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Identification
NameDiltiazem
Accession NumberDB00343  (APRD00473)
TypeSmall Molecule
GroupsApproved
DescriptionA benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. It is also teratogenic. [PubChem]
Structure
Thumb
Synonyms
(+)-cis-5-[2-(dimethylamino)Ethyl]-2,3-dihydro-3-hydroxy-2-(P-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester
(2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
(2S,3S)-5-(2-(dimethylamino)Ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
Diltiazem
Diltiazemum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Diltiazem CDcapsule (extended release)240 mgoralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem CDcapsule (extended release)300 mgoralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem CDcapsule (extended release)120 mgoralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem CDcapsule (extended release)180 mgoralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem Tcapsule (extended release)300 mgoralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem Tcapsule (extended release)120 mgoralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem Tcapsule (extended release)360 mgoralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem Tcapsule (extended release)180 mgoralActavis Pharma Company2011-10-06Not applicableCanada
Act Diltiazem Tcapsule (extended release)240 mgoralActavis Pharma Company2011-10-06Not applicableCanada
Alti-diltiazem Tab 30mgtablet30 mgoralAltimed Pharma Inc.1990-12-312005-05-27Canada
Alti-diltiazem Tab 60mgtablet60 mgoralAltimed Pharma Inc.1990-12-312005-05-27Canada
Ava-diltiazemtablet30 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-diltiazemtablet60 mgoralAvanstra Inc2011-10-112014-08-21Canada
Cardizemtablet, coated60 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs
Cardizemtablet30 mgoralBiovail Pharmaceuticals Canada Division Of Biovail Corporation1995-12-312007-03-27Canada
Cardizemcapsule180 mg/1oralCardinal Health2001-04-11Not applicableUs
Cardizemtablet, coated120 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs
Cardizemcapsule240 mg/1oralCardinal Health2001-04-11Not applicableUs
Cardizemtablet, coated30 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs
Cardizemtablet60 mgoralBiovail Pharmaceuticals Canada Division Of Biovail Corporation1995-12-312008-07-31Canada
Cardizem CDcapsule (extended release)120 mgoralValeant Canada Lp Valeant Canada S.E.C.1995-12-31Not applicableCanada
Cardizem CDcapsule, coated, extended release240 mg/1oralValeant Pharmaceuticals North America LLC2001-04-11Not applicableUs
Cardizem CDcapsule240 mg/1oralPhysicians Total Care, Inc.1993-06-16Not applicableUs
Cardizem CDcapsule (extended release)240 mgoralValeant Canada Lp Valeant Canada S.E.C.1995-12-31Not applicableCanada
Cardizem CDcapsule, coated, extended release300 mg/1oralValeant Pharmaceuticals North America LLC2001-04-11Not applicableUs
Cardizem CDcapsule, coated, extended release120 mg/1oralValeant Pharmaceuticals North America LLC2001-04-11Not applicableUs
Cardizem CDcapsule (extended release)180 mgoralValeant Canada Lp Valeant Canada S.E.C.1995-12-31Not applicableCanada
Cardizem CDcapsule, coated, extended release360 mg/1oralValeant Pharmaceuticals North America LLC2001-04-11Not applicableUs
Cardizem CDcapsule180 mg/1oralCardinal Health2001-04-112016-04-05Us
Cardizem CDcapsule, coated, extended release180 mg/1oralValeant Pharmaceuticals North America LLC2001-04-11Not applicableUs
Cardizem CDcapsule (extended release)300 mgoralValeant Canada Lp Valeant Canada S.E.C.1995-12-31Not applicableCanada
Cardizem Injectableliquid5 mgintravenousCrystaal, Division Of Biovail Corporation1995-12-312002-11-15Canada
Cardizem Injectable Liq 5mg/mlliquid5 mgintravenousLabs Nordic Laboratories Inc. Subsidary Of M.M.D.C.1993-12-311996-09-09Canada
Cardizem LAtablet, extended release120 mg/1oralAbb Vie Inc.2010-12-25Not applicableUs
Cardizem LAtablet, extended release180 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs
Cardizem LAtablet, extended release420 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs
Cardizem LAtablet, extended release360 mg/1oralAbb Vie Inc.2010-12-25Not applicableUs
Cardizem LAtablet, extended release180 mg/1oralAbb Vie Inc.2010-12-25Not applicableUs
Cardizem LAtablet, extended release240 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs
Cardizem LAtablet, extended release420 mg/1oralAbb Vie Inc.2010-12-25Not applicableUs
Cardizem LAtablet, extended release240 mg/1oralAbb Vie Inc.2010-12-25Not applicableUs
Cardizem LAtablet, extended release300 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs
Cardizem LAtablet, extended release360 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs
Cardizem LAtablet, extended release300 mg/1oralAbb Vie Inc.2010-12-25Not applicableUs
Cardizem LAtablet, extended release120 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs
Cardizem SR 120mgcapsule (sustained-release)120 mgoralBiovail Pharmaceuticals Canada Division Of Biovail Corporation1994-12-312004-11-11Canada
Cardizem SR 60mgcapsule (sustained-release)60 mgoralBiovail Pharmaceuticals Canada Division Of Biovail Corporation1995-12-312004-11-11Canada
Cardizem SR 90mgcapsule (sustained-release)90 mgoralBiovail Pharmaceuticals Canada Division Of Biovail Corporation1995-12-312004-11-11Canada
Dilacor XRcapsule, extended release120 mg/1oralActavis Pharma, Inc.1992-05-29Not applicableUs
Dilacor XRcapsule, extended release180 mg/1oralActavis Pharma, Inc.1992-05-29Not applicableUs
Dilacor XRcapsule, extended release240 mg/1oralActavis Pharma, Inc.1992-05-29Not applicableUs
Diltiazem - CDcapsule (controlled-delivery)240 mgoralPro Doc Limitee1998-06-02Not applicableCanada
Diltiazem - CDcapsule (controlled-delivery)300 mgoralPro Doc Limitee1998-10-09Not applicableCanada
Diltiazem - CDcapsule (controlled-delivery)120 mgoralPro Doc Limitee1998-06-01Not applicableCanada
Diltiazem - CDcapsule (controlled-delivery)180 mgoralPro Doc Limitee1998-06-02Not applicableCanada
Diltiazem CDcapsule (extended release)240 mgoralSivem Pharmaceuticals Ulc2015-10-06Not applicableCanada
Diltiazem CDcapsule (controlled-delivery)240 mgoralSanis Health Inc2013-02-13Not applicableCanada
Diltiazem CDcapsule (extended release)300 mgoralSivem Pharmaceuticals Ulc2015-10-06Not applicableCanada
Diltiazem CDcapsule (extended release)120 mgoralSivem Pharmaceuticals Ulc2015-10-06Not applicableCanada
Diltiazem CDcapsule (controlled-delivery)300 mgoralSanis Health Inc2013-02-13Not applicableCanada
Diltiazem CDcapsule (controlled-delivery)120 mgoralSanis Health Inc2013-02-13Not applicableCanada
Diltiazem CDcapsule (extended release)180 mgoralSivem Pharmaceuticals Ulc2015-10-06Not applicableCanada
Diltiazem CDcapsule (controlled-delivery)180 mgoralSanis Health Inc2013-02-13Not applicableCanada
Diltiazem HCl CDcapsule, coated, extended release360 mg/1oralOceanside Pharmaceuticals2012-07-18Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralCarilion Materials Management2009-09-25Not applicableUs
Diltiazem Hydrochloridetablet, extended release420 mg/1oralOceanside Pharmaceuticals2014-02-06Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralPhysicians Total Care, Inc.2000-05-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-09-25Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-09-25Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralbryant ranch prepack2009-09-25Not applicableUs
Diltiazem Hydrochloridetablet, extended release240 mg/1oralOceanside Pharmaceuticals2014-02-06Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralCarilion Materials Management2009-09-25Not applicableUs
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralPhysicians Total Care, Inc.2004-02-05Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-09-25Not applicableUs
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralbryant ranch prepack2009-09-25Not applicableUs
Diltiazem Hydrochloridetablet, extended release300 mg/1oralOceanside Pharmaceuticals2014-02-06Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralPhysicians Total Care, Inc.2000-11-14Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralCarilion Materials Management2009-09-25Not applicableUs
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralPhysicians Total Care, Inc.2005-01-17Not applicableUs
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-09-25Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralCarilion Materials Management2009-09-25Not applicableUs
Diltiazem Hydrochloridetablet, extended release360 mg/1oralOceanside Pharmaceuticals2014-02-06Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralPhysicians Total Care, Inc.2000-05-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralCarilion Materials Management2009-09-25Not applicableUs
Diltiazem Hydrochloridetablet, extended release180 mg/1oralOceanside Pharmaceuticals2014-02-06Not applicableUs
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-09-25Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, extended release360 mg/1oralOceanside Pharmaceuticals2014-08-20Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, extended release120 mg/1oralOceanside Pharmaceuticals2014-08-20Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, extended release420 mg/1oralOceanside Pharmaceuticals2014-08-20Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, extended release180 mg/1oralOceanside Pharmaceuticals2014-08-20Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, extended release240 mg/1oralOceanside Pharmaceuticals2014-08-20Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, extended release300 mg/1oralOceanside Pharmaceuticals2014-08-20Not applicableUs
Diltiazem Hydrochloride Injectionsolution5 mgintravenousMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Diltiazem Hydrochloride Injectionsolution5 mgintravenousSandoz Canada Incorporated2002-01-09Not applicableCanada
Diltiazem Hydrochloride Injectionsolution5 mgintravenousTeva Canada Limited1997-04-10Not applicableCanada
Diltiazem Tablets 30mgtablet30 mgoralPrempharm Inc1996-12-302005-08-05Canada
Diltiazem Tablets 60mgtablet60 mgoralPrempharm Inc1997-04-302005-08-05Canada
Diltiazem TZcapsule (extended release)180 mgoralPro Doc Limitee2009-06-15Not applicableCanada
Diltiazem TZcapsule (extended release)240 mgoralPro Doc Limitee2009-06-15Not applicableCanada
Diltiazem TZcapsule (extended release)300 mgoralPro Doc Limitee2009-06-15Not applicableCanada
Diltiazem TZcapsule (extended release)360 mgoralPro Doc Limitee2009-06-15Not applicableCanada
Diltiazem TZcapsule (extended release)120 mgoralPro Doc Limitee2009-06-15Not applicableCanada
Diltiazem-30 Tab 30mgtablet30 mgoralPro Doc Limitee1989-12-312012-07-23Canada
Diltiazem-60 Tab 60mgtablet60 mgoralPro Doc Limitee1989-12-312012-07-23Canada
Gen-diltiazem - Tab 30mgtablet30 mgoralGenpharm Ulc1995-12-312009-08-05Canada
Gen-diltiazem - Tab 60mgtablet60 mgoralGenpharm Ulc1995-12-312009-08-05Canada
Gen-diltiazem CDcapsule (extended release)300 mgoralGenpharm Ulc2004-08-172009-08-05Canada
Gen-diltiazem CDcapsule (extended release)120 mgoralGenpharm Ulc2004-08-172009-08-05Canada
Gen-diltiazem CDcapsule (extended release)180 mgoralGenpharm Ulc2004-08-172009-08-05Canada
Gen-diltiazem CDcapsule (extended release)240 mgoralGenpharm Ulc2004-08-172009-08-05Canada
Gen-diltiazem SR 120mgcapsule (sustained-release)120 mgoralGenpharm Ulc1997-07-182009-08-05Canada
Gen-diltiazem SR 60mgcapsule (sustained-release)60 mgoralGenpharm Ulc1997-07-182009-08-05Canada
Gen-diltiazem SR 90mgcapsule (sustained-release)90 mgoralGenpharm Ulc1997-07-182009-08-05Canada
Med Diltiazem - Tab 30mgtablet30 mgoralMedican Pharma Incorporated1997-01-232011-03-29Canada
Med Diltiazem - Tab 60mgtablet60 mgoralMedican Pharma Incorporated1997-03-122011-03-29Canada
Novo-diltazem SR Capsulescapsule (sustained-release)60 mgoralNovopharm Limited1997-03-192005-08-10Canada
Novo-diltazem SR Capsulescapsule (sustained-release)90 mgoralNovopharm Limited1997-03-192005-08-10Canada
Novo-diltazem SR Capsulescapsule (sustained-release)120 mgoralNovopharm Limited1997-03-192005-08-10Canada
Nu-diltiaz Tab 30mgtablet30 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Nu-diltiaz Tab 60mgtablet60 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Nu-diltiaz-CD Capsulescapsule (controlled-delivery)300 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-diltiaz-CD Capsules 120mgcapsule (controlled-delivery)120 mgoralNu Pharm Inc1998-08-052012-09-04Canada
Nu-diltiaz-CD Capsules 180mgcapsule (controlled-delivery)180 mgoralNu Pharm Inc1998-08-052012-09-04Canada
Nu-diltiaz-CD Capsules 240mgcapsule (controlled-delivery)240 mgoralNu Pharm Inc1998-08-052012-09-04Canada
Penta-diltiazem - 30mgtablet30 mgoralPentapharm Ltd.Not applicableNot applicableCanada
Penta-diltiazem - 60mgtablet60 mgoralPentapharm Ltd.Not applicableNot applicableCanada
PMS-diltiazem CDcapsule (controlled-delivery)300 mgoralPharmascience Inc2010-10-19Not applicableCanada
PMS-diltiazem CDcapsule (controlled-delivery)120 mgoralPharmascience Inc2010-10-19Not applicableCanada
PMS-diltiazem CDcapsule (controlled-delivery)180 mgoralPharmascience Inc2010-10-19Not applicableCanada
PMS-diltiazem CDcapsule (controlled-delivery)240 mgoralPharmascience Inc2010-10-19Not applicableCanada
Ratio-diltiazem CDcapsule (controlled-delivery)120 mgoralRatiopharm Inc Division Of Teva Canada Limited1997-01-022014-09-19Canada
Ratio-diltiazem CDcapsule (controlled-delivery)180 mgoralRatiopharm Inc Division Of Teva Canada Limited1997-01-022014-09-19Canada
Ratio-diltiazem CDcapsule (controlled-delivery)240 mgoralRatiopharm Inc Division Of Teva Canada Limited1997-01-022014-09-19Canada
Ratio-diltiazem CDcapsule (controlled-delivery)300 mgoralRatiopharm Inc Division Of Teva Canada Limited1997-01-022014-09-19Canada
Sandoz Diltiazem CDcapsule (extended release)240 mgoralSandoz Canada Incorporated2001-02-20Not applicableCanada
Sandoz Diltiazem CDcapsule (extended release)300 mgoralSandoz Canada Incorporated2001-02-20Not applicableCanada
Sandoz Diltiazem CDcapsule (extended release)120 mgoralSandoz Canada Incorporated2001-02-20Not applicableCanada
Sandoz Diltiazem CDcapsule (extended release)180 mgoralSandoz Canada Incorporated2001-02-20Not applicableCanada
Sandoz Diltiazem Tcapsule (extended release)180 mgoralSandoz Canada Incorporated2006-01-26Not applicableCanada
Sandoz Diltiazem Tcapsule (extended release)240 mgoralSandoz Canada Incorporated2006-01-26Not applicableCanada
