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Identification
NameDiltiazem
Accession NumberDB00343  (APRD00473)
TypeSmall Molecule
GroupsApproved
Description

A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. It is also teratogenic. [PubChem]

Structure
Thumb
Synonyms
(+)-cis-5-[2-(dimethylamino)Ethyl]-2,3-dihydro-3-hydroxy-2-(P-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester
(2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
(2S,3S)-5-(2-(dimethylamino)Ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
Diltiazem
Diltiazemum
External Identifiers Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Diltiazem CDcapsule (extended release)240 mgoralActavis Pharma Company2011-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Diltiazem CDcapsule (extended release)180 mgoralActavis Pharma Company2011-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Diltiazem CDcapsule (extended release)120 mgoralActavis Pharma Company2011-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Diltiazem CDcapsule (extended release)300 mgoralActavis Pharma Company2011-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Diltiazem Tcapsule (extended release)120 mgoralActavis Pharma Company2011-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Diltiazem Tcapsule (extended release)360 mgoralActavis Pharma Company2011-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Diltiazem Tcapsule (extended release)300 mgoralActavis Pharma Company2011-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Diltiazem Tcapsule (extended release)240 mgoralActavis Pharma Company2011-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Diltiazem Tcapsule (extended release)180 mgoralActavis Pharma Company2011-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Alti-diltiazem Tab 30mgtablet30 mgoralAltimed Pharma Inc.1990-12-312005-05-27Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Alti-diltiazem Tab 60mgtablet60 mgoralAltimed Pharma Inc.1990-12-312005-05-27Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ava-diltiazemtablet60 mgoralAvanstra Inc2011-10-112014-08-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ava-diltiazemtablet30 mgoralAvanstra Inc2011-10-112014-08-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cardizemtablet, coated60 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizemtablet, coated30 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizemtablet30 mgoralBiovail Pharmaceuticals Canada Division Of Biovail Corporation1995-12-312007-03-27Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cardizemtablet60 mgoralBiovail Pharmaceuticals Canada Division Of Biovail Corporation1995-12-312008-07-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cardizemcapsule240 mg/1oralCardinal Health2001-04-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizemcapsule180 mg/1oralCardinal Health2001-04-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizemtablet, coated120 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem CDcapsule (extended release)180 mgoralValeant Canada Lp Valeant Canada S.E.C.1995-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cardizem CDcapsule (extended release)240 mgoralValeant Canada Lp Valeant Canada S.E.C.1995-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cardizem CDcapsule, coated, extended release360 mg/1oralValeant Pharmaceuticals North America LLC2001-04-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem CDcapsule (extended release)120 mgoralValeant Canada Lp Valeant Canada S.E.C.1995-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cardizem CDcapsule, coated, extended release300 mg/1oralValeant Pharmaceuticals North America LLC2001-04-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem CDcapsule (extended release)300 mgoralValeant Canada Lp Valeant Canada S.E.C.1995-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cardizem CDcapsule, coated, extended release240 mg/1oralValeant Pharmaceuticals North America LLC2001-04-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem CDcapsule, coated, extended release180 mg/1oralValeant Pharmaceuticals North America LLC2001-04-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem CDcapsule240 mg/1oralPhysicians Total Care, Inc.1993-06-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem CDcapsule, coated, extended release120 mg/1oralValeant Pharmaceuticals North America LLC2001-04-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem CDcapsule180 mg/1oralCardinal Health2001-04-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem Injectableliquid5 mgintravenousCrystaal, Division Of Biovail Corporation1995-12-312002-11-15Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cardizem Injectable Liq 5mg/mlliquid5 mgintravenousLabs Nordic Laboratories Inc. Subsidary Of M.M.D.C.1993-12-311996-09-09Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cardizem LAtablet, extended release300 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem LAtablet, extended release120 mg/1oralAbb Vie Inc.2010-12-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem LAtablet, extended release120 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem LAtablet, extended release420 mg/1oralAbb Vie Inc.2010-12-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem LAtablet, extended release360 mg/1oralAbb Vie Inc.2010-12-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem LAtablet, extended release300 mg/1oralAbb Vie Inc.2010-12-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem LAtablet, extended release240 mg/1oralAbb Vie Inc.2010-12-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem LAtablet, extended release420 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem LAtablet, extended release240 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem LAtablet, extended release360 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem LAtablet, extended release180 mg/1oralAbb Vie Inc.2010-12-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem LAtablet, extended release180 mg/1oralValeant Pharmaceuticals North America LLC2010-12-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cardizem SR 120mgcapsule (sustained-release)120 mgoralBiovail Pharmaceuticals Canada Division Of Biovail Corporation1994-12-312004-11-11Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cardizem SR 60mgcapsule (sustained-release)60 mgoralBiovail Pharmaceuticals Canada Division Of Biovail Corporation1995-12-312004-11-11Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cardizem SR 90mgcapsule (sustained-release)90 mgoralBiovail Pharmaceuticals Canada Division Of Biovail Corporation1995-12-312004-11-11Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dilacor XRcapsule, extended release180 mg/1oralActavis Pharma, Inc.1992-05-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Dilacor XRcapsule, extended release120 mg/1oralActavis Pharma, Inc.1992-05-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Dilacor XRcapsule, extended release240 mg/1oralActavis Pharma, Inc.1992-05-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem - CDcapsule (controlled-delivery)240 mgoralPro Doc Limitee1998-06-02Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem - CDcapsule (controlled-delivery)300 mgoralPro Doc Limitee1998-10-09Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem - CDcapsule (controlled-delivery)180 mgoralPro Doc Limitee1998-06-02Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem - CDcapsule (controlled-delivery)120 mgoralPro Doc Limitee1998-06-01Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem CDcapsule (extended release)180 mgoralSivem Pharmaceuticals Ulc2015-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem CDcapsule (extended release)120 mgoralSivem Pharmaceuticals Ulc2015-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem CDcapsule (controlled-delivery)300 mgoralSanis Health Inc2013-02-13Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem CDcapsule (controlled-delivery)240 mgoralSanis Health Inc2013-02-13Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem CDcapsule (controlled-delivery)180 mgoralSanis Health Inc2013-02-13Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem CDcapsule (controlled-delivery)120 mgoralSanis Health Inc2013-02-13Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem CDcapsule (extended release)300 mgoralSivem Pharmaceuticals Ulc2015-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem CDcapsule (extended release)240 mgoralSivem Pharmaceuticals Ulc2015-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem HClinjection, solution1 mg/mLintravenousCantrell Drug Company2011-09-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem HClinjection, solution.83 mg/mLintravenousCantrell Drug Company2013-10-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem HCl CDcapsule, coated, extended release360 mg/1oralOceanside Pharmaceuticals2012-07-182018-05-31Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release360 mg/1oralOceanside Pharmaceuticals2014-02-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralbryant ranch prepack2009-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralPhysicians Total Care, Inc.2005-01-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release180 mg/1oralOceanside Pharmaceuticals2014-02-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralCarilion Materials Management2009-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralPhysicians Total Care, Inc.2004-02-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralCarilion Materials Management2009-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralPhysicians Total Care, Inc.2000-05-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralCarilion Materials Management2009-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralPhysicians Total Care, Inc.2000-05-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralCarilion Materials Management2009-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralPhysicians Total Care, Inc.2000-11-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralCarilion Materials Management2009-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release300 mg/1oralOceanside Pharmaceuticals2014-02-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release420 mg/1oralOceanside Pharmaceuticals2014-02-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralbryant ranch prepack2009-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release240 mg/1oralOceanside Pharmaceuticals2014-02-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, extended release120 mg/1oralOceanside Pharmaceuticals2014-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, extended release420 mg/1oralOceanside Pharmaceuticals2014-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, extended release360 mg/1oralOceanside Pharmaceuticals2014-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, extended release300 mg/1oralOceanside Pharmaceuticals2014-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, extended release240 mg/1oralOceanside Pharmaceuticals2014-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, extended release180 mg/1oralOceanside Pharmaceuticals2014-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Injectionsolution5 mgintravenousMylan Pharmaceuticals UlcNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem Hydrochloride Injectionsolution5 mgintravenousSandoz Canada Incorporated2002-01-09Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem Hydrochloride Injectionsolution5 mgintravenousTeva Canada Limited1997-04-10Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem Tablets 30mgtablet30 mgoralPrempharm Inc1996-12-302005-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem Tablets 60mgtablet60 mgoralPrempharm Inc1997-04-302005-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem TZcapsule (extended release)360 mgoralPro Doc Limitee2009-06-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem TZcapsule (extended release)300 mgoralPro Doc Limitee2009-06-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem TZcapsule (extended release)240 mgoralPro Doc Limitee2009-06-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem TZcapsule (extended release)180 mgoralPro Doc Limitee2009-06-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem TZcapsule (extended release)120 mgoralPro Doc Limitee2009-06-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem-30 Tab 30mgtablet30 mgoralPro Doc Limitee1989-12-312012-07-23Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diltiazem-60 Tab 60mgtablet60 mgoralPro Doc Limitee1989-12-312012-07-23Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Gen-diltiazem - Tab 30mgtablet30 mgoralGenpharm Ulc1995-12-312009-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Gen-diltiazem - Tab 60mgtablet60 mgoralGenpharm Ulc1995-12-312009-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Gen-diltiazem CDcapsule (extended release)300 mgoralGenpharm Ulc2004-08-172009-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Gen-diltiazem CDcapsule (extended release)240 mgoralGenpharm Ulc2004-08-172009-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Gen-diltiazem CDcapsule (extended release)180 mgoralGenpharm Ulc2004-08-172009-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Gen-diltiazem CDcapsule (extended release)120 mgoralGenpharm Ulc2004-08-172009-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Gen-diltiazem SR 120mgcapsule (sustained-release)120 mgoralGenpharm Ulc1997-07-182009-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Gen-diltiazem SR 60mgcapsule (sustained-release)60 mgoralGenpharm Ulc1997-07-182009-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Gen-diltiazem SR 90mgcapsule (sustained-release)90 mgoralGenpharm Ulc1997-07-182009-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Med Diltiazem - Tab 30mgtablet30 mgoralMedican Pharma Incorporated1997-01-232011-03-29Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Med Diltiazem - Tab 60mgtablet60 mgoralMedican Pharma Incorporated1997-03-122011-03-29Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Novo-diltazem SR Capsulescapsule (sustained-release)90 mgoralNovopharm Limited1997-03-192005-08-10Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Novo-diltazem SR Capsulescapsule (sustained-release)60 mgoralNovopharm Limited1997-03-192005-08-10Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Novo-diltazem SR Capsulescapsule (sustained-release)120 mgoralNovopharm Limited1997-03-192005-08-10Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-diltiaz Tab 30mgtablet30 mgoralNu Pharm Inc1990-12-312012-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-diltiaz Tab 60mgtablet60 mgoralNu Pharm Inc1990-12-312012-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-diltiaz-CD Capsulescapsule (controlled-delivery)300 mgoralNu Pharm IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-diltiaz-CD Capsules 120mgcapsule (controlled-delivery)120 mgoralNu Pharm Inc1998-08-052012-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-diltiaz-CD Capsules 180mgcapsule (controlled-delivery)180 mgoralNu Pharm Inc1998-08-052012-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-diltiaz-CD Capsules 240mgcapsule (controlled-delivery)240 mgoralNu Pharm Inc1998-08-052012-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Penta-diltiazem - 30mgtablet30 mgoralPentapharm Ltd.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Penta-diltiazem - 60mgtablet60 mgoralPentapharm Ltd.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-diltiazem CDcapsule (controlled-delivery)180 mgoralPharmascience Inc2010-10-19Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-diltiazem CDcapsule (controlled-delivery)120 mgoralPharmascience Inc2010-10-19Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-diltiazem CDcapsule (controlled-delivery)300 mgoralPharmascience Inc2010-10-19Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-diltiazem CDcapsule (controlled-delivery)240 mgoralPharmascience Inc2010-10-19Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ratio-diltiazem CDcapsule (controlled-delivery)180 mgoralRatiopharm Inc Division Of Teva Canada Limited1997-01-022014-09-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ratio-diltiazem CDcapsule (controlled-delivery)300 mgoralRatiopharm Inc Division Of Teva Canada Limited1997-01-022014-09-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ratio-diltiazem CDcapsule (controlled-delivery)120 mgoralRatiopharm Inc Division Of Teva Canada Limited1997-01-022014-09-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ratio-diltiazem CDcapsule (controlled-delivery)240 mgoralRatiopharm Inc Division Of Teva Canada Limited1997-01-022014-09-19Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Diltiazem CDcapsule (extended release)240 mgoralSandoz Canada Incorporated2001-02-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Diltiazem CDcapsule (extended release)180 mgoralSandoz Canada Incorporated2001-02-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Diltiazem CDcapsule (extended release)120 mgoralSandoz Canada Incorporated2001-02-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Diltiazem CDcapsule (extended release)300 mgoralSandoz Canada Incorporated2001-02-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Diltiazem Tcapsule (extended release)360 mgoralSandoz Canada Incorporated2006-01-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Diltiazem Tcapsule (extended release)300 mgoralSandoz Canada Incorporated2006-01-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Diltiazem Tcapsule (extended release)240 mgoralSandoz Canada Incorporated2006-01-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Diltiazem Tcapsule (extended release)180 mgoralSandoz Canada Incorporated2006-01-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Diltiazem Tcapsule (extended release)120 mgoralSandoz Canada Incorporated2006-01-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Taro-diltiazem Tcapsule (extended release)360 mgoralTaro Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Taro-diltiazem Tcapsule (extended release)300 mgoralTaro Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Taro-diltiazem Tcapsule (extended release)240 mgoralTaro Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Taro-diltiazem Tcapsule (extended release)180 mgoralTaro Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Taro-diltiazem Tcapsule (extended release)120 mgoralTaro Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Taro-diltiazem Tab 30mgtablet30 mgoralTaro Pharmaceuticals Inc1996-12-312000-08-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Taro-diltiazem Tab 60mgtablet60 mgoralTaro Pharmaceuticals Inc1996-12-312000-08-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diltiazemtablet60 mgoralTeva Canada Limited1990-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diltiazemtablet30 mgoralTeva Canada Limited1990-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diltiazem CDcapsule (extended release)300 mgoralTeva Canada Limited2000-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diltiazem CDcapsule (extended release)240 mgoralTeva Canada Limited2000-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diltiazem CDcapsule (extended release)180 mgoralTeva Canada Limited2000-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diltiazem CDcapsule (extended release)120 mgoralTeva Canada Limited2000-10-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diltiazem HCl ER Capsulescapsule (extended release)360 mgoralValeant Canada Lp Valeant Canada S.E.C.2006-01-30Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diltiazem HCl ER Capsulescapsule (extended release)300 mgoralValeant Canada Lp Valeant Canada S.E.C.2006-01-30Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diltiazem HCl ER Capsulescapsule (extended release)240 mgoralValeant Canada Lp Valeant Canada S.E.C.2006-01-30Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diltiazem HCl ER Capsulescapsule (extended release)180 mgoralValeant Canada Lp Valeant Canada S.E.C.2006-01-30Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diltiazem HCl ER Capsulescapsule (extended release)120 mgoralValeant Canada Lp Valeant Canada S.E.C.2006-01-30Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tiazaccapsule (extended release)360 mgoralValeant Canada Lp Valeant Canada S.E.C.1997-06-09Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tiazaccapsule (extended release)300 mgoralValeant Canada Lp Valeant Canada S.E.C.1997-06-09Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tiazaccapsule (extended release)240 mgoralValeant Canada Lp Valeant Canada S.E.C.1997-06-09Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tiazaccapsule (extended release)180 mgoralValeant Canada Lp Valeant Canada S.E.C.1997-06-09Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tiazaccapsule (extended release)120 mgoralValeant Canada Lp Valeant Canada S.E.C.1997-06-09Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tiazac Extended Releasecapsule, extended release360 mg/1oralValeant Pharmaceuticals North America LLC2014-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tiazac Extended Releasecapsule, extended release300 mg/1oralCardinal Health2009-09-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tiazac Extended Releasecapsule, extended release300 mg/1oralValeant Pharmaceuticals North America LLC2014-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tiazac Extended Releasecapsule, extended release240 mg/1oralCardinal Health2009-09-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tiazac Extended Releasecapsule, extended release240 mg/1oralValeant Pharmaceuticals North America LLC2014-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tiazac Extended Releasecapsule, extended release180 mg/1oralCardinal Health2009-09-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tiazac Extended Releasecapsule, extended release180 mg/1oralValeant Pharmaceuticals North America LLC2014-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tiazac Extended Releasecapsule, extended release120 mg/1oralCardinal Health2009-09-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tiazac Extended Releasecapsule, extended release120 mg/1oralValeant Pharmaceuticals North America LLC2014-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tiazac Extended Releasecapsule, extended release420 mg/1oralCardinal Health2009-09-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tiazac Extended Releasecapsule, extended release420 mg/1oralValeant Pharmaceuticals North America LLC2014-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tiazac Extended Releasecapsule, extended release360 mg/1oralCardinal Health2009-09-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tiazac Xctablet (extended-release)240 mgoralValeant Canada Lp Valeant Canada S.E.C.2004-08-13Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tiazac Xctablet (extended-release)360 mgoralValeant Canada Lp Valeant Canada S.E.C.2004-08-13Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tiazac Xctablet (extended-release)180 mgoralValeant Canada Lp Valeant Canada S.E.C.2004-08-13Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tiazac Xctablet (extended-release)300 mgoralValeant Canada Lp Valeant Canada S.E.C.2004-08-13Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tiazac Xctablet (extended-release)120 mgoralValeant Canada Lp Valeant Canada S.E.C.2004-08-13Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tria-diltiazem 30mg Tabletstablet30 mgoralLaboratoires Trianon IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tria-diltiazem 60 Mg Tabletstablet60 mgoralLaboratoires Trianon IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Diltiaz Tab 30mgtablet30 mgoralApotex Inc1988-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo Diltiaz Tab 60mgtablet60 mgoralApotex Inc1988-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diltiaz CDcapsule (controlled-delivery)240 mgoralApotex Inc1997-03-27Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diltiaz CDcapsule (controlled-delivery)180 mgoralApotex Inc1997-03-27Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diltiaz CDcapsule (controlled-delivery)120 mgoralApotex Inc1997-03-27Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diltiaz CD - Cap 300mgcapsule (controlled-delivery)300 mgoralApotex Inc1996-09-12Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diltiaz Injectableliquid5 mgintravenousApotex Inc2000-06-202013-08-02Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diltiaz SR - 90mg/srccapsule (sustained-release)90 mgoralApotex Inc1996-09-19Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diltiaz SR - Src 120mgcapsule (sustained-release)120 mgoralApotex Inc1996-09-19Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diltiaz SR - Src 60mgcapsule (sustained-release)60 mgoralApotex Inc1996-09-19Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diltiaz TZcapsule (extended release)240 mgoralApotex Inc2008-07-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diltiaz TZcapsule (extended release)180 mgoralApotex Inc2008-07-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diltiaz TZcapsule (extended release)120 mgoralApotex Inc2008-07-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diltiaz TZcapsule (extended release)360 mgoralApotex Inc2008-07-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diltiaz TZcapsule (extended release)300 mgoralApotex Inc2008-07-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cartia Xtcapsule, extended release300 mg/1oralActavis Pharma, Inc.1999-06-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cartia Xtcapsule, extended release120 mg/1oralActavis Pharma, Inc.1999-06-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cartia Xtcapsule, extended release240 mg/1oralActavis Pharma, Inc.1999-06-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cartia Xtcapsule, extended release180 mg/1oralActavis Pharma, Inc.1999-06-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Dilacor XRcapsule, extended release240 mg/1oralWatson Pharma, Inc.1998-03-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Dilt-CDcapsule240 mg/1oralApotex Corp.2006-08-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Dilt-CDcapsule180 mg/1oralApotex Corp.2006-08-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Dilt-CDcapsule120 mg/1oralApotex Corp.2006-08-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Dilt-CDcapsule300 mg/1oralApotex Corp.2006-08-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralActavis Elizabeth LLC1999-12-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release90 mg/1oralMylan Institutional Inc.1999-12-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralREMEDYREPACK INC.2011-04-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mg/1oralLake Erie Medical DBA Quality Care Products LLC1995-12-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralOceanside Pharmaceuticals1999-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralApotex Corp.2001-07-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralbryant ranch prepack1995-12-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mg/1oralCardinal Health1995-12-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mg/1oralTeva Pharmaceuticals USA Inc1995-12-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralSandoz Inc2012-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralSun Pharma Global FZE2010-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mg/1oralPhysicians Total Care, Inc.2011-09-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralDispensing Solutions, Inc.1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralTEVA Pharmaceuticals USA Inc.1999-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralRebel Distributors Corp1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralMylan Pharmaceuticals Inc.1998-03-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralSun Pharma Global FZE2011-10-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralOceanside Pharmaceuticals1999-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release420 mg/1oralActavis Elizabeth LLC2012-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralAidarex Pharmaceuticals LLC1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralSandoz Inc2012-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralAmerican Health Packaging2010-01-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridepowder, for solution100 mg/1intravenousHospira, Inc.2011-10-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralMylan Institutional Inc.1996-03-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralSun Pharma Global FZE2010-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mg/1oralPhysicians Total Care, Inc.1995-04-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-07-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralTEVA Pharmaceuticals USA Inc.1999-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralRebel Distributors Corp1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release420 mg/1oralWatson Pharma, Inc.2010-03-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mg/1oralMylan Pharmaceuticals Inc.1992-03-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralREMEDYREPACK INC.2012-09-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralREMEDYREPACK INC.2011-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mg/1oralREMEDYREPACK INC.2015-07-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralCardinal Health2010-01-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralDispensing Solutions, Inc.1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralActavis Elizabeth LLC2012-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralAidarex Pharmaceuticals LLC1999-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralSandoz Inc2012-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralAmerican Health Packaging2010-01-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection, solution5 mg/mLintravenousHospira, Inc.2012-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mg/1oralMylan Institutional Inc.1996-03-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralSun Pharma Global FZE2011-10-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated90 mg/1oralPhysicians Total Care, Inc.1996-05-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-06-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralCardinal Health1992-11-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralTEVA Pharmaceuticals USA Inc.1999-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection5 mg/mLintravenousAkorn, Inc.2006-12-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-12-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release360 mg/1oralWatson Pharma, Inc.2010-03-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated90 mg/1oralMylan Pharmaceuticals Inc.1992-03-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralREMEDYREPACK INC.2013-03-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralREMEDYREPACK INC.2011-09-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralPd Rx Pharmaceuticals, Inc.1998-03-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release90 mg/1oralREMEDYREPACK INC.2015-07-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralCardinal Health2010-01-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralDispensing Solutions, Inc.1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralActavis Elizabeth LLC2012-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralAidarex Pharmaceuticals LLC1995-12-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection5 mg/mLintravenousWest Ward Pharmaceutical Corp.2008-12-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralAmerican Health Packaging2010-01-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralMylan Pharmaceuticals Inc.1997-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralUnit Dose Services1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralSun Pharma Global FZE2011-10-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralPhysicians Total Care, Inc.2005-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-07-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mg/1oralCardinal Health1992-11-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralTEVA Pharmaceuticals USA Inc.1999-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection5 mg/mLintravenousAkorn, Inc.2013-03-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated90 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-12-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release300 mg/1oralWatson Pharma, Inc.2010-03-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralMylan Pharmaceuticals Inc.1992-03-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralMylan Institutional Inc.2000-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralREMEDYREPACK INC.2013-03-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralAv Kare, Inc.2014-01-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralREMEDYREPACK INC.2016-01-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralPd Rx Pharmaceuticals, Inc.2011-09-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralActavis Elizabeth LLC2012-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralREMEDYREPACK INC.2013-03-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection5 mg/mLintravenousWest Ward Pharmaceutical Corp.2008-12-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release90 mg/1oralMylan Pharmaceuticals Inc.1997-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralUnit Dose Services1995-12-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralSun Pharma Global FZE2011-10-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated90 mg/1oralREMEDYREPACK INC.2015-06-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralCardinal Health2010-01-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, coated60 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-08-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated90 mg/1oralCardinal Health1992-11-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mg/1oralTeva Pharmaceuticals USA Inc1995-12-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection5 mg/mLintravenousAkorn, Inc.2013-11-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-12-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release240 mg/1oralWatson Pharma, Inc.2010-03-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mg/1oralMylan Pharmaceuticals Inc.1992-03-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralMylan Institutional Inc.2000-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet30 mg/1oralREMEDYREPACK INC.2011-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralAv Kare, Inc.2014-01-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralMc Kesson Contract Packaging2011-09-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralA S Medication Solutions Llc1995-12-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralActavis Elizabeth LLC2012-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralRebel Distributors Corp1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideinjection5 mg/mLintravenousWest Ward Pharmaceutical Corp.2008-12-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release60 mg/1oralMylan Pharmaceuticals Inc.1997-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralSun Pharma Global FZE2010-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralSt Marys Medical Park Pharmacy2014-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralPhysicians Total Care, Inc.2004-06-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mg/1oralPd Rx