Displaying drugs 3676 - 3700 of 8028 in total
Mirococept
Mirococept (APT070) is a complement inhibitor currently under development for treatment of rheumatoid arthritis and I/RI. It is a truncated form of the human Complement Receptor 1 (CR1) linked to a unique Prodaptin™ construct that regulates the over-production of complement at the cell surface, which occurs in inflammation. It consists...
Investigational
Matched Synonyms: … myristoylated recombinant SCR1-3 of human complement reseptor type I …
Matched Description: … It consists of the first three short consensus domains of human complement receptor 1 (CR1), manufactured ... Mirococept (APT070) is a complement inhibitor currently under development for treatment of rheumatoid ... It is a truncated form of the human Complement Receptor 1 (CR1) linked to a unique Prodaptin™ construct …
Matched Description: … It consists of the first three short consensus domains of human complement receptor 1 (CR1), manufactured ... Mirococept (APT070) is a complement inhibitor currently under development for treatment of rheumatoid ... It is a truncated form of the human Complement Receptor 1 (CR1) linked to a unique Prodaptin™ construct …
West Nile immune globulin
Investigational
Matched Synonyms: … Immune Globulin (Human) containing high titers of West Nile virus antibodies …
Ginsenosides
Dammarane type triterpene saponins based mainly on the aglycones, protopanaxadiol and protopanaxatriol.
Experimental
Matched Synonyms: … Neutral saponins of panax ginseng root …
Human Lactoferrin Peptide hLF1-11
Human Lactoferrin Peptide hLF1-11 is under investigation in clinical trial NCT00509834 (A Study on the Tolerability and Early Efficacy of Hlf1-11 in Patients With Proven Candidaemia).
Investigational
Matched Synonyms: … N-terminal peptide of human lactoferrin 1-11 …
Matched Description: … is under investigation in clinical trial NCT00509834 (A Study on the Tolerability and Early Efficacy of …
Matched Description: … is under investigation in clinical trial NCT00509834 (A Study on the Tolerability and Early Efficacy of …
Efzofitimod
Efzofitimod (ATYR1923) is a fusion protein comprised of the immuno-modulatory domain of histidyl tRNA synthetase fused to the FC region of a human antibody. It is a selective modulator of neuropilin-2 that downregulates the innate and adaptive immune response in inflammatory disease states.
Investigational
Matched Synonyms: … Human IgG1Fc- iMod domain (amino acids 2-60) of human HARS fusion protein …
Matched Description: … Efzofitimod (ATYR1923) is a fusion protein comprised of the immuno-modulatory domain of histidyl tRNA ... synthetase fused to the FC region of a human antibody. ... It is a selective modulator of neuropilin-2 that downregulates the innate and adaptive immune response …
Matched Description: … Efzofitimod (ATYR1923) is a fusion protein comprised of the immuno-modulatory domain of histidyl tRNA ... synthetase fused to the FC region of a human antibody. ... It is a selective modulator of neuropilin-2 that downregulates the innate and adaptive immune response …
AD-114
Investigational
Matched Synonyms: … Human single domain antibody-like protein inhibitor of the chemokine receptor type 4 …
INZ-701
INZ-701 is an enzyme replacement therapy under development with the intention to be used for the treatment of calcification disorders of the circulatory system, bones, and kidneys.
Investigational
Matched Synonyms: … Recombinant human ectonucleotide pyrophosphatase/phosphodiesterase 1 fused to the Fc fragment of IGG1 …
Matched Description: … calcification disorders of the circulatory system, bones, and kidneys. ... is an enzyme replacement therapy under development with the intention to be used for the treatment of …
Matched Description: … calcification disorders of the circulatory system, bones, and kidneys. ... is an enzyme replacement therapy under development with the intention to be used for the treatment of …
Pemlimogene merolisbac
Pemlimogene merolisbac is under investigation in clinical trial NCT03371381 (An Efficacy and Safety Study of JNJ-64041757, a Live Attenuated Listeria Monocytogenes Immunotherapy, in Combination With Nivolumab Versus Nivolumab Monotherapy in Participants With Advanced Adenocarcinoma of the Lung).
