Donepezil and flight simulator performance: effects on retention of complex skills.

Article Details

Citation
Copy to clipboard

Yesavage JA, Mumenthaler MS, Taylor JL, Friedman L, O'Hara R, Sheikh J, Tinklenberg J, Whitehouse PJ

Donepezil and flight simulator performance: effects on retention of complex skills.

Neurology. 2002 Jul 9;59(1):123-5.

PubMed ID
12105320 [ View in PubMed
]
Abstract

We report a randomized, double-blind, parallel group, placebo-controlled study to test the effects of the acetylcholinesterase inhibitor, donepezil (5 mg/d for 30 days), on aircraft pilot performance in 18 licensed pilots with mean age of 52 years. After 30 days of treatment, the donepezil group showed greater ability to retain the capacity to perform a set of complex simulator tasks than the placebo group, p < 0.05. Donepezil appears to have beneficial effects on retention of training on complex aviation tasks in nondemented older adults.

DrugBank Data that Cites this Article

Drugs