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Identification
NameBacitracin
Accession NumberDB00626  (APRD00816)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Its unique name derives from the fact that the bacillus producing it was first isolated in 1943 from a knee scrape from a girl named Margaret Tracy. As a toxic and difficult-to-use antibiotic, bacitracin doesn’t work well orally. However, it is very effective topically.

Bacitracin is synthesised via the so-called nonribosomal peptide synthetases (NRPSs), which means that ribosomes are not involved in its synthesis.

Structure
Thumb
Synonyms
Bacitracin a2a
Bacitracin F, 1-(N-((2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl)carbonyl)-L-leucine)-
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Baciject 50,000 Units/vialpowder for solution50000 unitintramuscular; topicalSterimax Inc2003-08-28Not applicableCanada
Bacitracin for Injectionpowder for solution50000 unitintramuscular; topicalFresenius Kabi Canada LtdNot applicableNot applicableCanada
Bacitracin USPpowder for solution50000 unitintramuscular; topicalPfizer Canada Inc1951-12-31Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Baciiminjection, powder, lyophilized, for solution50000 [USP'U]/1intramuscularX Gen Pharmaceuticals, Inc.1997-05-09Not applicableUs
Bacitracininjection, powder, for solution50000 [iU]/9.8mLintramuscularPharmacia and Upjohn Company1948-07-29Not applicableUs
Bacitracinointment500 [iU]/gophthalmicFera Pharmaceuticals2010-01-11Not applicableUs
Bacitracinointment500 [iU]/gophthalmicRebel Distributors Corp2010-01-11Not applicableUs
Bacitracininjection, powder, lyophilized, for solution50000 [USP'U]/1intramuscularX Gen Pharmaceuticals, Inc.2015-10-08Not applicableUs
Bacitracininjection50000 [iU]/1intramuscularXellia Pharmaceuticals Ap S2013-01-31Not applicableUs
Bacitracininjection, powder, for solution50000 [iU]/1intramuscularAPP Pharmaceuticals, LLC2003-01-28Not applicableUs
Bacitracininjection, powder, for solution50000 [iU]/10mLintramuscularSagent Pharmaceuticals2010-08-10Not applicableUs
Bacitracinointment500 [iU]/gophthalmicPhysicians Total Care, Inc.1994-04-29Not applicableUs
Bacitracinointment500 [USP'U]/gophthalmicPaddock Laboratories, LLC2014-03-10Not applicableUs
Bacitracinointment500 [iU]/gophthalmicREMEDYREPACK INC.2013-06-10Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Antibioticointment500 [USP'U]/gtopicalMeijer Distribution Inc2015-04-15Not applicableUs
Antibiotic Bacitracin Zincointment500 [iU]/gtopicalMc Kesson2006-05-11Not applicableUs
Baciguent First Aid Ointmentointment500 unittopicalJohnson & Johnson Merck Consumer Pharmaceuticals Of Canada1997-12-192008-08-07Canada
Baciguent First Aid Ointment 500units/gmointment500 unittopicalUpjohn Consumer Products Company1995-12-312001-07-26Canada
Baciguent Ointment 500 Unitsointment500 unittopicalThe Upjohn Company Of Canada1951-12-311996-09-10Canada
Baciguent Oph Ont 500unit/gmointment500 unitophthalmicThe Upjohn Company Of Canada1975-12-311997-08-28Canada
Bacitinointment500 unittopicalPendopharm Division Of De Pharmascience Inc1984-12-31Not applicableCanada
Bacitracinointment500 [USP'U]/gtopicalPreferred Pharmaceuticals, Inc2012-04-30Not applicableUs
Bacitracinointment500 [iU]/gtopicalPhoenix Global Supply Group, Inc2011-04-01Not applicableUs
Bacitracinointment500 [USP'U]/gtopicalPerrigo New York Inc2011-06-20Not applicableUs
Bacitracinointment500 [iU]/gtopicalKinray Inc.2013-08-02Not applicableUs
Bacitracinointment500 [USP'U]/gtopicalMoore Medical LLC2012-07-12Not applicableUs
Bacitracinointment500 [USP'U]/gtopicalRebel Distributors Corp2011-06-20Not applicableUs
Bacitracinointment500 [iU]/gtopicalWater Jel Technologies2010-11-07Not applicableUs
Bacitracinointment500 [iU]/gtopicalDynarex Corporation2009-12-01Not applicableUs
Bacitracinointment500 [iU]/gtopicalProficient Rx LP2009-12-01Not applicableUs
Bacitracinointment500 [iU]/gtopicalSion Biotext Medical Ltd2012-07-09Not applicableUs
Bacitracinointment500 [USP'U]/gtopicalH E B1991-06-15Not applicableUs
Bacitracinointment500 [USP'U]/gtopicalCVS Pharmacy2005-06-08Not applicableUs
Bacitracinointment500 [USP'U]/gtopicalREMEDYREPACK INC.2016-04-12Not applicableUs
Bacitracinointment500 [iU]/gtopicalGalentic Pharma (India) Priva Te Limited2013-08-02Not applicableUs
Bacitracinointment500 [USP'U]/gtopicalDenison Pharmaceuticals, Inc.1979-08-22Not applicableUs
Bacitracinointment500 [USP'U]/gtopicalG&W Laboratories, Inc.1995-01-10Not applicableUs