Pharmaceuticals, Inc.2011-11-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated90 mg/1oralTeva Pharmaceuticals USA Inc1995-12-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralMajor Pharmaceuticals2010-05-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-12-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release180 mg/1oralWatson Pharma, Inc.2010-03-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralActavis Elizabeth LLC2013-11-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralMylan Institutional Inc.2000-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralREMEDYREPACK INC.2011-06-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mg/1oralLake Erie Medical DBA Quality Care Products LLC1995-12-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated30 mg/1oralMc Kesson Contract Packaging2011-11-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, coated30 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-08-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralCardinal Health2011-07-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralMylan Pharmaceuticals Inc.1998-03-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralSun Pharma Global FZE2010-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralSt Marys Medical Park Pharmacy2013-07-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralPhysicians Total Care, Inc.2009-12-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralPd Rx Pharmaceuticals, Inc.2011-11-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralActavis Elizabeth LLC2012-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mg/1oralRebel Distributors Corp1992-11-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralAidarex Pharmaceuticals LLC2011-10-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release60 mg/1oralMylan Institutional Inc.1999-12-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule180 mg/1oralREMEDYREPACK INC.2011-08-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralOceanside Pharmaceuticals1999-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralApotex Corp.2001-07-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralActavis Elizabeth LLC1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralLake Erie Medical DBA Quality Care Products LLC1995-12-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralSandoz Inc2012-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralbryant ranch prepack1999-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, extended release120 mg/1oralWatson Pharma, Inc.2010-03-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralActavis Elizabeth LLC1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralMylan Institutional Inc.1999-12-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralREMEDYREPACK INC.2011-03-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralPreferred Pharmaceuticals, Inc.2011-03-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralApotex Corp.2001-07-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralbryant ranch prepack2010-11-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralCardinal Health1995-12-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralTeva Pharmaceuticals USA Inc1995-12-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release420 mg/1oralSandoz Inc2012-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralSun Pharma Global FZE2010-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralAmerican Health Packaging2015-03-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralPhysicians Total Care, Inc.2004-05-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralCardinal Health2007-07-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mg/1oralKAISER FOUNDATION HOSPITALS2012-02-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated60 mg/1oralRebel Distributors Corp1992-11-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralMylan Pharmaceuticals Inc.1998-03-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated90 mg/1oralMylan Institutional Inc.1996-03-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release360 mg/1oralSun Pharma Global FZE2011-10-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralOceanside Pharmaceuticals1999-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release180 mg/1oralActavis Elizabeth LLC1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridetablet, film coated120 mg/1oralAidarex Pharmaceuticals LLC1995-12-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release240 mg/1oralSandoz Inc2012-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release300 mg/1oralAmerican Health Packaging2010-01-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloridecapsule, extended release120 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release120 mg/1oralPar Pharmaceutical, Inc.1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release240 mg/1oralCardinal Health1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release180 mg/1oralCardinal Health2012-12-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release300 mg/1oralAmerican Health Packaging2012-12-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release300 mg/1oralPar Pharmaceutical, Inc.1999-12-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release240 mg/1oralAmerican Health Packaging2012-12-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release240 mg/1oralPar Pharmaceutical, Inc.1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release180 mg/1oralAmerican Health Packaging2012-12-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release120 mg/1oralCardinal Health2012-12-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release180 mg/1oralLake Erie Medical DBA Quality Care Products LLC1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release240 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release180 mg/1oralPar Pharmaceutical, Inc.1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release120 mg/1oralAmerican Health Packaging2012-12-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Releasecapsule, coated, extended release240 mg/1oralCardinal Health2012-12-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Release Extended Releasecapsule, coated, extended release180 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Release Extended Releasecapsule, coated, extended release120 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Release Extended Releasecapsule, coated, extended release300 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended Release Extended Releasecapsule, coated, extended release240 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1999-12-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochloride Extended-releasecapsule90 mg/1oralCardinal Health2011-08-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideextended Release Extended Releasecapsule, coated, extended release240 mg/1oralREMEDYREPACK INC.2013-05-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideextended Release Extended Releasecapsule, coated, extended release240 mg/1oralREMEDYREPACK INC.2016-01-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltiazem Hydrochlorideextended Release Extended Releasecapsule, coated, extended release120 mg/1oralREMEDYREPACK INC.2013-11-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltzaccapsule, extended release360 mg/1oralApotex Corp.2009-02-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltzaccapsule, extended release300 mg/1oralApotex Corp.2009-02-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltzaccapsule, extended release240 mg/1oralApotex Corp.2009-02-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltzaccapsule, extended release180 mg/1oralApotex Corp.2009-02-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diltzaccapsule, extended release120 mg/1oralApotex Corp.2009-02-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Matzim LAtablet, extended release360 mg/1oralActavis Pharma, Inc.2011-03-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Matzim LAtablet, extended release300 mg/1oralActavis Pharma, Inc.2011-03-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Matzim LAtablet, extended release240 mg/1oralActavis Pharma, Inc.2011-03-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Matzim LAtablet, extended release180 mg/1oralActavis Pharma, Inc.2011-03-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Matzim LAtablet, extended release120 mg/1oralActavis Pharma, Inc.2011-03-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Matzim LAtablet, extended release420 mg/1oralActavis Pharma, Inc.2011-03-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Taztia Xtcapsule, extended release360 mg/1oralAmerican Health Packaging2015-03-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Taztia Xtcapsule, extended release120 mg/1oralWatson Pharma, Inc.2003-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Taztia Xtcapsule, extended release360 mg/1oralWatson Pharma, Inc.2003-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Taztia Xtcapsule, extended release300 mg/1oralWatson Pharma, Inc.2003-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Taztia Xtcapsule, extended release240 mg/1oralWatson Pharma, Inc.2003-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Taztia Xtcapsule, extended release180 mg/1oralWatson Pharma, Inc.2003-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter ProductsNot Available
International Brands
NameCompany
AcalixRoemmers
AdizemMundipharma
AltiazemLusofarmaco
AnohealNot Available
CalcicardNot Available
CartiaNot Available
DilacorNot Available
Dilacor-XRWatson
DilcontinModi-Mundipharma
DilreneSanofi
Diltia XTNot Available
DilticardIntra
DilzemPfizer
HerbesserMitsubishi Tanabe
Incoril APBago
MasdilEsteve
SurazemNot Available
TAZTIANot Available
ViazemBiovail
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Diltiazem hydrochloride
ThumbNot applicableDBSALT000865
Diltiazem malate
ThumbNot applicableDBSALT001394
CategoriesNot Available
UNIIEE92BBP03H
CAS number42399-41-7
WeightAverage: 414.518
Monoisotopic: 414.16132802
Chemical FormulaC22H26N2O4S
InChI KeyInChIKey=HSUGRBWQSSZJOP-RTWAWAEBSA-N
InChI
InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
IUPAC Name
(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
SMILES
COC1=CC=C(C=C1)[C@@H]1SC2=CC=CC=C2N(CCN(C)C)C(=O)[C@@H]1OC(C)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzothiazepines. These are organic compounds containing a benzene fused to a thiazepine ring (a seven-membered ring with a nitrogen atom and a sulfur atom replacing two carbon atoms).
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzothiazepines
Sub ClassNot Available
Direct ParentBenzothiazepines
Alternative Parents
Substituents
  • Benzothiazepine
  • Methoxybenzene
  • Phenol ether
  • Anisole
  • Alkylarylthioether
  • Alkyl aryl ether
  • Benzenoid
  • Monocyclic benzene moiety
  • Acetate salt
  • Tertiary carboxylic acid amide
  • Tertiary aliphatic amine
  • Tertiary amine
  • Lactam
  • Carboxylic acid ester
  • Carboxamide group
  • Azacycle
  • Thioether
  • Ether
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
  • 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate (CHEBI:101278 )
Pharmacology
IndicationFor the treatment of Hypertension
PharmacodynamicsDiltiazem, a benzothiazepine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Diltiazem is a non-dihydropyridine (DHP)member of the calcium channel blocker class, along with Verapamil. Diltiazem is similar to other peripheral vasodilators. Diltiazem inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Mechanism of actionPossibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, diltiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.
AbsorptionDiltiazem is well absorbed from the gastrointestinal tract but undergoes substantial hepatic first-pass effect.
Volume of distributionNot Available
Protein binding70%-80%
Metabolism

