Update on the therapy of Behcet disease.

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Saleh Z, Arayssi T

Update on the therapy of Behcet disease.

Ther Adv Chronic Dis. 2014 May;5(3):112-34. doi: 10.1177/2040622314523062.

PubMed ID
24790727 [ View in PubMed
]
Abstract

Behcet disease is a chronic inflammatory systemic disorder, characterized by a relapsing and remitting course. It manifests with oral and genital ulcerations, skin lesions, uveitis, and vascular, central nervous system and gastrointestinal involvement. The main histopathological finding is a widespread vasculitis of the arteries and veins of any size. The cause of this disease is presumed to be multifactorial involving infectious triggers, genetic predisposition, and dysregulation of the immune system. As the clinical expression of Behcet disease is heterogeneous, pharmacological therapy is variable and depends largely on the severity of the disease and organ involvement. Treatment of Behcet disease continues to be based largely on anecdotal case reports, case series, and a few randomized clinical trials.

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