Bacitracinointment500 [USP'U]/gtopicalLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-19Not applicableUs
Bacitracinointment500 [USP'U]/gtopicalCardinal Health2011-06-20Not applicableUs
Bacitracinointment500 [USP'U]/gtopicalSafeway2015-04-07Not applicableUs
Bacitracinointment500 [USP'U]/gtopicalPhysicians Total Care, Inc.1979-08-22Not applicableUs
Bacitracinointment500 [iU]/gtopicalBlossom Pharmaceuticals2014-03-06Not applicableUs
Bacitracin Antibioticointment500 unittopicalWater Jel Technologies,LlcNot applicableNot applicableCanada
Bacitracin Ointmentointment500 unittopicalSafetec Of America IncNot applicableNot applicableCanada
Bacitracin Ointment 500 Units/gointment500 unittopicalWellspring Pharmaceutical Canada Corp1997-04-012005-07-20Canada
Bacitracin Ont 500unit/gmointment500 unittopicalGlaxo Canada Inc1960-12-311998-07-30Canada
Bacitracin Zincointment500 [USP'U]/gtopicalTaro Pharmaceuticals U.S.A., Inc.2006-05-11Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalE. Fougera & CO., A division of Fougera Pharmaceuticals Inc.2010-01-08Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalA S Medication Solutions Llc2010-01-08Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalDynarex Corporation2009-12-01Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalKroger Company2012-02-23Not applicableUs
Bacitracin Zincointment500 [iU]/gtopicalSion Biotext Medical Ltd2012-07-06Not applicableUs
Bacitracin Zincointment500 [iU]/gtopicalGeritrex Corp2014-07-23Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalTrifecta Pharmaceuticals Usa Llc2016-04-07Not applicableUs
Bacitracin Zincointment500 [iU]/gtopicalGalentic Pharma (India) Priva Te Limited2013-08-06Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalFamily Dollar Services Inc.2012-02-23Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalWalgreen Company2014-05-31Not applicableUs
Bacitracin Zincointment500 [iU]/gtopicalGeritrex Corp2014-05-15Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalKareway Product, Inc.2012-07-24Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalDiscount Drug Mart, Inc.2015-11-09Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalRebel Distributors Corp2010-01-08Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalREMEDYREPACK INC.2015-03-04Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalQualitest Pharmaceuticals2001-09-01Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalCardinal Health2011-06-02Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalBlossom Pharmaceuticals2014-05-14Not applicableUs
Bacitracin Zincointment500 [iU]/gtopicalDynarex Corporation2009-12-01Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalDolgencorp, LLC2010-03-02Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalE. Fougera & CO., A division of Fougera Pharmaceuticals Inc.2010-01-08Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalH.J. Harkins Company, Inc.2010-01-08Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalPromex, LLC2013-12-02Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalActavis Pharma, Inc.2002-03-01Not applicableUs
Bacitracin Zincointment500 [iU]/gtopicalDynarex Corporation2009-12-01Not applicableUs
Bacitracin Zincointment500 [USP'U]/gtopicalAidarex Pharmaceuticals LLC2002-03-01Not applicableUs
Bacitracin Zinc Ointment USPointment500 unittopicalDynarex Corporation2011-11-03Not applicableCanada
Bacitracine 500 Iu Ointmentointment500 unittopicalJamp Pharma Corporation2010-03-042010-05-14Canada
Band-aid Brand Adhesive Bandages Plus Antibioticointment500 unittopicalJohnson & Johnson IncNot applicableNot applicableCanada
Best Choice Bacitracin Zincointment500 [USP'U]/gtopicalValu Merchandisers, Co.2012-07-24Not applicableUs
Budpak Bacitracinointment500 [iU]/gtopicalBudpak Inc.2015-03-30Not applicableUs
Cardinal Health First Aid Antibioticointment500 U/gtopicalCardinal Health2015-08-27Not applicableUs
Careall Bacitracincream500 [USP'U]/gtopicalNew World Imports, Inc2012-06-01Not applicableUs
Careone Bacitracinointment500 [USP'U]/gtopicalAmerican Sales Company2012-03-01Not applicableUs
Equaline Bacitracin Zincointment500 [iU]/gtopicalSupervalu Inc2006-05-11Not applicableUs
Face Values Bacitracinointment500 [USP'U]/gtopicalHarmon Stores Inc.2012-04-01Not applicableUs
Family Care Bacitracinointment500 [USP'U]/gtopicalUNITED EXCHANGE CORP.2012-03-01Not applicableUs
Family Care Bacitracin Anti-infectionointment500 [USP'U]/gtopicalUNITED EXCHANGE CORP.2014-12-03Not applicableUs
First Aid Antibioticointment500 [USP'U]/gtopicalCVS Pharmacy2006-04-25Not applicableUs