Diltiazem is metabolized by and acts as an inhibitor of the CYP3A4 enzyme.

SubstrateEnzymesProduct
Diltiazem
N-DesmethyldiltiazemDetails
Route of eliminationNot Available
Half life3.0 - 4.5 hours
ClearanceNot Available
ToxicityLD50=740mg/kg (orally in mice)
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588
rs1801253 Not AvailableG > CBetter response to drug therapy22192668
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9788
Blood Brain Barrier+0.506
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.8645
P-glycoprotein inhibitor IInhibitor0.8675
P-glycoprotein inhibitor IIInhibitor0.8997
Renal organic cation transporterNon-inhibitor0.7634
CYP450 2C9 substrateNon-substrate0.699
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorInhibitor0.796
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8681
Ames testNon AMES toxic0.6985
CarcinogenicityNon-carcinogens0.8772
BiodegradationNot ready biodegradable0.9951
Rat acute toxicity2.4130 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9971
hERG inhibition (predictor II)Inhibitor0.7723
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Biovail laboratories inc
  • Watson laboratories inc florida
  • Watson laboratories inc
  • Apotex inc
  • Actavis elizabeth llc
  • Kv pharmaceutical co
  • Mylan pharmaceuticals inc
  • Teva pharmaceuticals usa inc
  • Apotex inc etobicoke site
  • Biovail corp international
  • Biovail laboratories international srl
  • Apotex inc richmond hill
  • Baxter healthcare corp anesthesia and critical care
  • Bedford laboratories div ben venue laboratories inc
  • Hospira inc
  • International medication systems ltd
  • Taylor pharmacal co
  • Teva parenteral medicines inc
  • Apothecon inc div bristol myers squibb
  • Dava pharmaceuticals inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Teva pharmaceuticals usa
  • Merck and co inc
Packagers
Dosage forms
FormRouteStrength
Capsule (controlled-delivery)oral120 mg
Capsule (controlled-delivery)oral180 mg
Capsule (controlled-delivery)oral240 mg
Capsule (controlled-delivery)oral300 mg
Capsule (sustained-release)oral90 mg
Capsule (sustained-release)oral120 mg
Capsule (sustained-release)oral60 mg
Tablet, coatedoral120 mg/1
Tablet, coatedoral30 mg/1
Tablet, coatedoral60 mg/1
Capsuleoral240 mg/1
Capsule (extended release)oral120 mg
Capsule (extended release)oral180 mg
Capsule (extended release)oral240 mg
Capsule (extended release)oral300 mg
Capsule, coated, extended releaseoral120 mg/1
Capsule, coated, extended releaseoral180 mg/1
Capsule, coated, extended releaseoral240 mg/1
Capsule, coated, extended releaseoral300 mg/1
Capsule, coated, extended releaseoral360 mg/1
Liquidintravenous5 mg
Tablet, extended releaseoral120 mg/1
Tablet, extended releaseoral180 mg/1
Tablet, extended releaseoral240 mg/1
Tablet, extended releaseoral300 mg/1
Tablet, extended releaseoral360 mg/1
Tablet, extended releaseoral420 mg/1
Capsuleoral120 mg/1
Capsuleoral300 mg/1
Injection, solutionintravenous.83 mg/mL
Injection, solutionintravenous1 mg/mL
Capsuleoral180 mg/1
Capsule, extended releaseoral120 mg/1
Capsule, extended releaseoral180 mg/1
Capsule, extended releaseoral240 mg/1
Capsule, extended releaseoral300 mg/1
Capsule, extended releaseoral60 mg/1
Capsule, extended releaseoral90 mg/1
Injectionintravenous5 mg/mL
Injection, solutionintravenous5 mg/mL
Powder, for solutionintravenous100 mg/1
Tabletoral30 mg/1
Tablet, film coatedoral120 mg/1
Tablet, film coatedoral30 mg/1
Tablet, film coatedoral60 mg/1
Tablet, film coatedoral90 mg/1
Capsuleoral90 mg/1
Solutionintravenous5 mg
Tabletoral30 mg
Tabletoral60 mg
Capsule (extended release)oral360 mg
Capsule, extended releaseoral360 mg/1
Capsule, extended releaseoral420 mg/1
Tablet (extended-release)oral120 mg
Tablet (extended-release)oral180 mg
Tablet (extended-release)oral240 mg
Tablet (extended-release)oral300 mg
Tablet (extended-release)oral360 mg
Prices
Unit descriptionCostUnit
Cormax 0.05% Solution 50ml Bottle81.6USD bottle
Cormax 0.05% Solution 25ml Bottle45.99USD bottle
Cormax 0.05% Cream 15 gm Tube43.98USD tube
Diltiazem hcl 100 mg vial9.54USD vial
Diltiazem hcl powder8.42USD g
Cardizem CD 360 mg 24 Hour Capsule7.94USD capsule
Cardizem cd 360 mg capsule7.63USD capsule
Cardizem CD 300 mg 24 Hour Capsule7.3USD capsule
Cardizem LA 420 mg 24 Hour tablet5.56USD tablet
Cardizem CD 240 mg 24 Hour Capsule5.48USD capsule
Cardizem la 420 mg tablet5.35USD tablet
Diltiazem HCl Coated Beads 420 mg 24 Hour tablet5.01USD tablet
Cardizem la 360 mg tablet4.94USD tablet
Cardizem LA 360 mg 24 Hour tablet4.81USD tablet
Cardizem LA 300 mg 24 Hour tablet4.71USD tablet
Diltiazem HCl Coated Beads 360 mg 24 Hour tablet4.62USD tablet
Cardizem la 300 mg tablet4.59USD tablet
Diltiazem HCl Coated Beads 300 mg 24 Hour tablet4.3USD tablet
Cardizem CD 180 mg 24 Hour Capsule3.98USD capsule
Tiazac 420 mg 24 Hour Capsule3.88USD capsule
Tiazac 360 mg 24 Hour Capsule3.7USD capsule
Cardizem LA 240 mg 24 Hour tablet3.67USD tablet
Tiazac 300 mg 24 Hour Capsule3.64USD capsule
Cardizem la 240 mg tablet3.53USD tablet
Cardizem 120 mg tablet3.49USD tablet
Cardizem CD 120 mg 24 Hour Capsule3.4USD capsule
Dilacor XR 180 mg 24 Hour Capsule3.3USD capsule
Dilacor XR 240 mg 24 Hour Capsule3.3USD capsule
Diltiazem HCl Coated Beads 240 mg 24 Hour tablet3.3USD tablet
Dilacor xr 240 mg capsule3.29USD capsule
Cardizem Cd 300 mg Controlled-Delivery Capsule3.25USD capsule
Cardizem la 180 mg tablet3.15USD tablet
Cardizem LA 180 mg 24 Hour tablet3.07USD tablet
Dilacor xr 180 mg capsule3.07USD capsule
Tiazac er 420 mg capsule3.03USD capsule
Cardizem la 120 mg tablet2.98USD tablet
Diltiazem HCl Coated Beads 180 mg 24 Hour tablet2.95USD tablet
Diltiazem HCl ER Beads 420 mg 24 Hour Capsule2.87USD capsule
Dilacor XR 120 mg 24 Hour Capsule2.86USD capsule
Tiazac er 360 mg capsule2.86USD capsule
Tiazac er 300 mg capsule2.83USD capsule
Tiazac 240 mg 24 Hour Capsule2.8USD capsule
Cartia XT 300 mg 24 Hour Capsule2.76USD capsule
Dilt-CD 300 mg 24 Hour Capsule2.76USD capsule
Diltiazem HCl Coated Beads 300 mg 24 Hour Capsule2.76USD capsule
Cormax 0.05% cream2.71USD g
Cartia xt 300 mg capsule2.66USD capsule
Dilt-cd er 300 mg capsule2.66USD capsule
Dilacor xr 120 mg capsule2.61USD capsule
Cardizem Cd 240 mg Controlled-Delivery Capsule2.6USD capsule
Diltiazem HCl ER Beads 360 mg 24 Hour Capsule2.44USD capsule
Tiazac 360 mg Extended-Release Capsule2.42USD capsule
Diltiazem HCl ER Beads 300 mg 24 Hour Capsule2.39USD capsule
