Displaying drugs 1376 - 1400 of 1414 in total
Ularitide
Ularitide is a synthetic form of urodilatin, a naturally occurring human natriuretic peptide that is involved in regulating blood pressure and the excretion of water and sodium from the kidneys. Urodilatin is produced in the kidney and excreted into the urine, and thus exists in low levels naturally in the...
Investigational
Matched Iupac: … [(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S,3R)-2-amino-3-hydroxybutanamido ... (2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-{[(4R,10S,16S,19S,22S,28S,31S,34S,37S,40S,49S,52R)-52-[(2S)-2- ... -methyl-10-(2-methylpropyl)-37-[2-(methylsulfanyl)ethyl]-6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51 ... -5-carbamimidamidopentanamido]-3-hydroxypropanamido]-3-hydroxypropanamido]-49-benzyl-28-[(2S)-butan-2- ... yl]-31,40-bis(3-carbamimidamidopropyl)-19-(2-carbamoylethyl)-34-(carboxymethyl)-16-(hydroxymethyl)-22 …
Matched Description: … Ularitide is a synthetic form of urodilatin, a naturally occurring human natriuretic peptide that is ... Ularitide is currently in Phase 2 development as a potential treatment for patients with acute decompensated ... involved in regulating blood pressure and the excretion of water and sodium from the kidneys. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Description: … Ularitide is a synthetic form of urodilatin, a naturally occurring human natriuretic peptide that is ... Ularitide is currently in Phase 2 development as a potential treatment for patients with acute decompensated ... involved in regulating blood pressure and the excretion of water and sodium from the kidneys. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Ciglitazone
Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class.
Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones. Several analogues were later developed, some of which—such as pioglitazone and troglitazone—made it to the market....
Experimental
Matched Iupac: … 5-({4-[(1-methylcyclohexyl)methoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione …
Matched Description: … endothelial cell (HUVEC), and osteoblastogenesis in human mesenchymal stem cells. ... Ciglitazone significantly decreases VEGF production by human granulosa cells in an in vitro study, and ... Ciglitazone increases adipogenesis, decreases differentiation and angiogenesis in human umbilical vein …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … endothelial cell (HUVEC), and osteoblastogenesis in human mesenchymal stem cells. ... Ciglitazone significantly decreases VEGF production by human granulosa cells in an in vitro study, and ... Ciglitazone increases adipogenesis, decreases differentiation and angiogenesis in human umbilical vein …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
HPV-16 trojan peptide vaccine
HPV-16 trojan peptide vaccine is an investigational cancer immunotherapy consisting of a novel Trojan peptide complex, composed of human papilloma virus 16 (HPV 16) epitopes, to stimulate antigen-specific CD4 and CD8 T cell responses.
Investigational
Matched Description: … papilloma virus 16 (HPV 16) epitopes, to stimulate antigen-specific CD4 and CD8 T cell responses. ... is an investigational cancer immunotherapy consisting of a novel Trojan peptide complex, composed of human …
AV608
AV608 is a NK-1 antagonist. It is developed for the treatment of Social anxiety disorder (SAD), irritable bowel syndrome (IBS) and overactive bladder (OAB).
Investigational
Matched Description: … AV608 is a NK-1 antagonist. ... It is developed for the treatment of Social anxiety disorder (SAD), irritable bowel syndrome (IBS) and …
Sparteine
Sparteine is a plant alkaloid derived from Cytisus scoparius and Lupinus mutabilis which may chelate calcium and magnesium. It is a sodium channel blocker, so it falls in the category of class 1a antiarrhythmic agents. Sparteine is not currently FDA-approved for human use, and its salt, sparteine sulfate, is one...
Experimental
Withdrawn
Matched Description: … Sparteine is not currently FDA-approved for human use, and its salt, sparteine sulfate, is one of the ... calcium and magnesium. ... Sparteine is a plant alkaloid derived from _Cytisus scoparius_ and _Lupinus mutabilis_ which may chelate …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Tunicamycin
Tunicamycin is a mixture of homologous nucleoside antibiotics that inhibits the UDP-HexNAc: polyprenol-P HexNAc-1-P family of enzymes. One member of this family is the enzyme GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-acetylglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis in eukaryotes. Tunicamycin blocks...
Experimental
Matched Description: … Tunicamycin is produced by Streptomyces clavuligerus and Streptomyces lysosuperficus bacteria along with ... Tunicamycin blocks N-linked glycosylation (N-glycans) resulting in cell cycle arrest at the G1 phase in human ... is a mixture of homologous nucleoside antibiotics that inhibits the UDP-HexNAc: polyprenol-P HexNAc-1- …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Nucleic Acids, Nucleotides, and Nucleosides …
AGRO100
AGRO100 is an oligonucleotide that functions as an aptamer and binds to nucleolin, a protein found intranuclear in all cells, but uniquely expressed on the surface of tumor cells. Such binding leads to internalization of the complex, and a strong anti-proliferative response in the tumor cell.
