You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameDonepezil
Accession NumberDB00843  (APRD00039)
TypeSmall Molecule
GroupsApproved
DescriptionDonepezil (Aricept), is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. Donepezil has been tested in other cognitive disorders including Lewy body dementia and Vascular dementia, but it is not currently approved for these indications. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, and Down syndrome.
Structure
Thumb
Synonyms
Domepezil
Donepezil
Donepezil
Donepezilo
Donepezilum
External Identifiers
  • BNAG
  • E 2020
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Accel-donepeziltablet5 mgoralAccel Pharma Inc2014-09-04Not applicableCanada
Accel-donepeziltablet10 mgoralAccel Pharma Inc2014-09-04Not applicableCanada
Act Donepeziltablet5 mgoralActavis Pharma Company2013-12-27Not applicableCanada
Act Donepeziltablet10 mgoralActavis Pharma Company2013-12-27Not applicableCanada
Act Donepezil ODTtablet (orally disintegrating)5 mgoralActavis Pharma Company2013-12-27Not applicableCanada
Act Donepezil ODTtablet (orally disintegrating)10 mgoralActavis Pharma Company2013-12-27Not applicableCanada
Ag-donepeziltablet5 mgoralAngita Pharma Inc.Not applicableNot applicableCanada
Ag-donepeziltablet10 mgoralAngita Pharma Inc.Not applicableNot applicableCanada
Aricepttablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.1996-11-25Not applicableUs
Aricepttablet, film coated5 mg/1oralEisai Inc.1996-11-25Not applicableUs
Aricepttablet, film coated10 mg/1oralbryant ranch prepack1996-11-25Not applicableUs
Aricepttablet, film coated10 mg/1oralEisai Inc.1996-11-25Not applicableUs
Aricepttablet, film coated5 mg/1oralCardinal Health1996-11-26Not applicableUs
Aricepttablet5 mgoralPfizer Canada Inc1997-08-20Not applicableCanada
Aricepttablet, film coated5 mg/1oralPhysicians Total Care, Inc.2008-05-09Not applicableUs
Aricepttablet, film coated23 mg/1oralEisai Inc.2010-07-23Not applicableUs
Aricepttablet, film coated10 mg/1oralCardinal Health1996-11-26Not applicableUs
Aricepttablet10 mgoralPfizer Canada Inc1997-08-20Not applicableCanada
Aricepttablet, film coated10 mg/1oralPhysicians Total Care, Inc.2005-05-09Not applicableUs
Aricept ODTtablet, orally disintegrating10 mg/1oralEisai Inc.2004-10-18Not applicableUs
Aricept ODTtablet, orally disintegrating5 mg/1oralEisai Inc.2004-10-18Not applicableUs
Aricept Rdttablet (orally disintegrating)5 mgoralPfizer Canada Inc2006-01-02Not applicableCanada
Aricept Rdttablet (orally disintegrating)10 mgoralPfizer Canada Inc2006-01-02Not applicableCanada
Auro-donepeziltablet10 mgoralAuro Pharma Inc2013-12-27Not applicableCanada
Auro-donepeziltablet5 mgoralAuro Pharma Inc2013-12-27Not applicableCanada
Bio-donepeziltablet10 mgoralBiomed Pharma2013-12-27Not applicableCanada
Bio-donepeziltablet5 mgoralBiomed Pharma2013-12-27Not applicableCanada
Dom-donepeziltablet10 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-donepeziltablet5 mgoralDominion PharmacalNot applicableNot applicableCanada
Donepeziltablet5 mgoralSivem Pharmaceuticals Ulc2014-02-11Not applicableCanada
Donepeziltablet10 mgoralSanis Health IncNot applicableNot applicableCanada
Donepeziltablet10 mgoralPro Doc Limitee2013-12-30Not applicableCanada
Donepeziltablet10 mgoralSivem Pharmaceuticals Ulc2014-02-11Not applicableCanada
Donepeziltablet5 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Donepeziltablet5 mgoralSanis Health IncNot applicableNot applicableCanada
Donepeziltablet5 mgoralPro Doc Limitee2013-12-30Not applicableCanada
Donepeziltablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Donepezil Hydrochloridetablet, film coated5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1996-11-26Not applicableUs
Donepezil Hydrochloridetablet5 mgoralJubilant Generics LimitedNot applicableNot applicableCanada
Donepezil Hydrochloridetablet, film coated5 mg/1oralCardinal Health1996-11-26Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralGreenstone LLC1996-11-262015-12-29Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralGreenstone LLC1996-11-26Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1996-11-26Not applicableUs
Donepezil Hydrochloridetablet10 mgoralJubilant Generics LimitedNot applicableNot applicableCanada
Donepezil Hydrochloridetablet, film coated5 mg/1oralContract Pharmacy Services Pa2011-01-31Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralContract Pharmacy Services Pa2011-01-31Not applicableUs
Donepezil Hydrochloride ODTtablet, orally disintegrating5 mg/1oralGreenstone LLC2004-10-18Not applicableUs
Donepezil Hydrochloride ODTtablet, orally disintegrating10 mg/1oralGreenstone LLC2004-10-18Not applicableUs
Donepezil Hydrochloride Tabletstablet10 mgoralAccord Healthcare Inc2013-12-27Not applicableCanada
Donepezil Hydrochloride Tabletstablet5 mgoralAccord Healthcare Inc2013-12-27Not applicableCanada
Donepezil Hydrochloride Tablets USPtablet5 mgoralDr Reddys Laboratories LtdNot applicableNot applicableCanada
Donepezil Hydrochloride Tablets USPtablet10 mgoralDr Reddys Laboratories LtdNot applicableNot applicableCanada
Ecl-donepeziltablet5 mgoralEcl Pharma Group LtdNot applicableNot applicableCanada
Ecl-donepeziltablet10 mgoralEcl Pharma Group LtdNot applicableNot applicableCanada
Ipg-donepeziltablet5 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-donepeziltablet10 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Jamp-donepeziltablet5 mgoralJamp Pharma Corporation2013-12-27Not applicableCanada
Jamp-donepeziltablet10 mgoralJamp Pharma Corporation2013-12-27Not applicableCanada
Jamp-donepezil Tabletstablet10 mgoralJamp Pharma Corporation2014-09-26Not applicableCanada
Jamp-donepezil Tabletstablet5 mgoralJamp Pharma Corporation2014-09-26Not applicableCanada
Mar-donepeziltablet5 mgoralMarcan Pharmaceuticals Inc2014-01-06Not applicableCanada
Mar-donepeziltablet10 mgoralMarcan Pharmaceuticals Inc2014-01-06Not applicableCanada
Mint-donepeziltablet5 mgoralMint Pharmaceuticals IncNot applicableNot applicableCanada
Mint-donepeziltablet10 mgoralMint Pharmaceuticals IncNot applicableNot applicableCanada
Mylan-donepeziltablet5 mgoralMylan Pharmaceuticals Ulc2013-12-27Not applicableCanada
Mylan-donepeziltablet10 mgoralMylan Pharmaceuticals Ulc2013-12-27Not applicableCanada
Nat-donepeziltablet5 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada
Nat-donepeziltablet10 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada
PMS-donepeziltablet5 mgoralPharmascience Inc2013-12-27Not applicableCanada
PMS-donepeziltablet10 mgoralPharmascience Inc2013-12-27Not applicableCanada
Priva-donepeziltablet10 mgoralPharmapar IncNot applicableNot applicableCanada
Priva-donepeziltablet5 mgoralPharmapar IncNot applicableNot applicableCanada
Ran-donepeziltablet5 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-12-24Not applicableCanada
Ran-donepeziltablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-12-24Not applicableCanada
Riva-donepeziltablet5 mgoralLaboratoire Riva Inc2013-12-27Not applicableCanada
Riva-donepeziltablet10 mgoralLaboratoire Riva Inc2013-12-27Not applicableCanada
Sandoz Donepeziltablet5 mgoralSandoz Canada Incorporated2013-12-27Not applicableCanada
Sandoz Donepeziltablet10 mgoralSandoz Canada Incorporated2013-12-27Not applicableCanada
Sandoz Donepezil ODTtablet (orally disintegrating)5 mgoralSandoz Canada Incorporated2014-03-19Not applicableCanada
Sandoz Donepezil ODTtablet (orally disintegrating)10 mgoralSandoz Canada Incorporated2014-03-19Not applicableCanada
Septa Donepeziltablet5 mgoralSepta Pharmaceuticals Inc2014-10-30Not applicableCanada
Septa Donepeziltablet10 mgoralSepta Pharmaceuticals Inc2014-10-30Not applicableCanada
Teva-donepeziltablet5 mgoralTeva Canada Limited2013-12-27Not applicableCanada
Teva-donepeziltablet10 mgoralTeva Canada Limited2013-12-27Not applicableCanada
Van-donepeziltablet5 mgoralVanc Pharmaceuticals Inc2015-06-02Not applicableCanada
