Isolation of a family of organic anion transporters from human liver and kidney.
Article Details
- CitationCopy to clipboard
Sun W, Wu RR, van Poelje PD, Erion MD
Isolation of a family of organic anion transporters from human liver and kidney.
Biochem Biophys Res Commun. 2001 May 4;283(2):417-22.
- PubMed ID
- 11327718 [ View in PubMed]
- Abstract
Five distinct organic anion transporter cDNAs, hOAT1-5, were isolated from human liver and kidney. hOAT1, 2, and 3 are homologous to their respective rat orthologues OAT1-3, whereas hOAT4 and 5 are novel clones that have not been identified in other species. hOAT1- and hOAT3-transfected cells showed uptake of p-aminohippurate and fluorescein. Cells expressing hOAT2 showed uptake of p-aminohippurate, methotrexate, cAMP, and alpha-ketoglutarate. Northern blot analysis indicated differential tissue distribution for the transporter transcripts. These results indicate the existence of a family of organic anion transporting proteins in humans distinct from the oatp-like family of transporters.
DrugBank Data that Cites this Article
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Aminohippuric acid Solute carrier family 22 member 7 Protein Humans UnknownSubstrateDetails Cyclic adenosine monophosphate Solute carrier family 22 member 7 Protein Humans UnknownSubstrateDetails Methotrexate Solute carrier family 22 member 7 Protein Humans UnknownSubstrateDetails - Polypeptides
Name UniProt ID Solute carrier family 22 member 7 Q9Y694 Details Solute carrier family 22 member 10 Q63ZE4 Details