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Identification
NameAmitriptyline
Accession NumberDB00321  (APRD00227)
TypeSmall Molecule
GroupsApproved
Description

Amitriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amitriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, amitriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amitriptyline may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use).

Structure
Thumb
Synonyms
10,11-dihydro-5-(gamma-Dimethylaminopropylidene)-5H-dibenzo(a,D)cycloheptene
10,11-dihydro-N,N-Dimethyl-5H-dibenzo(a,D)heptalene-delta(5),gamma-propylamine
3-(10,11-dihydro-5H-Dibenzo(a,D)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
3-(10,11-dihydro-5H-Dibenzo[a,D]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine
5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,D)cycloheptatriene
5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,D)cycloheptene
5-(gamma-Dimethylaminopropylidene)-5H-dibenzo[a,D][1,4]cycloheptadiene
Amitriptilina
Amitriptylin
Amitriptyline
Amitriptylinum
External Identifiers
  • MK 230
  • N 750
  • Ro 4-1575
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Amitriptyline 10 Tabtablet10 mgoralDuchesnay Inc1981-12-312003-07-18Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Amitriptyline 25 Tabtablet25 mgoralDuchesnay Inc1981-12-312003-07-18Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Amitriptyline HCl Tab 25mgtablet25 mgoralD.C. Labs Limited1977-12-312003-07-11Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Amitriptyline HCl Tab 50mgtablet50 mgoralD.C. Labs Limited1977-12-312003-07-11Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Amitriptyline Tablets B.p 25mgtablet25 mgoralClonmel Healthcare Limited1992-12-311996-09-09Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Amitriptyline-10tablet10 mgoralPro Doc Limitee1976-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Amitriptyline-25tablet25 mgoralPro Doc Limitee1976-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Amitriptyline-50tablet50 mgoralPro Doc Limitee1978-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bio-amitriptylinetablet10 mgoralBiomed Pharma2003-04-23Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bio-amitriptylinetablet50 mgoralBiomed Pharma2003-04-23Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bio-amitriptylinetablet25 mgoralBiomed Pharma2003-04-23Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-amitriptylinetablet50 mgoralBiomed Pharma2004-02-062013-08-02Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-amitriptylinetablet25 mgoralBiomed Pharma2004-02-062013-08-02Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-amitriptylinetablet10 mgoralBiomed Pharma2004-02-062013-08-02Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Elaviltablet10 mgoralAa Pharma Inc1975-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Elaviltablet75 mgoralAa Pharma Inc1987-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Elaviltablet50 mgoralAa Pharma Inc1975-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Elaviltablet25 mgoralAa Pharma Inc1975-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Elavil Pamoate Syr 10mg/5mlsyrup2 mgoralMerck Frosst Canada & Cie, Merck Frosst Canada & Co.1968-12-311998-08-14Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Elavil Tablet 10mgtablet10 mgoral1560678 Ontario Inc.1961-12-312003-08-02Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Elavil Tablet 25mgtablet25 mgoral1560678 Ontario Inc.1961-12-312003-08-02Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Elavil Tablet 50mgtablet50 mgoral1560678 Ontario Inc.1964-12-312010-05-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Elavil Tablet 75mgtablet75 mgoral1560678 Ontario Inc.1976-12-312010-05-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Equipto - Amitriptyline External Cream Compounding KitkittopicalAlvix Laboratories, LLC2015-01-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ipg-amitriptylinetablet10 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ipg-amitriptylinetablet75 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ipg-amitriptylinetablet50 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ipg-amitriptylinetablet25 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-amitriptyline Tabletstablet10 mgoralJamp Pharma Corporation2015-01-12Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-amitriptyline Tabletstablet75 mgoralJamp Pharma Corporation2015-01-12Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-amitriptyline Tabletstablet50 mgoralJamp Pharma Corporation2015-01-12Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-amitriptyline Tabletstablet25 mgoralJamp Pharma Corporation2015-01-12Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Levatetablet25 mgoralBiomed Pharma1974-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Levatetablet75 mgoralBiomed Pharma1979-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Levatetablet10 mgoralBiomed Pharma1965-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Levatetablet50 mgoralBiomed Pharma1969-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-amitriptylinetablet75 mgoralMarcan Pharmaceuticals Inc2015-04-27Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-amitriptylinetablet50 mgoralMarcan Pharmaceuticals Inc2015-04-24Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-amitriptylinetablet25 mgoralMarcan Pharmaceuticals Inc2015-04-24Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-amitriptylinetablet10 mgoralMarcan Pharmaceuticals Inc2015-04-24Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Novo-triptyn Tab 10mgtablet10 mgoralNovopharm Limited1972-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Novo-triptyn Tab 25mgtablet25 mgoralNovopharm Limited1972-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Novo-triptyn Tab 50mgtablet50 mgoralNovopharm Limited1972-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-amitriptyline Tabletstablet25 mgoralNu Pharm IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-amitriptyline Tabletstablet10 mgoralNu Pharm IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-amitriptyline Tabletstablet75 mgoralNu Pharm IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-amitriptyline Tabletstablet50 mgoralNu Pharm IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-amitriptylinetablet25 mgoralBiomed Pharma2003-12-112013-08-02Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-amitriptylinetablet10 mgoralBiomed Pharma2003-12-112013-08-02Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-amitriptylinetablet50 mgoralBiomed Pharma2003-12-112013-08-02Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-amitriptyline Tablets 10mgtablet10 mgoralPharmascience Inc1988-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-amitriptyline Tablets 25mgtablet25 mgoralPharmascience Inc1988-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-amitriptyline Tablets 50mgtablet50 mgoralPharmascience Inc1988-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-amitriptylinetablet10 mgoralTeva Canada Limited2014-12-03Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-amitriptylinetablet50 mgoralTeva Canada Limited2014-12-03Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-amitriptylinetablet25 mgoralTeva Canada Limited2014-12-03Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralA S Medication Solutions Llc1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralSTAT Rx USA LLC1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralSTAT Rx USA LLC1977-11-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralRebel Distributors Corp.1977-11-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralDIRECT RX2015-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralDispensing Solutions, Inc.1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralPreferred Pharmaceuticals, Inc.2011-06-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralA S Medication Solutions Llc1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralSun Pharmaceutical Industries, Inc.1987-07-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1977-11-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralMylan Pharmaceuticals Inc.1978-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet100 mg/1oralREMEDYREPACK INC.2011-12-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralAidarex Pharmaceuticals LLC1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet25 mg/1oralbryant ranch prepack2009-10-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralContract Pharmacy Services Pa2010-02-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralGLENVIEW PHARMA INC.1977-11-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralMylan Institutional Inc.1994-02-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralAmerican Health Packaging2015-03-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralC.O. Truxton, Inc.1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralPhysicians Total Care, Inc.1999-09-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralNorthstar Rx LLC2014-12-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralMed Vantx, Inc.1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralPreferred Pharmaceuticals, Inc.2011-06-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralH.J. Harkins Company, Inc.1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralBlenheim Pharmacal, Inc.2013-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated150 mg/1oralQualitest Pharmaceuticals1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralPd Rx Pharmaceuticals, Inc.1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralAccord Healthcare Inc.2014-12-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralA S Medication Solutions Llc1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralbryant ranch prepack1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralContract Pharmacy Services Pa2010-02-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralGLENVIEW PHARMA INC.1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralMylan Institutional Inc.1994-02-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralClinical Solutions Wholesale1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated150 mg/1oralSandoz Inc1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralC.O. Truxton, Inc.1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralPhysicians Total Care, Inc.2003-02-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralNorthstar Rx LLC2014-12-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralREMEDYREPACK INC.2010-12-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralAidarex Pharmaceuticals LLC1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralTYA Pharmaceuticals1977-11-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated150 mg/1oralDispensing Solutions, Inc.1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralH.J. Harkins Company, Inc.1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralREMEDYREPACK INC.2015-06-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralBlenheim Pharmacal, Inc.2013-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralQualitest Pharmaceuticals1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralPd Rx Pharmaceuticals, Inc.1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralAccord Healthcare Inc.2014-12-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1977-11-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralProficient Rx LP2014-12-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralContract Pharmacy Services Pa1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralGLENVIEW PHARMA INC.1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralUnit Dose Services1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralClinical Solutions Wholesale1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralSandoz Inc1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated150 mg/1oralMylan Pharmaceuticals Inc.1978-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralPhysicians Total Care, Inc.1994-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralNorthstar Rx LLC2014-12-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralREMEDYREPACK INC.2011-04-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2010-12-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralAphena Pharma Solutions Tennessee, Llc1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated150 mg/1oralREMEDYREPACK INC.2013-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralREMEDYREPACK INC.2015-06-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralBlenheim Pharmacal, Inc.2013-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralQualitest Pharmaceuticals1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralPd Rx Pharmaceuticals, Inc.1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralAccord Healthcare Inc.2014-12-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-03-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralTYA Pharmaceuticals1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralContract Pharmacy Services