Effect of ketotifen on acute gastric lesions and gastric secretion in rats.
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Okabe S, Nakaji S, Tachibana M
Effect of ketotifen on acute gastric lesions and gastric secretion in rats.
Jpn J Pharmacol. 1992 Jun;59(2):251-4.
- PubMed ID
- 1434122 [ View in PubMed]
- Abstract
Ketotifen, a histamine H1-receptor antagonist and mast cell stabilizer, significantly protected the rat gastric mucosa against lesions induced by necrotizing agents, histamine or compound 48/80. The agent significantly inhibited the basal gastric acid secretion, but had little or no effect on the histamine-stimulated secretion. The mucosal protective effect was observed even at a dose that had little or no effect on gastric acid secretion, suggesting that ketotifen exhibits so-called cytoprotective activity.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Ketotifen Histamine H1 receptor Protein Humans YesAntagonistDetails