Major histocompatibility complex class I-related gene protein
Details
- Name
- Major histocompatibility complex class I-related gene protein
- Synonyms
- Class I histocompatibility antigen-like protein
- MHC class I-related gene protein
- Gene Name
- MR1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006881|Major histocompatibility complex class I-related gene protein MGELMAFLLPLIIVLMVKHSDSRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDS VTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGC ELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLE EECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNG EEIVQEIDYGDILPSGDGTYQAWASIELDPQSSNLYSCHVEHCGVHMVLQVPQESETIPL VMKAVSGSIVLVIVLAGVGVLVWRRRPREQNGAIYLPTPDR
- Number of residues
- 341
- Molecular Weight
- 39365.76
- Theoretical pI
- 6.27
- GO Classification
- FunctionsMHC class I receptor activity / peptide antigen bindingProcessesantigen processing and presentation of peptide antigen via MHC class I / cytokine production involved in immune response / defense response to Gram-negative bacterium / immune response / innate immune response / interleukin-1 beta production / interleukin-17 production / signal transductionComponentsendoplasmic reticulum / endoplasmic reticulum membrane / extracellular region / integral component of membrane / MHC class I protein complex / plasma membrane
- General Function
- Peptide antigen binding
- Specific Function
- Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.
- Pfam Domain Function
- Transmembrane Regions
- 303-323
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0012485|Major histocompatibility complex class I-related gene protein (MR1) ATGGGGGAACTGATGGCGTTCCTGTTACCTCTCATCATTGTGTTAATGGTGAAGCACAGC GATTCCCGGACGCACTCTCTGAGATATTTTCGCCTGGGCGTTTCGGATCCCATCCATGGG GTCCCTGAATTTATTTCGGTTGGGTACGTGGACTCGCACCCTATCACCACATATGACAGT GTCACTCGGCAGAAGGAGCCACGGGCCCCATGGATGGCAGAGAACCTCGCGCCTGATCAC TGGGAGAGGTACACTCAGCTGCTGAGGGGCTGGCAGCAGATGTTCAAGGTGGAACTGAAG CGCCTACAGAGGCACTACAATCACTCAGATAATGTGGCTCACACCATCAAGCAGGCATGG GAGGCCAATCAGCATGAGTTGCTGTATCAAAAGAATTGGCTGGAAGAAGAATGTATTGCC TGGCTAAAGAGATTCCTGGAGTATGGGAAAGACACCCTACAAAGAACAGAGCCCCCACTG GTCAGAGTAAATCGCAAAGAAACTTTTCCAGGGGTTACAGCTCTCTTCTGCAAAGCTCAT GGCTTTTACCCCCCAGAAATTTACATGACATGGATGAAAAACGGGGAAGAAATTGTCCAA GAAATTGATTATGGAGACATTCTTCCCAGTGGGGATGGAACCTATCAGGCGTGGGCATCA ATTGAGCTTGATCCTCAGAGCAGCAACCTTTACTCCTGTCATGTGGAGCACTGCGGTGTC CACATGGTTCTTCAGGTCCCCCAGGAATCAGAAACTATCCCTCTTGTGATGAAAGCTGTC TCTGGGTCCATTGTCCTTGTCATTGTGCTGGCTGGAGTTGGTGTTCTAGTCTGGAGAAGA AGGCCCCGAGAGCAAAATGGAGCCATCTACCTTCCAACACCAGATCGATGA
- Chromosome Location
- 1
- Locus
- 1q25.3
- External Identifiers
Resource Link UniProtKB ID Q95460 UniProtKB Entry Name HMR1_HUMAN GenBank Protein ID 940354 GenBank Gene ID U22963 HGNC ID HGNC:4975 - General References
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