Pa2010-02-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralPreferred Pharmaceuticals, Inc.1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralUnit Dose Services1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralClinical Solutions Wholesale1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralSandoz Inc1977-11-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralMylan Pharmaceuticals Inc.1978-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralPhysicians Total Care, Inc.1995-11-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralNorthstar Rx LLC2014-12-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralMedsource Pharmaceuticals2014-12-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet150 mg/1oralREMEDYREPACK INC.2010-12-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralProficient Rx LP1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralREMEDYREPACK INC.2015-03-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralBlenheim Pharmacal, Inc.2013-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralQualitest Pharmaceuticals1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralCardinal Health2011-06-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralAccord Healthcare Inc.2014-12-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-09-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated150 mg/1oralAidarex Pharmaceuticals LLC1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated150 mg/1oralbryant ranch prepack1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralAphena Pharma Solutions Tennessee, Llc1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralREMEDYREPACK INC.2013-06-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralSun Pharmaceutical Industries, Inc.1987-07-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralSandoz Inc1977-11-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralMylan Pharmaceuticals Inc.1978-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralPhysicians Total Care, Inc.1996-06-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralSTAT Rx USA LLC1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralPd Rx Pharmaceuticals, Inc.1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet100 mg/1oralREMEDYREPACK INC.2010-12-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralProficient Rx LP1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralContract Pharmacy Services Pa1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralPreferred Pharmaceuticals, Inc.1977-11-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralUnit Dose Services1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralBlenheim Pharmacal, Inc.2010-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralQualitest Pharmaceuticals1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralCardinal Health2011-06-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralAccord Healthcare Inc.2014-12-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-10-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralAidarex Pharmaceuticals LLC1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralbryant ranch prepack1977-11-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralAphena Pharma Solutions Tennessee, Llc1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralMylan Institutional Inc.1994-12-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralREMEDYREPACK INC.2015-03-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralSandoz Inc1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralMylan Pharmaceuticals Inc.1978-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralA S Medication Solutions Llc1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralSTAT Rx USA LLC2009-11-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralPd Rx Pharmaceuticals, Inc.1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralRebel Distributors Corp.1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralProficient Rx LP1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralContract Pharmacy Services Pa2010-02-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralPreferred Pharmaceuticals, Inc.1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralUnit Dose Services1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated150 mg/1oralSun Pharmaceutical Industries, Inc.1987-07-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralCardinal Health2011-06-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated150 mg/1oralNorthstar Rx LLC2014-12-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-05-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralAidarex Pharmaceuticals LLC1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralbryant ranch prepack1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralContract Pharmacy Services Pa1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralMylan Institutional Inc.1994-02-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralREMEDYREPACK INC.2015-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralBlenheim Pharmacal, Inc.2010-08-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralQualitest Pharmaceuticals1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralA S Medication Solutions Llc1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralSTAT Rx USA LLC1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralDispensing Solutions, Inc.1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralPreferred Pharmaceuticals, Inc.2011-06-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralA S Medication Solutions Llc1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet50 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralSTAT Rx USA LLC1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralSun Pharmaceutical Industries, Inc.1987-07-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralRebel Distributors Corp.1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralA S Medication Solutions Llc1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralSTAT Rx USA LLC1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralSTAT Rx USA LLC1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralRebel Distributors Corp.1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralProficient Rx LP1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralDispensing Solutions, Inc.1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralPreferred Pharmaceuticals, Inc.1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralUnit Dose Services1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralSun Pharmaceutical Industries, Inc.1987-07-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralSandoz Inc1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralMylan Pharmaceuticals Inc.1978-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet10 mg/1oralREMEDYREPACK INC.2012-09-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralAidarex Pharmaceuticals LLC1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralbryant ranch prepack1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralContract Pharmacy Services Pa1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralAvera Mc Kennan Hospital2015-03-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralMylan Institutional Inc.1994-10-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet50 mg/1oralSt. Mary's Medical Park Pharmacy2009-12-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralC.O. Truxton, Inc.1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated150 mg/1oralPhysicians Total Care, Inc.1995-07-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated100 mg/1oralNorthstar Rx LLC2014-12-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralA S Medication Solutions Llc1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated75 mg/1oralLake Erie Medical DBA Quality Care Products LLC1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated25 mg/1oralDispensing Solutions, Inc.1997-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralPreferred Pharmaceuticals, Inc.2011-06-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated50 mg/1oralH.J. Harkins Company, Inc.1977-11-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet25 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralBlenheim Pharmacal, Inc.2011-10-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1977-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated10 mg/1oralSun Pharmaceutical Industries, Inc.1987-07-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Amitriptyline Hydrochloridetablet, film coated150 mg/1oralAccord Healthcare Inc.2014-12-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Apo-amitriptylinetablet75 mgoralApotex Inc2013-06-12Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-amitriptylinetablet50 mgoralApotex Inc2013-06-12Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-amitriptylinetablet25 mgoralApotex Inc2013-06-12Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-amitriptylinetablet10 mgoralApotex Inc2013-06-12Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Over the Counter ProductsNot Available
International Brands
NameCompany
AdeprilTeofarma
AmitrypRaza
ConmitripCondrugs
EndepAlphapharm
FiordaDriburg
KamitrinSaga
LaroxylDeva
LatilinLa Pharmaceuticals
MaxitripInvision
RedomexLundbeck
SarotenLundbeck
SarotexLundbeck
Sarotex RetardLundbeck
SyneudonKrewel Meuselbach
TryptanolMerck Sharp & Dohme
TryptanolSquare
TryptizolAlgorithm
Uxen RetardSanofi-Aventis
Brand mixtures
NameLabellerIngredients
Apo Peram Tab 2-25Apotex Inc
Apo Peram Tab 3-15Apotex Inc
Chlordiazepoxide and Amitriptyline HClPar Pharmaceutical Inc
Chlordiazepoxide and Amitriptyline HydrochlorideMylan Pharmaceuticals Inc.
Elavil Plus TabTriton Pharma Inc
Etrafon 2 10Schering Plough Canada Inc
Etrafon A TabSchering Plough Canada Inc
Etrafon D TabSchering Plough Canada Inc
Etrafon F TabSchering Plough Canada Inc
Perphenazine and Amitriptyline HydrochlorideMylan Pharmaceuticals Inc.
PMS-levazine 2/25 TabPharmascience Inc
PMS-levazine 3/15 TabPharmascience Inc
PMS-levazine 4/25 TabPharmascience Inc
Proavil TabPro Doc Limitee
Sentravil PM-25Physician Therapeutics Llc
Triavil TabMerck Frosst Canada & Cie, Merck Frosst Canada & Co.
Salts
Name/CASStructureProperties
Amitriptyline Hydrochloride
Thumb
  • InChI Key: KFYRPLNVJVHZGT-UHFFFAOYSA-N
  • Monoisotopic Mass: 313.15972748
  • Average Mass: 313.864
DBSALT000009
Amitriptyline Pamoate
ThumbNot applicableDBSALT001193
Categories
UNII1806D8D52K
CAS number50-48-6
WeightAverage: 277.4033
Monoisotopic: 277.183049741
Chemical FormulaC20H23N
InChI KeyInChIKey=KRMDCWKBEZIMAB-UHFFFAOYSA-N
InChI
InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
IUPAC Name
dimethyl(3-{tricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene}propyl)amine
SMILES
CN(C)CCC=C1C2=CC=CC=C2CCC2=CC=CC=C12
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as dibenzocycloheptenes. These are compounds containing a dibenzocycloheptene moiety, which consists of two benzene connected by a cycloheptene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassDibenzocycloheptenes
Sub ClassNot Available
Direct ParentDibenzocycloheptenes
Alternative Parents
Substituents
  • Dibenzocycloheptene
  • Tertiary aliphatic amine
  • Tertiary amine
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Amine
  • Aromatic homopolycyclic compound
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of depression, chronic pain, irritable bowel syndrome, sleep disorders, diabetic neuropathy, agitation and insomnia, and migraine prophylaxis.
PharmacodynamicsAmitriptyline, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. It is extremely sedating, and thus improvement of sleep patterns can be the first benefit of treatment. Amitriptyline exhibits strong anticholinergic activity, cardiovascular effects including orthostatic hypotension, changes in heart rhythm and conduction, and a lowering of the seizure threshold. As with other antidepressants, several weeks of therapy may be required in order to realize the full clinical benefit of amitriptyline. Although not a labelled indication, amitriptyline is widely used in the management of chronic nonmalignant pain (e.g., post-herpetic neuralgia, fibromyalgia).
Mechanism of actionAmitriptyline is metabolized to nortriptyline which inhibits the reuptake of norepinephrine and serotonin almost equally. Amitriptyline inhibits the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. Pharmacologically this action may potentiate or prolong neuronal activity since reuptake of these biogenic amines is important physiologically in terminating transmitting activity. This interference with the reuptake of norepinephrine and/or serotonin is believed by some to underlie the antidepressant activity of amitriptyline.
AbsorptionRapidly and well absorbed following oral administration (bioavailability is 30-60% due to first pass metabolism). Peak plasma concentrations occur 2-12 hours following oral or intramuscular administration.
Volume of distributionNot Available
Protein bindingVery highly protein bound (90% or more) in plasma and tissues
Metabolism

