Loperamide: novel effects on capacitative calcium influx.
Article Details
- CitationCopy to clipboard
Daly JW, Harper J
Loperamide: novel effects on capacitative calcium influx.
Cell Mol Life Sci. 2000 Jan 20;57(1):149-57.
- PubMed ID
- 10949586 [ View in PubMed]
- Abstract
Loperamide is a widely used antidiarrheal that primarily acts at nanomolar concentrations through activation of opioid receptors in the gastrointestinal tract. At somewhat higher concentrations, loperamide blocks calmodulin activity, calcium channels, N-methyl-D-aspartate-receptor channels, and maitotoxin-elicited calcium influx. Loperamide at micromolar concentrations has now been shown to have a remarkable stimulatory effect on the capacitative calcium influx that is triggered in many cells by depletion of the inositol-trisphosphate-sensitive stores of calcium in the endoplasmic reticulum. The mechanism whereby loperamide enhances levels of intracellular calcium elevated by capacitative calcium influx is, as yet, undefined.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Loperamide Calmodulin Protein Humans UnknownInhibitorDetails