First Aid Antibioticointment500 [USP'U]/gtopicalMedline Industries, Inc.2010-03-01Not applicableUs
First Aid Antibiotic Bacitraycin Pluscream500 [USP'U]/gtopicalFirst Aid Research Corp.2013-06-30Not applicableUs
First Aid Antibiotic Ointmentointment500 unittopicalZee Medical Inc2011-02-01Not applicableCanada
First Aid Bacitracin Zincointment500 [USP'U]/gtopicalRite Aid2006-06-16Not applicableUs
First Aid Original Bacitraycin Plusointment500 [USP'U]/gtopicalFirst Aid Research Corp.2014-03-05Not applicableUs
First Aid Research Bacitracin With Zincointment500 [iU]/gtopicalTAI GUK PHARM. CO., LTD.2010-04-07Not applicableUs
Good Neighbor Pharmacy Bacitracin Zincointment500 [iU]/gtopicalAmerisource Bergen2006-05-11Not applicableUs
Health Mart Pharmacy Bacitracin Zinc First Aid Antibioticointment500 [USP'U]/gtopicalHealth Mart1990-12-05Not applicableUs
Jamp-bacitracineointment500 unittopicalJamp Pharma Corporation2010-05-27Not applicableCanada
Kaiser Permanente Bacitracin Zincointment500 [iU]/gtopicalKAISER FOUNDATION HOSPITALS2006-05-11Not applicableUs
Leader Bacitracinointment500 [USP'U]/gtopicalCardinal Health2012-02-15Not applicableUs
Lincolnointment500 [USP'U]/gtopicalLincoln Pharmaceuticals Ltd.2013-05-30Not applicableUs
Live Better Bacitracin Zincointment500 [iU]/gtopicalThe Great Atlantic & Pacific Tea Company2006-05-11Not applicableUs
Lucky Supersoft First Aidointment500 [USP'U]/gtopicalDelta Brands Inc2015-01-31Not applicableUs
Medichoice Bacitracinointment500 [iU]/gtopicalOwens & Minor Inc2015-03-26Not applicableUs
Medpride First Aidointment500 [USP'U]/gtopicalShield Line LLC2013-05-30Not applicableUs
Meijer Bacitracin Zincointment500 [iU]/gtopicalMeijer Distribution Inc2006-05-11Not applicableUs
Original Bacitraycincream500 unittopicalFirst Aid Research CorporationNot applicableNot applicableCanada
Premier Value Bacitracin Zincointment500 [iU]/gtopicalChain Drug Consortium2006-05-11Not applicableUs
Procurefirst Aid Antibio First Aid Antibioticointment500 U/gtopicalTWIN MED, LLC2013-02-05Not applicableUs
Publix Bacitracin Zincointment500 [iU]/gtopicalPublix Super Markets Inc2006-05-11Not applicableUs
Quality Choice Bacitracinointment500 [USP'U]/gtopicalChain Drug Marketing Association Inc2012-02-13Not applicableUs
Rexall Antibioticointment500 [USP'U]/gtopicalDolgencorp, LLC2015-09-22Not applicableUs
Safeway Bacitracin Zincointment500 [iU]/gtopicalSafeway Inc.2006-05-11Not applicableUs
Schein Bacitracinointment500 [iU]/gtopicalHenry Schein, Inc.2011-12-04Not applicableUs
Sheffield Bacitracin Zincointment500 [USP'U]/gtopicalFaria LLC dba Sheffield Pharmaceuticals2012-09-25Not applicableUs
Shopko Bacitracin Zincointment500 [iU]/gtopicalShopko Stores Operating Co., LLC2006-05-11Not applicableUs
Shoprite Bacitracinointment500 [USP'U]/gtopicalWakefern Food Corporation2015-09-16Not applicableUs
Signature Care First Aid Antibioticointment500 [USP'U]/gtopicalSafeway2015-09-14Not applicableUs
Single Antibiotic With Bacitracinointment400 [USP'U]/gtopicalSafetec of America2008-11-13Not applicableUs
Smart Sense Antibioticointment500 [USP'U]/gtopicalKmart Corporation2010-12-14Not applicableUs
Taro-bacitracin Ointment 500units/gmointment500 unittopicalTaro Pharmaceuticals Inc1995-12-31Not applicableCanada
Topcare Bacitracin Zincointment500 [iU]/gtopicalTopco Associates LLC2006-05-11Not applicableUs
Touchless Care First Aid Antibioticspray500 [USP'U]/gtopicalCrawford Healthcare, Inc.2014-12-29Not applicableUs
Ultra Seal Bacitracinointment500 [iU]/gtopicalUltra Seal Corporation2011-12-04Not applicableUs
Up and Up Bacitracin First Aidointment500 [USP'U]/gtopicalTarget Corporation2009-11-29Not applicableUs
Up and Up First Aid Antibioticointment500 [USP'U]/gtopicalTarget Corporation2015-04-06Not applicableUs
Walgreens Bacitracin Zincointment500 [USP'U]/gtopicalWalgreen Company2006-05-11Not applicableUs
Western Family Bacitracin Zincointment500 [iU]/gtopicalWestern Family Foods Inc2006-05-11Not applicableUs
Winco Bacitracinointment500 [USP'U]/gtopicalWin Co Foods, Llc2015-02-09Not applicableUs
Zapotol Bacitracincream500 [USP'U]/gtopicalZapatol Corp.2014-08-06Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Bacitracinointment500 1/1topicalCardinal Health2011-06-02Not applicableUs
International Brands
NameCompany
BaciguentUpjohn
Brand mixtures
NameLabellerIngredients
10 Person AnsiGenuine First Aid LLC
25 Person AnsiGenuine First Aid LLC
50 Person AnsiGenuine First Aid LLC
Acme First Aid Contains 404 PiecesAcme United Corp.
