Selectivity in the binding of psychotropic drugs to the variants of alpha-1 acid glycoprotein.
Article Details
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Eap CB, Cuendet C, Baumann P
Selectivity in the binding of psychotropic drugs to the variants of alpha-1 acid glycoprotein.
Naunyn Schmiedebergs Arch Pharmacol. 1988 Feb;337(2):220-4.
- PubMed ID
- 3368020 [ View in PubMed]
- Abstract
The S- and F-forms of alpha-1 acid glycoprotein (AAG) variants have been isolated by isoelectric focusing with immobilines from commercially available AAG. In equilibrium dialysis experiments using a multicompartmental system, a higher affinity for various basic drugs has been found with S- in comparison with F-AAG: Amitriptyline, nortriptyline, imipramine, desipramine, trimipramine, methadone, thioridazine, clomipramine, desmethylclomipramine, and maprotiline. The selectivity (binding to S- vs. F-AAG) is the most pronounced for methadone and the lowest for thioridazine, while it is absent for the acidic drug mephenytoin.
DrugBank Data that Cites this Article
- Drug Carriers
Drug Carrier Kind Organism Pharmacological Action Actions Maprotiline Alpha-1-acid glycoprotein 1 Protein Humans NoNot Available Details