You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameDonepezil
Accession NumberDB00843  (APRD00039)
TypeSmall Molecule
GroupsApproved
Description

Donepezil (Aricept), is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer’s disease where it is used to increase cortical acetylcholine. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil’s effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. Donepezil has been tested in other cognitive disorders including Lewy body dementia and Vascular dementia, but it is not currently approved for these indications. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, and Down syndrome.

Structure
Thumb
Synonyms
Domepezil
Donepezil
Donepezil
Donepezilo
Donepezilum
External Identifiers
  • BNAG
  • E 2020
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Accel-donepeziltablet10 mgoralAccel Pharma Inc2014-09-04Not applicableCanada
Accel-donepeziltablet5 mgoralAccel Pharma Inc2014-09-04Not applicableCanada
Act Donepeziltablet5 mgoralActavis Pharma Company2013-12-27Not applicableCanada
Act Donepeziltablet10 mgoralActavis Pharma Company2013-12-27Not applicableCanada
Act Donepezil ODTtablet (orally disintegrating)10 mgoralActavis Pharma Company2013-12-27Not applicableCanada
Act Donepezil ODTtablet (orally disintegrating)5 mgoralActavis Pharma Company2013-12-27Not applicableCanada
Ag-donepeziltablet10 mgoralAngita Pharma Inc.Not applicableNot applicableCanada
Ag-donepeziltablet5 mgoralAngita Pharma Inc.Not applicableNot applicableCanada
Aricepttablet, film coated10 mg/1oralbryant ranch prepack1996-11-252016-04-05Us
Aricepttablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.1996-11-252016-04-05Us
Aricepttablet, film coated10 mg/1oralCardinal Health1996-11-262016-04-05Us
Aricepttablet, film coated23 mg/1oralEisai Inc.2010-07-232016-04-05Us
Aricepttablet, film coated5 mg/1oralCardinal Health1996-11-262016-04-05Us
Aricepttablet, film coated10 mg/1oralEisai Inc.1996-11-252016-04-05Us
Aricepttablet10 mgoralPfizer Canada Inc1997-08-20Not applicableCanada
Aricepttablet, film coated5 mg/1oralEisai Inc.1996-11-252016-04-05Us
Aricepttablet, film coated10 mg/1oralPhysicians Total Care, Inc.2005-05-092016-04-05Us
Aricepttablet5 mgoralPfizer Canada Inc1997-08-20Not applicableCanada
Aricepttablet, film coated5 mg/1oralPhysicians Total Care, Inc.2008-05-092016-04-05Us
Aricept ODTtablet, orally disintegrating10 mg/1oralEisai Inc.2004-10-182016-04-05Us
Aricept ODTtablet, orally disintegrating5 mg/1oralEisai Inc.2004-10-182016-04-05Us
Aricept Rdttablet (orally disintegrating)10 mgoralPfizer Canada Inc2006-01-02Not applicableCanada
Aricept Rdttablet (orally disintegrating)5 mgoralPfizer Canada Inc2006-01-02Not applicableCanada
Auro-donepeziltablet10 mgoralAuro Pharma Inc2013-12-27Not applicableCanada
Auro-donepeziltablet5 mgoralAuro Pharma Inc2013-12-27Not applicableCanada
Bio-donepeziltablet10 mgoralBiomed Pharma2013-12-27Not applicableCanada
Bio-donepeziltablet5 mgoralBiomed Pharma2013-12-27Not applicableCanada
Dom-donepeziltablet5 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-donepeziltablet10 mgoralDominion PharmacalNot applicableNot applicableCanada
Donepeziltablet5 mgoralPro Doc Limitee2013-12-30Not applicableCanada
Donepeziltablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Donepeziltablet10 mgoralPro Doc Limitee2013-12-30Not applicableCanada
Donepeziltablet5 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Donepeziltablet10 mgoralSivem Pharmaceuticals Ulc2014-02-11Not applicableCanada
Donepeziltablet5 mgoralSivem Pharmaceuticals Ulc2014-02-11Not applicableCanada
Donepeziltablet10 mgoralSanis Health IncNot applicableNot applicableCanada
Donepeziltablet5 mgoralSanis Health IncNot applicableNot applicableCanada
Donepezil Hydrochloridetablet, film coated5 mg/1oralContract Pharmacy Services Pa2011-01-312016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralGreenstone LLC1996-11-262017-07-31Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1996-11-262016-04-23Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralCardinal Health1996-11-262016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralGreenstone LLC1996-11-262015-12-29Us
Donepezil Hydrochloridetablet10 mgoralJubilant Generics LimitedNot applicableNot applicableCanada
Donepezil Hydrochloridetablet, film coated10 mg/1oralContract Pharmacy Services Pa2011-01-312016-04-05Us
Donepezil Hydrochloridetablet5 mgoralJubilant Generics LimitedNot applicableNot applicableCanada
Donepezil Hydrochloridetablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1996-11-262016-04-23Us
Donepezil Hydrochloride ODTtablet, orally disintegrating10 mg/1oralGreenstone LLC2004-10-182018-02-01Us
Donepezil Hydrochloride ODTtablet, orally disintegrating5 mg/1oralGreenstone LLC2004-10-182018-07-01Us
Donepezil Hydrochloride Tabletstablet5 mgoralAccord Healthcare Inc2013-12-27Not applicableCanada
Donepezil Hydrochloride Tabletstablet10 mgoralAccord Healthcare Inc2013-12-27Not applicableCanada
Donepezil Hydrochloride Tablets USPtablet10 mgoralDr Reddys Laboratories LtdNot applicableNot applicableCanada