Cardizem LA 120 mg 24 Hour tablet2.35USD tablet
Tiazac 240 mg capsule sa2.31USD capsule
Tiazac er 240 mg capsule2.18USD capsule
Cardizem cd 300 mg capsule2.15USD capsule
Cartia XT 240 mg 24 Hour Capsule2.13USD capsule
Diltiazem HCl Coated Beads 240 mg 24 Hour Capsule2.13USD capsule
Dilt-cd 240 mg capsule2.05USD capsule
Cardizem 90 mg tablet2.02USD tablet
Tiazac 180 mg 24 Hour Capsule1.98USD capsule
Tiazac 300 mg Extended-Release Capsule1.98USD capsule
Cardizem Cd 180 mg Controlled-Delivery Capsule1.96USD capsule
Diltiazem HCl ER Beads 240 mg 24 Hour Capsule1.85USD capsule
Cardizem sr 120 mg capsule1.83USD capsule
Apo-Diltiaz Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Novo-Diltazem Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Ratio-Diltiazem Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Sandoz Diltiazem Cd 300 mg Controlled-Delivery Capsule1.82USD capsule
Cardizem cd 240 mg capsule1.69USD capsule
Tiazac 120 mg 24 Hour Capsule1.69USD capsule
Tiazac 240 mg Extended-Release Capsule1.61USD capsule
Tiazac er 180 mg capsule1.52USD capsule
Cartia XT 180 mg 24 Hour Capsule1.5USD capsule
Dilt-CD 180 mg 24 Hour Capsule1.5USD capsule
Diltiazem HCl Coated Beads 180 mg 24 Hour Capsule1.5USD capsule
Cardizem Cd 120 mg Controlled-Delivery Capsule1.48USD capsule
Apo-Diltiaz Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Novo-Diltazem Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Nu-Diltiaz-Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Ratio-Diltiazem Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Sandoz Diltiazem Cd 240 mg Controlled-Delivery Capsule1.46USD capsule
Tiazac Xc 240 mg Extended-Release Tablet1.46USD tablet
Tiazac Xc 300 mg Extended-Release Tablet1.46USD tablet
Tiazac Xc 360 mg Extended-Release Tablet1.46USD tablet
Dilt-cd 180 mg capsule1.45USD capsule
Diltiazem HCl 120 mg tablet1.42USD tablet
Diltiazem 120 mg tablet1.36USD tablet
Apo-Diltiaz Tz 360 mg Extended-Release Capsule1.36USD capsule
Novo-Diltiazem Hcl Er 360 mg Extended-Release Capsule1.36USD capsule
Sandoz Diltiazem T 360 mg Extended-Release Capsule1.36USD capsule
Cardizem 30 mg tablet1.34USD tablet
Diltiazem HCl ER Beads 180 mg 24 Hour Capsule1.3USD capsule
Diltiazem HCl CR 120 mg 12 Hour Capsule1.29USD capsule
Tiazac er 120 mg capsule1.26USD capsule
Cartia XT 120 mg 24 Hour Capsule1.25USD capsule
Dilt-CD 120 mg 24 Hour Capsule1.25USD capsule
Diltiazem HCl Coated Beads 120 mg 24 Hour Capsule1.25USD capsule
Cardizem cd 180 mg capsule1.24USD capsule
Tiazac 180 mg Extended-Release Capsule1.21USD capsule
Cartia xt 120 mg capsule1.2USD capsule
Dilt-cd 120 mg capsule1.2USD capsule
Diltiazem HCl CR 240 mg 24 Hour Capsule1.19USD capsule
Diltia XT 240 mg 24 Hour Capsule1.17USD capsule
Diltiazem HCl CR 180 mg 24 Hour Capsule1.11USD capsule
Apo-Diltiaz Tz 300 mg Extended-Release Capsule1.11USD capsule
Novo-Diltiazem Hcl Er 300 mg Extended-Release Capsule1.11USD capsule
Sandoz Diltiazem T 300 mg Extended-Release Capsule1.11USD capsule
Tiazac Xc 180 mg Extended-Release Tablet1.1USD tablet
Diltia XT 180 mg 24 Hour Capsule1.1USD capsule
Apo-Diltiaz Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Novo-Diltazem Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Nu-Diltiaz-Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Ratio-Diltiazem Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Sandoz Diltiazem Cd 180 mg Controlled-Delivery Capsule1.1USD capsule
Diltiazem HCl ER Beads 120 mg 24 Hour Capsule1.08USD capsule
Diltiazem HCl 90 mg tablet1.05USD tablet
Diltiazem 90 mg tablet1.01USD tablet
Diltiazem HCl CR 90 mg 12 Hour Capsule0.99USD capsule
Cardizem cd 120 mg capsule0.97USD capsule
Cardizem 60 mg tablet0.95USD tablet
Diltiazem HCl CR 120 mg 24 Hour Capsule0.95USD capsule
Apo-Diltiaz Tz 240 mg Extended-Release Capsule0.9USD capsule
Novo-Diltiazem Hcl Er 240 mg Extended-Release Capsule0.9USD capsule
Sandoz Diltiazem T 240 mg Extended-Release Capsule0.9USD capsule
Tiazac 120 mg Extended-Release Capsule0.89USD capsule
Diltiazem HCl CR 60 mg 12 Hour Capsule0.86USD capsule
Apo-Diltiaz Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Novo-Diltazem Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Nu-Diltiaz-Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Ratio-Diltiazem Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Sandoz Diltiazem Cd 120 mg Controlled-Delivery Capsule0.83USD capsule
Tiazac Xc 120 mg Extended-Release Tablet0.83USD tablet
Cartia xt 240 mg capsule0.81USD capsule
Diltiazem HCl 60 mg tablet0.77USD tablet
Diltiazem 60 mg tablet0.74USD tablet
Apo-Diltiaz Tz 180 mg Extended-Release Capsule0.68USD capsule
Novo-Diltiazem Hcl Er 180 mg Extended-Release Capsule0.68USD capsule
Sandoz Diltiazem T 180 mg Extended-Release Capsule0.68USD capsule
Cartia xt 180 mg capsule0.6USD capsule
Apo-Diltiaz Tz 120 mg Extended-Release Capsule0.5USD capsule
Novo-Diltiazem Hcl Er 120 mg Extended-Release Capsule0.5USD capsule
Sandoz Diltiazem T 120 mg Extended-Release Capsule0.5USD capsule
Diltiazem HCl 30 mg tablet0.49USD tablet
Diltiazem 30 mg tablet0.47USD tablet
Diltia xt 240 mg capsule0.43USD capsule
Diltia xt 180 mg capsule0.42USD capsule
Diltiazem-d5w 250 mg/250 ml0.42USD ml
Diltia xt 120 mg capsule0.38USD capsule
Apo-Diltiaz 60 mg Tablet0.38USD tablet
Novo-Diltazem 60 mg Tablet0.38USD tablet
Nu-Diltiaz 60 mg Tablet0.38USD tablet
Apo-Diltiaz 30 mg Tablet0.22USD tablet
Novo-Diltazem 30 mg Tablet0.22USD tablet
Nu-Diltiaz 30 mg Tablet0.22USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
Canada21110851999-04-272012-06-25
Canada23075472007-08-142020-05-04
United States52864971994-05-202011-05-20
United States69239842001-02-252021-02-25
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point187-188Kugita, H., Inoue, H., Ikezaki, M. and Takeo, S.; U.S. Patent 3,562,257; assigned to Tanabe Seiyaku Co.,Ltd., Japan.
water solubility465 mg/L (at 25 °C)MCFARLAND,JW ET AL. (2001)
logP2.8Not Available
Caco2 permeability-4.38ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.0168 mg/mLALOGPS
logP3.09ALOGPS
logP2.73ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)12.86ChemAxon
pKa (Strongest Basic)8.18ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area59.08 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity114.37 m3·mol-1ChemAxon
Polarizability43.65 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
MSMass Spectrum (Electron Ionization)splash10-za00000000-b1095b8fe5973d23fdd6View in MoNA
References
Synthesis Reference

