Identification
NameMetformin
Accession NumberDB00331  (APRD01099)
TypeSmall Molecule
GroupsApproved
Description

Metformin is a biguanide antihyperglycemic agent used for treating non-insulin-dependent diabetes mellitus (NIDDM). It improves glycemic control by decreasing hepatic glucose production, decreasing glucose absorption and increasing insulin-mediated glucose uptake. Metformin may induce weight loss and is the drug of choice for obese NIDDM patients. Use of metformin is associated with modest weight loss. When used alone, metformin does not cause hypoglycemia; however, it may potentiate the hypoglycemic effects of sulfonylureas and insulin. Its main side effects are dyspepsia, nausea and diarrhea. Dose titration and/or use of smaller divided doses may decrease side effects. Metformin should be avoided in those with severely compromised renal function (creatinine clearance < 30 ml/min), acute/decompensated heart failure, severe liver disease and for 48 hours after the use of iodinated contrast dyes due to the risk of lactic acidosis. Lower doses should be used in the elderly and those with decreased renal function. Metformin decreases fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Metformin may also have a positive effect on lipid levels. In 2012, a combination tablet of linagliptin plus metformin hydrochloride was marketed under the name Jentadueto for use in patients when treatment with both linagliptin and metformin is appropriate.

Structure
Thumb
Synonyms
1,1-Dimethylbiguanide
Dimethylbiguanid
Haurymellin
Metformin
Metformina
Metformine
Metformine pamoate
Metforminum
N,N-Dimethylimidodicarbonimidic diamide
External IDs LA 6023
Product Ingredients
IngredientUNIICASInChI KeyDetails
Metformin Hydrochloride786Z46389E 1115-70-4OETHQSJEHLVLGH-UHFFFAOYSA-NDetails
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act MetforminTablet500 mgOralActavis Pharma Company2004-11-05Not applicableCanada
Act MetforminTablet850 mgOralActavis Pharma Company2004-11-05Not applicableCanada
Auro-metforminTablet500 mgOralAuro Pharma Inc2015-04-08Not applicableCanada
Auro-metforminTablet850 mgOralAuro Pharma Inc2015-04-08Not applicableCanada
Ava-metforminTablet500 mgOralAvanstra Inc2011-09-152014-08-21Canada
Ava-metforminTablet850 mgOralAvanstra Inc2011-09-152014-08-21Canada
Bci MetforminTablet500 mgOralBaker Cummins Inc2005-04-072006-10-03Canada
Bci MetforminTablet850 mgOralBaker Cummins Inc2005-07-042006-10-03Canada
Bio-metforminTablet500 mgOralBiomed PharmaNot applicableNot applicableCanada
Bio-metforminTablet850 mgOralBiomed PharmaNot applicableNot applicableCanada
Dom-metforminTablet500 mgOralDominion Pharmacal1999-12-16Not applicableCanada
Dom-metforminTablet850 mgOralDominion Pharmacal2000-10-26Not applicableCanada
Ecl-metforminTablet500 mgOralEcl Pharma Group Ltd2014-07-04Not applicableCanada
Ecl-metforminTablet850 mgOralEcl Pharma Group Ltd2014-07-04Not applicableCanada
FortametTablet, extended release500 mg/1OralPhysicians Total Care, Inc.2006-03-24Not applicableUs
FortametTablet, film coated, extended release500 mg/1OralShionogi2004-04-27Not applicableUs
FortametTablet, film coated, extended release1000 mg/1OralShionogi2004-04-27Not applicableUs
FortametTablet, extended release1000 mg/1OralPhysicians Total Care, Inc.2010-02-18Not applicableUs
GlucophageTablet, film coated500 mg/1OralBristol Myers Squibb2009-06-01Not applicableUs
GlucophageTablet, film coated850 mg/1OralBristol Myers Squibb2009-06-01Not applicableUs
GlucophageTablet, film coated1000 mg/1OralBristol Myers Squibb2009-06-01Not applicableUs
GlucophageTablet1000 mgOralSanofi AventisNot applicableNot applicableCanada
GlucophageTablet, film coated500 mg/1OralPd Rx Pharmaceuticals, Inc.2009-06-01Not applicableUs
GlucophageTablet500 mgOralSanofi Aventis1995-12-31Not applicableCanada
GlucophageTablet850 mgOralSanofi Aventis1995-12-31Not applicableCanada
Glucophage XRTablet, extended release500 mg/1OralBristol Myers Squibb2009-06-01Not applicableUs
Glucophage XRTablet, extended release750 mg/1OralBristol Myers Squibb2009-06-01Not applicableUs
GlumetzaTablet, film coated, extended release500 mg/1OralSantarus, Inc..2006-08-01Not applicableUs
GlumetzaTablet, extended release500 mgOralValeant Canada Lp Valeant Canada S.E.C.2005-11-03Not applicableCanada
GlumetzaTablet, film coated, extended release1000 mg/1OralSantarus, Inc..2008-06-17Not applicableUs
GlumetzaTablet, extended release1000 mgOralValeant Canada Lp Valeant Canada S.E.C.2008-01-08Not applicableCanada
GlumetzaTablet, film coated, extended release500 mg/1OralDepomed2006-08-01Not applicableUs
GlumetzaTablet, film coated, extended release1000 mg/1OralDepomed2008-06-17Not applicableUs
Glumetza (sb)Tablet, extended release1000 mgOralValeant Canada Lp Valeant Canada S.E.C.Not applicableNot applicableCanada
GlyconTablet500 mgOralValeant Canada Lp Valeant Canada S.E.C.1996-11-12Not applicableCanada
Glycon 850mgTablet850 mgOralValeant Canada Lp Valeant Canada S.E.C.1999-02-18Not applicableCanada
Ipg-metforminTablet500 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-metforminTablet850 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Jamp-metforminTablet500 mgOralJamp Pharma Corporation2012-03-22Not applicableCanada
Jamp-metforminTablet850 mgOralJamp Pharma Corporation2012-03-22Not applicableCanada
Jamp-metformin BlackberryTablet500 mgOralJamp Pharma Corporation2012-03-19Not applicableCanada
Jamp-metformin BlackberryTablet850 mgOralJamp Pharma Corporation2012-03-19Not applicableCanada
Mar-metforminTablet500 mgOralMarcan Pharmaceuticals Inc2013-01-08Not applicableCanada
Mar-metforminTablet850 mgOralMarcan Pharmaceuticals Inc2013-01-08Not applicableCanada
Med Metformin Tablets 500mgTablet500 mgOralMedican Pharma Incorporated1997-02-282011-03-29Canada
MetforminTablet500 mgOralSanis Health Inc2010-07-26Not applicableCanada
MetforminTablet850 mgOralSorres Pharma Inc2000-10-262014-06-20Canada
MetforminTablet850 mgOralMeliapharm Inc2003-01-072014-06-25Canada
MetforminTablet850 mgOralSanis Health Inc2010-07-26Not applicableCanada
MetforminTablet500 mgOralCobalt LaboratoriesNot applicableNot applicableCanada
MetforminTablet500 mgOralMeliapharm Inc2000-10-262014-06-25Canada
MetforminTablet850 mgOralCobalt LaboratoriesNot applicableNot applicableCanada
MetforminTablet500 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
MetforminTablet500 mgOralMylan Pharmaceuticals2009-10-222012-10-19Canada
MetforminTablet850 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
MetforminTablet500 mgOralBdh Inc.1997-08-192000-08-03Canada
MetforminTablet500 mgOralLaboratoires Confab IncNot applicableNot applicableCanada
MetforminTablet850 mgOralMylan Pharmaceuticals2009-10-222012-10-19Canada
Metformin FcTablet500 mgOralSivem Pharmaceuticals Ulc2012-06-10Not applicableCanada
Metformin FcTablet850 mgOralSivem Pharmaceuticals Ulc2012-06-10Not applicableCanada
Metformin HydrochlorideTablet, film coated, extended release500 mg/1OralOceanside Pharmaceuticals2006-08-01Not applicableUs
Metformin HydrochlorideTablet, film coated, extended release1000 mg/1OralOceanside Pharmaceuticals2006-08-01Not applicableUs
Metformin HydrochlorideTablet, film coated, extended release1000 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2012-04-18Not applicableUs
Metformin HydrochlorideTablet, film coated, extended release500 mg/1OralActavis Pharma Company2012-04-18Not applicableUs
Metformin HydrochlorideTablet, film coated, extended release1000 mg/1OralActavis Pharma Company2012-04-18Not applicableUs
Metformin TabletsTablet850 mgOralAccord Healthcare LimitedNot applicableNot applicableCanada
Metformin TabletsTablet500 mgOralAccord Healthcare LimitedNot applicableNot applicableCanada
Metformin Tablets 500mgTablet500 mgOralPrempharm Inc1996-12-302005-08-05Canada
Metformin-500 - Tab 500mgTablet500 mgOralPro Doc Limitee1996-12-062010-07-13Canada
Metformin-850Tablet850 mgOralPro Doc Limitee1997-08-062010-07-13Canada
Mint-metforminTablet500 mgOralMint Pharmaceuticals Inc2012-07-25Not applicableCanada
Mint-metforminTablet850 mgOralMint Pharmaceuticals Inc2012-07-25Not applicableCanada
Mylan-metforminTablet850 mgOralMylan Pharmaceuticals1997-05-12Not applicableCanada
Mylan-metforminTablet500 mgOralMylan Pharmaceuticals1995-12-31Not applicableCanada
Ntp-metforminTablet850 mgOralNt Pharma Canada LtdNot applicableNot applicableCanada
Ntp-metforminTablet500 mgOralNt Pharma Canada LtdNot applicableNot applicableCanada
Nu-metformin - Tab 500mgTablet500 mgOralNu Pharm Inc1995-12-312012-09-04Canada
Nu-metformin (850mg)Tablet850 mgOralNu Pharm Inc1997-06-102012-09-04Canada
Orb-metforminTablet500 mgOralOrbus Pharma IncNot applicableNot applicableCanada
Orb-metforminTablet850 mgOralOrbus Pharma IncNot applicableNot applicableCanada
Pg-metforminTablet500 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Pg-metforminTablet850 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
PHL-metforminTablet500 mgOralPharmel Inc2003-01-07Not applicableCanada
PMS-metforminTablet850 mgOralPharmascience Inc2000-07-28Not applicableCanada
PMS-metformin - Tab 500mgTablet500 mgOralPharmascience Inc1996-09-05Not applicableCanada
Priva-metforminTablet500 mgOralPharmapar IncNot applicableNot applicableCanada
Priva-metforminTablet850 mgOralPharmapar IncNot applicableNot applicableCanada
Pro-metforminTablet850 mgOralPro Doc Limitee2008-10-27Not applicableCanada
Pro-metforminTablet500 mgOralPro Doc Limitee2008-10-27Not applicableCanada
Q-metforminTablet500 mgOralQd Pharmaceuticals Ulc2011-11-082015-08-21Canada
Q-metforminTablet850 mgOralQd Pharmaceuticals Ulc2011-11-082015-08-21Canada
Ran-metforminTablet500 mgOralRanbaxy Inc.2005-07-12Not applicableCanada
Ran-metforminTablet850 mgOralRanbaxy Inc.2005-07-12Not applicableCanada
Ratio-metforminTablet500 mgOralTeva2001-01-04Not applicableCanada
Ratio-metforminTablet850 mgOralTeva2001-01-04Not applicableCanada
Rhoxal-metforminTablet500 mgOralRhoxalpharma Inc1997-12-022009-11-24Canada
RiometSolution500 mg/5mLOralRanbaxy Inc.2004-01-04Not applicableUs
RiometSolution500 mg/5mLOralRanbaxy Inc.2004-01-04Not applicableUs
Riva-metforminTablet850 mgOralLaboratoire Riva Inc2001-10-18Not applicableCanada
Riva-metforminTablet500 mgOralLaboratoire Riva Inc1999-05-31Not applicableCanada
Sandoz Metformin FcTablet500 mgOralSandoz Canada Incorporated2002-12-20Not applicableCanada
Sandoz Metformin FcTablet850 mgOralSandoz Canada Incorporated2002-12-20Not applicableCanada
Septa-metforminTablet500 mgOralSepta Pharmaceuticals Inc2012-11-21Not applicableCanada
Septa-metforminTablet850 mgOralSepta Pharmaceuticals Inc2012-11-21Not applicableCanada
Teva-metforminTablet850 mgOralTeva1997-05-05Not applicableCanada
Teva-metforminTablet500 mgOralTeva1993-12-31Not applicableCanada
Van-metforminTablet500 mgOralVanc Pharmaceuticals IncNot applicableNot applicableCanada
Van-metforminTablet850 mgOralVanc Pharmaceuticals IncNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-metformin - Tab 500mgTablet500 mgOralApotex Corporation1995-12-31Not applicableCanada
Apo-metformin 850 Mg TabletsTablet850 mgOralApotex Corporation1996-11-20Not applicableCanada
Apo-metformin ERTablet, extended release1000 mgOralApotex CorporationNot applicableNot applicableCanada
Apo-metformin ERTablet, extended release500 mgOralApotex CorporationNot applicableNot applicableCanada
Dm2KitHudson Scientific Llc2017-01-20Not applicableUs
Metfomin HydrochlorideTablet850 mg/1OralRemedy Repack2011-08-102016-11-04Us
Metformin HClTablet500 mg/1OralAscend Laboratories, LLC2017-02-06Not applicableUs
Metformin HClTablet, film coated1000 mg/1OralTime Cap Laboratories2016-11-14Not applicableUs
Metformin HClTablet500 mg/1OralCambridge Therapeutics Technologies, Llc2017-02-06Not applicableUs
Metformin HClTablet, film coated850 mg/1OralTime Cap Laboratories2016-11-14Not applicableUs
Metformin HClTablet850 mg/1OralAscend Laboratories, LLC2017-02-06Not applicableUs
Metformin HClTablet, film coated500 mg/1OralTime Cap Laboratories2016-11-14Not applicableUs
Metformin HClTablet1000 mg/1OralAscend Laboratories, LLC2017-02-06Not applicableUs
Metformin HCl ERTablet500 mg/1OralNorthwind Pharmaceuticals2015-05-22Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralCarilion Materials Management2009-12-02Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralApotex Corporation2011-12-07Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralLegacy Pharmaceutical Packaging2012-01-13Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralBlenheim Pharmacal, Inc.2013-12-17Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralPd Rx Pharmaceuticals, Inc.2003-04-17Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralSolco healthcare U.S., LLC2013-04-15Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2006-02-09Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralAmerincan Health Packaging2015-06-01Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralCardinal Health2009-06-032015-12-29Us
Metformin HydrochlorideTablet1000 mg/1OralBlenheim Pharmacal, Inc.2010-04-22Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralTeva2002-02-11Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralSafecor Health, LLC2014-09-30Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralAv Kare, Inc.2012-06-26Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralRemedy Repack2013-03-142016-12-21Us
Metformin HydrochlorideTablet, film coated1000 mg/1OralMylan Institutional2012-10-05Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralRemedy Repack2015-01-232017-03-11Us
Metformin HydrochlorideTablet, film coated1000 mg/1OralRemedy Repack2013-05-142017-01-18Us
Metformin HydrochlorideTablet, film coated1000 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2005-01-14Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralAphena Pharma Solutions Tennessee, Inc.2014-12-09Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralCardinal Health2010-01-11Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralCadila Pharnmaceuticals2014-12-09Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2010-04-22Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralAv Kare, Inc.2009-12-02Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralCardinal Health2009-09-15Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralContract Pharmacy Services Pa2010-04-09Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralNucare Pharmaceuticals, Inc.2010-04-22Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralPd Rx Pharmaceuticals, Inc.2012-04-27Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralA S Medication Solutions2005-01-14Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralSandoz2002-01-25Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralWatson Pharma, Inc.2002-01-252016-10-13Us
Metformin HydrochlorideTablet, film coated1000 mg/1OralGreenstone, Llc2005-01-142015-11-30Us
Metformin HydrochlorideTablet, extended release500 mg/1OralRemedy Repack2017-05-09Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralRemedy Repack2011-08-102016-11-04Us
Metformin HydrochlorideTablet500 mg/1OralMajor2010-01-11Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralProficient Rx LP2014-02-01Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralLupin Pharmaceuticals2016-02-01Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1Oralbryant ranch prepack2005-01-14Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralSciegen Pharmaceuticals Inc.2015-02-01Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralActavis Pharma Company2005-04-12Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralAmneal Pharmaceuticals of New York Llc2010-02-26Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralAurobindo Pharma2005-01-14Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralRebel Distributors2002-01-29Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralAscend Laboratories, LLC2011-01-31Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralHeritage2010-04-22Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralA S Medication Solutions2002-01-29Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralClinical Solutions Wholsesale2002-01-25Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralZydus Pharmaceuticals Usa, Inc.2005-09-28Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralMajor2014-02-03Not applicableUs
Metformin HydrochlorideTablet, extended release1000 mg/1OralLupin Pharmaceuticals2011-09-30Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralAphena Pharma Solutions Tennessee, Inc.2002-01-25Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralCardinal Health2015-06-01Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralGolden State Medical Supply2013-09-11Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralZydus Pharmaceuticals Usa, Inc.2014-12-09Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralBlenheim Pharmacal, Inc.2013-08-30Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralAvera Mc Kennan Hospital2016-10-17Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralAphena Pharma Solutions Tennessee, Inc.2014-02-03Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2005-09-28Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralClinical Solutions Wholsesale2005-01-14Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralMylan Institutional2012-07-022017-01-18Us
Metformin HydrochlorideTablet850 mg/1OralPreferreed Pharmaceuticals Inc.2002-01-29Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralAmneal Pharmaceuticals2009-06-01Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralCarlsbad Technology, Inc.2014-02-01Not applicableUs
Metformin HydrochlorideTablet, film coated, extended release1000 mg/1OralMylan Pharmaceuticals2016-08-23Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralState of Florida DOH Central Pharmacy2012-01-01Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralEon Labs, Inc.2002-01-25Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralMylan Pharmaceuticals2010-06-03Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralBlu Pharmceuticals Llc2013-09-032017-05-09Us
Metformin HydrochlorideTablet, film coated500 mg/1OralEpic Pharma, LLC2016-04-01Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralPhysicians Total Care, Inc.2002-03-12Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-27Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralIngenus Pharmaceuticals Llc2014-07-16Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralAidarex Pharmaceuticals LLC2002-01-29Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralAvera Mc Kennan Hospital2015-05-27Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralApotex Corporation2011-12-07Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralAvera Mc Kennan Hospital2015-06-29Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralBlenheim Pharmacal, Inc.2013-10-03Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralPd Rx Pharmaceuticals, Inc.2002-01-29Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralSolco healthcare U.S., LLC2013-04-15Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralDirectrx2014-01-01Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralSt. Marys Medical Park Pharmacy2006-02-09Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralCardinal Health2009-06-032015-12-29Us
Metformin HydrochlorideTablet, film coated500 mg/1OralTorrent Pharmaceuticals Limited2007-01-24Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralTeva2003-04-17Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralInventia Healthcare Private Limited2012-06-01Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralHudson Scientific Llc2004-06-16Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralAv Kare, Inc.2012-06-26Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralRemedy Repack2013-03-292016-12-24Us
Metformin HydrochlorideTablet, extended release500 mg/1OralAv Kare, Inc.2017-01-13Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralRemedy Repack2015-04-142017-04-14Us
Metformin HydrochlorideTablet, extended release500 mg/1OralRemedy Repack2013-05-232017-01-06Us
Metformin HydrochlorideTablet, film coated1000 mg/1OralAphena Pharma Solutions Tennessee, Inc.2005-01-14Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralCardinal Health2009-11-18Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralCadila Pharnmaceuticals2014-12-09Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralRemedy Repack2017-02-17Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralAv Kare, Inc.2009-12-02Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralA S Medication Solutions2010-04-22Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralCardinal Health2011-01-31Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralContract Pharmacy Services Pa2010-07-29Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralNucare Pharmaceuticals, Inc.2010-04-22Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralPd Rx Pharmaceuticals, Inc.2005-09-28Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralA S Medication Solutions2006-02-09Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralSandoz2002-01-25Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralWatson Pharma, Inc.2002-01-252016-10-13Us
Metformin HydrochlorideTablet, film coated1000 mg/1OralBlenheim Pharmacal, Inc.2016-01-07Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralRed Pharm Drug, Inc.2005-01-14Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralMajor2010-01-11Not applicableUs
Metformin HydrochlorideTablet500 mg/1Oralbryant ranch prepack2010-04-22Not applicableUs
Metformin HydrochlorideTablet, extended release1000 mg/1OralLupin Pharmaceuticals2016-02-01Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1Oralbryant ranch prepack2005-01-14Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralSciegen Pharmaceuticals Inc.2015-02-01Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2005-01-14Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralTorrent Pharmaceuticals Limited2007-01-24Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralAmerincan Health Packaging2007-12-212016-11-30Us
Metformin HydrochlorideTablet500 mg/1OralAmneal Pharmaceuticals of New York Llc2012-12-17Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralLegacy Pharmaceutical Packaging2014-12-09Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralRebel Distributors2002-01-29Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralAscend Laboratories, LLC2011-01-31Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralA S Medication Solutions2009-12-02Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralClinical Solutions Wholsesale2009-12-02Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralZydus Pharmaceuticals Usa, Inc.2005-09-28Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralMajor2014-02-03Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralMethod Pharmaceuticals2017-03-15Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralAphena Pharma Solutions Tennessee, Inc.2002-01-25Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2002-01-29Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralGolden State Medical Supply2013-09-11Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralZydus Pharmaceuticals Usa, Inc.2014-12-09Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralBlenheim Pharmacal, Inc.2013-09-30Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralRemedy Repack2017-03-23Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralAphena Pharma Solutions Tennessee, Inc.2014-02-03Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralReady Meds2012-12-17Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralLiberty Pharmaceuticals, Inc.2016-03-31Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralMed Pharma Co., Ltd.2011-01-04Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralPreferreed Pharmaceuticals Inc.2002-01-29Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralAmneal Pharmaceuticals2009-06-01Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralCarlsbad Technology, Inc.2014-02-01Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralNorthwind Pharmaceuticals2014-04-08Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralKaiser Foundations Hospitals2015-07-07Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralRemedy Repack2011-11-142017-01-14Us
Metformin HydrochlorideTablet, film coated, extended release500 mg/1OralMylan Pharmaceuticals2016-08-23Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralEon Labs, Inc.2004-12-14Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralMylan Pharmaceuticals2010-06-03Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralMARKSANS PHARMA LIMITED2012-06-01Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralEpic Pharma, LLC2016-04-01Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralPhysicians Total Care, Inc.2002-01-30Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralUnit Dose Services2010-04-22Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralApotex Corporation2004-12-16Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralBlenheim Pharmacal, Inc.2010-04-22Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralNucare Pharmaceuticals, Inc.2013-03-01Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralSolco healthcare U.S., LLC2013-04-15Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralA S Medication Solutions2006-02-09Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralSt. Marys Medical Park Pharmacy2013-05-15Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralCardinal Health2002-01-252015-12-29Us
Metformin HydrochlorideTablet, film coated850 mg/1OralTorrent Pharmaceuticals Limited2007-01-24Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralPd Rx Pharmaceuticals, Inc.2012-12-17Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralRemedy Repack2010-10-202016-10-26Us
Metformin HydrochlorideTablet, film coated1000 mg/1OralLegacy Pharmaceutical Packaging2014-07-16Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralAv Kare, Inc.2012-06-26Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralRemedy Repack2013-02-09Not applicableUs
Metformin HydrochlorideTablet, extended release1000 mg/1OralAv Kare, Inc.2017-01-13Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralRemedy Repack2015-04-24Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralRemedy Repack2013-05-292017-03-03Us
Metformin HydrochlorideTablet, film coated500 mg/1OralCadila Pharnmaceuticals2005-09-28Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralIngenus Pharmaceuticals Llc2014-07-16Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralAidarex Pharmaceuticals LLC2002-01-29Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralAphena Pharma Solutions Tennessee, Inc.2011-01-31Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralCardinal Health2011-01-31Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralCadila Pharnmaceuticals2014-12-09Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralNucare Pharmaceuticals, Inc.2006-02-09Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralPd Rx Pharmaceuticals, Inc.2012-04-27Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralA S Medication Solutions2012-12-17Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralCardinal Health2012-12-14Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-27Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralPreferreed Pharmaceuticals Inc.2016-10-25Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralSun Pharmaceutical Industries Limited2006-02-09Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralTeva2005-04-13Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralRemedy Repack2013-03-012016-11-15Us
