Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4).
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Wang Y, Zhang Y, Yang X, Han W, Liu Y, Xu Q, Zhao R, Di C, Song Q, Ma D
Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4).
Life Sci. 2006 Jan 2;78(6):614-21. Epub 2005 Aug 30.
- PubMed ID
- 16137713 [ View in PubMed]
- Abstract
Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells could be desensitized by TARC/CCL17 and markedly inhibited by PTX. CKLF1 induced a calcium flux in CCR4-transfected cells and fully desensitized a subsequent response to TARC/CCL17, and TARC/CCL17 could partly desensitize the response to CKLF1. CKLF1 caused significant receptor internalization in pCCR4-EGFP transfected cells. Taken together, CKLF1 is a novel functional ligand for CCR4.