Acme Small Cuts and BurnsAcme United Corp.
AerosootheAero Healthcare Us Llc
Ak-poly-bacAkorn, Inc.
American Red Cross First Aid KitTomy International
Antibiotic and Pain ReliefRite Aid Corporation
Antibiotic and Pain Relief Maximum StrengthCVS Pharmacy
Antibiotic Maximum StrengthWalgreen Company
Antibiotic OintmentPharmascience Inc
Antibiotic Ointment USPTaro Pharmaceuticals Inc
Antibiotic Original StrengthCVS Pharmacy
Antibiotique OnguentProdemdis Enr.
Arc First Aid Contains 1000 PiecesAmerican Red Cross
Arc First Aid Contains 404 PiecesAmerican Red Cross
Atopalm First Aid Triple AntibioticNeoPharm Co., Ltd.
Atopalm First Aid Triple Antibiotic Protection Moisturizing and Pain ReliefNeoPharm Co., Ltd.
Baciguent Plus Pain Reliever OntUpjohn Consumer Products Company
Bacimyxin OnguentPharmascience Inc
Bacitracin Zinc and Polymyxin B SulfateE. FOUGERA & CO., A division of Nycomed US Inc.
Bacitracin Zinc, Neomycin Sulfate and Polymyxin B SulfateGalentic Pharma (India) Private Limited
Band-aid Brand Adhesive Bandages Plus AntibioticJohnson & Johnson Inc
Band-aid-S-1Johnson & Johnson Inc
Berkley and Jensen Triple AntibioticBJWC
Bioderm OintmentOdan Laboratories Ltd
Biotic-plusProvision Medical
Bp MyxinLaboratoires Sterigen Inc
Budpak Triple Antibiotic Maximum StrengthBudpak Inc.
Cardinal Health First Aid AntibioticCardinal Health
Careall Triple AntibioticNew World Imports, Inc
Careone Original Strength Triple AntibioticFoodhold U.S.A. Llc
Careone Triple AntibioticAmerican Sales Company
Cicatrin PowderGlaxosmithkline Inc
Complete Antibiotic OintmentTaro Pharmaceuticals Inc
CortisporinPfizer Laboratories Div Pfizer Inc
CortomycinMajor Pharmaceuticals
CuadridermaPro Mex Llc
Cvp Triple AntibioticSalado Sales, Inc
Cvs Bacitracin With Pain ReliefCVS Pharmacy
Daymark Fak-35 First AidCmc Group
Dg Health AntibioticDolgencorp, LLC
Dg Health Triple AntibioticDolgencorp Inc
Diosporin OintmentDioptic Pharmaceuticals Inc
Double AntibioticE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.
Dr Bells PomadeGenomma Lab Usa Inc.
Dr Teals Triple AntibioticAdvanced Beauty Systems, Inc.
Equaline First Aid AntibioticSupervalu Inc
Equaline Triple AntibioticSupervalu Inc
Equaline Triple Antibiotic PlusSupervalu Inc
Exchange Select First Aid Triple Anitbiotic Pain RelievingArmy & Air Force Exchange Service
Exchange Select Triple AntibioticArmy & Air Force Exchange Service
Extra Strength Bacitraycin PlusFirst Aid Research Corporation
Face Values Triple AntibioticHarmon Stores Inc.
Family Care Triple AntibioticUNITED EXCHANGE CORP.
Family Care Triple Antibiotic Plus Pain ReliefUNITED EXCHANGE CORP.
Family WellnessZhejiang Jingwei Pharmaceutical Co., Ltd.
First Aid AntibioticHy Vee Inc
First Aid Antibiotic OintmentJohnson & Johnson Inc
First Aid Antibiotic Plus Pain Relief Maximum StrengthRite Aid
First Aid Double AntibioticRite Aid
First Aid Macimum Sterngth Bacitraycin PlusFirst Aid Research Corp
First Aid Pocket Pack - 40 PiecesReady America, Inc.
First Aid Research Bacitraycin Plus Maximum VerticalFirst Aid Research Corp.
First Aid Triple AntibioticRite Aid
First Aid Triple Antibiotic and Pain Relief Maximum StrengthLif Elabs, A Division Of Atico International Usa, Inc.
First Aid Triple Antibiotic With Pain RelieverCintas First Aid & Safety
First Aid Value Pack - 77 PiecesReady America, Inc.