Metformin HydrochlorideTablet, film coated1000 mg/1OralRed Pharm Drug, Inc.2005-01-14Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1Oralbryant ranch prepack2009-06-03Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralDirectrx2016-02-05Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1Oralbryant ranch prepack2002-02-11Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralSciegen Pharmaceuticals Inc.2015-02-01Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralHudson Scientific Llc2016-12-26Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralTorrent Pharmaceuticals Limited2009-12-30Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralAmerincan Health Packaging2008-02-252016-10-31Us
Metformin HydrochlorideTablet850 mg/1OralAmneal Pharmaceuticals of New York Llc2012-12-17Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralLegacy Pharmaceutical Packaging2010-04-22Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralRebel Distributors2002-01-29Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralAscend Laboratories, LLC2011-01-31Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralContract Pharmacy Services Pa2010-07-29Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralMajor2010-01-11Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralEpic Pharma, LLC2017-03-13Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralPd Rx Pharmaceuticals, Inc.2014-02-01Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralA S Medication Solutions2010-02-26Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralClinical Solutions Wholsesale2009-06-03Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralZydus Pharmaceuticals Usa, Inc.2005-09-28Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralMajor2014-02-03Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralMethod Pharmaceuticals2017-03-15Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralAphena Pharma Solutions Tennessee, Inc.2002-01-25Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralCitron Pharma LLC2012-07-20Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralReady Meds2012-12-17Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralLiberty Pharmaceuticals, Inc.2016-03-31Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralMed Pharma Co., Ltd.2011-01-04Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralLegacy Pharmaceutical Packaging2014-12-09Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralAmneal Pharmaceuticals of New York Llc2012-12-17Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralClinical Solutions Wholsesale2016-04-05Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralNorthwind Pharmaceuticals2014-04-30Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralKaiser Foundations Hospitals2015-07-07Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralRemedy Repack2013-04-082017-01-14Us
Metformin HydrochlorideTablet, film coated1000 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2005-01-14Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-06-11Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralMylan Pharmaceuticals2010-06-03Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralMARKSANS PHARMA LIMITED2012-06-01Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralEpic Pharma, LLC2016-04-01Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralPhysicians Total Care, Inc.2002-03-11Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralGlenmark Pharmaceuticals Inc.,Usa2008-05-23Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralBlenheim Pharmacal, Inc.2011-03-21Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralRemedy Repack2017-04-04Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralSolco healthcare U.S., LLC2009-06-03Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralUnit Dose Services2002-01-29Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralApotex Corporation2005-12-29Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralLife Line Home Care Services2002-01-30Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralBlenheim Pharmacal, Inc.2014-01-30Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralAurobindo Pharma2012-07-20Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralSolco healthcare U.S., LLC2014-10-15Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralA S Medication Solutions2005-01-142016-10-26Us
Metformin HydrochlorideTablet850 mg/1OralSt. Marys Medical Park Pharmacy2013-05-15Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralMacleods Pharmaceuticals Limited2016-12-08Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralUnit Dose Services2010-04-22Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralRemedy Repack2013-05-072017-01-20Us
Metformin HydrochlorideTablet, film coated500 mg/1OralApotheca, Inc.2011-01-31Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralRemedy Repack2015-05-112017-04-14Us
Metformin HydrochlorideTablet, extended release500 mg/1OralRemedy Repack2013-09-042016-12-30Us
Metformin HydrochlorideTablet, film coated850 mg/1OralCadila Pharnmaceuticals2005-09-28Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralIngenus Pharmaceuticals Llc2014-07-16Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralAidarex Pharmaceuticals LLC2009-12-02Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralAphena Pharma Solutions Tennessee, Inc.2013-09-11Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralCardinal Health2011-01-31Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralMed Vantx, Inc.2010-07-27Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralPd Rx Pharmaceuticals, Inc.2006-02-09Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralPd Rx Pharmaceuticals, Inc.2005-04-12Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralA S Medication Solutions2010-04-22Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralSun Pharmaceutical Industries Limited2002-01-29Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-27Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralCardinal Health2002-01-252015-12-29Us
Metformin HydrochlorideTablet, extended release500 mg/1OralAmerincan Health Packaging2010-03-19Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralA S Medication Solutions2011-01-31Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralMajor2002-01-25Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralSun Pharmaceutical Industries Limited2006-02-09Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralTeva2004-06-18Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralRemedy Repack2011-09-082016-11-23Us
Metformin HydrochlorideTablet500 mg/1OralRed Pharm Drug, Inc.2002-01-29Not applicableUs
Metformin HydrochlorideTablet1000 mg/1Oralbryant ranch prepack2002-01-29Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralTorrent Pharmaceuticals Limited2010-02-18Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralAmerincan Health Packaging2008-01-302016-10-31Us
Metformin HydrochlorideTablet1000 mg/1OralAmneal Pharmaceuticals of New York Llc2012-12-17Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralRebel Distributors2006-02-09Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralPreferreed Pharmaceuticals Inc.2010-04-22Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralAscend Laboratories, LLC2013-03-01Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralMajor2011-01-31Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralEpic Pharma, LLC2017-03-13Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralPd Rx Pharmaceuticals, Inc.2012-12-17Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralA S Medication Solutions2013-03-01Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralClinical Solutions Wholsesale2005-04-13Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralZydus Pharmaceuticals Usa, Inc.2005-09-28Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralBlenheim Pharmacal, Inc.2003-04-17Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralMethod Pharmaceuticals2017-03-15Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralAphena Pharma Solutions Tennessee, Inc.2012-06-26Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralCitron Pharma LLC2012-07-20Not applicableUs
Metformin HydrochlorideTablet, film coated, extended release500 mg/1OralGolden State Medical Supply2006-08-29Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralAvera Mc Kennan Hospital2015-09-14Not applicableUs
Metformin HydrochlorideTablet, extended release1000 mg/1Oralbryant ranch prepack2011-09-30Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralAv Pak2009-12-02Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralProficient Rx LP2013-03-01Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralTYA Pharmaceuticals2010-04-22Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralLiberty Pharmaceuticals, Inc.2016-03-31Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralMed Pharma Co., Ltd.2011-01-04Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralLegacy Pharmaceutical Packaging2010-04-22Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralAmneal Pharmaceuticals of New York Llc2012-12-17Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralKaiser Foundations Hospitals2015-07-07Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralA S Medication Solutions2011-01-31Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralRemedy Repack2012-07-102016-10-22Us
Metformin HydrochlorideTablet, film coated500 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2005-01-14Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralA S Medication Solutions2012-12-17Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-06-03Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralMARKSANS PHARMA LIMITED2012-06-01Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralAphena Pharma Solutions Tennessee, Inc.2013-09-11Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralPhysicians Total Care, Inc.2006-02-09Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralGlenmark Pharmaceuticals Inc.,Usa2008-05-23Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralBlenheim Pharmacal, Inc.2010-04-22Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralRemedy Repack2017-04-06Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralSolco healthcare U.S., LLC2009-06-03Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralUnit Dose Services2010-04-22Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralAmerincan Health Packaging2015-06-01Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralMc Kesson Contract Packaging2012-01-18Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralBlenheim Pharmacal, Inc.2015-03-27Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralAurobindo Pharma2012-07-20Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralSolco healthcare U.S., LLC2014-10-15Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralA S Medication Solutions2005-12-29Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralSt. Marys Medical Park Pharmacy2013-05-15Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralAv Kare, Inc.2014-12-04Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralMacleods Pharmaceuticals Limited2016-12-08Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralUnit Dose Services2010-04-22Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralRemedy Repack2013-05-092017-03-04Us
Metformin HydrochlorideTablet, film coated850 mg/1OralApotheca, Inc.2011-01-31Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralCadila Pharnmaceuticals2005-09-28Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralA S Medication Solutions2011-01-31Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2010-04-22Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralAphena Pharma Solutions Tennessee, Inc.2013-09-11Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralCardinal Health2011-01-31Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralMed Vantx, Inc.2010-07-27Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralRemedy Repack2016-12-19Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralPd Rx Pharmaceuticals, Inc.2009-12-02Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralA S Medication Solutions2002-01-29Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralSun Pharmaceutical Industries Limited2002-01-29Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-02-09Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralGreenstone, Llc2005-01-142015-11-30Us
Metformin HydrochlorideTablet, film coated, extended release500 mg/1OralActavis Pharma Company2017-05-15Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralRemedy Repack2011-04-292016-03-18Us
Metformin HydrochlorideTablet, film coated500 mg/1OralRemedy Repack2016-11-03Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralMajor2002-01-25Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralProficient Rx LP2005-01-14Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1Oralbryant ranch prepack2006-02-09Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralRemedy Repack2011-12-022016-10-28Us
Metformin HydrochlorideTablet, extended release500 mg/1OralSandoz2016-11-25Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2002-01-29Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralDirectrx2014-01-01Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralShanghai Sine Pharmaceutical Laboratories Co., Ltd.2015-04-27Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralAurobindo Pharma2005-01-14Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralStat Rx USA2005-09-28Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralProficient Rx LP2010-04-22Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2017-01-13Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralHeritage2010-04-22Not applicableUs
Metformin HydrochlorideTablet, extended release1000 mg/1OralAmerincan Health Packaging2014-09-29Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralMajor2011-01-31Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralEpic Pharma, LLC2017-03-13Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralPd Rx Pharmaceuticals, Inc.2014-02-01Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralTAGI Pharma, Inc.2008-04-17Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralNew Horizon Rx Group, LLC2013-08-25Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralZydus Pharmaceuticals Usa, Inc.2005-09-28Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralBlenheim Pharmacal, Inc.2012-02-13Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralNucare Pharmaceuticals, Inc.2010-04-22Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralAphena Pharma Solutions Tennessee, Inc.2012-06-26Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralRemedy Repack2016-05-18Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralApotex Corporation2011-12-07Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralClinical Solutions Wholsesale2005-01-14Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralPd Rx Pharmaceuticals, Inc.2002-01-28Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralAv Pak2014-11-12Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralRemedy Repack2016-12-02Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralTYA Pharmaceuticals2002-01-29Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralUnit Dose Services2010-04-22Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralNorthwind Pharmaceuticals2015-01-09Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralLegacy Pharmaceutical Packaging2010-04-22Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralAmneal Pharmaceuticals of New York Llc2012-12-17Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralPreferreed Pharmaceuticals Inc.2010-04-22Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralEon Labs, Inc.2002-01-25Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralClinical Solutions Wholsesale2010-04-22Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralBlu Pharmceuticals Llc2013-09-032017-05-09Us
Metformin HydrochlorideTablet, extended release500 mg/1OralMARKSANS PHARMA LIMITED2016-05-12Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralA S Medication Solutions2012-12-17Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-06-03Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralA S Medication Solutions2008-04-17Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralNostrum Laboratories, Inc.2012-01-01Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralGlenmark Pharmaceuticals Inc.,Usa2008-05-23Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralBlenheim Pharmacal, Inc.2010-07-20Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralRemedy Repack2017-04-18Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralSolco healthcare U.S., LLC2009-06-03Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralUnit Dose Services2010-04-22Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralAmerincan Health Packaging2015-06-01Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralMc Kesson Contract Packaging2012-01-17Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralBlenheim Pharmacal, Inc.2015-08-27Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralTeva2002-01-28Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralSolco healthcare U.S., LLC2014-10-15Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralA S Medication Solutions2005-01-14Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralWatson Pharma, Inc.2002-01-252016-10-13Us
Metformin HydrochlorideTablet, extended release1000 mg/1OralAv Kare, Inc.2014-12-04Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralNorthwind Pharmaceuticals2015-01-21Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralMylan Institutional2012-08-17Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralClinical Solutions Wholsesale2010-04-22Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralRemedy Repack2013-05-282017-03-03Us
Metformin HydrochlorideTablet, film coated1000 mg/1OralApotheca, Inc.2011-01-31Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralAphena Pharma Solutions Tennessee, Inc.2014-02-01Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralPhysicians Total Care, Inc.2006-02-09Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralCadila Pharnmaceuticals2005-09-28Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2011-01-27Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2002-01-29Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralCardinal Health2010-04-222017-05-04Us
Metformin HydrochlorideTablet, extended release500 mg/1OralMed Vantx, Inc.2010-06-11Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralPd Rx Pharmaceuticals, Inc.2009-06-01Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralSandoz2002-01-25Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralGreenstone, Llc2005-01-142015-11-30Us
Metformin HydrochlorideTablet, film coated, extended release1000 mg/1OralActavis Pharma Company2017-05-15Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralRemedy Repack2011-07-212016-10-13Us
Metformin HydrochlorideTablet500 mg/1OralRemedy Repack2016-11-03Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralMajor2002-01-25Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralProficient Rx LP2005-01-14Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralCarilion Materials Management2010-04-22Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1Oralbryant ranch prepack2005-12-29Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2004-06-16Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralRemedy Repack2011-05-162017-11-28Us
Metformin HydrochlorideTablet850 mg/1OralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2002-01-29Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralActavis Pharma Company2004-06-16Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralAmneal Pharmaceuticals of New York Llc2009-12-02Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralAurobindo Pharma2005-01-14Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralStat Rx USA2005-09-28Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralProficient Rx LP2010-04-22Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralLegacy Pharmaceutical Packaging2014-07-16Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralHeritage2010-04-22Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralA S Medication Solutions2010-04-22Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralSun Pharmaceutical Industries Limited2002-01-29Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralAmerincan Health Packaging2015-03-312017-05-16Us
Metformin HydrochlorideTablet, film coated1000 mg/1OralMajor2011-01-31Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralLupin Pharmaceuticals2011-09-30Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralPd Rx Pharmaceuticals, Inc.2014-02-01Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralTAGI Pharma, Inc.2008-04-17Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralGolden State Medical Supply2013-09-11Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralZydus Pharmaceuticals Usa, Inc.2014-12-09Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralBlenheim Pharmacal, Inc.2012-02-13Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralAphena Pharma Solutions Tennessee, Inc.2012-06-26Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralClinical Solutions Wholsesale2005-01-14Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralUnit Dose Services2004-12-16Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralPreferreed Pharmaceuticals Inc.2002-01-29Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralAmneal Pharmaceuticals2009-06-01Not applicableUs
Metformin HydrochlorideTablet, film coated500 mg/1OralCarlsbad Technology, Inc.2014-02-01Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralNucare Pharmaceuticals, Inc.2002-01-29Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1OralCadila Pharnmaceuticals2005-09-28Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralPreferreed Pharmaceuticals Inc.2010-04-22Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Metformin HydrochlorideTablet850 mg/1OralEon Labs, Inc.2002-01-25Not applicableUs
Metformin HydrochlorideTablet500 mg/1OralA S Medication Solutions2012-12-17Not applicableUs
Metformin HydrochlorideTablet, film coated850 mg/1OralBlu Pharmceuticals Llc2013-09-032017-05-09Us
Metformin HydrochlorideTablet, extended release750 mg/1OralMARKSANS PHARMA LIMITED2016-05-12Not applicableUs
Metformin HydrochlorideTablet1000 mg/1OralA S Medication Solutions2012-12-17Not applicableUs
Metformin HydrochlorideTablet, film coated1000 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-06-03Not applicableUs
Metformin HydrochlorideTablet, extended release500 mg/1Oralbryant ranch prepack2004-12-16Not applicableUs
Metformin HydrochlorideTablet, extended release750 mg/1OralNostrum Laboratories, Inc.2012-01-01Not applicableUs
Metformin Hydrochloride ERTablet, extended release500 mg/1OralNivagen Pharmaceuticals, Inc.2013-11-01Not applicableUs
Metformin Hydrochloride ERTablet, film coated750 mg/1OralGolden State Medical Supply2006-04-12Not applicableUs
Metformin Hydrochloride ERTablet750 mg/1OralNorthwind Pharmaceuticals2014-06-01Not applicableUs
Metformin Hydrochloride ERTablet, extended release500 mg/1OralNorthwind Pharmaceuticals2014-04-23Not applicableUs
Metformin Hydrochloride Extended ReleaseTablet, extended release750 mg/1OralTime Cap Laboratories2016-05-12Not applicableUs
Metformin Hydrochloride Extended ReleaseTablet, extended release500 mg/1OralMajor2009-06-10Not applicableUs
Metformin Hydrochloride Extended ReleaseTablet, extended release750 mg/1OralMajor2009-06-102016-11-11Us
Metformin Hydrochloride Extended ReleaseTablet, extended release500 mg/1OralRemedy Repack2011-04-212016-10-13Us
Metformin Hydrochloride Extended ReleaseTablet, extended release500 mg/1OralDirectrx2015-01-01Not applicableUs
Metformin Hydrochloride Extended ReleaseTablet, extended release500 mg/1OralTime Cap Laboratories2016-05-12Not applicableUs
Metformin Hydrochloride Extended ReleaseTablet, extended release500 mg/1OralNucare Pharmaceuticals, Inc.2016-05-12Not applicableUs
Metformin Hydrochloride Extended ReleaseTablet, extended release500 mg/1OralPreferreed Pharmaceuticals Inc.2017-03-27Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
Apo-MetforminApotex
Gen-MetforminGenpharm ULC
Novo-MetforminNovopharm
Nu-MetforminNu-Pharm
Sandoz MetforminSandox
Brand mixtures
NameLabellerIngredients
Actoplus MetPhysicians Total Care, Inc.
Actoplus Met XRTakeda
Alogliptin and Metformin HydrochloridePerrigo New York Inc.
AppforminPhysician Therapeutics Llc
Appformin-DPhysician Therapeutics Llc
AvandametGlaxosmithkline Inc
Glipizide and Metformin HClLake Erie Medical Dba Quality Care Produts Llc
Glipizide and Metformin HydrochlorideWatson Pharmaceuticals
GlucovanceBristol Myers Squibb
Glyburide (micronized) and Metformin HydrochlorideActavis Pharma Manufacturing Pvt. Ltd.
Glyburide and MetforminRebel Distributors
Glyburide and Metformin HydrochlorideTeva
Glyburide-metformin HydrochlorideBlenheim Pharmacal, Inc.
InvokametJanssen Pharmaceuticals
Invokamet XRJanssen Pharmaceuticals
JanumetLake Erie Medical &Surgical Supply Dba Quality Care Products Llc
Janumet XRMerck Sharp & Dohme Limited  
JentaduetoPhysicians Total Care, Inc.
Jentadueto XRBoehringer Ingelheim
KazanoTakeda
Kombiglyze XRE.R. Squibb & Sons, L.L.C.
KomboglyzeAstra Zeneca
Pioglitazole and Metformin HydrochlorideMacleods Pharmaceuticals Limited
Pioglitazone and MetforminSandoz
Pioglitazone and Metformin HydrochlorideAv Kare, Inc.
Pioglitazone and Metformin HydrocholrideTeva
Pioglitazone HCl and Metformin HClTorrent Pharmaceuticals Limited
Pioglitazone Hydrochloride and Metformin HydrochlorideAurobindo Pharma
PMS-rosiglitazone-metforminPharmascience Inc
PrandimetNovo Nordisk
Repaglinide and Metformin HydrochlorideLupin Pharmaceuticals
SynjardyBoehringer Ingelheim (Canada) Ltd Ltee
Synjardy XRBoehringer Ingelheim
VelmetiaMerck Sharp & Dohme Limited  
XigduoAstra Zeneca
Xigduo XRAstra Zeneca Lp
Categories
UNII9100L32L2N
CAS number657-24-9
WeightAverage: 129.1636
Monoisotopic: 129.101445377
Chemical FormulaC4H11N5
InChI KeyXZWYZXLIPXDOLR-UHFFFAOYSA-N
InChI
InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)
IUPAC Name
1-carbamimidamido-N,N-dimethylmethanimidamide
SMILES
CN(C)C(=N)NC(N)=N
Pharmacology
Indication