Van-donepeziltablet10 mgoralVanc Pharmaceuticals Inc2015-06-02Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-donepeziltablet5 mgoralApotex Inc2013-12-27Not applicableCanada
Apo-donepeziltablet10 mgoralApotex Inc2014-12-27Not applicableCanada
Donepeziltablet5 mg/1oralCamber Pharmaceuticals, Inc.2015-02-02Not applicableUs
Donepeziltablet10 mg/1oralCamber Pharmaceuticals, Inc.2015-02-02Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralRanbaxy Pharmaceuticals Inc.2010-11-29Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralAurobindo Pharma Limited2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralSolco Healthcare US, LLC2011-11-01Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralTeva Pharmaceuticals USA Inc2011-05-312015-10-31Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralPhysicians Total Care, Inc.2010-12-27Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralJubilant Cadista Pharmaceuticals Inc.2011-05-29Not applicableUs
Donepezil Hydrochloridetablet, extended release23 mg/1oralT Wi Pharmaceuticals, Inc.2015-03-01Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralREMEDYREPACK INC.2015-05-20Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralWest ward Pharmaceutical Corp2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralWockhardt USA LLC.2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, film coated23 mg/1oralMacleods Pharmaceuticals Limited2014-01-23Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralZydus Pharmaceuticals (USA) Inc.2011-05-25Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralUnit Dose Services2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralCitron Pharma LLC2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralMajor Pharmaceuticals2011-05-31Not applicableUs
Donepezil Hydrochloridetablet10 mg/1oralSandoz Inc2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralAmerican Health Packaging2014-06-07Not applicableUs
Donepezil Hydrochloridetablet23 mg/1oralPar Pharmaceutical, Inc.2013-09-15Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralAlembic Pharmaceuticals Limited2016-01-29Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralCardinal Health2011-11-01Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralAmerican Health Packaging2015-07-15Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralMacleods Pharmaceuticals Limited2012-08-17Not applicableUs
Donepezil Hydrochloridetablet, orally disintegrating10 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2013-03-08Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralSun Pharmaceutical Industries Limited2011-06-01Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralMylan Pharmaceuticals Inc.2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralCadila Healthcare Limited2011-05-25Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralVensun Pharmaceuticals, Inc.2014-12-10Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralLucid Pharma Llc2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralBiomes Pharmaceuticals LLC2016-02-25Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralHikma Pharmaceutical2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralTorrent Pharmaceuticals Limited2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralbryant ranch prepack2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralContract Pharmacy Services Pa2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralActavis Inc.2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralPreferred Pharmaceuticals, Inc.2011-05-312015-10-31Us
Donepezil Hydrochloridetablet, film coated23 mg/1oralDr. Reddys Laboratories Limited2013-07-26Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralGolden State Medical Supply, Inc2014-10-29Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralREMEDYREPACK INC.2015-05-20Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralWest ward Pharmaceutical Corp2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralWockhardt USA LLC.2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralRebel Distributors Corp2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, orally disintegrating5 mg/1oralZydus Pharmaceuticals (USA) Inc.2011-05-11Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralREMEDYREPACK INC.2013-05-22Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralCitron Pharma LLC2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralCardinal Health2014-06-07Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2013-03-08Not applicableUs
Donepezil Hydrochloridetablet, orally disintegrating5 mg/1oralSandoz Inc2011-05-10Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralCarilion Materials Management2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralScie Gen Pharmaceuticals, Inc.2014-10-29Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralAlembic Pharmaceuticals Limited2016-01-29Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralCardinal Health2011-06-07Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralSt Marys Medical Park Pharmacy2014-05-22Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralMacleods Pharmaceuticals Limited2012-08-17Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralProficient Rx LP2011-05-29Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralMylan Pharmaceuticals Inc.2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralCadila Healthcare Limited2011-05-25Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.2011-06-01Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralMc Kesson Contract Packaging2013-04-10Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralLucid Pharma Llc2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralHikma Pharmaceutical2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralINDICUS PHARMA LLC2011-06-15Not applicableUs
Donepezil Hydrochloridetablet5 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2011-05-31Not applicableUs
Donepezil Hydrochloridetablet5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralContract Pharmacy Services Pa2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralDr. Reddys Laboratories Limited2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralGolden State Medical Supply, Inc2014-10-29Not applicableUs
Donepezil Hydrochloridetablet, film coated23 mg/1oralSun Pharmaceutical Industries Limited2015-06-17Not applicableUs
Donepezil Hydrochloridetablet, film coated23 mg/1oralActavis Pharma, Inc.2015-12-22Not applicableUs
Donepezil Hydrochloridetablet, orally disintegrating5 mg/1oralCadila Healthcare Limited2011-05-11Not applicableUs
Donepezil Hydrochloridetablet, extended release23 mg/1oralAv Kare, Inc.2015-03-11Not applicableUs
Donepezil Hydrochloridetablet, orally disintegrating10 mg/1oralZydus Pharmaceuticals (USA) Inc.2011-05-11Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralREMEDYREPACK INC.2013-05-24Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.2012-08-17Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralWockhardt Limited2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2013-03-08Not applicableUs
Donepezil Hydrochloridetablet, orally disintegrating10 mg/1oralSandoz Inc2011-05-10Not applicableUs
Donepezil Hydrochloridetablet23 mg/1oralLupin Pharmaceuticals, Inc.2015-12-21Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralScie Gen Pharmaceuticals, Inc.2014-10-29Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralAlembic Pharmaceuticals Inc.2016-01-29Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralCardinal Health2011-06-07Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralSt Marys Medical Park Pharmacy2014-05-22Not applicableUs