Formucare Triple Antibiotic Original StrengthAccess Business Group LLC
Fulton Street Market Triple Antibiotic Original StrengthAccess Business Group LLC
Genuine First Aid - Auto First AidGenuine First Aid, LLC
Genuine First Aid - Home First AidGenuine First Aid, LLC
Genuine First Aid Emergency Preparedness Contains 167 Pieces HardcaseGenuine First Aid LLC
Genuine First Aid Industrial First AidGenuine First Aid, LLC
Genuine Triple AntibioticGenuine First Aid LLC
Gfa First AidGenuine First Aid, LLC
Gfa First Aid 16 Unit Metal CaseGenuine First Aid, LLC
Gfa First Aid 24 Unit Metal CaseGenuine First Aid, LLC
Gfa First Aid 36 Unit Metal CaseGenuine First Aid, LLC
Gfa First Aid Kit Essentials - 33 PiecesGenuine First Aid, LLC
Good Neighbor Pharmacy Emergency Preparedness and First Aid Contains 167 PiecesAmerisource Bergen
Good Neighbor Pharmacy First AidAmerisource Bergen
Good Neighbor Pharmacy Triple AntibioticAmerisource Bergen
Good Neighbor Pharmacy Triple Antibiotic Plus Pain ReliefAmerisource Bergen
Good Sense First Aid AntibioticL. Perrigo Company
Good Sense Triple AntibioticL Perrigo Company
Good Sense Triple Antibiotic and Pain ReliefL. Perrigo Company
Healthy Accents Triple AntibioticDZA Brands LLC
JampolycinJamp Pharma Corporation
Kaiser Permanente Double AntibioticKaiser Foundations Hospitals
Lanabiotic OntCombe Incorporated
Leader First Aid AntibioticCardinal Health
Leader Triple AntibioticCardinal Health
Leader Triple Antibiotic PlusCardinal Health
LincolnLincoln Pharmaceutical Ltd.
Live Better Triple AntibioticThe Great Atlantic & Pacific Tea Company
Live Better Triple Antibiotic Plus Pain ReliefThe Great Atlantic & Pacific Tea Company
Lucky Supersoft First AidDelta Brands, Inc
Makesense First AidCherry Hill Sales Co
Market Basket First Aid Triple AntibioticDavion, Inc.
Medi-firstMedique Products
Medichoice Triple AntibioticOwens & Minor Inc.
Medpride First AidShield Line LLC
Meijer Triple AntibioticMeijer Distribution Inc
Meijer Triple Antibiotic PlusMEIJER, INC.
Meijer Triple Antibiotic Plus Pain ReliefMeijer Distribution Inc
Mountain Series Weekender MedicalTender Corporation Dba Adventure Medical Kits
Neo Bace Ophthalmic OintmentPharmavite Laboratories (1987) Inc.
Neo PolycinPaddock Laboratories, LLC
Neo Polycin HCPaddock Laboratories, LLC
Neo-poly-bacButler Animal Health Supply
Neo-poly-bac HydroButler Animal Health Supply
Neo-polycinRebel Distributors Corp
Neo-polycin HCFera Pharmaceuticals
NeocidinMajor Pharmaceuticals
Neomycin and Polymyxin B Sulfates and Bacitracin ZincRxv
Neomycin and Polymyxin B Sulfates and Bacitracin Zinc With Hydrocortisone AcetateRebel Distributors Corp
Neomycin and Polymyxin B Sulfates, and Bacitracin ZincHenry Schein Inc.
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and HydrocortisoneMwi/Vet One
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and HydrocortisoneHenry Schein Inc.
Neomycin Sulfate, Polymyxin B Sulfate and Bacitracin ZincSTAT Rx USA LLC
Neosporin OintmentGlaxosmithkline Inc
Neosporin Ophthalmic OintmentGlaxosmithkline Inc
Neosporin OriginalJohnson & Johnson Consumer Products Company, Division of Johnson & Johnson Consumer Companies, Inc.
Neosporin Pain Itch ScarJohnson & Johnson Consumer Inc.
Neosporin Plus Pain ReliefJohnson & Johnson Consumer Inc.
Neosporin Plus Pain Relief Neo To GoJohnson & Johnson Consumer Products Company, Division of Johnson & Johnson Consumer Companies, Inc.
Neosporin Plus Pain Relief Neo To Go First Aid Antibiotic Pain RelievingJohnson & Johnson Consumer Products Company, Division of Johnson & Johnson Consumer Companies, Inc.
Neotopic OintmentTechnilab Pharma Inc.
North Triple AntibioticNorth Safety Products
Onguent AntibiotiqueTherapharma Inc.
Optimyxin Ophthalmic OintmentSandoz Canada Incorporated
Our Family Triple AntibioticNash Finch Company
Ozonol Antibiotic Plus - OintmentBayer Inc Consumer Care
Ozonol Antibiotic Plus OntSterling Winthrop Inc.
Ozonol Antibiotics PlusBayer Inc Consumer Care
Paraid Triple AntibioticMcure Health Solutions Inc.
Pentrexcilina Triple AntibioticOpmx Llc
Polvos De Sulpha First Aid AntibioticMenper Distributors Inc.
Poly AntibioticDolgencorp, LLC
Poly BacitracinPhoenix Global Supply Group, Inc
Polycidin Ophthalmic OintmentNovartis Ophthalmics Novartis Pharmaceuticals (Canada) Inc
PolycinPaddock Laboratories, LLC
Polyderm Antibiotic OintmentPharmetics (2011) Inc
Polyderm Ointment USPTaro Pharmaceuticals Inc
PolysporinJohnson & Johnson Consumer Products Company, Division of Johnson & Johnson Consumer Companies, Inc.
Polysporin Antibiotic OintmentWarner Lambert Canada Inc.
Polysporin Cold Sore OintmentJohnson & Johnson Inc
Polysporin CompleteJohnson & Johnson Inc
Polysporin First Aid AntibioticJohnson & Johnson Consumer Inc.
Polysporin for StitchesJohnson & Johnson Inc
Polysporin Sterile Ophthalmic OintmentJohnson & Johnson Inc
Polysporin Topical First Aid Antibiotic OintmentGlaxo Wellcome Inc.