Sandoz Diltiazem Tcapsule (extended release)300 mgoralSandoz Canada Incorporated2006-01-26Not applicableCanada
Sandoz Diltiazem Tcapsule (extended release)360 mgoralSandoz Canada Incorporated2006-01-26Not applicableCanada
Sandoz Diltiazem Tcapsule (extended release)120 mgoralSandoz Canada Incorporated2006-01-26Not applicableCanada
Taro-diltiazem Tcapsule (extended release)360 mgoralTaro Pharmaceuticals IncNot applicableNot applicableCanada
Taro-diltiazem Tcapsule (extended release)120 mgoralTaro Pharmaceuticals IncNot applicableNot applicableCanada
Taro-diltiazem Tcapsule (extended release)180 mgoralTaro Pharmaceuticals IncNot applicableNot applicableCanada
Taro-diltiazem Tcapsule (extended release)240 mgoralTaro Pharmaceuticals IncNot applicableNot applicableCanada
Taro-diltiazem Tcapsule (extended release)300 mgoralTaro Pharmaceuticals IncNot applicableNot applicableCanada
Taro-diltiazem Tab 30mgtablet30 mgoralTaro Pharmaceuticals Inc1996-12-312000-08-31Canada
Taro-diltiazem Tab 60mgtablet60 mgoralTaro Pharmaceuticals Inc1996-12-312000-08-31Canada
Teva-diltiazemtablet30 mgoralTeva Canada Limited1990-12-31Not applicableCanada
Teva-diltiazemtablet60 mgoralTeva Canada Limited1990-12-31Not applicableCanada
Teva-diltiazem CDcapsule (extended release)240 mgoralTeva Canada Limited2000-10-06Not applicableCanada
Teva-diltiazem CDcapsule (extended release)300 mgoralTeva Canada Limited2000-10-06Not applicableCanada
Teva-diltiazem CDcapsule (extended release)120 mgoralTeva Canada Limited2000-10-06Not applicableCanada
Teva-diltiazem CDcapsule (extended release)180 mgoralTeva Canada Limited2000-10-06Not applicableCanada
Teva-diltiazem HCl ER Capsulescapsule (extended release)240 mgoralValeant Canada Lp Valeant Canada S.E.C.2006-01-30Not applicableCanada
Teva-diltiazem HCl ER Capsulescapsule (extended release)300 mgoralValeant Canada Lp Valeant Canada S.E.C.2006-01-30Not applicableCanada
Teva-diltiazem HCl ER Capsulescapsule (extended release)120 mgoralValeant Canada Lp Valeant Canada S.E.C.2006-01-30Not applicableCanada
Teva-diltiazem HCl ER Capsulescapsule (extended release)360 mgoralValeant Canada Lp Valeant Canada S.E.C.2006-01-30Not applicableCanada
Teva-diltiazem HCl ER Capsulescapsule (extended release)180 mgoralValeant Canada Lp Valeant Canada S.E.C.2006-01-30Not applicableCanada
Tiazaccapsule (extended release)120 mgoralValeant Canada Lp Valeant Canada S.E.C.1997-06-09Not applicableCanada
Tiazaccapsule (extended release)360 mgoralValeant Canada Lp Valeant Canada S.E.C.1997-06-09Not applicableCanada
Tiazaccapsule (extended release)180 mgoralValeant Canada Lp Valeant Canada S.E.C.1997-06-09Not applicableCanada
Tiazaccapsule (extended release)240 mgoralValeant Canada Lp Valeant Canada S.E.C.1997-06-09Not applicableCanada
Tiazaccapsule (extended release)300 mgoralValeant Canada Lp Valeant Canada S.E.C.1997-06-09Not applicableCanada
Tiazac Extended Releasecapsule, extended release240 mg/1oralValeant Pharmaceuticals North America LLC2014-08-20Not applicableUs
Tiazac Extended Releasecapsule, extended release240 mg/1oralCardinal Health2009-09-24Not applicableUs
Tiazac Extended Releasecapsule, extended release300 mg/1oralValeant Pharmaceuticals North America LLC2014-08-20Not applicableUs
Tiazac Extended Releasecapsule, extended release300 mg/1oralCardinal Health2009-09-24Not applicableUs
Tiazac Extended Releasecapsule, extended release120 mg/1oralValeant Pharmaceuticals North America LLC2014-08-20Not applicableUs
Tiazac Extended Releasecapsule, extended release360 mg/1oralValeant Pharmaceuticals North America LLC2014-08-20Not applicableUs
Tiazac Extended Releasecapsule, extended release360 mg/1oralCardinal Health2009-09-24Not applicableUs
Tiazac Extended Releasecapsule, extended release120 mg/1oralCardinal Health2009-09-24Not applicableUs
Tiazac Extended Releasecapsule, extended release180 mg/1oralValeant Pharmaceuticals North America LLC2014-08-20Not applicableUs
Tiazac Extended Releasecapsule, extended release420 mg/1oralValeant Pharmaceuticals North America LLC2014-08-20Not applicableUs
Tiazac Extended Releasecapsule, extended release420 mg/1oralCardinal Health2009-09-24Not applicableUs
Tiazac Extended Releasecapsule, extended release180 mg/1oralCardinal Health2009-09-24Not applicableUs
Tiazac Xctablet (extended-release)300 mgoralValeant Canada Lp Valeant Canada S.E.C.2004-08-13Not applicableCanada
Tiazac Xctablet (extended-release)120 mgoralValeant Canada Lp Valeant Canada S.E.C.2004-08-13Not applicableCanada
Tiazac Xctablet (extended-release)360 mgoralValeant Canada Lp Valeant Canada S.E.C.2004-08-13Not applicableCanada
Tiazac Xctablet (extended-release)180 mgoralValeant Canada Lp Valeant Canada S.E.C.2004-08-13Not applicableCanada
Tiazac Xctablet (extended-release)240 mgoralValeant Canada Lp Valeant Canada S.E.C.2004-08-13Not applicableCanada
Tria-diltiazem 30mg Tabletstablet30 mgoralLaboratoires Trianon IncNot applicableNot applicableCanada
Tria-diltiazem 60 Mg Tabletstablet60 mgoralLaboratoires Trianon IncNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Diltiaz Tab 30mgtablet30 mgoralApotex Inc1988-12-31Not applicableCanada
Apo Diltiaz Tab 60mgtablet60 mgoralApotex Inc1988-12-31Not applicableCanada
Apo-diltiaz CDcapsule (controlled-delivery)180 mgoralApotex Inc1997-03-27Not applicableCanada
Apo-diltiaz CDcapsule (controlled-delivery)240 mgoralApotex Inc1997-03-27Not applicableCanada
Apo-diltiaz CDcapsule (controlled-delivery)120 mgoralApotex Inc1997-03-27Not applicableCanada
Apo-diltiaz CD - Cap 300mgcapsule (controlled-delivery)300 mgoralApotex Inc1996-09-12Not applicableCanada
Apo-diltiaz Injectableliquid5 mgintravenousApotex Inc2000-06-202013-08-02Canada
Apo-diltiaz SR - 90mg/srccapsule (sustained-release)90 mgoralApotex Inc1996-09-19Not applicableCanada
Apo-diltiaz SR - Src 120mgcapsule (sustained-release)120 mgoralApotex Inc1996-09-19Not applicableCanada
Apo-diltiaz SR - Src 60mgcapsule (sustained-release)60 mgoralApotex Inc1996-09-19Not applicableCanada
Apo-diltiaz TZcapsule (extended release)180 mgoralApotex Inc2008-07-25Not applicableCanada
Apo-diltiaz TZcapsule (extended release)240 mgoralApotex Inc2008-07-25Not applicableCanada
Apo-diltiaz TZcapsule (extended release)300 mgoralApotex Inc2008-07-25Not applicableCanada
Apo-diltiaz TZcapsule (extended release)120 mgoralApotex Inc2008-07-25Not applicableCanada
Apo-diltiaz TZcapsule (extended release)360 mgoralApotex Inc2008-07-25Not applicableCanada
Cartia Xtcapsule, extended release240 mg/1oralActavis Pharma, Inc.1999-06-23Not applicableUs
Cartia Xtcapsule, extended release300 mg/1oralActavis Pharma, Inc.1999-06-23Not applicableUs
Cartia Xtcapsule, extended release120 mg/1oralActavis Pharma, Inc.1999-06-23Not applicableUs
Cartia Xtcapsule, extended release180 mg/1oralActavis Pharma, Inc.1999-06-23Not applicableUs
Dilacor XRcapsule, extended release240 mg/1oralWatson Pharma, Inc.1998-03-18Not applicableUs
Dilt-CDcapsule240 mg/1oralApotex Corp.2006-08-30Not applicableUs
Dilt-CDcapsule300 mg/1oralApotex Corp.2006-08-30Not applicableUs
Dilt-CDcapsule120 mg/1oralApotex Corp.2006-08-30Not applicableUs
Dilt-CDcapsule180 mg/1oralApotex Corp.2006-08-30Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralPhysicians Total Care, Inc.2004-05-24Not applicableUs
Diltiazem Hydrochloridetablet, extended release180 mg/1oralWatson Pharma, Inc.2010-03-15Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralbryant ranch prepack1995-12-22Not applicableUs
Diltiazem Hydrochloridecapsule, extended release420 mg/1oralSandoz Inc2012-10-01Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralOceanside Pharmaceuticals1999-12-28Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralLake Erie Medical DBA Quality Care Products LLC1995-12-22Not applicableUs
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralSun Pharma Global FZE2011-10-31Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralUnit Dose Services1999-12-20Not applicableUs
Diltiazem Hydrochloridetablet, film coated90 mg/1oralMylan Pharmaceuticals Inc.1992-03-16Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-12-04Not applicableUs
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralTEVA Pharmaceuticals USA Inc.1999-12-28Not applicableUs
Diltiazem Hydrochloridetablet, film coated30 mg/1oralTeva Pharmaceuticals USA Inc1995-12-22Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralMylan Institutional Inc.2000-10-01Not applicableUs
Diltiazem Hydrochloridecapsule, extended release90 mg/1oralREMEDYREPACK INC.2015-07-16Not applicableUs
Diltiazem Hydrochlorideinjection5 mg/mLintravenousWest Ward Pharmaceutical Corp.2008-12-17Not applicableUs
Diltiazem Hydrochloridetablet, film coated120 mg/1oralRebel Distributors Corp1992-11-05Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralSun Pharma Global FZE2010-11-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralREMEDYREPACK INC.2011-09-08Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralActavis Elizabeth LLC1999-12-20Not applicableUs
Diltiazem Hydrochlorideinjection, solution5 mg/mLintravenousHospira, Inc.2012-04-10Not applicableUs
Diltiazem Hydrochloridetablet, film coated30 mg/1oralMc Kesson Contract Packaging2011-11-04Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralAv Kare, Inc.2014-01-09Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralREMEDYREPACK INC.2011-03-23Not applicableUs
Diltiazem Hydrochloridecapsule, extended release60 mg/1oralMylan Institutional Inc.1999-12-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralMylan Pharmaceuticals Inc.1998-03-24Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralActavis Elizabeth LLC2012-10-01Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralCardinal Health2010-01-15Not applicableUs
Diltiazem Hydrochloridetablet, film coated30 mg/1oralPd Rx Pharmaceuticals, Inc.2011-11-10Not applicableUs
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralAmerican Health Packaging2015-03-31Not applicableUs
Diltiazem Hydrochloridetablet, extended release420 mg/1oralWatson Pharma, Inc.2010-03-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-07-24Not applicableUs
Diltiazem Hydrochlorideinjection5 mg/mLintravenousAkorn, Inc.2006-12-21Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralAmerican Health Packaging2010-01-152016-03-01Us
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralSandoz Inc2012-10-01Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralDispensing Solutions, Inc.1999-12-20Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralAidarex Pharmaceuticals LLC1999-12-28Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralSun Pharma Global FZE2011-10-31Not applicableUs
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralActavis Elizabeth LLC2013-11-25Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralTEVA Pharmaceuticals USA Inc.1999-12-28Not applicableUs
Diltiazem Hydrochloridetablet, film coated90 mg/1oralPhysicians Total Care, Inc.1996-05-16Not applicableUs
Diltiazem Hydrochloridetablet, film coated90 mg/1oralCardinal Health1992-11-05Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralApotex Corp.2001-07-30Not applicableUs
Diltiazem Hydrochloridetablet, film coated120 mg/1oralKAISER FOUNDATION HOSPITALS2012-02-13Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralPhysicians Total Care, Inc.2009-12-18Not applicableUs
Diltiazem Hydrochloridetablet, extended release240 mg/1oralWatson Pharma, Inc.2010-03-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralbryant ranch prepack2010-11-02Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralMajor Pharmaceuticals2010-05-12Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralOceanside Pharmaceuticals1999-12-28Not applicableUs
Diltiazem Hydrochloridetablet, film coated120 mg/1oralLake Erie Medical DBA Quality Care Products LLC1995-12-26Not applicableUs
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralSun Pharma Global FZE2011-10-31Not applicableUs
Diltiazem Hydrochloridetablet, film coated30 mg/1oralMylan Institutional Inc.1996-03-07Not applicableUs
Diltiazem Hydrochloridetablet, film coated120 mg/1oralMylan Pharmaceuticals Inc.1992-03-16Not applicableUs
Diltiazem Hydrochloridetablet, film coated90 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-12-04Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralTeva Pharmaceuticals USA Inc1995-12-22Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralMylan Institutional Inc.2000-10-01Not applicableUs
Diltiazem Hydrochloridetablet, film coated120 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Diltiazem Hydrochloridetablet, film coated30 mg/1oralCardinal Health1995-12-22Not applicableUs
Diltiazem Hydrochloridetablet, film coated120 mg/1oralREMEDYREPACK INC.2015-07-16Not applicableUs
Diltiazem Hydrochlorideinjection5 mg/mLintravenousWest Ward Pharmaceutical Corp.2008-12-17Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralRebel Distributors Corp1999-12-20Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralSun Pharma Global FZE2010-11-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralREMEDYREPACK INC.2011-11-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralActavis Elizabeth LLC1999-12-20Not applicableUs
Diltiazem Hydrochloridepowder, for solution100 mg/1intravenousHospira, Inc.2011-10-20Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-06-21Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralRebel Distributors Corp1999-12-20Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralMc Kesson Contract Packaging2011-09-22Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralAv Kare, Inc.2014-01-09Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralREMEDYREPACK INC.2011-06-21Not applicableUs
Diltiazem Hydrochloridecapsule, extended release90 mg/1oralMylan Institutional Inc.1999-12-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release60 mg/1oralMylan Pharmaceuticals Inc.1997-05-02Not applicableUs
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralActavis Elizabeth LLC2012-10-01Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralCardinal Health2010-01-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralPd Rx Pharmaceuticals, Inc.2011-09-08Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralSt Marys Medical Park Pharmacy2013-07-10Not applicableUs
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralAmerican Health Packaging2010-01-152016-03-01Us
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralSandoz Inc2012-10-01Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralDispensing Solutions, Inc.1999-12-20Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralAidarex Pharmaceuticals LLC1999-12-20Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralSun Pharma Global FZE2011-10-31Not applicableUs