Kugita, H., Inoue, H., Ikezaki, M. and Takeo, S.; U.S. Patent 3,562,257; assigned to Tanabe Seiyaku Co.,Ltd., Japan.

US3562257
General ReferencesNot Available
External Links
ATC CodesC05AE03C08DB01
AHFS Codes
  • 24:28.92
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.2 KB)
Interactions
Drug Interactions
Drug
Acetylsalicylic acidDiltiazem may increase the anticoagulant activities of Acetylsalicylic acid.
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Diltiazem.
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Diltiazem.
AlfuzosinAlfuzosin may increase the hypotensive activities of Diltiazem.
AmifostineDiltiazem may increase the hypotensive activities of Amifostine.
AmiodaroneDiltiazem may increase the bradycardic activities of Amiodarone.
AmlodipineAmlodipine may increase the hypotensive activities of Diltiazem.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Diltiazem.
AprepitantThe serum concentration of Diltiazem can be increased when it is combined with Aprepitant.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Diltiazem.
AtorvastatinThe serum concentration of Diltiazem can be increased when it is combined with Atorvastatin.
AtosibanThe risk or severity of adverse effects can be increased when Diltiazem is combined with Atosiban.
Atracurium besylateDiltiazem may increase the neuromuscular blocking activities of Atracurium besylate.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Diltiazem.
BatimastatThe metabolism of Diltiazem can be decreased when combined with Batimastat.
BexaroteneThe serum concentration of Diltiazem can be decreased when it is combined with Bexarotene.
BosentanThe serum concentration of Diltiazem can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Diltiazem.
BretyliumBretylium may increase the bradycardic activities of Diltiazem.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Diltiazem.
BrimonidineBrimonidine may increase the antihypertensive activities of Diltiazem.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Diltiazem.
BuspironeThe metabolism of Buspirone can be decreased when combined with Diltiazem.
ButabarbitalThe metabolism of Diltiazem can be increased when combined with Butabarbital.
ButethalThe metabolism of Diltiazem can be increased when combined with Butethal.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Diltiazem.
CeritinibDiltiazem may increase the bradycardic activities of Ceritinib.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Diltiazem.
CimetidineThe serum concentration of Diltiazem can be increased when it is combined with Cimetidine.
ClarithromycinThe metabolism of Diltiazem can be decreased when combined with Clarithromycin.
ClonidineClonidine may increase the atrioventricular blocking (AV block) activities of Diltiazem.
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Diltiazem.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Diltiazem.
ColestipolColestipol can cause a decrease in the absorption of Diltiazem resulting in a reduced serum concentration and potentially a decrease in efficacy.
ConivaptanThe serum concentration of Diltiazem can be increased when it is combined with Conivaptan.
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Diltiazem.
DabrafenibThe serum concentration of Diltiazem can be decreased when it is combined with Dabrafenib.
DantroleneDantrolene may increase the hyperkalemic activities of Diltiazem.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Diltiazem.
DasatinibThe serum concentration of Diltiazem can be increased when it is combined with Dasatinib.
DeferasiroxThe serum concentration of Diltiazem can be decreased when it is combined with Deferasirox.
DiazoxideDiazoxide may increase the hypotensive activities of Diltiazem.
DigoxinDiltiazem may increase the atrioventricular blocking (AV block) activities of Digoxin.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Diltiazem.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Diltiazem.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Diltiazem.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Diltiazem.
DronedaroneDiltiazem may increase the atrioventricular blocking (AV block) activities of Dronedarone.
DuloxetineDiltiazem may increase the orthostatic hypotensive activities of Duloxetine.
EfavirenzThe serum concentration of Diltiazem can be decreased when it is combined with Efavirenz.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Diltiazem.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Diltiazem.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Diltiazem.
EsmololEsmolol may increase the bradycardic activities of Diltiazem.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Diltiazem.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Diltiazem.
FingolimodDiltiazem may increase the bradycardic activities of Fingolimod.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Diltiazem.
FluconazoleThe serum concentration of Diltiazem can be increased when it is combined with Fluconazole.
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Diltiazem.
FosaprepitantThe serum concentration of Diltiazem can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Diltiazem.
Fusidic AcidThe serum concentration of Diltiazem can be increased when it is combined with Fusidic Acid.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Diltiazem.
HeptabarbitalThe metabolism of Diltiazem can be increased when combined with Heptabarbital.
HexobarbitalThe metabolism of Diltiazem can be increased when combined with Hexobarbital.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Diltiazem.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Diltiazem.
IdelalisibThe serum concentration of Diltiazem can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Diltiazem resulting in a loss in efficacy.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Diltiazem.
IsoflurophateThe metabolism of Diltiazem can be decreased when combined with Isoflurophate.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Diltiazem.
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Diltiazem.
KetoconazoleThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Diltiazem.
LacosamideDiltiazem may increase the atrioventricular blocking (AV block) activities of Lacosamide.
LevodopaDiltiazem may increase the orthostatic hypotensive activities of Levodopa.
LithiumDiltiazem may increase the neurotoxic activities of Lithium.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Diltiazem.
LovastatinThe serum concentration of Diltiazem can be increased when it is combined with Lovastatin.
LuliconazoleThe serum concentration of Diltiazem can be increased when it is combined with Luliconazole.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Diltiazem.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Diltiazem is combined with Magnesium Sulfate.
MethohexitalThe metabolism of Diltiazem can be increased when combined with Methohexital.
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Diltiazem.
MidodrineDiltiazem may increase the bradycardic activities of Midodrine.
MifepristoneThe serum concentration of Diltiazem can be increased when it is combined with Mifepristone.
MitotaneThe serum concentration of Diltiazem can be decreased when it is combined with Mitotane.
MolsidomineMolsidomine may increase the hypotensive activities of Diltiazem.
MoxonidineMoxonidine may increase the hypotensive activities of Diltiazem.
NadololDiltiazem may increase the hypotensive activities of Nadolol.
NafcillinThe metabolism of Diltiazem can be increased when combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Diltiazem.
NelfinavirThe metabolism of Diltiazem can be decreased when combined with Nelfinavir.
NetupitantThe serum concentration of Diltiazem can be increased when it is combined with Netupitant.
NicorandilNicorandil may increase the hypotensive activities of Diltiazem.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Diltiazem.
NitroprussideDiltiazem may increase the hypotensive activities of Nitroprusside.
ObinutuzumabDiltiazem may increase the hypotensive activities of Obinutuzumab.
OctreotideOctreotide may increase the bradycardic activities of Diltiazem.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Diltiazem.
OxycodoneThe risk or severity of adverse effects can be increased when Diltiazem is combined with Oxycodone.
PalbociclibThe serum concentration of Diltiazem can be increased when it is combined with Palbociclib.
PentobarbitalThe metabolism of Diltiazem can be increased when combined with Pentobarbital.
PentoxifyllinePentoxifylline may increase the hypotensive activities of Diltiazem.
PhenelzinePhenelzine may increase the hypotensive activities of Diltiazem.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Diltiazem.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Diltiazem.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Diltiazem.
PrazosinPrazosin may increase the hypotensive activities of Diltiazem.
PrimidoneThe metabolism of Diltiazem can be increased when combined with Primidone.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Diltiazem.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Diltiazem.
QuinineQuinine may increase the hypotensive activities of Diltiazem.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Diltiazem.
RegorafenibRegorafenib may increase the bradycardic activities of Diltiazem.
RifabutinThe serum concentration of Diltiazem can be decreased when it is combined with Rifabutin.
RifampicinThe serum concentration of Diltiazem can be decreased when it is combined with Rifampicin.
RisperidoneDiltiazem may increase the hypotensive activities of Risperidone.
RituximabDiltiazem may increase the hypotensive activities of Rituximab.
RuxolitinibRuxolitinib may increase the bradycardic activities of Diltiazem.
Salicylate-sodiumDiltiazem may increase the anticoagulant activities of Salicylate-sodium.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Diltiazem.
SaquinavirThe serum concentration of Diltiazem can be increased when it is combined with Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Diltiazem.
SecobarbitalThe metabolism of Diltiazem can be increased when combined with Secobarbital.
SiltuximabThe serum concentration of Diltiazem can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Diltiazem.
SimvastatinThe serum concentration of Diltiazem can be increased when it is combined with Simvastatin.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Diltiazem.
St. John's WortThe serum concentration of Diltiazem can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Diltiazem can be increased when it is combined with Stiripentol.
SufentanilSufentanil may increase the bradycardic activities of Diltiazem.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Diltiazem.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Diltiazem.
TadalafilTadalafil may increase the antihypertensive activities of Diltiazem.
TesmilifeneThe serum concentration of Diltiazem can be decreased when it is combined with Tesmilifene.
TocilizumabThe serum concentration of Diltiazem can be decreased when it is combined with Tocilizumab.
TofacitinibTofacitinib may increase the bradycardic activities of Diltiazem.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Diltiazem.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Diltiazem.
TranylcypromineTranylcypromine may increase the hypotensive activities of Diltiazem.
TreprostinilTreprostinil may increase the hypotensive activities of Diltiazem.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Diltiazem.
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Diltiazem.
VardenafilVardenafil may increase the antihypertensive activities of Diltiazem.
VerapamilThe serum concentration of Diltiazem can be increased when it is combined with Verapamil.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Diltiazem.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Diltiazem.
YohimbineYohimbine may decrease the antihypertensive activities of Diltiazem.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Diltiazem.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Diltiazem.
Food Interactions
  • Avoid natural licorice.
  • Take this medication 30 minutes before meals.