Donepezil Hydrochloride Tablets USPtablet5 mgoralDr Reddys Laboratories LtdNot applicableNot applicableCanada
Ecl-donepeziltablet5 mgoralEcl Pharma Group LtdNot applicableNot applicableCanada
Ecl-donepeziltablet10 mgoralEcl Pharma Group LtdNot applicableNot applicableCanada
Ipg-donepeziltablet10 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Ipg-donepeziltablet5 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Jamp-donepeziltablet10 mgoralJamp Pharma Corporation2013-12-27Not applicableCanada
Jamp-donepeziltablet5 mgoralJamp Pharma Corporation2013-12-27Not applicableCanada
Jamp-donepezil Tabletstablet10 mgoralJamp Pharma Corporation2014-09-26Not applicableCanada
Jamp-donepezil Tabletstablet5 mgoralJamp Pharma Corporation2014-09-26Not applicableCanada
Mar-donepeziltablet10 mgoralMarcan Pharmaceuticals Inc2014-01-06Not applicableCanada
Mar-donepeziltablet5 mgoralMarcan Pharmaceuticals Inc2014-01-06Not applicableCanada
Mint-donepeziltablet10 mgoralMint Pharmaceuticals IncNot applicableNot applicableCanada
Mint-donepeziltablet5 mgoralMint Pharmaceuticals IncNot applicableNot applicableCanada
Mylan-donepeziltablet10 mgoralMylan Pharmaceuticals Ulc2013-12-27Not applicableCanada
Mylan-donepeziltablet5 mgoralMylan Pharmaceuticals Ulc2013-12-27Not applicableCanada
Nat-donepeziltablet10 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada
Nat-donepeziltablet5 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada
PMS-donepeziltablet10 mgoralPharmascience Inc2013-12-27Not applicableCanada
PMS-donepeziltablet5 mgoralPharmascience Inc2013-12-27Not applicableCanada
Priva-donepeziltablet10 mgoralPharmapar IncNot applicableNot applicableCanada
Priva-donepeziltablet5 mgoralPharmapar IncNot applicableNot applicableCanada
Ran-donepeziltablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-12-24Not applicableCanada
Ran-donepeziltablet5 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-12-24Not applicableCanada
Riva-donepeziltablet10 mgoralLaboratoire Riva Inc2013-12-27Not applicableCanada
Riva-donepeziltablet5 mgoralLaboratoire Riva Inc2013-12-27Not applicableCanada
Sandoz Donepeziltablet10 mgoralSandoz Canada Incorporated2013-12-27Not applicableCanada
Sandoz Donepeziltablet5 mgoralSandoz Canada Incorporated2013-12-27Not applicableCanada
Sandoz Donepezil ODTtablet (orally disintegrating)10 mgoralSandoz Canada Incorporated2014-03-19Not applicableCanada
Sandoz Donepezil ODTtablet (orally disintegrating)5 mgoralSandoz Canada Incorporated2014-03-19Not applicableCanada
Septa Donepeziltablet5 mgoralSepta Pharmaceuticals Inc2014-10-30Not applicableCanada
Septa Donepeziltablet10 mgoralSepta Pharmaceuticals Inc2014-10-30Not applicableCanada
Teva-donepeziltablet10 mgoralTeva Canada Limited2013-12-27Not applicableCanada
Teva-donepeziltablet5 mgoralTeva Canada Limited2013-12-27Not applicableCanada
Van-donepeziltablet10 mgoralVanc Pharmaceuticals Inc2015-06-02Not applicableCanada
Van-donepeziltablet5 mgoralVanc Pharmaceuticals Inc2015-06-02Not applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-donepeziltablet10 mgoralApotex Inc2014-12-27Not applicableCanada
Apo-donepeziltablet5 mgoralApotex Inc2013-12-27Not applicableCanada
Donepeziltablet10 mg/1oralCamber Pharmaceuticals, Inc.2015-02-022016-04-05Us
Donepeziltablet5 mg/1oralCamber Pharmaceuticals, Inc.2015-02-022016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralVensun Pharmaceuticals, Inc.2014-12-102016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralAidarex Pharmaceuticals LLC2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralLucid Pharma Llc2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralScie Gen Pharmaceuticals, Inc.2014-10-292016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralJubilant Cadista Pharmaceuticals Inc.2011-05-292016-04-05Us
Donepezil Hydrochloridetablet5 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralVensun Pharmaceuticals, Inc.2014-12-102016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralCardinal Health2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralREMEDYREPACK INC.2015-05-202016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralAmerican Health Packaging2014-06-072016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralPhysicians Total Care, Inc.2010-12-072016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralGolden State Medical Supply, Inc2014-10-292016-04-05Us
Donepezil Hydrochloridetablet, orally disintegrating10 mg/1oralCadila Healthcare Limited2011-05-112016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralAlembic Pharmaceuticals Inc.2016-01-292016-04-05Us
Donepezil Hydrochloridetablet, orally disintegrating5 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2013-03-082016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralMc Kesson Contract Packaging2013-04-102016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralCarilion Materials Management2011-05-282016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralAlembic Pharmaceuticals Inc.2016-01-292016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-05-282016-04-23Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralWest ward Pharmaceutical Corp2011-05-282016-04-23Us
