can be increased when Azacitidine is combined with Natalizumab.Approved, Investigational
AzathioprineThe risk or severity of adverse effects can be increased when Azathioprine is combined with Natalizumab.Approved
BasiliximabThe risk or severity of adverse effects can be increased when Basiliximab is combined with Natalizumab.Approved, Investigational
BcgThe therapeutic efficacy of Bcg can be decreased when used in combination with Natalizumab.Investigational
BelataceptThe risk or severity of adverse effects can be increased when Belatacept is combined with Natalizumab.Approved
BelimumabThe risk or severity of adverse effects can be increased when Belimumab is combined with Natalizumab.Approved
BenznidazoleThe risk or severity of adverse effects can be increased when Benznidazole is combined with Natalizumab.Investigational
BetamethasoneThe risk or severity of adverse effects can be increased when Betamethasone is combined with Natalizumab.Approved, Vet Approved
BleomycinThe risk or severity of adverse effects can be increased when Bleomycin is combined with Natalizumab.Approved
BlinatumomabThe risk or severity of adverse effects can be increased when Blinatumomab is combined with Natalizumab.Approved
Brentuximab vedotinThe risk or severity of adverse effects can be increased when Brentuximab vedotin is combined with Natalizumab.Approved
BriakinumabThe risk or severity of adverse effects can be increased when Briakinumab is combined with Natalizumab.Investigational
BudesonideThe risk or severity of adverse effects can be increased when Budesonide is combined with Natalizumab.Approved
BusulfanThe risk or severity of adverse effects can be increased when Busulfan is combined with Natalizumab.Approved, Investigational
C1 Esterase Inhibitor (Human)The risk or severity of adverse effects can be increased when C1 Esterase Inhibitor (Human) is combined with Natalizumab.Approved
CabazitaxelThe risk or severity of adverse effects can be increased when Cabazitaxel is combined with Natalizumab.Approved
CanakinumabThe risk or severity of adverse effects can be increased when Canakinumab is combined with Natalizumab.Approved, Investigational
CapecitabineThe risk or severity of adverse effects can be increased when Capecitabine is combined with Natalizumab.Approved, Investigational
CarboplatinThe risk or severity of adverse effects can be increased when Carboplatin is combined with Natalizumab.Approved
CarmustineThe risk or severity of adverse effects can be increased when Carmustine is combined with Natalizumab.Approved
CastanospermineThe risk or severity of adverse effects can be increased when Castanospermine is combined with Natalizumab.Experimental
CDX-110The risk or severity of adverse effects can be increased when Natalizumab is combined with CDX-110.Investigational
Certolizumab pegolThe risk or severity of adverse effects can be increased when Certolizumab pegol is combined with Natalizumab.Approved
ChlorambucilThe risk or severity of adverse effects can be increased when Chlorambucil is combined with Natalizumab.Approved
CisplatinThe risk or severity of adverse effects can be increased when Cisplatin is combined with Natalizumab.Approved
CladribineThe risk or severity of adverse effects can be increased when Cladribine is combined with Natalizumab.Approved, Investigational
ClofarabineThe risk or severity of adverse effects can be increased when Clofarabine is combined with Natalizumab.Approved, Investigational
CorticotropinThe risk or severity of adverse effects can be increased when Corticotropin is combined with Natalizumab.Approved, Vet Approved
Cortisone acetateThe risk or severity of adverse effects can be increased when Cortisone acetate is combined with Natalizumab.Approved
CyclophosphamideThe risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Natalizumab.Approved, Investigational
CyclosporineThe risk or severity of adverse effects can be increased when Cyclosporine is combined with Natalizumab.Approved, Investigational, Vet Approved
CytarabineThe risk or severity of adverse effects can be increased when Cytarabine is combined with Natalizumab.Approved, Investigational
DacarbazineThe risk or severity of adverse effects can be increased when Dacarbazine is combined with Natalizumab.Approved, Investigational
DaclizumabThe risk or severity of adverse effects can be increased when Daclizumab is combined with Natalizumab.Approved, Investigational
DactinomycinThe risk or severity of adverse effects can be increased when Dactinomycin is combined with Natalizumab.Approved
DasatinibThe risk or severity of adverse effects can be increased when Dasatinib is combined with Natalizumab.Approved, Investigational
DaunorubicinThe risk or severity of adverse effects can be increased when Daunorubicin is combined with Natalizumab.Approved
