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Identification
NameKetoconazole
Accession NumberDB01026  (APRD00401)
TypeSmall Molecule
GroupsApproved, Investigational
Description

Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients. [PubChem]

Structure
Thumb
Synonyms
Extina
Ketoconazol
Ketoconazole
Ketoconazolum
Ketozole
Nizoral
Nizoral a-D
Xolegel
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Extinaaerosol, foam20 mg/gtopicalPrestium Pharma, Inc.2014-01-10Not applicableUs
Ketoconazoleshampoo20 mg/mLtopicalPatriot Pharmaceuticals, LLC2005-07-01Not applicableUs
Ketoderm Cream 2%cream2 %topicalTaropharma, A Division Of Taro Pharmaceuticals Inc.2002-05-23Not applicableCanada
Nizoralshampoo20 mg/mLtopicalA S Medication Solutions Llc1990-08-31Not applicableUs
Nizoralshampoo20 mg/mLtopicalJanssen Pharmaceuticals, Inc.1990-08-31Not applicableUs
Nizoraltablet200 mg/1oralJanssen Pharmaceuticals, Inc.1981-06-12Not applicableUs
Nizoral Cream 2%cream2 %topicalMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1988-12-312007-08-02Canada
Nizoral Oral Suspension 20mg/mlsuspension20 mgoralJanssen Pharmaceutica, Division Of Janssen Ortho Inc.1989-12-311998-02-06Canada
Nizoral Shp 2%shampoo2 %topicalJanssen Pharmaceutica, Division Of Janssen Ortho Inc.1990-12-311997-08-12Canada
Nizoral Tablets 200mgtablet200 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1984-12-312003-02-06Canada
Nu-ketocon Tablets - 200mgtablet200 mgoralNu Pharm Inc1998-09-012012-09-04Canada
Teva-ketoconazoletablet200 mgoralTeva Canada Limited1999-06-30Not applicableCanada
Xolegelgel2 %topicalBarrier Therapeutics Canada Inc.Not applicableNot applicableCanada
Xolegelgel20 mg/gtopicalAqua Pharmaceuticals2006-07-28Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-ketoconazoletablet200 mgoralApotex Inc1998-02-03Not applicableCanada
Ketoconazoletablet200 mg/1oralPd Rx Pharmaceuticals, Inc.2011-05-20Not applicableUs
Ketoconazolecream20 mg/gtopicalPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Ketoconazoletablet200 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Ketoconazolecream20 mg/gtopicalTeva Pharmaceuticals USA Inc2000-04-27Not applicableUs
Ketoconazoletablet200 mg/1oralPhysicians Total Care, Inc.2004-05-24Not applicableUs
Ketoconazoletablet200 mg/1oralAvera Mc Kennan Hospital2015-11-05Not applicableUs
Ketoconazoleshampoo, suspension20.5 mg/mLtopicalSandoz Inc.2005-11-04Not applicableUs
Ketoconazoletablet200 mg/1oralCarilion Materials Management1999-06-15Not applicableUs
Ketoconazoletablet200 mg/1oralTaro Pharmaceuticals U.S.A., Inc.1999-06-15Not applicableUs
Ketoconazoletablet200 mg/1oralAidarex Pharmaceuticals LLC1999-06-15Not applicableUs
Ketoconazoleshampoo, suspension20 mg/mLtopicalPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Ketoconazoleshampoo, suspension20 mg/mLtopicalAidarex Pharmaceuticals LLC2010-01-19Not applicableUs
Ketoconazolecream20 mg/gtopicalG&W Laboratories, Inc.2015-06-15Not applicableUs
Ketoconazoletablet200 mg/1oralAmerican Health Packaging2012-01-20Not applicableUs
Ketoconazolecream20 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.2002-12-18Not applicableUs
Ketoconazoletablet200 mg/1oralRebel Distributors Corp1999-06-15Not applicableUs
Ketoconazoletablet200 mg/1oralPreferred Pharmaceuticals, Inc.2013-02-05Not applicableUs
Ketoconazolecream20 mg/gtopicalREMEDYREPACK INC.2013-06-04Not applicableUs
Ketoconazoletablet200 mg/1oralMylan Pharmaceuticals Inc.2000-02-23Not applicableUs
Ketoconazoletablet200 mg/1oralbryant ranch prepack1999-06-15Not applicableUs
Ketoconazoletablet200 mg/1oralLake Erie Medical DBA Quality Care Products LLC1999-06-15Not applicableUs
Ketoconazolecream20 mg/gtopicalRebel Distributors Corp2002-12-18Not applicableUs
Ketoconazolecream20 mg/gtopicalPreferred Pharmaceuticals, Inc.2014-02-28Not applicableUs
Ketoconazolecream20 mg/gtopicalREMEDYREPACK INC.2013-05-06Not applicableUs
Ketoconazoletablet200 mg/1oralKAISER FOUNDATION HOSPITALS2010-03-02Not applicableUs
Ketoconazolecream20 mg/gtopicalDIRECT RX2014-01-01Not applicableUs
Ketoconazoletablet200 mg/1oralREMEDYREPACK INC.2011-07-14Not applicableUs
Ketoconazolecream20 mg/gtopicalRebel Distributors Corp2002-12-18Not applicableUs
Ketoconazoleshampoo, suspension20.5 mg/mLtopicalPreferred Pharmaceuticals, Inc.2014-06-16Not applicableUs
Ketoconazolecream20 mg/1topicalREMEDYREPACK INC.2013-04-15Not applicableUs
Ketoconazolecream20 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.2004-04-28Not applicableUs
Ketoconazoletablet200 mg/1oralGolden State Medical Supply, Inc.2009-05-20Not applicableUs
Ketoconazoleaerosol, foam2 g/100gtopicalPerrigo New York Inc2011-08-30Not applicableUs
Ketoconazolecream20 mg/gtopicalRebel Distributors Corp2002-12-18Not applicableUs
Ketoconazoletablet200 mg/1oralPreferred Pharmaceuticals, Inc.2011-05-31Not applicableUs
Ketoconazolecream20 mg/gtopicalREMEDYREPACK INC.2013-06-12Not applicableUs
Ketoconazolecream20 mg/gtopicalPhysicians Total Care, Inc.2001-08-01Not applicableUs
Ketoconazoletablet200 mg/1oralTeva Pharmaceuticals USA Inc1999-06-15Not applicableUs
Ketoconazoleshampoo, suspension20 mg/mLtopicalPhysicians Total Care, Inc.2006-07-24Not applicableUs
Ketoconazolecream20 mg/gtopicalUnit Dose Services2004-04-28Not applicableUs
Ketoconazoleshampoo, suspension20 mg/mLtopicalPerrigo New York Inc2010-01-19Not applicableUs
Ketoconazoletablet200 mg/1oralREMEDYREPACK INC.2013-03-15Not applicableUs
Ketoconazoletablet200 mg/1oralSTAT Rx USA LLC2011-05-31Not applicableUs
Ketoconazolecream20 mg/gtopicalDispensing Solutions, Inc.2002-12-18Not applicableUs
KetodankitMedimetriks Pharmaceuticals, Inc.2012-06-15Not applicableUs
Ketodanaerosol, foam20 mg/gtopicalMedimetriks Pharmaceuticals, Inc.2012-06-15Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nizoral - 2%shampoo2 %topicalJohnson & Johnson Inc1990-12-30Not applicableCanada
Nizoral A-Dshampoo10 mg/mLtopicalJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division1999-04-01Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
FungarestJanssen-Cilag
FungoralJohnson & Johnson
KetodermHessel
KetoisdinIsdin
KetozoleRanbaxy
Nizoral CreamOrtho-McNeil
Nizoral ShampooOrtho-McNeil
OrifungalJanssen
Orifungal MJanssen
PanfungolEsteve
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIR9400W927I
CAS number65277-42-1
WeightAverage: 531.431
Monoisotopic: 530.148760818
Chemical FormulaC26H28Cl2N4O4
InChI KeyInChIKey=XMAYWYJOQHXEEK-UHFFFAOYSA-N
InChI
InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3
IUPAC Name
1-[4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one
SMILES
CC(=O)N1CCN(CC1)C1=CC=C(OCC2COC(CN3C=CN=C3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassDiazinanes
Sub ClassPiperazines
Direct ParentPhenylpiperazines
Alternative Parents
Substituents
  • N-arylpiperazine
  • Phenylpiperazine
  • Substituted aniline
  • Dialkylarylamine
  • Phenol ether
  • 1,3-dichlorobenzene
  • Glycerol ether
  • Halobenzene
  • Chlorobenzene
  • Aniline
  • Alkyl aryl ether
  • Benzenoid
  • N-substituted imidazole
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Acetamide
  • Tertiary carboxylic acid amide
  • Imidazole
  • Azole
  • Meta-dioxolane
  • Tertiary amine
  • Carboxamide group
  • Oxacycle
  • Azacycle
  • Ether
  • Carboxylic acid derivative
  • Acetal
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
PharmacodynamicsKetoconazole, like clotrimazole, fluconazole, itraconazole, and miconazole, is an imidazole antifungal agent.