Donepezil Hydrochloridetablet, extended release23 mg/1oralAv Kare, Inc.2015-03-112016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralLucid Pharma Llc2011-05-312016-04-05Us
Donepezil Hydrochloridetablet23 mg/1oralPar Pharmaceutical, Inc.2013-09-152016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralJubilant Cadista Pharmaceuticals Inc.2011-05-292016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralbryant ranch prepack2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralCardinal Health2011-06-072016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralREMEDYREPACK INC.2015-05-202016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralAmerican Health Packaging2014-06-072016-04-05Us
Donepezil Hydrochloridetablet, orally disintegrating5 mg/1oralCadila Healthcare Limited2011-05-112016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralAlembic Pharmaceuticals Limited2016-01-292016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralMajor Pharmaceuticals2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-05-312016-04-23Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralREMEDYREPACK INC.2013-07-252016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralHikma Pharmaceutical2011-05-282016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralRanbaxy Pharmaceuticals Inc.2010-11-292016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralCardinal Health2011-06-072016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralREMEDYREPACK INC.2014-12-182016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralContract Pharmacy Services Pa2011-05-282016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralWockhardt USA LLC.2011-05-282016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralAlembic Pharmaceuticals Limited2016-01-292016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralMajor Pharmaceuticals2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-05-312016-04-23Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralRebel Distributors Corp2011-05-282016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralHikma Pharmaceutical2011-05-282016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralRanbaxy Pharmaceuticals Inc.2010-11-292016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralCardinal Health2011-11-012016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralSt Marys Medical Park Pharmacy2014-05-222016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralContract Pharmacy Services Pa2011-05-282016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralWockhardt USA LLC.2011-05-282016-04-05Us
Donepezil Hydrochloridetablet, orally disintegrating10 mg/1oralZydus Pharmaceuticals (USA) Inc.2011-05-112016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralBiomes Pharmaceuticals LLC2016-02-252016-04-05Us
Donepezil Hydrochloridetablet, orally disintegrating10 mg/1oralSandoz Inc2011-05-102016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralMylan Pharmaceuticals Inc.2011-05-312016-04-23Us
Donepezil Hydrochloridetablet, film coated23 mg/1oralMacleods Pharmaceuticals Limited2014-01-232016-04-05Us
Donepezil Hydrochloridetablet, extended release23 mg/1oralT Wi Pharmaceuticals, Inc.2015-03-012016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralREMEDYREPACK INC.2013-05-242016-04-05Us
Donepezil Hydrochloridetablet, orally disintegrating5 mg/1oralZydus Pharmaceuticals (USA) Inc.2011-05-112016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralBiomes Pharmaceuticals LLC2016-02-252016-04-05Us
Donepezil Hydrochloridetablet, orally disintegrating5 mg/1oralSandoz Inc2011-05-102016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralMylan Pharmaceuticals Inc.2011-05-312016-04-23Us
Donepezil Hydrochloridetablet, orally disintegrating10 mg/1oralMacleods Pharmaceuticals Limited2012-12-142016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralINDICUS PHARMA LLC2011-06-152016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralREMEDYREPACK INC.2013-05-222016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralActavis Inc.2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralWockhardt Limited2011-05-282016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralProficient Rx LP2011-05-292016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralDr. Reddys Laboratories Limited2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralSt Marys Medical Park Pharmacy2014-05-222016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralAurobindo Pharma Limited2011-05-312016-04-05Us
Donepezil Hydrochloridetablet10 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2011-05-312016-04-05Us
Donepezil Hydrochloridetablet10 mg/1oralSandoz Inc2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated23 mg/1oralMylan Pharmaceuticals Inc.2015-12-112016-04-23Us
