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Identification
NameDiltiazem
Accession NumberDB00343  (APRD00473)
TypeSmall Molecule
GroupsApproved
Description

A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. It is also teratogenic. [PubChem]

Structure
Thumb
Synonyms
SynonymLanguageCode
(+)-cis-5-[2-(dimethylamino)Ethyl]-2,3-dihydro-3-hydroxy-2-(P-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate esterNot AvailableNot Available
(2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-oneNot AvailableNot Available
(2S,3S)-5-(2-(dimethylamino)Ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetateNot AvailableNot Available
Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl esterNot AvailableNot Available
DiltiazemNot AvailableNot Available
DiltiazemumNot AvailableNot Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Cardizemtablet, coated30 mgoralValeant Pharmaceuticals North America LLC2010-12-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizemtablet, coated60 mgoralValeant Pharmaceuticals North America LLC2010-12-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizemtablet, coated120 mgoralValeant Pharmaceuticals North America LLC2010-12-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralAphena Pharma Solutions Tennessee, Llc2009-09-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralAphena Pharma Solutions Tennessee, Llc2009-09-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mgoralAphena Pharma Solutions Tennessee, Llc2009-09-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mgoralAphena Pharma Solutions Tennessee, Llc2009-09-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralAphena Pharma Solutions Tennessee, Llc2009-09-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralREMEDYREPACK INC.2011-08-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralPhysicians Total Care, Inc.2000-11-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralPhysicians Total Care, Inc.2000-05-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralPhysicians Total Care, Inc.2000-05-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mgoralPhysicians Total Care, Inc.2004-02-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mgoralPhysicians Total Care, Inc.2005-01-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizemcapsule180 mgoralCardinal Health2001-04-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizemcapsule240 mgoralCardinal Health2001-04-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralbryant ranch prepack2009-09-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mgoralbryant ranch prepack2009-09-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralCarilion Materials Management2009-09-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralCarilion Materials Management2009-09-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralCarilion Materials Management2009-09-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralCarilion Materials Management2009-09-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mgoralCarilion Materials Management2009-09-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release180 mgoralOceanside Pharmaceuticals2014-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release240 mgoralOceanside Pharmaceuticals2014-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release300 mgoralOceanside Pharmaceuticals2014-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release360 mgoralOceanside Pharmaceuticals2014-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release420 mgoralOceanside Pharmaceuticals2014-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tiazaccapsule (extended release)120 mgoralValeant Canada Lp Valeant Canada S.E.C.Not AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tiazaccapsule (extended release)180 mgoralValeant Canada Lp Valeant Canada S.E.C.Not AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tiazaccapsule (extended release)240 mgoralValeant Canada Lp Valeant Canada S.E.C.Not AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tiazaccapsule (extended release)300 mgoralValeant Canada Lp Valeant Canada S.E.C.Not AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tiazaccapsule (extended release)360 mgoralValeant Canada Lp Valeant Canada S.E.C.Not AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Diltiazem Hydrochloridetablet, film coated30 mgoralTeva Pharmaceuticals USA Inc1995-12-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralTeva Pharmaceuticals USA Inc1995-12-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated90 mgoralTeva Pharmaceuticals USA Inc1995-12-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mgoralTeva Pharmaceuticals USA Inc1995-12-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralTEVA Pharmaceuticals USA Inc.1999-12-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralTEVA Pharmaceuticals USA Inc.1999-12-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralTEVA Pharmaceuticals USA Inc.1999-12-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mgoralTEVA Pharmaceuticals USA Inc.1999-12-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mgoralKAISER FOUNDATION HOSPITALS2012-02-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralActavis Elizabeth LLC2012-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralActavis Elizabeth LLC2012-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralActavis Elizabeth LLC2012-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mgoralActavis Elizabeth LLC2012-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mgoralActavis Elizabeth LLC2012-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release420 mgoralActavis Elizabeth LLC2012-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralActavis Elizabeth LLC1999-12-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralActavis Elizabeth LLC1999-12-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mgoralActavis Elizabeth LLC1999-12-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralActavis Elizabeth LLC1999-12-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mgoralActavis Elizabeth LLC2013-11-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mgoralMylan Pharmaceuticals Inc.1992-03-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralMylan Pharmaceuticals Inc.1992-03-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated90 mgoralMylan Pharmaceuticals Inc.1992-03-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mgoralMylan Pharmaceuticals Inc.1992-03-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralMylan Pharmaceuticals Inc.2012-06-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralMylan Pharmaceuticals Inc.2012-06-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralMylan Pharmaceuticals Inc.2012-06-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release60 mgoralMylan Pharmaceuticals Inc.1997-05-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release90 mgoralMylan Pharmaceuticals Inc.1997-05-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralMylan Pharmaceuticals Inc.1997-05-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection, solution5 mg/mLintravenousHospira, Inc.2012-04-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridepowder, for solution100 mgintravenousHospira, Inc.2011-10-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-12-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-12-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated90 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-12-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-12-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection5 mg/mLintravenousWest Ward Pharmaceutical Corp.2008-12-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection5 mg/mLintravenousWest Ward Pharmaceutical Corp.2008-12-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection5 mg/mLintravenousWest Ward Pharmaceutical Corp.2008-12-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralSandoz Inc2012-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralSandoz Inc2012-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralSandoz Inc2012-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mgoralSandoz Inc2012-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mgoralSandoz Inc2012-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release420 mgoralSandoz Inc2012-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralMajor Pharmaceuticals2010-05-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection, solution5 mg/mLintravenousBaxter Healthcare Corporation2010-07-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection5 mg/mLintravenousAkorn, Inc.2013-11-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection5 mg/mLintravenousAkorn, Inc.2013-03-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection5 mg/mLintravenousAkorn, Inc.2006-12-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralRebel Distributors Corp1999-12-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralRebel Distributors Corp1999-12-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralRebel Distributors Corp1992-11-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mgoralRebel Distributors Corp1992-11-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralRebel Distributors Corp1999-12-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralREMEDYREPACK INC.2013-03-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralAidarex Pharmaceuticals LLC1995-12-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralAidarex Pharmaceuticals LLC1999-12-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralAidarex Pharmaceuticals LLC1999-12-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mgoralAidarex Pharmaceuticals LLC1995-12-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralLake Erie Medical DBA Quality Care Products LLC1995-12-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mgoralLake Erie Medical DBA Quality Care Products LLC1995-12-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mgoralLake Erie Medical DBA Quality Care Products LLC1995-12-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralAv Kare, Inc.2014-01-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralAv Kare, Inc.2014-01-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralAv Kare, Inc.2014-06-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mgoralAv Kare, Inc.2014-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralSun Pharma Global FZE2010-11-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralSun Pharma Global FZE2010-11-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralSun Pharma Global FZE2010-11-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mgoralSun Pharma Global FZE2010-11-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mgoralSun Pharma Global FZE2010-11-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralSun Pharma Global FZE2011-10-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralSun Pharma Global FZE2011-10-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralSun Pharma Global FZE2011-10-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mgoralSun Pharma Global FZE2011-10-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mgoralSun Pharma Global FZE2011-10-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule180 