Diltiazem Hydrochloridetablet, film coated30 mg/1oralMylan Pharmaceuticals Inc.1992-03-16Not applicableUs
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralTEVA Pharmaceuticals USA Inc.1999-12-28Not applicableUs
Diltiazem Hydrochloridetablet, film coated30 mg/1oralPhysicians Total Care, Inc.1995-04-24Not applicableUs
Diltiazem Hydrochloridetablet, film coated30 mg/1oralCardinal Health1992-11-05Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralActavis Elizabeth LLC2012-10-01Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralPhysicians Total Care, Inc.2004-06-03Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralCardinal Health2007-07-24Not applicableUs
Diltiazem Hydrochloridetablet, extended release300 mg/1oralWatson Pharma, Inc.2010-03-15Not applicableUs
Diltiazem Hydrochloridetablet, coated30 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-08-10Not applicableUs
Diltiazem Hydrochlorideinjection5 mg/mLintravenousAkorn, Inc.2013-11-12Not applicableUs
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralOceanside Pharmaceuticals1999-12-28Not applicableUs
Diltiazem Hydrochloridecapsule180 mg/1oralREMEDYREPACK INC.2011-08-03Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralMylan Institutional Inc.1996-03-07Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralMylan Pharmaceuticals Inc.1998-03-24Not applicableUs
Diltiazem Hydrochloridetablet, film coated120 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-12-04Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs
Diltiazem Hydrochloridetablet, film coated90 mg/1oralTeva Pharmaceuticals USA Inc1995-12-22Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralREMEDYREPACK INC.2013-03-15Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralA S Medication Solutions Llc1995-12-22Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralCardinal Health1995-12-22Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralApotex Corp.2001-07-30Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralAmerican Health Packaging2010-01-152016-03-01Us
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralSandoz Inc2012-10-01Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralREMEDYREPACK INC.2013-03-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralSun Pharma Global FZE2010-11-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralActavis Elizabeth LLC1999-12-24Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralSt Marys Medical Park Pharmacy2014-08-14Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-07-24Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralRebel Distributors Corp1999-12-20Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralREMEDYREPACK INC.2016-01-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralPd Rx Pharmaceuticals, Inc.1998-03-24Not applicableUs
Diltiazem Hydrochloridetablet30 mg/1oralREMEDYREPACK INC.2011-10-03Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralMylan Institutional Inc.1999-12-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release90 mg/1oralMylan Pharmaceuticals Inc.1997-05-02Not applicableUs
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralActavis Elizabeth LLC2012-10-01Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralAidarex Pharmaceuticals LLC2011-10-31Not applicableUs
Diltiazem Hydrochloridetablet, film coated120 mg/1oralPhysicians Total Care, Inc.2011-09-30Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralCardinal Health1992-11-05Not applicableUs
Diltiazem Hydrochloridetablet, extended release120 mg/1oralWatson Pharma, Inc.2010-03-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralbryant ranch prepack1999-12-28Not applicableUs
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralSandoz Inc2012-10-01Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralOceanside Pharmaceuticals1999-12-28Not applicableUs
Diltiazem Hydrochloridetablet, film coated120 mg/1oralAidarex Pharmaceuticals LLC1995-12-26Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralSun Pharma Global FZE2011-10-31Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralUnit Dose Services1995-12-22Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralMylan Pharmaceuticals Inc.1992-03-16Not applicableUs
Diltiazem Hydrochloridetablet, film coated30 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-12-04Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralTEVA Pharmaceuticals USA Inc.1999-12-28Not applicableUs
Diltiazem Hydrochloridetablet, film coated90 mg/1oralMylan Institutional Inc.1996-03-07Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralMylan Pharmaceuticals Inc.1998-03-24Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralActavis Elizabeth LLC2012-10-01Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralCardinal Health2010-01-15Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralPd Rx Pharmaceuticals, Inc.2011-11-10Not applicableUs
Diltiazem Hydrochloridetablet, extended release360 mg/1oralWatson Pharma, Inc.2010-03-15Not applicableUs
Diltiazem Hydrochloridetablet, coated60 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-08-10Not applicableUs
Diltiazem Hydrochlorideinjection5 mg/mLintravenousAkorn, Inc.2013-03-22Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralPreferred Pharmaceuticals, Inc.2011-03-31Not applicableUs
Diltiazem Hydrochloridetablet, film coated30 mg/1oralLake Erie Medical DBA Quality Care Products LLC1995-12-22Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralREMEDYREPACK INC.2011-04-11Not applicableUs
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralSun Pharma Global FZE2010-11-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralActavis Elizabeth LLC1999-12-20Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs
Diltiazem Hydrochloridetablet, film coated120 mg/1oralTeva Pharmaceuticals USA Inc1995-12-26Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralREMEDYREPACK INC.2012-09-28Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralPhysicians Total Care, Inc.2005-03-01Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralCardinal Health2011-07-11Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralApotex Corp.2001-07-30Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralAmerican Health Packaging2010-01-152016-03-01Us
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralSandoz Inc2012-10-01Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralAidarex Pharmaceuticals LLC1995-12-22Not applicableUs
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Diltiazem Hydrochloridetablet, film coated90 mg/1oralREMEDYREPACK INC.2015-06-16Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralDispensing Solutions, Inc.1999-12-20Not applicableUs
Diltiazem Hydrochloridetablet, film coated60 mg/1oralRebel Distributors Corp1992-11-05Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralSun Pharma Global FZE2010-11-15Not applicableUs
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralREMEDYREPACK INC.2013-03-20Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralMylan Institutional Inc.2000-10-01Not applicableUs
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralMylan Pharmaceuticals Inc.1997-05-02Not applicableUs
Diltiazem Hydrochlorideinjection5 mg/mLintravenousWest Ward Pharmaceutical Corp.2008-12-17Not applicableUs
Diltiazem Hydrochloridecapsule, extended release420 mg/1oralActavis Elizabeth LLC2012-10-01Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release240 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release120 mg/1oralCardinal Health2012-12-11Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release120 mg/1oralAmerican Health Packaging2012-12-11Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release240 mg/1oralPar Pharmaceutical, Inc.1999-12-20Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release240 mg/1oralCardinal Health1999-12-20Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release180 mg/1oralAmerican Health Packaging2012-12-11Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release300 mg/1oralPar Pharmaceutical, Inc.1999-12-24Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release180 mg/1oralLake Erie Medical DBA Quality Care Products LLC1999-12-20Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release240 mg/1oralAmerican Health Packaging2012-12-11Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release120 mg/1oralPar Pharmaceutical, Inc.1999-12-20Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release180 mg/1oralCardinal Health2012-12-11Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release180 mg/1oralPar Pharmaceutical, Inc.1999-12-20Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release300 mg/1oralAmerican Health Packaging2012-12-11Not applicableUs
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release240 mg/1oralCardinal Health2012-12-12Not applicableUs
Diltiazem Hydrochloride Extended Release Extended Releasecapsule, coated, extended release180 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs
Diltiazem Hydrochloride Extended Release Extended Releasecapsule, coated, extended release240 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs
Diltiazem Hydrochloride Extended Release Extended Releasecapsule, coated, extended release300 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs
Diltiazem Hydrochloride Extended Release Extended Releasecapsule, coated, extended release120 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs
Diltiazem Hydrochloride Extended-releasecapsule90 mg/1oralCardinal Health2011-08-16Not applicableUs
Diltiazem Hydrochlorideextended Release Extended Releasecapsule, coated, extended release240 mg/1oralREMEDYREPACK INC.2013-05-22Not applicableUs
Diltiazem Hydrochlorideextended Release Extended Releasecapsule, coated, extended release120 mg/1oralREMEDYREPACK INC.2013-11-18Not applicableUs
Diltiazem Hydrochlorideextended Release Extended Releasecapsule, coated, extended release240 mg/1oralREMEDYREPACK INC.2016-01-29Not applicableUs
Diltzaccapsule, extended release240 mg/1oralApotex Corp.2009-02-03Not applicableUs
Diltzaccapsule, extended release300 mg/1oralApotex Corp.2009-02-03Not applicableUs
Diltzaccapsule, extended release120 mg/1oralApotex Corp.2009-02-03Not applicableUs
Diltzaccapsule, extended release360 mg/1oralApotex Corp.2009-02-03Not applicableUs
Diltzaccapsule, extended release180 mg/1oralApotex Corp.2009-02-03Not applicableUs
Matzim LAtablet, extended release120 mg/1oralActavis Pharma, Inc.2011-03-28Not applicableUs
Matzim LAtablet, extended release360 mg/1oralActavis Pharma, Inc.2011-03-28Not applicableUs
Matzim LAtablet, extended release180 mg/1oralActavis Pharma, Inc.2011-03-28Not applicableUs
Matzim LAtablet, extended release420 mg/1oralActavis Pharma, Inc.2011-03-28Not applicableUs
Matzim LAtablet, extended release240 mg/1oralActavis Pharma, Inc.2011-03-28Not applicableUs
Matzim LAtablet, extended release300 mg/1oralActavis Pharma, Inc.2011-03-28Not applicableUs
Taztia Xtcapsule, extended release300 mg/1oralWatson Pharma, Inc.2003-04-10Not applicableUs
Taztia Xtcapsule, extended release360 mg/1oralWatson Pharma, Inc.2003-04-10Not applicableUs
Taztia Xtcapsule, extended release120 mg/1oralWatson Pharma, Inc.2003-04-10Not applicableUs
Taztia Xtcapsule, extended release180 mg/1oralWatson Pharma, Inc.2003-04-10Not applicableUs
Taztia Xtcapsule, extended release360 mg/1oralAmerican Health Packaging2015-03-31Not applicableUs
Taztia Xtcapsule, extended release240 mg/1oralWatson Pharma, Inc.2003-04-10Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Diltiazem HClinjection, solution1 mg/mLintravenousCantrell Drug Company2011-09-30Not applicableUs
Diltiazem HClinjection, solution.83 mg/mLintravenousCantrell Drug Company2013-10-22Not applicableUs
International Brands
NameCompany
AcalixRoemmers
AdizemMundipharma
AltiazemLusofarmaco
AnohealNot Available
CalcicardNot Available
CartiaNot Available
DilacorNot Available
Dilacor-XRWatson
DilcontinModi-Mundipharma
DilreneSanofi
Diltia XTNot Available
DilticardIntra
DilzemPfizer
HerbesserMitsubishi Tanabe
Incoril APBago
MasdilEsteve
SurazemNot Available
TAZTIANot Available
ViazemBiovail
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Diltiazem hydrochloride
ThumbNot applicableDBSALT000865
Diltiazem malate
ThumbNot applicableDBSALT001394
Categories
UNIIEE92BBP03H
CAS number42399-41-7
WeightAverage: 414.518
Monoisotopic: 414.16132802
Chemical FormulaC22H26N2O4S
InChI KeyInChIKey=HSUGRBWQSSZJOP-RTWAWAEBSA-N
InChI
InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
IUPAC Name
(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
SMILES
COC1=CC=C(C=C1)[C@@H]1SC2=CC=CC=C2N(CCN(C)C)C(=O)[C@@H]1OC(C)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzothiazepines. These are organic compounds containing a benzene fused to a thiazepine ring (a seven-membered ring with a nitrogen atom and a sulfur atom replacing two carbon atoms).
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzothiazepines
Sub ClassNot Available
Direct ParentBenzothiazepines
Alternative Parents
Substituents
  • Benzothiazepine
  • Methoxybenzene
  • Phenol ether
  • Anisole
  • Alkylarylthioether
  • Alkyl aryl ether
  • Benzenoid
  • Monocyclic benzene moiety
  • Acetate salt
  • Tertiary carboxylic acid amide
  • Tertiary aliphatic amine
  • Tertiary amine
  • Lactam
  • Carboxylic acid ester
  • Carboxamide group
  • Azacycle
  • Thioether
  • Ether
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
  • 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate (CHEBI:101278 )
Pharmacology
IndicationFor the treatment of Hypertension
PharmacodynamicsDiltiazem, a benzothiazepine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Diltiazem is a non-dihydropyridine (DHP)member of the calcium channel blocker class, along with Verapamil. Diltiazem is similar to other peripheral vasodilators. Diltiazem inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Mechanism of actionPossibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, diltiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.
Related Articles
AbsorptionDiltiazem is well absorbed from the gastrointestinal tract but undergoes substantial hepatic first-pass effect.
Volume of distributionNot Available
Protein binding70%-80%
Metabolism

Diltiazem is metabolized by and acts as an inhibitor of the CYP3A4 enzyme.