Donepezil Hydrochloridetablet, orally disintegrating5 mg/1oralMacleods Pharmaceuticals Limited2012-12-14Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralRanbaxy Pharmaceuticals Inc.2010-11-29Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralAurobindo Pharma Limited2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralSolco Healthcare US, LLC2011-11-01Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralMc Kesson Contract Packaging2013-04-10Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralPhysicians Total Care, Inc.2010-12-07Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralJubilant Cadista Pharmaceuticals Inc.2011-05-29Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralINDICUS PHARMA LLC2011-06-15Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralAmerican Health Packaging2015-07-15Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralAidarex Pharmaceuticals LLC2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, orally disintegrating5 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2013-03-08Not applicableUs
Donepezil Hydrochloridetablet5 mg/1oralSandoz Inc2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralAmerican Health Packaging2014-06-07Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralDr. Reddys Laboratories Limited2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralREMEDYREPACK INC.2013-07-25Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralBiomes Pharmaceuticals LLC2016-02-25Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralWockhardt Limited2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralTorrent Pharmaceuticals Limited2011-05-28Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralSun Pharmaceutical Industries Limited2011-06-01Not applicableUs
Donepezil Hydrochloridetablet, film coated23 mg/1oralMylan Pharmaceuticals Inc.2015-12-11Not applicableUs
Donepezil Hydrochloridetablet, orally disintegrating10 mg/1oralCadila Healthcare Limited2011-05-11Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralVensun Pharmaceuticals, Inc.2014-12-10Not applicableUs
Donepezil Hydrochloridetablet10 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralMajor Pharmaceuticals2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralZydus Pharmaceuticals (USA) Inc.2011-05-25Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralUnit Dose Services2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralAlembic Pharmaceuticals Inc.2016-01-29Not applicableUs
Donepezil Hydrochloridetablet, film coated5 mg/1oralCardinal Health2011-05-31Not applicableUs
Donepezil Hydrochloridetablet, film coated10 mg/1oralREMEDYREPACK INC.2014-12-18Not applicableUs
Donepezil Hydrochloridetablet, orally disintegrating10 mg/1oralMacleods Pharmaceuticals Limited2012-12-14Not applicableUs
Donepezil Hydrochloride 10 mgtablet, film coated10 mg/1oralCardinal Health2014-06-15Not applicableUs
Donepezil Hydrochloride 10 mgtablet, film coated10 mg/1oralMajor Pharmaceuticals2014-06-15Not applicableUs
Donepezil Hydrochloride 10mgtablet, film coated10 mg/1oralBionpharma Inc.2015-07-01Not applicableUs
Donepezil Hydrochloride 5 mgtablet, film coated5 mg/1oralCardinal Health2014-06-15Not applicableUs
Donepezil Hydrochloride 5 mgtablet, film coated5 mg/1oralMajor Pharmaceuticals2014-06-15Not applicableUs
Donepezil Hydrochloride 5 mgtablet, film coated5 mg/1oralAlembic Pharmaceuticals Limited2013-03-04Not applicableUs
Donepezil Hydrochloride 5 mgtablet, film coated10 mg/1oralAlembic Pharmaceuticals Limited2013-02-19Not applicableUs
Donepezil Hyrochloride 5mgtablet, film coated5 mg/1oralBionpharma Inc.2015-07-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AlzepilEgis
DaviaTerapia
DepzilPsyco Remedies
DoneceptActavis
DonecilABL Pharma
DonepAlkem
DonepexSchafer
DonesynSynthon
DopezilMedis
EranzWyeth
Memac Pfizer
Nomi-NoxJohnson
PezaleSandoz
RedumasTeva
ZolpezilActavis
Brand mixtures
NameLabellerIngredients
NamzaricForest Laboratories, Inc.
Salts
Name/CASStructureProperties
Donepezil hydrochloride
ThumbNot applicableDBSALT000938
Categories
UNII8SSC91326P
CAS number120014-06-4
WeightAverage: 379.492
Monoisotopic: 379.214743799
Chemical FormulaC24H29NO3
InChI KeyInChIKey=ADEBPBSSDYVVLD-UHFFFAOYSA-N
InChI
InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
IUPAC Name
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
SMILES
COC1=C(OC)C=C2C(=O)C(CC3CCN(CC4=CC=CC=C4)CC3)CC2=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as n-benzylpiperidines. These are heterocyclic Compounds containing a piperidine ring conjugated to a benzyl group through one nitrogen ring atom.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPiperidines
Sub ClassBenzylpiperidines
Direct ParentN-benzylpiperidines
Alternative Parents
Substituents
  • N-benzylpiperidine
  • Indanone
  • Indane
  • Aryl alkyl ketone
  • Aryl ketone
  • Phenylmethylamine
  • Benzylamine
  • Anisole
  • Aralkylamine
  • Alkyl aryl ether
  • Benzenoid
  • Monocyclic benzene moiety
  • Tertiary aliphatic amine
  • Tertiary amine
  • Ketone
  • Azacycle
  • Ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the palliative treatment of mild to moderate dementia of the Alzheimer's type.
PharmacodynamicsDonepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. An early pathophysiological feature of Alzheimer's disease that is associated with memory loss and cognitive deficits is a deficiency of acetylcholine as a result of selective loss of cholinergic neurons in the cerebral cortex, nucleus basalis, and hippocampus. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil's effect may lessen as the disease progresses and fewer cholinergic neurons remain functionally intact. There is no evidence that donepezil alters the course of the underlying dementing process.
Mechanism of actionDonepezil is a piperidine derivative that is a centerally active, reversible inhibitor of acetylcholinesterase. This drug is structurally unrelated to other anticholinesterase agents. Donepezil's proposed mechanism of action involves the reversible inhibition of cholinesterases (eg. acetylcholinesterase), which prevents the hydrolysis of acetycholine, and leads to an increased concentration of acetylcholine at cholinergic synapses. Evidence suggests that the anticholinesterase activity of donepezil is relatively specific for acetylcholinesterase in the brain.
Related Articles
AbsorptionDonepezil is well absorbed with a relative oral bioavailability of 100% and reaches peak plasma concentrations in 3 to 4 hours.
Volume of distribution
  • 12 L/kg
Protein binding96%
Metabolism

Donepezil is metabolized by CYP 450 isoenzymes 2D6 and 3A4 in the liver and also undergoes glucuronidation. The main metabolite, 6-O-desmethyl donepezil, has been reported to inhibit AChE to the same extent as donepezil in vitro.

SubstrateEnzymesProduct
Donepezil
5-O-DesmethyldonepezilDetails
Donepezil
6-O-DesmethyldonepezilDetails
Donepezil
Donepezil metabolite M4Details
Donepezil
Not Available
Donepezil metabolite M3Details
Donepezil
Not Available
Donepezil metabolite M5Details
Donepezil
Not Available
Donepezil metabolite M6Details
Donepezil metabolite M3
Not Available
Donepezil metabolite M7Details
Donepezil metabolite M7
Not Available
Donepezil metabolite M7 sulfateDetails
Donepezil metabolite M4
Not Available
Donepezil metabolite M8Details
5-O-Desmethyldonepezil
Not Available
Donepezil metabolite M9Details
6-O-Desmethyldonepezil
Not Available
Donepezil metabolite M9Details
Donepezil metabolite M9
Not Available
Donepezil metabolite M10Details
5-O-Desmethyldonepezil
Not Available
Donepezil metabolite M7Details
Donepezil metabolite M7
Not Available
Donepezil metabolite M10Details
6-O-Desmethyldonepezil
Not Available
Donepezil metabolite M11Details
5-O-Desmethyldonepezil
Not Available
Donepezil metabolite M12Details
Donepezil metabolite M9
Not Available
Donepezil metabolite M13Details
Donepezil metabolite M9
Not Available
Donepezil metabolite M14Details
Route of eliminationDonepezil is both excreted in the urine intact and extensively metabolized to four major metabolites, two of which are known to be active, and a number of minor metabolites, not all of which have been identified.