mgoralREMEDYREPACK INC.2013-07-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule180 mgoralREMEDYREPACK INC.2011-08-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralREMEDYREPACK INC.2011-04-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralREMEDYREPACK INC.2011-03-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralREMEDYREPACK INC.2011-06-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet30 mgoralREMEDYREPACK INC.2011-10-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet30 mgoralREMEDYREPACK INC.2012-08-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralREMEDYREPACK INC.2013-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralREMEDYREPACK INC.2013-12-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralREMEDYREPACK INC.2011-09-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralREMEDYREPACK INC.2011-11-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralUnit Dose Services1995-12-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralUnit Dose Services1999-12-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mgoralMylan Institutional Inc.1996-03-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralMylan Institutional Inc.1996-03-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated90 mgoralMylan Institutional Inc.1996-03-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release60 mgoralMylan Institutional Inc.1999-12-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release90 mgoralMylan Institutional Inc.1999-12-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralMylan Institutional Inc.1999-12-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralMylan Institutional Inc.2000-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralMylan Institutional Inc.2000-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralMylan Institutional Inc.2000-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralREMEDYREPACK INC.2013-03-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralREMEDYREPACK INC.2012-09-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralAidarex Pharmaceuticals LLC2011-10-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mgoralState of Florida DOH Central Pharmacy2013-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralA S Medication Solutions Llc1995-12-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralPhysicians Total Care, Inc.2005-03-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated90 mgoralPhysicians Total Care, Inc.1996-05-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mgoralPhysicians Total Care, Inc.1995-04-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mgoralPhysicians Total Care, Inc.2011-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralPhysicians Total Care, Inc.2004-05-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralPhysicians Total Care, Inc.2009-12-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralPhysicians Total Care, Inc.2004-06-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralCardinal Health2010-01-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralCardinal Health2010-01-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralCardinal Health2010-01-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mgoralCardinal Health1995-12-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralCardinal Health1995-12-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralCardinal Health2011-07-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated90 mgoralCardinal Health1992-11-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mgoralCardinal Health1992-11-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralCardinal Health1992-11-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralCardinal Health2007-07-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralPd Rx Pharmaceuticals, Inc.2011-11-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mgoralPd Rx Pharmaceuticals, Inc.2011-11-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralPd Rx Pharmaceuticals, Inc.2011-09-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection, solution5 mg/mLintravenousBedford Laboratories1996-02-282015-04-30Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Dilt-cdcapsule120 mgoralApotex Corp.2006-08-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Dilt-cdcapsule180 mgoralApotex Corp.2006-08-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Dilt-cdcapsule240 mgoralApotex Corp.2006-08-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Dilt-cdcapsule300 mgoralApotex Corp.2006-08-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralApotex Corp.2001-07-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralApotex Corp.2001-07-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralApotex Corp.2001-07-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltzaccapsule, extended release120 mgoralApotex Corp.2009-02-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltzaccapsule, extended release180 mgoralApotex Corp.2009-02-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltzaccapsule, extended release240 mgoralApotex Corp.2009-02-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltzaccapsule, extended release300 mgoralApotex Corp.2009-02-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltzaccapsule, extended release360 mgoralApotex Corp.2009-02-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralSt Marys Medical Park Pharmacy2013-07-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralSt Marys Medical Park Pharmacy2014-08-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cartia XTcapsule, extended release120 mgoralWatson Pharma, Inc.1999-06-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cartia XTcapsule, extended release180 mgoralWatson Pharma, Inc.1999-06-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cartia XTcapsule, extended release240 mgoralWatson Pharma, Inc.1999-06-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cartia XTcapsule, extended release300 mgoralWatson Pharma, Inc.1999-06-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release120 mgoralWatson Pharma, Inc.2010-03-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release180 mgoralWatson Pharma, Inc.2010-03-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release240 mgoralWatson Pharma, Inc.2010-03-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release300 mgoralWatson Pharma, Inc.2010-03-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release360 mgoralWatson Pharma, Inc.2010-03-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release420 mgoralWatson Pharma, Inc.2010-03-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralAmerican Health Packaging2010-01-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralAmerican Health Packaging2010-01-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralAmerican Health Packaging2010-01-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mgoralAmerican Health Packaging2010-01-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralbryant ranch prepack1999-12-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralbryant ranch prepack1995-12-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralbryant ranch prepack2010-11-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, coated30 mgoralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-08-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, coated60 mgoralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-08-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-05-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-07-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-05-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-06-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-05-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-07-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralDispensing Solutions, Inc.1999-12-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralDispensing Solutions, Inc.1999-12-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralDispensing Solutions, Inc.1999-12-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mgoralOceanside Pharmaceuticals1999-12-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mgoralOceanside Pharmaceuticals1999-12-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralOceanside Pharmaceuticals1999-12-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mgoralOceanside Pharmaceuticals1999-12-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mgoralPreferred Pharmaceuticals, Inc.2011-03-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mgoralMc Kesson Contract Packaging2011-11-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mgoralMc Kesson Contract Packaging2011-09-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter ProductsNot Available
International Brands
NameCompany
AcalixRoemmers
AdizemMundipharma
AltiazemLusofarmaco
AnohealNot Available
CalcicardNot Available
CartiaNot Available
DilacorNot Available
Dilacor-XRWatson
DilcontinModi-Mundipharma
DilreneSanofi
Diltia XTNot Available
DilticardIntra
DilzemPfizer
HerbesserMitsubishi Tanabe
Incoril APBago
MasdilEsteve
SurazemNot Available
TAZTIANot Available
ViazemBiovail
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Diltiazem hydrochloride
ThumbNot applicableDBSALT000865
CategoriesNot Available
CAS number42399-41-7
WeightAverage: 414.518
Monoisotopic: 414.16132802
Chemical FormulaC22H26N2O4S
InChI KeyHSUGRBWQSSZJOP-RTWAWAEBSA-N
InChI
InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
IUPAC Name
(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
SMILES
COC1=CC=C(C=C1)[C@@H]1SC2=CC=CC=C2N(CCN(C)C)C(=O)[C@@H]1OC(C)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzothiazepines. These are organic compounds containing a benzene fused to a thiazepine ring (a seven-membered ring with a nitrogen atom and a sulfur atom replacing two carbon atoms).
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzothiazepines
Sub ClassNot Available
Direct ParentBenzothiazepines
Alternative Parents
Substituents
  • Benzothiazepine
  • Methoxybenzene
  • Phenol ether
  • Anisole
  • Alkylarylthioether
  • Alkyl aryl ether
  • Benzenoid
  • Monocyclic benzene moiety
  • Acetate salt
  • Tertiary carboxylic acid amide
  • Tertiary aliphatic amine
  • Tertiary amine
  • Lactam
  • Carboxylic acid ester
  • Carboxamide group
  • Azacycle
  • Thioether
  • Ether
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
  • 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate (CHEBI:101278 )
Pharmacology
IndicationFor the treatment of Hypertension
PharmacodynamicsDiltiazem, a benzothiazepine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Diltiazem is a non-dihydropyridine (DHP)member of the calcium channel blocker class, along with Verapamil. Diltiazem is similar to other peripheral vasodilators. Diltiazem inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Mechanism of actionPossibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, diltiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.
AbsorptionDiltiazem is well absorbed from the gastrointestinal tract but undergoes substantial hepatic first-pass effect.
Volume of distributionNot Available
Protein binding70%-80%
Metabolism

