Adrenergic agonists suppress the proliferation of microglia through beta 2-adrenergic receptor.

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Fujita H, Tanaka J, Maeda N, Sakanaka M

Adrenergic agonists suppress the proliferation of microglia through beta 2-adrenergic receptor.

Neurosci Lett. 1998 Feb 6;242(1):37-40.

PubMed ID

9509999 [ View in PubMed

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Abstract

The effects of several cyclic adenosine monophosphate (cAMP)-elevating agents on the proliferation of cultured rat microglia were investigated by immunocytochemical staining with an antibody against proliferating cell nuclear antigen (PCNA). Epinephrine, isoproterenol, forskolin and 8Br-cAMP suppressed the microglial proliferation. A beta2-selective agonist terbutaline but not a beta1-selective agonist dobutamine mimicked the effect of the above cAMP-elevating agents. Furthermore, a non-selective beta-receptor antagonist oxprenolol and a beta2-selective antagonist acebutalol, but not a beta1-selective antagonist butoxamine, counteracted the suppressive effects of the beta-agonists on microglial proliferation. These findings suggest that the beta-agonists suppress the proliferation of microglia by elevating intracellular cAMP level through an action on beta2-adrenergic receptor.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Oxprenolol	Beta-2 adrenergic receptor	Protein	Humans	Unknown	Antagonist	Details