Donepezil Hydrochloridetablet, orally disintegrating5 mg/1oralMacleods Pharmaceuticals Limited2012-12-142016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralINDICUS PHARMA LLC2011-06-152016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralUnit Dose Services2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralSolco Healthcare US, LLC2011-11-012016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralWockhardt Limited2011-05-282016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralSun Pharmaceutical Industries Limited2011-06-012016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralDr. Reddys Laboratories Limited2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralAmerican Health Packaging2015-07-152016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralAurobindo Pharma Limited2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2013-03-082016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralPreferred Pharmaceuticals, Inc.2011-05-312015-10-31Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralZydus Pharmaceuticals (USA) Inc.2011-05-252016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.2012-08-172016-04-05Us
Donepezil Hydrochloridetablet5 mg/1oralSandoz Inc2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated23 mg/1oralActavis Pharma, Inc.2015-12-222016-04-23Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralMacleods Pharmaceuticals Limited2012-08-172016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralTorrent Pharmaceuticals Limited2011-05-282016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralUnit Dose Services2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralSolco Healthcare US, LLC2011-11-012016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralCardinal Health2014-06-072016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralSun Pharmaceutical Industries Limited2011-06-012016-04-05Us
Donepezil Hydrochloridetablet, film coated23 mg/1oralDr. Reddys Laboratories Limited2013-07-262016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralAmerican Health Packaging2015-07-152016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralCadila Healthcare Limited2011-05-252016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2013-03-082016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralTeva Pharmaceuticals USA Inc2011-05-312015-10-31Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralZydus Pharmaceuticals (USA) Inc.2011-05-252016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralCitron Pharma LLC2011-05-312016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralMacleods Pharmaceuticals Limited2012-08-172016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralTorrent Pharmaceuticals Limited2011-05-282016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralScie Gen Pharmaceuticals, Inc.2014-10-292016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.2011-06-012016-04-05Us
Donepezil Hydrochloridetablet, film coated23 mg/1oralSun Pharmaceutical Industries Limited2015-06-172016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralPhysicians Total Care, Inc.2010-12-272016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralGolden State Medical Supply, Inc2014-10-292016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralCadila Healthcare Limited2011-05-252016-04-05Us
Donepezil Hydrochloridetablet, orally disintegrating10 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2013-03-082016-04-05Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralMc Kesson Contract Packaging2013-04-102016-04-05Us
Donepezil Hydrochloridetablet23 mg/1oralLupin Pharmaceuticals, Inc.2015-12-212016-04-05Us
Donepezil Hydrochloridetablet, film coated5 mg/1oralCitron Pharma LLC2011-05-312016-04-05Us
Donepezil Hydrochloridetablet5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-05-282016-04-23Us
Donepezil Hydrochloridetablet, film coated10 mg/1oralWest ward Pharmaceutical Corp2011-05-282016-04-23Us
Donepezil Hydrochloride 10 mgtablet, film coated10 mg/1oralMajor Pharmaceuticals2014-06-152016-04-05Us
Donepezil Hydrochloride 10 mgtablet, film coated10 mg/1oralCardinal Health2014-06-152016-04-05Us
Donepezil Hydrochloride 10mgtablet, film coated10 mg/1oralBionpharma Inc.2015-07-012016-04-05Us
Donepezil Hydrochloride 5 mgtablet, film coated5 mg/1oralMajor Pharmaceuticals2014-06-152016-04-05Us
Donepezil Hydrochloride 5 mgtablet, film coated10 mg/1oralAlembic Pharmaceuticals Limited2013-02-192016-04-05Us
Donepezil Hydrochloride 5 mgtablet, film coated5 mg/1oralAlembic Pharmaceuticals Limited2013-03-042016-04-05Us
Donepezil Hydrochloride 5 mgtablet, film coated5 mg/1oralCardinal Health2014-06-152016-04-05Us
Donepezil Hyrochloride 5mgtablet, film coated5 mg/1oralBionpharma Inc.2015-07-012016-04-05Us
Over the Counter ProductsNot Available
International Brands
NameCompany
AlzepilEgis
DaviaTerapia
DepzilPsyco Remedies
DoneceptActavis
DonecilABL Pharma
DonepAlkem
DonepexSchafer
DonesynSynthon
DopezilMedis
EranzWyeth
Memac Pfizer
Nomi-NoxJohnson
PezaleSandoz
RedumasTeva
ZolpezilActavis
Brand mixtures
NameLabellerIngredients
NamzaricForest Laboratories, Inc.