Diltiazem is metabolized by and acts as an inhibitor of the CYP3A4 enzyme.

SubstrateEnzymesProduct
Diltiazem
N-DesmethyldiltiazemDetails
Route of eliminationNot Available
Half life3.0 - 4.5 hours
ClearanceNot Available
ToxicityLD50=740mg/kg (orally in mice)
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Diltiazem Action PathwayDrug actionSMP00359
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588
rs1801253 Not AvailableG > CBetter response to drug therapy22192668
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9788
Blood Brain Barrier+0.506
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.8645
P-glycoprotein inhibitor IInhibitor0.8675
P-glycoprotein inhibitor IIInhibitor0.8997
Renal organic cation transporterNon-inhibitor0.7634
CYP450 2C9 substrateNon-substrate0.699
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 substrateNon-inhibitor0.9071
CYP450 2D6 substrateNon-inhibitor0.9231
CYP450 2C19 substrateNon-inhibitor0.9025
CYP450 3A4 substrateInhibitor0.796
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8681
Ames testNon AMES toxic0.6985
CarcinogenicityNon-carcinogens0.8772
BiodegradationNot ready biodegradable0.9951
Rat acute toxicity2.4130 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9971
hERG inhibition (predictor II)Inhibitor0.7723
Pharmacoeconomics
Manufacturers
  • Biovail laboratories inc
  • Watson laboratories inc florida
  • Watson laboratories inc
  • Apotex inc
  • Actavis elizabeth llc
  • Kv pharmaceutical co
  • Mylan pharmaceuticals inc
  • Teva pharmaceuticals usa inc
  • Apotex inc etobicoke site
  • Biovail corp international
  • Biovail laboratories international srl
  • Apotex inc richmond hill
  • Baxter healthcare corp anesthesia and critical care
  • Bedford laboratories div ben venue laboratories inc
  • Hospira inc
  • International medication systems ltd
  • Taylor pharmacal co
  • Teva parenteral medicines inc
  • Apothecon inc div bristol myers squibb
  • Dava pharmaceuticals inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Teva pharmaceuticals usa
  • Merck and co inc
Packagers
Dosage forms
FormRouteStrength
Capsuleoral120 mg
Capsuleoral180 mg
Capsuleoral240 mg
Capsuleoral300 mg
Capsule (extended release)oral120 mg
Capsule (extended release)oral180 mg
Capsule (extended release)oral240 mg
Capsule (extended release)oral300 mg
Capsule (extended release)oral360 mg
Capsule, extended releaseoral120 mg
Capsule, extended releaseoral180 mg
Capsule, extended releaseoral240 mg
Capsule, extended releaseoral300 mg
Capsule, extended releaseoral360 mg
Capsule, extended releaseoral420 mg
Capsule, extended releaseoral60 mg
Capsule, extended releaseoral90 mg
Injectionintravenous5 mg/mL
Injection, solutionintravenous5 mg/mL
Powder, for solutionintravenous100 mg
Tabletoral30 mg
Tablet, coatedoral120 mg
Tablet, coatedoral30 mg
Tablet, coatedoral60 mg
Tablet, extended releaseoral120 mg
Tablet, extended releaseoral180 mg
Tablet, extended releaseoral240 mg
Tablet, extended releaseoral300 mg
Tablet, extended releaseoral360 mg
Tablet, extended releaseoral420 mg
Tablet, film coatedoral120 mg
Tablet, film coatedoral30 mg
Tablet, film coatedoral60 mg
Tablet, film coatedoral90 mg
Prices
Unit descriptionCostUnit
Cormax 0.05% Solution 50ml Bottle81.6USD bottle
Cormax 0.05% Solution 25ml Bottle45.99USD bottle
Cormax 0.05% Cream 15 gm Tube43.98USD tube
Diltiazem hcl 100 mg vial9.54USD vial
Diltiazem hcl powder8.42USD g
Cardizem CD 360 mg 24 Hour Capsule7.94USD capsule
Cardizem cd 360 mg capsule7.63USD capsule
Cardizem CD 300 mg 24 Hour Capsule7.3USD capsule
Cardizem LA 420 mg 24 Hour tablet5.56USD tablet
Cardizem CD 240 mg 24 Hour Capsule5.48USD capsule
Cardizem la 420 mg tablet5.35USD tablet
Diltiazem HCl Coated Beads 420 mg 24 Hour tablet5.01USD tablet
Cardizem la 360 mg tablet4.94USD tablet
Cardizem LA 360 mg 24 Hour tablet4.81USD tablet
Cardizem LA 300 mg 24 Hour tablet4.71USD tablet
Diltiazem HCl Coated Beads 360 mg 24 Hour tablet4.62USD tablet
Cardizem la 300 mg tablet4.59USD tablet