Mechanism of actionKetoconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and increased fungal cellular permeability. Other mechanisms may involve the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone.
Related Articles
AbsorptionModerate
Volume of distributionNot Available
Protein binding99% (in vitro, plasma protein binding)
Metabolism

Hepatic

Route of eliminationNot Available
Half life2 hours
ClearanceNot Available
ToxicityHepatotoxicity, LD50=86 mg/kg (orally in rat)
Affected organisms
  • Fungi
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9156
Blood Brain Barrier+0.6704
Caco-2 permeable+0.8866
P-glycoprotein substrateSubstrate0.7293
P-glycoprotein inhibitor IInhibitor0.8389
P-glycoprotein inhibitor IIInhibitor0.8388
Renal organic cation transporterNon-inhibitor0.5644
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateSubstrate0.7409
CYP450 1A2 substrateInhibitor0.9106
CYP450 2C9 inhibitorInhibitor0.8949
CYP450 2D6 inhibitorInhibitor0.8931
CYP450 2C19 inhibitorInhibitor0.8994
CYP450 3A4 inhibitorInhibitor0.796
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9386
Ames testNon AMES toxic0.7003
CarcinogenicityNon-carcinogens0.8836
BiodegradationNot ready biodegradable1.0
Rat acute toxicity3.4739 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9258
hERG inhibition (predictor II)Inhibitor0.8403
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Aerosol, foamtopical20 mg/g
Aerosol, foamtopical2 g/100g
Creamtopical20 mg/g
Creamtopical20 mg/1
Shampootopical20 mg/mL
Shampoo, suspensiontopical20 mg/mL
Shampoo, suspensiontopical20.5 mg/mL
Tabletoral200 mg/1
Kit
Creamtopical2 %
Shampootopical2 %
Shampootopical10 mg/mL
Suspensionoral20 mg
Tabletoral200 mg
Geltopical2 %
Geltopical20 mg/g
Prices
Unit descriptionCostUnit
Extina 2% Foam 100 gm Can375.44USD can
Extina 2% Foam 50 gm Can201.53USD can
Nizoral 2% Shampoo 120ml Bottle49.43USD bottle
Ketoconazole 2% Cream 60 gm Tube44.72USD tube
Ketoconazole 2% Cream 30 gm Tube29.43USD tube
Ketoconazole 2% Shampoo 120ml Bottle27.98USD bottle
Ketoconazole 2% Cream 15 gm Tube19.99USD tube
Ketoconazole powder15.0USD g
Nizoral 200 mg tablet4.75USD tablet
Extina 2% foam3.61USD g
Ketoconazole 200 mg tablet3.21USD tablet
Kuric 2% cream1.54USD g
Apo-Ketoconazole 200 mg Tablet1.24USD tablet
Novo-Ketoconazole 200 mg Tablet1.24USD tablet
Nu-Ketocon 200 mg Tablet1.24USD tablet
Nizoral 2% cream1.22USD g
Ketoconazole 2% cream1.1USD g
Ketoderm 2 % Cream0.35USD g
Ketoconazole 2% shampoo0.23USD ml
Nizoral a-d 1% shampoo0.07USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5456851 No1994-04-072014-04-07Us
US7179475 No1998-12-042018-12-04Us
US7553835 No1998-10-192018-10-19Us
US8026238 No1998-10-192018-10-19Us
US8232276 No2000-11-242020-11-24Us
US8735393 No1998-12-042018-12-04Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point146U.S. Patent 4,144,346.
water solubility0.0866 mg/LNot Available
logP4.35SANGSTER (1993)
Predicted Properties
PropertyValueSource
Water Solubility0.00931 mg/mLALOGPS
logP4.3ALOGPS
logP4.19ChemAxon
logS-4.8ALOGPS
pKa (Strongest Basic)6.75ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area69.06 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity138.07 m3·mol-1ChemAxon
Polarizability54.83 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

U.S. Patent 4,144,346.

General References
  1. Goeders NE, Peltier RL, Guerin GF: Ketoconazole reduces low dose cocaine self-administration in rats. Drug Alcohol Depend. 1998 Dec 1;53(1):67-77. [PubMed:10933341 ]
  2. Berwaerts J, Verhelst J, Mahler C, Abs R: Cushing's syndrome in pregnancy treated by ketoconazole: case report and review of the literature. Gynecol Endocrinol. 1999 Jun;13(3):175-82. [PubMed:10451809 ]
  3. Kazy Z, Puho E, Czeizel AE: Population-based case-control study of oral ketoconazole treatment for birth outcomes. Congenit Anom (Kyoto). 2005 Mar;45(1):5-8. [PubMed:15737124 ]
  4. Pierard-Franchimont C, Goffin V, Decroix J, Pierard GE: A multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitis. Skin Pharmacol Appl Skin Physiol. 2002 Nov-Dec;15(6):434-41. [PubMed:12476017 ]
External Links
ATC CodesG01AF11D01AC08J02AB02
AHFS Codes
  • 08:14.08
  • 84:04.08.08
PDB EntriesNot Available
FDA labelDownload (222 KB)
MSDSDownload (73.3 KB)
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Ketoconazole.
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Ketoconazole.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Ketoconazole.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Ketoconazole.
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Ketoconazole.
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Ketoconazole.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Ketoconazole.
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Ketoconazole.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Ketoconazole.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Ketoconazole.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Ketoconazole.
AjmalineThe metabolism of Ajmaline can be decreased when combined with Ketoconazole.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Ketoconazole.
AlbendazoleThe serum concentration of Ketoconazole can be increased when it is combined with Albendazole.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Ketoconazole.
AldosteroneThe serum concentration of Ketoconazole can be decreased when it is combined with Aldosterone.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Ketoconazole.
AlectinibThe serum concentration of Ketoconazole can be increased when it is combined with Alectinib.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Ketoconazole.
AlfentanilThe serum concentration of Ketoconazole can be increased when it is combined with Alfentanil.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Ketoconazole.
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Ketoconazole.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Ketoconazole.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Ketoconazole.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Ketoconazole.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Ketoconazole.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Ketoconazole.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Ketoconazole.
AlprenololThe metabolism of Alprenolol can be decreased when combined with Ketoconazole.
Aluminum hydroxideThe serum concentration of Ketoconazole can be decreased when it is combined with Aluminum hydroxide.
Aluminum phosphateThe serum concentration of Ketoconazole can be decreased when it is combined with Aluminum phosphate.
AmantadineThe serum concentration of Ketoconazole can be increased when it is combined with Amantadine.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Ketoconazole.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Ketoconazole.
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Ketoconazole.
Aminohippuric acidThe serum concentration of Ketoconazole can be increased when it is combined with Aminohippuric acid.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Ketoconazole.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Ketoconazole.
AmiodaroneThe serum concentration of Ketoconazole can be decreased when it is combined with Amiodarone.
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Ketoconazole.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Ketoconazole.
AmlodipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Amlodipine.
AmlodipineThe serum concentration of Ketoconazole can be increased when it is combined with Amlodipine.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Ketoconazole.
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Ketoconazole.
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Ketoconazole.
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Ketoconazole.
Amphotericin BThe therapeutic efficacy of Amphotericin B can be decreased when used in combination with Ketoconazole.
AmprenavirThe serum concentration of Ketoconazole can be decreased when it is combined with Amprenavir.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Ketoconazole.
AmrinoneThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Amrinone.
AmsacrineThe serum concentration of Ketoconazole can be increased when it is combined with Amsacrine.
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Ketoconazole.
AnagrelideKetoconazole may increase the QTc-prolonging activities of Anagrelide.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Ketoconazole.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Ketoconazole.
ApremilastThe metabolism of Apremilast can be decreased when combined with Ketoconazole.