SubstrateEnzymesProduct
Diltiazem
N-DesmethyldiltiazemDetails
Route of eliminationNot Available
Half life3.0 - 4.5 hours
ClearanceNot Available
ToxicityLD50=740mg/kg (orally in mice)
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Diltiazem Action PathwayDrug actionSMP00359
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588
rs1801253 Not AvailableG > CBetter response to drug therapy22192668
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9788
Blood Brain Barrier+0.506
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.8645
P-glycoprotein inhibitor IInhibitor0.8675
P-glycoprotein inhibitor IIInhibitor0.8997
Renal organic cation transporterNon-inhibitor0.7634
CYP450 2C9 substrateNon-substrate0.699
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorInhibitor0.796
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8681
Ames testNon AMES toxic0.6985
CarcinogenicityNon-carcinogens0.8772
BiodegradationNot ready biodegradable0.9951
Rat acute toxicity2.4130 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9971
hERG inhibition (predictor II)Inhibitor0.7723
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Biovail laboratories inc
  • Watson laboratories inc florida
  • Watson laboratories inc
  • Apotex inc
  • Actavis elizabeth llc
  • Kv pharmaceutical co
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Packagers
Dosage forms
FormRouteStrength
Capsule (controlled-delivery)oral120 mg
Capsule (controlled-delivery)oral180 mg
Capsule (controlled-delivery)oral240 mg
Capsule (controlled-delivery)oral300 mg
Capsule (sustained-release)oral90 mg
Capsule (sustained-release)oral120 mg
Capsule (sustained-release)oral60 mg
Tablet, coatedoral120 mg/1
Tablet, coatedoral30 mg/1
Tablet, coatedoral60 mg/1
Capsuleoral240 mg/1
Capsule (extended release)oral120 mg
Capsule (extended release)oral180 mg
Capsule (extended release)oral240 mg
Capsule (extended release)oral300 mg
Capsule, coated, extended releaseoral120 mg/1
Capsule, coated, extended releaseoral180 mg/1
Capsule, coated, extended releaseoral240 mg/1
Capsule, coated, extended releaseoral300 mg/1
Capsule, coated, extended releaseoral360 mg/1
Liquidintravenous5 mg
Tablet, extended releaseoral120 mg/1
Tablet, extended releaseoral180 mg/1
Tablet, extended releaseoral240 mg/1
Tablet, extended releaseoral300 mg/1
Tablet, extended releaseoral360 mg/1
Tablet, extended releaseoral420 mg/1
Capsuleoral120 mg/1
Capsuleoral300 mg/1
Injection, solutionintravenous.83 mg/mL
Injection, solutionintravenous1 mg/mL
Capsuleoral180 mg/1
Capsule, extended releaseoral120 mg/1
Capsule, extended releaseoral180 mg/1
Capsule, extended releaseoral240 mg/1
Capsule, extended releaseoral300 mg/1
Capsule, extended releaseoral60 mg/1
Capsule, extended releaseoral90 mg/1
Injectionintravenous5 mg/mL
Injection, solutionintravenous5 mg/mL
Powder, for solutionintravenous100 mg/1
Tabletoral30 mg/1
Tablet, film coatedoral120 mg/1
Tablet, film coatedoral30 mg/1
Tablet, film coatedoral60 mg/1
Tablet, film coatedoral90 mg/1
Capsuleoral90 mg/1
Solutionintravenous5 mg
Tabletoral30 mg
Tabletoral60 mg
Capsule (extended release)oral360 mg
Capsule, extended releaseoral360 mg/1
Capsule, extended releaseoral420 mg/1
Tablet (extended-release)oral120 mg
Tablet (extended-release)oral180 mg
Tablet (extended-release)oral240 mg
Tablet (extended-release)oral300 mg
Tablet (extended-release)oral360 mg
Prices
Unit descriptionCostUnit
Cormax 0.05% Solution 50ml Bottle81.6USD bottle
Cormax 0.05% Solution 25ml Bottle45.99USD bottle
Cormax 0.05% Cream 15 gm Tube43.98USD tube
Diltiazem hcl 100 mg vial9.54USD vial
Diltiazem hcl powder8.42USD g
Cardizem CD 360 mg 24 Hour Capsule7.94USD capsule
Cardizem cd 360 mg capsule7.63USD capsule
Cardizem CD 300 mg 24 Hour Capsule7.3USD capsule
Cardizem LA 420 mg 24 Hour tablet5.56USD tablet
Cardizem CD 240 mg 24 Hour Capsule5.48USD capsule
Cardizem la 420 mg tablet5.35USD tablet
Diltiazem HCl Coated Beads 420 mg 24 Hour tablet5.01USD tablet
Cardizem la 360 mg tablet4.94USD tablet
Cardizem LA 360 mg 24 Hour tablet4.81USD tablet
Cardizem LA 300 mg 24 Hour tablet4.71USD tablet
Diltiazem HCl Coated Beads 360 mg 24 Hour tablet4.62USD tablet
Cardizem la 300 mg tablet4.59USD tablet
Diltiazem HCl Coated Beads 300 mg 24 Hour tablet4.3USD tablet
Cardizem CD 180 mg 24 Hour Capsule3.98USD capsule
Tiazac 420 mg 24 Hour Capsule3.88USD capsule
Tiazac 360 mg 24 Hour Capsule3.7USD capsule
Cardizem LA 240 mg 24 Hour tablet3.67USD tablet
Tiazac 300 mg 24 Hour Capsule3.64USD capsule
Cardizem la 240 mg tablet3.53USD tablet
Cardizem 120 mg tablet3.49USD tablet
Cardizem CD 120 mg 24 Hour Capsule3.4USD capsule
Dilacor XR 180 mg 24 Hour Capsule3.3USD capsule
Dilacor XR 240 mg 24 Hour Capsule3.3USD capsule
Diltiazem HCl Coated Beads 240 mg 24 Hour tablet3.3USD tablet
Dilacor xr 240 mg capsule3.29USD capsule
Cardizem Cd 300 mg Controlled-Delivery Capsule3.25USD capsule
Cardizem la 180 mg tablet3.15USD tablet
Cardizem LA 180 mg 24 Hour tablet3.07USD tablet
Dilacor xr 180 mg capsule3.07USD capsule
Tiazac er 420 mg capsule3.03USD capsule
Cardizem la 120 mg tablet2.98USD tablet
Diltiazem HCl Coated Beads 180 mg 24 Hour tablet2.95USD tablet
Diltiazem HCl ER Beads 420 mg 24 Hour Capsule2.87USD capsule
Dilacor XR 120 mg 24 Hour Capsule2.86USD capsule
Tiazac er 360 mg capsule2.86USD capsule
Tiazac er 300 mg capsule2.83USD capsule
Tiazac 240 mg 24 Hour Capsule2.8USD capsule
Cartia XT 300 mg 24 Hour Capsule2.76USD capsule
Dilt-CD 300 mg 24 Hour Capsule2.76USD capsule
Diltiazem HCl Coated Beads 300 mg 24 Hour Capsule2.76USD capsule
Cormax 0.05% cream2.71USD g
Cartia xt 300 mg capsule2.66USD capsule
Dilt-cd er 300 mg capsule2.66USD capsule
Dilacor xr 120 mg capsule2.61USD capsule
Cardizem Cd 240 mg Controlled-Delivery Capsule2.6USD capsule
Diltiazem HCl ER Beads 360 mg 24 Hour Capsule2.44USD capsule
Tiazac 360 mg Extended-Release Capsule2.42USD capsule
Diltiazem HCl ER Beads 300 mg 24 Hour Capsule2.39USD capsule
Cardizem LA 120 mg 24 Hour tablet2.35USD tablet
Tiazac 240 mg capsule sa2.31USD capsule
Tiazac er 240 mg capsule2.18USD capsule
Cardizem cd 300 mg capsule2.15USD capsule
Cartia XT 240 mg 24 Hour Capsule2.13USD capsule
Diltiazem HCl Coated Beads 240 mg 24 Hour Capsule2.13USD capsule
Dilt-cd 240 mg capsule2.05USD capsule
Cardizem 90 mg tablet2.02USD tablet
Tiazac 180 mg 24 Hour Capsule1.98USD capsule
Tiazac 300 mg Extended-Release Capsule1.98USD capsule
Cardizem Cd 180 mg Controlled-Delivery Capsule1.96USD capsule
Diltiazem HCl ER Beads 240 mg 24 Hour Capsule1.85USD capsule
Cardizem sr 120 mg capsule1.83USD capsule
Apo-Diltiaz Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Novo-Diltazem Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Ratio-Diltiazem Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Sandoz Diltiazem Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Cardizem cd 240 mg capsule1.69USD capsule
Tiazac 120 mg 24 Hour Capsule1.69USD capsule
Tiazac 240 mg Extended-Release Capsule1.61USD capsule
Tiazac er 180 mg capsule1.52USD capsule
Cartia XT 180 mg 24 Hour Capsule1.5USD capsule
Dilt-CD 180 mg 24 Hour Capsule1.5USD capsule
Diltiazem HCl Coated Beads 180 mg 24 Hour Capsule1.5USD capsule
Cardizem Cd 120 mg Controlled-Delivery Capsule1.48USD capsule
Apo-Diltiaz Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Novo-Diltazem Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Nu-Diltiaz-Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Ratio-Diltiazem Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Sandoz Diltiazem Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Tiazac Xc 240 mg Extended-Release Tablet1.46USD tablet
Tiazac Xc 300 mg Extended-Release Tablet1.46USD tablet
Tiazac Xc 360 mg Extended-Release Tablet1.46USD tablet
Dilt-cd 180 mg capsule1.45USD capsule
Diltiazem HCl 120 mg tablet1.42USD tablet
Diltiazem 120 mg tablet1.36USD tablet
Apo-Diltiaz Tz 360 mg Extended-Release Capsule1.36USD capsule
Novo-Diltiazem Hcl Er 360 mg Extended-Release Capsule1.36USD capsule
Sandoz Diltiazem T 360 mg Extended-Release Capsule1.36USD capsule
Cardizem 30 mg tablet1.34USD tablet
Diltiazem HCl ER Beads 180 mg 24 Hour Capsule1.3USD capsule
Diltiazem HCl CR 120 mg 12 Hour Capsule1.29USD capsule
Tiazac er 120 mg capsule1.26USD capsule
Cartia XT 120 mg 24 Hour Capsule1.25USD capsule
Dilt-CD 120 mg 24 Hour Capsule1.25USD capsule
Diltiazem HCl Coated Beads 120 mg 24 Hour Capsule1.25USD capsule
Cardizem cd 180 mg capsule1.24USD capsule
Tiazac 180 mg Extended-Release Capsule1.21USD capsule
Cartia xt 120 mg capsule1.2USD capsule
Dilt-cd 120 mg capsule1.2USD capsule
Diltiazem HCl CR 240 mg 24 Hour Capsule1.19USD capsule
Diltia XT 240 mg 24 Hour Capsule1.17USD capsule
Diltiazem HCl CR 180 mg 24 Hour Capsule1.11USD capsule
Apo-Diltiaz Tz 300 mg Extended-Release Capsule1.11USD capsule
Novo-Diltiazem Hcl Er 300 mg Extended-Release Capsule1.11USD capsule
Sandoz Diltiazem T 300 mg Extended-Release Capsule1.11USD capsule
Tiazac Xc 180 mg Extended-Release Tablet1.1USD tablet
Diltia XT 180 mg 24 Hour Capsule1.1USD capsule
Apo-Diltiaz Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Novo-Diltazem Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Nu-Diltiaz-Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Ratio-Diltiazem Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Sandoz Diltiazem Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Diltiazem HCl ER Beads 120 mg 24 Hour Capsule1.08USD capsule
Diltiazem HCl 90 mg tablet1.05USD tablet
Diltiazem 90 mg tablet1.01USD tablet
Diltiazem HCl CR 90 mg 12 Hour Capsule0.99USD capsule
Cardizem cd 120 mg capsule0.97USD capsule
Cardizem 60 mg tablet0.95USD tablet
Diltiazem HCl CR 120 mg 24 Hour Capsule0.95USD capsule
Apo-Diltiaz Tz 240 mg Extended-Release Capsule0.9USD capsule
Novo-Diltiazem Hcl Er 240 mg Extended-Release Capsule0.9USD capsule
Sandoz Diltiazem T 240 mg Extended-Release Capsule0.9USD capsule
Tiazac 120 mg Extended-Release Capsule0.89USD capsule
Diltiazem HCl CR 60 mg 12 Hour Capsule0.86USD capsule
Apo-Diltiaz Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Novo-Diltazem Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Nu-Diltiaz-Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Ratio-Diltiazem Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Sandoz Diltiazem Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Tiazac Xc 120 mg Extended-Release Tablet0.83USD tablet
Cartia xt 240 mg capsule0.81USD capsule
Diltiazem HCl 60 mg tablet0.77USD tablet
Diltiazem 60 mg tablet0.74USD tablet
Apo-Diltiaz Tz 180 mg Extended-Release Capsule0.68USD capsule
Novo-Diltiazem Hcl Er 180 mg Extended-Release Capsule0.68USD capsule
Sandoz Diltiazem T 180 mg Extended-Release Capsule0.68USD capsule
Cartia xt 180 mg capsule0.6USD capsule
Apo-Diltiaz Tz 120 mg Extended-Release Capsule0.5USD capsule
Novo-Diltiazem Hcl Er 120 mg Extended-Release Capsule0.5USD capsule
Sandoz Diltiazem T 120 mg Extended-Release Capsule0.5USD capsule
Diltiazem HCl 30 mg tablet0.49USD tablet
Diltiazem 30 mg tablet0.47USD tablet
Diltia xt 240 mg capsule0.43USD capsule
Diltia xt 180 mg capsule0.42USD capsule
Diltiazem-d5w 250 mg/250 ml0.42USD ml
Diltia xt 120 mg capsule0.38USD capsule
Apo-Diltiaz 60 mg Tablet0.38USD tablet
Novo-Diltazem 60 mg Tablet0.38USD tablet
Nu-Diltiaz 60 mg Tablet0.38USD tablet
Apo-Diltiaz 30 mg Tablet0.22USD tablet
Novo-Diltazem 30 mg Tablet0.22USD tablet
Nu-Diltiaz 30 mg Tablet0.22USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2111085 No1999-04-272012-06-25Canada
CA2307547 No2007-08-142020-05-04Canada
US5286497 No1994-05-202011-05-20Us
US6923984 No2001-02-252021-02-25Us
US7108866 No1999-12-172019-12-17Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point187-188Kugita, H., Inoue, H., Ikezaki, M. and Takeo, S.; U.S. Patent 3,562,257; assigned to Tanabe Seiyaku Co.,Ltd., Japan.
water solubility465 mg/L (at 25 °C)MCFARLAND,JW ET AL. (2001)
logP2.8Not Available
Caco2 permeability-4.38ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.0168 mg/mLALOGPS
logP3.09ALOGPS
logP2.73ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)12.86ChemAxon
pKa (Strongest Basic)8.18ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area59.08 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity114.37 m3·mol-1ChemAxon
Polarizability43.65 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-0ab9-9200000000-b1095b8fe5973d23fdd6View in MoNA
References
Synthesis Reference

Kugita, H., Inoue, H., Ikezaki, M. and Takeo, S.; U.S. Patent 3,562,257; assigned to Tanabe Seiyaku Co.,Ltd., Japan.

US3562257
General ReferencesNot Available
External Links
ATC CodesC05AE03C08DB01
AHFS Codes
  • 24:28.92
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.2 KB)
Interactions
Drug Interactions
Drug
2-HYDROXY-1,4-NAPHTHOQUINONEThe risk or severity of adverse effects can be increased when 2-HYDROXY-1,4-NAPHTHOQUINONE is combined with Diltiazem.
2-mercaptobenzothiazoleThe risk or severity of adverse effects can be increased when 2-mercaptobenzothiazole is combined with Diltiazem.
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypotensive activities of Diltiazem.
AbirateroneThe serum concentration of Diltiazem can be increased when it is combined with Abiraterone.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Diltiazem.
AcebutololDiltiazem may increase the hypotensive activities of Acebutolol.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Diltiazem.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Diltiazem.
AcetaminophenThe serum concentration of Diltiazem can be increased when it is combined with Acetaminophen.
AcetazolamideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Acetazolamide.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Diltiazem.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Diltiazem.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Diltiazem.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Diltiazem.
AlbendazoleThe serum concentration of Diltiazem can be increased when it is combined with Albendazole.
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Diltiazem.
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Diltiazem.
AldosteroneThe serum concentration of Diltiazem can be decreased when it is combined with Aldosterone.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Diltiazem.
AlectinibThe serum concentration of Diltiazem can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Diltiazem.
AlfuzosinAlfuzosin may increase the hypotensive activities of Diltiazem.
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Diltiazem.
AliskirenDiltiazem may increase the hypotensive activities of Aliskiren.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Diltiazem.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Diltiazem.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Diltiazem.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Diltiazem.
AlosetronThe metabolism of Alosetron can be decreased when combined with Diltiazem.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Diltiazem.