Diltiazem HCl Coated Beads 300 mg 24 Hour tablet4.3USD tablet
Cardizem CD 180 mg 24 Hour Capsule3.98USD capsule
Tiazac 420 mg 24 Hour Capsule3.88USD capsule
Tiazac 360 mg 24 Hour Capsule3.7USD capsule
Cardizem LA 240 mg 24 Hour tablet3.67USD tablet
Tiazac 300 mg 24 Hour Capsule3.64USD capsule
Cardizem la 240 mg tablet3.53USD tablet
Cardizem 120 mg tablet3.49USD tablet
Cardizem CD 120 mg 24 Hour Capsule3.4USD capsule
Dilacor XR 180 mg 24 Hour Capsule3.3USD capsule
Dilacor XR 240 mg 24 Hour Capsule3.3USD capsule
Diltiazem HCl Coated Beads 240 mg 24 Hour tablet3.3USD tablet
Dilacor xr 240 mg capsule3.29USD capsule
Cardizem Cd 300 mg Controlled-Delivery Capsule3.25USD capsule
Cardizem la 180 mg tablet3.15USD tablet
Cardizem LA 180 mg 24 Hour tablet3.07USD tablet
Dilacor xr 180 mg capsule3.07USD capsule
Tiazac er 420 mg capsule3.03USD capsule
Cardizem la 120 mg tablet2.98USD tablet
Diltiazem HCl Coated Beads 180 mg 24 Hour tablet2.95USD tablet
Diltiazem HCl ER Beads 420 mg 24 Hour Capsule2.87USD capsule
Dilacor XR 120 mg 24 Hour Capsule2.86USD capsule
Tiazac er 360 mg capsule2.86USD capsule
Tiazac er 300 mg capsule2.83USD capsule
Tiazac 240 mg 24 Hour Capsule2.8USD capsule
Cartia XT 300 mg 24 Hour Capsule2.76USD capsule
Dilt-CD 300 mg 24 Hour Capsule2.76USD capsule
Diltiazem HCl Coated Beads 300 mg 24 Hour Capsule2.76USD capsule
Cormax 0.05% cream2.71USD g
Cartia xt 300 mg capsule2.66USD capsule
Dilt-cd er 300 mg capsule2.66USD capsule
Dilacor xr 120 mg capsule2.61USD capsule
Cardizem Cd 240 mg Controlled-Delivery Capsule2.6USD capsule
Diltiazem HCl ER Beads 360 mg 24 Hour Capsule2.44USD capsule
Tiazac 360 mg Extended-Release Capsule2.42USD capsule
Diltiazem HCl ER Beads 300 mg 24 Hour Capsule2.39USD capsule
Cardizem LA 120 mg 24 Hour tablet2.35USD tablet
Tiazac 240 mg capsule sa2.31USD capsule
Tiazac er 240 mg capsule2.18USD capsule
Cardizem cd 300 mg capsule2.15USD capsule
Cartia XT 240 mg 24 Hour Capsule2.13USD capsule
Diltiazem HCl Coated Beads 240 mg 24 Hour Capsule2.13USD capsule
Dilt-cd 240 mg capsule2.05USD capsule
Cardizem 90 mg tablet2.02USD tablet
Tiazac 180 mg 24 Hour Capsule1.98USD capsule
Tiazac 300 mg Extended-Release Capsule1.98USD capsule
Cardizem Cd 180 mg Controlled-Delivery Capsule1.96USD capsule
Diltiazem HCl ER Beads 240 mg 24 Hour Capsule1.85USD capsule
Cardizem sr 120 mg capsule1.83USD capsule
Apo-Diltiaz Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Novo-Diltazem Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Ratio-Diltiazem Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Sandoz Diltiazem Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Cardizem cd 240 mg capsule1.69USD capsule
Tiazac 120 mg 24 Hour Capsule1.69USD capsule
Tiazac 240 mg Extended-Release Capsule1.61USD capsule
Tiazac er 180 mg capsule1.52USD capsule
Cartia XT 180 mg 24 Hour Capsule1.5USD capsule
Dilt-CD 180 mg 24 Hour Capsule1.5USD capsule
Diltiazem HCl Coated Beads 180 mg 24 Hour Capsule1.5USD capsule
Cardizem Cd 120 mg Controlled-Delivery Capsule1.48USD capsule
Apo-Diltiaz Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Novo-Diltazem Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Nu-Diltiaz-Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Ratio-Diltiazem Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Sandoz Diltiazem Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Tiazac Xc 240 mg Extended-Release Tablet1.46USD tablet
Tiazac Xc 300 mg Extended-Release Tablet1.46USD tablet
Tiazac Xc 360 mg Extended-Release Tablet1.46USD tablet
Dilt-cd 180 mg capsule1.45USD capsule
Diltiazem HCl 120 mg tablet1.42USD tablet
Diltiazem 120 mg tablet1.36USD tablet
Apo-Diltiaz Tz 360 mg Extended-Release Capsule1.36USD capsule
Novo-Diltiazem Hcl Er 360 mg Extended-Release Capsule1.36USD capsule
Sandoz Diltiazem T 360 mg Extended-Release Capsule1.36USD capsule
Cardizem 30 mg tablet1.34USD tablet
Diltiazem HCl ER Beads 180 mg 24 Hour Capsule1.3USD capsule
Diltiazem HCl CR 120 mg 12 Hour Capsule1.29USD capsule
Tiazac er 120 mg capsule1.26USD capsule
Cartia XT 120 mg 24 Hour Capsule1.25USD capsule