Exclusively hepatic, with first pass effect. Amitriptyline is demethylated in the liver to its primary active metabolite, nortriptyline.

SubstrateEnzymesProduct
Amitriptyline
NortriptylineDetails
Amitriptyline
E-10-HydroxyamitriptylineDetails
E-10-Hydroxyamitriptyline
E-10-HydroxynortriptylineDetails
E-10-Hydroxynortriptyline
Not Available
E-10-HydroxydesmethylnortriptylineDetails
Nortriptyline
E-10-HydroxynortriptylineDetails
Nortriptyline
Not Available
DesmethylnortriptylineDetails
Desmethylnortriptyline
E-10-HydroxydesmethylnortriptylineDetails
Route of eliminationVirtually the entire dose is excreted as glucuronide or sulfate conjugate of metabolites, with little unchanged drug appearing in the urine. 25-50% of a single orally administered dose is excreted in urine as inactive metabolites within 24 hours. Small amounts are excreted in feces via biliary elimination.
Half life10 to 50 hours, with an average of 15 hours
ClearanceNot Available
ToxicityLD50=350 mg/kg (in mice). Symptoms of overdose include abnormally low blood pressure, confusion, convulsions, dilated pupils and other eye problems, disturbed concentration, drowsiness, hallucinations, impaired heart function, rapid or irregular heartbeat, reduced body temperature, stupor, and unresponsiveness or coma. Side effects include: sedation, hypotension, blurred vision, dry mouth, constipation, urinary retention, postural hypotension, tachycardia, hypertension, ECG changes, heart failure, impaired memory and delirium, and precipitation of hypomanic or manic episodes in bipolar depression. Withdrawal symptoms include gastrointestinal disturbances, anxiety, and insomnia.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*4A AllelePoor drug metabolizer, lower dose requirements, higher risk for adverse side effects18070221
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs2032583 Not AvailableC AlleleImproved response to antidepressant medication17913323
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs2032583 Not AvailableA > GIncrease risk of adverse effects22641028
SNP Mediated Adverse Drug Reactions
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeAdverse ReactionReference(s)
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs1045642 Not AvailableT Allele, homozygousPostural hypotension12082591
Cytochrome P450 2C19
Gene symbol: CYP2C19
UniProt: P33261
rs4244285 CYP2C19*2G > AThose with the AA or AG genotype are poor metabolizers of amitriptyline20531370
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*4C > TIncrease risk of side effects and decrease drug metabolism18070221
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*4C > TIncrease risk of side effects and decrease drug metabolism9918137
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9941
Blood Brain Barrier+0.9512
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.7567
P-glycoprotein inhibitor IInhibitor0.8563
P-glycoprotein inhibitor IIInhibitor0.6447
Renal organic cation transporterInhibitor0.7955
CYP450 2C9 substrateNon-substrate0.7826
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.7501
CYP450 1A2 substrateInhibitor0.7324
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.8933
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.9158
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6955
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.8127
BiodegradationNot ready biodegradable0.8727
Rat acute toxicity2.9697 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7531
hERG inhibition (predictor II)Inhibitor0.6767
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Hoffmann la roche inc
  • Watson laboratories inc
  • Astrazeneca pharmaceuticals lp
  • Bristol myers squibb co
  • Warner chilcott div warner lambert co
  • American therapeutics inc
  • Caraco pharmaceutical laboratories ltd
  • Copley pharmaceutical inc
  • Halsey drug co inc
  • Lederle laboratories div american cyanamid co
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Par pharmaceutical inc
  • Pliva inc
  • Purepac pharmaceutical co
  • Roxane laboratories inc
  • Sandoz inc
  • Superpharm corp
  • Teva pharmaceuticals usa inc
  • Ucb inc
  • Usl pharma inc
  • Vangard laboratories inc div midway medical co
  • Vintage pharmaceuticals inc
  • West ward pharmaceutical corp
Packagers
Dosage forms
FormRouteStrength
Tabletoral10 mg/1
Tabletoral100 mg/1
Tabletoral150 mg/1
Tabletoral25 mg/1
Tabletoral50 mg/1
Tablet, film coatedoral10 mg/1
Tablet, film coatedoral100 mg/1
Tablet, film coatedoral150 mg/1
Tablet, film coatedoral25 mg/1
Tablet, film coatedoral50 mg/1
Tablet, film coatedoral75 mg/1
Syruporal2 mg
Kittopical
Tabletoral75 mg
Tabletoral10 mg
Tabletoral25 mg
Tabletoral50 mg
Tabletoral
Tablet, film coatedoral
Kit
Prices
Unit descriptionCostUnit
Amitriptyline hcl powder7.34USD g
Amitriptyline hcl 150 mg tablet1.18USD tablet
Amitriptyline hcl 100 mg tablet0.66USD tablet
Amitriptyline hcl 75 mg tablet0.54USD tablet
Apo-Amitriptyline 75 mg Tablet0.38USD tablet
Amitriptyline hcl 50 mg tablet0.37USD tablet
Amitriptyline hcl 10 mg tablet0.3USD tablet
Apo-Amitriptyline 50 mg Tablet0.25USD tablet
Amitriptyline hcl 25 mg tablet0.21USD tablet
Apo-Amitriptyline 25 mg Tablet0.13USD tablet
Apo-Amitriptyline 10 mg Tablet0.07USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point187-189.5Tristram, E.W. and Tull, R.J.; US. Patent 3,205,264: September 7,1965; assigned to Merck & Co., Inc.
water solubility9.71 mg/L (at 24 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP4.92HANSCH,C ET AL. (1995)
logS-4.46ADME Research, USCD
pKa9.4SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0045 mg/mLALOGPS
logP5.1ALOGPS
logP4.81ChemAxon
logS-4.8ALOGPS
pKa (Strongest Basic)9.76ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area3.24 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity101.51 m3·mol-1ChemAxon
Polarizability33.74 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (7.48 KB)
Spectra
Spectrum TypeDescriptionSplash Key
MSMass Spectrum (Electron Ionization)splash10-z770000000-989cd234a8cdf04c5f69View in MoNA
References
Synthesis Reference