AlprenololDiltiazem may increase the hypotensive activities of Alprenolol.
AmantadineThe serum concentration of Diltiazem can be increased when it is combined with Amantadine.
AmbrisentanDiltiazem may increase the hypotensive activities of Ambrisentan.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Diltiazem.
AmifostineDiltiazem may increase the hypotensive activities of Amifostine.
AmilorideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Amiloride.
Aminohippuric acidThe serum concentration of Diltiazem can be increased when it is combined with Aminohippuric acid.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Diltiazem.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Diltiazem.
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Diltiazem.
AmiodaroneThe serum concentration of Diltiazem can be decreased when it is combined with Amiodarone.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Diltiazem.
AmitriptylineThe serum concentration of Diltiazem can be increased when it is combined with Amitriptyline.
AmlodipineDiltiazem may increase the hypotensive activities of Amlodipine.
AmobarbitalAmobarbital may increase the hypotensive activities of Diltiazem.
AmorolfineThe risk or severity of adverse effects can be increased when Amorolfine is combined with Diltiazem.
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Diltiazem.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Diltiazem.
AmprenavirThe serum concentration of Diltiazem can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Diltiazem can be increased when it is combined with Amsacrine.
Amyl NitriteThe risk or severity of adverse effects can be increased when Diltiazem is combined with Amyl Nitrite.
AN2690The risk or severity of adverse effects can be increased when AN2690 is combined with Diltiazem.
AnidulafunginThe risk or severity of adverse effects can be increased when Anidulafungin is combined with Diltiazem.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Diltiazem.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Diltiazem.
ApraclonidineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Apraclonidine.
ApremilastThe metabolism of Apremilast can be decreased when combined with Diltiazem.
AprepitantThe serum concentration of Diltiazem can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Diltiazem.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Diltiazem.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Diltiazem.
AripiprazoleAripiprazole may increase the hypotensive activities of Diltiazem.
ArmodafinilThe metabolism of Diltiazem can be decreased when combined with Armodafinil.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Diltiazem.
ArtemetherThe metabolism of Artemether can be decreased when combined with Diltiazem.
AsenapineThe metabolism of Asenapine can be decreased when combined with Diltiazem.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Diltiazem.
AstemizoleThe serum concentration of Diltiazem can be increased when it is combined with Astemizole.
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Diltiazem.
AtazanavirThe serum concentration of Diltiazem can be increased when it is combined with Atazanavir.
AtenololAtenolol may increase the hypotensive activities of Diltiazem.
AtomoxetineThe metabolism of Diltiazem can be decreased when combined with Atomoxetine.
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Diltiazem.
AtorvastatinThe serum concentration of Diltiazem can be increased when it is combined with Atorvastatin.
AtosibanThe risk or severity of adverse effects can be increased when Diltiazem is combined with Atosiban.
Atracurium besylateDiltiazem may increase the neuromuscular blocking activities of Atracurium besylate.
AvanafilThe metabolism of Avanafil can be decreased when combined with Diltiazem.
AxitinibThe metabolism of Axitinib can be decreased when combined with Diltiazem.
AzelastineThe metabolism of Azelastine can be decreased when combined with Diltiazem.
AzelastineThe serum concentration of Diltiazem can be increased when it is combined with Azelastine.
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Diltiazem is combined with Azilsartan medoxomil.
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Diltiazem.
AzithromycinThe serum concentration of Diltiazem can be increased when it is combined with Azithromycin.
Bafilomycin A1The risk or severity of adverse effects can be increased when Bafilomycin A1 is combined with Diltiazem.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Diltiazem.
BarbitalBarbital may increase the hypotensive activities of Diltiazem.
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Diltiazem.
BenazeprilDiltiazem may increase the hypotensive activities of Benazepril.
BendroflumethiazideDiltiazem may increase the hypotensive activities of Bendroflumethiazide.
BenmoxinBenmoxin may increase the hypotensive activities of Diltiazem.
BenzocaineThe serum concentration of Diltiazem can be increased when it is combined with Benzocaine.
Benzoic AcidThe risk or severity of adverse effects can be increased when Benzoic Acid is combined with Diltiazem.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Diltiazem.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Diltiazem.
BepridilDiltiazem may increase the hypotensive activities of Bepridil.
BeractantDiltiazem may increase the bradycardic activities of Beractant.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Diltiazem.
BetaxololBetaxolol may increase the hypotensive activities of Diltiazem.
BethanidineBethanidine may increase the hypotensive activities of Diltiazem.
BexaroteneThe serum concentration of Diltiazem can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Diltiazem.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Diltiazem.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Diltiazem.
BifonazoleThe risk or severity of adverse effects can be increased when Bifonazole is combined with Diltiazem.
BimatoprostDiltiazem may increase the hypotensive activities of Bimatoprost.
BiperidenThe serum concentration of Diltiazem can be increased when it is combined with Biperiden.
BisoprololDiltiazem may increase the hypotensive activities of Bisoprolol.
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Diltiazem.
BortezomibThe metabolism of Diltiazem can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Diltiazem can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Diltiazem.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Diltiazem.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Diltiazem.
BretyliumBretylium may increase the bradycardic activities of Diltiazem.
BretyliumDiltiazem may increase the hypotensive activities of Bretylium.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Diltiazem.
BrimonidineDiltiazem may increase the hypotensive activities of Brimonidine.
BrimonidineBrimonidine may increase the antihypertensive activities of Diltiazem.
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Diltiazem.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Diltiazem.
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Diltiazem.
BromocriptineThe serum concentration of Diltiazem can be increased when it is combined with Bromocriptine.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Diltiazem.
BudesonideThe metabolism of Budesonide can be decreased when combined with Diltiazem.
BumetanideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Bumetanide.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Diltiazem.
BupranololDiltiazem may increase the hypotensive activities of Bupranolol.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Diltiazem.
BuprenorphineThe serum concentration of Diltiazem can be increased when it is combined with Buprenorphine.
BupropionThe metabolism of Bupropion can be decreased when combined with Diltiazem.
BuspironeThe metabolism of Buspirone can be decreased when combined with Diltiazem.
BuspironeThe serum concentration of Diltiazem can be increased when it is combined with Buspirone.
BusulfanThe metabolism of Busulfan can be decreased when combined with Diltiazem.
ButenafineThe risk or severity of adverse effects can be increased when Butenafine is combined with Diltiazem.
ButoconazoleThe risk or severity of adverse effects can be increased when Butoconazole is combined with Diltiazem.
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Diltiazem.
CabazitaxelThe serum concentration of Diltiazem can be increased when it is combined with Cabazitaxel.
CabergolineThe metabolism of Cabergoline can be decreased when combined with Diltiazem.
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Diltiazem.
CaffeineThe metabolism of Caffeine can be decreased when combined with Diltiazem.
CaffeineThe serum concentration of Diltiazem can be increased when it is combined with Caffeine.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Diltiazem.
CalfactantDiltiazem may increase the bradycardic activities of Calfactant.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Diltiazem.
CanagliflozinThe risk or severity of adverse effects can be increased when Diltiazem is combined with Canagliflozin.
CandesartanDiltiazem may increase the hypotensive activities of Candesartan.
CandicidinThe risk or severity of adverse effects can be increased when Candicidin is combined with Diltiazem.
CandoxatrilDiltiazem may increase the hypotensive activities of Candoxatril.
CapecitabineThe metabolism of Diltiazem can be decreased when combined with Capecitabine.
CaptoprilDiltiazem may increase the hypotensive activities of Captopril.
CarbamazepineThe metabolism of Carbamazepine can be decreased when combined with Diltiazem.
CarbamazepineThe serum concentration of Diltiazem can be decreased when it is combined with Carbamazepine.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Diltiazem.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Diltiazem.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Diltiazem.
CaroxazoneCaroxazone may increase the hypotensive activities of Diltiazem.
CarteololDiltiazem may increase the hypotensive activities of Carteolol.
CarvedilolDiltiazem may increase the hypotensive activities of Carvedilol.
CaspofunginThe serum concentration of Diltiazem can be increased when it is combined with Caspofungin.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Diltiazem.
CeliprololDiltiazem may increase the hypotensive activities of Celiprolol.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Diltiazem.
CeritinibDiltiazem may increase the bradycardic activities of Ceritinib.
CeritinibThe serum concentration of Diltiazem can be increased when it is combined with Ceritinib.
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Diltiazem.
CeruleninThe risk or severity of adverse effects can be increased when Cerulenin is combined with Diltiazem.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Diltiazem.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Diltiazem.
ChloramphenicolThe metabolism of Diltiazem can be decreased when combined with Chloramphenicol.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Diltiazem.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Diltiazem.
ChloroquineThe serum concentration of Diltiazem can be increased when it is combined with Chloroquine.
ChlorothiazideDiltiazem may increase the hypotensive activities of Chlorothiazide.
ChloroxineThe risk or severity of adverse effects can be increased when Chloroxine is combined with Diltiazem.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Diltiazem.
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Diltiazem.
ChlorpromazineThe serum concentration of Diltiazem can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Diltiazem can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Diltiazem can be increased when it is combined with Chlorprothixene.
ChlorthalidoneChlorthalidone may increase the hypotensive activities of Diltiazem.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Diltiazem.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Diltiazem.
CholesterolThe serum concentration of Diltiazem can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Diltiazem can be decreased when it is combined with Cholic Acid.
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Diltiazem.
CiclopiroxThe risk or severity of adverse effects can be increased when Ciclopirox is combined with Diltiazem.
CilazaprilDiltiazem may increase the hypotensive activities of Cilazapril.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Diltiazem.
CimetidineThe serum concentration of Diltiazem can be decreased when it is combined with Cimetidine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Diltiazem.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Diltiazem.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Diltiazem.
CisaprideThe metabolism of Cisapride can be decreased when combined with Diltiazem.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Diltiazem.
CitalopramThe metabolism of Citalopram can be decreased when combined with Diltiazem.
CitalopramThe serum concentration of Diltiazem can be increased when it is combined with Citalopram.
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Diltiazem.
ClarithromycinThe serum concentration of Diltiazem can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Diltiazem can be decreased when combined with Clemastine.
ClevidipineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Clevidipine.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Diltiazem.
ClobazamThe metabolism of Clobazam can be decreased when combined with Diltiazem.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Diltiazem.
ClofazimineThe serum concentration of Diltiazem can be increased when it is combined with Clofazimine.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Diltiazem.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Diltiazem.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Diltiazem.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Diltiazem.
ClomipramineThe serum concentration of Diltiazem can be increased when it is combined with Clomipramine.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Diltiazem.
ClonidineDiltiazem may increase the hypotensive activities of Clonidine.
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Diltiazem.
ClopidogrelThe metabolism of Diltiazem can be decreased when combined with Clopidogrel.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Diltiazem.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Diltiazem.
ClotrimazoleThe metabolism of Diltiazem can be decreased when combined with Clotrimazole.
ClozapineThe metabolism of Clozapine can be decreased when combined with Diltiazem.
CobicistatThe serum concentration of Diltiazem can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Diltiazem.
CocaineThe metabolism of Cocaine can be decreased when combined with Diltiazem.
CodeineThe metabolism of Codeine can be decreased when combined with Diltiazem.
ColchicineThe metabolism of Colchicine can be decreased when combined with Diltiazem.
ColchicineThe serum concentration of Diltiazem can be increased when it is combined with Colchicine.
ColestipolColestipol can cause a decrease in the absorption of Diltiazem resulting in a reduced serum concentration and potentially a decrease in efficacy.
ColforsinThe serum concentration of Diltiazem can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Diltiazem can be increased when it is combined with Conivaptan.
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Diltiazem.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Diltiazem.
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Diltiazem.
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Diltiazem.
CryptenamineDiltiazem may increase the hypotensive activities of Cryptenamine.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Diltiazem.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Diltiazem.
CyclophosphamideThe serum concentration of Diltiazem can be increased when it is combined with Cyclophosphamide.
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Diltiazem.
CyclothiazideDiltiazem may increase the hypotensive activities of Cyclothiazide.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Diltiazem.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Diltiazem.
DabrafenibThe serum concentration of Diltiazem can be decreased when it is combined with Dabrafenib.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Diltiazem.
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Diltiazem.
DaclatasvirThe serum concentration of Diltiazem can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Diltiazem.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Diltiazem.
DapagliflozinThe risk or severity of adverse effects can be increased when Diltiazem is combined with Dapagliflozin.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Diltiazem.
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Diltiazem.
DapsoneThe metabolism of Dapsone can be decreased when combined with Diltiazem.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Diltiazem.
DarunavirThe serum concentration of Diltiazem can be increased when it is combined with Darunavir.
DarunavirThe metabolism of Darunavir can be decreased when combined with Diltiazem.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Diltiazem.
DasatinibThe serum concentration of Diltiazem can be increased when it is combined with Dasatinib.
DasatinibThe metabolism of Dasatinib can be decreased when combined with Diltiazem.
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Diltiazem.
DaunorubicinThe serum concentration of Diltiazem can be decreased when it is combined with Daunorubicin.
DebrisoquinDiltiazem may increase the hypotensive activities of Debrisoquin.
Decanoic AcidThe risk or severity of adverse effects can be increased when Decanoic Acid is combined with Diltiazem.
DeferasiroxThe serum concentration of Diltiazem can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe metabolism of Dehydroepiandrosterone can be decreased when combined with Diltiazem.
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Diltiazem.
DeserpidineDiltiazem may increase the hypotensive activities of Deserpidine.
DesipramineThe serum concentration of Diltiazem can be increased when it is combined with Desipramine.
DesloratadineThe serum concentration of Diltiazem can be increased when it is combined with Desloratadine.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Diltiazem.
DexamethasoneThe serum concentration of Diltiazem can be decreased when it is combined with Dexamethasone.
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Diltiazem.
DexmedetomidineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Dexmedetomidine.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Diltiazem.
DextromethorphanThe serum concentration of Diltiazem can be increased when it is combined with Dextromethorphan.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Diltiazem.
DiazepamThe metabolism of Diazepam can be decreased when combined with Diltiazem.
DiazoxideDiazoxide may increase the hypotensive activities of Diltiazem.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Diltiazem.
DiclofenacThe serum concentration of Diltiazem can be increased when it is combined with Diclofenac.
DiclofenamideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Diclofenamide.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Diltiazem.
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Diltiazem.
DigoxinThe metabolism of Digoxin can be decreased when combined with Diltiazem.
DigoxinThe serum concentration of Diltiazem can be decreased when it is combined with Digoxin.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Diltiazem.
DihydroergotamineThe metabolism of Diltiazem can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Diltiazem.
DinutuximabThe risk or severity of adverse effects can be increased when Diltiazem is combined with Dinutuximab.
DiphenhydramineThe metabolism of Diltiazem can be decreased when combined with Diphenhydramine.
DipyridamoleThe risk or severity of adverse effects can be increased when Diltiazem is combined with Dipyridamole.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Diltiazem.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Diltiazem.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Diltiazem.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Diltiazem.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Diltiazem.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Diltiazem.