For use as an adjunct to diet and exercise in adult patients (18 years and older) with NIDDM. May also be used for the management of metabolic and reproductive abnormalities associated with polycystic ovary syndrome (PCOS). Jentadueto is for the treatment of patients when both linagliptin and metformin is appropriate.

Structured Indications
Pharmacodynamics

Metformin is an oral antihyperglycemic agent that improves glucose tolerance in patients with NIDDM, lowering both basal and postprandial plasma glucose. Metformin is not chemically or pharmacologically related to any other class of oral antihyperglycemic agents. Unlike sulfonylureas, metformin does not produce hypoglycemia in either patients with NIDDM or healthy subjects and does not cause hyperinsulinemia. Metformin does not affect insulin secretion.

Mechanism of action

Metformin's mechanisms of action differ from other classes of oral antihyperglycemic agents. Metformin decreases blood glucose levels by decreasing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization. These effects are mediated by the initial activation by metformin of AMP-activated protein kinase (AMPK), a liver enzyme that plays an important role in insulin signaling, whole body energy balance, and the metabolism of glucose and fats. Activation of AMPK is required for metformin's inhibitory effect on the production of glucose by liver cells. Increased peripheral utilization of glucose may be due to improved insulin binding to insulin receptors. Metformin administration also increases AMPK activity in skeletal muscle. AMPK is known to cause GLUT4 deployment to the plasma membrane, resulting in insulin-independent glucose uptake. The rare side effect, lactic acidosis, is thought to be caused by decreased liver uptake of serum lactate, one of the substrates of gluconeogenesis. In those with healthy renal function, the slight excess is simply cleared. However, those with severe renal impairment may accumulate clinically significant serum lactic acid levels. Other conditions that may precipitate lactic acidosis include severe hepatic disease and acute/decompensated heart failure.

TargetKindPharmacological actionActionsOrganismUniProt ID
5'-AMP-activated protein kinase subunit beta-1Proteinyes
inducer
HumanQ9Y478 details
Related Articles
Absorption

Absorbed over 6 hours, bioavailability is 50 to 60% under fasting conditions. Administration with food decreases and delays absorption. Some evidence indicates that the level of absorption is not dose-related, suggesting that absorption occurs through a saturable process. Limited data from animal and human cell cultures indicate that absorption occurs through a passive, non-saturable process, possibly involving a paracellular route. Peak action occurs 3 hours after oral administration.

Volume of distribution

654 L for metformin 850 mg administered as a single dose. The volume of distribution following IV administration is 63-276 L, likely due to less binding in the GI tract and/or different methods used to determine volume of distribution.

Protein binding

Metformin is negligibly bound to plasma proteins.

Metabolism

Metformin is not metabolized.

Route of elimination

Intravenous single-dose studies in normal subjects demonstrate that metformin is excreted unchanged in the urine and does not undergo hepatic metabolism (no metabolites have been identified in humans) nor biliary excretion. Approximately 90% of the drug is eliminated in 24 hours in those with healthy renal function. Renal clearance of metformin is approximately 3.5 times that of creatinine clearance, indicating the tubular secretion is the primary mode of metformin elimination.

Half life

6.2 hours. Duration of action is 8-12 hours.

Clearance

718-1552 mL/minute following single oral dose of 0.5-1.5 g. Metformin is removed by hemodialysis at a rate of approximately 170 ml/min under good hemodynamic conditions.

Toxicity

Acute oral toxicity (LD50): 350 mg/kg [Rabbit]. It would be expected that adverse reactions of a more intense character including epigastric discomfort, nausea, and vomiting followed by diarrhea, drowsiness, weakness, dizziness, malaise and headache might be seen.

