[Disorders with eosinophilia, treatment of hypereosinophilic syndrome].

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Borbenyi Z

[Disorders with eosinophilia, treatment of hypereosinophilic syndrome].

Orv Hetil. 2005 May 1;146(18 Suppl 1):911-6.

PubMed ID

15921304 [ View in PubMed

]

Abstract

Eosinophilia may be associated with reactive conditions and with clonal disorders of the hematopoietic cells. The hypereosinophilic syndrome takes an intermedier place in this group. In this disease a sustained eosinophilia with end organ damage can occur. The author summarized the diagnostic procedures and differential diagnosis in the group of these diseases focusing on characteristics and treatment of hypereosinophilic syndrome. The treatment has been varied and included steroids, hydroxyurea, interferon-alpha, and in some cases chemotherapy. On the basis of FIP1L1-PDGFRa fusion gene hypereosinophilic syndrome would be classified as a clonal disease and in the FIP1L1-PDGFRa positive cases the tyrosine kinase inhibitor imatinib mesylate (Glivec) would be effective.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Imatinib	Platelet-derived growth factor receptor alpha	Protein	Humans	Yes	Antagonist	Details