Inhibition of ergosterol synthesis by sertaconazole in Candida albicans.

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Agut J, Palacin C, Sacristan A, Ortiz JA

Inhibition of ergosterol synthesis by sertaconazole in Candida albicans.

Arzneimittelforschung. 1992 May;42(5A):718-20.

PubMed ID

1627190 [ View in PubMed

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Abstract

7-Chloro-3-[1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl) ethoxy-methyl] benzo [b] thiophene (sertaconazole, FI-7045, CAS 99592-32-2), a new topical antifungal agent, has shown activity against a broad range of clinically relevant yeasts and fungi. In the present study, the molecular basis of the pharmacological action of sertaconazole was examined by investigating the inhibition of ergosterol synthesis in cultures of Candida albicans, ATCC E-10.231, at 6 x 10(5) cells/ml grown aerobically at 37 degrees C, using various concentrations of sertaconazole. Sertaconazole inhibited the ergosterol synthesis with IC50 = 115 nmol/l. The results show that one of the mechanisms of action of sertaconazole consists in the inhibition of ergosterol synthesis.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ketoconazole	Lanosterol 14-alpha demethylase	Protein		Yes	Inhibitor	Details
Sertaconazole	Cytochrome P450 51	Protein	Yeast	Yes	Inhibitor	Details