Affected organisms
  • Humans and other mammals
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypoglycemic activities of Metformin.Experimental
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Metformin.Approved, Vet Approved
Acetylsalicylic acidAcetylsalicylic acid may increase the hypoglycemic activities of Metformin.Approved, Vet Approved
Aminosalicylic AcidAminosalicylic Acid may increase the hypoglycemic activities of Metformin.Approved
AripiprazoleThe therapeutic efficacy of Metformin can be decreased when used in combination with Aripiprazole.Approved, Investigational
Arsenic trioxideThe therapeutic efficacy of Metformin can be decreased when used in combination with Arsenic trioxide.Approved, Investigational
ArticaineThe therapeutic efficacy of Metformin can be decreased when used in combination with Articaine.Approved
AsenapineThe therapeutic efficacy of Metformin can be decreased when used in combination with Asenapine.Approved
AtazanavirThe therapeutic efficacy of Metformin can be decreased when used in combination with Atazanavir.Approved, Investigational
BalsalazideBalsalazide may increase the hypoglycemic activities of Metformin.Approved, Investigational
BendroflumethiazideThe therapeutic efficacy of Metformin can be decreased when used in combination with Bendroflumethiazide.Approved
BenmoxinBenmoxin may increase the hypoglycemic activities of Metformin.Withdrawn
BetamethasoneThe therapeutic efficacy of Metformin can be decreased when used in combination with Betamethasone.Approved, Vet Approved
BrexpiprazoleThe therapeutic efficacy of Metformin can be decreased when used in combination with Brexpiprazole.Approved
BrinzolamideThe risk or severity of adverse effects can be increased when Brinzolamide is combined with Metformin.Approved
BumetanideThe therapeutic efficacy of Metformin can be decreased when used in combination with Bumetanide.Approved
BupropionThe serum concentration of Metformin can be increased when it is combined with Bupropion.Approved
BuserelinThe therapeutic efficacy of Metformin can be decreased when used in combination with Buserelin.Approved
CaroxazoneCaroxazone may increase the hypoglycemic activities of Metformin.Withdrawn
CephalexinThe serum concentration of Metformin can be increased when it is combined with Cephalexin.Approved, Vet Approved
CeritinibThe therapeutic efficacy of Metformin can be decreased when used in combination with Ceritinib.Approved
ChlorothiazideThe therapeutic efficacy of Metformin can be decreased when used in combination with Chlorothiazide.Approved, Vet Approved
ChlorpropamideMetformin may increase the hypoglycemic activities of Chlorpropamide.Approved
ChlorthalidoneThe therapeutic efficacy of Metformin can be decreased when used in combination with Chlorthalidone.Approved
CimetidineThe serum concentration of Metformin can be increased when it is combined with Cimetidine.Approved
CinoxacinCinoxacin may increase the hypoglycemic activities of Metformin.Approved, Withdrawn
CiprofloxacinCiprofloxacin may increase the hypoglycemic activities of Metformin.Approved, Investigational
CitalopramCitalopram may increase the hypoglycemic activities of Metformin.Approved
ClozapineThe therapeutic efficacy of Metformin can be decreased when used in combination with Clozapine.Approved
CorticotropinThe therapeutic efficacy of Metformin can be decreased when used in combination with Corticotropin.Approved, Vet Approved
Cortisone acetateThe therapeutic efficacy of Metformin can be decreased when used in combination with Cortisone acetate.Approved
Cyproterone acetateThe therapeutic efficacy of Metformin can be decreased when used in combination with Cyproterone acetate.Approved, Investigational
DabrafenibThe therapeutic efficacy of Metformin can be decreased when used in combination with Dabrafenib.Approved
DalfampridineThe serum concentration of Dalfampridine can be increased when it is combined with Metformin.Approved
DanazolThe therapeutic efficacy of Metformin can be decreased when used in combination with Danazol.Approved
DapoxetineDapoxetine may increase the hypoglycemic activities of Metformin.Investigational
DarunavirThe therapeutic efficacy of Metformin can be decreased when used in combination with Darunavir.Approved
DesogestrelThe therapeutic efficacy of Metformin can be decreased when used in combination with Desogestrel.Approved
DesvenlafaxineDesvenlafaxine may increase the hypoglycemic activities of Metformin.Approved
DexamethasoneThe therapeutic efficacy of Metformin can be decreased when used in combination with Dexamethasone.Approved, Investigational, Vet Approved
DiatrizoateThe risk or severity of adverse effects can be increased when Diatrizoate is combined with Metformin.Approved, Vet Approved
DiazoxideThe therapeutic efficacy of Metformin can be decreased when used in combination with Diazoxide.Approved
DiclofenamideThe risk or severity of adverse effects can be increased when Diclofenamide is combined with Metformin.Approved
DienogestThe therapeutic efficacy of Metformin can be decreased when used in combination with Dienogest.Approved
DiflunisalDiflunisal may increase the hypoglycemic activities of Metformin.Approved
DihydrotestosteroneDihydrotestosterone may increase the hypoglycemic activities of Metformin.Illicit
DisopyramideMetformin may increase the hypoglycemic activities of Disopyramide.Approved
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Metformin.Approved
DolutegravirThe serum concentration of Metformin can be increased when it is combined with Dolutegravir.Approved
DorzolamideThe risk or severity of adverse effects can be increased when Dorzolamide is combined with Metformin.Approved
DrospirenoneThe therapeutic efficacy of Metformin can be decreased when used in combination with Drospirenone.Approved
DuloxetineDuloxetine may increase the hypoglycemic activities of Metformin.Approved
EnoxacinEnoxacin may increase the hypoglycemic activities of Metformin.Approved
EpinephrineThe therapeutic efficacy of Metformin can be decreased when used in combination with Epinephrine.Approved, Vet Approved
EscitalopramEscitalopram may increase the hypoglycemic activities of Metformin.Approved, Investigational
EstradiolThe therapeutic efficacy of Metformin can be decreased when used in combination with Estradiol.Approved, Investigational, Vet Approved
Estrone sulfateThe therapeutic efficacy of Metformin can be decreased when used in combination with Estrone sulfate.Approved
Etacrynic acidThe therapeutic efficacy of Metformin can be decreased when used in combination with Etacrynic acid.Approved
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Metformin.Approved
Ethinyl EstradiolThe therapeutic efficacy of Metformin can be decreased when used in combination with Ethinyl Estradiol.Approved
Ethiodized oilThe risk or severity of adverse effects can be increased when Ethiodized oil is combined with Metformin.Approved
EthoxzolamideThe risk or severity of adverse effects can be increased when Ethoxzolamide is combined with Metformin.Withdrawn
Ethynodiol diacetateThe therapeutic efficacy of Metformin can be decreased when used in combination with Ethynodiol diacetate.Approved
EtonogestrelThe therapeutic efficacy of Metformin can be decreased when used in combination with Etonogestrel.Approved, Investigational
EtoperidoneEtoperidone may increase the hypoglycemic activities of Metformin.Approved
EverolimusThe therapeutic efficacy of Metformin can be decreased when used in combination with Everolimus.Approved
FleroxacinFleroxacin may increase the hypoglycemic activities of Metformin.Approved
FludrocortisoneThe therapeutic efficacy of Metformin can be decreased when used in combination with Fludrocortisone.Approved
FlumequineFlumequine may increase the hypoglycemic activities of Metformin.Withdrawn
FluoxetineFluoxetine may increase the hypoglycemic activities of Metformin.Approved, Vet Approved
FluoxymesteroneFluoxymesterone may increase the hypoglycemic activities of Metformin.Approved, Illicit
FluvoxamineFluvoxamine may increase the hypoglycemic activities of Metformin.Approved, Investigational
FosamprenavirThe therapeutic efficacy of Metformin can be decreased when used in combination with Fosamprenavir.Approved
FurazolidoneFurazolidone may increase the hypoglycemic activities of Metformin.Approved, Vet Approved
FurosemideThe therapeutic efficacy of Metformin can be decreased when used in combination with Furosemide.Approved, Vet Approved
GatifloxacinGatifloxacin may increase the hypoglycemic activities of Metformin.Approved, Investigational
GemifloxacinGemifloxacin may increase the hypoglycemic activities of Metformin.Approved, Investigational
GliclazideMetformin may increase the hypoglycemic activities of Gliclazide.Approved
GlimepirideMetformin may increase the hypoglycemic activities of Glimepiride.Approved
GlipizideMetformin may increase the hypoglycemic activities of Glipizide.Approved
GlyburideMetformin may increase the hypoglycemic activities of Glyburide.Approved
GlycopyrroniumThe serum concentration of Metformin can be increased when it is combined with Glycopyrronium.Approved, Investigational, Vet Approved
GoserelinThe therapeutic efficacy of Metformin can be decreased when used in combination with Goserelin.Approved
GrepafloxacinGrepafloxacin may increase the hypoglycemic activities of Metformin.Withdrawn
HistrelinThe therapeutic efficacy of Metformin can be decreased when used in combination with Histrelin.Approved
HydracarbazineHydracarbazine may increase the hypoglycemic activities of Metformin.Approved
HydrochlorothiazideThe therapeutic efficacy of Metformin can be decreased when used in combination with Hydrochlorothiazide.Approved, Vet Approved
HydrocortisoneThe therapeutic efficacy of Metformin can be decreased when used in combination with Hydrocortisone.Approved, Vet Approved
HydroflumethiazideThe therapeutic efficacy of Metformin can be decreased when used in combination with Hydroflumethiazide.Approved
Hydroxyprogesterone caproateThe therapeutic efficacy of Metformin can be decreased when used in combination with Hydroxyprogesterone caproate.Approved
IloperidoneThe therapeutic efficacy of Metformin can be decreased when used in combination with Iloperidone.Approved
IndalpineIndalpine may increase the hypoglycemic activities of Metformin.Investigational, Withdrawn
IndapamideThe therapeutic efficacy of Metformin can be decreased when used in combination with Indapamide.Approved
IndinavirThe therapeutic efficacy of Metformin can be decreased when used in combination with Indinavir.Approved
Insulin AspartMetformin may increase the hypoglycemic activities of Insulin Aspart.Approved
Insulin DetemirMetformin may increase the hypoglycemic activities of Insulin Detemir.Approved
Insulin GlargineMetformin may increase the hypoglycemic activities of Insulin Glargine.Approved
Insulin GlulisineMetformin may increase the hypoglycemic activities of Insulin Glulisine.Approved
Insulin HumanMetformin may increase the hypoglycemic activities of Insulin Human.Approved, Investigational
Insulin LisproMetformin may increase the hypoglycemic activities of Insulin Lispro.Approved
IodipamideThe risk or severity of adverse effects can be increased when Iodipamide is combined with Metformin.Approved
IodixanolThe risk or severity of adverse effects can be increased when Iodixanol is combined with Metformin.Approved
IohexolThe risk or severity of adverse effects can be increased when Iohexol is combined with Metformin.Approved
IopamidolThe risk or severity of adverse effects can be increased when Iopamidol is combined with Metformin.Approved
IopromideThe risk or severity of adverse effects can be increased when Iopromide is combined with Metformin.Approved
IoversolThe risk or severity of adverse effects can be increased when Ioversol is combined with Metformin.Approved
IoxilanThe risk or severity of adverse effects can be increased when Ioxilan is combined with Metformin.Approved
IproclozideIproclozide may increase the hypoglycemic activities of Metformin.Withdrawn
IproniazidIproniazid may increase the hypoglycemic activities of Metformin.Withdrawn
IsocarboxazidIsocarboxazid may increase the hypoglycemic activities of Metformin.Approved
LamotrigineThe serum concentration of Metformin can be increased when it is combined with Lamotrigine.Approved, Investigational
LanreotideThe therapeutic efficacy of Metformin can be decreased when used in combination with Lanreotide.Approved
LeuprolideThe therapeutic efficacy of Metformin can be decreased when used in combination with Leuprolide.Approved, Investigational
LevofloxacinLevofloxacin may increase the hypoglycemic activities of Metformin.Approved, Investigational
LevomilnacipranLevomilnacipran may increase the hypoglycemic activities of Metformin.Approved
LevonorgestrelThe therapeutic efficacy of Metformin can be decreased when used in combination with Levonorgestrel.Approved, Investigational
Lipoic AcidLipoic Acid may increase the hypoglycemic activities of Metformin.Approved, Nutraceutical
LomefloxacinLomefloxacin may increase the hypoglycemic activities of Metformin.Approved
LopinavirThe therapeutic efficacy of Metformin can be decreased when used in combination with Lopinavir.Approved
LurasidoneThe therapeutic efficacy of Metformin can be decreased when used in combination with Lurasidone.Approved
MebanazineMebanazine may increase the hypoglycemic activities of Metformin.Withdrawn
MecaserminMetformin may increase the hypoglycemic activities of Mecasermin.Approved, Investigational
Medroxyprogesterone acetateThe therapeutic efficacy of Metformin can be decreased when used in combination with Medroxyprogesterone acetate.Approved, Investigational
Megestrol acetateThe therapeutic efficacy of Metformin can be decreased when used in combination with Megestrol acetate.Approved, Vet Approved
MesalazineMesalazine may increase the hypoglycemic activities of Metformin.Approved
MestranolThe therapeutic efficacy of Metformin can be decreased when used in combination with Mestranol.Approved
MethazolamideThe risk or severity of adverse effects can be increased when Methazolamide is combined with Metformin.Approved
MethotrimeprazineThe therapeutic efficacy of Metformin can be decreased when used in combination with Methotrimeprazine.Approved
MethyclothiazideThe therapeutic efficacy of Metformin can be decreased when used in combination with Methyclothiazide.Approved
Methylene blueMethylene blue may increase the hypoglycemic activities of Metformin.Investigational
MethylprednisoloneThe therapeutic efficacy of Metformin can be decreased when used in combination with Methylprednisolone.Approved, Vet Approved
MethyltestosteroneMethyltestosterone may increase the hypoglycemic activities of Metformin.Approved
MetolazoneThe therapeutic efficacy of Metformin can be decreased when used in combination with Metolazone.Approved
MifepristoneMetformin may increase the hypoglycemic activities of Mifepristone.Approved, Investigational
MilnacipranMilnacipran may increase the hypoglycemic activities of Metformin.Approved
MinaprineMinaprine may increase the hypoglycemic activities of Metformin.Approved
MoclobemideMoclobemide may increase the hypoglycemic activities of Metformin.Approved
MoxifloxacinMoxifloxacin may increase the hypoglycemic activities of Metformin.Approved, Investigational
Nalidixic AcidNalidixic Acid may increase the hypoglycemic activities of Metformin.Approved
NateglinideMetformin may increase the hypoglycemic activities of Nateglinide.Approved, Investigational
NCX 4016NCX 4016 may increase the hypoglycemic activities of Metformin.Investigational
NefazodoneNefazodone may increase the hypoglycemic activities of Metformin.Approved, Withdrawn
NelfinavirThe therapeutic efficacy of Metformin can be decreased when used in combination with Nelfinavir.Approved
NiacinThe therapeutic efficacy of Metformin can be decreased when used in combination with Niacin.Approved, Investigational, Nutraceutical
NialamideNialamide may increase the hypoglycemic activities of Metformin.Withdrawn
NilotinibThe therapeutic efficacy of Metformin can be decreased when used in combination with Nilotinib.Approved, Investigational
NorethisteroneThe therapeutic efficacy of Metformin can be decreased when used in combination with Norethisterone.Approved
NorfloxacinNorfloxacin may increase the hypoglycemic activities of Metformin.Approved
NorgestimateThe therapeutic efficacy of Metformin can be decreased when used in combination with Norgestimate.Approved
OctamoxinOctamoxin may increase the hypoglycemic activities of Metformin.Withdrawn
OctreotideThe therapeutic efficacy of Metformin can be decreased when used in combination with Octreotide.Approved, Investigational
OfloxacinOfloxacin may increase the hypoglycemic activities of Metformin.Approved
OlanzapineThe therapeutic efficacy of Metformin can be decreased when used in combination with Olanzapine.Approved, Investigational
OlsalazineOlsalazine may increase the hypoglycemic activities of Metformin.Approved
OxandroloneOxandrolone may increase the hypoglycemic activities of Metformin.Approved, Investigational
OxymetholoneOxymetholone may increase the hypoglycemic activities of Metformin.Approved, Illicit
PaliperidoneThe therapeutic efficacy of Metformin can be decreased when used in combination with Paliperidone.Approved
PargylinePargyline may increase the hypoglycemic activities of Metformin.Approved
ParoxetineParoxetine may increase the hypoglycemic activities of Metformin.Approved, Investigational
PasireotideThe therapeutic efficacy of Metformin can be decreased when used in combination with Pasireotide.Approved
PefloxacinPefloxacin may increase the hypoglycemic activities of Metformin.Approved
PegvisomantPegvisomant may increase the hypoglycemic activities of Metformin.Approved
PentamidineThe therapeutic efficacy of Metformin can be decreased when used in combination with Pentamidine.Approved
PhenelzinePhenelzine may increase the hypoglycemic activities of Metformin.Approved
PheniprazinePheniprazine may increase the hypoglycemic activities of Metformin.Withdrawn
PhenoxypropazinePhenoxypropazine may increase the hypoglycemic activities of Metformin.Withdrawn
PiperazineThe therapeutic efficacy of Metformin can be decreased when used in combination with Piperazine.Approved, Vet Approved
PipotiazineThe therapeutic efficacy of Metformin can be decreased when used in combination with Pipotiazine.Approved
PirlindolePirlindole may increase the hypoglycemic activities of Metformin.Approved
PivhydrazinePivhydrazine may increase the hypoglycemic activities of Metformin.Withdrawn
PolythiazideThe therapeutic efficacy of Metformin can be decreased when used in combination with Polythiazide.Approved
PrednisoloneThe therapeutic efficacy of Metformin can be decreased when used in combination with Prednisolone.Approved, Vet Approved
PrednisoneThe therapeutic efficacy of Metformin can be decreased when used in combination with Prednisone.Approved, Vet Approved
ProgesteroneThe therapeutic efficacy of Metformin can be decreased when used in combination with Progesterone.Approved, Vet Approved
QuetiapineThe therapeutic efficacy of Metformin can be decreased when used in combination with Quetiapine.Approved
QuinethazoneThe therapeutic efficacy of Metformin can be decreased when used in combination with Quinethazone.Approved
QuinineMetformin may increase the hypoglycemic activities of Quinine.Approved
RanolazineThe serum concentration of Metformin can be increased when it is combined with Ranolazine.Approved, Investigational
RasagilineRasagiline may increase the hypoglycemic activities of Metformin.Approved
RepaglinideMetformin may increase the hypoglycemic activities of Repaglinide.Approved, Investigational
RisperidoneThe therapeutic efficacy of Metformin can be decreased when used in combination with Risperidone.Approved, Investigational
RitonavirThe therapeutic efficacy of Metformin can be decreased when used in combination with Ritonavir.Approved, Investigational
RosoxacinRosoxacin may increase the hypoglycemic activities of Metformin.Approved
SafrazineSafrazine may increase the hypoglycemic activities of Metformin.Withdrawn
Salicylic acidSalicylic acid may increase the hypoglycemic activities of Metformin.Approved, Vet Approved
SaquinavirThe therapeutic efficacy of Metformin can be decreased when used in combination with Saquinavir.Approved, Investigational
SelegilineSelegiline may increase the hypoglycemic activities of Metformin.Approved, Investigational, Vet Approved
SertralineSertraline may increase the hypoglycemic activities of Metformin.Approved
SirolimusThe therapeutic efficacy of Metformin can be decreased when used in combination with Sirolimus.Approved, Investigational
SparfloxacinSparfloxacin may increase the hypoglycemic activities of Metformin.Approved
StanozololStanozolol may increase the hypoglycemic activities of Metformin.Approved, Vet Approved
SulfadiazineMetformin may increase the hypoglycemic activities of Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleMetformin may increase the hypoglycemic activities of Sulfamethoxazole.Approved
SulfisoxazoleMetformin may increase the hypoglycemic activities of Sulfisoxazole.Approved, Vet Approved
SunitinibMetformin may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
TacrolimusThe therapeutic efficacy of Metformin can be decreased when used in combination with Tacrolimus.Approved, Investigational
TemafloxacinTemafloxacin may increase the hypoglycemic activities of Metformin.Withdrawn
TemsirolimusThe therapeutic efficacy of Metformin can be decreased when used in combination with Temsirolimus.Approved
TestosteroneTestosterone may increase the hypoglycemic activities of Metformin.Approved, Investigational
TipranavirThe therapeutic efficacy of Metformin can be decreased when used in combination with Tipranavir.Approved, Investigational
TolazamideMetformin may increase the hypoglycemic activities of Tolazamide.Approved
TolbutamideMetformin may increase the hypoglycemic activities of Tolbutamide.Approved
ToloxatoneToloxatone may increase the hypoglycemic activities of Metformin.Approved
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Metformin.Approved
TorasemideThe therapeutic efficacy of Metformin can be decreased when used in combination with Torasemide.Approved
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypoglycemic activities of Metformin.Experimental
TranylcypromineTranylcypromine may increase the hypoglycemic activities of Metformin.Approved
TriamcinoloneThe therapeutic efficacy of Metformin can be decreased when used in combination with Triamcinolone.Approved, Vet Approved
TrichlormethiazideThe therapeutic efficacy of Metformin can be decreased when used in combination with Trichlormethiazide.Approved, Vet Approved
TrimethoprimThe serum concentration of Metformin can be increased when it is combined with Trimethoprim.Approved, Vet Approved
TriptorelinThe therapeutic efficacy of Metformin can be decreased when used in combination with Triptorelin.Approved, Vet Approved
TrospiumThe serum concentration of Trospium can be decreased when it is combined with Metformin.Approved
TrovafloxacinTrovafloxacin may increase the hypoglycemic activities of Metformin.Approved, Withdrawn
VandetanibThe serum concentration of Metformin can be increased when it is combined with Vandetanib.Approved
VenlafaxineVenlafaxine may increase the hypoglycemic activities of Metformin.Approved
VerapamilThe therapeutic efficacy of Metformin can be decreased when used in combination with Verapamil.Approved
VorinostatThe therapeutic efficacy of Metformin can be decreased when used in combination with Vorinostat.Approved, Investigational
ZimelidineZimelidine may increase the hypoglycemic activities of Metformin.Withdrawn
ZiprasidoneThe therapeutic efficacy of Metformin can be decreased when used in combination with Ziprasidone.Approved
Food Interactions
  • Avoid alcohol.
  • Take with food to reduce gastric irritation.
References
Synthesis Reference

Jorn Moeckel, Rolf-Dieter Gabel, Heinrich Woog, “Pharmaceutical preparation containing metformin and a process for producing it.” U.S. Patent US5955106, issued October, 1991.