DonepezilThe metabolism of Donepezil can be decreased when combined with Diltiazem.
DonepezilDonepezil may increase the bradycardic activities of Diltiazem.
DorzolamideDiltiazem may increase the hypotensive activities of Dorzolamide.
DoxazosinDiltiazem may increase the hypotensive activities of Doxazosin.
DoxepinThe metabolism of Doxepin can be decreased when combined with Diltiazem.
DoxepinThe serum concentration of Diltiazem can be increased when it is combined with Doxepin.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Diltiazem.
DoxorubicinThe serum concentration of Diltiazem can be decreased when it is combined with Doxorubicin.
DoxycyclineThe metabolism of Diltiazem can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Diltiazem.
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Diltiazem.
DuloxetineDiltiazem may increase the orthostatic hypotensive activities of Duloxetine.
DuloxetineThe metabolism of Diltiazem can be decreased when combined with Duloxetine.
DutasterideThe metabolism of Dutasteride can be decreased when combined with Diltiazem.
EconazoleThe risk or severity of adverse effects can be increased when Econazole is combined with Diltiazem.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Diltiazem.
EfavirenzThe serum concentration of Diltiazem can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Diltiazem.
EfinaconazoleThe risk or severity of adverse effects can be increased when Efinaconazole is combined with Diltiazem.
EfonidipineDiltiazem may increase the hypotensive activities of Efonidipine.
ElbasvirThe serum concentration of Diltiazem can be increased when it is combined with Elbasvir.
EletriptanThe metabolism of Eletriptan can be decreased when combined with Diltiazem.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Diltiazem.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Diltiazem.
EmpagliflozinThe risk or severity of adverse effects can be increased when Diltiazem is combined with Empagliflozin.
EnalaprilDiltiazem may increase the hypotensive activities of Enalapril.
EnalaprilatDiltiazem may increase the hypotensive activities of Enalaprilat.
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Diltiazem.
EnzalutamideThe serum concentration of Diltiazem can be increased when it is combined with Enzalutamide.
EpinastineThe metabolism of Epinastine can be decreased when combined with Diltiazem.
EplerenoneThe risk or severity of adverse effects can be increased when Diltiazem is combined with Eplerenone.
EpoprostenolDiltiazem may increase the hypotensive activities of Epoprostenol.
EprosartanDiltiazem may increase the hypotensive activities of Eprosartan.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Diltiazem.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Diltiazem.
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Diltiazem.
ErgonovineThe serum concentration of Diltiazem can be increased when it is combined with Ergonovine.
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Diltiazem.
ErgotamineThe serum concentration of Diltiazem can be increased when it is combined with Ergotamine.
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Diltiazem.
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Diltiazem.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Diltiazem.
Eslicarbazepine acetateThe serum concentration of Diltiazem can be decreased when it is combined with Eslicarbazepine acetate.
EsmololThe risk or severity of adverse effects can be increased when Esmolol is combined with Diltiazem.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Diltiazem.
EstazolamThe metabolism of Estazolam can be decreased when combined with Diltiazem.
EstradiolThe metabolism of Estradiol can be decreased when combined with Diltiazem.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Diltiazem.
EstramustineThe metabolism of Estramustine can be decreased when combined with Diltiazem.
EstramustineThe serum concentration of Diltiazem can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Diltiazem can be decreased when it is combined with Estriol.
EstriolThe serum concentration of Estriol can be increased when it is combined with Diltiazem.
EstroneThe metabolism of Estrone can be decreased when combined with Diltiazem.
EstroneThe serum concentration of Diltiazem can be decreased when it is combined with Estrone.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Diltiazem.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Diltiazem.
Etacrynic acidThe risk or severity of adverse effects can be increased when Diltiazem is combined with Etacrynic acid.
EthanolThe metabolism of Ethanol can be decreased when combined with Diltiazem.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Diltiazem.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Diltiazem.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Diltiazem.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Diltiazem.
EtoposideThe metabolism of Etoposide can be decreased when combined with Diltiazem.
EtoposideThe serum concentration of Diltiazem can be increased when it is combined with Etoposide.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Diltiazem.
EtravirineThe serum concentration of Diltiazem can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Diltiazem.
EverolimusThe metabolism of Everolimus can be decreased when combined with Diltiazem.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Diltiazem.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Diltiazem.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Diltiazem.
FelbamateThe metabolism of Felbamate can be decreased when combined with Diltiazem.
FelodipineDiltiazem may increase the hypotensive activities of Felodipine.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Diltiazem.
FenoldopamDiltiazem may increase the hypotensive activities of Fenoldopam.
FentanylThe metabolism of Fentanyl can be decreased when combined with Diltiazem.
FentanylThe serum concentration of Diltiazem can be increased when it is combined with Fentanyl.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Diltiazem.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Diltiazem.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Diltiazem.
FinasterideThe metabolism of Finasteride can be decreased when combined with Diltiazem.
FingolimodDiltiazem may increase the bradycardic activities of Fingolimod.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Diltiazem.
FloxuridineThe metabolism of Diltiazem can be decreased when combined with Floxuridine.
FluconazoleThe serum concentration of Diltiazem can be increased when it is combined with Fluconazole.
FlucytosineThe risk or severity of adverse effects can be increased when Flucytosine is combined with Diltiazem.
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Diltiazem.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Diltiazem.
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Diltiazem.
FluorouracilThe metabolism of Diltiazem can be decreased when combined with Fluorouracil.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Diltiazem.
FluoxetineThe serum concentration of Diltiazem can be increased when it is combined with Fluoxetine.
FlupentixolThe serum concentration of Diltiazem can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Diltiazem can be increased when it is combined with Fluphenazine.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Diltiazem.
FlurazepamThe serum concentration of Diltiazem can be increased when it is combined with Flurazepam.
FlutamideThe metabolism of Flutamide can be decreased when combined with Diltiazem.
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Diltiazem.
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Diltiazem.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Diltiazem.
FluvoxamineThe metabolism of Diltiazem can be decreased when combined with Fluvoxamine.
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Diltiazem.
FosaprepitantThe serum concentration of Diltiazem can be increased when it is combined with Fosaprepitant.
FosinoprilDiltiazem may increase the hypotensive activities of Fosinopril.
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Diltiazem.
FosphenytoinThe metabolism of Diltiazem can be increased when combined with Fosphenytoin.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Diltiazem.
FurazolidoneFurazolidone may increase the hypotensive activities of Diltiazem.
FurosemideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Furosemide.
Fusidic AcidThe serum concentration of Diltiazem can be increased when it is combined with Fusidic Acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Diltiazem.
GalantamineGalantamine may increase the bradycardic activities of Diltiazem.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Diltiazem.
GefitinibThe serum concentration of Diltiazem can be increased when it is combined with Gefitinib.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Diltiazem.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Diltiazem.
GenisteinThe serum concentration of Diltiazem can be increased when it is combined with Genistein.
GlipizideThe metabolism of Glipizide can be decreased when combined with Diltiazem.
GlyburideThe metabolism of Glyburide can be decreased when combined with Diltiazem.
GlyburideThe serum concentration of Diltiazem can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Diltiazem can be increased when it is combined with Glycerol.
GlyphosateThe risk or severity of adverse effects can be increased when Glyphosate is combined with Diltiazem.
Gramicidin DThe serum concentration of Diltiazem can be increased when it is combined with Gramicidin D.
GranisetronThe metabolism of Granisetron can be decreased when combined with Diltiazem.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Diltiazem.
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Diltiazem.
GrepafloxacinThe serum concentration of Diltiazem can be increased when it is combined with Grepafloxacin.
GriseofulvinThe risk or severity of adverse effects can be increased when Griseofulvin is combined with Diltiazem.
GuanabenzDiltiazem may increase the hypotensive activities of Guanabenz.
GuanadrelGuanadrel may increase the hypotensive activities of Diltiazem.
GuanethidineDiltiazem may increase the hypotensive activities of Guanethidine.
GuanfacineDiltiazem may increase the hypotensive activities of Guanfacine.
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Diltiazem.
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Diltiazem.
HaloperidolThe serum concentration of Diltiazem can be increased when it is combined with Haloperidol.
HaloproginThe risk or severity of adverse effects can be increased when Haloprogin is combined with Diltiazem.
HalothaneThe metabolism of Halothane can be decreased when combined with Diltiazem.
HexamethoniumDiltiazem may increase the hypotensive activities of Hexamethonium.
HexetidineThe risk or severity of adverse effects can be increased when Hexetidine is combined with Diltiazem.
HexobarbitalHexobarbital may increase the hypotensive activities of Diltiazem.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Diltiazem.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Diltiazem.
HydracarbazineHydracarbazine may increase the hypotensive activities of Diltiazem.
HydralazineDiltiazem may increase the hypotensive activities of Hydralazine.
HydrochlorothiazideDiltiazem may increase the hypotensive activities of Hydrochlorothiazide.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Diltiazem.
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Diltiazem.
HydrocortisoneThe serum concentration of Diltiazem can be increased when it is combined with Hydrocortisone.
HydroflumethiazideDiltiazem may increase the hypotensive activities of Hydroflumethiazide.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Diltiazem.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Diltiazem.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Diltiazem.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Diltiazem.
IdelalisibThe serum concentration of Diltiazem can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Diltiazem resulting in a loss in efficacy.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Diltiazem.
IloprostIloprost may increase the hypotensive activities of Diltiazem.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Diltiazem.
ImatinibThe metabolism of Diltiazem can be decreased when combined with Imatinib.
ImipramineThe metabolism of Imipramine can be decreased when combined with Diltiazem.
ImipramineThe serum concentration of Diltiazem can be increased when it is combined with Imipramine.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Diltiazem.
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Diltiazem.
IndapamideDiltiazem may increase the hypotensive activities of Indapamide.
IndenololDiltiazem may increase the hypotensive activities of Indenolol.
IndinavirThe metabolism of Indinavir can be decreased when combined with Diltiazem.
IndinavirThe serum concentration of Diltiazem can be decreased when it is combined with Indinavir.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Diltiazem.
IndoraminDiltiazem may increase the hypotensive activities of Indoramin.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Diltiazem.
IproclozideIproclozide may increase the hypotensive activities of Diltiazem.
IproniazidIproniazid may increase the hypotensive activities of Diltiazem.
IrbesartanDiltiazem may increase the hypotensive activities of Irbesartan.
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Diltiazem.
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Diltiazem.
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Diltiazem.
IsoconazoleThe risk or severity of adverse effects can be increased when Isoconazole is combined with Diltiazem.
IsoniazidThe metabolism of Diltiazem can be decreased when combined with Isoniazid.
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Diltiazem is combined with Isosorbide Dinitrate.
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Diltiazem is combined with Isosorbide Mononitrate.
IsoxsuprineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Isoxsuprine.
IsradipineIsradipine may increase the hypotensive activities of Diltiazem.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Diltiazem.
ItraconazoleThe serum concentration of Diltiazem can be increased when it is combined with Itraconazole.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Diltiazem.
IvabradineIvabradine may increase the bradycardic activities of Diltiazem.
IvacaftorThe serum concentration of Diltiazem can be increased when it is combined with Ivacaftor.
IvacaftorThe metabolism of Ivacaftor can be decreased when combined with Diltiazem.
IvermectinThe metabolism of Ivermectin can be decreased when combined with Diltiazem.
IvermectinThe serum concentration of Diltiazem can be increased when it is combined with Ivermectin.
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Diltiazem.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Diltiazem.
KetamineThe metabolism of Ketamine can be decreased when combined with Diltiazem.
KetamineThe serum concentration of Diltiazem can be increased when it is combined with Ketamine.
KetazolamThe metabolism of Ketazolam can be decreased when combined with Diltiazem.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Diltiazem.
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Diltiazem.
KetoconazoleThe serum concentration of Diltiazem can be increased when it is combined with Ketoconazole.
LabetalolDiltiazem may increase the hypotensive activities of Labetalol.
LacidipineDiltiazem may increase the hypotensive activities of Lacidipine.
LacosamideDiltiazem may increase the atrioventricular blocking (AV block) activities of Lacosamide.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Diltiazem.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Diltiazem.
LanreotideDiltiazem may increase the bradycardic activities of Lanreotide.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Diltiazem.
LansoprazoleThe serum concentration of Diltiazem can be increased when it is combined with Lansoprazole.
LapatinibThe metabolism of Lapatinib can be decreased when combined with Diltiazem.
LapatinibThe serum concentration of Diltiazem can be increased when it is combined with Lapatinib.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Diltiazem.
LatanoprostDiltiazem may increase the hypotensive activities of Latanoprost.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Diltiazem.
LeflunomideThe metabolism of Diltiazem can be decreased when combined with Leflunomide.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Diltiazem.
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Diltiazem.
LercanidipineDiltiazem may increase the hypotensive activities of Lercanidipine.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Diltiazem.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Diltiazem.
LevobunololThe risk or severity of adverse effects can be increased when Diltiazem is combined with Levobunolol.
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Diltiazem.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Diltiazem.
LevodopaDiltiazem may increase the orthostatic hypotensive activities of Levodopa.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Diltiazem.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Diltiazem.
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Diltiazem.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Diltiazem.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Diltiazem.
LevothyroxineThe serum concentration of Diltiazem can be decreased when it is combined with Levothyroxine.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Diltiazem.
LidocaineThe serum concentration of Diltiazem can be increased when it is combined with Lidocaine.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Diltiazem.
LiothyronineThe serum concentration of Diltiazem can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Diltiazem can be decreased when it is combined with Liotrix.
LisinoprilDiltiazem may increase the hypotensive activities of Lisinopril.
LisurideThe metabolism of Lisuride can be decreased when combined with Diltiazem.
LofexidineDiltiazem may increase the hypotensive activities of Lofexidine.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Diltiazem.
LoperamideThe metabolism of Loperamide can be decreased when combined with Diltiazem.
LoperamideThe serum concentration of Diltiazem can be increased when it is combined with Loperamide.
LopinavirThe metabolism of Lopinavir can be decreased when combined with Diltiazem.
LopinavirThe serum concentration of Diltiazem can be increased when it is combined with Lopinavir.
LoratadineThe metabolism of Loratadine can be decreased when combined with Diltiazem.
LoratadineThe serum concentration of Diltiazem can be increased when it is combined with Loratadine.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Diltiazem.
LosartanDiltiazem may increase the hypotensive activities of Losartan.
LovastatinThe metabolism of Diltiazem can be decreased when combined with Lovastatin.
LucinactantDiltiazem may increase the bradycardic activities of Lucinactant.
LuliconazoleThe serum concentration of Diltiazem can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Diltiazem can be decreased when it is combined with Lumacaftor.
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Diltiazem.
LurasidoneThe metabolism of Lurasidone can be decreased when combined with Diltiazem.
MacitentanDiltiazem may increase the hypotensive activities of Macitentan.
Magnesium hydroxideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Magnesium hydroxide.
Magnesium oxideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Magnesium oxide.
Magnesium salicylateThe risk or severity of adverse effects can be increased when Diltiazem is combined with Magnesium salicylate.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Diltiazem is combined with Magnesium Sulfate.