Polysporin Triple Antibiotic OintmentGlaxo Wellcome Inc.
PolytopicSandoz Canada Incorporated
Polytopic OntTechnilab Pharma Inc.
Pomada De LA Campana Triple Antibiotic Pain ReliefGenomma Lab Usa, Inc.
Premier Value Triple AntibioticChain Drug Consortium
Premier Value Triple Antibiotic PlusTAI GUK PHARM. CO., LTD.
ProcomycinPhysicians Science & Nature Inc.
Procuretriple Antibiotic Triple AntibioticTWIN MED, LLC
Publix AntibioticPublix Super Markets Inc
Publix Antibiotic Plus Pain ReliefPublix Super Markets Inc
Quality Choice Maximum Strength Triple AntibioticChain Drug Marketing Association Inc
Quality Choice Triple AntibioticChain Drug Marketing Association Inc
Quality Choice Triple Antibiotic Plus Pain RelieverChain Drug Marketing Association Inc
Rash Relief AntibacterialTouchless Care Concepts LLC
Ready America First Aid Outdoor- 107 PiecesGenuine First Aid, LLC
Ready America First Aid Pocket - 33 PiecesGenuine First Aid, LLC
Repara Triple AntibioticPSS World Medical, Inc.
Sandoz CortimyxinSandoz Canada Incorporated
Schein Triple AntibioticHenry Schein, Inc.
Select Medical Products Triple AntibioticPSS World Medical, Inc.
Sheffield Triple AntibioticFaria LLC dba Sheffield Pharmaceuticals
Sheffield Triple Antibiotic Plus Pain ReliefFaria LLC dba Sheffield Pharmaceuticals
Shopko Triple AntibioticShopko Stores Operating Co., LLC
Shopko Triple Antibiotic PlusUNITED EXCHANGE CORP.
Shopko Triple Antibiotic Plus Pain ReliefShopko Stores Operating Co., LLC
Shoprite Triple AntibioticWakefern Food Corporation
Signature Care Triple AntibioticSafeway
Small Cuts and BurnsGenuine First Aid LLC
Smart Sense Triple AntibioticKmart Corporation
Smart Sense Triple Antibitotic Plus Pain ReliefKmart Corporation
Sunmark Double AntibioticMc Kesson
Sunmark Triple AntibioticMc Kesson
Sunmark Triple Antibiotic Plus Pain ReliefMc Kesson
Theraplusplus PlusZhejiang Jingwei Pharmaceutical Co., Ltd.
Topcare Triple AntibioticTopco Associates LLC
Topcare Triple Antibiotic Plus Pain ReliefTopco Associates LLC
Topical Antibiotic OintmentCrls
TribioticHART Health
Tribioticlc Lc LcHART Health
Triple AntibioticE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.
Triple Antibiotic and Pain Relief Maximum StrengthCVS Pharmacy
Triple Antibiotic Extra StrengthPersonal Care Products, Inc.
Triple Antibiotic First AidUniversal Distribution Center LLC
Triple Antibiotic First Aid AntibioticNatureplex LLC
Triple Antibiotic HCPhoenix Pharmaceutical, Inc.
Triple Antibiotic Maximum StrengthBudpak Inc.
Triple Antibiotic OintmentG&W Laboratories, Inc.
Triple Antibiotic PlusG&W Laboratories, Inc.
Triple Antibiotic Plus Maximum StrengthH E B
Triple Antibiotic Plus Pain ReliefMeijer Distribution Inc
Triple Antibiotic Plus Pain Relief Maximum StrengthKroger Company
Triple Antibiotic With Pain Relief Maximum StrengthWalgreen Company
Ultra Seal Triple AntibioticUltra Seal Corporation
Up and Up AntibioticTarget Corporation
Up and Up Antibiotic Plus Pain ReliefTarget Corporation
Up and Up First Aid Antibiotic Pain RelievingTarget Corporation
Wal-sporinWalgreen Company
Walgreens Maximum Strength Triple Antibiotic With Pain ReliefWALGREEN CO.
