Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

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Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

Nature. 1998 Jun 11;393(6685):537-44.

PubMed ID
9634230 [ View in PubMed
]
Abstract

Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Possible cellulase CelA1 (Endoglucanase) (Endo-1,4-beta-glucanase) (FI-cmcase) (Carboxymethyl cellulase)Q79G13Details
Cyclopropane mycolic acid synthase MmaA2Q79FX6Details
CyclaseO07732Details
Conserved proteinO53240Details
Hydroxymycolate synthase MmaA4Q79FX8Details
Possible exported proteinO06796Details
DNA-directed RNA polymerase subunit beta'P9WGY7Details
Probable arabinosyltransferase AP9WNL9Details
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseP9WNC7Details
Probable arabinosyltransferase BP9WNL7Details
Enoyl-[acyl-carrier-protein] reductase [NADH]P9WGR1Details
Catalase-peroxidaseP9WIE5Details
Probable arabinosyltransferase CP9WNL5Details
Cyclopropane mycolic acid synthase 2P9WPB5Details
Thymidylate kinaseP9WKE1Details
6,7-dimethyl-8-ribityllumazine synthaseP9WHE9Details
Deoxyuridine 5'-triphosphate nucleotidohydrolaseP9WNS5Details
Nicotinate-nucleotide pyrophosphorylase [carboxylating]P9WJJ7Details
Cell division protein FtsZP9WN95Details
NADPH-ferredoxin reductase FprAP9WIQ3Details
Pantothenate synthetaseP9WIL5Details
Purine nucleoside phosphorylaseP9WP01Details
Serine/threonine-protein kinase PknBP9WI81Details
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenaseP9WGT1Details
Diacylglycerol acyltransferase/mycolyltransferase Ag85CP9WQN9Details
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolaseP9WGY3Details
3-oxoacyl-[acyl-carrier-protein] synthase 3P9WNG3Details
2-isopropylmalate synthaseP9WQB3Details
Malate synthase GP9WK17Details
Isocitrate lyaseP9WKK7Details
3-dehydroquinate dehydrataseP9WPX7Details
Mycocyclosin synthaseP9WPP7Details
Dihydrofolate reductaseP9WNX1Details
Dihydropteroate synthaseP9WND1Details
4-hydroxy-tetrahydrodipicolinate reductaseP9WP23Details
D-3-phosphoglycerate dehydrogenaseP9WNX3Details
Cyclopropane mycolic acid synthase 3P9WPB3Details
Glutamine synthetaseP9WN39Details
Group 1 truncated hemoglobin GlbNP9WN25Details
Aminoglycoside 2'-N-acetyltransferaseP9WQG9Details
Inositol-3-phosphate synthaseP9WKI1Details
Citrate lyase subunit beta-like proteinP9WPE1Details
Guanylate kinaseP9WKE9Details
Mycothiol acetyltransferaseP9WJM7Details
1,4-dihydroxy-2-naphthoyl-CoA synthaseP9WNP5Details
HTH-type transcriptional regulator EthRP9WMC1Details
Ribose-5-phosphate isomerase BP9WKD7Details
NAD(P)H dehydrogenase (quinone)P9WHH7Details
UDP-galactopyranose mutaseP9WIQ1Details
Probable thiol peroxidaseP9WG35Details
dTDP-4-dehydrorhamnose 3,5-epimeraseP9WH11Details
Proteasome subunit alphaP9WHU1Details
Cyclopropane mycolic acid synthase 1P9WPB7Details
AdenosylhomocysteinaseP9WGV3Details
Serine/threonine-protein kinase PknGP9WI73Details
OctanoyltransferaseP9WK83Details
ATP-dependent dethiobiotin synthetase BioDP9WPQ5Details
Cytochrome P450 130P9WPN5Details
Methionine aminopeptidase 2P9WK19Details
(2Z,6E)-farnesyl diphosphate synthaseP9WFF5Details
Decaprenyl diphosphate synthaseP9WFF7Details
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolaseP9WNH5Details
Probable L-lysine-epsilon aminotransferaseP9WQ77Details
Proteasome subunit betaP9WHT9Details
Alpha-pyrone synthesis polyketide synthase-like Pks18P9WPF1Details
R2-like ligand binding oxidaseP9WH69Details
Peptide deformylaseP9WIJ3Details
Iron-dependent extradiol dioxygenaseP9WNW7Details
3-oxoacyl-[acyl-carrier-protein] synthase 1P9WQD9Details
Secreted chorismate mutaseP9WIB9Details
Arylamine N-acetyltransferaseP9WJI5Details
ATP synthase subunit cP9WPS1Details
Deazaflavin-dependent nitroreductaseP9WP15Details
Nucleoid-associated protein Lsr2P9WIP7Details
Uncharacterized MFS-type transporter EfpAP9WJY5Details
16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAP9WJ63Details
Probable fatty acid synthase Fas (Fatty acid synthetase)P95029Details