ManidipineDiltiazem may increase the hypotensive activities of Manidipine.
MannitolThe risk or severity of adverse effects can be increased when Diltiazem is combined with Mannitol.
MaprotilineThe serum concentration of Diltiazem can be increased when it is combined with Maprotiline.
MaravirocThe metabolism of Maraviroc can be decreased when combined with Diltiazem.
MebanazineMebanazine may increase the hypotensive activities of Diltiazem.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Diltiazem.
MebendazoleThe serum concentration of Diltiazem can be increased when it is combined with Mebendazole.
MecamylamineDiltiazem may increase the hypotensive activities of Mecamylamine.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Diltiazem.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Diltiazem.
MefloquineThe serum concentration of Diltiazem can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Diltiazem can be increased when it is combined with Megestrol acetate.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Diltiazem.
MeprobamateThe serum concentration of Diltiazem can be increased when it is combined with Meprobamate.
MethadoneThe metabolism of Methadone can be decreased when combined with Diltiazem.
MethadoneThe serum concentration of Diltiazem can be increased when it is combined with Methadone.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Diltiazem.
MethazolamideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Methazolamide.
MethohexitalMethohexital may increase the hypotensive activities of Diltiazem.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Diltiazem.
MethotrimeprazineThe metabolism of Diltiazem can be decreased when combined with Methotrimeprazine.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Diltiazem.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Diltiazem.
MethyclothiazideThe risk or severity of adverse effects can be increased when Methyclothiazide is combined with Diltiazem.
MethyldopaDiltiazem may increase the hypotensive activities of Methyldopa.
Methylene blueMethylene blue may increase the hypotensive activities of Diltiazem.
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Diltiazem.
MethylphenobarbitalMethylphenobarbital may increase the hypotensive activities of Diltiazem.
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Diltiazem.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Diltiazem.
MetipranololDiltiazem may increase the hypotensive activities of Metipranolol.
MetolazoneDiltiazem may increase the hypotensive activities of Metolazone.
MetoprololMetoprolol may increase the hypotensive activities of Diltiazem.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Diltiazem.
MevastatinThe risk or severity of adverse effects can be increased when Mevastatin is combined with Diltiazem.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Diltiazem.
MianserinThe metabolism of Mianserin can be decreased when combined with Diltiazem.
MibefradilDiltiazem may increase the hypotensive activities of Mibefradil.
MicafunginThe risk or severity of adverse effects can be increased when Micafungin is combined with Diltiazem.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Diltiazem.
MiconazoleThe serum concentration of Diltiazem can be increased when it is combined with Miconazole.
MidazolamThe metabolism of Midazolam can be decreased when combined with Diltiazem.
MidazolamThe serum concentration of Diltiazem can be decreased when it is combined with Midazolam.
MifepristoneThe metabolism of Mifepristone can be decreased when combined with Diltiazem.
MiltefosineThe risk or severity of adverse effects can be increased when Miltefosine is combined with Diltiazem.
MinaprineMinaprine may increase the hypotensive activities of Diltiazem.
MinoxidilDiltiazem may increase the hypotensive activities of Minoxidil.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Diltiazem.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Diltiazem.
MitomycinThe serum concentration of Diltiazem can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Diltiazem can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Diltiazem can be decreased when it is combined with Mitoxantrone.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Diltiazem.
MivacuriumDiltiazem may increase the neuromuscular blocking activities of Mivacurium.
MoclobemideMoclobemide may increase the hypotensive activities of Diltiazem.
ModafinilThe serum concentration of Diltiazem can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Diltiazem.
MoexiprilDiltiazem may increase the hypotensive activities of Moexipril.
MolsidomineMolsidomine may increase the hypotensive activities of Diltiazem.
MonensinThe risk or severity of adverse effects can be increased when Monensin is combined with Diltiazem.
MontelukastThe metabolism of Montelukast can be decreased when combined with Diltiazem.
MorphineThe metabolism of Morphine can be decreased when combined with Diltiazem.
MorphineThe serum concentration of Diltiazem can be increased when it is combined with Morphine.
MoxonidineDiltiazem may increase the hypotensive activities of Moxonidine.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Diltiazem.
MyxothiazolThe risk or severity of adverse effects can be increased when Myxothiazol is combined with Diltiazem.
NadololDiltiazem may increase the hypotensive activities of Nadolol.
NafcillinThe serum concentration of Diltiazem can be decreased when it is combined with Nafcillin.
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Diltiazem.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Diltiazem.
NaloxoneThe metabolism of Naloxone can be decreased when combined with Diltiazem.
NaltrexoneThe serum concentration of Diltiazem can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Diltiazem can be increased when it is combined with Naringenin.
NatamycinThe risk or severity of adverse effects can be increased when Natamycin is combined with Diltiazem.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Diltiazem.
NebivololDiltiazem may increase the hypotensive activities of Nebivolol.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Diltiazem.
NefazodoneThe serum concentration of Diltiazem can be decreased when it is combined with Nefazodone.
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Diltiazem.
NelfinavirThe serum concentration of Diltiazem can be decreased when it is combined with Nelfinavir.
NeostigmineThe serum concentration of Diltiazem can be increased when it is combined with Neostigmine.
NesiritideThe risk or severity of adverse effects can be increased when Diltiazem is combined with Nesiritide.
NetupitantThe serum concentration of Diltiazem can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Diltiazem can be decreased when combined with Nevirapine.
NialamideNialamide may increase the hypotensive activities of Diltiazem.
NicardipineDiltiazem may increase the hypotensive activities of Nicardipine.
NicorandilNicorandil may increase the hypotensive activities of Diltiazem.
NicotineThe metabolism of Nicotine can be decreased when combined with Diltiazem.
NifedipineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Nifedipine.
NiguldipineDiltiazem may increase the hypotensive activities of Niguldipine.
NilotinibThe metabolism of Nilotinib can be decreased when combined with Diltiazem.
NilvadipineDiltiazem may increase the hypotensive activities of Nilvadipine.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Diltiazem.
NimodipineNimodipine may increase the hypotensive activities of Diltiazem.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Diltiazem.
NisoldipineDiltiazem may increase the hypotensive activities of Nisoldipine.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Diltiazem.
NitrazepamThe serum concentration of Diltiazem can be increased when it is combined with Nitrazepam.
NitrendipineDiltiazem may increase the hypotensive activities of Nitrendipine.
NitroglycerinThe risk or severity of adverse effects can be increased when Diltiazem is combined with Nitroglycerin.
NitroprussideDiltiazem may increase the hypotensive activities of Nitroprusside.
NitroxolineThe risk or severity of adverse effects can be increased when Nitroxoline is combined with Diltiazem.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Diltiazem.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Diltiazem.
NorethisteroneThe serum concentration of Diltiazem can be decreased when it is combined with Norethisterone.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Diltiazem.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Diltiazem.
NystatinThe risk or severity of adverse effects can be increased when Nystatin is combined with Diltiazem.
ObinutuzumabDiltiazem may increase the hypotensive activities of Obinutuzumab.
OctamoxinOctamoxin may increase the hypotensive activities of Diltiazem.
OctreotideOctreotide may increase the bradycardic activities of Diltiazem.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Diltiazem.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Diltiazem.
OlaparibThe metabolism of Diltiazem can be decreased when combined with Olaparib.
OlmesartanOlmesartan may increase the hypotensive activities of Diltiazem.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Diltiazem.
OmapatrilatDiltiazem may increase the hypotensive activities of Omapatrilat.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Diltiazem.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Diltiazem.
OmeprazoleThe serum concentration of Diltiazem can be increased when it is combined with Omeprazole.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Diltiazem.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Diltiazem.
OsimertinibThe serum concentration of Diltiazem can be increased when it is combined with Osimertinib.
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Diltiazem.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Diltiazem.
OxiconazoleThe risk or severity of adverse effects can be increased when Oxiconazole is combined with Diltiazem.
OxprenololDiltiazem may increase the hypotensive activities of Oxprenolol.
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Diltiazem.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Diltiazem.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Diltiazem.
P-NitrophenolThe serum concentration of Diltiazem can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Diltiazem.
PaclitaxelThe serum concentration of Diltiazem can be increased when it is combined with Paclitaxel.
pafuramidineThe risk or severity of adverse effects can be increased when pafuramidine is combined with Diltiazem.
PalbociclibThe serum concentration of Diltiazem can be increased when it is combined with Palbociclib.
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Diltiazem.
Palmitic AcidThe serum concentration of Diltiazem can be increased when it is combined with Palmitic Acid.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Diltiazem.
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Diltiazem.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Diltiazem.
PantoprazoleThe serum concentration of Diltiazem can be increased when it is combined with Pantoprazole.
PapaverineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Papaverine.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Diltiazem.
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Diltiazem.
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Diltiazem.
PargylineDiltiazem may increase the hypotensive activities of Pargyline.
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Diltiazem.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Diltiazem.
ParoxetineThe serum concentration of Diltiazem can be increased when it is combined with Paroxetine.
PasireotideDiltiazem may increase the bradycardic activities of Pasireotide.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Diltiazem.
Peginterferon alfa-2bThe serum concentration of Diltiazem can be decreased when it is combined with Peginterferon alfa-2b.
PenbutololDiltiazem may increase the hypotensive activities of Penbutolol.
PentamidineThe risk or severity of adverse effects can be increased when Pentamidine is combined with Diltiazem.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Diltiazem.
PentobarbitalPentobarbital may increase the hypotensive activities of Diltiazem.
PentoliniumDiltiazem may increase the hypotensive activities of Pentolinium.
PentoxifyllinePentoxifylline may increase the hypotensive activities of Diltiazem.
PerampanelThe metabolism of Perampanel can be decreased when combined with Diltiazem.
PergolideThe metabolism of Pergolide can be decreased when combined with Diltiazem.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Diltiazem.
PerindoprilDiltiazem may increase the hypotensive activities of Perindopril.
PermethrinThe metabolism of Permethrin can be decreased when combined with Diltiazem.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Diltiazem.
PethidineThe metabolism of Pethidine can be decreased when combined with Diltiazem.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Diltiazem.
PhenelzinePhenelzine may increase the hypotensive activities of Diltiazem.
PheniprazinePheniprazine may increase the hypotensive activities of Diltiazem.
PhenobarbitalPhenobarbital may increase the hypotensive activities of Diltiazem.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Diltiazem.
PhenoxybenzamineDiltiazem may increase the hypotensive activities of Phenoxybenzamine.
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Diltiazem.
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Diltiazem.
PhentolamineDiltiazem may increase the hypotensive activities of Phentolamine.
PhenytoinThe metabolism of Diltiazem can be increased when combined with Phenytoin.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Diltiazem.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Diltiazem.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Diltiazem.
PinacidilDiltiazem may increase the hypotensive activities of Pinacidil.
PindololDiltiazem may increase the hypotensive activities of Pindolol.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Diltiazem.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Diltiazem.
PirlindolePirlindole may increase the hypotensive activities of Diltiazem.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Diltiazem.
PivhydrazinePivhydrazine may increase the hypotensive activities of Diltiazem.
Platelet Activating FactorThe serum concentration of Diltiazem can be decreased when it is combined with Platelet Activating Factor.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Diltiazem.
PolythiazideDiltiazem may increase the hypotensive activities of Polythiazide.
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Diltiazem.
PonatinibThe metabolism of Ponatinib can be decreased when combined with Diltiazem.
PonatinibThe serum concentration of Diltiazem can be increased when it is combined with Ponatinib.
Poractant alfaDiltiazem may increase the bradycardic activities of Poractant alfa.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Diltiazem.
PosaconazoleThe serum concentration of Diltiazem can be increased when it is combined with Posaconazole.
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Diltiazem.
PravastatinThe metabolism of Pravastatin can be decreased when combined with Diltiazem.
PravastatinThe serum concentration of Diltiazem can be increased when it is combined with Pravastatin.
PrazepamThe metabolism of Prazepam can be decreased when combined with Diltiazem.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Diltiazem.
PrazosinDiltiazem may increase the hypotensive activities of Prazosin.
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Diltiazem.
PrednisoneThe metabolism of Prednisone can be decreased when combined with Diltiazem.
PrednisoneThe serum concentration of Diltiazem can be increased when it is combined with Prednisone.
PrimaquineThe metabolism of Primaquine can be decreased when combined with Diltiazem.
PrimidonePrimidone may increase the hypotensive activities of Diltiazem.
ProbenecidThe serum concentration of Diltiazem can be increased when it is combined with Probenecid.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Diltiazem.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Diltiazem.
ProgesteroneThe serum concentration of Diltiazem can be decreased when it is combined with Progesterone.
ProguanilThe metabolism of Proguanil can be decreased when combined with Diltiazem.
PromazineThe metabolism of Promazine can be decreased when combined with Diltiazem.
PromethazineThe serum concentration of Diltiazem can be increased when it is combined with Promethazine.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Diltiazem.
PropofolThe metabolism of Propofol can be decreased when combined with Diltiazem.
PropranololDiltiazem may increase the hypotensive activities of Propranolol.
ProtriptylineThe serum concentration of Diltiazem can be increased when it is combined with Protriptyline.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Diltiazem.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Diltiazem.
PyrimethamineThe metabolism of Diltiazem can be decreased when combined with Pyrimethamine.
QuazepamThe metabolism of Quazepam can be decreased when combined with Diltiazem.
QuercetinThe serum concentration of Diltiazem can be increased when it is combined with Quercetin.
QuetiapineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Quetiapine.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Diltiazem.
QuinacrineThe serum concentration of Diltiazem can be increased when it is combined with Quinacrine.
QuinaprilDiltiazem may increase the hypotensive activities of Quinapril.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Diltiazem.
QuinineQuinine may increase the hypotensive activities of Diltiazem.
QuinineThe metabolism of Quinine can be decreased when combined with Diltiazem.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Diltiazem.
RadicicolThe risk or severity of adverse effects can be increased when Radicicol is combined with Diltiazem.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Diltiazem.
RamelteonThe metabolism of Ramelteon can be decreased when combined with Diltiazem.
RamiprilRamipril may increase the hypotensive activities of Diltiazem.
RanitidineThe serum concentration of Diltiazem can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Diltiazem.
RapacuroniumDiltiazem may increase the neuromuscular blocking activities of Rapacuronium.
RasagilineRasagiline may increase the hypotensive activities of Diltiazem.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Diltiazem.
ReboxetineThe serum concentration of Diltiazem can be increased when it is combined with Reboxetine.
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Diltiazem.
RegorafenibThe serum concentration of Diltiazem can be increased when it is combined with Regorafenib.
RemikirenRemikiren may increase the hypotensive activities of Diltiazem.
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Diltiazem.
RescinnamineDiltiazem may increase the hypotensive activities of Rescinnamine.
ReserpineReserpine may increase the hypotensive activities of Diltiazem.
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Diltiazem.
RifabutinThe metabolism of Diltiazem can be increased when combined with Rifabutin.