US5955106
General References
  1. Witters LA: The blooming of the French lilac. J Clin Invest. 2001 Oct;108(8):1105-7. [PubMed:11602616 ]
  2. UNGAR G, FREEDMAN L, SHAPIRO SL: Pharmacological studies of a new oral hypoglycemic drug. Proc Soc Exp Biol Med. 1957 May;95(1):190-2. [PubMed:13432032 ]
  3. Lord JM, Flight IH, Norman RJ: Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ. 2003 Oct 25;327(7421):951-3. [PubMed:14576245 ]
  4. Marchesini G, Brizi M, Bianchi G, Tomassetti S, Zoli M, Melchionda N: Metformin in non-alcoholic steatohepatitis. Lancet. 2001 Sep 15;358(9285):893-4. [PubMed:11567710 ]
  5. Nair S, Diehl AM, Wiseman M, Farr GH Jr, Perrillo RP: Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial. Aliment Pharmacol Ther. 2004 Jul 1;20(1):23-8. [PubMed:15225167 ]
External Links
ATC CodesA10BD13A10BD18A10BA02A10BD03A10BD16A10BD10A10BD02A10BD14A10BD15A10BD08A10BD05A10BD20A10BD11A10BD17A10BD07
AHFS Codes
  • 68:20.04
PDB EntriesNot Available
FDA labelDownload (239 KB)
MSDSDownload (73.8 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingSupportive CareThyroid1
0Active Not RecruitingTreatmentEndometrial Hyperplasia / Endometrial Hyperplasia Without Atypia1
0CompletedBasic ScienceCardiovascular Disease (CVD)1
0CompletedBasic ScienceHead and Neck Squamous Cell Cancer1
0CompletedPreventionLong Segment Barrett's Esophagus / Short Segment Barrett's Esophagus1
0CompletedPreventionPolycystic Ovaries Syndrome1
0CompletedTreatmentDiet Tolerability / Fasting Glucose / Metformin Concentration / Metformin Response / Tryptophan Concentration1
0CompletedTreatmentEndometrial Cancers1
0CompletedTreatmentPolycystic Ovaries Syndrome1
0Not Yet RecruitingOtherGlioblastomas1
0Not Yet RecruitingPreventionAtrophy, Disuse / Insulin Resistance1
0RecruitingPreventionRetinopathy, Diabetic1
0RecruitingSupportive CareLarynx / LIP / Oral Cavity / Pharynx1
0RecruitingTreatmentAcinar Cell Adenocarcinoma of the Pancreas / Duct Cell Adenocarcinoma of the Pancreas / Recurrent Pancreatic Cancer / Stage I-III Pancreatic Cancer1
0RecruitingTreatmentCancer of Breast / Cancer, Breast / Tumors, Breast1
0RecruitingTreatmentHemoglobin Disease; Sickle-Cell, Thalassemia / Hemoglobin Disorder / Sickle Cell Anemia / Sickle Cells Disease1
0RecruitingTreatmentNeuroendocrine Tumors1
0TerminatedBasic ScienceCancer of Head and Neck1
0Unknown StatusTreatmentPolycystic Ovarian Syndrome1
1Active Not RecruitingBasic ScienceType 2 Diabetes Mellitus (T2D)1
1Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)1
1Active Not RecruitingTreatmentAdult Acute Megakaryoblastic Leukemia (M7) / Adult Acute Minimally Differentiated Myeloid Leukemia (M0) / Adult Acute Monoblastic Leukemia (M5a) / Adult Acute Monocytic Leukemia (M5b) / Adult Acute Myeloblastic Leukemia With Maturation (M2) / Adult Acute Myeloblastic Leukemia Without Maturation (M1) / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Acute Myelomonocytic Leukemia (M4) / Adult Erythroleukemia (M6a) / Adult Pure Erythroid Leukemia (M6b) / Blastic Phase Chronic Myelogenous Leukemia / Recurrent Adult Acute Myeloid Leukemia / Untreated Adult Acute Myeloid Leukemia1
1Active Not RecruitingTreatmentBrain Cancer1
1Active Not RecruitingTreatmentCancer, Breast1
1CompletedNot AvailableBMI >30 kg/m21
1CompletedNot AvailableDepression / Type 2 Diabetes Mellitus (T2D)1
1CompletedNot AvailableDiabetes1
1CompletedNot AvailableDiabetes Mellitus (DM)2
1CompletedNot AvailableDiabetes Mellitus (DM) / Hepatitis C / Insulin Resistance1
1CompletedNot AvailableDiabetes / Healthy Male and Female Subjects1
1CompletedNot AvailableHealthy Male Volunteers1
1CompletedNot AvailableHealthy Volunteers29
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Metformin1
1CompletedNot AvailableType 2 Diabetes Mellitus (T2D)14
1CompletedBasic ScienceHealthy Volunteers12
1CompletedBasic SciencePreDiabetes1
1CompletedBasic ScienceType 2 Diabetes Mellitus (T2D)3
1CompletedDiagnosticHealthy Volunteers1
1CompletedDiagnosticHealthy Volunteers / Type 2 Diabetes Mellitus (T2D)1
1CompletedHealth Services ResearchHealthy Volunteers1
1CompletedOtherHealthy Volunteers2
1CompletedPreventionDiabetes1
1CompletedSupportive CareHealthy Volunteers1
1CompletedTreatmentAdvanced Cancers1
1CompletedTreatmentBioequivalence1
1CompletedTreatmentCancer, Breast1
1CompletedTreatmentCancer, Breast / Endometrial Cancers / Kidney Cancer / Lung Cancers / Lymphoma NOS / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentCancers1
1CompletedTreatmentDiabetes / Healthy Volunteers2
1CompletedTreatmentDiabetes / Healthy Volunteers / Type 2 Diabetes Mellitus (T2D)1
1CompletedTreatmentDiabetes / Hyperlipidemias1
1CompletedTreatmentDiabetes / Type 2 Diabetes Mellitus (T2D)2
1CompletedTreatmentDuchenne's Muscular Dystrophy (DMD)1
1CompletedTreatmentHealthy Elderly1
1CompletedTreatmentHealthy Participants1
1CompletedTreatmentHealthy Volunteers45
1CompletedTreatmentLi-Fraumeni Syndrome1
1CompletedTreatmentPain, Neuropathic1
1CompletedTreatmentType 2 Diabetes Mellitus (T2D)20
1CompletedTreatmentType2 Diabetes Mellitus1
1Enrolling by InvitationTreatmentHealthy Volunteers1
1Not Yet RecruitingTreatmentCancer, Advanced / Tumors, Solid1
1Not Yet RecruitingTreatmentCancer, Breast1
1Not Yet RecruitingTreatmentType 2 Diabetes Mellitus (T2D)2
1RecruitingBasic ScienceAging1
1RecruitingBasic ScienceNon-Alcoholic Fatty Liver Disease (NAFLD)1
1RecruitingBasic ScienceType 2 Diabetes Mellitus (T2D)1
1RecruitingTreatmentAbnormal Liver Function Tests / BMI >27 kg/m21
1RecruitingTreatmentAdenocarcinoma of the Pancreas / Metastatic Pancreatic Adenocarcinoma / Stage IV Pancreatic Cancer / Unresectable Pancreatic Carcinoma1
1RecruitingTreatmentAdvanced Cancers1
1RecruitingTreatmentCarcinoma of the Prostate1
1RecruitingTreatmentDiabetes Insipidus1
1RecruitingTreatmentDiabetes / Hyperlipidemias1
1RecruitingTreatmentEpithelial Ovarian Cancer1
1RecruitingTreatmentHead and Neck Cancers1
1RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
1RecruitingTreatmentNeoplasms, Brain1
1RecruitingTreatmentNon-Alcoholic Fatty Liver Disease (NAFLD)1
1RecruitingTreatmentPolycystic Ovarian Syndrome1
1RecruitingTreatmentPrimary Brain Tumors / Tumors, Solid1
1RecruitingTreatmentType 2 Diabetes Mellitus (T2D)1
1TerminatedNot AvailableCarcinoma, Colorectal1
1TerminatedNot AvailableGeneralized Anxiety Disorder (GAD)1
1TerminatedNot AvailableType 2 Diabetes Mellitus (T2D)1
1TerminatedTreatmentColon Cancer1
1TerminatedTreatmentType 2 Diabetes Mellitus (T2D)1
1Unknown StatusTreatmentBMI >30 kg/m2 / Psychotropic Induced Weight Gain / Weight gain therapy1
1Unknown StatusTreatmentDiabetes Mellitus, Non-Insulin-Dependent / Hypertriglyceridemias1
1Unknown StatusTreatmentType 2 Diabetes Mellitus (T2D)1
1WithdrawnNot AvailableComparative Bioavailability1
1WithdrawnNot AvailableType 2 Diabetes Mellitus (T2D)1
1WithdrawnTreatmentOvarian Papillary Serous Carcinoma / Ovarian Serous Cystadenocarcinoma / Recurrent Fallopian Tube Cancer / Recurrent Ovarian Epithelial Cancer / Recurrent Ovarian Germ Cell Tumor / Recurrent Primary Peritoneal Cavity Cancer1
1WithdrawnTreatmentStage IA Pancreatic Cancer / Stage IB Pancreatic Cancer / Stage IIA Pancreatic Cancer / Stage IIB Pancreatic Cancer1
1, 2Active Not RecruitingOtherPreDiabetes1
1, 2CompletedNot AvailableNonalcoholic Fatty Liver Disease1
1, 2CompletedBasic ScienceType 2 Diabetes Mellitus (T2D)1
1, 2CompletedDiagnosticType 2 Diabetes Mellitus (T2D)1
1, 2CompletedTreatmentHyperlactacidaemia1
1, 2CompletedTreatmentInsulin Resistance / Low Milk Supply / Pre-Diabetes / Suppressed Lactation1
1, 2CompletedTreatmentStage IV Pancreatic Cancer1
1, 2CompletedTreatmentType 2 Diabetes Mellitus (T2D)2
1, 2Not Yet RecruitingTreatmentRecurrent Endometrial Cancer1
1, 2RecruitingBasic SciencePolycystic Ovaries Syndrome1
1, 2RecruitingTreatmentCholangiocarcinomas / Chondrosarcomas / Gliomas1
1, 2RecruitingTreatmentHead and Neck Squamous Cell Carcinoma (HNSCC)1
1, 2RecruitingTreatmentHereditary Leiomyomatosis and Renal Cell Cancer / Papillary Renal Cell Carcinoma, Sporadic / Renal Cell Carcinoma (RCC)1
1, 2RecruitingTreatmentMelanoma2
1, 2RecruitingTreatmentMetastatic Pancreatic Adenocarcinoma1
1, 2Unknown StatusTreatmentGestational Diabetes Mellitus (GDM)1
2Active Not RecruitingDiagnosticCancer, Breast / Colorectal Cancers1
2Active Not RecruitingPreventionCancer, Breast / Carcinoma of the Prostate / Colon Cancer / Endometrial Cancers / Kidney Cancer / Liver Cancer / Lung Cancers / Melanoma of Skin / Other Solid Malignant Tumors / Pancreatic Cancers / Rectal Cancers1
2Active Not RecruitingPreventionNeoplasms, Lung / Non-Small-Cell Lung Carcinoma (NSCLC)1
2Active Not RecruitingTreatmentAdenocarcinoma of the Lung / Adenosquamous Lung Carcinoma / Bronchioloalveolar Carcinoma / Large Cell Lung Carcinoma / Non-Small Cell Lung Carcinoma (NSCLC) / Recurrent Non-Small Cell Lung Carcinoma / Squamous Cell Lung Carcinoma / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIB Non-Small Cell Lung Cancer1
2Active Not RecruitingTreatmentAdenocarcinoma of the Lung / Non-Small-Cell Lung Carcinoma (NSCLC)1
2Active Not RecruitingTreatmentCancer, Advanced / EGFR Gene Amplification / Non-Small-Cell Lung Carcinoma (NSCLC) / Stage IIIB NSCLC / Stage IV NSCLC1
2Active Not RecruitingTreatmentCancer, Breast1
2Active Not RecruitingTreatmentCarcinoma of the Prostate1
2Active Not RecruitingTreatmentDiastolic Dysfunction / Insulin Resistance / Metabolic Syndromes1
2Active Not RecruitingTreatmentEndometrial Cancers1
2Active Not RecruitingTreatmentMetastatic Breast Cancer (MBC)1
2Active Not RecruitingTreatmentNAFLD1
2Active Not RecruitingTreatmentOvarian, Fallopian Tube, and Primary Peritoneal Cancer1
2Active Not RecruitingTreatmentProstatic Neoplasms1
2Active Not RecruitingTreatmentRectal Cancers1
2CompletedBasic ScienceCancer, Breast1
2CompletedBasic ScienceDiabetic Foot1
2CompletedDiagnosticFibromyalgia / Mitochondrial Diseases / Movement Disorders / Type 2 Diabetes Mellitus (T2D)1
2CompletedDiagnosticMetabolic Syndromes1
2CompletedPreventionAdenomatous Polyps / BMI >30 kg/m2 / Colorectal Cancers1
2CompletedPreventionAmnestic Mild Cognitive Impairment1
2CompletedPreventionCancer, Breast1
2CompletedPreventionEsophageal Cancers / Esophagus, Barrett1
2CompletedPreventionHypercholesterolaemia / Metabolic Syndromes1
2CompletedPreventionType 2 Diabetes Mellitus (T2D)1
2CompletedPreventionWeight gain therapy1
2CompletedTreatmentAdenocarcinoma of the Prostate / Recurrent Prostate Cancer / Stage I Prostate Cancer / Stage IIA Prostate Cancer / Stage IIB Prostate Cancer1
2CompletedTreatmentAlzheimer's Disease (AD) / Dementia, Vascular / Dementias / Memory Impairment1
2CompletedTreatmentBMI >30 kg/m23
2CompletedTreatmentBMI >30 kg/m2 / Hypercholesterolaemia / Hyperglycemias / Hypertensive1
2CompletedTreatmentBMI >30 kg/m2 / Hyperinsulinemia1
2CompletedTreatmentBMI >30 kg/m2 / Hyperinsulinemia / Insulin Resistance1
2CompletedTreatmentBecker's Muscular Dystrophy (BMD)1
2CompletedTreatmentCarcinoma of the Prostate1
2CompletedTreatmentCongestive Heart Failure (CHF) / Type 2 Diabetes Mellitus (T2D)1
2CompletedTreatmentDiabetes Mellitus (DM)1
2CompletedTreatmentDiabetes Mellitus (DM) / Endocrine System Diseases / Nutritional and Metabolic Diseases / Type 2 Diabetes Mellitus (T2D)1
2CompletedTreatmentDiabetes Mellitus (DM) / Glucose Metabolism Disorders / Type 2 Diabetes Mellitus (T2D)1
2CompletedTreatmentDiabetes Mellitus (DM) / Insulin Resistance1
2CompletedTreatmentDiabetes / Type 2 Diabetes Mellitus (T2D)6
2CompletedTreatmentHepatitis1
2CompletedTreatmentHuman Epidermal Growth Factor 2 Negative Carcinoma of Breast1
2CompletedTreatmentHypothalamic Obesity1
2CompletedTreatmentImpaired Glucose Tolerance (IGT) / Type 2 Diabetes Mellitus (T2D)1
2CompletedTreatmentInsulin Resistance / Metabolic Syndromes / Type 2 Diabetes Mellitus (T2D)1
2CompletedTreatmentInsulin Resistance / Post-Menopausal1
2CompletedTreatmentLocally Advanced Pancreatic Cancer / Pancreatic Cancer Metastatic1
2CompletedTreatmentMetastatic Colorectal Cancers1
2CompletedTreatmentNon Insulin Dependent Diabetes / Pregnancy1
2CompletedTreatmentPancreatic Adenocarcinoma Advanced or Metastatic1
2CompletedTreatmentPatients With Metabolic Syndrome1
2CompletedTreatmentPeriodontitis1
2CompletedTreatmentPolycystic Ovarian Syndrome1
2CompletedTreatmentPolycystic Ovarian Syndrome / Reproductive Endocrinology1
2CompletedTreatmentPolycystic Ovaries Syndrome2
2CompletedTreatmentRenal Disorder Associated With Type II Diabetes Mellitus1
2CompletedTreatmentType 2 Diabetes Mellitus (T2D)35
2Enrolling by InvitationTreatmentEndometrial Cancers1
2Enrolling by InvitationTreatmentHyperandrogenism / Polycystic Ovaries Syndrome1
2Not Yet RecruitingPreventionTertiary Prevention in Colon Cancer1
2Not Yet RecruitingTreatmentAdenocarcinomas / Neoplasms, Colorectal1
2Not Yet RecruitingTreatmentCarcinoma of the Prostate1
2Not Yet RecruitingTreatmentHepatitis C / Human Immunodeficiency Virus (HIV) Infections1
2Not Yet RecruitingTreatmentInfertility Female1
2Not Yet RecruitingTreatmentNeoplasms, Oropharyngeal / Oral Cavity Neoplasm / Stage I Oral Cavity Squamous Cell Carcinoma / Stage I Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage I Oropharyngeal Squamous Cell Carcinoma / Stage I Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7 / Stage II Oral Cavity Squamous Cell Carcinoma / Stage II Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage II Oropharyngeal Squamous Cell Carcinoma / Stage II Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7 / Stage III Oral Cavity Squamous Cell Carcinoma / Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage III Oropharyngeal Squamous Cell Carcinoma / Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IVA Oral Cavity Squamous Cell Carcinoma / Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage IVA Oropharyngeal Squamous Cell Carcinoma / Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IVB Oral Cavity Squamous Cell Carcinoma / Stage IVB Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage IVB Oropharyngeal Squamous Cell Carcinoma / Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IVC Oral Cavity Squamous Cell Carcinoma / Stage IVC Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage IVC Oropharyngeal Squamous Cell Carcinoma / Stage IVC Oropharyngeal Squamous Cell Carcinoma AJCC v71
2Not Yet RecruitingTreatmentRecurrent Non-Small Cell Lung Carcinoma / Stage III Non-Small Cell Lung Cancer / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIB Non-Small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer1
2Not Yet RecruitingTreatmentRenal Insufficiency,Chronic2
2Not Yet RecruitingTreatmentResectable Pancreatic Ductal Adenocarcinoma1
2RecruitingBasic SciencePhysical Activity1
2RecruitingPreventionBMI >30 kg/m2 / Prediabetic State1
2RecruitingPreventionBreast Cancer Prevention1
2RecruitingPreventionCancer, Breast / Tumors, Breast1
2RecruitingPreventionErythroplakia / Hyperplasia / Mild Dysplasia / Moderate Dysplasia / Oral Cavity Carcinoma / Oral Leukoplakia / Severe Dysplasia1
2RecruitingPreventionFrailty1
2RecruitingPreventionIntracytoplasmatic Sperm Injection1
2RecruitingTreatmentAcinar Cell Adenocarcinoma of the Pancreas / Duct Cell Adenocarcinoma of the Pancreas / Recurrent Pancreatic Cancer / Stage IV Pancreatic Cancer1
2RecruitingTreatmentAdenocarcinoma of the Endometrium1
2RecruitingTreatmentAdenocarcinomas / Carcinoma, Adenosquamous / Squamous Cell Carcinoma (SCC) / Uterine Cervical Neoplasms1