Investigational
Matched Synonyms: … ), 5 tandem copies of a 21 amino acid fr ... ) expressing a fusion protein comprising the n-terminal 100 amino acids of the lm acta protein (actan100 ... Recombinant live-attenuated double-deleted (ladd) strain of listeria monocytogenes (lm .delta.acta/.delta.inlb …
Matched Description: … Pemlimogene merolisbac is under investigation in clinical trial NCT03371381 (An Efficacy and Safety Study of ... Combination With Nivolumab Versus Nivolumab Monotherapy in Participants With Advanced Adenocarcinoma of …
Matched Description: … Pemlimogene merolisbac is under investigation in clinical trial NCT03371381 (An Efficacy and Safety Study of ... Combination With Nivolumab Versus Nivolumab Monotherapy in Participants With Advanced Adenocarcinoma of …
CHF5633
CHF5633 is a fully synthetic pulmonary surfactant preparation comprising DPPC (dipalmitoylphosphatidylcholine), POPG Na (palmitoyl‐oleoyl‐phosphatidylglycerol sodium), a synthetic SP-C analogue, and a synthetic SP-B analogue.
Investigational
Matched Synonyms: … Synthetic surfactant comprised of DPPC, POPG Na, synthetic SP-C analogue and synthetic SP-B analogue …
QXL138AM
QXL138AM is a masked immunocytokine (MIC) comprised of an anti-CD138 immunoglobulin G1 antibody fused to interferon alpha 2a. It binds the CD138 protein on the surface of the tumour cells.
Investigational
Matched Synonyms: … Masked immunocytokine (MIC) comprised of an anti-CD138 immunoglobulin G1 antibody fused to interferon …
Matched Description: … It binds the CD138 protein on the surface of the tumour cells. ... QXL138AM is a masked immunocytokine (MIC) comprised of an anti-CD138 immunoglobulin G1 antibody fused …
Matched Description: … It binds the CD138 protein on the surface of the tumour cells. ... QXL138AM is a masked immunocytokine (MIC) comprised of an anti-CD138 immunoglobulin G1 antibody fused …
RGX-121
RGX-121 is designed to use the NAV AAV9 vector to deliver the human iduronate-2-sulfatase gene to the central nervous system.
Investigational
Matched Synonyms: … Non-replicating recombinant adeno-associated virus (AAV) vector of serotype 9 expressing human iduronate …
Silibinin
Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others. Silibinin is presented as a mixture of two diastereomers, silybin A and silybin B, which are found in an approximately equimolar...
Experimental
Investigational
Matched Synonyms: … Silybin A (constituent of milk thistle) …
Matched Description: … Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds ... , containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin ... Silibinin is presented as a mixture of two diastereomers, silybin A and silybin B, which are found in …
Matched Description: … Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds ... , containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin ... Silibinin is presented as a mixture of two diastereomers, silybin A and silybin B, which are found in …
WP-1122
WP-1122 is a prodrug of 2-deoxy-D-glucose (2-DG). It was granted FDA orphan designation for the treatment of glioblastoma multiforme.
Investigational
Matched Synonyms: … an acetic acid diester of 2-deoxy-D-glucose …
Matched Description: … WP-1122 is a prodrug of 2-deoxy-D-glucose (2-DG). ... It was granted FDA orphan designation for the treatment of glioblastoma multiforme.[L47361] …
Matched Description: … WP-1122 is a prodrug of 2-deoxy-D-glucose (2-DG). ... It was granted FDA orphan designation for the treatment of glioblastoma multiforme.[L47361] …
Demplatin pegraglumer
Demplatin pegraglumer is under investigation in clinical trial NCT02043288 (Combination Therapy With NC-6004 and Gemcitabine Versus Gemcitabine Alone in Pancreatic Cancer).