RifampicinThe serum concentration of Diltiazem can be decreased when it is combined with Rifampicin.
RifampicinThe metabolism of Rifampicin can be decreased when combined with Diltiazem.
RifapentineThe metabolism of Diltiazem can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Diltiazem.
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Diltiazem.
RilpivirineThe serum concentration of Diltiazem can be increased when it is combined with Rilpivirine.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Diltiazem.
RiociguatDiltiazem may increase the hypotensive activities of Riociguat.
RisperidoneDiltiazem may increase the hypotensive activities of Risperidone.
RitonavirThe metabolism of Ritonavir can be decreased when combined with Diltiazem.
RitonavirThe serum concentration of Diltiazem can be decreased when it is combined with Ritonavir.
RituximabDiltiazem may increase the hypotensive activities of Rituximab.
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Diltiazem.
RivastigmineDiltiazem may increase the bradycardic activities of Rivastigmine.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Diltiazem.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Diltiazem.
RolapitantThe serum concentration of Diltiazem can be increased when it is combined with Rolapitant.
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Diltiazem.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Diltiazem.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Diltiazem.
RosiglitazoneThe metabolism of Diltiazem can be decreased when combined with Rosiglitazone.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Diltiazem.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Diltiazem.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Diltiazem.
RuxolitinibRuxolitinib may increase the bradycardic activities of Diltiazem.
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Diltiazem.
SafrazineSafrazine may increase the hypotensive activities of Diltiazem.
Salicylhydroxamic AcidThe risk or severity of adverse effects can be increased when Salicylhydroxamic Acid is combined with Diltiazem.
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Diltiazem.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Diltiazem.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Diltiazem.
SaprisartanDiltiazem may increase the hypotensive activities of Saprisartan.
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Diltiazem.
SaquinavirThe serum concentration of Diltiazem can be decreased when it is combined with Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Diltiazem.
ScopolamineThe serum concentration of Diltiazem can be increased when it is combined with Scopolamine.
SecobarbitalSecobarbital may increase the hypotensive activities of Diltiazem.
SelegilineSelegiline may increase the hypotensive activities of Diltiazem.
SelegilineThe metabolism of Selegiline can be decreased when combined with Diltiazem.
SelexipagDiltiazem may increase the hypotensive activities of Selexipag.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Diltiazem.
SertaconazoleThe risk or severity of adverse effects can be increased when Sertaconazole is combined with Diltiazem.
SertindoleThe metabolism of Sertindole can be decreased when combined with Diltiazem.
SertralineThe metabolism of Sertraline can be decreased when combined with Diltiazem.
SertralineThe serum concentration of Diltiazem can be increased when it is combined with Sertraline.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Diltiazem.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Diltiazem.
SildenafilSildenafil may increase the antihypertensive activities of Diltiazem.
SildenafilThe metabolism of Sildenafil can be decreased when combined with Diltiazem.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Diltiazem.
SilodosinSilodosin may increase the hypotensive activities of Diltiazem.
SiltuximabThe serum concentration of Diltiazem can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Diltiazem can be increased when it is combined with Simeprevir.
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Diltiazem.
SimvastatinThe serum concentration of Diltiazem can be increased when it is combined with Simvastatin.
SinefunginThe risk or severity of adverse effects can be increased when Sinefungin is combined with Diltiazem.
SirolimusThe metabolism of Sirolimus can be decreased when combined with Diltiazem.
SirolimusThe serum concentration of Diltiazem can be decreased when it is combined with Sirolimus.
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Diltiazem.
SitaxentanDiltiazem may increase the hypotensive activities of Sitaxentan.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Diltiazem.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Diltiazem.
SonidegibThe metabolism of Sonidegib can be decreased when combined with Diltiazem.
SorafenibThe metabolism of Sorafenib can be decreased when combined with Diltiazem.
SorafenibThe serum concentration of Diltiazem can be increased when it is combined with Sorafenib.
SotalolThe risk or severity of adverse effects can be increased when Diltiazem is combined with Sotalol.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Diltiazem.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Diltiazem.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Diltiazem.
SpiraprilDiltiazem may increase the hypotensive activities of Spirapril.
SpironolactoneThe risk or severity of adverse effects can be increased when Diltiazem is combined with Spironolactone.
St. John's WortThe serum concentration of Diltiazem can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Diltiazem can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Diltiazem can be increased when it is combined with Stiripentol.
StreptozocinThe serum concentration of Diltiazem can be decreased when it is combined with Streptozocin.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Diltiazem.
SufentanilSufentanil may increase the bradycardic activities of Diltiazem.
SulconazoleThe risk or severity of adverse effects can be increased when Sulconazole is combined with Diltiazem.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Diltiazem.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Diltiazem.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Diltiazem.
SulfinpyrazoneThe serum concentration of Diltiazem can be increased when it is combined with Sulfinpyrazone.
SulfisoxazoleThe metabolism of Diltiazem can be decreased when combined with Sulfisoxazole.
SumatriptanThe serum concentration of Diltiazem can be increased when it is combined with Sumatriptan.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Diltiazem.
SunitinibThe serum concentration of Diltiazem can be increased when it is combined with Sunitinib.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Diltiazem.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Diltiazem.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Diltiazem.
TacrineThe serum concentration of Diltiazem can be increased when it is combined with Tacrine.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Diltiazem.
TacrolimusThe serum concentration of Diltiazem can be decreased when it is combined with Tacrolimus.
TadalafilTadalafil may increase the antihypertensive activities of Diltiazem.
TadalafilThe metabolism of Tadalafil can be decreased when combined with Diltiazem.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Diltiazem.
TamoxifenThe serum concentration of Diltiazem can be decreased when it is combined with Tamoxifen.
TamsulosinTamsulosin may increase the hypotensive activities of Diltiazem.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Diltiazem.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Diltiazem.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Diltiazem.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Diltiazem.
TavaboroleThe risk or severity of adverse effects can be increased when Tavaborole is combined with Diltiazem.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Diltiazem.
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Diltiazem.
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Diltiazem.
TelmisartanDiltiazem may increase the hypotensive activities of Telmisartan.
TemazepamThe metabolism of Temazepam can be decreased when combined with Diltiazem.
TemocaprilDiltiazem may increase the hypotensive activities of Temocapril.
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Diltiazem.
TemsirolimusThe serum concentration of Diltiazem can be increased when it is combined with Temsirolimus.
TeniposideThe metabolism of Teniposide can be decreased when combined with Diltiazem.
TerazosinTerazosin may increase the hypotensive activities of Diltiazem.
TerazosinThe risk or severity of adverse effects can be increased when Diltiazem is combined with Terazosin.
TerbinafineThe risk or severity of adverse effects can be increased when Terbinafine is combined with Diltiazem.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Diltiazem.
TerconazoleThe risk or severity of adverse effects can be increased when Terconazole is combined with Diltiazem.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Diltiazem.
TerfenadineThe serum concentration of Diltiazem can be increased when it is combined with Terfenadine.
TeriflunomideThe metabolism of Diltiazem can be decreased when combined with Teriflunomide.
TerlipressinDiltiazem may increase the hypotensive activities of Terlipressin.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Diltiazem.
TesmilifeneThe serum concentration of Diltiazem can be decreased when it is combined with Tesmilifene.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Diltiazem.
TestosteroneThe serum concentration of Diltiazem can be increased when it is combined with Testosterone.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Diltiazem.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Diltiazem.
ThiamylalThiamylal may increase the hypotensive activities of Diltiazem.
ThiopentalThiopental may increase the hypotensive activities of Diltiazem.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Diltiazem.
ThioridazineThe metabolism of Diltiazem can be decreased when combined with Thioridazine.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Diltiazem.
ThymolThe risk or severity of adverse effects can be increased when Thymol is combined with Diltiazem.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Diltiazem.
TiboloneDiltiazem may increase the hypotensive activities of Tibolone.
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Diltiazem.
TicagrelorThe serum concentration of Diltiazem can be increased when it is combined with Ticagrelor.
TiclopidineThe metabolism of Diltiazem can be decreased when combined with Ticlopidine.
TicrynafenDiltiazem may increase the hypotensive activities of Ticrynafen.
TimololDiltiazem may increase the hypotensive activities of Timolol.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Diltiazem.
TioconazoleThe risk or severity of adverse effects can be increased when Tioconazole is combined with Diltiazem.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Diltiazem.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Diltiazem.
TizanidineThe risk or severity of adverse effects can be increased when Diltiazem is combined with Tizanidine.
TocilizumabThe serum concentration of Diltiazem can be decreased when it is combined with Tocilizumab.
TofacitinibTofacitinib may increase the bradycardic activities of Diltiazem.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Diltiazem.
TolazolineDiltiazem may increase the hypotensive activities of Tolazoline.
TolbutamideThe metabolism of Diltiazem can be decreased when combined with Tolbutamide.
TolnaftateThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Diltiazem.
ToloxatoneToloxatone may increase the hypotensive activities of Diltiazem.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Diltiazem.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Diltiazem.
TopiramateThe metabolism of Diltiazem can be decreased when combined with Topiramate.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Diltiazem.
TorasemideTorasemide may increase the hypotensive activities of Diltiazem.
ToremifeneThe metabolism of Toremifene can be decreased when combined with Diltiazem.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Diltiazem.
TramadolThe metabolism of Tramadol can be decreased when combined with Diltiazem.
TrandolaprilDiltiazem may increase the hypotensive activities of Trandolapril.
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypotensive activities of Diltiazem.
TranylcypromineTranylcypromine may increase the hypotensive activities of Diltiazem.
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Diltiazem.
TravoprostTravoprost may increase the hypotensive activities of Diltiazem.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Diltiazem.
TrazodoneThe serum concentration of Diltiazem can be decreased when it is combined with Trazodone.
TreprostinilDiltiazem may increase the hypotensive activities of Treprostinil.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Diltiazem.
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Diltiazem.
TriamtereneThe risk or severity of adverse effects can be increased when Diltiazem is combined with Triamterene.
TriazolamThe metabolism of Triazolam can be decreased when combined with Diltiazem.
TrichlormethiazideDiltiazem may increase the hypotensive activities of Trichlormethiazide.
TrifluoperazineThe serum concentration of Diltiazem can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Diltiazem can be increased when it is combined with Triflupromazine.
TrimazosinDiltiazem may increase the hypotensive activities of Trimazosin.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Diltiazem.
TrimethaphanDiltiazem may increase the hypotensive activities of Trimethaphan.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Diltiazem.
TrimethoprimThe serum concentration of Diltiazem can be decreased when it is combined with Trimethoprim.
TrimetrexateThe risk or severity of adverse effects can be increased when Trimetrexate is combined with Diltiazem.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Diltiazem.
TrimipramineThe serum concentration of Diltiazem can be increased when it is combined with Trimipramine.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Diltiazem.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Diltiazem.
TroleandomycinThe serum concentration of Diltiazem can be increased when it is combined with Troleandomycin.
UdenafilUdenafil may increase the antihypertensive activities of Diltiazem.
UdenafilThe metabolism of Udenafil can be decreased when combined with Diltiazem.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Diltiazem.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Diltiazem.
UnoprostoneDiltiazem may increase the hypotensive activities of Unoprostone.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Diltiazem.
Valproic AcidThe metabolism of Diltiazem can be decreased when combined with Valproic Acid.
ValsartanValsartan may increase the hypotensive activities of Diltiazem.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Diltiazem.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Diltiazem.
VardenafilVardenafil may increase the antihypertensive activities of Diltiazem.
VardenafilThe metabolism of Vardenafil can be decreased when combined with Diltiazem.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Diltiazem.
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Diltiazem.
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Diltiazem.
VerapamilThe risk or severity of adverse effects can be increased when Diltiazem is combined with Verapamil.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Diltiazem.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Diltiazem.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Diltiazem.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Diltiazem.
VinblastineThe serum concentration of Diltiazem can be decreased when it is combined with Vinblastine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Diltiazem.
VincristineThe serum concentration of Diltiazem can be decreased when it is combined with Vincristine.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Diltiazem.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Diltiazem.
VinorelbineThe serum concentration of Diltiazem can be increased when it is combined with Vinorelbine.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Diltiazem.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Diltiazem.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Diltiazem.
WarfarinThe metabolism of Warfarin can be decreased when combined with Diltiazem.
XylometazolineDiltiazem may increase the hypotensive activities of Xylometazoline.
YohimbineYohimbine may decrease the antihypertensive activities of Diltiazem.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Diltiazem.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Diltiazem.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Diltiazem.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Diltiazem.
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Diltiazem.
ZileutonThe metabolism of Zileuton can be decreased when combined with Diltiazem.
ZimelidineThe serum concentration of Diltiazem can be increased when it is combined with Zimelidine.
ZiprasidoneThe metabolism of Diltiazem can be decreased when combined with Ziprasidone.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Diltiazem.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Diltiazem.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Diltiazem.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Diltiazem.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Diltiazem.
Food Interactions
  • Avoid natural licorice.
  • Take this medication 30 minutes before meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated calcium channel activity
Specific Function:
This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca(2+) channel may function only as a multiple subunit complex.
Gene Name:
CACNG1
Uniprot ID:
Q06432
Molecular Weight:
25028.105 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Budriesi R, Ioan P, Carosati E, Cruciani G, Zhorov BS, Chiarini A: Ligands of diltiazem binding site: an overview of some chemotypes. Mini Rev Med Chem. 2009 Oct;9(12):1379-88. [PubMed:19929811 ]
  4. Romero M, Sanchez I, Pujol MD: New advances in the field of calcium channel antagonists: cardiovascular effects and structure-activity relationships. Curr Med Chem Cardiovasc Hematol Agents. 2003 Jun;1(2):113-41. [PubMed:15320693 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Williams JA, Ring BJ, Cantrell VE, Jones DR, Eckstein J, Ruterbories K, Hamman MA, Hall SD, Wrighton SA: Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab Dispos. 2002 Aug;30(8):883-91. [PubMed:12124305 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Kosuge K, Jun Y, Watanabe H, Kimura M, Nishimoto M, Ishizaki T, Ohashi K: Effects of CYP3A4 inhibition by diltiazem on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status. Drug Metab Dispos. 2001 Oct;29(10):1284-9. [PubMed:11560871 ]
  2. McGinnity DF, Parker AJ, Soars M, Riley RJ: Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s. Drug Metab Dispos. 2000 Nov;28(11):1327-34. [PubMed:11038161 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. [PubMed:11602674 ]
  2. Takara K, Sakaeda T, Tanigawara Y, Nishiguchi K, Ohmoto N, Horinouchi M, Komada F, Ohnishi N, Yokoyama T, Okumura K: Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression. Eur J Pharm Sci. 2002 Aug;16(3):159-65. [PubMed:12128170 ]
  3. Saeki T, Ueda K, Tanigawara Y, Hori R, Komano T: P-glycoprotein-mediated transcellular transport of MDR-reversing agents. FEBS Lett. 1993 Jun 7;324(1):99-102. [PubMed:8099333 ]
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Drug created on June 13, 2005 07:24 / Updated on September 26, 2016 02:13