Antidepressants and the muscarinic acetylcholine receptor.

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Snyder SH, Yamamura HI

Antidepressants and the muscarinic acetylcholine receptor.

Arch Gen Psychiatry. 1977 Feb;34(2):236-9.

PubMed ID

14603 [ View in PubMed

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Abstract

Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones. The relative anticholinergic activities of tricyclic antidepressants have implications for their use in patients who might be affected adversely by anticholinergic effects.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Amitriptyline	Muscarinic acetylcholine receptor (Protein Group)	Protein group	Humans	Unknown	Ligand	Details