Privileged structures: a useful concept for the rational design of new lead drug candidates.
Article Details
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Duarte CD, Barreiro EJ, Fraga CA
Privileged structures: a useful concept for the rational design of new lead drug candidates.
Mini Rev Med Chem. 2007 Nov;7(11):1108-19.
- PubMed ID
- 18045214 [ View in PubMed]
- Abstract
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications. In the present work, we describe some examples and applications of the usefulness of the privileged structure concept for the structural design of new drug candidates, by discussing the eligibility of such motifs, including the identification of the N-acylhydrazone template as privileged structures.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Minaprine Acetylcholinesterase Protein Humans YesInhibitorDetails Minaprine Muscarinic acetylcholine receptor M1 Protein Humans UnknownAgonistDetails