DenosumabThe risk or severity of adverse effects can be increased when Denosumab is combined with Natalizumab.Approved
DeoxyspergualinThe risk or severity of adverse effects can be increased when Deoxyspergualin is combined with Natalizumab.Investigational
DexamethasoneThe risk or severity of adverse effects can be increased when Dexamethasone is combined with Natalizumab.Approved, Investigational, Vet Approved
Dimethyl fumarateThe risk or severity of adverse effects can be increased when Dimethyl fumarate is combined with Natalizumab.Approved, Investigational
DinutuximabThe risk or severity of adverse effects can be increased when Dinutuximab is combined with Natalizumab.Approved
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Natalizumab.Approved, Investigational
DoxifluridineThe risk or severity of adverse effects can be increased when Doxifluridine is combined with Natalizumab.Investigational
DoxorubicinThe risk or severity of adverse effects can be increased when Doxorubicin is combined with Natalizumab.Approved, Investigational
EculizumabThe risk or severity of adverse effects can be increased when Eculizumab is combined with Natalizumab.Approved, Investigational
EfalizumabThe risk or severity of adverse effects can be increased when Efalizumab is combined with Natalizumab.Approved, Investigational
EpirubicinThe risk or severity of adverse effects can be increased when Epirubicin is combined with Natalizumab.Approved
EstramustineThe risk or severity of adverse effects can be increased when Estramustine is combined with Natalizumab.Approved
EtanerceptThe risk or severity of adverse effects can be increased when Etanercept is combined with Natalizumab.Approved, Investigational
EtoposideThe risk or severity of adverse effects can be increased when Etoposide is combined with Natalizumab.Approved
EverolimusThe risk or severity of adverse effects can be increased when Everolimus is combined with Natalizumab.Approved
FingolimodThe risk or severity of adverse effects can be increased when Fingolimod is combined with Natalizumab.Approved, Investigational
FloxuridineThe risk or severity of adverse effects can be increased when Floxuridine is combined with Natalizumab.Approved
FludarabineThe risk or severity of adverse effects can be increased when Fludarabine is combined with Natalizumab.Approved
FludrocortisoneThe risk or severity of adverse effects can be increased when Fludrocortisone is combined with Natalizumab.Approved
FluorouracilThe risk or severity of adverse effects can be increased when Fluorouracil is combined with Natalizumab.Approved
G17DTThe risk or severity of adverse effects can be increased when Natalizumab is combined with G17DT.Investigational
Gallium nitrateThe risk or severity of adverse effects can be increased when Gallium nitrate is combined with Natalizumab.Approved, Investigational
GemcitabineThe risk or severity of adverse effects can be increased when Gemcitabine is combined with Natalizumab.Approved
Gemtuzumab ozogamicinThe risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Natalizumab.Approved, Investigational, Withdrawn
GI-5005The risk or severity of adverse effects can be increased when Natalizumab is combined with GI-5005.Investigational
Glatiramer AcetateThe risk or severity of adverse effects can be increased when Glatiramer Acetate is combined with Natalizumab.Approved, Investigational
GlimepirideThe risk or severity of adverse effects can be increased when Glimepiride is combined with Natalizumab.Approved
GolimumabThe risk or severity of adverse effects can be increased when Golimumab is combined with Natalizumab.Approved
GusperimusThe risk or severity of adverse effects can be increased when Gusperimus is combined with Natalizumab.Investigational
HydrocortisoneThe risk or severity of adverse effects can be increased when Hydrocortisone is combined with Natalizumab.Approved, Vet Approved
HydroxyureaThe risk or severity of adverse effects can be increased when Hydroxyurea is combined with Natalizumab.Approved
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Natalizumab.Approved
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Natalizumab.Approved
IcatibantThe risk or severity of adverse effects can be increased when Icatibant is combined with Natalizumab.Approved
IdarubicinThe risk or severity of adverse effects can be increased when Idarubicin is combined with Natalizumab.Approved
IdelalisibThe risk or severity of adverse effects can be increased when Idelalisib is combined with Natalizumab.Approved
IfosfamideThe risk or severity of adverse effects can be increased when Ifosfamide is combined with Natalizumab.Approved
ImatinibThe risk or severity of adverse effects can be increased when Imatinib is combined with Natalizumab.Approved
ImiquimodThe risk or severity of adverse effects can be increased when Imiquimod is combined with Natalizumab.Approved, Investigational