Pre-clinical testing demonstrates that...
Investigational
Matched Description: … colon cancer, as well as malignant melanoma and leukemia. ... Such binding leads to internalization of the complex, and a strong anti-proliferative response in the ... AGRO100 is an oligonucleotide that functions as an aptamer and binds to nucleolin, a protein found intranuclear …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Nonivamide
Nonivamide is found in herbs and spices. It is an alkaloid from the Capsicum species. The structures of DB06774 and nonivamide differ only slightly with respect to the fatty acid moiety of the side chain (8-methyl nonenoic acid versus nonanoic acid) .
Nonivamide is a flavoring ingredient. Nonivamide is an...
Investigational
Matched Description: … Nonivamide is an organic compound and a capsaicinoid. ... It is an amide of pelargonic acid and _vanillylamine_. ... Nonivamide is found in herbs and spices. It is an alkaloid from the Capsicum species. …
Ceramide NP
Ceramide NP is a lipid molecule included in a group of lipid molecules called ceramides. Ceramides are major lipid components in the stratum corneum of the human skin. Ceramide 3 consists of a phytosphingosine backbone N-acylated with a saturated fatty acid (stearic acid) . It is widely used as a...
Experimental
Matched Iupac: … (9Z)-N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]octadec-9-enamide …
Matched Description: … Ceramides are major lipid components in the stratum corneum of the human skin. ... It is widely used as a moisturizer in various cosmetic and personal products. ... Together with ceramide 1, they synergistically improve the skin barrier function in humans [A27232, A27233 …
Matched Description: … Ceramides are major lipid components in the stratum corneum of the human skin. ... It is widely used as a moisturizer in various cosmetic and personal products. ... Together with ceramide 1, they synergistically improve the skin barrier function in humans [A27232, A27233 …
Lintuzumab satetraxetan AC-225
Lintuzumab actinium Ac-225 is under investigation in clinical trial NCT00672165 (Targeted Atomic Nano-Generators (Actinium-225-Labeled Humanized Anti-CD33 Monoclonal Antibody HuM195) in Patients With Advanced Myeloid Malignancies).
Investigational
Selamectin
Selamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in dogs as well as prevent heartworms, fleas, ear mites, hookworms, and roundworms in cats. It also removes 2 types of...
Vet approved
Matched Iupac: … (1'R,2R,4'S,5S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'Z,24'S)-6-cyclohexyl-24'-hydroxy-12'-{[(2R,4S, ... 5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-21'-(hydroxyimino)-5,11',13',22'-tetramethyl-3',7', ... 19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1^{4,8}.0^{20,24}]pentacosane]-10',14',16',22'-tetraen-2' …
Matched Description: … It also removes 2 types of lungworm in cats and one type of lungworm in dogs. ... It is structurally related to ivermectin and milbemycin. Selamectin is not approved for human use. ... Selamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections …
Matched Description: … It also removes 2 types of lungworm in cats and one type of lungworm in dogs. ... It is structurally related to ivermectin and milbemycin. Selamectin is not approved for human use. ... Selamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections …
KP-1461
KP-1461 is a potent, non-chain-terminating, mutagenic deoxyribonucleoside analogue. Designated a DNA covert nucleoside, the drug consists of a modified base that incorporates randomly into HIV and pairs with multiple bases.
Investigational
Matched Iupac: … -2-yl}carbamate ... heptyl N-{5-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-oxo-1,4,5,6-tetrahydro-1,3,5-triazin …
Matched Description: … Designated a DNA covert nucleoside, the drug consists of a modified base that incorporates randomly into HIV and …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Description: … Designated a DNA covert nucleoside, the drug consists of a modified base that incorporates randomly into HIV and …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
SEA-BCMA
Investigational
Interferon Kappa
Interferon kappa is a subclass of type I interferon mediating host defence which consists of 207 amino acids and has 30% homology with others of the same class as it consists of a series of cysteine and a 27-amino acid signal peptide conserved in type I interferons. This gene encoding...
Investigational
Matched Description: … This gene encoding for this interferon is expressed in human epidermal keratinocytes. ... has 30% homology with others of the same class as it consists of a series of cysteine and a 27-amino ... Interferon kappa is a subclass of type I interferon mediating host defence which consists of 207 amino acids and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
IMGN632
Investigational
N,N-dimethylarginine
Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells which is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a...
Experimental
Matched Iupac: … (2S)-2-amino-5-[(E)-[amino(dimethylamino)methylidene]amino]pentanoic acid …
Matched Description: … It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human ... ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human ... ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
ATX-101
ATX-101 (medical), sodium deoxycholate for subcutaneous injection, is being evaluated as a treatment for the reduction of localized fat deposits. This includes treatment of superficial lipomas (benign tumors of soft tissue composed of mature fat cells), fat deposits in the submental region of the face/neck, and localized fat deposits in...