Half life70 hours
Clearance
  • apparent plasma cl=0.13 L/hr/kg
ToxicitySymptoms of overdose include severe nausea, vomiting, salivation, sweating, bradycardia, hypotension, respiratory depression, collapse and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9966
Blood Brain Barrier+0.9953
Caco-2 permeable+0.7742
P-glycoprotein substrateSubstrate0.7721
P-glycoprotein inhibitor IInhibitor0.7641
P-glycoprotein inhibitor IIInhibitor0.8202
Renal organic cation transporterInhibitor0.7696
CYP450 2C9 substrateNon-substrate0.8465
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateSubstrate0.7202
CYP450 1A2 substrateInhibitor0.5072
CYP450 2C9 inhibitorNon-inhibitor0.8189
CYP450 2D6 inhibitorInhibitor0.8684
CYP450 2C19 inhibitorNon-inhibitor0.8356
CYP450 3A4 inhibitorNon-inhibitor0.7411
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.6138
Ames testNon AMES toxic0.6441
CarcinogenicityNon-carcinogens0.9528
BiodegradationNot ready biodegradable0.9145
Rat acute toxicity3.0123 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.5386
hERG inhibition (predictor II)Inhibitor0.8095
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Eisai inc
  • Mutual pharmaceutical co inc
  • Teva pharmaceuticals usa inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral10 mg
Tabletoral5 mg
Tablet (orally disintegrating)oral10 mg
Tablet (orally disintegrating)oral5 mg
Tabletoral10 mg/1
Tabletoral23 mg/1
Tabletoral5 mg/1
Tablet, extended releaseoral23 mg/1
Tablet, film coatedoral10 mg/1
Tablet, film coatedoral23 mg/1
Tablet, film coatedoral5 mg/1
Tablet, orally disintegratingoral10 mg/1
Tablet, orally disintegratingoral5 mg/1
Capsuleoral
Prices
Unit descriptionCostUnit
Aricept ODT 30 5 mg Dispersible Tablet Box272.99USD box
Aricept 10 mg tablet10.93USD tablet
Aricept 5 mg tablet9.78USD tablet
Aricept odt 10 mg tablet8.03USD tablet
Aricept odt 5 mg tablet8.03USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA1338808 No1996-12-242013-12-24Canada
CA2252806 No2005-11-222017-06-06Canada
US4895841 No1993-11-252010-11-25Us
US5061703 Yes1995-10-112015-10-11Us
US7727548 No2002-06-232022-06-23Us
US7727552 No1998-03-262018-03-26Us
US8039009 Yes2009-09-242029-09-24Us
US8058291 No2009-12-052029-12-05Us
US8168209 Yes2006-05-222026-05-22Us
US8173708 Yes2006-05-222026-05-22Us
US8283379 Yes2006-05-222026-05-22Us
US8293794 No2005-11-222025-11-22Us
US8329752 Yes2006-05-222026-05-22Us
US8338485 No2005-11-222025-11-22Us
US8338486 No2005-11-222025-11-22Us
US8362085 Yes2006-05-222026-05-22Us
US8481565 No2006-10-042026-10-04Us
US8580858 No2005-11-222025-11-22Us
US8598233 Yes2006-05-222026-05-22Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point206.72 °CNot Available
water solubility2.931 mg/LNot Available
logP3.6Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0045 mg/mLALOGPS
logP4.14ALOGPS
logP4.21ChemAxon
logS-4.9ALOGPS
pKa (Strongest Acidic)17.02ChemAxon
pKa (Strongest Basic)8.62ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area38.77 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity112.11 m3·mol-1ChemAxon
Polarizability44.34 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Akio Imai, Hideaki Watanabe, Takashi Kajima, Yasushi Ishihama, Akiyo Ohtsuka, Tomohide Tanaka, Yukio Narabu, “Polymorphs of donepezil hydrochloride and process for production.” U.S. Patent US5985864, issued December, 1988.

US5985864
General References
  1. Xiong G, Doraiswamy PM: Combination drug therapy for Alzheimer's disease: what is evidence-based, and what is not? Geriatrics. 2005 Jun;60(6):22-6. [PubMed:15948662 ]
  2. Yesavage JA, Mumenthaler MS, Taylor JL, Friedman L, O'Hara R, Sheikh J, Tinklenberg J, Whitehouse PJ: Donepezil and flight simulator performance: effects on retention of complex skills. Neurology. 2002 Jul 9;59(1):123-5. [PubMed:12105320 ]
  3. Sugimoto H: Donepezil hydrochloride: a treatment drug for Alzheimer's disease. Chem Rec. 2001;1(1):63-73. [PubMed:11893059 ]
External Links
ATC CodesN06DA02N06DA53N06DA52
AHFS Codes
  • 12:04.00
PDB Entries
FDA labelDownload (303 KB)
MSDSDownload (58.2 KB)
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe risk or severity of adverse effects can be increased when 4-Androstenedione is combined with Donepezil.
AbirateroneThe metabolism of Donepezil can be decreased when combined with Abiraterone.
AcebutololDonepezil may increase the bradycardic activities of Acebutolol.
AcetylcholineThe risk or severity of adverse effects can be increased when Donepezil is combined with Acetylcholine.
AclidiniumThe therapeutic efficacy of Aclidinium can be decreased when used in combination with Donepezil.
AlclometasoneThe risk or severity of adverse effects can be increased when Alclometasone is combined with Donepezil.
AldosteroneThe risk or severity of adverse effects can be increased when Aldosterone is combined with Donepezil.
AlprenololDonepezil may increase the bradycardic activities of Alprenolol.
AmcinonideThe risk or severity of adverse effects can be increased when Amcinonide is combined with Donepezil.
AmiodaroneDonepezil may increase the bradycardic activities of Amiodarone.
Anisotropine MethylbromideThe therapeutic efficacy of Anisotropine Methylbromide can be decreased when used in combination with Donepezil.
AprepitantThe serum concentration of Donepezil can be increased when it is combined with Aprepitant.
ArecolineThe risk or severity of adverse effects can be increased when Donepezil is combined with Arecoline.
ArotinololDonepezil may increase the bradycardic activities of Arotinolol.
ArtemetherThe metabolism of Donepezil can be decreased when combined with Artemether.
AtazanavirThe metabolism of Donepezil can be decreased when combined with Atazanavir.
AtenololDonepezil may increase the bradycardic activities of Atenolol.
AtomoxetineThe metabolism of Donepezil can be decreased when combined with Atomoxetine.
Atracurium besylateThe therapeutic efficacy of Atracurium besylate can be decreased when used in combination with Donepezil.
AtropineThe therapeutic efficacy of Atropine can be decreased when used in combination with Donepezil.
Beclomethasone dipropionateThe risk or severity of adverse effects can be increased when Beclomethasone dipropionate is combined with Donepezil.
