Inhibition of neuronal and extraneuronal uptake of noradrenaline by ketamine in the isolated perfused rat heart.

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Salt PJ, Barnes PK, Beswick FJ

Inhibition of neuronal and extraneuronal uptake of noradrenaline by ketamine in the isolated perfused rat heart.

Br J Anaesth. 1979 Sep;51(9):835-8.

PubMed ID
508488 [ View in PubMed
]
Abstract

The effect of ketamine on the uptake of 3H-noradrenaline in the isolated perfused rat heart was studied. A dose-dependent inhibition of uptake by both neuronal and extraneuronal processes was found. These effects may account for the positive chronotropic and pressor effects of the drug.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
KetamineSodium-dependent noradrenaline transporterProteinHumans
Unknown
Inhibitor
Details