Manfred Durr, Benedikt Gajdos, Klaus-Dieter Gneuss, Ekkehard Harhausen, Jurgen Seidel, “Pharmaceutical amitriptylin oxide preparation and process for its manufacture.” U.S. Patent US4567202, issued January 28, 1986.

US4567202
General References
  1. Otaka M, Jin M, Odashima M, Matsuhashi T, Wada I, Horikawa Y, Komatsu K, Ohba R, Oyake J, Hatakeyama N, Watanabe S: New strategy of therapy for functional dyspepsia using famotidine, mosapride and amitriptyline. Aliment Pharmacol Ther. 2005 Jun;21 Suppl 2:42-6. Pubmed
External Links
ATC CodesN06AA09
AHFS Codes
  • 28:16.04.28
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.6 KB)
Interactions
Drug Interactions
Drug
AbirateroneThe serum concentration of Amitriptyline can be increased when it is combined with Abiraterone.
AcenocoumarolAmitriptyline may increase the anticoagulant activities of Acenocoumarol.
AcepromazineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Acepromazine.
AcetaminophenThe metabolism of Amitriptyline can be increased when combined with Acetaminophen.
AcetophenazineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Acetophenazine.
Acetylsalicylic acidAmitriptyline may increase the antiplatelet activities of Acetylsalicylic acid.
AclidiniumAclidinium may increase the anticholinergic activities of Amitriptyline.
AltretamineAltretamine may increase the orthostatic hypotensive activities of Amitriptyline.
AmisulprideThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Amisulpride.
AmobarbitalThe metabolism of Amitriptyline can be increased when combined with Amobarbital.
AmphetamineAmitriptyline may increase the stimulatory activities of Amphetamine.
ApraclonidineThe therapeutic efficacy of Apraclonidine can be decreased when used in combination with Amitriptyline.
ArformoterolThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Arformoterol.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Amitriptyline.
ArticaineAmitriptyline may increase the activities of Articaine.
AtazanavirThe serum concentration of Amitriptyline can be increased when it is combined with Atazanavir.
AzelastineAmitriptyline may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Amitriptyline.
BatimastatThe serum concentration of Amitriptyline can be increased when it is combined with Batimastat.
BenzphetamineAmitriptyline may increase the stimulatory activities of Benzphetamine.
BenzquinamideThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Benzquinamide.
Botulinum Toxin Type AAmitriptyline may increase the anticholinergic activities of Botulinum Toxin Type A.
Botulinum Toxin Type BAmitriptyline may increase the anticholinergic activities of Botulinum Toxin Type B.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
BuprenorphineAmitriptyline may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
BupropionThe metabolism of Amitriptyline can be decreased when combined with Bupropion.
ButabarbitalThe metabolism of Amitriptyline can be increased when combined with Butabarbital.
ButalbitalThe metabolism of Amitriptyline can be increased when combined with Butalbital.
ButethalThe metabolism of Amitriptyline can be increased when combined with Butethal.
CaffeineThe metabolism of Amitriptyline can be increased when combined with Caffeine.
CarbamazepineThe metabolism of Amitriptyline can be increased when combined with Carbamazepine.
CarphenazineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Carphenazine.
CathinoneAmitriptyline may increase the stimulatory activities of Cathinone.
CelecoxibAmitriptyline may increase the antiplatelet activities of Celecoxib.
ChlormezanoneThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Chlormezanone.
ChlorpromazineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Chlorpromazine.
ChlorpropamideAmitriptyline may increase the hypoglycemic activities of Chlorpropamide.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Chlorprothixene.
CimetidineThe metabolism of Amitriptyline can be decreased when combined with Cimetidine.
Cimetropium BromideAmitriptyline may increase the anticholinergic activities of Cimetropium Bromide.
CinacalcetThe serum concentration of Amitriptyline can be increased when it is combined with Cinacalcet.
CisaprideAmitriptyline may increase the arrhythmogenic activities of Cisapride.
CitalopramThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Citalopram.
ClonidineAmitriptyline may decrease the antihypertensive activities of Clonidine.
ClozapineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Clozapine.
CobicistatThe serum concentration of Amitriptyline can be increased when it is combined with Cobicistat.
DapoxetineThe risk or severity of adverse effects can be increased when Dapoxetine is combined with Amitriptyline.
DarunavirThe serum concentration of Amitriptyline can be increased when it is combined with Darunavir.
DesmopressinThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Desmopressin.
DexmedetomidineAmitriptyline may decrease the antihypertensive activities of Dexmedetomidine.
DexmethylphenidateThe risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Amitriptyline.
DextroamphetamineAmitriptyline may increase the stimulatory activities of Dextroamphetamine.
DiclofenacAmitriptyline may increase the antiplatelet activities of Diclofenac.
DicoumarolAmitriptyline may increase the anticoagulant activities of Dicoumarol.
DiflunisalAmitriptyline may increase the antiplatelet activities of Diflunisal.
DihydrocodeineAmitriptyline may increase the antiplatelet activities of Dihydrocodeine.
DipivefrinThe therapeutic efficacy of Dipivefrin can be decreased when used in combination with Amitriptyline.
DofetilideAmitriptyline may increase the QTc-prolonging activities of Dofetilide.
DopamineAmitriptyline may increase the activities of Dopamine.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
DuloxetineDuloxetine may increase the serotonergic activities of Amitriptyline.
EluxadolineAmitriptyline may increase the activities of Eluxadoline.
EpinephrineAmitriptyline may increase the activities of Epinephrine.
EscitalopramThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Escitalopram.
EthanolAmitriptyline may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EtodolacAmitriptyline may increase the antiplatelet activities of Etodolac.
FencamfamineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Fencamfamine.
FenoprofenAmitriptyline may increase the antiplatelet activities of Fenoprofen.
FloctafenineAmitriptyline may increase the antiplatelet activities of Floctafenine.
FluconazoleAmitriptyline may increase the QTc-prolonging activities of Fluconazole.
FluoxetineThe risk or severity of adverse effects can be increased when Fluoxetine is combined with Amitriptyline.
FlupentixolThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Flupentixol.
FluphenazineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Fluphenazine.
FlurbiprofenAmitriptyline may increase the antiplatelet activities of Flurbiprofen.
FluspirileneThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Fluspirilene.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Fluticasone Propionate.
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Amitriptyline.
FormoterolThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Formoterol.
FosamprenavirThe serum concentration of Amitriptyline can be increased when it is combined with Fosamprenavir.
GliclazideAmitriptyline may increase the hypoglycemic activities of Gliclazide.
GlimepirideAmitriptyline may increase the hypoglycemic activities of Glimepiride.
GlipizideAmitriptyline may increase the hypoglycemic activities of Glipizide.
Glucagon recombinantThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Glucagon recombinant.
GlyburideAmitriptyline may increase the hypoglycemic activities of Glyburide.
GoserelinAmitriptyline may increase the QTc-prolonging activities of Goserelin.
GranisetronGranisetron may increase the serotonergic activities of Amitriptyline.
GuanfacineAmitriptyline may decrease the antihypertensive activities of Guanfacine.
HaloperidolThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Haloperidol.
HeptabarbitalThe metabolism of Amitriptyline can be increased when combined with Heptabarbital.
HexobarbitalThe metabolism of Amitriptyline can be increased when combined with Hexobarbital.
HydrocodoneAmitriptyline may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
IbuprofenAmitriptyline may increase the antiplatelet activities of Ibuprofen.
IcosapentAmitriptyline may increase the antiplatelet activities of Icosapent.
IndacaterolThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Indacaterol.
IndinavirThe serum concentration of Amitriptyline can be increased when it is combined with Indinavir.
IndomethacinAmitriptyline may increase the antiplatelet activities of Indomethacin.
IobenguaneThe therapeutic efficacy of Iobenguane can be decreased when used in combination with Amitriptyline.
Ipratropium bromideIpratropium bromide may increase the anticholinergic activities of Amitriptyline.
IsocarboxazidIsocarboxazid may increase the serotonergic activities of Amitriptyline.
IsoflurophateThe serum concentration of Amitriptyline can be increased when it is combined with Isoflurophate.
ItoprideThe therapeutic efficacy of Itopride can be decreased when used in combination with Amitriptyline.
KetoprofenAmitriptyline may increase the antiplatelet activities of Ketoprofen.
KetorolacAmitriptyline may increase the antiplatelet activities of Ketorolac.
LeuprolideAmitriptyline may increase the QTc-prolonging activities of Leuprolide.
LevonordefrinAmitriptyline may increase the activities of Levonordefrin.
LevothyroxineLevothyroxine may increase the arrhythmogenic activities of Amitriptyline.
LinezolidLinezolid may increase the serotonergic activities of Amitriptyline.
LiothyronineLiothyronine may increase the arrhythmogenic activities of Amitriptyline.
LiotrixLiotrix may increase the arrhythmogenic activities of Amitriptyline.
LisdexamfetamineAmitriptyline may increase the stimulatory activities of Lisdexamfetamine.