Salts
Name/CASStructureProperties
Donepezil hydrochloride
ThumbNot applicableDBSALT000938
Categories
UNII8SSC91326P
CAS number120014-06-4
WeightAverage: 379.492
Monoisotopic: 379.214743799
Chemical FormulaC24H29NO3
InChI KeyInChIKey=ADEBPBSSDYVVLD-UHFFFAOYSA-N
InChI
InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
IUPAC Name
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
SMILES
COC1=C(OC)C=C2C(=O)C(CC3CCN(CC4=CC=CC=C4)CC3)CC2=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as n-benzylpiperidines. These are heterocyclic Compounds containing a piperidine ring conjugated to a benzyl group through one nitrogen ring atom.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPiperidines
Sub ClassBenzylpiperidines
Direct ParentN-benzylpiperidines
Alternative Parents
Substituents
  • N-benzylpiperidine
  • Indanone
  • Indane
  • Aryl alkyl ketone
  • Aryl ketone
  • Phenylmethylamine
  • Benzylamine
  • Anisole
  • Aralkylamine
  • Alkyl aryl ether
  • Benzenoid
  • Monocyclic benzene moiety
  • Tertiary aliphatic amine
  • Tertiary amine
  • Ketone
  • Azacycle
  • Ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the palliative treatment of mild to moderate dementia of the Alzheimer's type.
PharmacodynamicsDonepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. An early pathophysiological feature of Alzheimer's disease that is associated with memory loss and cognitive deficits is a deficiency of acetylcholine as a result of selective loss of cholinergic neurons in the cerebral cortex, nucleus basalis, and hippocampus. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil's effect may lessen as the disease progresses and fewer cholinergic neurons remain functionally intact. There is no evidence that donepezil alters the course of the underlying dementing process.
Mechanism of actionDonepezil is a piperidine derivative that is a centerally active, reversible inhibitor of acetylcholinesterase. This drug is structurally unrelated to other anticholinesterase agents. Donepezil's proposed mechanism of action involves the reversible inhibition of cholinesterases (eg. acetylcholinesterase), which prevents the hydrolysis of acetycholine, and leads to an increased concentration of acetylcholine at cholinergic synapses. Evidence suggests that the anticholinesterase activity of donepezil is relatively specific for acetylcholinesterase in the brain.
Related Articles
AbsorptionDonepezil is well absorbed with a relative oral bioavailability of 100% and reaches peak plasma concentrations in 3 to 4 hours.
Volume of distribution
  • 12 L/kg
Protein binding96%
Metabolism

Donepezil is metabolized by CYP 450 isoenzymes 2D6 and 3A4 in the liver and also undergoes glucuronidation. The main metabolite, 6-O-desmethyl donepezil, has been reported to inhibit AChE to the same extent as donepezil in vitro.