Walgreens Triple AntibioticWalgreen Company
Walgreenstriple AntibioticWalgreen Company
Water-jel 3-IN-1 AntibioticWater Jel Technologies
Well At Walg Triple Antibiotic Well At WalgreensWalgreens
Western Family Triple AntibioticWestern Family Foods Inc
Western Family Triple Antibiotic Plus Pain ReliefWestern Family Foods Inc
Winco Maximum Strength Triple AntibioticWin Co Foods, Llc
Winco Original Strength Triple AntibioticWin Co Foods, Llc
Salts
Name/CASStructureProperties
Bacitracin methylene disalicylate
ThumbNot applicableDBSALT001613
Bacitracin zinc
ThumbNot applicableDBSALT001356
Categories
UNII58H6RWO52I
CAS number1405-87-4
WeightAverage: 1422.693
Monoisotopic: 1421.748941023
Chemical FormulaC66H103N17O16S
InChI KeyInChIKey=CLKOFPXJLQSYAH-ABRJDSQDSA-N
InChI
InChI=1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35-,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48-,52-,53-,54-/m0/s1
IUPAC Name
(4R)-4-[(2S)-2-{[(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazol-4-yl]formamido}-4-methylpentanamido]-4-{[(1S,2S)-1-{[(3S,6R,9S,12R,15S,18R,21S)-18-(3-aminopropyl)-12-benzyl-15-[(2S)-butan-2-yl]-3-(carbamoylmethyl)-6-(carboxymethyl)-9-(1H-imidazol-4-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclopentacosan-21-yl]carbamoyl}-2-methylbutyl]carbamoyl}butanoic acid
SMILES
CC[[email protected]](C)[[email protected]](N)C1=N[C@@H](CS1)C(=O)N[C@@H](CC(C)C)C(=O)N[[email protected]](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[[email protected]]1CCCCNC(=O)[[email protected]](CC(N)=O)NC(=O)[C@@H](CC(O)=O)NC(=O)[[email protected]](CC2=CNC=N2)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC1=O)[C@@H](C)CC
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
KingdomOrganic compounds
Super ClassOrganic Polymers
ClassPolypeptides
Sub ClassNot Available
Direct ParentPolypeptides
Alternative Parents
Substituents
  • Polypeptide
  • Cyclic alpha peptide
  • N-acyl-alpha amino acid or derivatives
  • Macrolactam
  • Alpha-amino acid amide
  • N-substituted-alpha-amino acid
  • Thiazolecarboxamide
  • Imidazolyl carboxylic acid derivative
  • Fatty acyl
  • Benzenoid
  • N-acyl-amine
  • Fatty amide
  • Dicarboxylic acid or derivatives
  • Monocyclic benzene moiety
  • Heteroaromatic compound
  • Meta-thiazoline
  • Thiazole
  • Imidazole
  • Azole
  • Secondary carboxylic acid amide
  • Primary carboxylic acid amide
  • Lactam
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Thioether
  • Carboxylic acid
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections. Used against gram positive bacteria. Bacitracin is also used as an inhibitor of proteases and other enzymes. However, specific activity of bactracin's inhibition of protein disulfide isomerase has been called into question.
PharmacodynamicsBacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. As a polypeptide, toxic, and difficult to use chemical, bacitracin doesn't work well orally, however is very effective topically. Bacitracin exerts pronounced antibacterial action in vitro against a variety of gram-positive and a few gram-negative organisms. However, among systemic diseases, only staphylococcal infections qualify for consideration of bacitracin therapy.
Mechanism of actionBacitracin intereferes with the dephosphorylation of the 55-carbon, biphosphate lipid transport molecule C55-isoprenyl pyrophosphate (undecaprenyl pyrophosphate), which carries the building blocks of the peptidoglycan bacterial cell wall outside the inner membrane for construction. Bacitracin binds divalent transition metal ions (Mn(II), Co(II), Ni(II), Cu(II), and Zn(II)) which binds and oxidatively cleave DNA.
Related Articles
AbsorptionAbsorption of bacitracin following intramuscular injection is rapid and complete. Absorption from the gastrointestinal tract following oral administration is not appreciable. Absorption following topical application is negligible.
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationThe drug is excreted slowly by glomerular filtration.
Half lifeNot Available
ClearanceNot Available
ToxicityOral, mouse: LD50 = >3750 mg/kg.
Affected organisms
  • Enteric bacteria and other eubacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.7857
Blood Brain Barrier-0.9943
Caco-2 permeable-0.7639
P-glycoprotein substrateSubstrate0.7416
P-glycoprotein inhibitor INon-inhibitor0.898
P-glycoprotein inhibitor IINon-inhibitor0.9697
Renal organic cation transporterNon-inhibitor0.9073
CYP450 2C9 substrateNon-substrate0.7482
CYP450 2D6 substrateNon-substrate0.7884
CYP450 3A4 substrateNon-substrate0.5435
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.9011
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9122
Ames testNon AMES toxic0.7225
CarcinogenicityNon-carcinogens0.9045
BiodegradationNot ready biodegradable0.9799
Rat acute toxicity2.8201 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9936
hERG inhibition (predictor II)Non-inhibitor0.6586
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • X gen pharmaceuticals inc
  • App pharmaceuticals llc
  • Pfizer laboratories div pfizer inc
  • Pharmacia and upjohn co
  • Sagent pharmaceuticals inc
  • Altana inc
  • Eli lilly and co
  • Pharmaderm div altana inc
  • Pharmafair inc
  • Combe inc
  • Naska pharmacal co inc div rugby darby group cosmetics
  • Apothekernes laboratorium a/s
  • Paddock laboratories inc
Packagers
Dosage forms
FormRouteStrength
Kit
Ointmentophthalmic500 unit
Injection, powder, lyophilized, for solutionintramuscular50000 [USP'U]/1
Injectionintramuscular50000 [iU]/1
Injection, powder, for solutionintramuscular50000 [iU]/9.8mL
Injection, powder, for solutionintramuscular50000 [iU]/1
Injection, powder, for solutionintramuscular50000 [iU]/10mL
Ointmentophthalmic500 [USP'U]/g
Ointmentophthalmic500 [iU]/g
Ointmenttopical500 1/1
Powder for solutionintramuscular; topical50000 unit
Ointmenttopical500 [USP'U]/g
Ointmentophthalmic
Ointment; padtopical
Padtopical
Ointmenttopical
Ointmenttopical500 [iU]/g
Sticktopical
Creamtopical500 unit
Powdertopical
Ointmentophthalmic; topical
Creamtopical
Ointmenttopical500 U/g
Liquidtopical
Ointmenttopical400 [USP'U]/g
Ointmenttopical500 unit
Spraytopical500 [USP'U]/g
Creamtopical500 [USP'U]/g
Prices
Unit descriptionCostUnit
Bacitracin 5mm unit powder126.0USD each
Baciim strl 50000 unit vial19.8USD vial
Bacitracin 50000 unit vial13.31USD vial
Bacitracin 500 unit/gm ointmnt9.69USD g
CVS Pharmacy bacitracin 500 unit/gm oin0.15USD g
Sm first aid bacitracin ointmn0.1USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point221-225 °CNot Available
water solubilityFreely solubleNot Available
logP-0.8Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0245 mg/mLALOGPS
logP-2.9ALOGPS
logP-6.8ChemAxon
logS-4.8ALOGPS
pKa (Strongest Acidic)3.19ChemAxon
pKa (Strongest Basic)9.63ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count20ChemAxon
Hydrogen Donor Count17ChemAxon
Polar Surface Area530.87 Å2ChemAxon
Rotatable Bond Count31ChemAxon
Refractivity363.14 m3·mol-1ChemAxon
Polarizability147.15 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Brigt Oystese, “Zinc bacitracin composition for use as a feed supplement and method for making the same.” U.S. Patent US4096246, issued December, 1963.