InfliximabThe risk or severity of adverse effects can be increased when Infliximab is combined with Natalizumab.Approved
INGN 201The risk or severity of adverse effects can be increased when Natalizumab is combined with INGN 201.Investigational
INGN 225The risk or severity of adverse effects can be increased when Natalizumab is combined with INGN 225.Investigational
IrinotecanThe risk or severity of adverse effects can be increased when Irinotecan is combined with Natalizumab.Approved, Investigational
L-PhenylalanineThe risk or severity of adverse effects can be increased when L-Phenylalanine is combined with Natalizumab.Approved, Nutraceutical
LeflunomideThe risk or severity of adverse effects can be increased when Leflunomide is combined with Natalizumab.Approved, Investigational
LenalidomideThe risk or severity of adverse effects can be increased when Lenalidomide is combined with Natalizumab.Approved
LisofyllineThe risk or severity of adverse effects can be increased when Lisofylline is combined with Natalizumab.Investigational
LomustineThe risk or severity of adverse effects can be increased when Lomustine is combined with Natalizumab.Approved
Lx211The risk or severity of adverse effects can be increased when Lx211 is combined with Natalizumab.Investigational
MechlorethamineThe risk or severity of adverse effects can be increased when Mechlorethamine is combined with Natalizumab.Approved
MelphalanThe risk or severity of adverse effects can be increased when Melphalan is combined with Natalizumab.Approved
MepolizumabThe risk or severity of adverse effects can be increased when Mepolizumab is combined with Natalizumab.Approved, Investigational
MercaptopurineThe risk or severity of adverse effects can be increased when Mercaptopurine is combined with Natalizumab.Approved
MethotrexateThe risk or severity of adverse effects can be increased when Methotrexate is combined with Natalizumab.Approved
MethylprednisoloneThe risk or severity of adverse effects can be increased when Methylprednisolone is combined with Natalizumab.Approved, Vet Approved
MitomycinThe risk or severity of adverse effects can be increased when Mitomycin is combined with Natalizumab.Approved
MitoxantroneThe risk or severity of adverse effects can be increased when Mitoxantrone is combined with Natalizumab.Approved, Investigational
MizoribineThe risk or severity of adverse effects can be increased when Mizoribine is combined with Natalizumab.Investigational
MuromonabThe risk or severity of adverse effects can be increased when Muromonab is combined with Natalizumab.Approved, Investigational
Mycophenolate mofetilThe risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Natalizumab.Approved, Investigational
Mycophenolic acidThe risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Natalizumab.Approved
NafamostatThe risk or severity of adverse effects can be increased when Nafamostat is combined with Natalizumab.Investigational
NelarabineThe risk or severity of adverse effects can be increased when Nelarabine is combined with Natalizumab.Approved, Investigational
NilotinibThe risk or severity of adverse effects can be increased when Nilotinib is combined with Natalizumab.Approved, Investigational
ObinutuzumabThe risk or severity of adverse effects can be increased when Obinutuzumab is combined with Natalizumab.Approved
OxaliplatinThe risk or severity of adverse effects can be increased when Oxaliplatin is combined with Natalizumab.Approved, Investigational
PaclitaxelThe risk or severity of adverse effects can be increased when Paclitaxel is combined with Natalizumab.Approved, Vet Approved
PalbociclibThe risk or severity of adverse effects can be increased when Palbociclib is combined with Natalizumab.Approved
PanobinostatThe risk or severity of adverse effects can be increased when Panobinostat is combined with Natalizumab.Approved, Investigational
PazopanibThe risk or severity of adverse effects can be increased when Pazopanib is combined with Natalizumab.Approved
PegaspargaseThe risk or severity of adverse effects can be increased when Pegaspargase is combined with Natalizumab.Approved, Investigational
PemetrexedThe risk or severity of adverse effects can be increased when Pemetrexed is combined with Natalizumab.Approved, Investigational
PentostatinThe risk or severity of adverse effects can be increased when Pentostatin is combined with Natalizumab.Approved, Investigational
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Natalizumab.Approved, Investigational
PirarubicinThe risk or severity of adverse effects can be increased when Pirarubicin is combined with Natalizumab.Investigational
PirfenidoneThe risk or severity of adverse effects can be increased when Pirfenidone is combined with Natalizumab.Investigational
PomalidomideThe risk or severity of adverse effects can be increased when Pomalidomide is combined with Natalizumab.Approved