AprepitantThe serum concentration of Ketoconazole can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Ketoconazole.
AprindineThe metabolism of Aprindine can be decreased when combined with Ketoconazole.
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Ketoconazole.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Ketoconazole.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Ketoconazole.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Ketoconazole.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Ketoconazole.
ArtemetherThe metabolism of Artemether can be decreased when combined with Ketoconazole.
ArtesunateThe serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Ketoconazole resulting in a loss in efficacy.
AsenapineThe serum concentration of Ketoconazole can be decreased when it is combined with Asenapine.
AsenapineThe metabolism of Asenapine can be decreased when combined with Ketoconazole.
AstemizoleKetoconazole may increase the QTc-prolonging activities of Astemizole.
AstemizoleThe serum concentration of Ketoconazole can be increased when it is combined with Astemizole.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Ketoconazole.
AtenololThe serum concentration of Atenolol can be increased when it is combined with Ketoconazole.
AtomoxetineThe metabolism of Ketoconazole can be decreased when combined with Atomoxetine.
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Ketoconazole.
AtorvastatinThe serum concentration of Ketoconazole can be increased when it is combined with Atorvastatin.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Ketoconazole.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Ketoconazole.
AzelastineThe serum concentration of Ketoconazole can be increased when it is combined with Azelastine.
AzelastineThe metabolism of Azelastine can be decreased when combined with Ketoconazole.
AzelnidipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Azelnidipine.
AzimilideThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Azimilide.
AzithromycinKetoconazole may increase the QTc-prolonging activities of Azithromycin.
AzithromycinThe serum concentration of Ketoconazole can be increased when it is combined with Azithromycin.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Ketoconazole.
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Ketoconazole.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Ketoconazole.
BedaquilineKetoconazole may increase the QTc-prolonging activities of Bedaquiline.
BenidipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Benidipine.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Ketoconazole.
BenzocaineThe serum concentration of Ketoconazole can be increased when it is combined with Benzocaine.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Ketoconazole.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Ketoconazole.
BepridilThe serum concentration of Ketoconazole can be increased when it is combined with Bepridil.
BepridilThe metabolism of Bepridil can be decreased when combined with Ketoconazole.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Ketoconazole.
BetaxololThe metabolism of Betaxolol can be decreased when combined with Ketoconazole.
BexaroteneThe serum concentration of Ketoconazole can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Ketoconazole.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Ketoconazole.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Ketoconazole.
BiperidenThe serum concentration of Ketoconazole can be increased when it is combined with Biperiden.
Bismuth SubcitrateThe serum concentration of Ketoconazole can be decreased when it is combined with Bismuth Subcitrate.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Ketoconazole.
BoceprevirThe metabolism of Ketoconazole can be decreased when combined with Boceprevir.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Ketoconazole.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Ketoconazole.
BortezomibThe metabolism of Ketoconazole can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Ketoconazole can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Ketoconazole.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Ketoconazole.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Ketoconazole.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Ketoconazole.
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Ketoconazole.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Ketoconazole.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Ketoconazole.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Ketoconazole.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Ketoconazole.
BufuralolThe metabolism of Bufuralol can be decreased when combined with Ketoconazole.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Ketoconazole.
BuprenorphineThe serum concentration of Ketoconazole can be increased when it is combined with Buprenorphine.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Ketoconazole.
BupropionThe metabolism of Bupropion can be decreased when combined with Ketoconazole.
BuspironeThe serum concentration of Ketoconazole can be increased when it is combined with Buspirone.
BuspironeThe metabolism of Buspirone can be decreased when combined with Ketoconazole.
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Ketoconazole.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Ketoconazole.
CabergolineThe metabolism of Cabergoline can be decreased when combined with Ketoconazole.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Ketoconazole.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Ketoconazole.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Ketoconazole.
Calcium carbonateThe serum concentration of Ketoconazole can be decreased when it is combined with Calcium carbonate.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Ketoconazole.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Ketoconazole.
CandesartanThe serum concentration of Ketoconazole can be increased when it is combined with Candesartan.
CandesartanThe metabolism of Candesartan can be decreased when combined with Ketoconazole.
CaptoprilThe serum concentration of Ketoconazole can be increased when it is combined with Captopril.
CaptoprilThe metabolism of Captopril can be decreased when combined with Ketoconazole.
CarbamazepineThe serum concentration of Ketoconazole can be decreased when it is combined with Carbamazepine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Ketoconazole.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Ketoconazole.
CarbocisteineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Carbocisteine.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Ketoconazole.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Ketoconazole.
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Ketoconazole.
CarteololThe metabolism of Carteolol can be decreased when combined with Ketoconazole.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Ketoconazole.
CaspofunginThe serum concentration of Ketoconazole can be increased when it is combined with Caspofungin.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Ketoconazole.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Ketoconazole.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Ketoconazole.
CeritinibThe serum concentration of Ketoconazole can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Ketoconazole.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Ketoconazole.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Ketoconazole.
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Ketoconazole.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Ketoconazole.
ChloroquineKetoconazole may increase the QTc-prolonging activities of Chloroquine.
ChloroquineThe serum concentration of Ketoconazole can be increased when it is combined with Chloroquine.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Ketoconazole.
ChlorpromazineKetoconazole may increase the QTc-prolonging activities of Chlorpromazine.
ChlorpromazineThe serum concentration of Ketoconazole can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Ketoconazole can be increased when it is combined with Chlorpropamide.
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Ketoconazole.
ChlorprothixeneThe serum concentration of Ketoconazole can be increased when it is combined with Chlorprothixene.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Ketoconazole.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Ketoconazole.
CholesterolThe serum concentration of Ketoconazole can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Ketoconazole can be decreased when it is combined with Cholic Acid.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Ketoconazole.
CilazaprilThe serum concentration of Ketoconazole can be increased when it is combined with Cilazapril.
CilnidipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Cilnidipine.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Ketoconazole.
CimetidineThe serum concentration of Ketoconazole can be decreased when it is combined with Cimetidine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Ketoconazole.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Ketoconazole.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Ketoconazole.
CiprofloxacinKetoconazole may increase the QTc-prolonging activities of Ciprofloxacin.
CiprofloxacinThe serum concentration of Ketoconazole can be increased when it is combined with Ciprofloxacin.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Ketoconazole.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Ketoconazole.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Ketoconazole.
ClarithromycinKetoconazole may increase the QTc-prolonging activities of Clarithromycin.
ClarithromycinThe serum concentration of Ketoconazole can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Ketoconazole can be decreased when combined with Clemastine.
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Ketoconazole.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Ketoconazole.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Ketoconazole.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Ketoconazole.
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Ketoconazole.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Ketoconazole.
ClofazimineThe serum concentration of Ketoconazole can be increased when it is combined with Clofazimine.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Ketoconazole.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Ketoconazole.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Ketoconazole.
ClomipramineThe serum concentration of Ketoconazole can be increased when it is combined with Clomipramine.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Ketoconazole.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Ketoconazole.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Ketoconazole.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Ketoconazole.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Ketoconazole.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Ketoconazole.
ClotrimazoleThe metabolism of Ketoconazole can be decreased when combined with Clotrimazole.
ClozapineKetoconazole may increase the QTc-prolonging activities of Clozapine.
CobicistatThe serum concentration of Cobicistat can be increased when it is combined with Ketoconazole.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Ketoconazole.
CocaineThe metabolism of Cocaine can be decreased when combined with Ketoconazole.
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Ketoconazole.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Ketoconazole.
ColforsinThe serum concentration of Ketoconazole can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Ketoconazole can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Ketoconazole.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Ketoconazole.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Ketoconazole.
CrizotinibThe metabolism of Ketoconazole can be decreased when combined with Crizotinib.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Ketoconazole.
CyclophosphamideThe serum concentration of Ketoconazole can be increased when it is combined with Cyclophosphamide.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Ketoconazole.
CyclosporineThe metabolism of Ketoconazole can be decreased when combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Ketoconazole.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Ketoconazole.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Ketoconazole.
DabrafenibThe serum concentration of Ketoconazole can be decreased when it is combined with Dabrafenib.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Ketoconazole.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Ketoconazole.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Ketoconazole.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Ketoconazole.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Ketoconazole.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Ketoconazole.
DapsoneThe metabolism of Dapsone can be decreased when combined with Ketoconazole.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Ketoconazole.
DarodipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Darodipine.