LithiumLithium may increase the neurotoxic activities of Amitriptyline.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Amitriptyline.
LoxapineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Loxapine.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Mefenamic acidAmitriptyline may increase the antiplatelet activities of Mefenamic acid.
MeloxicamAmitriptyline may increase the antiplatelet activities of Meloxicam.
MepivacaineAmitriptyline may increase the activities of Mepivacaine.
MesoridazineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Mesoridazine.
MethamphetamineAmitriptyline may increase the stimulatory activities of Methamphetamine.
MethohexitalThe metabolism of Amitriptyline can be increased when combined with Methohexital.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Methotrimeprazine.
MethyldopaAmitriptyline may decrease the antihypertensive activities of Methyldopa.
Methylene blueAmitriptyline may increase the serotonergic activities of Methylene blue.
MethylphenidateThe risk or severity of adverse effects can be increased when Methylphenidate is combined with Amitriptyline.
MetoclopramideThe risk or severity of adverse effects can be increased when Metoclopramide is combined with Amitriptyline.
MetyrosineAmitriptyline may increase the sedative activities of Metyrosine.
MianserinMianserin may increase the anticholinergic activities of Amitriptyline.
MidodrineAmitriptyline may increase the activities of Midodrine.
MifepristoneMifepristone may increase the QTc-prolonging activities of Amitriptyline.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
MirabegronThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Mirabegron.
MoclobemideMoclobemide may increase the serotonergic activities of Amitriptyline.
MolindoneThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Molindone.
MorphineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Morphine.
MoxonidineThe therapeutic efficacy of Moxonidine can be decreased when used in combination with Amitriptyline.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
NabumetoneAmitriptyline may increase the antiplatelet activities of Nabumetone.
NaphazolineAmitriptyline may increase the activities of Naphazoline.
NaproxenAmitriptyline may increase the antiplatelet activities of Naproxen.
NelfinavirThe serum concentration of Amitriptyline can be increased when it is combined with Nelfinavir.
NicorandilAmitriptyline may increase the hypotensive activities of Nicorandil.
NorepinephrineAmitriptyline may increase the activities of Norepinephrine.
OlanzapineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Olanzapine.
OlodaterolThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Olodaterol.
OndansetronThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Ondansetron.
OrciprenalineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Orciprenaline.
OrphenadrineAmitriptyline may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OxaprozinAmitriptyline may increase the antiplatelet activities of Oxaprozin.
OxymetazolineAmitriptyline may increase the activities of Oxymetazoline.
PaliperidoneThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Paliperidone.
PanobinostatThe serum concentration of Amitriptyline can be increased when it is combined with Panobinostat.
ParaldehydeAmitriptyline may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParoxetineThe risk or severity of adverse effects can be increased when Paroxetine is combined with Amitriptyline.
Peginterferon alfa-2bThe serum concentration of Amitriptyline can be decreased when it is combined with Peginterferon alfa-2b.
PentobarbitalThe metabolism of Amitriptyline can be increased when combined with Pentobarbital.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
PerphenazineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Perphenazine.
PhendimetrazineAmitriptyline may increase the stimulatory activities of Phendimetrazine.
PhenelzinePhenelzine may increase the serotonergic activities of Amitriptyline.
PheniramineAmitriptyline may increase the activities of Pheniramine.
PhenobarbitalThe metabolism of Amitriptyline can be increased when combined with Phenobarbital.
PhentermineAmitriptyline may increase the stimulatory activities of Phentermine.
PhenylephrineAmitriptyline may increase the activities of Phenylephrine.
PimozideThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Pimozide.
PiperacetazineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Piperacetazine.
PirbuterolThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Pirbuterol.
PiroxicamAmitriptyline may increase the antiplatelet activities of Piroxicam.
Potassium ChlorideAmitriptyline may increase the ulcerogenic activities of Potassium Chloride.
PramipexoleAmitriptyline may increase the sedative activities of Pramipexole.
PramlintidePramlintide may increase the anticholinergic activities of Amitriptyline.
PrimidoneThe metabolism of Amitriptyline can be increased when combined with Primidone.
ProcarbazineProcarbazine may increase the serotonergic activities of Amitriptyline.
ProchlorperazineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Prochlorperazine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Amitriptyline.
PromazineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Promazine.
PropylhexedrineAmitriptyline may increase the activities of Propylhexedrine.
QuetiapineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Quetiapine.
QuinidineAmitriptyline may increase the QTc-prolonging activities of Quinidine.
RacepinephrineAmitriptyline may increase the activities of Racepinephrine.
RamosetronAmitriptyline may increase the activities of Ramosetron.
RasagilineRasagiline may increase the serotonergic activities of Amitriptyline.
RemoxiprideThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Remoxipride.
ReserpineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Reserpine.
RisperidoneThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Risperidone.
RitonavirThe metabolism of Amitriptyline can be decreased when combined with Ritonavir.
RopiniroleAmitriptyline may increase the sedative activities of Ropinirole.
RotigotineAmitriptyline may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Amitriptyline.
SalbutamolThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Salbutamol.
SalmeterolThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Salmeterol.
SaquinavirThe serum concentration of Amitriptyline can be increased when it is combined with Saquinavir.
SecobarbitalThe metabolism of Amitriptyline can be increased when combined with Secobarbital.
SecretinThe therapeutic efficacy of Secretin can be decreased when used in combination with Amitriptyline.
SelegilineSelegiline may increase the serotonergic activities of Amitriptyline.
SertindoleThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Sertindole.
SertralineThe risk or severity of adverse effects can be increased when Sertraline is combined with Amitriptyline.
SimeprevirThe serum concentration of Amitriptyline can be increased when it is combined with Simeprevir.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
St. John's WortThe metabolism of Amitriptyline can be increased when combined with St. John's Wort.
SulindacAmitriptyline may increase the antiplatelet activities of Sulindac.
SulpirideThe therapeutic efficacy of Sulpiride can be decreased when used in combination with Amitriptyline.
SuvorexantAmitriptyline may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TacrineThe therapeutic efficacy of Amitriptyline can be decreased when used in combination with Tacrine.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Tedizolid PhosphateTedizolid Phosphate may increase the serotonergic activities of Amitriptyline.
TerbinafineThe metabolism of Amitriptyline can be decreased when combined with Terbinafine.
TerbutalineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Terbutaline.
ThalidomideAmitriptyline may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThioridazineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Thioridazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Thiothixene.
Thyroid extractThyroid extract may increase the arrhythmogenic activities of Amitriptyline.
Tiaprofenic acidAmitriptyline may increase the antiplatelet activities of Tiaprofenic acid.
TiclopidineThe metabolism of Amitriptyline can be decreased when combined with Ticlopidine.
TiotropiumAmitriptyline may increase the anticholinergic activities of Tiotropium.
TipranavirThe serum concentration of Amitriptyline can be increased when it is combined with Tipranavir.
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Amitriptyline.
TolazamideAmitriptyline may increase the hypoglycemic activities of Tolazamide.
TolbutamideAmitriptyline may increase the hypoglycemic activities of Tolbutamide.
TolmetinAmitriptyline may increase the antiplatelet activities of Tolmetin.
TopiramateTopiramate may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
TramadolAmitriptyline may increase the neuroexcitatory activities of Tramadol.
TranylcypromineTranylcypromine may increase the serotonergic activities of Amitriptyline.
TrichlormethiazideThe serum concentration of Trichlormethiazide can be increased when it is combined with Amitriptyline.
TrifluoperazineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Trifluoperazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Triflupromazine.
UmeclidiniumUmeclidinium may increase the anticholinergic activities of Amitriptyline.
Valproic AcidThe serum concentration of Amitriptyline can be increased when it is combined with Valproic Acid.
VilanterolThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Vilanterol.
WarfarinAmitriptyline may increase the anticoagulant activities of Warfarin.
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Amitriptyline.
ZiprasidoneThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Ziprasidone.
ZolpidemAmitriptyline may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Zuclopenthixol.
Food Interactions
  • Avoid alcohol.
  • Avoid excessive quantities of coffee or tea (caffeine).
  • Avoid St.John's Wort.
  • Take with food to reduce irritation.