Dilt-CD 120 mg 24 Hour Capsule1.25USD capsule
Diltiazem HCl Coated Beads 120 mg 24 Hour Capsule1.25USD capsule
Cardizem cd 180 mg capsule1.24USD capsule
Tiazac 180 mg Extended-Release Capsule1.21USD capsule
Cartia xt 120 mg capsule1.2USD capsule
Dilt-cd 120 mg capsule1.2USD capsule
Diltiazem HCl CR 240 mg 24 Hour Capsule1.19USD capsule
Diltia XT 240 mg 24 Hour Capsule1.17USD capsule
Diltiazem HCl CR 180 mg 24 Hour Capsule1.11USD capsule
Apo-Diltiaz Tz 300 mg Extended-Release Capsule1.11USD capsule
Novo-Diltiazem Hcl Er 300 mg Extended-Release Capsule1.11USD capsule
Sandoz Diltiazem T 300 mg Extended-Release Capsule1.11USD capsule
Tiazac Xc 180 mg Extended-Release Tablet1.1USD tablet
Diltia XT 180 mg 24 Hour Capsule1.1USD capsule
Apo-Diltiaz Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Novo-Diltazem Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Nu-Diltiaz-Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Ratio-Diltiazem Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Sandoz Diltiazem Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Diltiazem HCl ER Beads 120 mg 24 Hour Capsule1.08USD capsule
Diltiazem HCl 90 mg tablet1.05USD tablet
Diltiazem 90 mg tablet1.01USD tablet
Diltiazem HCl CR 90 mg 12 Hour Capsule0.99USD capsule
Cardizem cd 120 mg capsule0.97USD capsule
Cardizem 60 mg tablet0.95USD tablet
Diltiazem HCl CR 120 mg 24 Hour Capsule0.95USD capsule
Apo-Diltiaz Tz 240 mg Extended-Release Capsule0.9USD capsule
Novo-Diltiazem Hcl Er 240 mg Extended-Release Capsule0.9USD capsule
Sandoz Diltiazem T 240 mg Extended-Release Capsule0.9USD capsule
Tiazac 120 mg Extended-Release Capsule0.89USD capsule
Diltiazem HCl CR 60 mg 12 Hour Capsule0.86USD capsule
Apo-Diltiaz Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Novo-Diltazem Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Nu-Diltiaz-Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Ratio-Diltiazem Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Sandoz Diltiazem Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Tiazac Xc 120 mg Extended-Release Tablet0.83USD tablet
Cartia xt 240 mg capsule0.81USD capsule
Diltiazem HCl 60 mg tablet0.77USD tablet
Diltiazem 60 mg tablet0.74USD tablet
Apo-Diltiaz Tz 180 mg Extended-Release Capsule0.68USD capsule
Novo-Diltiazem Hcl Er 180 mg Extended-Release Capsule0.68USD capsule
Sandoz Diltiazem T 180 mg Extended-Release Capsule0.68USD capsule
Cartia xt 180 mg capsule0.6USD capsule
Apo-Diltiaz Tz 120 mg Extended-Release Capsule0.5USD capsule
Novo-Diltiazem Hcl Er 120 mg Extended-Release Capsule0.5USD capsule
Sandoz Diltiazem T 120 mg Extended-Release Capsule0.5USD capsule
Diltiazem HCl 30 mg tablet0.49USD tablet
Diltiazem 30 mg tablet0.47USD tablet
Diltia xt 240 mg capsule0.43USD capsule
Diltia xt 180 mg capsule0.42USD capsule
Diltiazem-d5w 250 mg/250 ml0.42USD ml
Diltia xt 120 mg capsule0.38USD capsule
Apo-Diltiaz 60 mg Tablet0.38USD tablet
Novo-Diltazem 60 mg Tablet0.38USD tablet
Nu-Diltiaz 60 mg Tablet0.38USD tablet
Apo-Diltiaz 30 mg Tablet0.22USD tablet
Novo-Diltazem 30 mg Tablet0.22USD tablet
Nu-Diltiaz 30 mg Tablet0.22USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
Canada21110851999-04-272012-06-25
Canada23075472007-08-142020-05-04
United States52864971994-05-202011-05-20
United States69239842001-02-252021-02-25
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point187-188Kugita, H., Inoue, H., Ikezaki, M. and Takeo, S.; U.S. Patent 3,562,257; assigned to Tanabe Seiyaku Co.,Ltd., Japan.
water solubility465 mg/L (at 25 °C)MCFARLAND,JW ET AL. (2001)
logP2.8Not Available
Caco2 permeability-4.38ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.0168 mg/mLALOGPS
logP3.09ALOGPS
logP2.73ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)12.86ChemAxon
pKa (Strongest Basic)8.18ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area59.08 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity114.37 m3·mol-1ChemAxon
Polarizability43.65 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraMS
References
Synthesis Reference