SubstrateEnzymesProduct
Donepezil
5-O-DesmethyldonepezilDetails
Donepezil
6-O-DesmethyldonepezilDetails
Donepezil
Donepezil metabolite M4Details
Donepezil
Not Available
Donepezil metabolite M3Details
Donepezil
Not Available
Donepezil metabolite M5Details
Donepezil
Not Available
Donepezil metabolite M6Details
Donepezil metabolite M3
Not Available
Donepezil metabolite M7Details
Donepezil metabolite M7
Not Available
Donepezil metabolite M7 sulfateDetails
Donepezil metabolite M4
Not Available
Donepezil metabolite M8Details
5-O-Desmethyldonepezil
Not Available
Donepezil metabolite M9Details
6-O-Desmethyldonepezil
Not Available
Donepezil metabolite M9Details
Donepezil metabolite M9
Not Available
Donepezil metabolite M10Details
5-O-Desmethyldonepezil
Not Available
Donepezil metabolite M7Details
Donepezil metabolite M7
Not Available
Donepezil metabolite M10Details
6-O-Desmethyldonepezil
Not Available
Donepezil metabolite M11Details
5-O-Desmethyldonepezil
Not Available
Donepezil metabolite M12Details
Donepezil metabolite M9
Not Available
Donepezil metabolite M13Details
Donepezil metabolite M9
Not Available
Donepezil metabolite M14Details
Route of eliminationDonepezil is both excreted in the urine intact and extensively metabolized to four major metabolites, two of which are known to be active, and a number of minor metabolites, not all of which have been identified.
Half life70 hours
Clearance
  • apparent plasma cl=0.13 L/hr/kg
ToxicitySymptoms of overdose include severe nausea, vomiting, salivation, sweating, bradycardia, hypotension, respiratory depression, collapse and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9966
Blood Brain Barrier+0.9953
Caco-2 permeable+0.7742
P-glycoprotein substrateSubstrate0.7721
P-glycoprotein inhibitor IInhibitor0.7641
P-glycoprotein inhibitor IIInhibitor0.8202
Renal organic cation transporterInhibitor0.7696
CYP450 2C9 substrateNon-substrate0.8465
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateSubstrate0.7202
CYP450 1A2 substrateInhibitor0.5072
CYP450 2C9 inhibitorNon-inhibitor0.8189
CYP450 2D6 inhibitorInhibitor0.8684
CYP450 2C19 inhibitorNon-inhibitor0.8356
CYP450 3A4 inhibitorNon-inhibitor0.7411
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.6138
Ames testNon AMES toxic0.6441
CarcinogenicityNon-carcinogens0.9528
BiodegradationNot ready biodegradable0.9145
Rat acute toxicity3.0123 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.5386
hERG inhibition (predictor II)Inhibitor0.8095
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Eisai inc
  • Mutual pharmaceutical co inc
  • Teva pharmaceuticals usa inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral10 mg
Tabletoral5 mg
Tablet (orally disintegrating)oral10 mg
Tablet (orally disintegrating)oral5 mg
Tabletoral10 mg/1
Tabletoral23 mg/1
Tabletoral5 mg/1
Tablet, extended releaseoral23 mg/1
Tablet, film coatedoral10 mg/1
Tablet, film coatedoral23 mg/1
Tablet, film coatedoral5 mg/1
Tablet, orally disintegratingoral10 mg/1
Tablet, orally disintegratingoral5 mg/1
Capsuleoral
Prices
Unit descriptionCostUnit
Aricept ODT 30 5 mg Dispersible Tablet Box272.99USD box
Aricept 10 mg tablet10.93USD tablet
Aricept 5 mg tablet9.78USD tablet
Aricept odt 10 mg tablet8.03USD tablet
Aricept odt 5 mg tablet8.03USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA1338808 No1996-12-242013-12-24Canada
CA2252806 No2005-11-222017-06-06Canada
US4895841 No1993-11-252010-11-25Us
US5061703 Yes1995-10-112015-10-11Us
US7727548 No2002-06-232022-06-23Us
US7727552 No1998-03-262018-03-26Us
US8039009 Yes2009-09-242029-09-24Us
US8058291 No2009-12-052029-12-05Us
US8168209 Yes2006-05-222026-05-22Us
US8173708 Yes2006-05-222026-05-22Us
US8283379 Yes2006-05-222026-05-22Us
US8293794 No2005-11-222025-11-22Us
US8329752 Yes2006-05-222026-05-22Us
US8338485 No2005-11-222025-11-22Us
US8338486 No2005-11-222025-11-22Us
US8362085 Yes2006-05-222026-05-22Us
US8481565 No2006-10-042026-10-04Us
US8580858 No2005-11-222025-11-22Us
US8598233 Yes2006-05-222026-05-22Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point206.72 °CNot Available
water solubility2.931 mg/LNot Available
logP3.6Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0045 mg/mLALOGPS
logP4.14ALOGPS
logP4.21ChemAxon
logS-4.9ALOGPS
pKa (Strongest Acidic)17.02ChemAxon
pKa (Strongest Basic)8.62ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area38.77 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity112.11 m3·mol-1ChemAxon
Polarizability44.34 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Akio Imai, Hideaki Watanabe, Takashi Kajima, Yasushi Ishihama, Akiyo Ohtsuka, Tomohide Tanaka, Yukio Narabu, “Polymorphs of donepezil hydrochloride and process for production.” U.S. Patent US5985864, issued December, 1988.