2RecruitingTreatmentAdenocarcinomas / Carcinomas / Rectal Neoplasms1
2RecruitingTreatmentAge-Related Macular Degeneration (ARMD) / Dry Macular Degeneration / Geographic Atrophy / Macular Degeneration, Age-Related1
2RecruitingTreatmentBCT Rate / PCR Rate / Safety1
2RecruitingTreatmentBladder Cancers1
2RecruitingTreatmentBrenner Tumor / Malignant Ascites / Malignant Pleural Effusions / Ovarian Clear Cell Cystadenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Mixed Epithelial Carcinoma / Ovarian Serous Cystadenocarcinoma / Ovarian Undifferentiated Adenocarcinoma / Recurrent Fallopian Tube Cancer / Recurrent Ovarian Epithelial Cancer / Recurrent Ovarian Germ Cell Tumor / Recurrent Primary Peritoneal Cavity Cancer / Stage IIIA Fallopian Tube Cancer / Stage IIIA Ovarian Epithelial Cancer / Stage IIIA Ovarian Germ Cell Tumor / Stage IIIA Primary Peritoneal Cavity Cancer / Stage IIIB Fallopian Tube Cancer / Stage IIIB Ovarian Epithelial Cancer / Stage IIIB Ovarian Germ Cell Tumor / Stage IIIB Primary Peritoneal Cavity Cancer / Stage IIIC Fallopian Tube Cancer / Stage IIIC Ovarian Epithelial Cancer / Stage IIIC Ovarian Germ Cell Tumor / Stage IIIC Primary Peritoneal Cavity Cancer / Stage IV Fallopian Tube Cancer / Stage IV Ovarian Epithelial Cancer / Stage IV Ovarian Germ Cell Tumor / Stage IV Primary Peritoneal Cavity Cancer1
2RecruitingTreatmentCancer of the PROSTATE / Carcinoma of the Prostate1
2RecruitingTreatmentCancer, Breast2
2RecruitingTreatmentCarcinoma of the Prostate4
2RecruitingTreatmentCarcinoma of the Prostate / Prostate Cancer Recurrent1
2RecruitingTreatmentCarcinoma, Breast / Endometrial Clear Cell Adenocarcinoma / Endometrial Serous Adenocarcinoma / Uterine Corpus Cancer / Uterine Corpus Carcinosarcoma1
2RecruitingTreatmentCarcinoma, Non-squamous Non-small-cell Lung1
2RecruitingTreatmentCardiovascular Disease (CVD) / Chronic Kidney Disease (CKD) / Metabolic Syndromes1
2RecruitingTreatmentComplex Endometrial Hyperplasia With Atypia / Grade 1 Endometrial Endometrioid Adenocarcinoma1
2RecruitingTreatmentCoronary Artery Disease / HIV Disease1
2RecruitingTreatmentDiffuse Large B-Cell Lymphoma (DLBCL)1
2RecruitingTreatmentEndometrial Adenocarcinomas / Endometrial Atypical Hyperplasia1
2RecruitingTreatmentEpithelial Ovarian Carcinoma1
2RecruitingTreatmentGlioblastoma Multiforme1
2RecruitingTreatmentHER-2 Positive Breast Cancer1
2RecruitingTreatmentHeart Failure, Systolic1
2RecruitingTreatmentHepatocellular Carcinomas1
2RecruitingTreatmentHormone Receptor Positive Malignant Neoplasm of Breast1
2RecruitingTreatmentHyperandrogenism / Insulin Resistance / Polycystic Ovaries Syndrome1
2RecruitingTreatmentInsulin Resistance / Type 2 Diabetes Mellitus (T2D)1
2RecruitingTreatmentLung Cancers2
2RecruitingTreatmentLung Cancers / Non Small Cell Lung Cancer (NSCLC)1
2RecruitingTreatmentMelanoma1
2RecruitingTreatmentNonvalvular Atrial Fibrillation1
2RecruitingTreatmentPolycystic Kidney, Autosomal Dominant2
2RecruitingTreatmentPolycystic Ovarian Syndrome1
2RecruitingTreatmentProstatic Neoplasms1
2RecruitingTreatmentRectal Neoplasm Carcinoma in Situ Adenocarcinoma1
2RecruitingTreatmentRecurrent Prostate Carcinoma / Stage I Prostate Cancer / Stage IIA Prostate Cancer / Stage IIB Prostate Cancer / Stage III Prostate Cancer1
2RecruitingTreatmentRelapsed Chronic Lymphocytic Leukemia1
2RecruitingTreatmentStage IA Pancreatic Adenocarcinoma / Stage IB Pancreatic Adenocarcinoma / Stage IIA Pancreatic Adenocarcinoma / Stage IIB Pancreatic Adenocarcinoma1
2RecruitingTreatmentType 2 Diabetes Mellitus (T2D)1
2RecruitingTreatmentWell-differentiated Neuroendocrine Tumors1
2SuspendedTreatmentBMI >30 kg/m2 / Metabolic Syndromes1
2SuspendedTreatmentLarynx / LIP / Oral Cavity / Pharynx1
2TerminatedTreatmentCancer, Breast1
2TerminatedTreatmentCarcinoma of the Prostate1
2TerminatedTreatmentColorectal Cancers / Steatohepatitis1
2TerminatedTreatmentDiffuse Large B-Cell Lymphoma (DLBCL)1
2TerminatedTreatmentMetastatic Breast Cancer (MBC)1
2TerminatedTreatmentMetastatic Non-Small Cell Lung Cancer / Non-small Cell Lung Cancer Stage IIIB/IV / Nonsquamous Nonsmall Cell Neoplasm of Lung1
2TerminatedTreatmentNeoplasms, Colorectal1
2TerminatedTreatmentNon-Small-Cell Lung Carcinoma (NSCLC)1
2TerminatedTreatmentPancreatic Cancers1
2TerminatedTreatmentType 2 Diabetes Mellitus (T2D)8
2TerminatedTreatmentWeight gain therapy1
2Unknown StatusTreatmentBMI >30 kg/m21
2Unknown StatusTreatmentCancer, Breast1
2Unknown StatusTreatmentDiabetes, Gestational / Metformin / Oxidative Stress / Treatments1
2Unknown StatusTreatmentFamilial Adenomatous Polyposis (FAP)1
2Unknown StatusTreatmentIntrabony Defects in Chronic Periodontitis1
2Unknown StatusTreatmentLocally Advanced Malignant Neoplasm1
2Unknown StatusTreatmentMetabolic Syndromes1
2Unknown StatusTreatmentMetastatic Melanoma (Stage IIIC Non-résécable or no Surgically Curable or Stage IV With Classification AJCC)1
2Unknown StatusTreatmentNonalcoholic Fatty Liver Disease / Nonalcoholic Steatohepatitis1
2Unknown StatusTreatmentPre-Diabetes1
2Unknown StatusTreatmentPreviously Treated Advanced Colorectal Cancer1
2Unknown StatusTreatmentProstate Cancer Metastatic1
2Unknown StatusTreatmentType 2 Diabetes Mellitus (T2D)1
2WithdrawnNot AvailablePulmonary Arterial Hypertension (PAH)1
2WithdrawnTreatmentCarcinoma of the Prostate3
2WithdrawnTreatmentEndometrial Cancers1
2, 3CompletedPreventionBMI >30 kg/m2 / Complications, Pregnancy1
2, 3CompletedPreventionDiabetes / Glucose tolerance impaired / Inflammatory processes1
2, 3CompletedTreatmentBurns1
2, 3CompletedTreatmentChronic Periodontitis3
2, 3CompletedTreatmentDiabetes1
2, 3CompletedTreatmentGestational Diabetes Mellitus (GDM)1
2, 3CompletedTreatmentPeriodontitis1
2, 3CompletedTreatmentType 2 Diabetes Mellitus (T2D)5
2, 3Not Yet RecruitingHealth Services ResearchPolycystic Ovaries Syndrome1
2, 3Not Yet RecruitingTreatmentComplications, Pregnancy / Intrahepatic Cholestases1
2, 3Not Yet RecruitingTreatmentDiabetes Mellitus (DM) / Gastroduodenal Ulcers / Iron Metabolism Disorders / Optic Atrophy / Platelet Dysfunction / Sensorineural Hearing Loss1
2, 3RecruitingPreventionDiabetes, Gestational / Polycystic Ovaries Syndrome1
2, 3RecruitingTreatmentEndometrial Adenocarcinomas / Endometrial Clear Cell Adenocarcinoma / Endometrial Serous Adenocarcinoma / Endometrial Undifferentiated Carcinoma / Recurrent Uterine Corpus Carcinoma / Stage IIIA Uterine Corpus Cancer / Stage IIIB Uterine Corpus Cancer / Stage IIIC Uterine Corpus Cancer / Stage IVA Uterine Corpus Cancer / Stage IVB Uterine Corpus Cancer1
2, 3RecruitingTreatmentHyperglycemias / Hypermetabolism / Insulin Resistance1
2, 3RecruitingTreatmentType 2 Diabetes Mellitus (T2D)1
2, 3TerminatedTreatmentDyslipidemias / Type 2 Diabetes Mellitus (T2D)1
2, 3TerminatedTreatmentType 2 Diabetes Mellitus (T2D)1
2, 3Unknown StatusTreatmentBMI >30 kg/m21
2, 3Unknown StatusTreatmentChronic Hepatitis C Virus (HCV) Infection / Insulin Resistance1
2, 3Unknown StatusTreatmentCoronary Artery Disease / Diabetes / Heart Failure (HF) / ST Elevation Myocardial Infarction (STEMI)1
2, 3Unknown StatusTreatmentDiabetes, Gestational / Pregnancy / Type 2 Diabetes Mellitus (T2D)1
2, 3Unknown StatusTreatmentFatty Liver1
2, 3Unknown StatusTreatmentGlucocorticoid Treatment1
2, 3Unknown StatusTreatmentType 2 Diabetes Mellitus (T2D)1
3Active Not RecruitingTreatmentCancer, Breast1
3Active Not RecruitingTreatmentDiabetes, Diabetes Mellitus Type 11
3Active Not RecruitingTreatmentGynecology1
3Active Not RecruitingTreatmentPreDiabetes / Type 2 Diabetes Mellitus (T2D)1
3Active Not RecruitingTreatmentType 2 Diabetes Mellitus (T2D)8
3CompletedPreventionAtherosclerosis / Cardiovascular Disease (CVD) / Coronary Disease / Diabetes Mellitus (DM) / Hypercholesterolaemia / Hypertensive / Type 2 Diabetes Mellitus (T2D)1
3CompletedPreventionDiabetes / Impaired Glucose Tolerance (IGT)1
3CompletedPreventionPolycystic Ovaries Syndrome2
3CompletedPreventionSchizoaffective Disorders / Schizophrenia1
3CompletedTreatmentAnovulatory cycle / Hyperandrogenism / Infertilities / Oligoovulation / Polycystic Ovaries Syndrome1
3CompletedTreatmentAutism Spectrum Disorder (ASD) / BMI >27 kg/m21
3CompletedTreatmentBMI >30 kg/m21
3CompletedTreatmentBMI >30 kg/m2 / Diabetes1
3CompletedTreatmentBMI >30 kg/m2 / Hypogonadism1
3CompletedTreatmentBMI >30 kg/m2 / Insulin Resistance1
3CompletedTreatmentDiabetes3
3CompletedTreatmentDiabetes Mellitus (DM)10
3CompletedTreatmentDiabetes Mellitus (DM) / Dyslipidemias1
3CompletedTreatmentDiabetes Mellitus, Non-Insulin-Dependent1
3CompletedTreatmentDiabetes Mellitus, Non-Insulin-Dependent / Type 2 Diabetes Mellitus, Non Insulin Dependent1
3CompletedTreatmentDiabetes, Diabetes Mellitus Type 12
3CompletedTreatmentDiabetes, Gestational / Infertilities / Miscarriages / Polycystic Ovaries Syndrome / Toxemia1
3CompletedTreatmentDiabetes / Type 2 Diabetes Mellitus (T2D)13
3CompletedTreatmentDisorder of Glucose Regulation / Polycystic Ovaries Syndrome1
3CompletedTreatmentDuchenne's Muscular Dystrophy (DMD)1
3CompletedTreatmentDyslipidemia/Glucose Metabolism Disorder1
3CompletedTreatmentDyslipidemias / Type 2 Diabetes Mellitus (T2D)1
3CompletedTreatmentFatty Liver1
3CompletedTreatmentGestational Diabetes Mellitus (GDM)1
3CompletedTreatmentHypercholesterolaemia / Pre-Diabetes / Type 2 Diabetes Mellitus (T2D)1
3CompletedTreatmentInsulin Sensitivity / Polycystic Ovarian Syndrome1
3CompletedTreatmentMetabolic Syndromes2
3CompletedTreatmentNon-Insulin-Dependent Diabetes Mellitus1
3CompletedTreatmentNon-Insulin-Dependent Diabetes Mellitus / Type 2 Diabetes Mellitus (T2D)1
3CompletedTreatmentPolycystic Ovaries Syndrome6
3CompletedTreatmentPoor Glycemic Control1
3CompletedTreatmentType 2 Diabetes Mellitus (T2D)129
3Not Yet RecruitingHealth Services ResearchDiabetes Mellitus (DM)1
3Not Yet RecruitingPreventionCarcinoma of the Prostate / Metabolic Syndromes1
3Not Yet RecruitingPreventionNon-DM Stage III Colorectal Cancer1
3Not Yet RecruitingTreatmentDiabetes, Gestational1
3Not Yet RecruitingTreatmentDiabetes, Gestational / Insulin Resistance1
3Not Yet RecruitingTreatmentDiabetes / Pregnancy1
3Not Yet RecruitingTreatmentPsoriasis1
3Not Yet RecruitingTreatmentType 2 Diabetes Mellitus (T2D)3
3RecruitingPreventionAtypical Ductal Breast Hyperplasia / BRCA1 Mutation Carrier / BRCA2 Mutation Carrier / Ductal Breast Carcinoma In Situ / Lobular Breast Carcinoma In Situ1
3RecruitingPreventionGestational Diabetes Mellitus (GDM)1
3RecruitingPreventionMetabolic Syndromes1
3RecruitingTreatmentBMI >30 kg/m2 / Polycystic Ovaries Syndrome1
3RecruitingTreatmentBipolar Disorder (BD)1
3RecruitingTreatmentBrain Tumor Treated With Cranial or Cranial-Spinal Radiation1
3RecruitingTreatmentCarcinoma of the Prostate1
3RecruitingTreatmentDiabetes Mellitus (DM) / Type 2 Diabetes Mellitus (T2D)1
3RecruitingTreatmentDiabetes Prevention in Women After GDM Who Are at High-risk1
3RecruitingTreatmentDiabetes / Type 2 Diabetes Mellitus (T2D)1
3RecruitingTreatmentDyslipidemias / Type 2 Diabetes Mellitus (T2D)3
3RecruitingTreatmentInsulin Resistance / Polycystic Ovaries Syndrome1
3RecruitingTreatmentMigraines1
3RecruitingTreatmentPre-frail Elderly1
3RecruitingTreatmentPreDiabetes / Type 2 Diabetes Mellitus (T2D)1
3RecruitingTreatmentType 2 Diabetes Mellitus (T2D)11
3TerminatedNot AvailableCoronary and Peripheral Endothelial Dysfunction1
3TerminatedPreventionHepatitis C, Chronic / Hepatocellular Carcinomas / Liver Cirrhosis1
3TerminatedTreatmentCongestive Heart Failure (CHF) / Type 2 Diabetes Mellitus (T2D)1
3TerminatedTreatmentDiabetes Mellitus (DM)1
3TerminatedTreatmentDiabetes / Type 2 Diabetes Mellitus (T2D)3
3TerminatedTreatmentType 2 Diabetes Mellitus (T2D)10
3Unknown StatusEducational/Counseling/TrainingBMI >30 kg/m21
3Unknown StatusPreventionDiabetes Mellitus (DM)1
3Unknown StatusTreatmentBMI >30 kg/m21
3Unknown StatusTreatmentDiabetes, Diabetes Mellitus Type 11
3Unknown StatusTreatmentDiabetes, Gestational / Type 2 Diabetes Mellitus (T2D)1
3Unknown StatusTreatmentPlus Acarbose 50 mg Tablets) Thrice Daily Versus Acarbose 50 mg Thrice Daily Over 16 Weeks in / Subjects With Type 2 Diabetes Mellitus / The Objectives of the Study is to Evaluate the Efficacy and Safety of Acarmet (Metformin HCl 500 mg1
3Unknown StatusTreatmentType 2 Diabetes Mellitus (T2D)3
3WithdrawnTreatmentInsulin Resistance / Polycystic Ovaries Syndrome1
3WithdrawnTreatmentType 2 Diabetes Mellitus (T2D)1
4Active Not RecruitingBasic ScienceDyslipidemias / Type 2 Diabetes Mellitus (T2D)1
4Active Not RecruitingBasic ScienceHealthy Volunteers1
4Active Not RecruitingPreventionAging1
4Active Not RecruitingPreventionBMI >30 kg/m2 / Gonadal Dysfunction / Insulin Resistance / Type 2 Diabetes Mellitus (T2D)1
4Active Not RecruitingPreventionMountain Sickness1
4Active Not RecruitingTreatmentBMI >27 kg/m2 / BMI >30 kg/m2 / Masked Hypertension / Type 2 Diabetes Mellitus (T2D)1
4Active Not RecruitingTreatmentDiabetes1
4Active Not RecruitingTreatmentDiabetes, Diabetes Mellitus Type 11
4Active Not RecruitingTreatmentPolycystic Ovaries Syndrome1
4Active Not RecruitingTreatmentType 2 Diabetes Mellitus (T2D)3
4CompletedNot AvailableAmenorrhea1
4CompletedNot AvailableChronic Hepatitis C Infection1
4CompletedNot AvailableDiabetes1
4CompletedNot AvailableDiabetes Mellitus (DM)1
4CompletedNot AvailableOther Conditions That May Be A Focus of Clinical Attention2
4CompletedNot AvailableType 2 Diabetes Mellitus (T2D)2
4CompletedBasic ScienceDiabetes / Glucose Metabolism Disorders1
4CompletedBasic ScienceType 2 Diabetes Mellitus (T2D)2
4CompletedHealth Services ResearchMetformin / Organic Cation Transporter 2 / Single Nucleotide Polymorphisms1
4CompletedHealth Services ResearchPharmacogenetics of Metformin1
4CompletedPreventionBMI >30 kg/m2 / Type 2 Diabetes Mellitus (T2D)1
4CompletedPreventionCardiovascular Disease (CVD) / Ischemic Heart Diseases1
4CompletedPreventionDiabetes, Diabetes Mellitus Type 11
4CompletedPreventionLeft Ventriclar Mass1
4CompletedPreventionMetabolic Complications1
4CompletedPreventionPatients With Glucocorticoid Treatment1
4CompletedSupportive CareLiver Diseases1
4CompletedTreatmentAging / Inflammatory processes / Insulin Resistance / PreDiabetes1
4CompletedTreatmentAnovulatory cycle / Infertilities / Polycystic Ovaries Syndrome1
4CompletedTreatmentApoptotic Signal Pathways in Endometrial Hyperplasia1
4CompletedTreatmentArteriosclerosis / Atherosclerosis / Type 2 Diabetes Mellitus (T2D)1
4CompletedTreatmentAutism Spectrum Disorder (ASD) / Bipolar Disorder (BD) / Schizoaffective Disorders / Schizophrenia / Schizophreniform Disorder1
4CompletedTreatmentBMI >27 kg/m2 / BMI >30 kg/m2 / Type 2 Diabetes Mellitus (T2D)1
4CompletedTreatmentBMI >30 kg/m21
4CompletedTreatmentBMI >30 kg/m2 / Polycystic Ovarian Syndrome6
4CompletedTreatmentBMI >30 kg/m2 / Polycystic Ovaries Syndrome1
4CompletedTreatmentBipolar Disorder (BD)1
4CompletedTreatmentBody Weights / Insulin Resistance1
4CompletedTreatmentBody Weights / Polycystic Ovaries Syndrome1
4CompletedTreatmentChronic Hepatitis C Virus (HCV) Infection1
4CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)1
4CompletedTreatmentCongestive Heart Failure (CHF) / Insulin Resistance1
4CompletedTreatmentCoronary Artery Disease1
4CompletedTreatmentCoronary Artery Disease / Type 2 Diabetes Mellitus (T2D)2
4CompletedTreatmentDepression1
4CompletedTreatmentDiabetes2
4CompletedTreatmentDiabetes Ketoacidosis / Hyperglycemias / Ketosis Prone Diabetes1
4CompletedTreatmentDiabetes Mellitus (DM)3
4CompletedTreatmentDiabetes Mellitus (DM) / Endothelial Dysfunction1