Investigational
Matched Synonyms: … A micelle drug formulation composed of cisplatin and mPEG-poly(l-Glu) diblock copolymer with 1,3-propanediyl ... linkagecisplatin is incorporated in polymeric micelles via polymer-metal complex formation with cis-geometry of …
ETX101
ETX101 is a non-replicating recombinant adeno associated viral vector, serotype 9, designed to promote increased transcription of SCN1A gene.
Investigational
Matched Synonyms: … recombinant adeno associated viral vector, serotype 9, designed to promote increased transcription of …
Matched Description: … recombinant adeno associated viral vector, serotype 9, designed to promote increased transcription of …
Matched Description: … recombinant adeno associated viral vector, serotype 9, designed to promote increased transcription of …
Orvacabtagene autoleucel
Investigational
Matched Synonyms: … JCARH125 CONSISTS OF HUMAN CULTURE EXPANDED GENETICALLY MODIFIED AUTOLOGOUS T CELLS FOR CELL-BASED GENE ... CD4+ CD8+ T CELLS ARE DERIVED FROM ISOLATED BLOOD OF THE PATIENT AND ARE TRANSDUCED WITH NON-REPLICATIVE …
Mubodina
Mubodina is an investigational drug developed by Adienne Pharma & Biotech. It is a recombinant human minibody directed against complement component C5. It was investigated in various conditions including primary membranoproliferative glomerulonephritis and typical hemolytic uremic syndrome.
Investigational
Matched Synonyms: … Neutralizing scFv dimer to C5 fused at the C terminal end to the Fc domains of human IgG1 …
TPX-4589
TPX-4589 is an antibody-drug conjugate composed of a humanized monoclonal antibody targeting CLDN18.2 and linker-payload MC-VC-PAB-MMAE.
Investigational
Matched Synonyms: … Antibody drug conjugate composed of a humanized monoclonal antibody targeting CLDN18.2 and linker-payload …
Matched Description: … TPX-4589 is an antibody-drug conjugate composed of a humanized monoclonal antibody targeting CLDN18.2 …
Matched Description: … TPX-4589 is an antibody-drug conjugate composed of a humanized monoclonal antibody targeting CLDN18.2 …
Evorpacept
evorpacept is under investigation in clinical trial NCT04755244 (A Study of Evorpacept (ALX148) With Venetoclax and Azacitidine for Acute Myeloid Leukemia (ASPEN-05)).
Investigational
Matched Synonyms: … A CD47-binding, fusion protein containing a high affinity engineered D1 domain of human signal regulatory ... protein alpha (SIRPalpha) variant 1 (v1) genetically linked to a modified and inactive Fc domain of …
Matched Description: … evorpacept is under investigation in clinical trial NCT04755244 (A Study of Evorpacept (ALX148) With …
Matched Description: … evorpacept is under investigation in clinical trial NCT04755244 (A Study of Evorpacept (ALX148) With …
Vanglusagene ensiparvovec
Investigational
Matched Synonyms: … a secretable form of human acid a-glucosidase (GAA) ... bio-engineered capsid (AAV-Spark100) and a codon-optimized expression cassette to drive expression of …
Mycobacterium w. Vaccine
The Mycobacterium w (M.w) vaccine is a heat-killed suspension derived from a non-pathogenic mycobacterium: mycobacterium indicus pranii. As an immunotherapy, M.w is used against leprosy; the compound also shares antigens with M. tuberculosis. Its use has shown clinical improvement, rapid bacterial clearance, and enhanced immune responses to Mycobacterium leprae antigens....
Investigational
Matched Synonyms: … Suspension of heat killed (autoclaved) Mycobacterium w …
Matched Description: … As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials …
Matched Description: … As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials …
Depelestat
Investigational
Matched Synonyms: … Human recombinant neutrophil elastase inhibitor, homologue of the second kunitz domain of inter-alpha-trypsin …
Displaying drugs 3676 - 3700 of 8028 in total