A gene outside the human MHC related to classical HLA class I genes.
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Hashimoto K, Hirai M, Kurosawa Y
A gene outside the human MHC related to classical HLA class I genes.
Science. 1995 Aug 4;269(5224):693-5.
- PubMed ID
- 7624800 [ View in PubMed]
- Abstract
By presenting antigenic peptides to T lymphocytes, major histocompatibility complex (MHC) class I molecules play important roles in the human immune system. Knowledge is limited on the evolutionary history of human MHC class I-related molecules. An expressed class I gene, MR1, has now been identified on human chromosome 1q25, outside the MHC. In contrast to other known human divergent class I genes, MR1 encodes peptide-binding domains similar to those encoded by human leukocyte antigen (HLA) class I genes on chromosome 6 and by nonmammalian classical MHC class I genes. This gene may thus contribute to understanding the evolution of the MHC.