PralatrexateThe risk or severity of adverse effects can be increased when Pralatrexate is combined with Natalizumab.Approved
PrednisoloneThe risk or severity of adverse effects can be increased when Prednisolone is combined with Natalizumab.Approved, Vet Approved
PrednisoneThe risk or severity of adverse effects can be increased when Prednisone is combined with Natalizumab.Approved, Vet Approved
ProcarbazineThe risk or severity of adverse effects can be increased when Procarbazine is combined with Natalizumab.Approved
Rabies vaccineThe risk or severity of adverse effects can be increased when Natalizumab is combined with Rabies vaccine.Approved
Rabies vaccineThe therapeutic efficacy of Rabies vaccine can be decreased when used in combination with Natalizumab.Approved
RilonaceptThe risk or severity of adverse effects can be increased when Rilonacept is combined with Natalizumab.Approved
RituximabThe risk or severity of adverse effects can be increased when Rituximab is combined with Natalizumab.Approved
RoflumilastRoflumilast may increase the immunosuppressive activities of Natalizumab.Approved
RuxolitinibThe risk or severity of adverse effects can be increased when Ruxolitinib is combined with Natalizumab.Approved
SecukinumabThe risk or severity of adverse effects can be increased when Secukinumab is combined with Natalizumab.Approved
SeocalcitolThe risk or severity of adverse effects can be increased when Seocalcitol is combined with Natalizumab.Experimental
SiltuximabThe risk or severity of adverse effects can be increased when Siltuximab is combined with Natalizumab.Approved
Sipuleucel-TThe therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Natalizumab.Approved
SirolimusThe risk or severity of adverse effects can be increased when Sirolimus is combined with Natalizumab.Approved, Investigational
SorafenibThe risk or severity of adverse effects can be increased when Sorafenib is combined with Natalizumab.Approved, Investigational
SRP 299The risk or severity of adverse effects can be increased when Natalizumab is combined with SRP 299.Investigational
SteproninThe risk or severity of adverse effects can be increased when Stepronin is combined with Natalizumab.Approved
StreptozocinThe risk or severity of adverse effects can be increased when Streptozocin is combined with Natalizumab.Approved
SunitinibThe risk or severity of adverse effects can be increased when Sunitinib is combined with Natalizumab.Approved, Investigational
TacrolimusThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Natalizumab.Approved, Investigational
TemozolomideThe risk or severity of adverse effects can be increased when Temozolomide is combined with Natalizumab.Approved, Investigational
TemsirolimusThe risk or severity of adverse effects can be increased when Temsirolimus is combined with Natalizumab.Approved
TeniposideThe risk or severity of adverse effects can be increased when Teniposide is combined with Natalizumab.Approved
TepoxalinThe risk or severity of adverse effects can be increased when Tepoxalin is combined with Natalizumab.Vet Approved
TeriflunomideThe risk or severity of adverse effects can be increased when Teriflunomide is combined with Natalizumab.Approved
TG4010The risk or severity of adverse effects can be increased when Natalizumab is combined with TG4010.Investigational
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Natalizumab.Approved, Investigational, Withdrawn
ThiotepaThe risk or severity of adverse effects can be increased when Thiotepa is combined with Natalizumab.Approved
TioguanineThe risk or severity of adverse effects can be increased when Tioguanine is combined with Natalizumab.Approved
TocilizumabThe risk or severity of adverse effects can be increased when Tocilizumab is combined with Natalizumab.Approved
TofacitinibThe risk or severity of adverse effects can be increased when Tofacitinib is combined with Natalizumab.Approved, Investigational
TopotecanThe risk or severity of adverse effects can be increased when Topotecan is combined with Natalizumab.Approved, Investigational
TositumomabThe risk or severity of adverse effects can be increased when Tositumomab is combined with Natalizumab.Approved
TrabectedinThe risk or severity of adverse effects can be increased when Trabectedin is combined with Natalizumab.Approved, Investigational
TrastuzumabTrastuzumab may increase the neutropenic activities of Natalizumab.Approved, Investigational
Trastuzumab emtansineThe risk or severity of adverse effects can be increased when Trastuzumab emtansine is combined with Natalizumab.Approved
TretinoinThe risk or severity of adverse effects can be increased when Tretinoin is combined with Natalizumab.Approved, Investigational, Nutraceutical
TriamcinoloneThe risk or severity of adverse effects can be increased when Triamcinolone is combined with Natalizumab.Approved, Vet Approved