Targets

1. Voltage-dependent calcium channel gamma-1 subunit

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Voltage-dependent calcium channel gamma-1 subunit Q06432 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Budriesi R, Ioan P, Carosati E, Cruciani G, Zhorov BS, Chiarini A: Ligands of diltiazem binding site: an overview of some chemotypes. Mini Rev Med Chem. 2009 Oct;9(12):1379-88. Pubmed
  4. Romero M, Sanchez I, Pujol MD: New advances in the field of calcium channel antagonists: cardiovascular effects and structure-activity relationships. Curr Med Chem Cardiovasc Hematol Agents. 2003 Jun;1(2):113-41. Pubmed

Enzymes

1. Cytochrome P450 3A4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  3. Williams JA, Ring BJ, Cantrell VE, Jones DR, Eckstein J, Ruterbories K, Hamman MA, Hall SD, Wrighton SA: Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab Dispos. 2002 Aug;30(8):883-91. Pubmed

2. Cytochrome P450 3A5

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 3A5 P20815 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 3A7

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 3A7 P24462 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.

4. Cytochrome P450 2C19

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C19 P33261 Details

References:

  1. Kosuge K, Jun Y, Watanabe H, Kimura M, Nishimoto M, Ishizaki T, Ohashi K: Effects of CYP3A4 inhibition by diltiazem on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status. Drug Metab Dispos. 2001 Oct;29(10):1284-9. Pubmed
  2. McGinnity DF, Parker AJ, Soars M, Riley RJ: Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s. Drug Metab Dispos. 2000 Nov;28(11):1327-34. Pubmed

5. Cytochrome P450 2D6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

6. Cytochrome P450 2C8

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C8 P10632 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

7. Cytochrome P450 2C9

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C9 P11712 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

Transporters

1. Multidrug resistance protein 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. Pubmed
  2. Takara K, Sakaeda T, Tanigawara Y, Nishiguchi K, Ohmoto N, Horinouchi M, Komada F, Ohnishi N, Yokoyama T, Okumura K: Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression. Eur J Pharm Sci. 2002 Aug;16(3):159-65. Pubmed
  3. Saeki T, Ueda K, Tanigawara Y, Hori R, Komano T: P-glycoprotein-mediated transcellular transport of MDR-reversing agents. FEBS Lett. 1993 Jun 7;324(1):99-102. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on November 27, 2015 16:15