Kugita, H., Inoue, H., Ikezaki, M. and Takeo, S.; U.S. Patent 3,562,257; assigned to Tanabe Seiyaku Co.,Ltd., Japan.

US3562257
General ReferenceNot Available
External Links
ATC CodesC05AE03C08DB01
AHFS Codes
  • 24:28.92
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.2 KB)
Interactions
Drug Interactions
Drug
Acetylsalicylic acidCalcium Channel Blockers (Nondihydropyridine) may enhance the anticoagulant effect of Salicylates.
AlfentanilDiltiazem may increase the serum concentration of Alfentanil.
AlfuzosinMay enhance the hypotensive effect of Antihypertensives.
AmifostineAntihypertensives may enhance the hypotensive effect of Amifostine.
AmiodaroneCalcium Channel Blockers (Nondihydropyridine) may enhance the bradycardic effect of Amiodarone. Sinus arrest has been reported.
AprepitantMay increase the serum concentration of Diltiazem. Diltiazem may increase the serum concentration of Aprepitant.
AripiprazoleCYP3A4 Inhibitors (Moderate) may increase the serum concentration of ARIPiprazole.
AtorvastatinMay increase the serum concentration of Diltiazem. Diltiazem may increase the serum concentration of AtorvaSTATin.
AvanafilCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Avanafil.
BatimastatMay decrease the metabolism of Calcium Channel Blockers (Nondihydropyridine). Increased serum concentrations of the calcium channel blocker may increase risk of AV nodal blockade.
BosentanMay decrease the serum concentration of CYP3A4 Substrates.
BosutinibCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Bosutinib.
BretyliumMay enhance the bradycardic effect of Bradycardia-Causing Agents. Bretylium may also enhance atrioventricular (AV) blockade in patients receiving AV blocking agents.
BuspironeCalcium Channel Blockers (Nondihydropyridine) may decrease the metabolism of BusPIRone.
ButabarbitalMay increase the metabolism of Calcium Channel Blockers.
ButethalMay increase the metabolism of Calcium Channel Blockers.
CarbamazepineMay decrease the serum concentration of Calcium Channel Blockers (Nondihydropyridine). Calcium Channel Blockers (Nondihydropyridine) may increase the serum concentration of CarBAMazepine.
CilostazolCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Cilostazol.
CimetidineMay increase the serum concentration of Calcium Channel Blockers.
ClonidineMay enhance the AV-blocking effect of Calcium Channel Blockers (Nondihydropyridine). Sinus node dysfunction may also be enhanced.
ClopidogrelCalcium Channel Blockers may diminish the therapeutic effect of Clopidogrel.
ColchicineCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Colchicine.
ColestipolMay decrease the absorption of Diltiazem.
ConivaptanMay increase the serum concentration of CYP3A4 Substrates.
DabrafenibMay decrease the serum concentration of CYP3A4 Substrates.
DantroleneMay enhance the hyperkalemic effect of Calcium Channel Blockers (Nondihydropyridine). Dantrolene may enhance the negative inotropic effect of Calcium Channel Blockers (Nondihydropyridine).
DapoxetineCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Dapoxetine.
DasatinibMay increase the serum concentration of CYP3A4 Substrates.
DeferasiroxMay decrease the serum concentration of CYP3A4 Substrates.
DiazoxideMay enhance the hypotensive effect of Antihypertensives.
DofetilideCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Dofetilide.
DomperidoneCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Domperidone.
DronabinolCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Dronabinol.
DronedaroneCalcium Channel Blockers (Nondihydropyridine) may enhance the AV-blocking effect of Dronedarone. Other electrophysiologic effects of Dronedarone may also be increased. Dronedarone may increase the serum concentration of Calcium Channel Blockers (Nondihydropyridine). Calcium Channel Blockers (Nondihydropyridine) may increase the serum concentration of Dronedarone.
DuloxetineHypotensive Agents may enhance the orthostatic hypotensive effect of DULoxetine.
EfavirenzMay decrease the serum concentration of Diltiazem.
EletriptanCalcium Channel Blockers (Nondihydropyridine) may decrease the metabolism of Eletriptan.
EliglustatCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Eliglustat.
EplerenoneCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Eplerenone.
EverolimusCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Everolimus.
FentanylCYP3A4 Inhibitors (Moderate) may increase the serum concentration of FentaNYL.
FingolimodDiltiazem may enhance the bradycardic effect of Fingolimod.
FluconazoleMay increase the serum concentration of Calcium Channel Blockers.
FosaprepitantDiltiazem may increase the serum concentration of Fosaprepitant. Specifically, diltiazem may increase the concentration of the active metabolite aprepitant. Fosaprepitant may increase the serum concentration of Diltiazem. The active metabolite aprepitant is likely responsible for this effect.
FosphenytoinCalcium Channel Blockers may increase the serum concentration of Fosphenytoin.
HalofantrineCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Halofantrine.
HeptabarbitalMay increase the metabolism of Calcium Channel Blockers.
HexobarbitalMay increase the metabolism of Calcium Channel Blockers.
HydrocodoneCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Hydrocodone.
IfosfamideCYP3A4 Inhibitors (Moderate) may decrease serum concentrations of the active metabolite(s) of Ifosfamide.
ImatinibCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Imatinib.
IsoflurophateMay decrease the metabolism of Calcium Channel Blockers (Nondihydropyridine). Increased serum concentrations of the calcium channel blocker may increase risk of AV nodal blockade.
IvacaftorCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Ivacaftor.
LacosamideBradycardia-Causing Agents may enhance the AV-blocking effect of Lacosamide.
LithiumCalcium Channel Blockers (Nondihydropyridine) may enhance the neurotoxic effect of Lithium. Calcium Channel Blockers (Nondihydropyridine) may increase the serum concentration of Lithium. Decreased or unaltered lithium concentrations have also been reported with this combination.
LomitapideCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Lomitapide.
LovastatinMay increase the serum concentration of Lovastatin. Lovastatin may increase the serum concentration of Diltiazem.
LULICONAZOLEMay increase the serum concentration of CYP3A4 Substrates.
LurasidoneCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Lurasidone.
MethohexitalMay increase the metabolism of Calcium Channel Blockers.
MethylphenidateMay diminish the antihypertensive effect of Antihypertensives.
MidodrineCalcium Channel Blockers (Nondihydropyridine) may enhance the bradycardic effect of Midodrine.
MifepristoneMay increase the serum concentration of CYP3A4 Substrates.
MitotaneMay decrease the serum concentration of CYP3A4 Substrates.
NafcillinMay increase the metabolism of Calcium Channel Blockers.
NitroprussideCalcium Channel Blockers may enhance the hypotensive effect of Nitroprusside.
ObinutuzumabAntihypertensives may enhance the hypotensive effect of Obinutuzumab.
OxycodoneCYP3A4 Inhibitors (Moderate) may enhance the adverse/toxic effect of OxyCODONE. CYP3A4 Inhibitors (Moderate) may increase the serum concentration of OxyCODONE. Serum concentrations of the active metabolite Oxymorphone may also be increased.
PentobarbitalMay increase the metabolism of Calcium Channel Blockers.
PentoxifyllineMay enhance the hypotensive effect of Antihypertensives.
PhenytoinCalcium Channel Blockers may increase the serum concentration of Phenytoin.
PimecrolimusCYP3A4 Inhibitors (Moderate) may decrease the metabolism of Pimecrolimus.
PimozideCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Pimozide.
PrimidoneMay increase the metabolism of Calcium Channel Blockers.
PropafenoneCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Propafenone.
QuinidineDiltiazem may increase the serum concentration of QuiNIDine.
RanolazineCalcium Channel Blockers (Nondihydropyridine) may increase the serum concentration of Ranolazine.
RegorafenibMay enhance the bradycardic effect of Calcium Channel Blockers (Nondihydropyridine).
RifampicinRifampin may decrease the serum concentration of Diltiazem.
RisperidoneHypotensive Agents may enhance the hypotensive effect of RisperiDONE.
RituximabAntihypertensives may enhance the hypotensive effect of RiTUXimab.
RivaroxabanCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Rivaroxaban. This warning is more specifically for drugs that are inhibitors of both CYP3A4 and P-glycoprotein. For erythromycin, refer to more specific erythromycin-rivaroxaban monograph recommendations.
RuxolitinibMay enhance the bradycardic effect of Bradycardia-Causing Agents.
Salicylate-sodiumCalcium Channel Blockers (Nondihydropyridine) may enhance the anticoagulant effect of Salicylates.
SalmeterolCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Salmeterol.
SaxagliptinCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Saxagliptin.
SecobarbitalMay increase the metabolism of Calcium Channel Blockers.
SiltuximabMay decrease the serum concentration of CYP3A4 Substrates.
SimeprevirMay decrease the metabolism of Calcium Channel Blockers (Nondihydropyridine). Increased serum concentrations of the calcium channel blocker may increase risk of AV nodal blockade.
SimvastatinDiltiazem may increase the serum concentration of Simvastatin. Simvastatin may increase the serum concentration of Diltiazem.
SuvorexantCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Suvorexant.
TadalafilMay enhance the antihypertensive effect of Antihypertensives.
TocilizumabMay decrease the serum concentration of CYP3A4 Substrates.
TofacitinibMay enhance the bradycardic effect of Bradycardia-Causing Agents.
TolvaptanCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Tolvaptan.
TrabectedinCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Trabectedin.
UlipristalCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Ulipristal.
VardenafilMay enhance the antihypertensive effect of Antihypertensives.
VilazodoneCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Vilazodone.
YohimbineMay diminish the antihypertensive effect of Antihypertensives.
ZopicloneCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Zopiclone.
ZuclopenthixolCYP3A4 Inhibitors (Moderate) may increase the serum concentration of Zuclopenthixol.
Food Interactions
  • Avoid natural licorice.
  • Take this medication 30 minutes before meals.