4CompletedTreatmentDiabetes Mellitus, Non-Insulin-Dependent1
4CompletedTreatmentDiabetes, Diabetes Mellitus Type 11
4CompletedTreatmentDiabetes, Gestational2
4CompletedTreatmentDiabetes / Hypertensive1
4CompletedTreatmentDiabetes / Type 2 Diabetes Mellitus (T2D)17
4CompletedTreatmentDyslipidemias1
4CompletedTreatmentEndothelial Function / Ischemia Reperfusion Injury1
4CompletedTreatmentGestational Diabetes Mellitus (GDM)1
4CompletedTreatmentGlucotoxicity / Pancreatic Beta Cell Function / Type 2 Diabetes Mellitus (T2D)1
4CompletedTreatmentHepatitis C1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Lipodystrophies1
4CompletedTreatmentHyperinsulinemia / Insulin Resistance / Pediatric Obesity1
4CompletedTreatmentHypoglycemia / Type 2 Diabetes Mellitus (T2D)1
4CompletedTreatmentImpaired Glucose Tolerance (IGT)1
4CompletedTreatmentInfertilities / Polycystic Ovary Syndrome (PCOS)1
4CompletedTreatmentInsufficient Metabolic Control / OAD Treatment / Type 2 Diabetic Patients1
4CompletedTreatmentInsulin Resistance / Polycystic Ovaries Syndrome1
4CompletedTreatmentInsulin Sensitivity / Type 2 Diabetes Mellitus (T2D)1
4CompletedTreatmentIschemic Heart Diseases / Type 2 Diabetes Mellitus (T2D)1
4CompletedTreatmentMetabolic Syndromes1
4CompletedTreatmentNon-Alcoholic Fatty Liver Disease (NAFLD) / Type2 Diabetes1
4CompletedTreatmentNon-Insulin-Dependent Diabetes Mellitus1
4CompletedTreatmentPCO1
4CompletedTreatmentPediatric Obesity1
4CompletedTreatmentPolycystic Ovarian Syndrome1
4CompletedTreatmentPolycystic Ovaries Syndrome5
4CompletedTreatmentPsychotic Disorders1
4CompletedTreatmentSchizophrenia2
4CompletedTreatmentType 2 Diabetes Mellitus (T2D)55
4CompletedTreatmentWeight gain therapy1
4Enrolling by InvitationPreventionPrediabetic State1
4Enrolling by InvitationTreatmentType 2 Diabetes Mellitus (T2D)1
4Not Yet RecruitingNot AvailableDiabetes Mellitus (DM) / Hypoglycemic Episodes1
4Not Yet RecruitingBasic ScienceCarcinoma of the Prostate1
4Not Yet RecruitingPreventionHypertensive / Type 2 Diabetes Mellitus (T2D)1
4Not Yet RecruitingTreatmentAcanthosis Nigricans1
4Not Yet RecruitingTreatmentAtherosclerosis / Metformin / Prediabetic State1
4Not Yet RecruitingTreatmentBeta Thalassemia Major Anemia1
4Not Yet RecruitingTreatmentCoronary Endothelial Function1
4Not Yet RecruitingTreatmentDiabetes, Gestational / Pregnancy in Diabetes1
4Not Yet RecruitingTreatmentGestational Diabetes Mellitus, Class A21
4Not Yet RecruitingTreatmentHepatic Steatosis / HIV-1-infection1
4Not Yet RecruitingTreatmentInsulin Resistance1
4Not Yet RecruitingTreatmentType 2 Diabetes Mellitus (T2D)4
4RecruitingNot AvailableHeart Failure, Systolic1
4RecruitingBasic ScienceDepression / Insulin Resistance / Metabolic Syndromes1
4RecruitingBasic SciencePolycystic Ovaries Syndrome1
4RecruitingBasic ScienceTolerance1
4RecruitingHealth Services ResearchCoronary Artery Disease / Hypertensive / Mild Cognitive Impairment (MCI) / Obesity, Abdominal1
4RecruitingPreventionGestational Diabetes Mellitus (GDM)1
4RecruitingPreventionInsulin Resistance1
4RecruitingPreventionInsulin Resistance / Prediabetic State1
4RecruitingPreventionPreDiabetes1
4RecruitingSupportive CareAcromegaly / Cushing's Disease1
4RecruitingTreatmentAtaxia-Telangiectasia1
4RecruitingTreatmentAtherosclerosis / Coronary Artery Disease / Prediabetic State1
4RecruitingTreatmentAtherosclerosis / Diabetes / Restenosis1
4RecruitingTreatmentBMI >27 kg/m2 / Schizoaffective Disorders / Schizophrenia1
4RecruitingTreatmentBipolar Disorder (BD)1
4RecruitingTreatmentDiabetes, Diabetes Mellitus Type 11
4RecruitingTreatmentDiabetes / Type 2 Diabetes Mellitus (T2D)1
4RecruitingTreatmentDisorder of Glucose Regulation1
4RecruitingTreatmentEndothelial Function / Type 2 Diabetes Mellitus (T2D)1
4RecruitingTreatmentGLP-1;Telomere-telomerase System; Par-4 / GLP-1;Metformin;Telomere-telomerase System;Par-41
4RecruitingTreatmentHepatic Encephalopathy / Liver Cirrhosis1
4RecruitingTreatmentHypertensive1
4RecruitingTreatmentImpaired Fasting Glucose (IFG) / Impaired Glucose Tolerance (IGT) / PreDiabetes1
4RecruitingTreatmentInfertilities1
4RecruitingTreatmentInsulin Resistance / Mild Cognitive Impairment (MCI) / Type 2 Diabetes Mellitus (T2D)1
4RecruitingTreatmentMetabolic Syndromes / Non-Alcoholic Fatty Liver Disease (NAFLD) / Polycystic Ovaries Syndrome1
4RecruitingTreatmentPeripheral Artery Disease (PAD)1
4RecruitingTreatmentPolycystic Ovaries Syndrome1
4RecruitingTreatmentSchizophrenia1
4RecruitingTreatmentSchizophrenia / Type 2 Diabetes Mellitus (T2D)1
4RecruitingTreatmentSystemic Lupus Erythematosus (SLE)1
4RecruitingTreatmentType 2 Diabetes Mellitus (T2D)11
4TerminatedNot AvailableSchizo-Affective Disorder / Schizophrenia1
4TerminatedPreventionInsulin Sensitivity / Polycystic Ovarian Syndrome / Polycystic Ovaries Syndrome1
4TerminatedTreatmentCoronary Artery Disease1
4TerminatedTreatmentDiabetes / Type 2 Diabetes Mellitus (T2D)1
4TerminatedTreatmentFatty Liver1
4TerminatedTreatmentInfertilities / Polycystic Ovarian Syndrome / Prognosis for Poor Response1
4TerminatedTreatmentIntermittent Claudication / Peripheral Arterial Disease (PAD)1
4TerminatedTreatmentType 2 Diabetes Mellitus (T2D)3
4Unknown StatusPreventionBMI >30 kg/m2 / Diabetes, Gestational / Polycystic Ovaries Syndrome1
4Unknown StatusPreventionType 2 Diabetes Mellitus (T2D)1
4Unknown StatusTreatmentAbortion, Habitual1
4Unknown StatusTreatmentBMI >30 kg/m21
4Unknown StatusTreatmentChronic Hepatitis C Virus (HCV) Infection1
4Unknown StatusTreatmentChronic Hepatitis C Virus (HCV) Infection / Insulin Resistance1
4Unknown StatusTreatmentCoronary Artery Disease / Type 2 Diabetes Mellitus (T2D)1
4Unknown StatusTreatmentDiabetes, Diabetes Mellitus Type 11
4Unknown StatusTreatmentDiabetes, Gestational1
4Unknown StatusTreatmentDiabetic Blood Glucose Monitoring / Exercise / Hypoglycemic Agents / Type 2 Diabetes Mellitus (T2D)1
4Unknown StatusTreatmentDrug Induced Weight Gain1
4Unknown StatusTreatmentMetabolic Syndromes1
4Unknown StatusTreatmentPolycystic Ovarian Syndrome1
4Unknown StatusTreatmentPolycystic Ovaries Syndrome2
4Unknown StatusTreatmentPreDiabetes1
4Unknown StatusTreatmentSevere Hyperglycemia - Blood Glucose Level >300mg/dl / Type 2 Diabetes Mellitus (T2D)1
4Unknown StatusTreatmentType 2 Diabetes Mellitus (T2D)6
4WithdrawnNot AvailableType 2 Diabetes Mellitus (T2D)1
4WithdrawnBasic ScienceType 2 Diabetes Mellitus (T2D)1
4WithdrawnPreventionSchizoaffective Disorders / Schizophrenia1
4WithdrawnTreatmentBMI >30 kg/m2 / Insulin Resistance1
4WithdrawnTreatmentPolycystic Ovaries Syndrome1
4WithdrawnTreatmentType 2 Diabetes Mellitus (T2D)3
Not AvailableActive Not RecruitingNot AvailableCancer, Breast / Depression / Lethargy / Sleep disorders and disturbances1
Not AvailableActive Not RecruitingBasic ScienceAcute Lymphoblastic Leukaemias (ALL)1
Not AvailableActive Not RecruitingBasic ScienceBMI >30 kg/m2 / PreDiabetes / Type 2 Diabetes Mellitus (T2D)1
Not AvailableActive Not RecruitingBasic ScienceHyperandrogenism / Polycystic Ovaries Syndrome1
Not AvailableActive Not RecruitingBasic SciencePolycystic Ovaries Syndrome1
Not AvailableActive Not RecruitingPreventionBMI >30 kg/m2 / Cancer, Breast1
Not AvailableActive Not RecruitingPreventionNeoplasms, Breast1
Not AvailableActive Not RecruitingTreatmentDiabetes1
Not AvailableActive Not RecruitingTreatmentEndometrial Cancers1
Not AvailableActive Not RecruitingTreatmentNeoplasms, Breast / Stage 0 Breast Carcinoma / Stage I Breast Carcinoma / Stage II Breast Carcinoma / Stage III Breast Carcinoma1
Not AvailableActive Not RecruitingTreatmentPolycystic Ovaries Syndrome1
Not AvailableCompletedNot AvailableAcanthosis Nigricans / Hyperinsulinemia / Spectroscopic Analysis1
Not AvailableCompletedNot AvailableCarcinoma of the Prostate1
Not AvailableCompletedNot AvailableCarotid Atherosclerosis / Metabolic Syndromes / Stroke / Type 2 Diabetes Mellitus (T2D)1
Not AvailableCompletedNot AvailableDiabetes Mellitus, Type 2 AND Metformin1
Not AvailableCompletedNot AvailableDiabetes / Type 2 Diabetes Mellitus (T2D)1
Not AvailableCompletedNot AvailableEndocrine System Diseases1
Not AvailableCompletedNot AvailableHealthy Volunteers3
Not AvailableCompletedNot AvailablePolycystic Ovarian Syndrome1
Not AvailableCompletedNot AvailablePolycystic Ovary Syndrom / Pregestational Diabetes / Pregnancy1
Not AvailableCompletedNot AvailableType 2 Diabetes Mellitus (T2D)8
Not AvailableCompletedBasic ScienceHealthy Adults1
Not AvailableCompletedBasic ScienceHealthy Overweight Obese1
Not AvailableCompletedBasic ScienceInsulin Resistance / Prediabetic State1
Not AvailableCompletedBasic ScienceTo Assess the Impact of Bile Acids on Human Glukagon-like-peptide-1 Secretion1
Not AvailableCompletedBasic ScienceType 2 Diabetes Mellitus (T2D)6
Not AvailableCompletedDiagnosticBMI >30 kg/m21
Not AvailableCompletedDiagnosticOther Conditions That May Be A Focus of Clinical Attention1
Not AvailableCompletedPreventionAcidosis, Respiratory / Diabetes Mellitus (DM)1
Not AvailableCompletedSupportive CareDiabetes1
Not AvailableCompletedTreatmentBMI >30 kg/m22
Not AvailableCompletedTreatmentBMI >30 kg/m2 / Insulin Resistance / Insulin Sensitivity1
Not AvailableCompletedTreatmentBMI >30 kg/m2 / Pre-Diabetes1
Not AvailableCompletedTreatmentBMI >30 kg/m2 / Type 2 Diabetes Mellitus (T2D)1
Not AvailableCompletedTreatmentCancer, Breast1
Not AvailableCompletedTreatmentDiabetes1
Not AvailableCompletedTreatmentDiabetes Mellitus (DM) / Hypertension, Essential1
Not AvailableCompletedTreatmentDiabetes Mellitus, Non-Insulin-Dependent1
Not AvailableCompletedTreatmentDiabetes, Gestational1
Not AvailableCompletedTreatmentDiabetes, Gestational / Insulin Resistance1
Not AvailableCompletedTreatmentDiabetes / Heart Failure (HF)2
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Hyperinsulinemia / Lipodystrophies1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Metabolic Syndromes1
Not AvailableCompletedTreatmentHyperinsulinism / Polycystic Ovaries Syndrome2
Not AvailableCompletedTreatmentInsulin Resistance1
Not AvailableCompletedTreatmentInsulin Resistance / Polycystic Ovaries Syndrome1
Not AvailableCompletedTreatmentMalignant Neoplasm of Thyroid Stage I / Malignant Neoplasm of Thyroid Stage II1
Not AvailableCompletedTreatmentNASH Related Cirrhosis1
Not AvailableCompletedTreatmentNeuromuscular Diseases / Spina Bifida1
Not AvailableCompletedTreatmentPolycystic Ovaries Syndrome10
Not AvailableCompletedTreatmentPsoriatic Arthritis1
Not AvailableCompletedTreatmentType 2 Diabetes Mellitus (T2D)7
Not AvailableEnrolling by InvitationNot AvailableDiabetes, Gestational1
Not AvailableNot Yet RecruitingNot AvailableType 2 Diabetes Mellitus (T2D)2
Not AvailableNot Yet RecruitingTreatmentHuman Immunodeficiency Virus (HIV) / Hypertensive / Type 2 Diabetes Mellitus (T2D)1
Not AvailableNot Yet RecruitingTreatmentPeripheral Artery Disease (PAD)1
Not AvailableNot Yet RecruitingTreatmentPolycystic Ovaries Syndrome1
Not AvailableNot Yet RecruitingTreatmentSmall for Gestational Age1
Not AvailableNot Yet RecruitingTreatmentType 2 Diabetes Mellitus (T2D)2
Not AvailableRecruitingBasic ScienceBMI >30 kg/m2 / Hyperandrogenemia / Polycystic Ovaries Syndrome1
Not AvailableRecruitingBasic ScienceType 2 Diabetes Mellitus (T2D)1
Not AvailableRecruitingOtherEGFR Gene Mutation / Non-Small Cell Adenocarcinoma / Tyrosine kinase mutation1
Not AvailableRecruitingPreventionCoronary Heart Disease (CHD)1
Not AvailableRecruitingPreventionPolycystic Ovaries Syndrome / Pregnancy1
Not AvailableRecruitingSupportive CareAging1
Not AvailableRecruitingSupportive CareType 2 Diabetes Mellitus (T2D)1
Not AvailableRecruitingTreatmentAnemias / Fevers / Lethargy / Lymphadenopathy / Lymphocytosis / Night Sweats / Recurrent Chronic Lymphocytic Leukemia / Recurrent Plasma Cell Myeloma / Refractory Chronic Lymphocytic Leukemia / Refractory Plasma Cell Myeloma / Splenomegaly / Thrombocytopenias / Weight Loss1
Not AvailableRecruitingTreatmentBMI >30 kg/m2 / Polycystic Ovaries Syndrome1
Not AvailableRecruitingTreatmentBurns1
Not AvailableRecruitingTreatmentComplex Atypical Hyperplasia / Endometrial Cancers1
Not AvailableRecruitingTreatmentCoronary Artery Disease / Diabetes Mellitus (DM) / Type 2 Diabetes Mellitus (T2D)1
Not AvailableRecruitingTreatmentDiabetes2
Not AvailableRecruitingTreatmentDiabetes, Gestational1
Not AvailableRecruitingTreatmentGenetics / Metabolism / Type 2 Diabetes Mellitus (T2D)1
Not AvailableRecruitingTreatmentImpaired Fasting Glucose (IFG) / Impaired Glucose Tolerance (IGT) / Type 2 Diabetes Mellitus (T2D)1
Not AvailableRecruitingTreatmentInsulin Resistance / Major Lung or Abdominal Surgery / Pre-Diabetes1
Not AvailableRecruitingTreatmentInsulin Sensitivity / Metabolic Syndromes / Vascular Function1
Not AvailableRecruitingTreatmentMild Graves' Ophthalmopathy1
Not AvailableRecruitingTreatmentPolycystic Ovaries Syndrome3
Not AvailableRecruitingTreatmentType 2 Diabetes Mellitus (T2D)1
Not AvailableTerminatedNot AvailableType 2 Diabetes Mellitus (T2D)1
Not AvailableTerminatedBasic SciencePolycystic Ovaries Syndrome1
Not AvailableTerminatedDiagnosticBMI >30 kg/m2 / Diabetes / Pre-Diabetes1
Not AvailableTerminatedDiagnosticType 2 Diabetes Mellitus (T2D)1
Not AvailableTerminatedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Diabetes Mellitus (DM) / Hyperglycemias / Insulin Resistance1
Not AvailableTerminatedTreatmentBMI >30 kg/m2 / Schizophrenia1
Not AvailableTerminatedTreatmentCancer, Breast1
Not AvailableTerminatedTreatmentCarcinoma of the Prostate1
Not AvailableTerminatedTreatmentMetabolic Syndromes1
Not AvailableTerminatedTreatmentPremature Pubarche1
Not AvailableUnknown StatusNot AvailableArterial Hypertension / Diabetes Mellitus (DM)1
Not AvailableUnknown StatusNot AvailableCancer, Breast1
Not AvailableUnknown StatusNot AvailableNutritional and Metabolic Diseases1
Not AvailableUnknown StatusNot AvailableType 2 Diabetes Mellitus (T2D)2
Not AvailableUnknown StatusBasic SciencePolycystic Ovaries Syndrome1
Not AvailableUnknown StatusPreventionPre-Diabetes / Pre-Hypertension1
Not AvailableUnknown StatusTreatmentBMI >30 kg/m2 / Metabolic Syndromes / Schizophrenia1
Not AvailableUnknown StatusTreatmentCardiovascular Disease (CVD)1
Not AvailableUnknown StatusTreatmentComplications, Pregnancy1
Not AvailableUnknown StatusTreatmentDiabetes, Gestational / Pregnancy / Type 2 Diabetes Mellitus (T2D)1
Not AvailableUnknown StatusTreatmentEndothelial Dysfunction / Polycystic Ovaries Syndrome1
Not AvailableUnknown StatusTreatmentLiver Diseases1
Not AvailableUnknown StatusTreatmentNonalcoholic Fatty Liver Disease (NAFLD)1
Not AvailableUnknown StatusTreatmentPolycystic Ovaries Syndrome5
Not AvailableUnknown StatusTreatmentType 2 Diabetes Mellitus (T2D)4
Not AvailableUnknown StatusTreatmentType 2 Diabetes Mellitus ;Obesity,High Triglycerides;TCM1
Not AvailableWithdrawnNot AvailableDiabetes Mellitus (DM)1
Not AvailableWithdrawnNot AvailableType 2 Diabetes Mellitus (T2D)1
Not AvailableWithdrawnPreventionAmenorrhea / Weight gain therapy1
Not AvailableWithdrawnPreventionGestational Diabetes Mellitus (GDM)1
Not AvailableWithdrawnTreatmentBMI >30 kg/m2 / Hypercholesterolaemia / Hypertensive / Insulin Resistance / Metabolic Syndromes1
Not AvailableWithdrawnTreatmentColorectum1
Not AvailableWithdrawnTreatmentType 2 Diabetes Mellitus (T2D)1
Pharmacoeconomics
Manufacturers
  • Ranbaxy pharmaceuticals inc
  • Andrx labs llc
  • Bristol myers squibb co
  • Depomed inc
  • Actavis elizabeth llc
  • Amneal pharmaceuticals ny llc