BefunololDonepezil may increase the bradycardic activities of Befunolol.
BenactyzineThe therapeutic efficacy of Benactyzine can be decreased when used in combination with Donepezil.
BendroflumethiazideBendroflumethiazide may increase the bradycardic activities of Donepezil.
BenzatropineThe therapeutic efficacy of Benzatropine can be decreased when used in combination with Donepezil.
BeractantDonepezil may increase the bradycardic activities of Beractant.
BetamethasoneThe risk or severity of adverse effects can be increased when Betamethasone is combined with Donepezil.
BetaxololDonepezil may increase the bradycardic activities of Betaxolol.
BethanecholThe risk or severity of adverse effects can be increased when Donepezil is combined with Bethanechol.
BevantololDonepezil may increase the bradycardic activities of Bevantolol.
BexaroteneThe serum concentration of Donepezil can be decreased when it is combined with Bexarotene.
BiperidenThe therapeutic efficacy of Biperiden can be decreased when used in combination with Donepezil.
BisoprololDonepezil may increase the bradycardic activities of Bisoprolol.
BoceprevirThe metabolism of Donepezil can be decreased when combined with Boceprevir.
BopindololDonepezil may increase the bradycardic activities of Bopindolol.
BortezomibThe metabolism of Donepezil can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Donepezil can be decreased when it is combined with Bosentan.
BretyliumBretylium may increase the bradycardic activities of Donepezil.
BudesonideThe risk or severity of adverse effects can be increased when Budesonide is combined with Donepezil.
BufuralolDonepezil may increase the bradycardic activities of Bufuralol.
BupranololDonepezil may increase the bradycardic activities of Bupranolol.
BupropionThe metabolism of Donepezil can be decreased when combined with Bupropion.
CalfactantDonepezil may increase the bradycardic activities of Calfactant.
CapecitabineThe metabolism of Donepezil can be decreased when combined with Capecitabine.
CarbacholThe risk or severity of adverse effects can be increased when Donepezil is combined with Carbachol.
CarbamazepineThe metabolism of Donepezil can be increased when combined with Carbamazepine.
CarteololDonepezil may increase the bradycardic activities of Carteolol.
CarvedilolDonepezil may increase the bradycardic activities of Carvedilol.
CelecoxibThe metabolism of Donepezil can be decreased when combined with Celecoxib.
CeliprololDonepezil may increase the bradycardic activities of Celiprolol.
CeritinibDonepezil may increase the bradycardic activities of Ceritinib.
CeritinibThe serum concentration of Donepezil can be increased when it is combined with Ceritinib.
CevimelineThe risk or severity of adverse effects can be increased when Donepezil is combined with Cevimeline.
ChloroquineThe metabolism of Donepezil can be decreased when combined with Chloroquine.
ChlorphenoxamineThe therapeutic efficacy of Chlorphenoxamine can be decreased when used in combination with Donepezil.
ChlorpromazineThe metabolism of Donepezil can be decreased when combined with Chlorpromazine.
CholecalciferolThe metabolism of Donepezil can be decreased when combined with Cholecalciferol.
CiclesonideThe risk or severity of adverse effects can be increased when Ciclesonide is combined with Donepezil.
CimetidineThe metabolism of Donepezil can be decreased when combined with Cimetidine.
CinacalcetThe metabolism of Donepezil can be decreased when combined with Cinacalcet.
CitalopramThe metabolism of Donepezil can be decreased when combined with Citalopram.
ClarithromycinThe metabolism of Donepezil can be decreased when combined with Clarithromycin.
ClemastineThe metabolism of Donepezil can be decreased when combined with Clemastine.
ClobazamThe metabolism of Donepezil can be decreased when combined with Clobazam.
Clobetasol propionateThe risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Donepezil.
ClocortoloneThe risk or severity of adverse effects can be increased when Clocortolone is combined with Donepezil.
ClomipramineThe metabolism of Donepezil can be decreased when combined with Clomipramine.
ClonidineClonidine may increase the bradycardic activities of Donepezil.
ClotrimazoleThe metabolism of Donepezil can be decreased when combined with Clotrimazole.
ClozapineThe metabolism of Donepezil can be decreased when combined with Clozapine.
CobicistatThe serum concentration of Donepezil can be increased when it is combined with Cobicistat.
CocaineThe metabolism of Donepezil can be decreased when combined with Cocaine.
ConivaptanThe serum concentration of Donepezil can be increased when it is combined with Conivaptan.
Cortisone acetateThe risk or severity of adverse effects can be increased when Cortisone acetate is combined with Donepezil.
CrizotinibThe metabolism of Donepezil can be decreased when combined with Crizotinib.
CrizotinibDonepezil may increase the bradycardic activities of Crizotinib.
CyclopentolateThe therapeutic efficacy of Cyclopentolate can be decreased when used in combination with Donepezil.
CyclosporineThe metabolism of Donepezil can be decreased when combined with Cyclosporine.
DabrafenibThe serum concentration of Donepezil can be decreased when it is combined with Dabrafenib.
DarifenacinThe therapeutic efficacy of Darifenacin can be decreased when used in combination with Donepezil.
DarifenacinThe metabolism of Donepezil can be decreased when combined with Darifenacin.
DarunavirThe serum concentration of Donepezil can be increased when it is combined with Darunavir.
DasatinibThe serum concentration of Donepezil can be increased when it is combined with Dasatinib.
DeferasiroxThe serum concentration of Donepezil can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with Donepezil.
dehydroepiandrosterone sulfateThe risk or severity of adverse effects can be increased when dehydroepiandrosterone sulfate is combined with Donepezil.
DelavirdineThe metabolism of Donepezil can be decreased when combined with Delavirdine.
DesipramineThe metabolism of Donepezil can be decreased when combined with Desipramine.
DesloratadineThe therapeutic efficacy of Desloratadine can be decreased when used in combination with Donepezil.
DesoximetasoneThe risk or severity of adverse effects can be increased when Desoximetasone is combined with Donepezil.
Desoxycorticosterone acetateThe risk or severity of adverse effects can be increased when Desoxycorticosterone acetate is combined with Donepezil.
DexamethasoneThe serum concentration of Donepezil can be decreased when it is combined with Dexamethasone.
Dexamethasone isonicotinateThe risk or severity of adverse effects can be increased when Dexamethasone isonicotinate is combined with Donepezil.
DexetimideThe therapeutic efficacy of Dexetimide can be decreased when used in combination with Donepezil.
DexmedetomidineDexmedetomidine may increase the bradycardic activities of Donepezil.
DicyclomineThe therapeutic efficacy of Dicyclomine can be decreased when used in combination with Donepezil.
DiflorasoneThe risk or severity of adverse effects can be increased when Diflorasone is combined with Donepezil.
DifluocortoloneThe risk or severity of adverse effects can be increased when Difluocortolone is combined with Donepezil.
DifluprednateThe risk or severity of adverse effects can be increased when Difluprednate is combined with Donepezil.
DigoxinDigoxin may increase the bradycardic activities of Donepezil.
DihydroergotamineThe metabolism of Donepezil can be decreased when combined with Dihydroergotamine.
DiltiazemThe metabolism of Donepezil can be decreased when combined with Diltiazem.
DiltiazemDonepezil may increase the bradycardic activities of Diltiazem.