US5985864
General References
  1. Xiong G, Doraiswamy PM: Combination drug therapy for Alzheimer's disease: what is evidence-based, and what is not? Geriatrics. 2005 Jun;60(6):22-6. [PubMed:15948662 ]
  2. Yesavage JA, Mumenthaler MS, Taylor JL, Friedman L, O'Hara R, Sheikh J, Tinklenberg J, Whitehouse PJ: Donepezil and flight simulator performance: effects on retention of complex skills. Neurology. 2002 Jul 9;59(1):123-5. [PubMed:12105320 ]
  3. Sugimoto H: Donepezil hydrochloride: a treatment drug for Alzheimer's disease. Chem Rec. 2001;1(1):63-73. [PubMed:11893059 ]
External Links
ATC CodesN06DA02N06DA52N06DA53
AHFS Codes
  • 12:04.00
PDB Entries
FDA labelDownload (303 KB)
MSDSDownload (58.2 KB)
Interactions
Drug Interactions
Drug
AcepromazineDonepezil may increase the central neurotoxic activities of Acepromazine.
AcetophenazineDonepezil may increase the central neurotoxic activities of Acetophenazine.
AcetylcholineThe risk or severity of adverse effects can be increased when Donepezil is combined with Acetylcholine.
AmisulprideDonepezil may increase the central neurotoxic activities of Amisulpride.
AripiprazoleDonepezil may increase the central neurotoxic activities of Aripiprazole.
Atracurium besylateDonepezil may decrease the neuromuscular blocking activities of Atracurium besylate.
BenzquinamideDonepezil may increase the central neurotoxic activities of Benzquinamide.
BretyliumBretylium may increase the bradycardic activities of Donepezil.
CarbacholThe risk or severity of adverse effects can be increased when Donepezil is combined with Carbachol.
CarphenazineDonepezil may increase the central neurotoxic activities of Carphenazine.
CeritinibDonepezil may increase the bradycardic activities of Ceritinib.
ChlormezanoneDonepezil may increase the central neurotoxic activities of Chlormezanone.
ChlorpromazineDonepezil may increase the central neurotoxic activities of Chlorpromazine.
ChlorprothixeneDonepezil may increase the central neurotoxic activities of Chlorprothixene.
ClozapineDonepezil may increase the central neurotoxic activities of Clozapine.
DipyridamoleThe therapeutic efficacy of Donepezil can be decreased when used in combination with Dipyridamole.
DroperidolDonepezil may increase the central neurotoxic activities of Droperidol.
EsmololEsmolol may increase the bradycardic activities of Donepezil.
FencamfamineDonepezil may increase the central neurotoxic activities of Fencamfamine.
FludrocortisoneThe risk or severity of adverse effects can be increased when Fludrocortisone is combined with Donepezil.
FlupentixolDonepezil may increase the central neurotoxic activities of Flupentixol.
FluphenazineDonepezil may increase the central neurotoxic activities of Fluphenazine.
FluspirileneDonepezil may increase the central neurotoxic activities of Fluspirilene.
HaloperidolDonepezil may increase the central neurotoxic activities of Haloperidol.
IvabradineDonepezil may increase the bradycardic activities of Ivabradine.
LacosamideDonepezil may increase the atrioventricular blocking (AV block) activities of Lacosamide.
LoxapineDonepezil may increase the central neurotoxic activities of Loxapine.
MesoridazineDonepezil may increase the central neurotoxic activities of Mesoridazine.
MethotrimeprazineDonepezil may increase the central neurotoxic activities of Methotrimeprazine.
MolindoneDonepezil may increase the central neurotoxic activities of Molindone.
NadololDonepezil may increase the bradycardic activities of Nadolol.
OctreotideOctreotide may increase the bradycardic activities of Donepezil.
OlanzapineDonepezil may increase the central neurotoxic activities of Olanzapine.
OndansetronDonepezil may increase the central neurotoxic activities of Ondansetron.
PaliperidoneDonepezil may increase the central neurotoxic activities of Paliperidone.