  • Apotex inc etobicoke site
  • Barr laboratories inc
  • Impax laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Neurosci inc
  • Nostrum pharmaceuticals inc
  • Ranbaxy laboratories ltd
  • Sandoz inc
  • Sun pharmaceutical industries ltd
  • Teva pharmaceuticals usa inc
  • Torrent pharma inc
  • Torrent pharmaceuticals ltd
  • Watson laboratories inc
  • Watson laboratories inc florida
  • Zydus pharmaceuticals usa inc
  • Bristol myers squibb co pharmaceutical research institute
  • Alphapharm party ltd
  • Alvogen inc
  • Apotex inc
  • Aurobindo pharma ltd
  • Caraco pharmaceutical laboratories ltd
  • Dr reddys laboratories inc
  • Genpharm inc
  • Glenmark generics ltd
  • Granules india ltd
  • Indicus pharma llc
  • Ipca laboratories ltd
  • Mutual pharmacal co
  • Provident pharmaceutical inc
  • Watson laboratories
Packagers
Dosage forms
FormRouteStrength
Kit
Kit
Tablet, extended releaseOral1000 mg/1
TabletOral1000 mg
TabletOral850 mg
Tablet, extended releaseOral500 mg/1
Tablet, extended releaseOral750 mg/1
Tablet, film coatedOral
Tablet, extended releaseOral1000 mg
Tablet, extended releaseOral500 mg
Tablet, film coated, extended releaseOral1000 mg/1
Tablet, film coated, extended releaseOral500 mg/1
TabletOral
Tablet, extended releaseOral
Tablet, film coated, extended releaseOral
TabletOral1000 mg/1
TabletOral500 mg/1
TabletOral850 mg/1
Tablet, film coatedOral1000 mg/1
Tablet, film coatedOral500 mg/1
Tablet, film coatedOral850 mg/1
TabletOral750 mg/1
Tablet, film coatedOral750 mg/1
SolutionOral500 mg/5mL
TabletOral500 mg
Prices
Unit descriptionCostUnit
Fortamet er 1000 mg tablet6.93USD tablet
Fortamet 1000 mg 24 Hour tablet6.01USD tablet
Fortamet 500 mg 24 Hour tablet2.55USD tablet
Fortamet er 500 mg tablet2.48USD tablet
Glucophage 1000 mg tablet2.33USD tablet
Metformin hcl crystals2.14USD g
Glucophage 850 mg tablet1.94USD tablet
Glucophage XR 750 mg 24 Hour tablet1.8USD tablet
Glucophage xr 750 mg tablet1.71USD tablet
Metformin hcl 1000 mg tablet1.48USD tablet
MetFORMIN HCl 750 mg 24 Hour tablet1.25USD tablet
Metformin hcl 850 mg tablet1.22USD tablet
Glucophage XR 500 mg 24 Hour tablet1.17USD tablet
Glucophage 500 mg tablet1.14USD tablet
Glucophage xr 500 mg tablet1.14USD tablet
Glucophage xr 500 mg tablet sa1.11USD tablet
MetFORMIN HCl 500 mg 24 Hour tablet0.75USD tablet
Metformin hcl 500 mg tablet0.72USD tablet
Glucophage 850 mg Tablet0.38USD tablet
Glucophage 500 mg Tablet0.3USD tablet
Riomet 500 mg/5 ml solution0.27USD ml
Riomet 500 mg/5ml Solution0.27USD ml
Apo-Metformin 850 mg Tablet0.21USD tablet
Co Metformin 850 mg Tablet0.21USD tablet
Mylan-Metformin 850 mg Tablet0.21USD tablet
Novo-Metformin 850 mg Tablet0.21USD tablet
Nu-Metformin 850 mg Tablet0.21USD tablet
Pms-Metformin 850 mg Tablet0.21USD tablet
Ratio-Metformin Hydrochloride 850 mg Tablet0.21USD tablet
Sandoz Metformin Fc 850 mg Tablet0.21USD tablet
Pms-Metformin 500 mg Tablet0.13USD tablet
Ran-Metformin 500 mg Tablet0.13USD tablet
Ratio-Metformin Hydrochloride 500 mg Tablet0.13USD tablet
Sandoz Metformin Fc 500 mg Tablet0.13USD tablet
Zym-Metformin 500 mg Tablet0.13USD tablet
Apo-Metformin 500 mg Tablet0.13USD tablet
Co Metformin 500 mg Tablet0.13USD tablet
Mylan-Metformin 500 mg Tablet0.13USD tablet
Novo-Metformin 500 mg Tablet0.13USD tablet
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Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2412671 No2006-10-032021-02-26Canada
CA2476496 No2009-12-152023-02-21Canada
US5965584 No1996-06-192016-06-19Us
US6099859 No1998-03-202018-03-20Us
US6150383 No1996-06-192016-06-19Us
US6150384 No1996-06-192016-06-19Us
US6166042 No1996-06-192016-06-19Us
US6166043 No1996-06-192016-06-19Us
US6172090 No1996-06-192016-06-19Us
US6211205 No1996-06-192016-06-19Us
US6288095 Yes1997-08-112017-08-11Us
US6303146 Yes2000-01-142020-01-14Us
US6303640 No1996-08-092016-08-09Us
US6303661 No1997-04-242017-04-24Us
US6329404 No1996-06-192016-06-19Us
US6340475 No1996-09-192016-09-19Us
US6414126 No2000-10-042020-10-04Us
US6475521 No1998-03-192018-03-19Us
US6488962 No2000-06-202020-06-20Us
US6495162 No1998-03-202018-03-20Us
US6515117 No2000-10-042020-10-04Us
US6635280 No1996-09-192016-09-19Us
US6660300 No1998-03-192018-03-19Us
US6699871 No2002-07-262022-07-26Us
US6723340 No2001-10-252021-10-25Us
US6790459 No2001-03-172021-03-17Us
US6866866 No2001-03-172021-03-17Us
US6890898 No1999-02-022019-02-02Us
US6890957 No2003-09-142023-09-14Us
US6936590 No2000-10-042020-10-04Us
US7078381 No1999-02-022019-02-02Us
US7125873 No2002-07-262022-07-26Us
US7326708 No2006-04-112026-04-11Us
US7358366 Yes2000-10-192020-10-19Us
US7407955 No2003-08-122023-08-12Us
US7459428 No1999-02-022019-02-02Us
US7579449 No2005-11-052025-11-05Us
US7713938 No2007-04-152027-04-15Us
US7780987 No2005-03-232025-03-23Us
US7785627 No2006-07-312026-07-31Us
US7807689 No2008-06-272028-06-27Us
US7919116 No1998-03-202018-03-20Us
US7919598 No2009-12-162029-12-16Us
US7943582 No2009-02-262029-02-26Us
US7943788 No2007-07-142027-07-14Us
US7959946 No2006-07-312026-07-31Us
US8119648 No2003-08-122023-08-12Us
US8173663 No2005-03-152025-03-15Us
US8178541 No2003-08-122023-08-12Us
US8222219 No2004-07-302024-07-30Us
US8236345 No2002-10-072022-10-07Us
US8288539 No2005-03-152025-03-15Us
US8323692 No2005-03-232025-03-23Us
US8414921 No2008-07-212028-07-21Us
US8470368 No2003-09-192023-09-19Us
US8475841 No1998-03-202018-03-20Us
US8501698 No2007-06-202027-06-20Us
US8513202 No2007-12-032027-12-03Us
US8628799 No2005-07-132025-07-13Us
US8668931 No2003-09-192023-09-19Us
US8673927 No2007-05-042027-05-04Us
US8685934 No2010-05-262030-05-26Us
US8785403 No2004-07-302024-07-30Us
US8846695 No2010-06-042030-06-04Us
US8883805 No2005-11-262025-11-26Us
US8900638 No2009-05-242029-05-24Us
US9060941 No2003-09-192023-09-19Us
US9101660 No2007-01-222027-01-22Us
US9155705 No2010-05-212030-05-21Us
US9173859 No2007-05-042027-05-04Us
US9198925 No2000-10-042020-10-04Us
USRE44186 No2003-07-312023-07-31Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point (°C)223-226 °CNot Available
water solubilityFreely soluble as HCl saltNot Available
logP-0.5Not Available
pKa12.4Not Available
Predicted Properties
PropertyValueSource
Water Solubility1.38 mg/mLALOGPS
logP-1.8ALOGPS
logP-0.92ChemAxon
logS-2ALOGPS
pKa (Strongest Basic)12.33ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area88.99 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity56.64 m3·mol-1ChemAxon
Polarizability13.43 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9156
Blood Brain Barrier+0.5868
Caco-2 permeable-0.8958
P-glycoprotein substrateNon-substrate0.6643
P-glycoprotein inhibitor INon-inhibitor0.9613
P-glycoprotein inhibitor IINon-inhibitor0.8892
Renal organic cation transporterNon-inhibitor0.7518
CYP450 2C9 substrateNon-substrate0.7929
CYP450 2D6 substrateNon-substrate0.7325
CYP450 3A4 substrateNon-substrate0.6906
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9159
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.913
CYP450 3A4 inhibitorNon-inhibitor0.9506
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9763
Ames testNon AMES toxic0.7367
CarcinogenicityNon-carcinogens0.6691
BiodegradationNot ready biodegradable0.938
Rat acute toxicity1.7407 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9807
hERG inhibition (predictor II)Non-inhibitor0.9274
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-001i-0900000000-9046e2aa0408a0396007View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-01qi-9700000000-a6b98d87cc840a082179View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-00dr-9000000000-8e80f301bad045540477View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positivesplash10-001i-0900000000-bd8aed328c944acd1270View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positivesplash10-03l9-9300000000-3d585674ffe84238e5bfView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positivesplash10-00di-9000000000-ee68820579ebe4d31082View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positivesplash10-00di-9000000000-4312e7e5e1b0dd9ef936View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positivesplash10-00di-9000000000-053d63fe09a95fc1d544View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-0229-9100000000-7fe999a9d1aaae3bbe53View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-001i-0900000000-c235cd5d0dda3f3c28d9View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-001i-0900000000-0fa445716bfc24131a75View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-001i-3900000000-dee37da326e6f0b2c56aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-001i-0900000000-45bd1f8c6d2dc4f38944View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-001i-1900000000-38f3dedb5c19900cdefbView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-001i-7900000000-bf5d1092aa372c303d61View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-03l9-9300000000-06a99f0dff4b41a23cfaView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-022i-9100000000-811c9e7cf8b30b27c0f2View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-00di-9000000000-d34b9b3ab9eb78317ebaView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-001i-0900000000-4d53ac0f7dfaf860e784View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-001i-1900000000-4b3dd439b62cfa2341b0View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-001i-6900000000-c595d8e83955ee66df73View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-03l9-9300000000-1feb1004b70a7c1f7679View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-022i-9100000000-588dd4672e983d25189bView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-00di-9000000000-fdc1342fbdd0301080c8View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-001i-3900000000-f3959910a3d1ce1d1379View in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as biguanides. These are organic compounds containing two N-linked guanidines.
KingdomOrganic compounds
Super ClassOrganic nitrogen compounds
ClassOrganonitrogen compounds
Sub ClassGuanidines
Direct ParentBiguanides
Alternative Parents
Substituents
  • Biguanide
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Carboximidamide
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Imine
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inducer
General Function:
Protein kinase activity
Specific Function:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK a...
Gene Name:
PRKAB1
Uniprot ID:
Q9Y478
Molecular Weight:
30382.085 Da
References
  1. Kovacic S, Soltys CL, Barr AJ, Shiojima I, Walsh K, Dyck JR: Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. J Biol Chem. 2003 Oct 10;278(41):39422-7. Epub 2003 Jul 29. [PubMed:12890675 ]
  2. Hardie DG: Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology. 2003 Dec;144(12):5179-83. Epub 2003 Sep 4. [PubMed:12960015 ]
  3. Ruderman NB, Saha AK, Kraegen EW: Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity. Endocrinology. 2003 Dec;144(12):5166-71. Epub 2003 Sep 18. [PubMed:14500570 ]
  4. Leverve XM, Guigas B, Detaille D, Batandier C, Koceir EA, Chauvin C, Fontaine E, Wiernsperger NF: Mitochondrial metabolism and type-2 diabetes: a specific target of metformin. Diabetes Metab. 2003 Sep;29(4 Pt 2):6S88-94. [PubMed:14502105 ]
  5. Leclerc I, Woltersdorf WW, da Silva Xavier G, Rowe RL, Cross SE, Korbutt GS, Rajotte RV, Smith R, Rutter GA: Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E1023-31. Epub 2004 Feb 10. [PubMed:14871885 ]
  6. Vucicevic L, Misirkic M, Janjetovic K, Harhaji-Trajkovic L, Prica M, Stevanovic D, Isenovic E, Sudar E, Sumarac-Dumanovic M, Micic D, Trajkovic V: AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C. Biochem Pharmacol. 2009 Jun 1;77(11):1684-93. doi: 10.1016/j.bcp.2009.03.005. Epub 2009 Mar 14. [PubMed:19428322 ]
  7. Towler MC, Hardie DG: AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res. 2007 Feb 16;100(3):328-41. [PubMed:17307971 ]
  8. Musi N, Hirshman MF, Nygren J, Svanfeldt M, Bavenholm P, Rooyackers O, Zhou G, Williamson JM, Ljunqvist O, Efendic S, Moller DE, Thorell A, Goodyear LJ: Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Diabetes. 2002 Jul;51(7):2074-81. [PubMed:12086935 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular Weight:
61153.345 Da
References
  1. Dresser MJ, Xiao G, Leabman MK, Gray AT, Giacomini KM: Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2). Pharm Res. 2002 Aug;19(8):1244-7. [PubMed:12240953 ]
  2. Wang DS, Jonker JW, Kato Y, Kusuhara H, Schinkel AH, Sugiyama Y: Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. J Pharmacol Exp Ther. 2002 Aug;302(2):510-5. [PubMed:12130709 ]
  3. Zolk O: Current understanding of the pharmacogenomics of metformin. Clin Pharmacol Ther. 2009 Dec;86(6):595-8. doi: 10.1038/clpt.2009.144. [PubMed:19915604 ]
  4. Tzvetkov MV, Vormfelde SV, Balen D, Meineke I, Schmidt T, Sehrt D, Sabolic I, Koepsell H, Brockmoller J: The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Clin Pharmacol Ther. 2009 Sep;86(3):299-306. doi: 10.1038/clpt.2009.92. Epub 2009 Jun 17. [PubMed:19536068 ]
  5. Ahlin G, Karlsson J, Pedersen JM, Gustavsson L, Larsson R, Matsson P, Norinder U, Bergstrom CA, Artursson P: Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. J Med Chem. 2008 Oct 9;51(19):5932-42. doi: 10.1021/jm8003152. Epub 2008 Sep 13. [PubMed:18788725 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Quaternary ammonium group transmembrane transporter activity
Specific Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:
SLC22A2
Uniprot ID:
O15244
Molecular Weight:
62579.99 Da
References
  1. Dresser MJ, Xiao G, Leabman MK, Gray AT, Giacomini KM: Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2). Pharm Res. 2002 Aug;19(8):1244-7. [PubMed:12240953 ]
  2. Zolk O: Current understanding of the pharmacogenomics of metformin. Clin Pharmacol Ther. 2009 Dec;86(6):595-8. doi: 10.1038/clpt.2009.144. [PubMed:19915604 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
  4. Kimura N, Masuda S, Tanihara Y, Ueo H, Okuda M, Katsura T, Inui K: Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet. 2005 Oct;20(5):379-86. [PubMed:16272756 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Toxin transporter activity
Specific Function:
Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.
Gene Name:
SLC22A3
Uniprot ID:
O75751
Molecular Weight:
61279.485 Da
References
  1. Muller J, Lips KS, Metzner L, Neubert RH, Koepsell H, Brandsch M: Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Biochem Pharmacol. 2005 Dec 5;70(12):1851-60. Epub 2005 Nov 2. [PubMed:16263091 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Monovalent cation:proton antiporter activity
Specific Function:
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport...
Gene Name:
SLC47A1
Uniprot ID:
Q96FL8
Molecular Weight:
61921.585 Da
References
  1. Meyer zu Schwabedissen HE, Verstuyft C, Kroemer HK, Becquemont L, Kim RB: Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. Am J Physiol Renal Physiol. 2010 Apr;298(4):F997-F1005. doi: 10.1152/ajprenal.00431.2009. Epub 2010 Jan 6. [PubMed:20053795 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Nucleoside transmembrane transporter activity
Specific Function:
Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cat...
Gene Name:
SLC29A4
Uniprot ID:
Q7RTT9
Molecular Weight:
58058.005 Da
References
  1. Zhou M, Xia L, Wang J: Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine. Drug Metab Dispos. 2007 Oct;35(10):1956-62. Epub 2007 Jun 28. [PubMed:17600084 ]
Drug created on June 13, 2005 07:24 / Updated on May 28, 2017 07:42