Zonisamide has beneficial effects on Parkinson's disease patients.
Article Details
- CitationCopy to clipboard
Murata M, Horiuchi E, Kanazawa I
Zonisamide has beneficial effects on Parkinson's disease patients.
Neurosci Res. 2001 Dec;41(4):397-9.
- PubMed ID
- 11755227 [ View in PubMed]
- Abstract
Zonisamide (ZNS) is a generally well tolerated anticonvulsant that has beneficial effects on Parkinson's disease (PD). ZNS (300 mg/day) given to a patient with PD who incidentally had convulsive attacks, ameliorated the attacks and, surprisingly, his parkinsonian symptoms. We, therefore, carried out an open trial of ZNS on nine patients with PD. Patients were given 50-200 mg/day ZNS in addition to their anti-PD drugs. Seven clearly showed lessening of symptoms, especially wearing-off. We speculate that long lasting activation of dopamine synthesis by ZNS ameliorates parkinsonian symptoms, in particular wearing-off.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Zonisamide Amine oxidase [flavin-containing] B Protein Humans UnknownInhibitorDetails