US4096246
General References
  1. Tay WM, Epperson JD, da Silva GF, Ming LJ: 1H NMR, mechanism, and mononuclear oxidative activity of the antibiotic metallopeptide bacitracin: the role of D-Glu-4, interaction with pyrophosphate moiety, DNA binding and cleavage, and bioactivity. J Am Chem Soc. 2010 Apr 28;132(16):5652-61. doi: 10.1021/ja910504t. [PubMed:20359222 ]
  2. Karala AR, Ruddock LW: Bacitracin is not a specific inhibitor of protein disulfide isomerase. FEBS J. 2010 Jun;277(11):2454-62. doi: 10.1111/j.1742-4658.2010.07660.x. Epub 2010 Apr 30. [PubMed:20477872 ]
External Links
ATC CodesD06AX05J01XX10R02AB04
AHFS Codes
  • 08:12.28.08
  • 84:04.04
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (71.6 KB)
Interactions
Drug Interactions
Drug
ColistimethateColistimethate may increase the nephrotoxic activities of Bacitracin.
ColistinColistin may increase the nephrotoxic activities of Bacitracin.
KanamycinKanamycin may increase the nephrotoxic activities of Bacitracin.
NeomycinNeomycin may increase the nephrotoxic activities of Bacitracin.
Picosulfuric acidThe therapeutic efficacy of Sodium picosulfate can be decreased when used in combination with Bacitracin.
Polymyxin B SulfatePolymyxin B Sulfate may increase the nephrotoxic activities of Bacitracin.
StreptomycinStreptomycin may increase the nephrotoxic activities of Bacitracin.
Food InteractionsNot Available

Targets

Kind
Small molecule
Organism
Gram positive and gram negative bacteria
Pharmacological action
yes
Actions
antagonist
References
  1. Stone KJ, Strominger JL: Mechanism of action of bacitracin: complexation with metal ion and C 55 -isoprenyl pyrophosphate. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3223-7. [PubMed:4332017 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.(Microbial infection) The membrane-associated isoform acts as an entry...
Gene Name:
IDE
Uniprot ID:
P14735
Molecular Weight:
117967.49 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Medina V, Kesner L, Stracher A: Purification of nonantibiotic insulinase inhibitors from bacitracin. Biochem Med Metab Biol. 1993 Apr;49(2):255-64. [PubMed:8484964 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Tumor necrosis factor binding
Specific Function:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight...
Gene Name:
A2M
Uniprot ID:
P01023
Molecular Weight:
163289.945 Da
References
  1. Maxfield FR, Davies PJ, Klempner L, Willingham MC, Pastan I: Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits. Proc Natl Acad Sci U S A. 1979 Nov;76(11):5731-5. [PubMed:42903 ]
  2. Dickson RB, Willingham MC, Pastan I: Binding and internalization of 125I-alpha 2-macroglobulin by cultured fibroblasts. J Biol Chem. 1981 Apr 10;256(7):3454-9. [PubMed:6162847 ]
  3. Dickson RB, Willingham MC, Gallo M, Pastan I: Inhibition by bacitracin of high affinity binding of 125I-alpha 2M to plasma membranes. FEBS Lett. 1981 Apr 20;126(2):265-8. [PubMed:6165617 ]
  4. Hanover JA, Cheng S, Willingham MC, Pastan IH: alpha 2-Macroglobulin binding to cultured fibroblasts. Solubilization and partial purification of binding sites. J Biol Chem. 1983 Jan 10;258(1):370-7. [PubMed:6184373 ]
  5. Gliemann J, Larsen TR, Sottrup-Jensen L: Cell association and degradation of alpha 2-macroglobulin-trypsin complexes in hepatocytes and adipocytes. Biochim Biophys Acta. 1983 Mar 31;756(2):230-7. [PubMed:6187372 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23