Targets

1. Sodium-dependent noradrenaline transporter

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Sodium-dependent noradrenaline transporter P23975 Details

References:

  1. Vaishnavi SN, Nemeroff CB, Plott SJ, Rao SG, Kranzler J, Owens MJ: Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2. Pubmed
  2. Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. Pubmed

2. Sodium-dependent serotonin transporter

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Sodium-dependent serotonin transporter P31645 Details

References:

  1. Gould GG, Altamirano AV, Javors MA, Frazer A: A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biol Psychiatry. 2006 Mar 1;59(5):408-14. Epub 2005 Sep 2. Pubmed
  2. Troelsen KB, Nielsen EO, Mirza NR: Chronic treatment with duloxetine is necessary for an anxiolytic-like response in the mouse zero maze: the role of the serotonin transporter. Psychopharmacology (Berl). 2005 Oct;181(4):741-50. Epub 2005 Sep 29. Pubmed
  3. Vaishnavi SN, Nemeroff CB, Plott SJ, Rao SG, Kranzler J, Owens MJ: Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2. Pubmed
  4. Ushijima K, Sakaguchi H, Sato Y, To H, Koyanagi S, Higuchi S, Ohdo S: Chronopharmacological study of antidepressants in forced swimming test of mice. J Pharmacol Exp Ther. 2005 Nov;315(2):764-70. Epub 2005 Aug 3. Pubmed
  5. Kalia M: Neurobiological basis of depression: an update. Metabolism. 2005 May;54(5 Suppl 1):24-7. Pubmed
  6. Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. Pubmed
  7. Werling LL, Keller A, Frank JG, Nuwayhid SJ: A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder. Exp Neurol. 2007 Oct;207(2):248-57. Epub 2007 Jun 30. Pubmed

3. 5-hydroxytryptamine receptor 2A

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: antagonist

Components

Name UniProt ID Details
5-hydroxytryptamine receptor 2A P28223 Details

References:

  1. Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. Pubmed

4. 5-hydroxytryptamine receptor 1A

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
5-hydroxytryptamine receptor 1A P08908 Details

References:

  1. Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. Pubmed

5. Delta-type opioid receptor

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Delta-type opioid receptor P41143 Details

References:

  1. Onali P, Dedoni S, Olianas MC: Direct agonist activity of tricyclic antidepressants at distinct opioid receptor subtypes. J Pharmacol Exp Ther. 2010 Jan;332(1):255-65. Epub 2009 Oct 14. Pubmed

6. Kappa-type opioid receptor

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Kappa-type opioid receptor P41145 Details

References:

  1. Onali P, Dedoni S, Olianas MC: Direct agonist activity of tricyclic antidepressants at distinct opioid receptor subtypes. J Pharmacol Exp Ther. 2010 Jan;332(1):255-65. Epub 2009 Oct 14. Pubmed