DarunavirThe serum concentration of Ketoconazole can be increased when it is combined with Darunavir.
DarunavirThe metabolism of Darunavir can be decreased when combined with Ketoconazole.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Ketoconazole.
DasatinibThe serum concentration of Ketoconazole can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Ketoconazole can be decreased when it is combined with Daunorubicin.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Ketoconazole.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Ketoconazole.
DeferasiroxThe serum concentration of Ketoconazole can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Ketoconazole.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Ketoconazole.
DelavirdineThe metabolism of Ketoconazole can be decreased when combined with Delavirdine.
DesipramineThe serum concentration of Ketoconazole can be increased when it is combined with Desipramine.
DesipramineThe metabolism of Desipramine can be decreased when combined with Ketoconazole.
DesloratadineThe serum concentration of Ketoconazole can be increased when it is combined with Desloratadine.
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Ketoconazole.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Ketoconazole.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Ketoconazole.
DexamethasoneThe serum concentration of Ketoconazole can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Ketoconazole.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Ketoconazole.
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Ketoconazole.
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Ketoconazole.
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Ketoconazole.
DextromethorphanThe serum concentration of Ketoconazole can be increased when it is combined with Dextromethorphan.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Ketoconazole.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Ketoconazole.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Ketoconazole.
DiclofenacThe serum concentration of Ketoconazole can be increased when it is combined with Diclofenac.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Ketoconazole.
DicoumarolThe serum concentration of Dicoumarol can be increased when it is combined with Ketoconazole.
DidanosineDidanosine can cause a decrease in the absorption of Ketoconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
DienogestThe serum concentration of Dienogest can be increased when it is combined with Ketoconazole.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Ketoconazole.
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Ketoconazole.
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Ketoconazole.
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Ketoconazole.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Ketoconazole.
DigoxinThe serum concentration of Ketoconazole can be decreased when it is combined with Digoxin.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Ketoconazole.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Ketoconazole.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Ketoconazole.
DihydroergotamineThe metabolism of Ketoconazole can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ketoconazole.
DiltiazemThe metabolism of Ketoconazole can be decreased when combined with Diltiazem.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Ketoconazole.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Ketoconazole.
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Ketoconazole.
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Ketoconazole.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Ketoconazole.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Ketoconazole.
DofetilideThe metabolism of Dofetilide can be decreased when combined with Ketoconazole.
DolasetronKetoconazole may increase the QTc-prolonging activities of Dolasetron.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Ketoconazole.
DonepezilThe metabolism of Donepezil can be decreased when combined with Ketoconazole.
DopamineThe metabolism of Dopamine can be decreased when combined with Ketoconazole.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Ketoconazole.
DotarizineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Dotarizine.
DoxazosinThe serum concentration of Ketoconazole can be increased when it is combined with Doxazosin.
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Ketoconazole.
DoxepinThe serum concentration of Ketoconazole can be increased when it is combined with Doxepin.
DoxepinThe metabolism of Doxepin can be decreased when combined with Ketoconazole.
DoxorubicinThe serum concentration of Ketoconazole can be decreased when it is combined with Doxorubicin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Ketoconazole.
DoxycyclineThe metabolism of Ketoconazole can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Ketoconazole.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Ketoconazole.
DronedaroneThe metabolism of Ketoconazole can be decreased when combined with Dronedarone.
DroperidolKetoconazole may increase the QTc-prolonging activities of Droperidol.
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Ketoconazole.
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Ketoconazole.
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Ketoconazole.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Ketoconazole.
EfavirenzThe serum concentration of Ketoconazole can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Ketoconazole.
EfonidipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Efonidipine.
ElbasvirThe serum concentration of Ketoconazole can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Ketoconazole.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Ketoconazole.
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Ketoconazole.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Ketoconazole.
EnalaprilThe serum concentration of Ketoconazole can be increased when it is combined with Enalapril.
EncainideThe metabolism of Encainide can be decreased when combined with Ketoconazole.
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Ketoconazole.
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Ketoconazole.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Ketoconazole.
EperisoneThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Eperisone.
EpinastineThe serum concentration of Ketoconazole can be decreased when it is combined with Epinastine.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Ketoconazole.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Ketoconazole.
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Ketoconazole.
EquileninThe serum concentration of Equilenin can be increased when it is combined with Ketoconazole.
EquilinThe serum concentration of Equilin can be increased when it is combined with Ketoconazole.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Ketoconazole.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Ketoconazole.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Ketoconazole.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Ketoconazole.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Ketoconazole.
ErythromycinKetoconazole may increase the QTc-prolonging activities of Erythromycin.
ErythromycinThe metabolism of Ketoconazole can be decreased when combined with Erythromycin.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Ketoconazole.
Eslicarbazepine acetateThe serum concentration of Ketoconazole can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Ketoconazole.
EsomeprazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Esomeprazole.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Ketoconazole.
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Ketoconazole.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Ketoconazole.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Ketoconazole.
EstramustineThe metabolism of Estramustine can be decreased when combined with Ketoconazole.
EstramustineThe serum concentration of Ketoconazole can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Ketoconazole can be decreased when it is combined with Estriol.
EstriolThe serum concentration of Estriol can be increased when it is combined with Ketoconazole.
EstroneThe serum concentration of Ketoconazole can be decreased when it is combined with Estrone.
EstroneThe serum concentration of Estrone can be increased when it is combined with Ketoconazole.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Ketoconazole.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Ketoconazole.
EthanolThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Ethanol.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ketoconazole.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Ketoconazole.
Ethyl biscoumacetateThe serum concentration of Ethyl biscoumacetate can be increased when it is combined with Ketoconazole.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Ketoconazole.
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Ketoconazole.
EtodolacThe metabolism of Etodolac can be decreased when combined with Ketoconazole.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Ketoconazole.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Ketoconazole.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Ketoconazole.
EtravirineThe serum concentration of Ketoconazole can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Ketoconazole.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Ketoconazole.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Ketoconazole.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Ketoconazole.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Ketoconazole.
FamotidineThe serum concentration of Ketoconazole can be decreased when it is combined with Famotidine.
FamotidineThe metabolism of Famotidine can be decreased when combined with Ketoconazole.
FelbamateThe metabolism of Felbamate can be decreased when combined with Ketoconazole.
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Ketoconazole.
FendilineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Fendiline.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Ketoconazole.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Ketoconazole.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Ketoconazole.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Ketoconazole.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Ketoconazole.
FimasartanThe serum concentration of Fimasartan can be increased when it is combined with Ketoconazole.
FinasterideThe metabolism of Finasteride can be decreased when combined with Ketoconazole.
FingolimodThe serum concentration of the active metabolites of Fingolimod can be increased when Fingolimod is used in combination with Ketoconazole.
FlecainideKetoconazole may increase the QTc-prolonging activities of Flecainide.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Ketoconazole.
FluconazoleThe metabolism of Ketoconazole can be decreased when combined with Fluconazole.
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Ketoconazole.
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Ketoconazole.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Ketoconazole.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Ketoconazole.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Ketoconazole.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Ketoconazole.
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Ketoconazole.
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Ketoconazole.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Ketoconazole.
FluoxetineThe serum concentration of Ketoconazole can be increased when it is combined with Fluoxetine.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Ketoconazole.
FlupentixolThe serum concentration of Ketoconazole can be increased when it is combined with Flupentixol.
FlupentixolKetoconazole may increase the QTc-prolonging activities of Flupentixol.
FluphenazineThe serum concentration of Ketoconazole can be increased when it is combined with Fluphenazine.
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Ketoconazole.
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Ketoconazole.
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Ketoconazole.
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Ketoconazole.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Ketoconazole.
FlurazepamThe serum concentration of Ketoconazole can be increased when it is combined with Flurazepam.
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Ketoconazole.
FlutamideThe metabolism of Flutamide can be decreased when combined with Ketoconazole.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Ketoconazole.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Ketoconazole.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Ketoconazole.
FluvoxamineThe metabolism of Ketoconazole can be decreased when combined with Fluvoxamine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Ketoconazole.
FosamprenavirThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Ketoconazole.
FosamprenavirThe metabolism of Ketoconazole can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Ketoconazole can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Ketoconazole can be decreased when it is combined with Fosphenytoin.
FosphenytoinThe metabolism of Fosphenytoin can be decreased when combined with Ketoconazole.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Ketoconazole.
Fusidic AcidThe serum concentration of Ketoconazole can be increased when it is combined with Fusidic Acid.
GabapentinThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Gabapentin.
Gadobenic acidKetoconazole may increase the QTc-prolonging activities of Gadobenic acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Ketoconazole.
GavestinelThe metabolism of Gavestinel can be decreased when combined with Ketoconazole.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Ketoconazole.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Ketoconazole.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Ketoconazole.
GemifloxacinKetoconazole may increase the QTc-prolonging activities of Gemifloxacin.
GenisteinThe serum concentration of Ketoconazole can be increased when it is combined with Genistein.
GliclazideThe metabolism of Gliclazide can be decreased when combined with Ketoconazole.
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Ketoconazole.
GlipizideThe metabolism of Glipizide can be decreased when combined with Ketoconazole.
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Ketoconazole.
GlyburideThe serum concentration of Ketoconazole can be increased when it is combined with Glyburide.
GlyburideThe metabolism of Glyburide can be decreased when combined with Ketoconazole.
GlycerolThe serum concentration of Ketoconazole can be increased when it is combined with Glycerol.
GoserelinKetoconazole may increase the QTc-prolonging activities of Goserelin.
Gramicidin DThe serum concentration of Ketoconazole can be increased when it is combined with Gramicidin D.
GranisetronKetoconazole may increase the QTc-prolonging activities of Granisetron.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Ketoconazole.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Ketoconazole.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Ketoconazole.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Ketoconazole.
HaloperidolKetoconazole may increase the QTc-prolonging activities of Haloperidol.
HaloperidolThe serum concentration of Ketoconazole can be increased when it is combined with Haloperidol.
HalothaneThe metabolism of Halothane can be decreased when combined with Ketoconazole.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Ketoconazole.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Ketoconazole.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Ketoconazole.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Ketoconazole.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Ketoconazole.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Ketoconazole.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Ketoconazole.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Ketoconazole.
IbutilideKetoconazole may increase the QTc-prolonging activities of Ibutilide.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Ketoconazole.
IdelalisibThe serum concentration of Ketoconazole can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Ketoconazole resulting in a loss in efficacy.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Ketoconazole.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Ketoconazole.
ImatinibThe metabolism of Ketoconazole can be decreased when combined with Imatinib.
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Ketoconazole.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Ketoconazole.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Ketoconazole.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Ketoconazole.
IndapamideThe metabolism of Indapamide can be decreased when combined with Ketoconazole.
IndinavirThe serum concentration of Ketoconazole can be decreased when it is combined with Indinavir.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Ketoconazole.
indisulamThe metabolism of indisulam can be decreased when combined with Ketoconazole.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Ketoconazole.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Ketoconazole.
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Ketoconazole.
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Ketoconazole.
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Ketoconazole.
IsavuconazoniumThe metabolism of Ketoconazole can be decreased when combined with Isavuconazonium.
IsoniazidThe serum concentration of Ketoconazole can be decreased when it is combined with Isoniazid.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Ketoconazole.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Ketoconazole.
IsradipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Isradipine.
IsradipineThe metabolism of Ketoconazole can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Ketoconazole.
ItraconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Itraconazole.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Ketoconazole.
IvacaftorThe serum concentration of Ketoconazole can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Ketoconazole.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Ketoconazole.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Ketoconazole.
KetamineThe serum concentration of Ketoconazole can be increased when it is combined with Ketamine.
KetamineThe metabolism of Ketamine can be decreased when combined with Ketoconazole.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Ketoconazole.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Ketoconazole.
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Ketoconazole.
LabetalolThe metabolism of Labetalol can be decreased when combined with Ketoconazole.
LacidipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Lacidipine.
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Ketoconazole.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Ketoconazole.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Ketoconazole.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Ketoconazole.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Ketoconazole.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Ketoconazole.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Ketoconazole.
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Ketoconazole.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Ketoconazole.
LenvatinibKetoconazole may increase the QTc-prolonging activities of Lenvatinib.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Ketoconazole.
LesinuradThe metabolism of Lesinurad can be decreased when combined with Ketoconazole.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Ketoconazole.
LeuprolideKetoconazole may increase the QTc-prolonging activities of Leuprolide.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Ketoconazole.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Ketoconazole.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Ketoconazole.
LevodopaThe metabolism of Levodopa can be decreased when combined with Ketoconazole.
LevofloxacinKetoconazole may increase the QTc-prolonging activities of Levofloxacin.
LevofloxacinThe serum concentration of Ketoconazole can be increased when it is combined with Levofloxacin.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Ketoconazole.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Ketoconazole.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Ketoconazole.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Ketoconazole.
LevothyroxineThe serum concentration of Ketoconazole can be decreased when it is combined with Levothyroxine.
LicofeloneThe metabolism of Licofelone can be decreased when combined with Ketoconazole.
LidocaineThe serum concentration of Ketoconazole can be increased when it is combined with Lidocaine.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Ketoconazole.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Ketoconazole.
LiothyronineThe serum concentration of Ketoconazole can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Ketoconazole can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Ketoconazole can be increased when it is combined with Lisinopril.
LisurideThe metabolism of Lisuride can be decreased when combined with Ketoconazole.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Ketoconazole.
LomustineThe metabolism of Lomustine can be decreased when combined with Ketoconazole.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Ketoconazole.
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Ketoconazole.
LoratadineThe serum concentration of Ketoconazole can be increased when it is combined with Loratadine.
LoratadineThe metabolism of Loratadine can be decreased when combined with Ketoconazole.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Ketoconazole.
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Ketoconazole.
LosartanThe metabolism of Losartan can be decreased when combined with Ketoconazole.
LosartanThe serum concentration of Ketoconazole can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Ketoconazole.
LovastatinThe metabolism of Ketoconazole can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Ketoconazole can be decreased when it is combined with Lumacaftor.
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Ketoconazole.
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Ketoconazole.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Ketoconazole.
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Ketoconazole.
MagaldrateThe serum concentration of Ketoconazole can be decreased when it is combined with Magaldrate.
Magnesium carbonateThe serum concentration of Ketoconazole can be decreased when it is combined with Magnesium carbonate.
Magnesium hydroxideThe serum concentration of Ketoconazole can be decreased when it is combined with Magnesium hydroxide.
Magnesium oxideThe serum concentration of Ketoconazole can be decreased when it is combined with Magnesium oxide.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Magnesium Sulfate.
Magnesium TrisilicateThe serum concentration of Ketoconazole can be decreased when it is combined with Magnesium Trisilicate.
ManidipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Manidipine.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Ketoconazole.
MaprotilineThe serum concentration of Ketoconazole can be increased when it is combined with Maprotiline.
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Ketoconazole.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Ketoconazole.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Ketoconazole.
MebendazoleThe serum concentration of Ketoconazole can be increased when it is combined with Mebendazole.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Ketoconazole.
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Ketoconazole.
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Ketoconazole.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Ketoconazole.
MefloquineThe serum concentration of Ketoconazole can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Ketoconazole can be increased when it is combined with Megestrol acetate.
MelatoninThe metabolism of Melatonin can be decreased when combined with Ketoconazole.
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Ketoconazole.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Ketoconazole.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Ketoconazole.
MeprobamateThe serum concentration of Ketoconazole can be increased when it is combined with Meprobamate.
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Ketoconazole.
MequitazineThe metabolism of Mequitazine can be decreased when combined with Ketoconazole.
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Ketoconazole.
MestranolThe metabolism of Mestranol can be decreased when combined with Ketoconazole.
MethadoneThe serum concentration of Methadone can be increased when it is combined with Ketoconazole.
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Ketoconazole.
MethanthelineThe serum concentration of Ketoconazole can be decreased when it is combined with Methantheline.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Ketoconazole.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Ketoconazole.
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Ketoconazole.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Ketoconazole.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Ketoconazole.
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Ketoconazole.
MethylergometrineThe serum concentration of Methylergometrine can be increased when it is combined with Ketoconazole.
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Ketoconazole.
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Ketoconazole.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Ketoconazole.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Ketoconazole.
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Ketoconazole.
MetiamideThe serum concentration of Ketoconazole can be decreased when it is combined with Metiamide.
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Ketoconazole.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Ketoconazole.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Ketoconazole.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Ketoconazole.
MianserinThe metabolism of Mianserin can be decreased when combined with Ketoconazole.
MibefradilThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Mibefradil.
MibefradilThe serum concentration of Ketoconazole can be increased when it is combined with Mibefradil.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Ketoconazole.
MiconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Ketoconazole.
MidazolamThe serum concentration of Ketoconazole can be decreased when it is combined with Midazolam.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Ketoconazole.
MifepristoneThe metabolism of Ketoconazole can be decreased when combined with Mifepristone.
MinaprineThe metabolism of Minaprine can be decreased when combined with Ketoconazole.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Ketoconazole.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Ketoconazole.
MitomycinThe serum concentration of Ketoconazole can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Ketoconazole can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Ketoconazole can be decreased when it is combined with Mitoxantrone.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Ketoconazole.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Ketoconazole.
ModafinilThe serum concentration of Ketoconazole can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Ketoconazole.
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Ketoconazole.
MontelukastThe metabolism of Montelukast can be decreased when combined with Ketoconazole.
MorphineThe serum concentration of Morphine can be increased when it is combined with Ketoconazole.
MoxifloxacinKetoconazole may increase the QTc-prolonging activities of Moxifloxacin.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Ketoconazole.
NadololThe serum concentration of Nadolol can be increased when it is combined with Ketoconazole.
NafcillinThe serum concentration of Ketoconazole can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Ketoconazole.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Ketoconazole.
NaltrexoneThe serum concentration of Ketoconazole can be increased when it is combined with Naltrexone.
NaproxenThe metabolism of Naproxen can be decreased when combined with Ketoconazole.
NaringeninThe serum concentration of Ketoconazole can be increased when it is combined with Naringenin.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Ketoconazole.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Ketoconazole.
NefazodoneThe serum concentration of Ketoconazole can be decreased when it is combined with Nefazodone.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Ketoconazole.
NelfinavirThe serum concentration of Ketoconazole can be decreased when it is combined with Nelfinavir.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Ketoconazole.
NeostigmineThe serum concentration of Ketoconazole can be increased when it is combined with Neostigmine.
NetupitantThe serum concentration of Ketoconazole can be increased when it is combined with Netupitant.
NetupitantThe metabolism of Netupitant can be decreased when combined with Ketoconazole.
NevirapineThe serum concentration of Ketoconazole can be decreased when it is combined with Nevirapine.
NevirapineThe metabolism of Nevirapine can be decreased when combined with Ketoconazole.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Ketoconazole.
NicergolineThe metabolism of Nicergoline can be decreased when combined with Ketoconazole.
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Ketoconazole.
NicotineThe metabolism of Nicotine can be decreased when combined with Ketoconazole.
NifedipineThe serum concentration of Ketoconazole can be decreased when it is combined with Nifedipine.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Ketoconazole.
NiguldipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Niguldipine.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Ketoconazole.
NilotinibThe metabolism of Ketoconazole can be decreased when combined with Nilotinib.
NiludipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Niludipine.
NilutamideThe metabolism of Nilutamide can be decreased when combined with Ketoconazole.
NilvadipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Nilvadipine.
NimesulideThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Nimesulide.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Ketoconazole.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Ketoconazole.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Ketoconazole.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Ketoconazole.
NitrazepamThe serum concentration of Ketoconazole can be increased when it is combined with Nitrazepam.
NitrendipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Nitrendipine.
NitrendipineThe serum concentration of Ketoconazole can be increased when it is combined with Nitrendipine.
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Ketoconazole.
NizatidineThe serum concentration of Ketoconazole can be decreased when it is combined with Nizatidine.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Ketoconazole.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Ketoconazole.
NorethisteroneThe serum concentration of Ketoconazole can be decreased when it is combined with Norethisterone.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Ketoconazole.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Ketoconazole.
OfloxacinKetoconazole may increase the QTc-prolonging activities of Ofloxacin.
OlanzapineThe serum concentration of Ketoconazole can be decreased when it is combined with Olanzapine.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Ketoconazole.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Ketoconazole.
OlaparibThe metabolism of Ketoconazole can be decreased when combined with Olaparib.
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Ketoconazole.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Ketoconazole.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Ketoconazole.
OmeprazoleThe serum concentration of Ketoconazole can be increased when it is combined with Omeprazole.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Ketoconazole.
OndansetronKetoconazole may increase the QTc-prolonging activities of Ondansetron.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Ketoconazole.
OsimertinibThe serum concentration of Ketoconazole can be increased when it is combined with Osimertinib.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Ketoconazole.
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Ketoconazole.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Ketoconazole.
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Ketoconazole.
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Ketoconazole.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Ketoconazole.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Ketoconazole.
P-NitrophenolThe serum concentration of Ketoconazole can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Ketoconazole.
PalbociclibThe serum concentration of Ketoconazole can be increased when it is combined with Palbociclib.
PaliperidoneKetoconazole may increase the QTc-prolonging activities of Paliperidone.
Palmitic AcidThe serum concentration of Ketoconazole can be increased when it is combined with Palmitic Acid.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Ketoconazole.
PanobinostatKetoconazole may increase the QTc-prolonging activities of Panobinostat.
PantoprazoleThe serum concentration of Ketoconazole can be increased when it is combined with Pantoprazole.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Ketoconazole.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Ketoconazole.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Ketoconazole.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Ketoconazole.
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Ketoconazole.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Ketoconazole.
ParoxetineThe serum concentration of Ketoconazole can be increased when it is combined with Paroxetine.
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Ketoconazole.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Ketoconazole.
PentamidineKetoconazole may increase the QTc-prolonging activities of Pentamidine.
PentobarbitalThe metabolism of Ketoconazole can be increased when combined with Pentobarbital.
PerampanelThe metabolism of Perampanel can be decreased when combined with Ketoconazole.
PerflutrenKetoconazole may increase the QTc-prolonging activities of Perflutren.
PergolideThe metabolism of Pergolide can be decreased when combined with Ketoconazole.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Ketoconazole.
PerindoprilThe serum concentration of Ketoconazole can be increased when it is combined with Perindopril.
PermethrinThe metabolism of Permethrin can be decreased when combined with Ketoconazole.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Ketoconazole.
PethidineThe metabolism of Pethidine can be decreased when combined with Ketoconazole.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Ketoconazole.
PhenforminThe metabolism of Phenformin can be decreased when combined with Ketoconazole.
PhenindioneThe serum concentration of Phenindione can be increased when it is combined with Ketoconazole.
PhenobarbitalThe serum concentration of Ketoconazole can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Ketoconazole.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Ketoconazole.
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Ketoconazole.
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Ketoconazole.
PhenytoinThe metabolism of Ketoconazole can be increased when combined with Phenytoin.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Ketoconazole.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Ketoconazole.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Ketoconazole.
PimozideKetoconazole may increase the arrhythmogenic activities of Pimozide.
PimozideThe serum concentration of Ketoconazole can be increased when it is combined with Pimozide.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Ketoconazole.
PinaveriumThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Pinaverium.
PindololThe metabolism of Pindolol can be decreased when combined with Ketoconazole.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Ketoconazole.
PiperazineThe metabolism of Piperazine can be decreased when combined with Ketoconazole.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Ketoconazole.
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Ketoconazole.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Ketoconazole.
Platelet Activating FactorThe serum concentration of Ketoconazole can be decreased when it is combined with Platelet Activating Factor.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Ketoconazole.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Ketoconazole.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Ketoconazole.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Ketoconazole.
PosaconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Posaconazole.
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Ketoconazole.
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Ketoconazole resulting in a loss in efficacy.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Ketoconazole.
PrazepamThe metabolism of Prazepam can be decreased when combined with Ketoconazole.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Ketoconazole.
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Ketoconazole.
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Ketoconazole.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Ketoconazole.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Ketoconazole.
PregabalinThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Pregabalin.
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Ketoconazole.
PrenylamineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Prenylamine.
PrimaquineKetoconazole may increase the QTc-prolonging activities of Primaquine.
PrimidoneThe metabolism of Ketoconazole can be increased when combined with Primidone.
ProbenecidThe serum concentration of Ketoconazole can be increased when it is combined with Probenecid.
ProcainamideThe metabolism of Procainamide can be decreased when combined with Ketoconazole.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Ketoconazole.
ProgesteroneThe therapeutic efficacy of Progesterone can be decreased when used in combination with Ketoconazole.
ProgesteroneThe serum concentration of Ketoconazole can be decreased when it is combined with Progesterone.
ProguanilThe metabolism of Proguanil can be decreased when combined with Ketoconazole.
PromazineKetoconazole may increase the QTc-prolonging activities of Promazine.