DiphenhydramineThe metabolism of Donepezil can be decreased when combined with Diphenhydramine.
DipyridamoleThe therapeutic efficacy of Donepezil can be decreased when used in combination with Dipyridamole.
DoxycyclineThe metabolism of Donepezil can be decreased when combined with Doxycycline.
DronedaroneThe metabolism of Donepezil can be decreased when combined with Dronedarone.
DronedaroneDonepezil may increase the bradycardic activities of Dronedarone.
DuloxetineThe metabolism of Donepezil can be decreased when combined with Duloxetine.
EfavirenzThe serum concentration of Donepezil can be decreased when it is combined with Efavirenz.
EliglustatThe metabolism of Donepezil can be decreased when combined with Eliglustat.
EnzalutamideThe serum concentration of Donepezil can be decreased when it is combined with Enzalutamide.
EPIBATIDINEThe risk or severity of adverse effects can be increased when Donepezil is combined with EPIBATIDINE.
EquileninThe risk or severity of adverse effects can be increased when Equilenin is combined with Donepezil.
EquilinThe risk or severity of adverse effects can be increased when Equilin is combined with Donepezil.
ErythromycinThe metabolism of Donepezil can be decreased when combined with Erythromycin.
Eslicarbazepine acetateThe serum concentration of Donepezil can be decreased when it is combined with Eslicarbazepine acetate.
EsmololDonepezil may increase the bradycardic activities of Esmolol.
EstroneThe risk or severity of adverse effects can be increased when Estrone is combined with Donepezil.
EthopropazineThe therapeutic efficacy of Ethopropazine can be decreased when used in combination with Donepezil.
EtravirineThe serum concentration of Donepezil can be decreased when it is combined with Etravirine.
FesoterodineThe therapeutic efficacy of Fesoterodine can be decreased when used in combination with Donepezil.
FingolimodDonepezil may increase the bradycardic activities of Fingolimod.
FloxuridineThe metabolism of Donepezil can be decreased when combined with Floxuridine.
FluconazoleThe metabolism of Donepezil can be decreased when combined with Fluconazole.
FludrocortisoneThe risk or severity of adverse effects can be increased when Fludrocortisone is combined with Donepezil.
FlumethasoneThe risk or severity of adverse effects can be increased when Flumethasone is combined with Donepezil.
FlunisolideThe risk or severity of adverse effects can be increased when Flunisolide is combined with Donepezil.
Fluocinolone AcetonideThe risk or severity of adverse effects can be increased when Fluocinolone Acetonide is combined with Donepezil.
FluocinonideThe risk or severity of adverse effects can be increased when Fluocinonide is combined with Donepezil.
FluocortoloneThe risk or severity of adverse effects can be increased when Fluocortolone is combined with Donepezil.
FluorometholoneThe risk or severity of adverse effects can be increased when Fluorometholone is combined with Donepezil.
FluorouracilThe metabolism of Donepezil can be decreased when combined with Fluorouracil.
FluoxetineThe metabolism of Donepezil can be decreased when combined with Fluoxetine.
FluprednideneThe risk or severity of adverse effects can be increased when Fluprednidene is combined with Donepezil.
FluprednisoloneThe risk or severity of adverse effects can be increased when Fluprednisolone is combined with Donepezil.
FlurandrenolideThe risk or severity of adverse effects can be increased when Flurandrenolide is combined with Donepezil.
Fluticasone furoateThe risk or severity of adverse effects can be increased when Fluticasone furoate is combined with Donepezil.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Donepezil.
FluvastatinThe metabolism of Donepezil can be decreased when combined with Fluvastatin.
FluvoxamineThe metabolism of Donepezil can be decreased when combined with Fluvoxamine.
FosamprenavirThe metabolism of Donepezil can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Donepezil can be increased when it is combined with Fosaprepitant.
FosphenytoinThe metabolism of Donepezil can be increased when combined with Fosphenytoin.
Fusidic AcidThe serum concentration of Donepezil can be increased when it is combined with Fusidic Acid.
GalantamineGalantamine may increase the bradycardic activities of Donepezil.
Gallamine TriethiodideThe therapeutic efficacy of Gallamine Triethiodide can be decreased when used in combination with Donepezil.
GemfibrozilThe metabolism of Donepezil can be decreased when combined with Gemfibrozil.
GlycopyrroniumThe therapeutic efficacy of Glycopyrronium can be decreased when used in combination with Donepezil.
GTS-21The risk or severity of adverse effects can be increased when Donepezil is combined with GTS-21.
GuanfacineDonepezil may increase the bradycardic activities of Guanfacine.
HaloperidolThe metabolism of Donepezil can be decreased when combined with Haloperidol.
HexamethoniumThe therapeutic efficacy of Hexamethonium can be decreased when used in combination with Donepezil.
HomatropineThe therapeutic efficacy of Homatropine can be decreased when used in combination with Donepezil.
HydrocortisoneThe risk or severity of adverse effects can be increased when Hydrocortisone is combined with Donepezil.
HyoscyamineThe therapeutic efficacy of Hyoscyamine can be decreased when used in combination with Donepezil.
IdelalisibThe serum concentration of Donepezil can be increased when it is combined with Idelalisib.
ImatinibThe metabolism of Donepezil can be decreased when combined with Imatinib.
ImipramineThe metabolism of Donepezil can be decreased when combined with Imipramine.
IndenololDonepezil may increase the bradycardic activities of Indenolol.
IndinavirThe metabolism of Donepezil can be decreased when combined with Indinavir.
Ipratropium bromideThe therapeutic efficacy of Ipratropium bromide can be decreased when used in combination with Donepezil.
IrbesartanThe metabolism of Donepezil can be decreased when combined with Irbesartan.
IsavuconazoniumThe metabolism of Donepezil can be decreased when combined with Isavuconazonium.
IsoniazidThe metabolism of Donepezil can be decreased when combined with Isoniazid.
IsradipineThe metabolism of Donepezil can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Donepezil can be decreased when combined with Itraconazole.
IvabradineDonepezil may increase the bradycardic activities of Ivabradine.
IvacaftorThe serum concentration of Donepezil can be increased when it is combined with Ivacaftor.
KetoconazoleThe metabolism of Donepezil can be decreased when combined with Ketoconazole.
LabetalolDonepezil may increase the bradycardic activities of Labetalol.
LacosamideDonepezil may increase the atrioventricular blocking (AV block) activities of Lacosamide.
LanreotideDonepezil may increase the bradycardic activities of Lanreotide.
LeflunomideThe metabolism of Donepezil can be decreased when combined with Leflunomide.
LevobunololDonepezil may increase the bradycardic activities of Levobunolol.
LobelineThe risk or severity of adverse effects can be increased when Donepezil is combined with Lobeline.
LopinavirThe metabolism of Donepezil can be decreased when combined with Lopinavir.
LorcaserinThe metabolism of Donepezil can be decreased when combined with Lorcaserin.
LosartanThe metabolism of Donepezil can be decreased when combined with Losartan.
LovastatinThe metabolism of Donepezil can be decreased when combined with Lovastatin.
LucinactantDonepezil may increase the bradycardic activities of Lucinactant.
LuliconazoleThe serum concentration of Donepezil can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Donepezil can be decreased when it is combined with Lumacaftor.
LumefantrineThe metabolism of Donepezil can be decreased when combined with Lumefantrine.
