Bacillus licheniformis bacitracin-resistance ABC transporter: relationship to mammalian multidrug resistance.
Article Details
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Podlesek Z, Comino A, Herzog-Velikonja B, Zgur-Bertok D, Komel R, Grabnar M
Bacillus licheniformis bacitracin-resistance ABC transporter: relationship to mammalian multidrug resistance.
Mol Microbiol. 1995 Jun;16(5):969-76. doi: 10.1111/j.1365-2958.1995.tb02322.x.
- PubMed ID
- 7476193 [ View in PubMed]
- Abstract
The nucleotide sequence of the Bacillus licheniformis bacitracin-resistance locus was determined. The presence of three open reading frames, bcrA, bcrB and bcrC, was revealed. The BcrA protein shares a high degree of homology with the hydrophilic ATP-binding components of the ABC family of transport proteins. The bcrB and bcrC genes were found to encode hydrophobic proteins, which may function as membrane components of the permease. Apart from Bacillus subtilis, these genes also confer resistance upon the Gram-negative Escherichia coli. The presumed function of the Bcr transporter is to remove the bacitracin molecule from its membrane target. In addition to the homology of the nucleotide-binding sites, BcrA protein and mammalian multidrug transporter or P-glycoprotein share collateral detergent sensitivity of resistant cells and possibly the mode of Bcr transport activity within the membrane. The advantage of the resistance phenotype of the Bcr transporter was used to construct deletions within the nucleotide-binding protein to determine the importance of various regions in transport.
DrugBank Data that Cites this Article
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Bacitracin Bacitracin transport ATP-binding protein BcrA Protein Bacillus licheniformis UnknownSubstrateDetails Bacitracin Bacitracin transport permease protein BCRB Protein Bacillus licheniformis UnknownSubstrateDetails Bacitracin Bacitracin transport permease protein BcrC Protein Bacillus licheniformis UnknownSubstrateDetails - Polypeptides
Name UniProt ID Bacitracin transport ATP-binding protein BcrA P42332 Details Bacitracin transport permease protein BCRB P42333 Details Bacitracin transport permease protein BcrC P42334 Details