PromethazineThe serum concentration of Ketoconazole can be increased when it is combined with Promethazine.
PromethazineThe metabolism of Promethazine can be decreased when combined with Ketoconazole.
PropafenoneThe serum concentration of Ketoconazole can be increased when it is combined with Propafenone.
PropofolThe metabolism of Propofol can be decreased when combined with Ketoconazole.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Ketoconazole.
ProtriptylineThe serum concentration of Ketoconazole can be increased when it is combined with Protriptyline.
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Ketoconazole.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Ketoconazole.
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Ketoconazole.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Ketoconazole.
QuazepamThe metabolism of Quazepam can be decreased when combined with Ketoconazole.
QuercetinThe serum concentration of Ketoconazole can be increased when it is combined with Quercetin.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Ketoconazole.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Ketoconazole.
QuinacrineThe serum concentration of Ketoconazole can be increased when it is combined with Quinacrine.
QuinidineThe metabolism of Quinidine can be decreased when combined with Ketoconazole.
QuinidineThe serum concentration of Ketoconazole can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Quinine can be increased when it is combined with Ketoconazole.
RabeprazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Rabeprazole.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Ketoconazole.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Ketoconazole.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Ketoconazole.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Ketoconazole.
RanolazineThe serum concentration of Ketoconazole can be increased when it is combined with Ranolazine.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Ketoconazole.
ReboxetineThe serum concentration of Ketoconazole can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Ketoconazole.
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Ketoconazole.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Ketoconazole.
repinotanThe metabolism of repinotan can be decreased when combined with Ketoconazole.
ReserpineThe serum concentration of Ketoconazole can be decreased when it is combined with Reserpine.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Ketoconazole.
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Ketoconazole.
RifabutinThe metabolism of Ketoconazole can be increased when combined with Rifabutin.
RifampicinThe serum concentration of Ketoconazole can be decreased when it is combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Ketoconazole.
RifapentineThe metabolism of Ketoconazole can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Ketoconazole.
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Ketoconazole.
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Ketoconazole.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Ketoconazole.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Ketoconazole.
RisedronateThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Risedronate.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Ketoconazole.
RitonavirThe serum concentration of Ketoconazole can be decreased when it is combined with Ritonavir.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Ketoconazole.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Ketoconazole.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Ketoconazole.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Ketoconazole.
RolapitantThe serum concentration of Ketoconazole can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Ketoconazole.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Ketoconazole.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Ketoconazole.
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Ketoconazole.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Ketoconazole.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Ketoconazole.
Roxatidine acetateThe serum concentration of Ketoconazole can be decreased when it is combined with Roxatidine acetate.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Ketoconazole.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Ketoconazole.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Ketoconazole.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Ketoconazole.
SaquinavirKetoconazole may increase the QTc-prolonging activities of Saquinavir.
SaquinavirThe serum concentration of Ketoconazole can be decreased when it is combined with Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Ketoconazole.
ScopolamineThe serum concentration of Ketoconazole can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Ketoconazole can be increased when it is combined with Selegiline.
SelegilineThe metabolism of Selegiline can be decreased when combined with Ketoconazole.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Ketoconazole.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Ketoconazole.
SertindoleThe metabolism of Sertindole can be decreased when combined with Ketoconazole.
SertralineThe serum concentration of Ketoconazole can be increased when it is combined with Sertraline.
SertralineThe metabolism of Sertraline can be decreased when combined with Ketoconazole.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Ketoconazole.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Ketoconazole.
SildenafilThe metabolism of Ketoconazole can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Ketoconazole.
SiltuximabThe serum concentration of Ketoconazole can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Ketoconazole can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Ketoconazole.
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Ketoconazole.
SirolimusThe serum concentration of Ketoconazole can be decreased when it is combined with Sirolimus.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Ketoconazole.
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Ketoconazole.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Ketoconazole.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Ketoconazole.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Ketoconazole.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Ketoconazole.
SotalolKetoconazole may increase the QTc-prolonging activities of Sotalol.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Ketoconazole.
SparteineThe metabolism of Sparteine can be decreased when combined with Ketoconazole.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Ketoconazole.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Ketoconazole.
SpironolactoneThe serum concentration of Ketoconazole can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Ketoconazole can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Ketoconazole can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Ketoconazole can be increased when it is combined with Stiripentol.
StreptozocinThe serum concentration of Ketoconazole can be decreased when it is combined with Streptozocin.
SucralfateSucralfate can cause a decrease in the absorption of Ketoconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Ketoconazole.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Ketoconazole.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Ketoconazole.
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Ketoconazole.
SulfinpyrazoneThe serum concentration of Ketoconazole can be increased when it is combined with Sulfinpyrazone.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Ketoconazole.
SulfisoxazoleKetoconazole may increase the QTc-prolonging activities of Sulfisoxazole.
SulfisoxazoleThe metabolism of Ketoconazole can be decreased when combined with Sulfisoxazole.
SumatriptanThe serum concentration of Ketoconazole can be increased when it is combined with Sumatriptan.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Ketoconazole.
SunitinibThe serum concentration of Ketoconazole can be increased when it is combined with Sunitinib.
SuprofenThe metabolism of Suprofen can be decreased when combined with Ketoconazole.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Ketoconazole.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Ketoconazole.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Ketoconazole.
TacrineThe serum concentration of Ketoconazole can be increased when it is combined with Tacrine.
TacrolimusThe serum concentration of Ketoconazole can be decreased when it is combined with Tacrolimus.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Ketoconazole.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Ketoconazole.
TAK-390MRThe serum concentration of Ketoconazole can be decreased when it is combined with TAK-390MR.
TamoxifenThe serum concentration of Ketoconazole can be decreased when it is combined with Tamoxifen.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Ketoconazole.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Ketoconazole.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Ketoconazole.
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Ketoconazole.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Ketoconazole.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Ketoconazole.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Ketoconazole.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ketoconazole.
TegaserodThe metabolism of Tegaserod can be decreased when combined with Ketoconazole.
TelaprevirThe metabolism of Ketoconazole can be decreased when combined with Telaprevir.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Ketoconazole.
TelavancinKetoconazole may increase the QTc-prolonging activities of Telavancin.
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Ketoconazole.
TelithromycinThe metabolism of Ketoconazole can be decreased when combined with Telithromycin.
TelmisartanThe serum concentration of Ketoconazole can be increased when it is combined with Telmisartan.
TemazepamThe metabolism of Temazepam can be decreased when combined with Ketoconazole.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Ketoconazole.
TeniposideThe metabolism of Teniposide can be decreased when combined with Ketoconazole.
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Ketoconazole.
TerazosinThe serum concentration of Ketoconazole can be increased when it is combined with Terazosin.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Ketoconazole.
TerfenadineKetoconazole may increase the QTc-prolonging activities of Terfenadine.
TerfenadineThe serum concentration of Ketoconazole can be increased when it is combined with Terfenadine.
TesmilifeneThe serum concentration of Ketoconazole can be decreased when it is combined with Tesmilifene.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Ketoconazole.
TestosteroneThe serum concentration of Ketoconazole can be increased when it is combined with Testosterone.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Ketoconazole.
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Ketoconazole.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Ketoconazole.
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Ketoconazole.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Ketoconazole.
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Ketoconazole.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Ketoconazole.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Ketoconazole.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Ketoconazole.
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Ketoconazole resulting in a loss in efficacy.
TicagrelorThe serum concentration of Ketoconazole can be increased when it is combined with Ticagrelor.
TiclopidineThe metabolism of Ketoconazole can be decreased when combined with Ticlopidine.
TimololThe serum concentration of Timolol can be increased when it is combined with Ketoconazole.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Ketoconazole.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Ketoconazole.
TipranavirThe serum concentration of Ketoconazole can be increased when it is combined with Tipranavir.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Ketoconazole.
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Ketoconazole.
TocilizumabThe serum concentration of Ketoconazole can be decreased when it is combined with Tocilizumab.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Ketoconazole.
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Ketoconazole.
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Tolfenamic Acid.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Ketoconazole.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Ketoconazole.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Ketoconazole.
TorasemideThe metabolism of Torasemide can be decreased when combined with Ketoconazole.
ToremifeneThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Toremifene.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Ketoconazole.
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Ketoconazole.
TranilastThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Tranilast.
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Ketoconazole.
TrazodoneThe serum concentration of Ketoconazole can be decreased when it is combined with Trazodone.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Ketoconazole.
