The pharmacological basis and pathophysiological significance of the heart rate-lowering property of diltiazem.
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O'Connor SE, Grosset A, Janiak P
The pharmacological basis and pathophysiological significance of the heart rate-lowering property of diltiazem.
Fundam Clin Pharmacol. 1999;13(2):145-53.
- PubMed ID
- 10226758 [ View in PubMed]
- Abstract
The calcium channel blocker diltiazem lowers heart rate in man and this property probably contributes to its clinical effectiveness in ischaemic heart disease and hypertension. This review examines the pharmacological basis of diltiazem's heart rate-lowering activity and considers its pathophysiological significance. The points discussed include the potent direct inhibitory effect of diltiazem on the sinus node and the frequency-dependence of this action. In addition, the well-balanced tissue selectivity profile of diltiazem and its ability to modulate cardiac reflex responsiveness contribute by counteracting the potential for reflex tachycardia.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Diltiazem Voltage-dependent L-type calcium channel subunit alpha-1C Protein Humans YesBlockerDetails