Interaction of cephalosporins with penicillin-binding proteins of methicillin-resistant Staphylococcus aureus.
Article Details
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Truesdell SE, Zurenko GE, Laborde AL
Interaction of cephalosporins with penicillin-binding proteins of methicillin-resistant Staphylococcus aureus.
J Antimicrob Chemother. 1989 Apr;23 Suppl D:13-9.
- PubMed ID
- 2722720 [ View in PubMed]
- Abstract
The binding affinity of cefmetazole for penicillin binding proteins (PBPs) of methicillin resistant Staphylococcus aureus (MRSA) was compared with the affinities of cefazolin, cefotetan, and cefoxitin for these same sites. Overall, cefmetazole was found to have comparable or higher affinity for PBP1, PBP2, and PBP3 than cefoxitin or cefotetan; its affinity for these PBPs is lower than that of cefazolin. Interestingly, the antibiotic showed a somewhat greater affinity for PBP2' (PBP2a) than cefazolin, cefotetan, and cefoxitin. These results suggest that the somewhat lower MICs detected with cefmetazole for MRSA may be a consequence of the interaction of the antibiotic with PBP2'.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Cefacetrile Penicillin-binding protein 1A Protein Escherichia coli (strain K12) YesInhibitorDetails Cefacetrile Penicillin-binding protein 1B Protein Escherichia coli (strain K12) YesInhibitorDetails Cefazolin Penicillin-binding protein 1A Protein Escherichia coli (strain K12) YesInhibitorDetails Cefazolin Penicillin-binding protein 1B Protein Escherichia coli (strain K12) YesInhibitorDetails Cefazolin Penicillin-binding protein 1C Protein Escherichia coli (strain K12) YesInhibitorDetails Cefazolin Penicillin-binding protein 2 Protein Escherichia coli (strain K12) YesInhibitorDetails Cefazolin Peptidoglycan synthase FtsI Protein Escherichia coli (strain K12) YesInhibitorDetails