7. High affinity nerve growth factor receptor

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
High affinity nerve growth factor receptor P04629 Details

References:

  1. Jang SW, Liu X, Chan CB, Weinshenker D, Hall RA, Xiao G, Ye K: Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol. 2009 Jun 26;16(6):644-56. Pubmed

8. BDNF/NT-3 growth factors receptor

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
BDNF/NT-3 growth factors receptor Q16620 Details

References:

  1. Jang SW, Liu X, Chan CB, Weinshenker D, Hall RA, Xiao G, Ye K: Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol. 2009 Jun 26;16(6):644-56. Pubmed

9. Alpha-1A adrenergic receptor

Kind: Protein

Organism: Human

Pharmacological action: no

Actions: antagonist

Components

Name UniProt ID Details
Alpha-1A adrenergic receptor P35348 Details

References:

  1. Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. Pubmed
  2. Nojimoto FD, Mueller A, Hebeler-Barbosa F, Akinaga J, Lima V, Kiguti LR, Pupo AS: The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors. Neuropharmacology. 2010 Jul-Aug;59(1-2):49-57. Epub 2010 Apr 2. Pubmed

10. Alpha-1D adrenergic receptor

Kind: Protein

Organism: Human

Pharmacological action: no

Actions: antagonist

Components

Name UniProt ID Details
Alpha-1D adrenergic receptor P25100 Details

References:

  1. Nojimoto FD, Mueller A, Hebeler-Barbosa F, Akinaga J, Lima V, Kiguti LR, Pupo AS: The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors. Neuropharmacology. 2010 Jul-Aug;59(1-2):49-57. Epub 2010 Apr 2. Pubmed

11. Alpha-2A adrenergic receptor

Kind: Protein

Organism: Human

Pharmacological action: no

Actions: antagonist

Components

Name UniProt ID Details
Alpha-2A adrenergic receptor P08913 Details

References:

  1. Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. Pubmed
  2. Ozdogan UK, Lahdesmaki J, Mansikka H, Scheinin M: Loss of amitriptyline analgesia in alpha 2A-adrenoceptor deficient mice. Eur J Pharmacol. 2004 Feb 6;485(1-3):193-6. Pubmed

12. Histamine H1 receptor

Kind: Protein

Organism: Human

Pharmacological action: no

Actions: antagonist

Components

Name UniProt ID Details
Histamine H1 receptor P35367 Details

References:

  1. Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. Pubmed

13. Muscarinic acetylcholine receptor M1

Kind: Protein

Organism: Human

Pharmacological action: no

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M1 P11229 Details

References:

  1. Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. Pubmed

14. Muscarinic acetylcholine receptor M2

Kind: Protein

Organism: Human

Pharmacological action: no

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M2 P08172 Details

References:

  1. Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. Pubmed

15. Muscarinic acetylcholine receptor M3

Kind: Protein

Organism: Human

Pharmacological action: no

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M3 P20309 Details

References:

  1. Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. Pubmed

16. Muscarinic acetylcholine receptor M4

Kind: Protein

Organism: Human

Pharmacological action: no

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M4 P08173 Details

References:

  1. Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. Pubmed

17. Muscarinic acetylcholine receptor M5

Kind: Protein

Organism: Human

Pharmacological action: no

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M5 P08912 Details

References:

  1. Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. Pubmed

18. Potassium voltage-gated channel subfamily KQT member 2

Kind: Protein

Organism: Human

Pharmacological action: no

Actions: inhibitor

Components

Name UniProt ID Details
Potassium voltage-gated channel subfamily KQT member 2 O43526 Details

References:

  1. Punke MA, Friederich P: Amitriptyline is a potent blocker of human Kv1.1 and Kv7.2/7.3 channels. Anesth Analg. 2007 May;104(5):1256-64, tables of contents. Pubmed

19. Potassium voltage-gated channel subfamily A member 1

Kind: Protein

Organism: Human

Pharmacological action: no

Actions: inhibitor

Components

Name UniProt ID Details
Potassium voltage-gated channel subfamily A member 1 Q09470 Details

References:

  1. Punke MA, Friederich P: Amitriptyline is a potent blocker of human Kv1.1 and Kv7.2/7.3 channels. Anesth Analg. 2007 May;104(5):1256-64, tables of contents. Pubmed

20. Potassium voltage-gated channel subfamily D member 2

Kind: Protein

Organism: Human

Pharmacological action: no

Actions: inhibitor

Components

Name UniProt ID Details
Potassium voltage-gated channel subfamily D member 2 Q9NZV8 Details

References:

  1. Casis O, Sanchez-Chapula JA: Disopyramide, imipramine, and amitriptyline bind to a common site on the transient outward K+ channel. J Cardiovasc Pharmacol. 1998 Oct;32(4):521-6. Pubmed

21. Potassium voltage-gated channel subfamily D member 3

Kind: Protein

Organism: Human

Pharmacological action: no

Actions: inhibitor

Components

Name UniProt ID Details
Potassium voltage-gated channel subfamily D member 3 Q9UK17 Details

References:

  1. Casis O, Sanchez-Chapula JA: Disopyramide, imipramine, and amitriptyline bind to a common site on the transient outward K+ channel. J Cardiovasc Pharmacol. 1998 Oct;32(4):521-6. Pubmed

22. Histamine H2 receptor

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: blocker

Components

Name UniProt ID Details
Histamine H2 receptor P25021 Details

References:

  1. Angus JA, Black JW: Pharmacological assay of cardiac H2-receptor blockade by amitriptyline and lysergic acid diethylamide. Circ Res. 1980 Jun;46(6 Pt 2):I64-9. Pubmed

23. Histamine H4 receptor

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: binder

Components

Name UniProt ID Details
Histamine H4 receptor Q9H3N8 Details

References:

  1. Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R, Rauser L, Lee SP, Lynch KR, Roth BL, O’Dowd BF: Discovery of a novel member of the histamine receptor family. Mol Pharmacol. 2001 Mar;59(3):427-33. Pubmed

24. Sigma non-opioid intracellular receptor 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Sigma non-opioid intracellular receptor 1 Q99720 Details

References:

  1. Villard V, Meunier J, Chevallier N, Maurice T: Pharmacological interaction with the sigma1 (sigma1)-receptor in the acute behavioral effects of antidepressants. J Pharmacol Sci. 2011;115(3):279-92. Pubmed
  2. Werling LL, Keller A, Frank JG, Nuwayhid SJ: A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder. Exp Neurol. 2007 Oct;207(2):248-57. Epub 2007 Jun 30. Pubmed

25. 5-hydroxytryptamine receptor 2C

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: binder

Components

Name UniProt ID Details
5-hydroxytryptamine receptor 2C P28335 Details

References:

  1. Di Matteo V, De Blasi A, Di Giulio C, Esposito E: Role of 5-HT receptors in the control of central dopamine function. Trends Pharmacol Sci. 2001 May;22(5):229-32. Pubmed

26. Alpha-1B adrenergic receptor

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
Alpha-1B adrenergic receptor P35368 Details

References:

  1. Nojimoto FD, Mueller A, Hebeler-Barbosa F, Akinaga J, Lima V, Kiguti LR, Pupo AS: The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors. Neuropharmacology. 2010 Jul-Aug;59(1-2):49-57. doi: 10.1016/j.neuropharm.2010.03.015. Epub 2010 Apr 2. Pubmed