Investigational
Matched Description: … of soft tissue composed of mature fat cells), fat deposits in the submental region of the face/neck, and ... As a naturally occurring component of the human body, deoxycholate is considered a ‘biocompatible’ detergent …
Sugemalimab
Sugemalimab is a fully human, full-length IgG4 monoclonal anti-PD-L1 antibody discovered by CStone Pharmaceuticals and being investigated against relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma (R/R ENKTL) in adult patients and T-cell lymphoma.[L32868, L32873] It has been granted the Breakthrough Therapy Designation by the FDA to treat R/R ENKTL...
Investigational
Matched Description: … Sugemalimab is a fully human, full-length IgG4 monoclonal anti-PD-L1 antibody discovered by CStone Pharmaceuticals ... (R/R ENKTL) in adult patients and T-cell lymphoma. ... and being investigated against relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma …
Matched Categories: … PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Categories: … PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
LV-SMENP Vaccine
LV-SMENP-DC is a vaccine candidate being developed by Shenzhen Geno-Immune Medical Institute that comprises dendritic cells that are modified with lentiviral vector-expressing synthetic minigene which are based on domains of selected viral proteins. This vaccine is also administered with antigen-specific cytotoxic T lymphocytes (CTLs).
As of August 2020, this vaccine...
Investigational
Matched Description: … As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials …
Gantenerumab
Alzheimer's disease (AD) is the most common cause of dementia in elderly patients, with classical histopathological hallmarks including extracellular amyloid-beta (Aβ) plaques and intraneuronal neurofibrillary tangles (NFTs). As the classical view of AD pathology posits that Aβ accumulation triggers tau hyperphosphorylation and aggregation to form NFTs and cause neurodegeneration, large...
Investigational
Matched Description: … [A244705, A244710, A244745]
Gantenerumab is a fully human IgG1κ monoclonal antibody derived from the ... Aβ oligomers and fibrils over monomers. ... to reduce Aβ aggregation and remove Aβ plaques. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
COVID19 s-vax loaded autologous dendritic cell vaccine
Dendritic cells (DCs) can be derived and differentiated from peripheral blood mononuclear cells in the presence of specific cytokines and growth factors. These cells are then loaded with antigens produced by a virus or tumor cell and administered as a vaccine.
Dendritic Cells (DCs) are showing potential as natural adjuvants...
Investigational
Matched Description: … The rationale is that loading a DC cell with SARS-Cov-2 antigens and administering it as a vaccine can ... As of May 2020, the company is pursuing a human clinical trial (ChiCTR2000033003) to test the safety ... and immunogenicity of the vaccine. …
Odronextamab
Odronextamab is a hinge-stabilized, fully human immunoglobulin G4 (IgG4)-based CD20×CD3 bispecific antibody currently evaluated for the treatment of relapsed/refractory (R/R) B-Cell non-Hodgkin lymphoma (NHL).[A254187,A254197] Preliminary studies have shown that in patients with R/R NHL, the use of odronextamab does not lead to the development of neurologic toxicity; however, it can...
Investigational
Matched Description: … Odronextamab is a hinge-stabilized, fully human immunoglobulin G4 (IgG4)-based CD20×CD3 bispecific antibody ... [A254187] In December 2020, the FDA placed a partial clinical hold and requested the drug developer, …
ABBV-011
ABBV-011 is an antibody-drug conjugate of humanized, cysteine-engineered IgG1 monoclonal antibody targeting seizure-related 6 homolog conjugated to N-acetyl-gamma-calicheamicin.
Investigational
Xylazine
Xylazine is a clonidine analog used as a non-opioid tranquilizer in veterinary medicine and as an emetic, especially in cats.[A9095,L42675,A251420] It acts as an agonist at α2 adrenoceptors; however, its affinity is lower than the one reported for other α2 adrenergic receptor agonists such as detomidine and medetomidine. Xylazine is...
Vet approved
Matched Iupac: … N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine …
Matched Description: … [A32545] Xylazine is not approved for human use and requires a veterinary licence for its purchase and ... [L42675] Xylazine is sometimes used as an adulterant and combined with opioids and recreational drugs ... [A9096] The use of xylazine can lead to hypotension and bradycardia[A9092,A9093], and when combined with …
Matched Categories: … Hypnotics and Sedatives ... Heterocyclic Compounds, 1-Ring ... Adrenergic alpha-2 Receptor Agonists …
Matched Description: … [A32545] Xylazine is not approved for human use and requires a veterinary licence for its purchase and ... [L42675] Xylazine is sometimes used as an adulterant and combined with opioids and recreational drugs ... [A9096] The use of xylazine can lead to hypotension and bradycardia[A9092,A9093], and when combined with …
Matched Categories: … Hypnotics and Sedatives ... Heterocyclic Compounds, 1-Ring ... Adrenergic alpha-2 Receptor Agonists …
Displaying drugs 1376 - 1400 of 1414 in total