Targets

1. Voltage-dependent calcium channel gamma-1 subunit

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Voltage-dependent calcium channel gamma-1 subunit Q06432 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Budriesi R, Ioan P, Carosati E, Cruciani G, Zhorov BS, Chiarini A: Ligands of diltiazem binding site: an overview of some chemotypes. Mini Rev Med Chem. 2009 Oct;9(12):1379-88. Pubmed
  4. Romero M, Sanchez I, Pujol MD: New advances in the field of calcium channel antagonists: cardiovascular effects and structure-activity relationships. Curr Med Chem Cardiovasc Hematol Agents. 2003 Jun;1(2):113-41. Pubmed

Enzymes

1. Cytochrome P450 3A4

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  3. Williams JA, Ring BJ, Cantrell VE, Jones DR, Eckstein J, Ruterbories K, Hamman MA, Hall SD, Wrighton SA: Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab Dispos. 2002 Aug;30(8):883-91. Pubmed

2. Cytochrome P450 3A5

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 3A5 P20815 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 3A7

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 3A7 P24462 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.

4. Cytochrome P450 2C19

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C19 P33261 Details

References:

  1. Kosuge K, Jun Y, Watanabe H, Kimura M, Nishimoto M, Ishizaki T, Ohashi K: Effects of CYP3A4 inhibition by diltiazem on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status. Drug Metab Dispos. 2001 Oct;29(10):1284-9. Pubmed
  2. McGinnity DF, Parker AJ, Soars M, Riley RJ: Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s. Drug Metab Dispos. 2000 Nov;28(11):1327-34. Pubmed

5. Cytochrome P450 2D6

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

6. Cytochrome P450 2C8

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C8 P10632 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

7. Cytochrome P450 2C9

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C9 P11712 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

Transporters

1. Multidrug resistance protein 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. Pubmed
  2. Takara K, Sakaeda T, Tanigawara Y, Nishiguchi K, Ohmoto N, Horinouchi M, Komada F, Ohnishi N, Yokoyama T, Okumura K: Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression. Eur J Pharm Sci. 2002 Aug;16(3):159-65. Pubmed
  3. Saeki T, Ueda K, Tanigawara Y, Hori R, Komano T: P-glycoprotein-mediated transcellular transport of MDR-reversing agents. FEBS Lett. 1993 Jun 7;324(1):99-102. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on April 14, 2014 14:12