Two distinct central serotonin receptors with different physiological functions.
Article Details
- CitationCopy to clipboard
Peroutka SJ, Lebovitz RM, Snyder SH
Two distinct central serotonin receptors with different physiological functions.
Science. 1981 May 15;212(4496):827-9.
- PubMed ID
- 7221567 [ View in PubMed]
- Abstract
Two distinct serotonin (5-hydroxytryptamine) receptors designated serotonin 1 and serotonin 2 bind tritium-labeled serotonin and tritium-labeled spiroperidol, respectively. Drug potencies at serotonin 2 sites, but not at serotonin 1 sites, predict their effects on the "serotonin behavioral syndrome," indicating that serotonin 2 sites mediate these behaviors. The limited correlation of drug effects with regulation by guanine nucleotides suggests that serotonin 1 sites might be linked to adenylate cyclase. Drug specificities of serotonin-elicited synaptic inhibition and excitation may reflect serotonin 1 and serotonin 2 receptor interactions, respectively.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Maprotiline 5-hydroxytryptamine receptor 2A Protein Humans UnknownBinderDetails Maprotiline 5-hydroxytryptamine receptor 2C Protein Humans UnknownBinderDetails Serotonin 5-hydroxytryptamine receptor 2A Protein Humans UnknownNot Available Details