Cyclooxygenase-1 inhibition shortens the duration of diazepam-induced loss of righting reflex in mice.

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Liu X, Lee TL, Wong PT

Cyclooxygenase-1 inhibition shortens the duration of diazepam-induced loss of righting reflex in mice.

Anesth Analg. 2006 Jan;102(1):135-40.

PubMed ID

16368818 [ View in PubMed

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Abstract

Cyclooxygenase-1 (COX-1) inhibition by a selective inhibitor valeryl salicylate, or nonselective inhibitors at 10 mg/kg, including aspirin, ibuprofen, indomethacin, and picroxicam, attenuated by 29%-46% the duration of loss of righting reflex induced by diazepam (20 mg/kg) in mice. On the other hand, arachidonic acid (20 mg/kg) increased the duration of diazepam-induced loss of righting reflex by 48%. This effect of arachidonic acid was abolished by aspirin. However, aspirin at 10 mg/kg also did not alter the effects of diazepam (5 mg/kg) on spontaneous activity and rotarod performance. These findings strongly suggest that one or more COX products, most likely prostaglandins, play a significant role in modulating the hypnotic effect of diazepam. Elucidating the mechanism involved may further our understanding of the pharmacology of benzodiazepines.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Magnesium salicylate	Prostaglandin G/H synthase 1	Protein	Humans	Yes	Inhibitor	Details
Salicylic acid	Prostaglandin G/H synthase 1	Protein	Humans	Yes	Inhibitor	Details