Proton conduction through the M2 protein of the influenza A virus; a quantitative, mechanistic analysis of experimental data.
Article Details
- CitationCopy to clipboard
Lear JD
Proton conduction through the M2 protein of the influenza A virus; a quantitative, mechanistic analysis of experimental data.
FEBS Lett. 2003 Sep 18;552(1):17-22.
- PubMed ID
- 12972146 [ View in PubMed]
- Abstract
The M2 proton channel from influenza A virus forms proton-selective ion channels, which are the target of the drug amantadine. Here, existing experimental data are quantitatively examined for insights into mechanisms to account for the pH- and voltage-dependences of M2 proton conduction. The analysis shows that a model involving protonation equilibria of His37, including pH-dependent changes in the relative rates of diffusion on either side of the pore, is quantitatively able to account for recently reported electrophysiological data examining the pH- and voltage-dependences of Rostock and Weybridge strain M2 proton conduction.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Amantadine Matrix protein 2 Protein Influenza A virus (strain A/Ann Arbor/6/1960 H2N2) YesInhibitorDetails - Polypeptides
Name UniProt ID Matrix protein 2 P21430 Details