MecamylamineThe therapeutic efficacy of Mecamylamine can be decreased when used in combination with Donepezil.
MedrysoneThe risk or severity of adverse effects can be increased when Medrysone is combined with Donepezil.
MelengestrolThe risk or severity of adverse effects can be increased when Melengestrol is combined with Donepezil.
MethacholineThe risk or severity of adverse effects can be increased when Donepezil is combined with Methacholine.
MethadoneThe metabolism of Donepezil can be decreased when combined with Methadone.
MethanthelineThe therapeutic efficacy of Methantheline can be decreased when used in combination with Donepezil.
MethotrimeprazineThe metabolism of Donepezil can be decreased when combined with Methotrimeprazine.
MethyldopaDonepezil may increase the bradycardic activities of Methyldopa.
MethylprednisoloneThe risk or severity of adverse effects can be increased when Methylprednisolone is combined with Donepezil.
MetipranololDonepezil may increase the bradycardic activities of Metipranolol.
MetixeneThe therapeutic efficacy of Metixene can be decreased when used in combination with Donepezil.
MetoprololDonepezil may increase the bradycardic activities of Metoprolol.
MifepristoneThe metabolism of Donepezil can be decreased when combined with Mifepristone.
MirabegronThe metabolism of Donepezil can be decreased when combined with Mirabegron.
MitotaneThe serum concentration of Donepezil can be decreased when it is combined with Mitotane.
MivacuriumDonepezil may decrease the neuromuscular blocking activities of Mivacurium.
ModafinilThe serum concentration of Donepezil can be decreased when it is combined with Modafinil.
MometasoneThe risk or severity of adverse effects can be increased when Mometasone is combined with Donepezil.
N-butylscopolammonium bromideThe therapeutic efficacy of N-butylscopolammonium bromide can be decreased when used in combination with Donepezil.
NadololDonepezil may increase the bradycardic activities of Nadolol.
NafcillinThe serum concentration of Donepezil can be decreased when it is combined with Nafcillin.
NebivololDonepezil may increase the bradycardic activities of Nebivolol.
NefazodoneThe metabolism of Donepezil can be decreased when combined with Nefazodone.
NelfinavirThe metabolism of Donepezil can be decreased when combined with Nelfinavir.
NetupitantThe serum concentration of Donepezil can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Donepezil can be decreased when combined with Nevirapine.
NicardipineThe metabolism of Donepezil can be decreased when combined with Nicardipine.
NicotineThe risk or severity of adverse effects can be increased when Donepezil is combined with Nicotine.
Nicotine bitartrateThe risk or severity of adverse effects can be increased when Donepezil is combined with Nicotine bitartrate.
NilotinibThe metabolism of Donepezil can be decreased when combined with Nilotinib.
NVA237The therapeutic efficacy of NVA237 can be decreased when used in combination with Donepezil.
OctreotideOctreotide may increase the bradycardic activities of Donepezil.
OlaparibThe metabolism of Donepezil can be decreased when combined with Olaparib.
OmeprazoleThe metabolism of Donepezil can be decreased when combined with Omeprazole.
OrphenadrineThe therapeutic efficacy of Orphenadrine can be decreased when used in combination with Donepezil.
OsimertinibThe serum concentration of Donepezil can be increased when it is combined with Osimertinib.
OxprenololDonepezil may increase the bradycardic activities of Oxprenolol.
OxybutyninThe therapeutic efficacy of Oxybutynin can be decreased when used in combination with Donepezil.
OxyphenoniumThe therapeutic efficacy of Oxyphenonium can be decreased when used in combination with Donepezil.
PalbociclibThe serum concentration of Donepezil can be increased when it is combined with Palbociclib.
PancuroniumThe therapeutic efficacy of Pancuronium can be decreased when used in combination with Donepezil.
PanobinostatThe metabolism of Donepezil can be decreased when combined with Panobinostat.
ParamethasoneThe risk or severity of adverse effects can be increased when Paramethasone is combined with Donepezil.
ParoxetineThe metabolism of Donepezil can be decreased when combined with Paroxetine.
PasireotideDonepezil may increase the bradycardic activities of Pasireotide.
Peginterferon alfa-2bThe serum concentration of Donepezil can be decreased when it is combined with Peginterferon alfa-2b.
PenbutololDonepezil may increase the bradycardic activities of Penbutolol.
PentobarbitalThe metabolism of Donepezil can be increased when combined with Pentobarbital.
PentoliniumThe therapeutic efficacy of Pentolinium can be decreased when used in combination with Donepezil.
PhenobarbitalThe metabolism of Donepezil can be increased when combined with Phenobarbital.
PhenytoinThe metabolism of Donepezil can be increased when combined with Phenytoin.
PilocarpineThe risk or severity of adverse effects can be increased when Donepezil is combined with Pilocarpine.
PindololDonepezil may increase the bradycardic activities of Pindolol.
PipecuroniumThe therapeutic efficacy of Pipecuronium can be decreased when used in combination with Donepezil.
PirenzepineThe therapeutic efficacy of Pirenzepine can be decreased when used in combination with Donepezil.
Poractant alfaDonepezil may increase the bradycardic activities of Poractant alfa.
PosaconazoleThe metabolism of Donepezil can be decreased when combined with Posaconazole.
PractololDonepezil may increase the bradycardic activities of Practolol.
PrednicarbateThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Donepezil.
PrednisoloneThe risk or severity of adverse effects can be increased when Prednisolone is combined with Donepezil.
PrednisoneThe risk or severity of adverse effects can be increased when Prednisone is combined with Donepezil.
PregnenoloneThe risk or severity of adverse effects can be increased when Pregnenolone is combined with Donepezil.
PrimidoneThe metabolism of Donepezil can be increased when combined with Primidone.
ProcyclidineThe therapeutic efficacy of Procyclidine can be decreased when used in combination with Donepezil.
PromazineThe metabolism of Donepezil can be decreased when combined with Promazine.
PropafenoneDonepezil may increase the bradycardic activities of Propafenone.
PropanthelineThe therapeutic efficacy of Propantheline can be decreased when used in combination with Donepezil.
PropranololDonepezil may increase the bradycardic activities of Propranolol.
PyrimethamineThe metabolism of Donepezil can be decreased when combined with Pyrimethamine.
QuinidineThe therapeutic efficacy of Quinidine can be decreased when used in combination with Donepezil.
QuinidineThe metabolism of Donepezil can be decreased when combined with Quinidine.
QuinineThe metabolism of Donepezil can be decreased when combined with Quinine.
RanolazineThe metabolism of Donepezil can be decreased when combined with Ranolazine.
RapacuroniumDonepezil may decrease the neuromuscular blocking activities of Rapacuronium.
RifabutinThe metabolism of Donepezil can be increased when combined with Rifabutin.
RifampicinThe metabolism of Donepezil can be increased when combined with Rifampicin.
RifapentineThe metabolism of Donepezil can be increased when combined with Rifapentine.
RimexoloneThe risk or severity of adverse effects can be increased when Rimexolone is combined with Donepezil.
RitonavirThe metabolism of Donepezil can be decreased when combined with Ritonavir.
RivastigmineDonepezil may increase the bradycardic activities of Rivastigmine.
RolapitantThe metabolism of Donepezil can be decreased when combined with Rolapitant.
RopiniroleThe metabolism of Donepezil can be decreased when combined with Ropinirole.