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Ketoconazole.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Ketoconazole.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Ketoconazole.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Ketoconazole.
TrifluoperazineThe serum concentration of Ketoconazole can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Ketoconazole can be increased when it is combined with Triflupromazine.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Ketoconazole.
TrimethoprimThe serum concentration of Ketoconazole can be decreased when it is combined with Trimethoprim.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Ketoconazole.
TrimipramineThe serum concentration of Ketoconazole can be increased when it is combined with Trimipramine.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Ketoconazole.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Ketoconazole.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Ketoconazole.
TroleandomycinThe serum concentration of Ketoconazole can be increased when it is combined with Troleandomycin.
UdenafilThe metabolism of Udenafil can be decreased when combined with Ketoconazole.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Ketoconazole.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Ketoconazole.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Ketoconazole.
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Ketoconazole.
ValsartanThe metabolism of Valsartan can be decreased when combined with Ketoconazole.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Ketoconazole.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Ketoconazole.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Ketoconazole.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Ketoconazole.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Ketoconazole.
VenlafaxineThe metabolism of Ketoconazole can be decreased when combined with Venlafaxine.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Ketoconazole.
VerapamilThe metabolism of Ketoconazole can be decreased when combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Ketoconazole.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Ketoconazole.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Ketoconazole.
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Ketoconazole.
VinblastineThe serum concentration of Ketoconazole can be decreased when it is combined with Vinblastine.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Ketoconazole.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Ketoconazole.
VincristineThe serum concentration of Ketoconazole can be decreased when it is combined with Vincristine.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Ketoconazole.
VinorelbineThe serum concentration of Ketoconazole can be increased when it is combined with Vinorelbine.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Ketoconazole.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Ketoconazole.
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Ketoconazole.
VoriconazoleThe metabolism of Ketoconazole can be decreased when combined with Voriconazole.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Ketoconazole.
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Ketoconazole.
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Ketoconazole.
XylometazolineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Xylometazoline.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Ketoconazole.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Ketoconazole.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Ketoconazole.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Ketoconazole.
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Ketoconazole.
ZiconotideThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Ziconotide.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Ketoconazole.
ZileutonThe metabolism of Zileuton can be decreased when combined with Ketoconazole.
ZimelidineThe serum concentration of Ketoconazole can be increased when it is combined with Zimelidine.
ZiprasidoneThe metabolism of Ketoconazole can be decreased when combined with Ziprasidone.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Ketoconazole.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Ketoconazole.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Ketoconazole.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Ketoconazole.
ZuclopenthixolThe metabolism of Zuclopenthixol can be decreased when combined with Ketoconazole.
Food Interactions
  • Avoid alcohol.
  • Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
  • Take with food.

Targets

Kind
Protein
Organism
Yeast
Pharmacological action
yes
Actions
inhibitor
General Function:
Sterol 14-demethylase activity
Specific Function:
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name:
ERG11
Uniprot ID:
P10613
Molecular Weight:
60674.965 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Agut J, Palacin C, Sacristan A, Ortiz JA: Inhibition of ergosterol synthesis by sertaconazole in Candida albicans. Arzneimittelforschung. 1992 May;42(5A):718-20. [PubMed:1627190 ]
  4. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
  5. Agut J, Palacin C, Salgado J, Casas E, Sacristan A, Ortiz JA: Direct membrane-damaging effect of sertaconazole on Candida albicans as a mechanism of its fungicidal activity. Arzneimittelforschung. 1992 May;42(5A):721-4. [PubMed:1627191 ]
  6. Croxtall JD, Plosker GL: Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynaecology. Drugs. 2009;69(3):339-59. doi: 10.2165/00003495-200969030-00009. [PubMed:19275277 ]
  7. Borgers M, Degreef H, Cauwenbergh G: Fungal infections of the skin: infection process and antimycotic therapy. Curr Drug Targets. 2005 Dec;6(8):849-62. [PubMed:16375669 ]
  8. Warrilow AG, Martel CM, Parker JE, Melo N, Lamb DC, Nes WD, Kelly DE, Kelly SL: Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrob Agents Chemother. 2010 Oct;54(10):4235-45. doi: 10.1128/AAC.00587-10. Epub 2010 Jul 12. [PubMed:20625155 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Zinc ion binding
Specific Function:
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Gene Name:
AR
Uniprot ID:
P10275
Molecular Weight:
98987.9 Da
References
  1. Eil C: Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24(8):367-70. [PubMed:1526623 ]
3. 17-hydroxylase 
Kind
Protein
Organism
Human
Pharmacological action
unknown
References
  1. Trachtenberg J, Zadra J: Steroid synthesis inhibition by ketoconazole: sites of action. Clin Invest Med. 1988 Feb;11(1):1-5. [PubMed:2966691 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Steroid hydroxylase activity
Specific Function:
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.
Gene Name:
CYP21A2
Uniprot ID:
P08686
Molecular Weight:
55886.805 Da
References
  1. Trachtenberg J, Zadra J: Steroid synthesis inhibition by ketoconazole: sites of action. Clin Invest Med. 1988 Feb;11(1):1-5. [PubMed:2966691 ]
5. 11-hydroxylase
Kind
Protein
Organism
Human
Pharmacological action
unknown
References
  1. Trachtenberg J, Zadra J: Steroid synthesis inhibition by ketoconazole: sites of action. Clin Invest Med. 1988 Feb;11(1):1-5. [PubMed:2966691 ]
  2. Loose DS, Kan PB, Hirst MA, Marcus RA, Feldman D: Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Invest. 1983 May;71(5):1495-9. [PubMed:6304148 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Oxygen binding
Specific Function:
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Gene Name:
CYP19A1
Uniprot ID:
P11511
Molecular Weight:
57882.48 Da
References
  1. Weber MM, Will A, Adelmann B, Engelhardt D: Effect of ketoconazole on human ovarian C17,20-desmolase and aromatase. J Steroid Biochem Mol Biol. 1991 Feb;38(2):213-8. [PubMed:2004042 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Sakaeda T, Iwaki K, Kakumoto M, Nishikawa M, Niwa T, Jin JS, Nakamura T, Nishiguchi K, Okamura N, Okumura K: Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs. J Pharm Pharmacol. 2005 Jun;57(6):759-64. [PubMed:15969931 ]
  2. Elsherbiny ME, El-Kadi AO, Brocks DR: The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. J Pharm Pharm Sci. 2008;11(1):147-59. [PubMed:18445370 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Elsherbiny ME, El-Kadi AO, Brocks DR: The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. J Pharm Pharm Sci. 2008;11(1):147-59. [PubMed:18445370 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
Specific Function:
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Gene Name:
CYP11A1
Uniprot ID:
P05108
Molecular Weight:
60101.87 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid 11-beta-monooxygenase activity
Specific Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Gene Name:
CYP11B1
Uniprot ID:
P15538
Molecular Weight:
57572.44 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compou...
Gene Name:
CYP1B1
Uniprot ID:
Q16678
Molecular Weight:
60845.33 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Retinoic acid binding
Specific Function:
Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.
Gene Name:
CYP26A1
Uniprot ID:
O43174
Molecular Weight:
56198.11 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sterol 14-demethylase activity
Specific Function:
Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name:
CYP51A1
Uniprot ID:
Q16850
Molecular Weight:
56805.26 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name:
ABCB11
Uniprot ID:
O95342
Molecular Weight:
146405.83 Da
References
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. [PubMed:12739759 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB: Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 2000 Jun;28(6):655-60. [PubMed:10820137 ]
  2. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514 ]
  3. Wang EJ, Lew K, Casciano CN, Clement RP, Johnson WW: Interaction of common azole antifungals with P glycoprotein. Antimicrob Agents Chemother. 2002 Jan;46(1):160-5. [PubMed:11751127 ]
  4. Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. [PubMed:11961113 ]
  5. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
  6. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103 ]
  7. Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. [PubMed:12235267 ]
  8. Dahan A, Sabit H, Amidon GL: The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport. AAPS J. 2009 Jun;11(2):205-13. doi: 10.1208/s12248-009-9092-5. Epub 2009 Mar 25. [PubMed:19319690 ]
  9. Takano M, Hasegawa R, Fukuda T, Yumoto R, Nagai J, Murakami T: Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells. Eur J Pharmacol. 1998 Oct 9;358(3):289-94. [PubMed:9822896 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
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Drug created on June 13, 2005 07:24 / Updated on August 30, 2016 02:12