PerphenazineDonepezil may increase the central neurotoxic activities of Perphenazine.
PimozideDonepezil may increase the central neurotoxic activities of Pimozide.
PiperacetazineDonepezil may increase the central neurotoxic activities of Piperacetazine.
ProchlorperazineDonepezil may increase the central neurotoxic activities of Prochlorperazine.
ProcyclidineThe therapeutic efficacy of Procyclidine can be decreased when used in combination with Donepezil.
PromazineDonepezil may increase the central neurotoxic activities of Promazine.
QuetiapineDonepezil may increase the central neurotoxic activities of Quetiapine.
RemoxiprideDonepezil may increase the central neurotoxic activities of Remoxipride.
ReserpineDonepezil may increase the central neurotoxic activities of Reserpine.
RisperidoneDonepezil may increase the central neurotoxic activities of Risperidone.
RuxolitinibRuxolitinib may increase the bradycardic activities of Donepezil.
SertindoleDonepezil may increase the central neurotoxic activities of Sertindole.
SuccinylcholineThe serum concentration of Succinylcholine can be increased when it is combined with Donepezil.
SulpirideDonepezil may increase the central neurotoxic activities of Sulpiride.
ThioridazineDonepezil may increase the central neurotoxic activities of Thioridazine.
ThiothixeneDonepezil may increase the central neurotoxic activities of Thiothixene.
TofacitinibTofacitinib may increase the bradycardic activities of Donepezil.
TrifluoperazineDonepezil may increase the central neurotoxic activities of Trifluoperazine.
TriflupromazineDonepezil may increase the central neurotoxic activities of Triflupromazine.
ZiprasidoneDonepezil may increase the central neurotoxic activities of Ziprasidone.
ZuclopenthixolDonepezil may increase the central neurotoxic activities of Zuclopenthixol.
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Serine hydrolase activity
Specific Function:
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
Gene Name:
ACHE
Uniprot ID:
P22303
Molecular Weight:
67795.525 Da
References
  1. Davis KL: Alzheimer's disease: seeking new ways to preserve brain function. Interview by Alice V. Luddington. Geriatrics. 1999 Feb;54(2):42-7; quiz 48. [PubMed:10024872 ]
  2. Kryger G, Silman I, Sussman JL: Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure. 1999 Mar 15;7(3):297-307. [PubMed:10368299 ]
  3. Shepherd G, Klein-Schwartz W, Edwards R: Donepezil overdose: a tenfold dosing error. Ann Pharmacother. 1999 Jul-Aug;33(7-8):812-5. [PubMed:10466911 ]
  4. Kosasa T, Kuriya Y, Matsui K, Yamanishi Y: Effect of donepezil hydrochloride (E2020) on basal concentration of extracellular acetylcholine in the hippocampus of rats. Eur J Pharmacol. 1999 Sep 10;380(2-3):101-7. [PubMed:10513568 ]
  5. Jann MW: Rivastigmine, a new-generation cholinesterase inhibitor for the treatment of Alzheimer's disease. Pharmacotherapy. 2000 Jan;20(1):1-12. [PubMed:10641971 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  7. Sugimoto H: Donepezil hydrochloride: a treatment drug for Alzheimer's disease. Chem Rec. 2001;1(1):63-73. [PubMed:11893059 ]
  8. Ki YS, Park EY, Lee HW, Oh MS, Cho YW, Kwon YK, Moon JH, Lee KT: Donepezil, a potent acetylcholinesterase inhibitor, induces caspase-dependent apoptosis in human promyelocytic leukemia HL-60 cells. Biol Pharm Bull. 2010;33(6):1054-9. [PubMed:20522977 ]
  9. Repantis D, Laisney O, Heuser I: Acetylcholinesterase inhibitors and memantine for neuroenhancement in healthy individuals: a systematic review. Pharmacol Res. 2010 Jun;61(6):473-81. doi: 10.1016/j.phrs.2010.02.009. Epub 2010 Mar 1. [PubMed:20193764 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other/unknown
General Function:
Virus receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates...
Gene Name:
HTR2A
Uniprot ID:
P28223
Molecular Weight:
52602.58 Da
References
  1. Hayslett RL, Tizabi Y: Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: implications for Tourette's syndrome. Pharmacol Biochem Behav. 2005 Aug;81(4):879-86. [PubMed:16045972 ]
  2. Hayslett RL, Tizabi Y: Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome. Pharmacol Biochem Behav. 2003 Dec;76(3-4):409-15. [PubMed:14643839 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on April 30, 2016 03:10