RuxolitinibRuxolitinib may increase the bradycardic activities of Donepezil.
SaquinavirThe metabolism of Donepezil can be decreased when combined with Saquinavir.
ScopolamineThe therapeutic efficacy of Scopolamine can be decreased when used in combination with Donepezil.
Scopolamine butylbromideThe therapeutic efficacy of Scopolamine butylbromide can be decreased when used in combination with Donepezil.
SecobarbitalThe metabolism of Donepezil can be increased when combined with Secobarbital.
SertralineThe metabolism of Donepezil can be decreased when combined with Sertraline.
SildenafilThe metabolism of Donepezil can be decreased when combined with Sildenafil.
SiltuximabThe serum concentration of Donepezil can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Donepezil can be increased when it is combined with Simeprevir.
SolifenacinThe therapeutic efficacy of Solifenacin can be decreased when used in combination with Donepezil.
SorafenibThe metabolism of Donepezil can be decreased when combined with Sorafenib.
SotalolDonepezil may increase the bradycardic activities of Sotalol.
St. John's WortThe serum concentration of Donepezil can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Donepezil can be increased when it is combined with Stiripentol.
SuccinylcholineThe serum concentration of Succinylcholine can be increased when it is combined with Donepezil.
SufentanilSufentanil may increase the bradycardic activities of Donepezil.
SulfadiazineThe metabolism of Donepezil can be decreased when combined with Sulfadiazine.
SulfamethoxazoleThe metabolism of Donepezil can be decreased when combined with Sulfamethoxazole.
SulfisoxazoleThe metabolism of Donepezil can be decreased when combined with Sulfisoxazole.
TelaprevirThe metabolism of Donepezil can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Donepezil can be decreased when combined with Telithromycin.
TerbinafineThe metabolism of Donepezil can be decreased when combined with Terbinafine.
ThioridazineThe metabolism of Donepezil can be decreased when combined with Thioridazine.
TicagrelorThe metabolism of Donepezil can be decreased when combined with Ticagrelor.
TiclopidineThe metabolism of Donepezil can be decreased when combined with Ticlopidine.
TimololDonepezil may increase the bradycardic activities of Timolol.
TiotropiumThe therapeutic efficacy of Tiotropium can be decreased when used in combination with Donepezil.
TipranavirThe metabolism of Donepezil can be decreased when combined with Tipranavir.
TixocortolThe risk or severity of adverse effects can be increased when Tixocortol is combined with Donepezil.
TizanidineTizanidine may increase the bradycardic activities of Donepezil.
TocilizumabThe serum concentration of Donepezil can be decreased when it is combined with Tocilizumab.
TofacitinibTofacitinib may increase the bradycardic activities of Donepezil.
TolbutamideThe metabolism of Donepezil can be decreased when combined with Tolbutamide.
TolterodineThe therapeutic efficacy of Tolterodine can be decreased when used in combination with Donepezil.
TranylcypromineThe metabolism of Donepezil can be decreased when combined with Tranylcypromine.
TriamcinoloneThe risk or severity of adverse effects can be increased when Triamcinolone is combined with Donepezil.
TrihexyphenidylThe therapeutic efficacy of Trihexyphenidyl can be decreased when used in combination with Donepezil.
TrimethaphanThe therapeutic efficacy of Trimethaphan can be decreased when used in combination with Donepezil.
TrimethoprimThe metabolism of Donepezil can be decreased when combined with Trimethoprim.
TropicamideThe therapeutic efficacy of Tropicamide can be decreased when used in combination with Donepezil.
TrospiumThe therapeutic efficacy of Trospium can be decreased when used in combination with Donepezil.
TubocurarineThe therapeutic efficacy of Tubocurarine can be decreased when used in combination with Donepezil.
UmeclidiniumThe therapeutic efficacy of Umeclidinium can be decreased when used in combination with Donepezil.
Valproic AcidThe metabolism of Donepezil can be decreased when combined with Valproic Acid.
ValsartanThe metabolism of Donepezil can be decreased when combined with Valsartan.
VareniclineThe risk or severity of adverse effects can be increased when Donepezil is combined with Varenicline.
VecuroniumThe therapeutic efficacy of Vecuronium can be decreased when used in combination with Donepezil.
VenlafaxineThe metabolism of Donepezil can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Donepezil can be decreased when combined with Verapamil.
VerapamilDonepezil may increase the bradycardic activities of Verapamil.
VoriconazoleThe metabolism of Donepezil can be decreased when combined with Voriconazole.
ZafirlukastThe metabolism of Donepezil can be decreased when combined with Zafirlukast.
ZiprasidoneThe metabolism of Donepezil can be decreased when combined with Ziprasidone.
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Serine hydrolase activity
Specific Function:
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
Gene Name:
ACHE
Uniprot ID:
P22303
Molecular Weight:
67795.525 Da
References
  1. Davis KL: Alzheimer's disease: seeking new ways to preserve brain function. Interview by Alice V. Luddington. Geriatrics. 1999 Feb;54(2):42-7; quiz 48. [PubMed:10024872 ]
  2. Kryger G, Silman I, Sussman JL: Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure. 1999 Mar 15;7(3):297-307. [PubMed:10368299 ]
  3. Shepherd G, Klein-Schwartz W, Edwards R: Donepezil overdose: a tenfold dosing error. Ann Pharmacother. 1999 Jul-Aug;33(7-8):812-5. [PubMed:10466911 ]
  4. Kosasa T, Kuriya Y, Matsui K, Yamanishi Y: Effect of donepezil hydrochloride (E2020) on basal concentration of extracellular acetylcholine in the hippocampus of rats. Eur J Pharmacol. 1999 Sep 10;380(2-3):101-7. [PubMed:10513568 ]
  5. Jann MW: Rivastigmine, a new-generation cholinesterase inhibitor for the treatment of Alzheimer's disease. Pharmacotherapy. 2000 Jan;20(1):1-12. [PubMed:10641971 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  7. Sugimoto H: Donepezil hydrochloride: a treatment drug for Alzheimer's disease. Chem Rec. 2001;1(1):63-73. [PubMed:11893059 ]
  8. Ki YS, Park EY, Lee HW, Oh MS, Cho YW, Kwon YK, Moon JH, Lee KT: Donepezil, a potent acetylcholinesterase inhibitor, induces caspase-dependent apoptosis in human promyelocytic leukemia HL-60 cells. Biol Pharm Bull. 2010;33(6):1054-9. [PubMed:20522977 ]
  9. Repantis D, Laisney O, Heuser I: Acetylcholinesterase inhibitors and memantine for neuroenhancement in healthy individuals: a systematic review. Pharmacol Res. 2010 Jun;61(6):473-81. doi: 10.1016/j.phrs.2010.02.009. Epub 2010 Mar 1. [PubMed:20193764 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other/unknown
General Function:
Virus receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates...
Gene Name:
HTR2A
Uniprot ID:
P28223
Molecular Weight:
52602.58 Da
References
  1. Hayslett RL, Tizabi Y: Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: implications for Tourette's syndrome. Pharmacol Biochem Behav. 2005 Aug;81(4):879-86. [PubMed:16045972 ]
  2. Hayslett RL, Tizabi Y: Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome. Pharmacol Biochem Behav. 2003 Dec;76(3-4):409-15. [PubMed:14643839 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on September 30, 2016 03:38