TrofosfamideThe risk or severity of adverse effects can be increased when Trofosfamide is combined with Natalizumab.Investigational
UstekinumabThe risk or severity of adverse effects can be increased when Ustekinumab is combined with Natalizumab.Approved, Investigational
VedolizumabThe risk or severity of adverse effects can be increased when Vedolizumab is combined with Natalizumab.Approved
VilanterolThe risk or severity of adverse effects can be increased when Vilanterol is combined with Natalizumab.Approved
VinblastineThe risk or severity of adverse effects can be increased when Vinblastine is combined with Natalizumab.Approved
VincristineThe risk or severity of adverse effects can be increased when Vincristine is combined with Natalizumab.Approved, Investigational
VindesineThe risk or severity of adverse effects can be increased when Vindesine is combined with Natalizumab.Approved
VinorelbineThe risk or severity of adverse effects can be increased when Vinorelbine is combined with Natalizumab.Approved, Investigational
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General References
  1. Ghosh S, Goldin E, Gordon FH, Malchow HA, Rask-Madsen J, Rutgeerts P, Vyhnalek P, Zadorova Z, Palmer T, Donoghue S: Natalizumab for active Crohn's disease. N Engl J Med. 2003 Jan 2;348(1):24-32. [PubMed:12510039 ]
External Links
ATC CodesL04AA23
AHFS Codes
  • 92:00.00
PDB Entries
FDA labelDownload (96 KB)
MSDSNot Available
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
InjectionIntravenous300 mg/15mL
SolutionIntravenous300 mg
Prices
Unit descriptionCostUnit
Tysabri 300 mg/15 ml vial207.31USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateLiquid
Experimental Properties
PropertyValueSource
melting point61 °C (FAB fragment), 71 °C (whole mAb)Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000)
Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antibody
General Function:
Metal ion binding
Specific Function:
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On act...
Gene Name:
ITGA4
Uniprot ID:
P13612
Molecular Weight:
114898.745 Da
References
  1. Sheremata WA, Minagar A, Alexander JS, Vollmer T: The role of alpha-4 integrin in the aetiology of multiple sclerosis: current knowledge and therapeutic implications. CNS Drugs. 2005;19(11):909-22. [PubMed:16268663 ]
  2. Niino M, Bodner C, Simard ML, Alatab S, Gano D, Kim HJ, Trigueiro M, Racicot D, Guerette C, Antel JP, Fournier A, Grand'Maison F, Bar-Or A: Natalizumab effects on immune cell responses in multiple sclerosis. Ann Neurol. 2006 May;59(5):748-54. [PubMed:16634035 ]
  3. Stuve O, Bennett JL: Pharmacological properties, toxicology and scientific rationale for the use of natalizumab (Tysabri) in inflammatory diseases. CNS Drug Rev. 2007 Spring;13(1):79-95. [PubMed:17461891 ]
  4. Craddock CF, Nakamoto B, Andrews RG, Priestley GV, Papayannopoulou T: Antibodies to VLA4 integrin mobilize long-term repopulating cells and augment cytokine-induced mobilization in primates and mice. Blood. 1997 Dec 15;90(12):4779-88. [PubMed:9389694 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Gene Name:
FCGR3B
Uniprot ID:
O75015
Molecular Weight:
26215.64 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Serine-type peptidase activity
Specific Function:
C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
Gene Name:
C1R
Uniprot ID:
P00736
Molecular Weight:
80118.04 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Gene Name:
C1QA
Uniprot ID:
P02745
Molecular Weight:
26016.47 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Gene Name:
C1QB
Uniprot ID:
P02746
Molecular Weight:
26721.62 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Gene Name:
C1QC
Uniprot ID:
P02747
Molecular Weight:
25773.56 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
Gene Name:
FCGR3A
Uniprot ID:
P08637
Molecular Weight:
29088.895 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Receptor signaling protein activity
Specific Function:
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
Gene Name:
FCGR1A
Uniprot ID:
P12314
Molecular Weight:
42631.525 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
Gene Name:
FCGR2A
Uniprot ID:
P12318
Molecular Weight:
35000.42 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells ...
Gene Name:
FCGR2B
Uniprot ID:
P31994
Molecular Weight:
34043.355 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Transmembrane signaling receptor activity
Specific Function:
Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.
Gene Name:
FCGR2C
Uniprot ID:
P31995
Molecular Weight:
35577.96 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Virus receptor activity
Specific Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243). Acts as a receptor...
Gene Name:
ICAM1
Uniprot ID:
P05362
Molecular Weight:
57824.785 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23