Clodronate inhibits PGE(2) production in compressed periodontal ligament cells.

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Liu L, Igarashi K, Kanzaki H, Chiba M, Shinoda H, Mitani H

Clodronate inhibits PGE(2) production in compressed periodontal ligament cells.

J Dent Res. 2006 Aug;85(8):757-60.

PubMed ID

16861295 [ View in PubMed

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Abstract

Periodontal ligament (PDL) cells play an essential role in orthodontic tooth movement. We recently reported that clodronate, a non-N-containing bisphosphonate, strongly inhibited tooth movement in rats, and thus could be a useful adjunct for orthodontic treatment. However, it is not clear how clodronate affects the responses of PDL cells to orthodontic force. In this study, we hypothesized that clodronate prevents the mechanical stress-induced production of prostaglandin E(2) (PGE(2)), interleukin-1beta (IL-1beta), and nitric oxide (NO) in human PDL cells. A compressive stimulus caused a striking increase in PGE(2) production, while the responses of IL-1beta and NO were less marked. Clodronate concentration-dependently inhibited the stress-induced production of PGE(2). Clodronate also strongly inhibited stress-induced gene expression for COX-2 and RANKL. These results suggest that the inhibitory effects of clodronate on tooth movement and osteoclasts may be due, at least in part, to the inhibition of COX-2-dependent PGE(2) production and RANKL expression in PDL cells.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Clodronic acid	Prostaglandin G/H synthase 2	Protein	Humans	Unknown	Inhibitor	Details