Signaling and regulation of G protein-coupled receptors in airway smooth muscle.

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Billington CK, Penn RB

Signaling and regulation of G protein-coupled receptors in airway smooth muscle.

Respir Res. 2003;4:2. Epub 2003 Mar 14.

PubMed ID
12648290 [ View in PubMed
]
Abstract

Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive overview of the GPCRs that have been identified in ASM cells, and discuss the extent to which signaling via these GPCRs has been characterized and linked to distinct ASM functions. In addition, we examine the role of GPCR signaling and its regulation in asthma and asthma treatment, and suggest an integrative model whereby an imbalance of GPCR-derived signals in ASM cells contributes to the asthmatic state.

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