27. 5-hydroxytryptamine receptor 7

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
5-hydroxytryptamine receptor 7 P34969 Details

References:

  1. Lucchelli A, Santagostino-Barbone MG, D’Agostino G, Masoero E, Tonini M: The interaction of antidepressant drugs with enteric 5-HT7 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep;362(3):284-9. Pubmed

28. 5-hydroxytryptamine receptor 1D

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: binder

Components

Name UniProt ID Details
5-hydroxytryptamine receptor 1D P28221 Details

References:

  1. Werling LL, Keller A, Frank JG, Nuwayhid SJ: A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder. Exp Neurol. 2007 Oct;207(2):248-57. Epub 2007 Jun 30. Pubmed

29. Mu-type opioid receptor

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: binder

Components

Name UniProt ID Details
Mu-type opioid receptor P35372 Details

References:

  1. Wahlstrom A, Lenhammar L, Ask B, Rane A: Tricyclic antidepressants inhibit opioid receptor binding in human brain and hepatic morphine glucuronidation. Pharmacol Toxicol. 1994 Jul;75(1):23-7. Pubmed
  2. Hamon M, Gozlan H, Bourgoin S, Benoliel JJ, Mauborgne A, Taquet H, Cesselin F, Mico JA: Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline. Neuropharmacology. 1987 Jun;26(6):531-9. Pubmed

30. 5-hydroxytryptamine receptor 1B

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: binder

Components

Name UniProt ID Details
5-hydroxytryptamine receptor 1B P28222 Details

References:

  1. Werling LL, Keller A, Frank JG, Nuwayhid SJ: A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder. Exp Neurol. 2007 Oct;207(2):248-57. Epub 2007 Jun 30. Pubmed

31. 5-hydroxytryptamine receptor 6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
5-hydroxytryptamine receptor 6 P50406 Details

References:

  1. Kohen R, Metcalf MA, Khan N, Druck T, Huebner K, Lachowicz JE, Meltzer HY, Sibley DR, Roth BL, Hamblin MW: Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor. J Neurochem. 1996 Jan;66(1):47-56. Pubmed
  2. Sebben M, Ansanay H, Bockaert J, Dumuis A: 5-HT6 receptors positively coupled to adenylyl cyclase in striatal neurones in culture. Neuroreport. 1994 Dec 20;5(18):2553-7. Pubmed

32. Potassium voltage-gated channel subfamily KQT member 3

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Potassium voltage-gated channel subfamily KQT member 3 O43525 Details

References:

  1. Punke MA, Friederich P: Amitriptyline is a potent blocker of human Kv1.1 and Kv7.2/7.3 channels. Anesth Analg. 2007 May;104(5):1256-64, tables of contents. Pubmed

33. Beta adrenergic receptor

Kind: Protein group

Organism: Human

Pharmacological action: unknown

Actions: binder

Components

Name UniProt ID Details
Beta-1 adrenergic receptor P08588 Details
Beta-2 adrenergic receptor P07550 Details
Beta-3 adrenergic receptor P13945 Details

References:

  1. Werling LL, Keller A, Frank JG, Nuwayhid SJ: A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder. Exp Neurol. 2007 Oct;207(2):248-57. Epub 2007 Jun 30. Pubmed

Enzymes

1. Cytochrome P450 2D6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Baumann P: Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet. 1996 Dec;31(6):444-69. Pubmed
  2. Wen B, Ma L, Zhu M: Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67. Epub 2008 Feb 14. Pubmed
  3. Ghahramani P, Ellis SW, Lennard MS, Ramsay LE, Tucker GT: Cytochromes P450 mediating the N-demethylation of amitriptyline. Br J Clin Pharmacol. 1997 Feb;43(2):137-44. Pubmed
  4. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed
  5. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  6. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  7. Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. Pubmed

2. Cytochrome P450 1A2

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 1A2 P05177 Details

References:

  1. Wen B, Ma L, Zhu M: Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67. Epub 2008 Feb 14. Pubmed
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed
  3. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  4. Information Hyperlinked Over Proteins (iHOP) – Website
  5. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  6. Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. Pubmed

3. Cytochrome P450 2C19

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C19 P33261 Details

References:

  1. Shin JG, Park JY, Kim MJ, Shon JH, Yoon YR, Cha IJ, Lee SS, Oh SW, Kim SW, Flockhart DA: Inhibitory effects of tricyclic antidepressants (TCAs) on human cytochrome P450 enzymes in vitro: mechanism of drug interaction between TCAs and phenytoin. Drug Metab Dispos. 2002 Oct;30(10):1102-7. Pubmed
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed
  3. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  5. Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. Pubmed

4. Cytochrome P450 2C9

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C9 P11712 Details

References:

  1. Ghahramani P, Ellis SW, Lennard MS, Ramsay LE, Tucker GT: Cytochromes P450 mediating the N-demethylation of amitriptyline. Br J Clin Pharmacol. 1997 Feb;43(2):137-44. Pubmed
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed
  3. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  5. Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. Pubmed

5. Cytochrome P450 3A4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Wen B, Ma L, Zhu M: Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67. Epub 2008 Feb 14. Pubmed
  2. Ghahramani P, Ellis SW, Lennard MS, Ramsay LE, Tucker GT: Cytochromes P450 mediating the N-demethylation of amitriptyline. Br J Clin Pharmacol. 1997 Feb;43(2):137-44. Pubmed
  3. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  5. Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. Pubmed

6. Cytochrome P450 3A5

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A5 P20815 Details

References:

  1. Wen B, Ma L, Zhu M: Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67. Epub 2008 Feb 14. Pubmed

7. Cytochrome P450 2B6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2B6 P20813 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  2. Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. Pubmed

8. Cytochrome P450 2C8

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C8 P10632 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  2. Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. Pubmed

9. Cytochrome P450 2E1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2E1 P05181 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

Carriers

1. Serum albumin

Kind: Protein

Organism: Human

Pharmacological action: no

Components

Name UniProt ID Details
Serum albumin P02768 Details

References:

  1. Brinkschulte M, Breyer-Pfaff U: The contribution of alpha 1-acid glycoprotein, lipoproteins, and albumin to the plasma binding of perazine, amitriptyline, and nortriptyline in healthy man. Naunyn Schmiedebergs Arch Pharmacol. 1980 Oct;314(1):61-6. Pubmed
  2. Banerjee T, Singh SK, Kishore N: Binding of naproxen and amitriptyline to bovine serum albumin: biophysical aspects. J Phys Chem B. 2006 Nov 30;110(47):24147-56. Pubmed

2. Alpha-1-acid glycoprotein 1

Kind: Protein

Organism: Human

Pharmacological action: no

Components

Name UniProt ID Details
Alpha-1-acid glycoprotein 1 P02763 Details

References:

  1. Brinkschulte M, Breyer-Pfaff U: The contribution of alpha 1-acid glycoprotein, lipoproteins, and albumin to the plasma binding of perazine, amitriptyline, and nortriptyline in healthy man. Naunyn Schmiedebergs Arch Pharmacol. 1980 Oct;314(1):61-6. Pubmed
  2. Ferry DG, Caplan NB, Cubeddu LX: Interaction between antidepressants and alpha 1-adrenergic receptor antagonists on the binding to alpha 1-acid glycoprotein. J Pharm Sci. 1986 Feb;75(2):146-9. Pubmed

Transporters

1. Multidrug resistance protein 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. Pubmed
  2. Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:09