C-C chemokine receptor type 4
Details
- Name
- C-C chemokine receptor type 4
- Synonyms
- C-C CKR-4
- CMKBR4
- K5-5
- Gene Name
- CCR4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052177|C-C chemokine receptor type 4 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
- Number of residues
- 360
- Molecular Weight
- 41402.385
- Theoretical pI
- Not Available
- GO Classification
- FunctionsC-C chemokine binding / C-C chemokine receptor activity / chemokine binding / chemokine receptor activityProcessescalcium-mediated signaling / cell chemotaxis / chemotaxis / G protein-coupled receptor signaling pathway / homeostasis of number of cells / immune response / inflammatory response / neuron migration / positive regulation of cytosolic calcium ion concentration / positive regulation of positive chemotaxis / response to antibiotic / response to bacterium / response to radiation / tolerance inductionComponentsexternal side of plasma membrane / integral component of plasma membrane / neuronal cell body / plasma membrane
- General Function
- High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
- Specific Function
- C-c chemokine binding
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 40-67 78-98 112-133 151-175 207-226 243-267 285-308
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052178|C-C chemokine receptor type 4 (CCR4) ATGAACCCCACGGATATAGCAGACACCACCCTCGATGAAAGCATATACAGCAATTACTAT CTGTATGAAAGTATCCCCAAGCCTTGCACCAAAGAAGGCATCAAGGCATTTGGGGAGCTC TTCCTGCCCCCACTGTATTCCTTGGTTTTTGTATTTGGTCTGCTTGGAAATTCTGTGGTG GTTCTGGTCCTGTTCAAATACAAGCGGCTCAGGTCCATGACTGATGTGTACCTGCTCAAC CTTGCCATCTCGGATCTGCTCTTCGTGTTTTCCCTCCCTTTTTGGGGCTACTATGCAGCA GACCAGTGGGTTTTTGGGCTAGGTCTGTGCAAGATGATTTCCTGGATGTACTTGGTGGGC TTTTACAGTGGCATATTCTTTGTCATGCTCATGAGCATTGATAGATACCTGGCAATTGTG CACGCGGTGTTTTCCTTGAGGGCAAGGACCTTGACTTATGGGGTCATCACCAGTTTGGCT ACATGGTCAGTGGCTGTGTTCGCCTCCCTTCCTGGCTTTCTGTTCAGCACTTGTTATACT GAGCGCAACCATACCTACTGCAAAACCAAGTACTCTCTCAACTCCACGACGTGGAAGGTT CTCAGCTCCCTGGAAATCAACATTCTCGGATTGGTGATCCCCTTAGGGATCATGCTGTTT TGCTACTCCATGATCATCAGGACCTTGCAGCATTGTAAAAATGAGAAGAAGAACAAGGCG GTGAAGATGATCTTTGCCGTGGTGGTCCTCTTCCTTGGGTTCTGGACACCTTACAACATA GTGCTCTTCCTAGAGACCCTGGTGGAGCTAGAAGTCCTTCAGGACTGCACCTTTGAAAGA TACTTGGACTATGCCATCCAGGCCACAGAAACTCTGGCTTTTGTTCACTGCTGCCTTAAT CCCATCATCTACTTTTTTCTGGGGGAGAAATTTCGCAAGTACATCCTACAGCTCTTCAAA ACCTGCAGGGGCCTTTTTGTGCTCTGCCAATACTGTGGGCTCCTCCAAATTTACTCTGCT GACACCCCCAGCTCATCTTACACGCAGTCCACCATGGATCATGATCTCCATGATGCTCTG TAG
- Chromosome Location
- 3
- Locus
- 3p22.3
- External Identifiers
Resource Link UniProtKB ID P51679 UniProtKB Entry Name CCR4_HUMAN HGNC ID HGNC:1605 - General References
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